Simultaneous HPLC determination of multiple components in a commercial cosmetic cream.
J Pharm Biomed Anal
; 18(1-2): 213-7, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9863960
ABSTRACT
A high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate (I), imidazolidinylurea (II), a mixture of methyl-(III), ethyl-(IV), propyl-(V), butyl-(VI) parabens dissolved in phenoxyethanol, and ascorbyl palmitate (VII), was studied by using a cyano-propyl column and a methanol gradient at 220 and 240 nm. Calibration curves were found to be linear in the 0.05-5 mg ml(-1) range (compounds I, II, VII) and 0.9-160 mg ml(-1) (compounds III-VI). Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. An extraction method is developed and validated in order to apply this chromatographic method to a commercial cosmetic cream. The precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (1.57-2.21%) was excellent for all compounds I-VII.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pomadas
/
Técnicas de Química Analítica
/
Cosméticos
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Itália