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1.
Int J Paleopathol ; 44: 90-104, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38181478

RESUMO

OBJECTIVE: This paper reviews factors confounding the understanding of the past occurrence of anemia. Using the evidence gathered, a framework is presented of ways forward to enable greater confidence in diagnosing acquired anemia in paleopathology, facilitating insights into longer-term perspectives on this globally relevant condition. RESULTS: To date, porotic lesions have been central to paleopathological investigations of anemia. The fact that porotic bone lesions are omnipresent and have multiple causes but are likely to have a relatively low, age-related frequency in individuals with anemia, a condition that will have been common in past communities, is confounding. METHODS: Establishing frameworks that move away from porotic lesions is proposed to facilitate higher levels of more accurate anemia diagnoses in paleopathology. SIGNIFICANCE: Acceptance of the fundamental principle that anemia may be better considered as a condition requiring metric evaluation of bone structures, supplemented by careful consideration of lesions, will advance understanding of acquired anemia in past communities. Such an approach would provide a clear basis for further consideration of congenital conditions causing anemia, such as sickle-cell disease and thalassemia. LIMITATIONS: This paper simply opens the conversation on the better diagnosis of anemia in paleopathology; it starts the iterative process of achieving some consensus and progress on diagnosing anemia in paleopathology. SUGGESTIONS FOR FURTHER RESEARCH: Engagement with ideas presented, sharing data and development of metric parameters will assist in identifying the effects of marrow hyperplasia on bone, enabling more robust work on the important topic of anemia.


Assuntos
Doenças Ósseas , Talassemia , Humanos , Paleopatologia , Comunicação , Consenso
2.
Anthropol Anz ; 81(1): 69-78, 2024 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-37539649

RESUMO

Porotic hyperostosis and cribra orbitalia are pathological changes occurring on the human skull. These changes were observed and evaluated on skeletal remains from Detkovice - Za zahradama and Vídenská Street in Brno; both sites are dated back to the 10th to 12th centuries AD. A total of 605 subjects were assessed for age, sex, and the above-stated pathologies using standard methods. The influence of age and sex on the occurrence of these pathologies was examined statistically. Results indicated that at the site of Detkovice - Za zahradama, porotic hyperostosis, and cribra orbitalia do not depend on sex or age. However, at Vídenská Street in Brno, these pathologies do not depend on sex, but they depend on age so a higher incidence of pathologies in juveniles is observed. Differences between both sites could be caused by different numbers of evaluated individuals or different state of preservation of skeletal remains. The aetiology of the origin of these pathologies could not be determined by the methodology used here, but with the prevailing lower age of pathological subjects, a lack of nutrition with consequent absence of iron and developing anaemia might be the cause. Based on our statistical data, we can observe that the pathologies we studied occur more frequently in children older than newborns and younger infants. This may indicate that these studied pathologies arise only during the lifetime of the individual and do not have a prenatal occurrence.


Assuntos
Restos Mortais , Hiperostose , Lactente , Criança , Humanos , Recém-Nascido , Restos Mortais/patologia , República Tcheca , Crânio/patologia , Hiperostose/epidemiologia , Hiperostose/etiologia , Hiperostose/patologia , Cabeça , Paleopatologia/métodos
3.
Tuberculosis (Edinb) ; 143S: 102348, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38012915

RESUMO

Molecular phylogeny work has shown that tuberculosis is ancient human-adapted infection predating the Neolithic period. They also show that the Upper Paleolithic is a key period of emergence of the MTB complex strains, contemporary with the exit of modern man from Africa. Despite the richness of Upper Paleolithic sites in Eurasia and the relative abundance of human remains, the only proven case of Paleolithic tuberculosis has been described so far date from the Azilian, a culture of the European Final Paleolithic, which is more recent than the ancient Neolithic sites of the Near East, area that currently hold the record for the oldest paleopathological evidence of tuberculosis. The purpose of this review is to present evidence for the existence of tuberculosis in the Paleolithic and to list hypotheses explaining the weak demonstrative contribution of paleopathology for pre-Neolithic periods.


Assuntos
Mycobacterium tuberculosis , Tuberculose , Masculino , Humanos , Paleopatologia , África
4.
Tuberculosis (Edinb) ; 143S: 102365, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38012917

RESUMO

Two anthropological collections of the 8-9th century AD from the forest-steppe area of the southern Eastern Europe has been the subject of analysis of the osteo-articular alterations concerning tuberculosis related lesions. According to archaeological data, the Mayaki and Dmitrievka groups are from the territory of Khazar Khaganate, which is well-known by historical data. It was a traditional population with settled pastoral farming. There were studied 292 adult human remains by macroscopic morphological and radiological methods. The completeness of the skeletons could have been better due to the intentional selection of their parts for the museum funds, so there were limitations for the differential diagnosis of TB by morphological criteria. In general, 31 individuals (20 men, 11 women) were marked as possible candidates with skeletal TB. The number of skeletons with possible specific infections from the two series is comparable, but according to sex distribution, there are some significant differences. If in the Dmitrievka group, there was approximately the same distribution of the number of cases of possible infected men and women; in the Mayaki group then there was a significant difference in the prevalence of the male sample. Various reasons can explain the observed differences. Firstly, we cannot rule out an error in the diagnosis of tuberculosis only by morphological methods since the preservation of the skeletons leaves much to be desired. Secondly, as it is known, only a few percent of tuberculosis patients show skeletal alterations, so the direct quantitative comparison cannot be adequate in paleopathological studies. The ambiguity of morphological criteria, particularly for destructive lesions of bone other than vertebrae, does not allow asserting that all identified cases result from TB. However, the results of differential diagnosis can underline that at least half of the skeletons have skeletal alterations most likely related to TB. The final analysis of the remains by aDNA methods will permit more certain confirmation of the diagnosis.


Assuntos
Mycobacterium tuberculosis , Tuberculose , Adulto , Humanos , Masculino , Feminino , Mycobacterium tuberculosis/genética , Tuberculose/diagnóstico , Tuberculose/epidemiologia , Tuberculose/história , Osso e Ossos , Europa Oriental/epidemiologia , Diagnóstico Diferencial , Paleopatologia/métodos
5.
Tuberculosis (Edinb) ; 143S: 102410, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38012916

RESUMO

Investigations of non-adult remains are particularly suitable for finding epidemic periods in past populations. This study presents a probable unique example of osseous manifestation of tuberculosis on a child's skeletal remains from medieval Hungary. Between 2009 and 2011 the Field Service for Cultural Heritage excavated the exceptional cemetery of Perkáta - Nyúli-dulo in Hungary, with around 5000+ graves. The analysed skeleton (SNR 948) was located in the medieval (10-16th century) part of the cemetery. Besides the standard macroscopic pathological observation, we also performed radiographic analysis. The remains of the child (13-14 year-old) showed numerous skeletal lesions: the ribs have proliferative lesions (dense nodules) on the visceral surface of the shaft, lytic lesions with rounded edges occurred on the thoracic and lumbar vertebral bodies, and on the facies auricularis of the left ilium we can see pitting and new bone formation. What makes this pathological case exceptional is the significant change in the manubrium. It shows extensive osteolytic lesions, probably due to tuberculous osteomyelitis, which is a unique phenomenon in an archaeological context. This rare type of extra-spinal tuberculous osteomyelitis appears in less than 1% of cases with skeletal TB, and even less in case of children, according to modern medical literature. Although some cases of slight lesions on the manubrium have been described from an archaeological context, no such cases showing advanced lesions have been published so far. In the future, biomolecular analyses should be conducted as well, in order to confirm the presence of TB in this individual.


Assuntos
Mycobacterium tuberculosis , Osteomielite , Tuberculose Osteoarticular , Criança , Humanos , Adolescente , Hungria , Cemitérios/história , Tuberculose Osteoarticular/diagnóstico por imagem , Tuberculose Osteoarticular/história , Osteomielite/diagnóstico por imagem , Paleopatologia/história
6.
Tuberculosis (Edinb) ; 143S: 102387, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38012922

RESUMO

The causative agent of tuberculosis is still a widespread pathogen, which caused the death of ca. 1.6 million people globally in 2021. The paleopathological study of human remains revealed the antiquity of the disease and its continuous presence throughout the history of humankind. The Carpathian Basin has always been a biocultural melting pot, since it has seen several migrations over the centuries, and served as a location of admixture and interaction for numerous populations of different cultures. Thus, this geographical territory is ideal for the examination of the coevolutionary processes of hosts and their pathogens. We aimed to reveal the spatial and temporal distribution of tuberculosis cases excavated inside the borders of Hungary between the 2nd and 16th centuries CE. We established a comprehensive database by collecting 114 already published cases and introducing 39 new cases. The involved cases include those that have been confirmed by different molecular methods, as well as possible infections that were identified based on the presence of macromorphological and radiological alterations. The progress of future molecular and paleopathological studies can be facilitated by our dataset, as it presents spatial and temporal information concerning the spread of the disease in the Carpathian Basin, as well as the biological profile and detailed paleopathological description of lesions illustrated by photo- and radiographs.


Assuntos
Mycobacterium tuberculosis , Tuberculose Osteoarticular , Humanos , Mycobacterium tuberculosis/genética , DNA Bacteriano , Tuberculose Osteoarticular/história , Hungria , Paleopatologia/métodos
7.
Tuberculosis (Edinb) ; 143S: 102419, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38012926

RESUMO

In 1932, skeletal remains of two Neanderthal individuals, a young adult female and a 3-4-year-old child, were discovered in Subalyuk Cave in Northern Hungary [1,2]. Results of the anthropological examination were published some years after this important discovery. Methodological progress encouraged re-examination of the material during the last few years. Radiocarbon dating revealed a chronological age of 39,732-39,076 cal. BP for the adult female and 36,117-35,387 cal. BP for the child [3]. Morphological paleopathological studies of these Neanderthal remains uncovered distinct evidence of skeletal infections. Alterations of the adult individual's sacrum suggest probable early-stage sacroiliitis, while several vertebral bodies indicate superficial osseous remodelling of infectious origin. Traces of pathological lesions were observed on the endocranial surface of the child's skull, reflecting a reaction of meningeal tissues, a consequence of a probable TB-related meningeal infectious process. Results of recent paleomicrobiological examinations - lipid biomarker and aDNA studies - support the morphological diagnosis of probable TB infections [4].


Assuntos
Mycobacterium tuberculosis , Homem de Neandertal , Tuberculose , Adulto Jovem , Humanos , Feminino , Pré-Escolar , Animais , Hungria , Osso e Ossos , Paleopatologia/métodos
9.
Tuberculosis (Edinb) ; 143S: 102396, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38012936

RESUMO

Tuberculosis (TB) has long been a major scourge of humankind. Paleopathological and paleomicrobiological studies have revealed the past presence of the disease on a large spatial and temporal scale. The antiquity of the disease has extensively been studied in the Carpathian Basin, given its dynamic population and cultural changes since prehistory. These studies, however, have mainly focused on the populations living during the Common Era. The aim of this paper is to present the published and the recently discovered cases of prehistoric TB, from the Neolithic (6000-4500/4400 BCE) to the Bronze Age (2600/2500-800 BCE) Central Carpathian Basin (Hungary). We summarize 18 published cases and present new cases dating to the Neolithic period and introduce 3 newly discovered Bronze Age cases of TB. Despite extensive research, TB has not yet been identified from the Copper and Iron Ages in the Carpathian Basin. Considering the state of TB research, and supplemented by our prehistoric dataset, the spatio-temporal pattern of the disease can be further elucidated, thus advancing future molecular and paleopathological studies. Our dataset offers comprehensive spatial and temporal information on the spread of the disease in the Carpathian Basin, along with a detailed biological profile of the demonstrated cases and extensive paleopathological descriptions of the observed lesions, complemented by photographic evidence. This invaluable resource paves the way for enhanced understanding and progress in the field.


Assuntos
Mycobacterium tuberculosis , Tuberculose Osteoarticular , Humanos , Hungria , Europa (Continente)/epidemiologia , Tuberculose Osteoarticular/microbiologia , Paleopatologia
10.
Int J Paleopathol ; 43: 106-111, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37918134

RESUMO

OBJECTIVE: The promontory of the middle ear was recently suggested to be an appropriate site for diagnosing otitis media (OM) in archaeological bones by endoscopic inspection. The present study scrutinized the underlying assumption that a bulgy, irregular promontorial surface represents a pathological condition. MATERIALS: We compared an allegedly healthy individual and an allegedly diseased individual in skeletal remains of two human individuals from the early Medieval period in Germany. METHODS: The specimens were studied using microscopic analyses of thin ground sections. RESULTS: The osseous architecture of the three-layered promontorial wall was the same in both specimens. Both the contour of the resorption front of the middle layer and the thickness of the overlying outer periosteal layer showed some variation, resulting in an either smooth or a bulgy promontorial surface, while signs of resorptive or proliferative changes at the periosteal surface were missing in both cases. CONCLUSIONS: Our results suggest that an irregular promontorial surface represents normal variation in the development of the otic capsule rather than a pathological condition. We therefore conclude that the promontory is not an appropriate site for diagnosing OM in archaeological bone. SIGNIFICANCE: The study contributes to evidence-based diagnoses in paleo-otological studies. Our assumption is in line with clinical and experimental findings indicating that the otic capsule is protected against bone remodeling. LIMITATIONS: Only two specimens were studied. SUGGESTIONS FOR FURTHER RESEARCH: SEM-studies to detect more subtle changes to the promontorial surface.


Assuntos
Otite Média , Paleopatologia , Humanos , Otite Média/diagnóstico , Otite Média/patologia , Osso Temporal/patologia , Remodelação Óssea , Osso e Ossos/patologia
11.
Int J Paleopathol ; 43: 85-92, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37890438

RESUMO

OBJECTIVES: This article considers the position of palaeopathology of ca. 1750AD onward within the subdiscipline of Industrial Archaeology, and reflects upon the relationship between skeletal palaeopathology and textual sources on disease prevalences. METHODS: It draws upon the author's experience in engaging with threat-led archaeology. It synthesises key elements of palaeopathological literature, emphasising contributions to the IJPP VSI 'Changes in Health with the Rise of Industry', and also the broader literature regarding Industrial Archaeology. RESULTS: Industrial Archaeology has seen a recent refocus to include not only a concentration upon technological aspects of industry but also increased emphasis the social context of industrialisation. This movement toward a placement of people as well as machines centre stage has resulted in an environment conducive for paleopathology to make a greater impact upon studies of the period. CONCLUSIONS: Palaeopathologists need to ensure that their biocultural work is orientated toward research goals of broader relevance if the impact of their work is to be maximised. We cannot directly align prevalence data generated from skeletal and and written sources; roles played by these two sources of evidence will depend, inter alia, upon the problems being investigated. SIGNIFICANCE: The success of 'Industrial Palaeopathology' will be measured by the extent to which human remains studies move toward centre stage within the broader discipline of Industrial Archaeology. LIMITATIONS: Multiple perspectives on disciplinary development are possible. Academic traditions, relationships between university- and threat led-sectors, and the opportunities and challenges engendered by working with human remains, differ in different countries.


Assuntos
Restos Mortais , Paleopatologia , Humanos , Paleopatologia/métodos , Reino Unido , Arqueologia
12.
Int J Paleopathol ; 43: 68-71, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37806166

RESUMO

OBJECTIVE: This paper presents the results of a 2019 Paleopathology Association workshop that tested observer agreement on porous cranial lesion morphology and presence using multiple sets of existing guidelines for data collection. MATERIALS: Sixteen conference attendees of varying osteological experience served as observers. Three crania were assigned to each of four published guidelines for identifying and categorizing lesion morphology, for a total of twelve well-preserved human crania from the National Museum of Natural History Biological Anthropology Collections. METHODS: Observers assessed each cranium macroscopically according to its assigned set of guidelines. RESULTS: Observer concordance was higher using scoring guidelines with higher-quality photographs, such as the 2019 guidelines from Rinaldo and colleagues. CONCLUSIONS: Data collection guidelines with high-quality color photos may support greater reliability of researcher-generated data on macroscopic skeletal features. SIGNIFICANCE: The conclusions of any research study are only as reliable as the data on which they are based. This work highlights the need for ongoing practices of quality control in a field in which much data results from individual judgement calls. LIMITATIONS: Observer concordance is not a measure of observer accuracy. Sample size is insufficient to draw broadly generalizable conclusions on the reliability of data collected using the guidelines tested, and conference environments are not a facsimile of research settings. SUGGESTIONS FOR FURTHER RESEARCH: Iterative testing of methodological consistency using larger sample sizes and more non-pathological crania is advised to identify the factors that influence observer discordance and to improve guidelines for qualitative assessments.


Assuntos
Hiperostose , Paleopatologia , Humanos , Paleopatologia/métodos , Porosidade , Reprodutibilidade dos Testes , Hiperostose/patologia , Crânio/patologia
13.
Anthropol Anz ; 80(4): 363-383, 2023 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-37615595

RESUMO

This paper underlines the importance of the small sample effects consideration in paleopathological research providing an example of children from Kyiv Rus' cemeteries dated to the 10th-13th century AD. The study presents data introduction and systematization, i.e., construction of the statistically significant disease profiles combining the analyzed sites according to the distribution of anemia, scurvy, and rickets. Then we present usually provided (often 'associative') interpretations for the obtained results and question their reliability from the perspective of the small samples effects. This leads to the discussion of explanatory limits of bioarcheological research basing on the small sample analysis.


Assuntos
Escorbuto , Criança , Humanos , Reprodutibilidade dos Testes , Escorbuto/patologia , Paleopatologia/métodos , Cemitérios
14.
Future Microbiol ; 18: 681-693, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37584528

RESUMO

The analysis of past epidemics and pandemics, either spontaneous or of human origin, may revise the physical history of microbiota and create a temporal context in our understanding regarding pathogen attributes like virulence, evolution, transmission and disease dynamics. The data of high-tech scientific methods seem reliable, but their interpretation may still be biased when tackling events of the distant past. Such endeavors should be adjusted to other cognitive resources including historical accounts reporting the events of interest and references in alien medical cultures and terminologies; the latter may contextualize them differently from current practices. Thus 'historical microbiology' emerges. Validating such resources requires utmost care, as these may be susceptible to different biases regarding the interpretation of facts and phenomena; biases partly due to methodological limitations.


Bacteria and viruses have always impacted humankind. They do this directly by causing illness or indirectly by destroying crops and threatening livestock. We can learn a lot by studying disease events of the past ­ for example, we can see how bacteria and viruses have changed over time and predict how they might change in the future. This knowledge could be important to understanding present disease events and predicting future ones. In this review, we propose the concept of 'historical microbiology', which encourages collaboration between scientists, doctors, historians and linguists to provide historical, linguistic and cultural context to our scientific understanding of diseases of the past.


Assuntos
Bolsas de Estudo , Paleopatologia , Humanos , Paleopatologia/métodos , Pandemias
15.
Int J Paleopathol ; 41: 117-122, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37192561

RESUMO

OBJECTIVE: To present paleopathological evidence of a congenital anomaly with photographic support and a review that will help scholars to diagnose the condition. MATERIALS: Well-preserved skeletal remains of a child from central Colombia, dated 968-1046 CE. METHODS: Macroscopic examination and computerized axial tomography. RESULTS: Two holes were observed in the skull. CONCLUSIONS: The pathology is consistent with a neural tube defect or an inclusion cyst. SIGNIFICANCE: Neural tube defects and inclusion cysts, in paleopathology, are rarely reported in children. The preservation and origin of the individual make this case valuable. The photographic support and the review is useful for other scholars in the field. LIMITATIONS: It was not possible to determine a single cause. SUGGESTIONS FOR FUTURE RESEARCH: Review cases in identified osteological collections.


Assuntos
Paleopatologia , Crânio , Humanos , Criança , Diagnóstico Diferencial , Crânio/diagnóstico por imagem , Paleopatologia/métodos , América do Sul , Cabeça
16.
Sci Rep ; 13(1): 6968, 2023 04 28.
Artigo em Inglês | MEDLINE | ID: mdl-37117261

RESUMO

Porotic hyperostosis (PH) is a disease that had high prevalence during the Neolithic. Several hypotheses have been suggested to explain the origin of the disease, such as an iron deficiency diet, low B12 intake, malaria caused by Plasmodium spp., low haemoglobin levels or low vitamin D levels. None of these hypotheses have been tested genetically. Here, I calculated different genetic scores to test each hypothesis. Additionally, I calculated a genetic score of bone mineral density as it is a phenotype that seems to be selected in ancient Europeans. I apply these genetic scores on 80 ancient samples, 33 with diagnosed PH. The results seem to suggest anaemia and low bone mineral density as the main cause for this disease. Additionally, Neolithic individuals show the lowest genetic risk score for bone mineral density of all other periods tested here, which may explain the highest prevalence of the porotic hyperostosis during this age.


Assuntos
Anemia , Doenças Ósseas Metabólicas , Hiperostose , Humanos , Crânio , DNA Antigo , Paleopatologia , Anemia/complicações , Hiperostose/genética , Doenças Ósseas Metabólicas/complicações
17.
Am J Biol Anthropol ; 181(2): 326-335, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-36866523

RESUMO

Weighted threshold diagnostic criteria approaches have emerged for diseases that involve skeletal/bony tissue that are readily diagnosed in the field of paleopathology such as Vitamin C deficiency (scurvy), Vitamin D deficiency (rickets) and treponemal disease. These criteria differ from traditional differential diagnosis in that they involve standardized inclusion criteria based on the lesion's specificity to the disease. Here I discuss the limitations and benefits of threshold criteria. I argue that while these criteria will benefit from further revision such as inclusion of lesion severity, and the incorporation of exclusion criteria, threshold diagnostic approaches have considerable value in the future of diagnosis in the field.


Assuntos
Deficiência de Ácido Ascórbico , Raquitismo , Escorbuto , Deficiência de Vitamina D , Humanos , Paleopatologia , Deficiência de Vitamina D/diagnóstico , Escorbuto/diagnóstico
18.
19.
Genes (Basel) ; 14(2)2023 01 24.
Artigo em Inglês | MEDLINE | ID: mdl-36833230

RESUMO

Parasites have affected and coevolved with humans and animals throughout history. Evidence of ancient parasitic infections, particularly, reside in archeological remains originating from different sources dating to various periods of times. The study of ancient parasites preserved in archaeological remains is known as paleoparasitology, and it initially intended to interpret migration, evolution, and dispersion patterns of ancient parasites, along with their hosts. Recently, paleoparasitology has been used to better understand dietary habits and lifestyles of ancient human societies. Paleoparasitology is increasingly being recognized as an interdisciplinary field within paleopathology that integrates areas such as palynology, archaeobotany, and zooarchaeology. Paleoparasitology also incorporates techniques such as microscopy, immunoassays, PCR, targeted sequencing, and more recently, high-throughput sequencing or shotgun metagenomics to understand ancient parasitic infections and thus interpret migration and evolution patterns, as well as dietary habits and lifestyles. The present review covers the original theories developed in the field of paleoparasitology, as well as the biology of some parasites identified in pre-Columbian cultures. Conclusions, as well as assumptions made during the discovery of the parasites in ancient samples, and how their identification may aid in better understanding part of human history, ancient diet, and lifestyles are discussed.


Assuntos
Parasitos , Doenças Parasitárias , Animais , Humanos , Doenças Parasitárias/parasitologia , Paleopatologia/métodos , Dieta , Estilo de Vida
20.
Int J Paleopathol ; 40: 87-92, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-36628890

RESUMO

OBJECTIVE: Septic arthritis is not commonly reported in paleopathology. This study aims to provide a differential diagnosis of septic arthritis by looking at a case from ancient China. We also aim to add to the current literature on septic arthritis in paleopathology. MATERIALS: One adult male skeleton recovered from the Dapuzi Cemetery, Shaanxi, dating to the Western Han Dynasty (3rd century BCE-1st century CE). METHODS: Macroscopic observations were conducted. RESULTS: The lytic appearance and massive new bone formation on the left acetabulum of M142 are compatible with septic arthritis. The hip pathology greatly influenced his stature. The two femur shafts present different degrees of robusticity. He also showed severe osteoarthritis. CONCLUSIONS: The individual suffered from septic arthritis of the hip, of unknown cause, for a long period, which greatly influenced his daily life. Complications included osteoarthritis, shortened stature, and difficulties in walking. SIGNIFICANCE: This study offers a new case of septic arthritis and provides insight into the people who guarded the royal tombs in the West Han Dynasty. LIMITATIONS: The skeleton is not well-preserved, limiting observations of bony changes to other areas of the body.


Assuntos
Artrite Infecciosa , Paleopatologia , Adulto , Humanos , Masculino , China , Acetábulo , Esqueleto
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