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1.
J Am Anim Hosp Assoc ; 60(1): 36-39, 2024 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-38175977

RESUMO

A 3 yr old spayed female Cavalier King Charles spaniel was referred for insidious ataxia and paraparesis. A thoracolumbar lesion was suspected. Computed tomography showed focal osteolysis of the vertebral body and pedicles of T5. In addition, a hyperdense, extradural material within the vertebral canal, causing spinal cord compression on the right side, was present. The lesion was confirmed with magnetic resonance imaging. A T4-T5 hemi-dorsal laminectomy was performed to decompress the spinal cord. Histopathological examination was consistent with vertebral angiomatosis. After the surgery, the dog rapidly improved; however, 5 mo later the clinical signs relapsed. Vertebral angiomatosis is a vasoproliferative disorder, rarely reported as a cause of myelopathy in cats. This condition has not previously been reported in dogs. This case report describes the clinical features, the diagnostic findings, and the follow-up of a young dog with vertebral angiomatosis.


Assuntos
Angiomatose , Doenças do Cão , Compressão da Medula Espinal , Doenças da Medula Espinal , Animais , Cães , Feminino , Angiomatose/diagnóstico , Angiomatose/cirurgia , Angiomatose/veterinária , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Compressão da Medula Espinal/diagnóstico por imagem , Compressão da Medula Espinal/etiologia , Compressão da Medula Espinal/cirurgia , Compressão da Medula Espinal/veterinária , Doenças da Medula Espinal/veterinária , Tomografia Computadorizada por Raios X
3.
Neuroradiology ; 65(12): 1825-1834, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37794141

RESUMO

PURPOSE: Sturge-Weber syndrome (SWS) is a developmental disorder with venous hypertension and associated tissue responses including pial angiomatosis, cortical calcifications, and cerebral atrophy. Arterial spin-labeled (ASL) perfusion is an advanced MR sequence which can assess perfusion, without the need for contrast. We systematically evaluated the potential benefits of using ASL in Sturge-Weber syndrome, to determine the extent of intracranial perfusion abnormality and stage of disease, relevant for prognostication and surgical planning. METHODS: Two pediatric neuroradiologists retrospectively evaluated ASL perfusion imaging of 31 children with confirmed SWS and recorded the presence of hyper-perfusion, hypo-perfusion, or normal perfusion. The presence and distribution of ASL abnormality were compared against the presence and side of atrophy/calcification and pial angiomatosis on standard MR sequences. RESULTS: Thirty-one children (52% female, median age 16.7 months) with SWS had ASL imaging. Seven (23%) had hyper-perfusion, 15 (48%) had hypo-perfusion, and 9 (29%) had no perfusion abnormalities. ASL perfusion abnormality matched the location of SWS findings on conventional imaging in 86% (19/22). ASL demonstrated statistically significant increased perfusion in the early stage of the disease and decreased perfusion when there was atrophy. The parietal lobe was involved in 86% of cases. CONCLUSION: ASL perfusion imaging is an advanced technique which may contribute to earlier diagnosis and more accurate prognostication of Sturge-Weber syndrome, helping guide management and potential surgical planning.


Assuntos
Angiomatose , Síndrome de Sturge-Weber , Criança , Humanos , Feminino , Lactente , Masculino , Síndrome de Sturge-Weber/diagnóstico por imagem , Estudos Retrospectivos , Estudos Transversais , Imageamento por Ressonância Magnética/métodos , Perfusão , Atrofia
7.
Breast Dis ; 42(1): 147-153, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37154175

RESUMO

Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast pathology, which most commonly presents incidentally along with other breast pathologies. The etiology and pathogenesis of PASH are still unknown; however, there is some evidence suggesting PASH is hormone dependent. The clinical history, presentation, and imaging appearance of PASH are variable. Clinically, PASH has a wide spectrum of presentations, from being silent to gigantomastia. On imaging, PASH demonstrates various benign to suspicious features. Here we summarize PASH's clinical presentation, histopathology, imaging features, and management.


Assuntos
Angiomatose , Doenças Mamárias , Neoplasias da Mama , Humanos , Feminino , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Mama/diagnóstico por imagem , Mama/patologia , Doenças Mamárias/diagnóstico por imagem , Doenças Mamárias/patologia , Hiperplasia/patologia , Angiomatose/diagnóstico por imagem , Angiomatose/patologia
8.
Breast Dis ; 42(1): 115-119, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37066901

RESUMO

BACKGROUND: Pseudoangiomatous stromal hyperplasia is a rare benign breast stromal proliferative lesion of the breast. Clinical presentation ranges from rapidly growing mass to incidental identification in routine screening. This difference in manifestation and its rarity makes it difficult to be a standard treatment protocol. Therefore, we aimed to share our clinical experience in Pseudoangiomatous stromal hyperplasia. METHODS: The files of patients who underwent core biopsy or surgical excision due to a breast mass and resulted in pseudoangiomatous stromal hyperplasia between January 2013 and December 2021 were included in the study. RESULTS: 17 patients with a median age of 37 (22-68) were found Pseudoangiomatous stromal hyperplasia confirmed by surgical excision or core biopsy. Chosen treatment option was observation in 8 patients (47.1%), while surgical excision was used in 9 (52.9%) patients. The mean follow-up period was 55.24 ± 26.72 (13-102) months. None of the patients observed the Malignant transformation during the follow-up period. CONCLUSION: For Pseudoangiomatous Stromal Hyperplasia of the breast, surgical excision with clean margins or close follow-up after diagnosis confirmation by tissue biopsy is sufficient. Pseudoangiomatous Stromal Hyperplasia is not a risk factor for developing breast cancer.


Assuntos
Angiomatose , Doenças Mamárias , Neoplasias da Mama , Humanos , Feminino , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Neoplasias da Mama/patologia , Doenças Mamárias/diagnóstico , Doenças Mamárias/cirurgia , Doenças Mamárias/patologia , Mama/cirurgia , Mama/patologia , Hiperplasia/patologia , Angiomatose/diagnóstico , Angiomatose/cirurgia , Angiomatose/patologia
9.
Int J Surg Pathol ; 31(8): 1437-1448, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37032453

RESUMO

Vascular lesions of the breast are uncommon, however, these are increasingly encountered now due to more frequent use of magnetic resonance imaging. They comprise a spectrum of lesions including benign, atypical, and malignant tumors. The prototype is a hemangioma, which is most often nonpalpable and is detected on routine screening. Different histopathologic subtypes of hemangioma have been described, including perilobular, venous, cavernous, and capillary hemangioma. Other benign vascular lesions include anastomosing hemangioma, a well-circumscribed proliferation of anastomosing blood vessels with lobular or diffuse growth pattern which affects a large segment of the breast, presenting as a painless slow enlarging palpable mass. Recent data suggest that benign vascular lesions diagnosed on core needle biopsy with concordant radiologic and pathologic findings do not require excision and have an excellent prognosis, except angiomatosis, which can be locally aggressive and may recur. The main focus of this study is to present the radiographic, gross, and histopathologic characteristics of benign vascular lesions of the breast and their differential diagnoses.


Assuntos
Angiomatose , Neoplasias da Mama , Hemangioma , Humanos , Feminino , Recidiva Local de Neoplasia/patologia , Mama/diagnóstico por imagem , Mama/patologia , Hemangioma/diagnóstico por imagem , Hemangioma/patologia , Biópsia com Agulha de Grande Calibre , Angiomatose/diagnóstico por imagem , Angiomatose/patologia , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia
10.
J Fish Dis ; 46(7): 723-730, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36916637

RESUMO

The skin represents an indicator of an animal's health status. Causes of cutaneous diseases in fish most often trace back to biological agents. However, fish skin diseases can also arise from a complex interaction of infectious and non-infectious causes, making it more difficult to identify a specific aetiology. In the period between April and September of the years 2019-2022, four koi carp (Cyprinus carpio koi) from two European countries presented with multifocal, irregularly round, few mm to 1 cm, variably raised cutaneous reddened areas. The fish displayed good general condition. Cutaneous samples, investigated by microbiological and molecular methods and microscopy, did not indicate a primary pathogenic agent. Gross and histological findings of the cutaneous biopsies were consistent with a multifocal/reactive process centred on dermal vessels. The histological features were reminiscent of angiomatosis, a benign proliferative condition affecting the dermal vessels of mammals, including human patients. The clinical-pathological presentation and the dermatologic condition that affected the koi carp are discussed and compared with the veterinary and human literature.


Assuntos
Angiomatose , Carpas , Doenças dos Peixes , Humanos , Animais , Pele , Europa (Continente) , Mamíferos
11.
Fetal Pediatr Pathol ; 42(4): 545-556, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36734681

RESUMO

Objective: To investigate the clinicopathological features of children with Sturge-Weber syndrome and to analyze the correlation between the distribution area of leptomeningeal angiomatosis, the degree of cerebral cortical calcification, and the degree of cerebral atrophy associated with epileptic seizures. Methods: 10 children were diagnosed with SWS with FCD IIIc by histopathology and immunohistochemistry. Spearman correlation analysis was used to calculate the association of SWS with FCD IIIc and seizures in children. Results: The leptomeningeal angiomatosis area was markedly positively correlated with the degree of brain atrophy in 10 children with SWS (r = 0.783, p = 0.007). The distribution of leptomeningeal hemangiomatosis, the degree of cortical calcification, and brain atrophy were not significantly correlated with epilepsy. Conclusion: SWS may be accompanied by FCD IIIc. The more extensive the cerebral lobes of leptomeningeal angiomatosis in SWS, the more pronounced the brain atrophy.


Assuntos
Angiomatose , Epilepsia , Displasia Cortical Focal , Síndrome de Sturge-Weber , Criança , Humanos , Síndrome de Sturge-Weber/complicações , Síndrome de Sturge-Weber/diagnóstico , Síndrome de Sturge-Weber/patologia , Convulsões/etiologia , Angiomatose/complicações , Angiomatose/diagnóstico , Atrofia/complicações
14.
Br J Neurosurg ; 37(5): 1215-1219, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33084435

RESUMO

BACKGROUND: Diffuse cerebral angiomatosis (DCA) is a diffuse infiltration of normal brain by complex vascular structures. It differs from arteriovenous malformations (AVMs) that are composed of a nidus of vessels through which arteriovenous shunting occurs without interposed functional brain parenchyma. A rare subgroup of AVMs is diffuse with no recognizable nidus with functional neuronal tissue interspersed within the malformed vessels. We present a rare association of DCA and cerebral arterial aneurysm, which dramatically influenced the patient's prognosis. CASE DESCRIPTION: A 43-year-old male patient with right hemispheric diffuse cerebral angiomatosis presented with a ruptured basilar tip aneurysm that was successfully embolised. Unfortunately, the patient developed a locked-in syndrome. CONCLUSION: The present report shows a possible association between diffuse cerebral angiomatosis and cerebral aneurysms, but this association appears to be less strong than it is with other AVMs.


Assuntos
Aneurisma Roto , Angiomatose , Aneurisma Intracraniano , Malformações Arteriovenosas Intracranianas , Masculino , Humanos , Adulto , Malformações Arteriovenosas Intracranianas/complicações , Malformações Arteriovenosas Intracranianas/diagnóstico por imagem , Malformações Arteriovenosas Intracranianas/cirurgia , Angiografia Cerebral , Aneurisma Intracraniano/complicações , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia , Prognóstico , Angiomatose/complicações , Angiomatose/diagnóstico por imagem , Angiomatose/cirurgia , Aneurisma Roto/complicações
17.
Pol Przegl Chir ; 96(0): 78-83, 2023 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-38348993

RESUMO

<b><br>Aim:</b> The study was conducted to systematically analyze the recent peer-reviewed literature related to tumoral pseudoangiomatous stromal hyperplasia (PASH) in males.</br> <b><br>Materials and methods:</b> Articles published in peer-reviewed journals of repute from 2012 to 2023 were evaluated for eight variables: 1) the age of the patient, 2) clinical presentation, 3) laterality (unilateral or bilateral), 4) associated breast disorder, 5) the presence of systemic co-morbidity, 6) imaging modalities aiding diagnosis, 7) treatment, and 8) recurrence.</br> <b><br>Results:</b> There were 10 patients ranging in age from 1 year to 67 years (mean: 34.5 years). In 8 cases (80%), there were breast lumps; in 2 cases (20%), there were axillary lumps at presentation. Pain was not a prominent symptom. Six patients (60%) had another breast disorder at presentation and 3 (30%) had significant systemic co-morbidities, including diabetes and renal insufficiency. The greatest dimension of the lumps ranged from 2 cm to 12 cm, with 80% of the lumps being below 5 cm in size. Imaging modalities utilized in evaluation included breast ultrasound (USG), mammograms, computerized tomography (CT), and magnetic resonance imaging (MRI). All the cases were treated surgically, and the final diagnosis was made only after the analysis of the surgical specimen. Recurrence was recorded in 2 (20%) cases.</br> <b><br>Conclusions:</b> Tumoral PASH is a benign myofibroblastic proliferation disorder rarely reported in males. This condition should be considered a differential diagnosis of breast or axillary lumps, and an evaluation should be initiated accordingly. The recommended course of treatment is adequate surgical excision with regular clinical and radiological follow-up.</br>.


Assuntos
Angiomatose , Doenças Mamárias , Neoplasias , Humanos , Masculino , Lactente , Doenças Mamárias/diagnóstico por imagem , Doenças Mamárias/cirurgia , Mama/diagnóstico por imagem , Mama/cirurgia , Mama/patologia , Hiperplasia/patologia , Angiomatose/diagnóstico , Angiomatose/cirurgia , Angiomatose/patologia
18.
J Cancer Res Ther ; 19(7): 1714-1720, 2023 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-38376269

RESUMO

ABSTRACT: Pseudoangiomatous stromal hyperplasia (PASH) is a benign entity of the breast and typically found incidentally or as a palpable mass. It usually affects women in the reproductive age group. In men, it is associated with gynecomastia. While the exact etiology is unknown, PASH is considered hormonally responsive. The mammography and ultrasonography findings are nonspecific. Grossly, PASH is a well-circumscribed, firm, rubbery mass with solid, homogenous, gray-white cut surface. On histologic examination, it is characterized by the presence of open slit-like spaces in dense collagenous stroma. The spindle cells express progesterone receptors and are positive for vimentin, actin, and CD34. PASH lesions should be surgically excised if increasing in size or associated with symptoms, also in cases of suspicious imaging findings or other lesions are synchronously diagnosed that require excision. In other small incidentally detected asymptomatic cases observation with clinicoradiological follow-up can be considered. It is associated with a good prognosis with no increased risk to develop breast cancer. Hence, the operating surgeon and pathologist should be aware of this not so uncommon entity so that patients are not subjected to unnecessary excision and subsequent physical and mental morbidity associated with it. In this article, we present a case report and also provide a brief review of the sparse literature on PASH, discussing clinical presentation, etiology and pathogenesis, radiopathological features, differential diagnosis, and the implications for further patient management and prognosis.


Assuntos
Angiomatose , Doenças Mamárias , Neoplasias da Mama , Hiperplasia , Masculino , Humanos , Feminino , Doenças Mamárias/diagnóstico , Doenças Mamárias/cirurgia , Neoplasias da Mama/diagnóstico , Mama , Mamografia
19.
Surg Clin North Am ; 102(6): 989-1005, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36335933

RESUMO

Gynecomastia is a common benign breast disease involving abnormally increased mammary gland tissue that can affect men of all ages. It is usually due to a hormonal imbalance without a definitive underlying cause (idiopathic), or secondary to medications/drugs, systemic disorders, or malignancy. Gynecomastia is often self-limiting, and its management is watchful waiting. Other male benign breast diseases, such as cysts, lipomas, seromas, infections, and pseudoangiomatous stromal hyperplasia, should be worked up in a similar manner and often require surgical drainage or excision.


Assuntos
Angiomatose , Doenças Mamárias , Ginecomastia , Lipoma , Masculino , Humanos , Ginecomastia/diagnóstico , Ginecomastia/etiologia , Ginecomastia/cirurgia , Angiomatose/complicações , Angiomatose/patologia , Angiomatose/cirurgia , Doenças Mamárias/diagnóstico , Doenças Mamárias/etiologia , Doenças Mamárias/terapia , Hiperplasia/complicações
20.
Am Surg ; 88(8): 1919-1921, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35435015

RESUMO

Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon, benign breast lesion often diagnosed incidentally and frequently mistaken for fibroadenoma given similar radiographic appearance. Histopathology classically reveals diffuse, dense fibrous stromal background with a complex network of spindle cells forming slit-like spaces, giving it the appearance of angiomatous proliferation. Surgical excision is generally not necessary. Here we present two unusual cases of PASH: an adolescent patient with bilateral rapid onset of symptoms, and a premenopausal patient with bilateral, diffuse, recurrent PASH. Both required mastectomy. We aim to highlight the variable nature of presentation and briefly review current management options.


Assuntos
Angiomatose , Neoplasias da Mama , Adolescente , Angiomatose/diagnóstico por imagem , Angiomatose/cirurgia , Mama/diagnóstico por imagem , Mama/patologia , Mama/cirurgia , Doenças Mamárias , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Feminino , Humanos , Hiperplasia/patologia , Hiperplasia/cirurgia , Mastectomia
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