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1.
J Bodyw Mov Ther ; 37: 360-365, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38432829

RESUMO

INTRODUCTION: Effects on strength performance and muscle activation in the contralateral limb have been observed after training with the ipsilateral limb (IL). Cross fatigue effects in the contralateral limb (CL) can occur at intervals of up to 48 h after a training session performed with the ipsilateral limb. The objective of this study was to verify the effect of a training session in the ipsilateral limb, on the strength and activation of the muscles in the contralateral limb also submitted to the training protocol. METHODS: 10 untrained men (mean ± SD: age = 23.7 ± 4.9 years) performed unilateral knee extension with both limbs in equated protocols, in two conditions with different intervals between limbs - 20 min and 24 h. RESULTS: There were no differences in the comparison of the force produced between the pre x post interventions with the CL limb, as well as in the activation of the quadriceps during its performance. These results were similar for the two different intervals between the protocols. CONCLUSION: It was concluded that when the CL member performs the protocol after the IL, the responses in the CL depend mainly on the requirement imposed on the protocol performed by this member, without influence of the training protocol performed previously with the IL member.


Assuntos
Exercício Físico , Fadiga , Masculino , Humanos , Adolescente , Adulto Jovem , Adulto , Articulação do Joelho , Músculo Quadríceps , Descanso
2.
Proc Natl Acad Sci U S A ; 121(12): e2309232121, 2024 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-38466844

RESUMO

Sociality is a defining feature of the human experience: We rely on others to ensure survival and cooperate in complex social networks to thrive. Are there brain mechanisms that help ensure we quickly learn about our social world to optimally navigate it? We tested whether portions of the brain's default network engage "by default" to quickly prioritize social learning during the memory consolidation process. To test this possibility, participants underwent functional MRI (fMRI) while viewing scenes from the documentary film, Samsara. This film shows footage of real people and places from around the world. We normed the footage to select scenes that differed along the dimension of sociality, while matched on valence, arousal, interestingness, and familiarity. During fMRI, participants watched the "social" and "nonsocial" scenes, completed a rest scan, and a surprise recognition memory test. Participants showed superior social (vs. nonsocial) memory performance, and the social memory advantage was associated with neural pattern reinstatement during rest in the dorsomedial prefrontal cortex (DMPFC), a key node of the default network. Moreover, it was during early rest that DMPFC social pattern reinstatement was greatest and predicted subsequent social memory performance most strongly, consistent with the "prioritization" account. Results simultaneously update 1) theories of memory consolidation, which have not addressed how social information may be prioritized in the learning process, and 2) understanding of default network function, which remains to be fully characterized. More broadly, the results underscore the inherent human drive to understand our vastly social world.


Assuntos
Mapeamento Encefálico , Aprendizado Social , Humanos , Córtex Pré-Frontal/diagnóstico por imagem , Encéfalo , Cognição , Descanso , Imageamento por Ressonância Magnética/métodos
4.
Sci Rep ; 14(1): 6616, 2024 03 19.
Artigo em Inglês | MEDLINE | ID: mdl-38503818

RESUMO

Value alignment, the process of ensuring that artificial intelligence (AI) systems are aligned with human values and goals, is a critical issue in AI research. Existing scholarship has mainly studied how to encode moral values into agents to guide their behaviour. Less attention has been given to the normative questions of whose values and norms AI systems should be aligned with, and how these choices should be made. To tackle these questions, this paper presents the STELA process (SocioTEchnical Language agent Alignment), a methodology resting on sociotechnical traditions of participatory, inclusive, and community-centred processes. For STELA, we conduct a series of deliberative discussions with four historically underrepresented groups in the United States in order to understand their diverse priorities and concerns when interacting with AI systems. The results of our research suggest that community-centred deliberation on the outputs of large language models is a valuable tool for eliciting latent normative perspectives directly from differently situated groups. In addition to having the potential to engender an inclusive process that is robust to the needs of communities, this methodology can provide rich contextual insights for AI alignment.


Assuntos
Inteligência Artificial , Idioma , Humanos , Princípios Morais , Descanso
5.
Aerosp Med Hum Perform ; 95(4): 206-213, 2024 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-38486319

RESUMO

INTRODUCTION: Sleep inertia is the transition state during which alertness and cognitive performance are temporarily impaired after awakening. Magnitude and time course of sleep inertia are characterized by high individual variability with large differences between the cognitive functions affected. This period of impairment is of concern to pilots, who take sleep or nap periods during on-call work hours or in-flight rest, then need to perform safety-critical tasks soon after waking. This review analyzes literature related to sleep inertia and countermeasures applicable for aviation.METHODS: The large part of scientific literature that focuses on sleep inertia is based on studies in patients with chronic sleep inertia. We analyzed 8 narrative reviews and 64 papers related to acute sleep inertia in healthy subjects.DISCUSSION: Sleep inertia is a multifactorial, complex process, and many different protocols have been conducted, with a low number of subjects, in noncontrolled laboratory designs, with questionnaires or cognitive tests that have not been replicated. Evidence suggests that waking after sleep loss, or from deeper stages of sleep, can exacerbate sleep inertia through complex interactions between awakening and sleep-promoting brain structures. Nevertheless, no meta-analyses are possible and extrapolation to pilots' performances is hypothetical. Studies in real life or simulated operational situations must be conducted to improve the description of the impact of sleep inertia and kinetics on pilots' performances. Taking rest or sleep time remains the main method for pilots to fight against fatigue and related decreases in performance. We propose proactive strategies to mitigate sleep inertia and improve alertness.Sauvet F, Beauchamps V, Cabon P. Sleep inertia in aviation. Aerosp Med Hum Perform. 2024; 95(4):206-213.


Assuntos
Aviação , Sono , Humanos , Descanso , Encéfalo , Cognição
6.
BMJ ; 384: q513, 2024 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-38438195

RESUMO

The studyPavlova AV, Shim JSC, Moss R, et al. Effect of resistance exercise dose components for tendinopathy management: a systematic review with meta-analysis. Br J Sports Med 2023;57:1327-34.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/weights-resistance-bands-rest-days-best-tendinopathy/.


Assuntos
Terapia por Exercício , Doenças Musculoesqueléticas , Tendinopatia , Humanos , Doenças Musculoesqueléticas/terapia , Registros , Tendinopatia/terapia , Treinamento de Força , Descanso
7.
J Strength Cond Res ; 38(3): e116-e124, 2024 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-38416451

RESUMO

ABSTRACT: Winwood, PW, Keogh, JW, Travis, SK, Grieve, I, and Pritchard, HJ. The training and tapering practices of Highland Games heavy event athletes. J Strength Cond Res 38(3): e116-e124, 2024-This study provides the first empirical evidence of how Highland Games heavy event athletes train and taper for Highland Games competitions. Athletes (n = 169) (mean ± SD: age 40.8 ± 10.7 years, height 181.2 ± 9.5 cm, weight 107.2 ± 23.0 kg, 18.8 ± 10.3 years of general resistance training, and 8.1 ± 6.9 years of competitive Highland Games experience) completed a self-reported 4-page online survey on training and tapering practices. Analysis by sex (male and female) and competitive standard (local or regional, national, and international) was conducted. Seventy-eight percent (n = 132) of athletes reported that they used a taper. Athletes stated that their taper length was 5.2 ± 3.5 days, with the step (36%) and linear tapers (33%) being the most performed. Athletes reported that their highest training volume and intensity were 5.5 and 3.8 weeks out (respectively) from competition, and all training ceased 2.4 ± 1.4 days before competition. Training volume decreased during the taper by 34%. Athletes typically stated that, tapering was performed to achieve recovery, peak performance, and injury prevention; training intensity, frequency, and duration stayed the same or decreased; game-specific training increased with reductions in traditional exercises; the caber toss, weight for height, and heavy weight throw were performed further out from competition than other events; muscular power and strength were the most common types of training performed; static stretching, foam rolling, and massage were strategies used in the taper; and poor tapering occurred because of life/work circumstances, lack of sleep/rest, or training too heavy/hard. These results may aid Highland Games athletes to optimize training and tapering variables leading to improved performances.


