Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.
J Cell Biol
; 143(2): 547-60, 1998 Oct 19.
Article
em En
| MEDLINE
| ID: mdl-9786962
ABSTRACT
In many malignant cells, both the anchorage requirement for survival and the function of the p53 tumor suppressor gene are subverted. These effects are consistent with the hypothesis that survival signals from extracellular matrix (ECM) suppress a p53-regulated cell death pathway. We report that survival signals from fibronectin are transduced by the focal adhesion kinase (FAK). If FAK or the correct ECM is absent, cells enter apoptosis through a p53-dependent pathway activated by protein kinase C lambda/iota and cytosolic phospholipase A2. This pathway is suppressible by dominant-negative p53 and Bcl2 but not CrmA. Upon inactivation of p53, cells survive even if they lack matrix signals or FAK. This is the first report that p53 monitors survival signals from ECM/FAK in anchorage- dependent cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Transdução de Sinais
/
Moléculas de Adesão Celular
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Proteína Supressora de Tumor p53
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Apoptose
/
Matriz Extracelular
Limite:
Animals
Idioma:
En
Revista:
J Cell Biol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos