DAP-2, the Drosophila homolog of transcription factor AP-2.
Mech Dev
; 76(1-2): 191-5, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9867351
ABSTRACT
Transcription factor AP-2 is essential for craniofacial, nervous system, and limb development in the mouse. We report here the cloning and expression pattern analysis of DAP-2, the Drosophila homolog of AP-2 family genes. DAP-2 is expressed in discrete regions of procephalic neuroectoderm, the brain, ventral nerve cord, and maxillary segment during Drosophila embryogenesis, and in the brain, optic lobes, ventral nerve cord, antenno-maxillary complex, and antennal and leg imaginal disks in third instar larvae. Protein sequence conservation and parallels between the embryonic expression patterns of DAP-2 and mammal ian AP-2 family genes indicate that transcription factor AP-2 has been structurally and functionally conserved during metazoan evolution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Regulação da Expressão Gênica no Desenvolvimento
/
Proteínas de Insetos
/
Proteínas de Drosophila
/
Proteínas de Ligação a DNA
/
Drosophila melanogaster
Limite:
Animals
Idioma:
En
Revista:
Mech Dev
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Suíça