Assuntos
Exercícios de Alongamento Muscular , Treinamento de Força , Humanos , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Atletas , Massagem , Descanso
8.
PLoS One ; 19(2): e0299311, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38408047

RESUMO

The aim of this study was to compare the effects of rest redistribution (RR) on kinetics and kinematics during the hang pull (HP). Twenty-one male athletes (age 29.5 ± 4.3 years, height 1.78 ± 0.07 m, body mass 75.17 ± 11.11 kg, relative one repetition maximum [1RM] power clean [PC] 1.17 ± 0.14 kg.kg-1) performed the HP using 140% of 1RM PC with 3 traditional sets of 6 repetitions (TS), 9 sets of 2 repetitions with RR [45s rest after 2 repetitions] (RR45) and 6 sets of 3 repetitions with RR [72s rest after 3 repetitions] (RR72). Peak velocity (PV) was higher during RR72 (1.18 ± 0.11 m.s-1) compared to RR45 (1.14 ± 0.11 m.s-1) for the average of 18 repetitions (p = 0.025, g = 0.36). There was a main effect for set configuration with greater peak force (PF) (p < 0.001, g = 0.14) during RR72 compared to RR45, with greater PV and impulse (p < 0.001, g = 0.19-0.36) during RR72 compared to RR45. There was also greater peak velocity maintenance (PVM) (p = 0.042, g = 0.44) for RR72 compared to RR45. There were no significant or meaningful differences (p > 0.05, g = 0.00-0.59) between configurations for any other variables. Rest redistribution protocols did not result in significantly or meaningfully greater kinetics or kinematics during the HP when compared to a TS protocol; although performing RR72 resulted in higher PF, PV, and impulse, with improved PVM compared to RR45.


Assuntos
Treinamento de Força , Humanos , Masculino , Adulto , Fenômenos Biomecânicos , Treinamento de Força/métodos , Levantamento de Peso , Cinética , Descanso , Força Muscular , Músculo Esquelético
9.
Brain Imaging Behav ; 18(2): 1-14, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38324235

RESUMO

Aberrant intrinsic brain networks are consistently observed in individuals with autism spectrum disorder. However, studies examining the strength of functional connectivity across brain regions have yielded conflicting results. Therefore, this study aimed to investigate the functional connectivity of the resting brain in children with low-functioning autism, including during the early developmental stages. We explored the functional connectivity of 43 children with autism spectrum disorder and 54 children with typical development aged 2 to 12 years using resting-state functional magnetic resonance imaging data. We used independent component analysis to classify the brain regions into six intrinsic networks and analyzed the functional connectivity within each network. Moreover, we analyzed the relationship between functional connectivity and clinical scores. In children with autism, the under-connectivities were observed within several brain networks, including the cognitive control, default mode, visual, and somatomotor networks. In contrast, we found over-connectivities between the subcortical, visual, and somatomotor networks in children with autism compared with children with typical development. Moderate effect sizes were observed in entire networks (Cohen's d = 0.43-0.77). These network alterations were significantly correlated with clinical scores such as the communication sub-score (r = - 0.442, p = 0.045) and the calibrated severity score (r = - 0.435, p = 0.049) of the Autism Diagnostic Observation Schedule. These opposing results observed based on the brain areas suggest that aberrant neurodevelopment proceeds in various ways depending on the functional brain regions in individuals with autism spectrum disorder.


Assuntos
Transtorno do Espectro Autista , Transtorno Autístico , Criança , Humanos , Imageamento por Ressonância Magnética , Encéfalo , Descanso
10.
Neurosci Lett ; 825: 137685, 2024 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-38367797

RESUMO

First-person shooting (FPS) games are among the most famous video games worldwide. However, cortical activities in environments related to real FPS games have not been studied. This study aimed to determine differences in cortical activity between low- and high-skilled FPS game players using 160-channel electroencephalography. Nine high-skilled FPS game players (official ranks: above the top 10%) and eight low-skilled FPS game players (official ranks: lower than the top 20%) were recruited for the experiment. The task was set for five different conditions using the AimLab program, which was used for the FPS game players' training. Additionally, we recorded the brain activity in the resting condition before and after the task, in which the participants closed their eyes and relaxed. The reaction time and accuracy (the number of hit-and-miss targets) were calculated to evaluate the task performance. The results showed that high-skilled FPS game players have fast reaction times and high accuracy during tasks. High-skilled FPS game players had higher cortical activity in the frontal cortex than low-skilled FPS game players during each task. In low-skilled players, cortical activity level and performance level were associated. These results suggest that high cortical activity levels were critical to achieving high performance in FPS games.


Assuntos
Jogos de Vídeo , Humanos , Lobo Frontal , Descanso , Análise Espectral , Eletroencefalografia
11.
Brain Topogr ; 37(2): 169-180, 2024 03.
Artigo em Inglês | MEDLINE | ID: mdl-38349451

RESUMO

The analysis of EEG microstates for investigating rapid whole-brain network dynamics during rest and tasks has become a standard practice in the EEG research community, leading to a substantial increase in publications across various affective, cognitive, social and clinical neuroscience domains. Recognizing the growing significance of this analytical method, the authors aim to provide the microstate research community with a comprehensive discussion on methodological standards, unresolved questions, and the functional relevance of EEG microstates. In August 2022, a conference was hosted in Bern, Switzerland, which brought together many researchers from 19 countries. During the conference, researchers gave scientific presentations and engaged in roundtable discussions aiming at establishing steps toward standardizing EEG microstate analysis methods. Encouraged by the conference's success, a special issue was launched in Brain Topography to compile the current state-of-the-art in EEG microstate research, encompassing methodological advancements, experimental findings, and clinical applications. The call for submissions for the special issue garnered 48 contributions from researchers worldwide, spanning reviews, meta-analyses, tutorials, and experimental studies. Following a rigorous peer-review process, 33 papers were accepted whose findings we will comprehensively discuss in this Editorial.


Assuntos
Mapeamento Encefálico , Encéfalo , Humanos , Mapeamento Encefálico/métodos , Eletroencefalografia/métodos , Descanso
12.
Hum Brain Mapp ; 45(2): e26587, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38339903

RESUMO

Recent years have seen growing interest in characterizing the properties of regional brain dynamics and their relationship to other features of brain structure and function. In particular, multiple studies have observed regional differences in the "timescale" over which activity fluctuates during periods of quiet rest. In the cerebral cortex, these timescales have been associated with both local circuit properties as well as patterns of inter-regional connectivity, including the extent to which each region exhibits widespread connectivity to other brain areas. In the current study, we build on prior observations of an association between connectivity and dynamics in the cerebral cortex by investigating the relationship between BOLD fMRI timescales and the modular organization of structural and functional brain networks. We characterize network community structure across multiple scales and find that longer timescales are associated with greater within-community functional connectivity and diverse structural connectivity. We also replicate prior observations of a positive correlation between timescales and structural connectivity degree. Finally, we find evidence for preferential functional connectivity between cortical areas with similar timescales. We replicate these findings in an independent dataset. These results contribute to our understanding of functional brain organization and structure-function relationships in the human brain, and support the notion that regional differences in cortical dynamics may in part reflect the topological role of each region within macroscale brain networks.


Assuntos
Encéfalo , Córtex Cerebral , Humanos , Encéfalo/diagnóstico por imagem , Córtex Cerebral/diagnóstico por imagem , Mapeamento Encefálico/métodos , Imageamento por Ressonância Magnética , Descanso , Rede Nervosa/diagnóstico por imagem
13.
PLoS One ; 19(2): e0298031, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38363743

RESUMO

OBJECTIVE: This study aims to test the association of rest-activity rhythm (intradaily variability and interdaily stability) with all-cause mortality in an older adult cohort in Brazil. It also assesses whether the amount of time spent at each intensity level (i.e., physical activity and nocturnal sleep) interferes with this association. METHODS: This cohort study started in 2014 with older adults (≥60 years). We investigated deaths from all causes that occurred until April 2017. Rest-activity rhythm variables were obtained using accelerometry at baseline. Intradaily variability indicates higher rhythm fragmentation, while interdaily stability indicates higher rhythm stability. Cox proportional-hazard models were used to test the associations controlling for confounders. RESULTS: Among the 1451 older adults interviewed in 2014, 965 presented valid accelerometry data. During the follow-up period, 80 individuals died. After adjusting the analysis for sociodemographic, smoking, morbidity score, and number of medicines, an increase of one standard deviation in interdaily stability decreased 26% the risk of death. The adjustment for total sleep time and inactivity did not change this association. On the other hand, the association was no longer significant after adjusting for overall physical activity and moderate to vigorous physical activity. CONCLUSION: Rest-activity rhythm pattern was not associated with mortality when physical activity was considered, possibly because this pattern could be driven by regular exercise. Promoting physical activity remains a relevant strategy to improve population health.


