Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.
Bioorg Med Chem Lett
; 8(19): 2719-24, 1998 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-9873610
ABSTRACT
Replacement of the C-terminal carboxylic acid functionality of peptide inhibitors of hepatitis C virus (HCV) NS3 protease (complexed with NS4A peptide cofactor) by activated carbonyl groups does not produce any substantial increase in potency. These latter inhibitors also inhibit a variety of other serine and cysteine proteases whereas the carboxylic acids are specific. Norvaline was identified as a chemically stable replacement for the P1 residue of Ac-DDIVPC-OH which was also compatible with activated carbonyl functionalities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Inibidores de Serina Proteinase
/
Proteínas não Estruturais Virais
/
Hepacivirus
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Canadá