Schizophrenia and the serotonin transporter gene.
Psychiatr Genet
; 8(4): 207-12, 1998.
Article
em En
| MEDLINE
| ID: mdl-9861638
ABSTRACT
A case control study was conducted among cases with schizophrenia (DSM IV criteria) and screened adult controls from three cohorts. Bi-allelic polymorphisms in the promoter region of the serotonin transporter gene (5-HTT) were examined in conjunction with those of the serotonin 5-HT2a receptor (HTR2). No significant association with 5-HTT was detected among US Caucasians (n = 207), African-Americans (n = 84) or Caucasians from Sweden (n = 221). However, survival analysis suggested an association with the age at onset among the Swedish cases. The association should be considered tentative as it was not evident in the smaller US samples. The following exploratory analyses among the US samples were also not significant associations with subgroups of patients based on familiality or response to medications, or altered risk due to the joint effects of 5-HTT and HTR2 genotypes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Esquizofrenia
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Middle aged
País/Região como assunto:
America do norte
/
Europa
Idioma:
En
Revista:
Psychiatr Genet
Assunto da revista:
GENETICA
/
PSIQUIATRIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos