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1.
Int. j. clin. health psychol. (Internet) ; 24(1): [100433], Ene-Mar, 2024. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-230376

RESUMO

Background: The exact causal mechanisms of depression remain unclear due to the complexity of the triggers, which has led to limitations in treating depression using modern drugs. High-intensity interval training (HIIT) is as effective as medication in treating depression without toxic side effects. Typically, HIIT requires less time commitment (i.e., shorter exercise duration) and exhibits pronounced benefits on depressive symptoms than other forms of physical exercise. This review summarizes the risk reduction and clinical effects of HIIT for depression and discusses the underlying mechanisms, providing a theoretical basis for utilizing HIIT in treating depression. Methods: A database search was conducted in PubMed, Embase, Web of Science, and Scopus from inception up to October 2022. The methodological quality of the included literature was evaluated by the physiotherapy evidence database (PEDro) scale criteria. The review focused on evaluating the changes in depression risk or symptoms of HIIT interventions in healthy individuals, patients with depression, and patients with other disorders co-morbid with depression. Consequently, the mechanisms associated with depression related HIIT were summarized. Results: A total of 586 participants (52 % female; mean age: 43.58±8.93 years) from 22 studies were included. Implementing HIIT using different exercise types alleviates depressive symptoms in individuals with depression and in individuals with depression who have exhibited comorbidities and reduced depression scale scores in subjects immediately after acute exercise. In addition, the long-interval HIIT and short-interval HIIT in the treatment of patients with cardiovascular or psychiatric disorders may reduce depressive symptoms via complex exercise-related changes on several levels, including by effecting the following measures: releasing monoamines, reducing neuronal death, inducing neurogenesis, modulating the functional...(AU)


Assuntos
Humanos , Masculino , Feminino , Depressão , Inflamação/reabilitação , Fatores de Crescimento Neural , Sistema Hipotálamo-Hipofisário , Treinamento Intervalado de Alta Intensidade , Tratamento Farmacológico
2.
Arch. Soc. Esp. Oftalmol ; 99(3): 109-132, Mar. 2024. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-231137

RESUMO

Con el avance de la terapia contra el cáncer en los últimos años, ha aumentado el conocimiento de los mecanismos involucrados en esta enfermedad, lo que ha supuesto un aumento de la calidad de vida y de la supervivencia de los pacientes con afecciones tumorales anteriormente consideradas incurables o refractarias al tratamiento. El número de fármacos utilizados ha sufrido un aumento exponencial, y a pesar de que la toxicidad implícita es menor que la de la terapia antineoplásica convencional, conllevan la aparición de nuevos efectos adversos asociados, que el oftalmólogo debe reconocer y manejar.(AU)


With the advance of cancer therapy in recent years, the knowledge of the mechanisms involved in this disease has increased, which has meant an increase in the quality of life and survival of patients with tumor pathologies previously considered incurable or refractory to treatment. The number of drugs used has increased exponentially in number, and although the implicit toxicity is lower than that of conventional antineoplastic therapy, they lead to the appearance of new associated adverse effects that the ophthalmologist must recognize and manage.(AU)


Assuntos
Humanos , Masculino , Feminino , Oftalmologia , Efeito Secundário , Anticorpos Monoclonais , Tratamento Farmacológico , Neoplasias , Radioterapia , Edema da Córnea , Fibrose , Baixa Visão
3.
Med. oral patol. oral cir. bucal (Internet) ; 29(2): e232-e240, Mar. 2024. tab, graf
Artigo em Inglês | IBECS | ID: ibc-231227

RESUMO

Background: The tongue has an indispensable role in communication, swallowing and breathing. Tongue cancer treatment involves direct resection of the tumor and surrounding tissue, which can limit many essential functions of the tongue. There are few patient-reported quality of life studies involving tongue cancer exclusively. There is also a lack of data on the outcomes of quality of life regarding different reconstructive methods, adjuvant nonsurgical therapies and other predicting factors. Our objective is to assess the quality of life, functional status, and predicting factors in patients with tongue cancer up to one year after surgical resection. Material and Methods: Thirty-six patients with tongue cancer were prospectively identified between October of 2017 and January 2021. Patients were examined before and one, three, six and twelve months after surgical resection with the validated University of Washington Quality of Life questionnaire (UW-QOL). Data collection included patient age, sex, TNM staging, size of resection, neck dissection, tracheostomy, reconstructive method and adjuvant therapies. Outcome scores were compared using the Friedman test. Multiple linear regression analysis was used to identify the predictors of quality of life and functional status. Results: The use of UWQOL scores as dependent variables revealed the following predicting factors: age, tobacco use, radiotherapy, chemotherapy, reconstruction method and neck dissection. Conclusions: The most relevant findings in our study are that flap reconstruction becomes increasingly necessary when a glossectomy resection is over 45 mm, in order to maintain tongue function. We established that the reconstructive flap type does not influence quality of life in the long term. Also, we have found that cervical sentinel node biopsy provides better quality of life over neck dissection in the first 3 months after surgery. (AU)


Assuntos
Humanos , Neoplasias da Língua , Qualidade de Vida , Traqueotomia , Terapias Complementares , Radioterapia , Tratamento Farmacológico , Tabaco , Terapêutica
4.
Med. oral patol. oral cir. bucal (Internet) ; 29(2): e248-e254, Mar. 2024. graf, tab
Artigo em Inglês | IBECS | ID: ibc-231229

RESUMO

Background: This study retrospectively analyzed the risk factors for oral mucositis (OM) during cetuximab treatment. Material and Methods: We screened patients using cetuximab and retrospectively evaluated the presence of OM based on medical records. We collected information from 2 years of evaluations. Patient medical records were reviewed to obtain data on chemotherapy cycle and dose, sex, age, primary tumor, TNM stage, and head and neck radiotherapy (HNR) history. The X2 test and multinomial logistic regression were used for statistical analysis (SPSS 20.0, p < 0.05). Results: Among 1831 patients, OM was showed in 750 in any grade (41%), during cetuximab treatment. Most patients were female (n=944, 51.6%), <70years-old (n=1149, 62.8%), had larynx cancer (n=789, 43.1%) in T4 (n=579, 47.7%), N0 (n=509, 52.6%) stages. Primary tumor surgery was performed in 1476 (80.6%) patients, radiotherapy in 606 (33.1%) patients and cetuximab protocols most used involved up to four cycles (n=1072, 58.5%) of <400mg (n=996, 54.4%) cetuximab doses. Female (OR [odds ratio] = 2.17, CI95% = 1.26-3.75), >70 years-old patients (OR = 16.02, CI95% = 11.99-21.41), with HHNR (OR = 1.84, 1.41-2.40), treated with >4 cycles (OR = 1.52, CI95% = 1.16-2.01) and high doses of cetuximab (OR = 3.80, CI95% = 2.52-5.71) are the greatest risk factors for OM. Conclusions: Since the clinical benefit of cetuximab in the treatment of older patients is limited and there is a high OM, especially in women with head and neck treated with radiotherapy, high doses and a high number of cetuximab cycles must be administered with caution. (AU)


Assuntos
Humanos , Estomatite , Cetuximab , Tratamento Farmacológico , Sexo , Adenolinfoma , Neoplasias de Cabeça e Pescoço , Radioterapia
5.
Pharm. pract. (Granada, Internet) ; 22(1): 1-14, Ene-Mar, 2024. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-231360

RESUMO

Objectives: This study aimed to compare and correlate plasma and salivary levels of cardiometabolic risk biomarkers’ of pharmacotherapy (appraised using colorimetric assays), adiposity, and atherogenicity indices. Methods: 61 Nascent MetS subjects vs. 30 lean normoglycemic and healthy controls were recruited in Family Medicine outpatient clinics/Jordan University Hospital (a referral medical center). Fasting blood and saliva specimens were collected. Clinical and anthropometric variables were determined along with atherogenecity and adiposity indices. Results: Among nascent MetS (metabolic syndrome) recruits, almost half were normoglycemic, 43% were prediabetic and 8% were diabetic. Pronouncedly Glycemic (FPG and Alc) and lipid parameters (TG, HDL-C and non-HDL-C), adiposity indices (BMI, WHR, WtHR, Conicity-index, BAI, LAP, VAI) and atherogenicity indices (AIP, TC/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C and TG/HDL-C) were higher in the nascent MetS group (P<0.05 vs. controls). Markedly among the plasma cardiometabolic risk biomarkers (P<0.05 vs. controls) in the nascent MetS group, adipolin, cathepsin S, ghrelin, irisin, LBP, leptin, and osteocalcin were higher but plasma FGF1 levels were oddly lower. Significantly (P<0.05 vs. controls) nascent MetS –linked salivary levels of adipolin and LBP were higher as opposed to the lower cathepsin S. Only osteocalcin, amongst 9 metabolic risk biomarkers studied, had remarkably significant correlation between plasma and saliva levels, in both total sample and MetS patients (P<0.05). Markedly in the nascent MetS only group, both plasma and salivary osteocalcin correlated with FPG and A1c (P<0.05); salivary osteocalcin correlated with BMI and LAP (P<0.05). Likewise, in the total sample plasma osteocalcin correlated significantly with BMI, BAI, WHt R, SBP, DBP, TG, LAP, VAI, TG/HDL-C and AIP (P<0.05), while salivary osteocalcin had substantial correlations only with FPG and A1c (P<0.05). Conclusion: Association of nascent MetS-related plasma and salivary osteocalcin levels and clinical characteristics and indices propagate salivary osteocalcin as a non-invasive marker for clinical control of MetS-/preDM.(AU)


Assuntos
Humanos , Masculino , Feminino , Síndrome Metabólica/genética , Osteocalcina/administração & dosagem , Saliva/microbiologia , Estado Pré-Diabético/diagnóstico , Plasma , Biomarcadores , Tratamento Farmacológico , Fator 1 de Crescimento de Fibroblastos , Adiposidade , Lipopolissacarídeos , Leptina , Osteocalcina
6.
Pharm. pract. (Granada, Internet) ; 22(1): 1-7, Ene-Mar, 2024. tab, graf
Artigo em Inglês | IBECS | ID: ibc-231364

RESUMO

Objective: Venous thrombosis (VTE) and arterial thrombosis are two different diseases. Although they differ in causes, types, and treatment, they share many risk factors. Many people are not able to differentiate between them. So assessing the awareness of people toward these two diseases and determining the variables that affect their awareness was the aim of the study. Methods: This is a cross-sectional validated questionnaire which was conducted on social media. It targeted the southern Jordanian public above 18 years between October and December 2022. Results: A total of 630 people participated in the current study. Only 42.2% knew the cause of arterial thrombosis compared to 58.7% in case of venous thrombosis. More than half (63.2%) of the participants knew that there is a difference between venous and arterial thrombosis. DVT (36.8%) and PE (23%) were correctly identified as types of VTE, while only myocardial infarction was identified as a type of arterial thrombosis by 52.2% of respondents. About 69.5% and 80.2% of respondents think that venous and arterial thrombosis are fatal, respectively. Regarding the socio-demographic variables that affect the awareness of the public, old age, high educational level, working, and earning at least 500 JD per month were significantly associated with better awareness of the study population about venous and arterial thrombosis with a p-value of 0.0027, < 0.001, 0.0017, and < 0.001 respectively. Conclusion: The current study reveals that there is a lack of awareness about VTE and arterial thrombosis and the difference between them among the southern Jordanian public. VTE and arterial thrombosis are preventable diseases, so more attention should be given by increasing the educational campaign and the initiatives of public health about the difference between them in terms of signs and symptoms, risk factors, and complications.(AU)


Assuntos
Humanos , Masculino , Feminino , Trombose das Artérias Carótidas/diagnóstico , Trombose Venosa/diagnóstico , Conscientização , Trombose/classificação , Conhecimento , Jordânia , Farmácia , Tratamento Farmacológico , Inquéritos e Questionários , Estudos Transversais
7.
Hipertens. riesgo vasc ; 41(1): 40-57, Ene-Mar, 2024. tab
Artigo em Inglês | IBECS | ID: ibc-ADZ-275

RESUMO

Objective: Review of some of the best-known biological and non-biological complementary/alternative therapies/medicines (CAM) and their relationship with blood pressure (BP) and hypertension (HT). Search strategy: Narrative review assessing a recent series of systematic reviews, meta-analyses, and clinical trials published in recent years, focusing on the effects of CAM on BP and HT. Selection of studies: We searched EMBASE, MEDLINE, Cochrane Library and Google Scholar, obtaining a total of 4336 articles, finally limiting the search to 181 after applying filters. Synthesis of results: Some studies on biological therapies show some usefulness in BP reduction with an adequate benefit–risk balance, although there is a scarcity of high-quality trials that support these results. Some mind-body therapies have shown hypothetical benefit; in contrast, others lack robust evidence. Conclusions: Although some therapies present a reasonable risk–benefit ratio, they should in no case replace pharmacological treatment when indicated.(AU)


Objetivo: Revisar algunas de las más conocidas terapias/medicinas biológicas y no biológicas complementarias/alternativas (MCA), y su relación con la presión arterial (PA) e hipertensión arterial (HTA). Estrategia de búsqueda: Revisión narrativa en la que se valoraron una serie reciente de revisiones sistemáticas, metaanálisis y ensayos clínicos publicados en los últimos años, centrada en los efectos de la MCA sobre la PA y HTA. Selección de estudios: Se realizaron búsquedas en EMBASE, MEDLINE, Cochrane Library y Google Scholar, obteniéndose un total de 4.336 artículos, limitándose finalmente a 181 tras aplicar filtros. Síntesis de resultados: Algunos trabajos sobre terapias biológicas parecen demostrar cierta utilidad en reducción de la PA con adecuado balance beneficio/riesgo, aunque existe escasez de ensayos de alta calidad que avalen estos resultados. Algunas terapias cuerpo/mente han mostrado un hipotético beneficio; en cambio, otras carecen de evidencia robusta. Conclusiones: Aunque algunas terapias presentan una relación riesgo/beneficio razonable, no deberían sustituir en ningún caso al tratamiento farmacológico cuando este esté indicado.(AU)


Assuntos
Humanos , Masculino , Feminino , Terapias Complementares , Hipertensão , Pressão Arterial , Terapia Biológica , Tratamento Farmacológico , Terapêutica
8.
J. physiol. biochem ; 80(1): 81-97, Feb. 2024. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-229942

RESUMO

DERL2 (derlin 2) is a critical component of the endoplasmic reticulum quality control pathway system whose mutations play an important role in carcinogenesis, including cholangiocarcinoma (CHOL). However, its role and its underlying mechanism have yet to be elucidated. Herein, we revealed that DERL2 was highly expressed in CHOL and considered as an independent prognostic indicator for inferior survival in CHOL. DERL2 ectopically expressed in CHOL cells promoted cell proliferation and colony formation rates, and depleting DERL2 in CHOL cells curbed tumor growth in vitro and in vivo. More interestingly, the knockout of DERL2 augmented the growth-inhibitory effect of gemcitabine chemotherapy on CHOL cells by inducing cell apoptosis. Mechanistically, we discovered that DERL2 interacted with BAG6 (BAG cochaperone 6), thereby extending its half-life and reinforcing the oncogenic role of BAG6 in CHOL progression. (AU)


Assuntos
Colangiocarcinoma , Resistencia a Medicamentos Antineoplásicos , Carcinogênese , Tratamento Farmacológico
9.
Nutr. hosp ; 41(1): 112-121, Ene-Feb, 2024. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-230890

RESUMO

Objective: the aim of this study is to evaluate the relationship between serum vitamin D and B12 levels, nutritional levels, depression, and anxiety in adult cancer patients before and after chemotherapy. Methods: a case-controlled study was carried out on 44 patients who were diagnosed with cancer and applied to the Chemotherapy Unit for treatment (patient group, PG) and 44 volunteer individuals (control group, CG) with similar characteristics to the age and gender-matched patient group but with no diagnosis of cancer. Results: the average age of individuals in PG is 52.50 ± 12.21 years and for those in CG is 52.84 ± 10.98 years. Serum D and B12 levels in the first cure in individuals in PG are higher than in the last treatment (p > 0.05). It was determined that vitamin C taken with a daily diet reduces the risk of cancer (OR: 0.920, 95 % CI: 0.899-0.942, p = 0.042). No correlation was found between depression and anxiety scores of both groups and serum vitamin D and B12 levels (p > 0.05). It was determined that the Beck Anxiety Inventory (BAI) score increased with decrease in body mass index (BMI) (β = 0.311, p = 0.040) and serum vitamin B12 level (β = -0.406, p = 0.006). In addition, it was found that the increase in the Patient-Generated Subjective Global Assessment (PG-SGA) score, which reflects the nutritional status of cancer patients, worsened the level of anxiety (β = 0.389, p = 0.009). Conclusions: as stated in the findings of the study, chemotherapy treatment mediated the development of anxiety in cancer patients by changing the vitamin B12 levels and anthropometric characteristics with its negative effect on nutritional status. It should be ensured that cancer patients treated with chemotherapy follow a healthy and balanced diet plan that is suitable for their needs and has adequate vitamin and mineral content.(AU)


Objetivo: el objetivo de este estudio es evaluar la relación entre los niveles séricos de vitamina D y B12, el estado nutricional y el estado de depresión y de ansiedad antes y después de la quimioterapia en pacientes adultos con cáncer que están recibiendo quimioterapia. Métodos: se realizó un estudio de casos controlados en 44 pacientes diagnosticados de cáncer (grupo de pacientes, GP) que solicitaron tratamiento a la Unidad de Quimioterapia y 44 voluntarios sanos (grupo de control, GC) sin diagnóstico de cáncer y que tenían características similares al grupo GP en cuanto a edad y sexo. Resultados: la edad media de los individuos del GP fue de 52,50 ± 12,21 años, mientras que la del GC fue de 52,84 ± 10,98 años. Los niveles séricos de vitamina D y B12 en individuos del GP en el primer ciclo fueron más altos que en el último ciclo (p > 0,05). Se determinó que la vitamina C tomada en la dieta diaria reduce el riesgo de cáncer (OR: 0,920, IC del 95 %: 0,899-0,942, p = 0,042). No se detectó una correlación entre las puntuaciones de depresión y ansiedad de ambos grupos y los niveles séricos de vitamina D y B12 (p > 0,05). Se determinó que la puntuación Inventario de Ansiedad de Beck (BAI) aumentó con la disminución del índice de masa corporal (IMC) (β = 0,311, p = 0,040) y el nivel sérico de vitamina B12 (β = -0,406, p = 0,006). Además, se objetivó que el aumento en la puntuación en el Patient-Generated Subjective Global Assessment (PG-SGA), que refleja el estado nutricional de los pacientes con cáncer, empeoró el nivel de ansiedad (β = 0,389, p = 0,009). Conclusión: como se indica en los hallazgos del estudio, el tratamiento con quimioterapia medió en el desarrollo de ansiedad en pacientes con cáncer al cambiar los niveles de vitamina B12 y las características antropométricas con su efecto negativo en el estado nutricional...(AU)


Assuntos
Humanos , Masculino , Feminino , Depressão , Ansiedade , Neoplasias , Vitamina D/administração & dosagem , Vitamina B 12/administração & dosagem , Estado Nutricional , Tratamento Farmacológico , Estudos de Casos e Controles , Fatores de Risco , Ciências da Nutrição
10.
J. physiol. biochem ; 80(1): 81-97, Feb. 2024. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-EMG-567

RESUMO

DERL2 (derlin 2) is a critical component of the endoplasmic reticulum quality control pathway system whose mutations play an important role in carcinogenesis, including cholangiocarcinoma (CHOL). However, its role and its underlying mechanism have yet to be elucidated. Herein, we revealed that DERL2 was highly expressed in CHOL and considered as an independent prognostic indicator for inferior survival in CHOL. DERL2 ectopically expressed in CHOL cells promoted cell proliferation and colony formation rates, and depleting DERL2 in CHOL cells curbed tumor growth in vitro and in vivo. More interestingly, the knockout of DERL2 augmented the growth-inhibitory effect of gemcitabine chemotherapy on CHOL cells by inducing cell apoptosis. Mechanistically, we discovered that DERL2 interacted with BAG6 (BAG cochaperone 6), thereby extending its half-life and reinforcing the oncogenic role of BAG6 in CHOL progression. (AU)


Assuntos
Colangiocarcinoma , Resistencia a Medicamentos Antineoplásicos , Carcinogênese , Tratamento Farmacológico
11.
Rev. esp. enferm. dig ; 116(3): 173-174, 2024. ilus
Artigo em Inglês | IBECS | ID: ibc-231488

RESUMO

There are multiple causes of secondary sclerosing cholangitis (SSC), including mechanical obstruction, ischemia, congenital abnormalities, cholangiopathy of the critically ill patient and rarely, chemotherapy (1,2). We present the case of a 52-year-old female with a history of left breast invasive ductal carcinoma treated with neoadjuvant chemotherapy (adriamycin, cyclophosphamide and paclitaxel), surgery and radiotherapy in March 2021. She was admitted in July 2022 due to painless jaundice and pruritus with marked serum cholestasis. Magnetic resonance cholangiopancreatography showed multiple strictures and dilatations involving the intra and extrahepatic bile ducts (Figure 1.A), without any extrinsic stenotic cause. Findings were confirmed by endoscopic retrograde cholangiopancreatography (ERCP) with cholangioscopy (Figure 1.B). Biopsies were negative for malignancy and IgG4 disease. In addition, autoantibodies were negative and serum IgG4 levels were normal. Due to these findings and the history of recent chemotherapy, the patient was diagnosed with paclitaxel-induced sclerosing cholangitis, initiating treatment with ursodeoxycholic acid. Over the following two months, she suffered two episodes of Klebsiella Pneumoniae bacteraemia due to acute cholangitis. Dilatation and placement of plastic stents in both biliary trees were performed and prophylactic antibiotherapy was started. The patient had a poor evolution and was not candidate for liver transplantation on account of a recent neoplasia. She died six months later due to sepsis secondary to multiple hepatic abscesses. (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Colangite Esclerosante/diagnóstico por imagem , Tratamento Farmacológico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Espectroscopia de Ressonância Magnética
12.
Rev Enferm UFPI ; 12(1): e4227, 2023-12-12. tab
Artigo em Inglês, Português | LILACS, BDENF - Enfermagem | ID: biblio-1523674

RESUMO

Objetivo: Identificar as necessidades de aprendizagem de graduandos de enfermagem sobre segurança do paciente e segurança medicamentosa. Métodos: Estudo descritivo, transversal, desenvolvido no período de março de 2019 a dezembro de 2020, com amostra não probabilística e intencional constituída por 45 graduandos de enfermagem. Os dados foram analisados por meio de estatística descritiva. Resultados: Houve predomínio de estudantes do sexo feminino (73,3%) com renda familiar entre 1 e 2 salários mínimos. Todos confirmaram ter acesso à internet, com frequência diária de uso de participantes (93,3%). O smartfone foi o aparelho mais utilizado para acesso à internet (77,8%), tendo o domicílio como local predominante de acesso (80,0%). Sobre as necessidades de aprendizagem acerca da segurança do paciente e da segurança medicamentosa, destacou-se a classificação "essencial" dentre as questões avaliadas. Conclusão: Identificaram-se como as principais necessidades de aprendizagem dos participantes: atuar em equipe de forma eficaz, compreender os sistemas e o efeito da complexidade dos cuidados ao paciente e definição dos conceitos-chaves. Junto a isso, verificaram-se fragilidades de diferenciação entre os termos comuns no processo de administração de medicamentos. Descritores: Educação em Enfermagem; Segurança do Paciente; Tratamento Farmacológico; Tecnologia.


Objective: To identify the learning needs of undergraduate nursing students about patient safety and medication safety.Methods: Descriptive and cross-sectional study, developed from March 2019 to December 2020, with a non-probabilistic and intentional sample consisting of 45 undergraduate nursing students. Data were analyzed using descriptive statistics.Results: There was a predominance of female students (73.3%) with family income between 1 and 2 minimum wages. All confirmed having access to the internet, with a daily frequency of use by participants (93.3%). The smartphone was the most used device to access the internet (77.8%), with the home being the predominant place of access (80.0%). Regarding the learning needs about patient safety and medication safety, the classification "essential" stood out among the evaluated questions.Conclusion:The main identified learning needs of the participants were: working effectively as part of a team, understanding the systems and the effect of the complexity of patient care and defining the key concepts. In addition to that, there were weaknesses in differentiating between common terms in the medication administration process. Descriptors: Education, Nursing; Patient Safety; Drug Therapy; Technology.


Assuntos
Tecnologia , Tratamento Farmacológico , Educação em Enfermagem , Segurança do Paciente
13.
Respirar (Ciudad Autón. B. Aires) ; 15(4): 263-278, Diciembre 2023.
Artigo em Espanhol | LILACS, UNISALUD, BINACIS | ID: biblio-1518685

RESUMO

Las enfermedades respiratorias crónicas avanzadas son prevalentes y producen deterioro de la calidad de vida, en particular la enfermedad pulmonar obstructiva crónica (EPOC), las enfermedades pulmonares intersticiales difusas (EPID) y las enfermedades neuromusculares progresivas con compromiso diafragmático (ENM). Quienes las padecen presentan síntomas persistentes que no son siempre adecuada-mente controlados por los tratamientos recomendados por las guías clínicas de mane-jo. El tratamiento paliativo de los síntomas persistentes es un punto relevante y suelen presentarse barreras para su implementación.Este artículo ofrece una revisión narrativa sobre una perspectiva latinoamericana acerca del rol de los cuidados paliativos en enfermedades respiratorias avanzadas.


Advanced chronic respiratory diseases are prevalent and cause deterioration in qual-ity of life, particularly chronic obstructive pulmonary disease (COPD), diffuse intersti-tial lung diseases (ILD) and progressive neuromuscular diseases with diaphragmatic involvement (NMD). Those who suffer from them usually present persistent symptoms that are not always adequately controlled by the treatments recommended by the clinical management guidelines. Palliative treatment of persistent symptoms is a relevant point, but the pal-liative approach usually presents barriers to its implementation.This article offers a narrative review over Latin American perspective on the role of pal-liative care in advanced respiratory diseases.


Assuntos
Humanos , Cuidados Paliativos , Doenças Respiratórias/terapia , Doenças Pulmonares Intersticiais/terapia , Doença Pulmonar Obstrutiva Crônica/terapia , Doenças Neuromusculares/terapia , Prevalência , Cuidadores , Tratamento Farmacológico , Manejo da Dor
15.
Farm. hosp ; 47(6): 254-260, Noviembre - Diciembre 2023. tab, graf
Artigo em Inglês, Espanhol | IBECS | ID: ibc-227537

RESUMO

Objetivos el seguimiento farmacoterapéutico (SFT) realizado por el farmacéutico clínico puede enmarcarse dentro de 3 actividades: la identificación, la resolución y la prevención de eventos adversos a medicamentos. Estas deben ajustarse a los requerimientos y los recursos de cada institución, generando la necesidad de desarrollar procedimientos que aumenten la eficiencia del SFT y garanticen la seguridad del paciente. Los farmacéuticos clínicos de la Red de Salud UC-CHRISTUS Chile desarrollamos un Proceso Estandarizado de Evaluación Farmacoterapéutica (PEEF). El objetivo principal del estudio fue evaluar el impacto de esta herramienta en términos del número de evaluaciones e intervenciones de los farmacéuticos clínicos y secundariamente determinar el ahorro de costos potenciales y directos asociados a las intervenciones en la Unidad de Cuidados Intensivos (UCI). Método estudio cuasi-experimental que evaluó la frecuencia y tipo de evaluaciones e intervenciones realizadas por los farmacéuticos clínicos en unidades de pacientes adultos de la Red UC-CHRISTUS, previo y posterior a la utilización del PEEF. La distribución de variables se evaluó mediante el test Shapiro–Wilk, la asociación entre el uso del PEEF y el número de evaluaciones e intervenciones fue realizada mediante el test Chi cuadrado. La evaluación de costos asociados a las intervenciones del farmacéutico clínico en UCI se realizó utilizando la metodología propuesta por Hammond et al.10. Resultados el total de pacientes evaluados pre- y pos-PEEF fue de 1.781 y 2.129, respectivamente. Las evaluaciones e intervenciones en el periodo pre-PEEF fueron 5.209 y 2.246, en el periodo pos-PEEF fueron 6.105 y 2.641, respectivamente. El aumento de las evaluaciones como de las intervenciones fue significativo solo en las unidades de mayor complejidad. La reducción potencial de costos estimados en el periodo pos-PEEF en UCI fue de 492.805 dólares americanos. ... (AU)


Objectives The Pharmacotherapeutic follow-up program (PFU) carried out by the clinical pharmacist can be categorized within 3 fundamental activities; identification, resolution and prevention of adverse drug events. These must be adjusted to the requirements and resources of each institution, developing procedures to increase PFU efficiency and to guarantee patient safety. The clinical pharmacists of UC-CHRISTUS Healthcare Network developed a Standardized Pharmacotherapeutic Evaluation Process (SPEP). The main goal of our study is to evaluate the impact of this tool through the pharmacist evaluation number and pharmacist interventions number. Secondarily to determine the potential and direct cost savings associated with the pharmacist interventions in an Intensive care unit (ICU). Methods A quasi-experimental study evaluated the frequency and type of pharmacist evaluation and pharmacist interventions performed by clinical pharmacists in adult patients units of UC-CHRISTUS Healthcare Network, before and after the implementation of SPEP. The distribution of variables was evaluated using the Shapiro–Wilk test and the association between the use of SPEP and the pharmacist evaluation and pharmacist interventions number was performed using the Chi-square test. The cost evaluation associated with pharmacist interventions in the ICU was carried out using methodology proposed by Hammond et al. Results A total number of 1,781 patients was evaluated before and 2,129 after the SPEP. The pharmacist evaluation and pharmacist interventions number in the before-SPEP period were 5,209 and 2,246. In the after-SPEP period were 6,105 and 2,641, respectively. The increase in both the pharmacist evaluation and pharmacist interventions number was significant only in critical care patients. The potential cost saving in after-SPEP period in the ICU was USD 492,805.... (AU)


Assuntos
Humanos , Farmacêuticos/normas , Tratamento Farmacológico/normas , Tratamento Farmacológico/tendências , Monitoramento de Medicamentos , Assistência Farmacêutica , Serviços Comunitários de Farmácia
16.
Farm. hosp ; 47(6): t289-t293, Noviembre - Diciembre 2023. tab
Artigo em Inglês, Espanhol | IBECS | ID: ibc-227542

RESUMO

Objetivo las náuseas y los vómitos inducidos por la quimioterapia siguen siendo un reto importante para los pacientes que recibieron un trasplante de células madre hematopoyéticas. Este estudio tiene como objetivo sintetizar la evidencia disponible sobre los regímenes de profilaxis antiemética en los pacientes con neoplasias hematológicas que recibieron un trasplante de células madre hematopoyéticas, con el fin de identificar el mejor estándar de cuidado. Métodos se llevará a cabo una revisión sistemática utilizando las bases de datos MEDLINE a través de PubMed, EMBASE, Clinical-Trials.gov y Cochrane. Se considerarán los estudios escritos en inglés, francés, italiano o español. Después de seleccionar los estudios de acuerdo con los criterios de inclusión y exclusión, 2 revisores independientes extraerán los datos y evaluarán el riesgo de sesgo en los artículos seleccionados. Este protocolo se ha elaborado de acuerdo con las recomendaciones de las guías PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols). Este protocolo está registrado en PROSPERO (Prospective Register of Ongoing Systematic Reviews) CRD42023406380. Discusión las náuseas y los vómitos inducidos por la quimioterapia son un efecto secundario incapacitante que supone un reto importante para los pacientes con neoplasias hematológicas. A pesar de la publicación de diversas guías sobre profilaxis antiemética, ninguna de ellas incluye recomendaciones específicas para cada régimen de quimioterapia. Por lo tanto, analizar los regímenes de profilaxis antiemética primaria en los pacientes con neoplasias hematológicas que recibieron un trasplante de progenitores hematopoyéticos sería valioso para mejorar la calidad de vida de estos pacientes. (AU)


Objective Chemotherapy-induced nausea and vomiting continue to pose a significant challenge for patients undergoing hematopoietic stem cell transplantation. This study aims to synthesize available evidence on antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation, in order to identify the best standard of care. Methods A systematic review will be conducted using MEDLINE via PubMed, EMBASE, ClinicalTrials.gov., and Cochrane databases. Studies written in English, French, Italian or Spanish will be considered. After screening the literature according to the inclusion and exclusion criteria, two independent reviewers will extract data and assess the risk of bias in eligible articles. This protocol has been prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. This protocol is registered in the Prospective Register of Ongoing Systematic Reviews (PROSPERO) CRD42023406380. Discussion Chemotherapy-induced nausea and vomiting is a debilitating side effect that presents a significant challenge for patients with hematologic malignancies. Despite the publication of various guidelines, none of them includes specific recommendations for each chemotherapy regimen. Therefore, analyzing the primary antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation would be valuable in enhancing patients' quality of life. (AU)


Assuntos
Humanos , Ciências da Saúde , Náusea e Vômito Pós-Operatórios/terapia , Antieméticos/administração & dosagem , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Tratamento Farmacológico
17.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 67(6): 560-575, Nov-Dic. 2023. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-227631

RESUMO

La resección en bloque de metástasis en columna vertebral ha sido objeto de estudio en la literatura médica debido a su impacto en la calidad de vida de los pacientes y su efectividad en el control local de la enfermedad. Este análisis bibliográfico examina los hallazgos y perspectivas de estudios publicados en relación con la resección en bloque de oligometástasis vertebrales. La técnica, que implica la extirpación completa del tumor junto con una porción del hueso circundante, ha demostrado mejorar el control local del tumor, reducir la recurrencia y potencialmente prolongar la supervivencia de los pacientes en comparación con las técnicas convencionales de descompresión y estabilización. Sin embargo, la resección en bloque también presenta riesgos y complicaciones, como la morbilidad quirúrgica y el mayor tiempo de recuperación. La selección adecuada de pacientes, la planificación preoperatoria y el enfoque multidisciplinario son fundamentales para optimizar los resultados. A medida que se desarrollan nuevas técnicas y avances en el tratamiento adyuvante, la resección en bloque de oligometástasis vertebrales sigue siendo un área de interés en la investigación oncológica.(AU)


En bloc resection of vertebral metastases has been the subject of study in medical literature due to its impact on patients’ quality of life and effectiveness in local disease control. This bibliographic analysis examines the findings and perspectives of published studies concerning en bloc resection of oligometastases in the spine. The technique, which involves the complete removal of the tumour along with a portion of the surrounding bone, has been shown to improve local tumour control, reduce recurrence, and potentially prolong patient survival compared to conventional decompression and stabilization techniques. However, en bloc resection also presents risks and complications, such as surgical morbidity and extended recovery time. Appropriate patient selection, preoperative planning, and a multidisciplinary approach are essential to optimize outcomes. As new techniques and advances in adjuvant treatment develop, en bloc resection of oligometastases in the spine remains an area of interest in oncological research.(AU)


Assuntos
Humanos , Masculino , Feminino , Neoplasias da Coluna Vertebral/terapia , Neoplasias Ósseas/terapia , Qualidade de Vida , Radioterapia , Tratamento Farmacológico , Procedimentos Cirúrgicos Operatórios , Traumatologia , Procedimentos Ortopédicos , Ortopedia , Coluna Vertebral , Neoplasias/terapia , Terapêutica , Neoplasias da Coluna Vertebral/cirurgia
18.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 67(6): S560-S575, Nov-Dic. 2023. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-227632

RESUMO

La resección en bloque de metástasis en columna vertebral ha sido objeto de estudio en la literatura médica debido a su impacto en la calidad de vida de los pacientes y su efectividad en el control local de la enfermedad. Este análisis bibliográfico examina los hallazgos y perspectivas de estudios publicados en relación con la resección en bloque de oligometástasis vertebrales. La técnica, que implica la extirpación completa del tumor junto con una porción del hueso circundante, ha demostrado mejorar el control local del tumor, reducir la recurrencia y potencialmente prolongar la supervivencia de los pacientes en comparación con las técnicas convencionales de descompresión y estabilización. Sin embargo, la resección en bloque también presenta riesgos y complicaciones, como la morbilidad quirúrgica y el mayor tiempo de recuperación. La selección adecuada de pacientes, la planificación preoperatoria y el enfoque multidisciplinario son fundamentales para optimizar los resultados. A medida que se desarrollan nuevas técnicas y avances en el tratamiento adyuvante, la resección en bloque de oligometástasis vertebrales sigue siendo un área de interés en la investigación oncológica.(AU)


En bloc resection of vertebral metastases has been the subject of study in medical literature due to its impact on patients’ quality of life and effectiveness in local disease control. This bibliographic analysis examines the findings and perspectives of published studies concerning en bloc resection of oligometastases in the spine. The technique, which involves the complete removal of the tumour along with a portion of the surrounding bone, has been shown to improve local tumour control, reduce recurrence, and potentially prolong patient survival compared to conventional decompression and stabilization techniques. However, en bloc resection also presents risks and complications, such as surgical morbidity and extended recovery time. Appropriate patient selection, preoperative planning, and a multidisciplinary approach are essential to optimize outcomes. As new techniques and advances in adjuvant treatment develop, en bloc resection of oligometastases in the spine remains an area of interest in oncological research.(AU)


Assuntos
Humanos , Masculino , Feminino , Neoplasias da Coluna Vertebral/terapia , Neoplasias Ósseas/terapia , Qualidade de Vida , Radioterapia , Tratamento Farmacológico , Procedimentos Cirúrgicos Operatórios , Traumatologia , Procedimentos Ortopédicos , Ortopedia , Coluna Vertebral , Neoplasias/terapia , Terapêutica , Neoplasias da Coluna Vertebral/cirurgia
19.
Rev. esp. enferm. dig ; 115(12): 679-681, Dic. 2023.
Artigo em Inglês, Espanhol | IBECS | ID: ibc-228701

RESUMO

El sobrecrecimiento bacteriano intestinal (SIBO, por sus siglas en inglés) es una entidad descrita desde hace varias décadas, pero que en los últimos años ha cobrado un especial interés por parte de los profesionales médicos y por la población general, probablemente por el aumento de la disponibilidad de pruebas diagnósticas y por la extensa difusión que se le ha dado a esta enfermedad a través de los medios de comunicación y redes sociales. En vista de la gran cantidad de información disponible en la actualidad y en ocasiones discrepante, entre la Sociedad Española de Patología Digestiva (SEPD) y la Asociación Española de Neurogastroenterología y Motilidad (ASENEM) hemos realizado un documento de posicionamiento para establecer líneas de diagnóstico y tratamiento del SIBO con la información científica actualizada.(AU)


Assuntos
Humanos , Masculino , Feminino , Doenças do Sistema Digestório/diagnóstico , Intestino Delgado/parasitologia , Bactérias , Gastroenteropatias/complicações , Tratamento Farmacológico , Diagnóstico por Imagem
20.
Rev. esp. salud pública ; 97: e202312108, Dic. 2023. tab
Artigo em Espanhol | IBECS | ID: ibc-229753

RESUMO

Fundamentos: Desde 2003, el Instituto Nacional del Cáncer (NCI) de los Estados Unidos de América ha sido uno de los líderes mundiales en la clasificación de los Efectos Adversos (EA). Actualmente, los teléfonos inteligentes permiten, entre otras muchas cosas, la monitorización de estos EA de la quimioterapia desde el domicilio para mejorar la seguridad y la calidad de vida de los pacientes. El objetivo de este estudio fue realizar un análisis comparativo descriptivo del contenido de los EA de la aplicación Abeona Health® y la última versión de los CTCAE (Common Terminology Criteria for Adverse Events). Métodos: Se utilizó la app Abeona Health® y la guía CTCAE v5. Posteriormente, se analizaron los EA más recurrentes en el tratamiento quimioterápico, según la NCI y la Sociedad Española de Oncología Médica (SEOM) y, finalmente, si los pacientes podían identificarlos. Resultados: El CTCAE v5 recoge 837 EA, donde 225 son signos y síntomas. El NCI clasifica cincuenta y cinco signos y síntomas como los más recurrentes, y la SEOM dieciséis, de los cuales quince coinciden con el NCI. La aplicaciónAbeona Health® dispone de siete EA, y todos se incluyen en el CTCAE v5. De estos siete, seis aparecen en las listas de EA más recurrentes del NCI y cuatro en la de la SEOM, todos ellos identificables por el paciente. Conclusiones: Laapp de Abeona Health® se considera adecuada para la participación del paciente en su autocuidado, si biense podrían ampliar algunos campos.(AU)


Bbackground: Since 2003, the National Cancer Institute (NCI) of the United States of America has been one of the world leaders in classifying adverse effects (AEs). Currently, smartphones allow, among many other things, the monitoring of these AEs of chemotherapy from home to improve the safety and quality of life of patients. The aim was to perform a descriptive comparative analysis of the AEs content of the Abeona Health® app and the latest version of the CTCAE (Common Terminology Criteria for Adverse Events). Methods: The Abeona Health® app and the CTCAE v5 guide were used. Subsequently, the most recurrent AEs in the existing chemotherapy treatment were analysed according to the NCI and the Spanish Society of Medical Oncology (SEOM) and finally, whether patients could identify them. Results: The CTCAE v5 (collects 837 AEs), where two hundred and twenty-five are signs and symptoms. The NCI classifies fifty-five signs and symptoms as the most recurrent, and the SEOM sixteen, of which fifteen coincide with the NCI. The Abeona Health® application has seven AEs, all included in the CTCAE v5. Of these seven, six appear in the NCI lists of most recurrent AEs and four in the SEOM list, all identifiable by the patient. Conclusions: TheAbeona Health® app is considered adequate for the patient participation in their self-care, although somefields could be expanded.(AU)


Assuntos
Humanos , Masculino , Feminino , Telemedicina , Tecnologia Biomédica , Toxicidade , Tratamento Farmacológico , Aplicativos Móveis , Neoplasias/tratamento farmacológico , Oncologia , Saúde Pública , Enfermagem/tendências , Tecnologia da Informação , Epidemiologia Descritiva , Smartphone/tendências
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