Assuntos
Ritmo Circadiano , Sono , Humanos , Idoso , Estudos de Coortes , Descanso , Exercício Físico
14.
PLoS One ; 19(2): e0296827, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38346024

RESUMO

Prior research has identified a variety of task-dependent networks that form through inter-regional phase-locking of oscillatory activity that are neural correlates of specific behaviors. Despite ample knowledge of task-specific functional networks, general rules governing global phase relations have not been investigated. To discover such general rules, we focused on phase modularity, measured as the degree to which global phase relations in EEG comprised distinct synchronized clusters interacting with one another at large phase lags. Synchronized clusters were detected with a standard community-detection algorithm, and the degree of phase modularity was quantified by the index q. Notably, we found that the mechanism controlling phase modularity is remarkably simple. A network comprising anterior-posterior long-distance connectivity coherently shifted phase relations from low-angles (|Δθ| < π/4) in low-modularity states (bottom 5% in q) to high-angles (|Δθ| > 3π/4) in high-modularity states (top 5% in q), accounting for fluctuations in phase modularity. This anterior-posterior network may play a fundamental functional role as (1) it controls phase modularity across a broad range of frequencies (3-50 Hz examined) in different behavioral conditions (resting with the eyes closed or watching a silent nature video) and (2) neural interactions (measured as power correlations) in beta-to-gamma bands were consistently elevated in high-modularity states. These results may motivate future investigations into the functional roles of phase modularity as well as the anterior-posterior network that controls it.


Assuntos
Algoritmos , Transtornos Mentais , Humanos , Olho , Descanso , Encéfalo
15.
Psychiatry Res ; 334: 115794, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38367454

RESUMO

Attention deficit hyperactivity disorder (ADHD) has been characterized by impairments among distributed functional brain networks, e.g., the frontoparietal network (FPN), default mode network (DMN), reward and motivation-related circuits (RMN), and salience network (SAL). In the current study, we evaluated the complexity and functional connectivity (FC) of resting state fMRI (rsfMRI) in pre-adolescents with the behavioral symptoms of ADHD, for pathology-relevant networks. We leveraged data from the Adolescent Brain and Cognitive Development (ABCD) Study. The final study sample included 63 children demonstrating the behavioral features of ADHD and 92 healthy control children matched on age, sex, and pubertal development status. For selected regions in the relevant networks, ANCOVA compared multiscale entropy (MSE) and FC between the groups. Finally, differences in the association between MSE and FC were evaluated. We found significantly reduced MSE along with increased FC within the FPN of pre-adolescents demonstrating the behavior symptoms of ADHD compared to matched healthy controls. Significant partial correlations between MSE and FC emerged in the FPN and RMN in the healthy controls however the association was absent in the participants demonstrating the behavior symptoms of ADHD. The current findings of complexity and FC in ADHD pathology support hypotheses of altered function of inhibitory control networks in ADHD.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Mapeamento Encefálico , Criança , Humanos , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico por imagem , Imageamento por Ressonância Magnética , Vias Neurais/diagnóstico por imagem , Descanso , Encéfalo , Sintomas Comportamentais , Análise de Sistemas
16.
Neurobiol Aging ; 137: 19-37, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38402780

RESUMO

Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the posterior rsEEG alpha eLORETA source activities from the eyes-closed to eyes-open condition at ≥ -10% and -10%, respectively. 75% of the ADMCI patients were REACTIVE. Compared to the UNREACTIVE group, the REACTIVE group showed (1) less abnormal posterior rsEEG source activity during the eyes-closed condition and (2) a decrease in that activity at the 6-month follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. Such a biomarker might reflect abnormalities in cortical arousal in quiet wakefulness to be used for clinical studies in ADMCI patients using 6-month follow-ups.


Assuntos
Doença de Alzheimer , Disfunção Cognitiva , Humanos , Ritmo alfa , Doença de Alzheimer/diagnóstico por imagem , Doença de Alzheimer/psicologia , Seguimentos , Descanso , Eletroencefalografia/métodos , Disfunção Cognitiva/diagnóstico , Biomarcadores , Córtex Cerebral
18.
Int Endod J ; 57(3): 344-354, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38204205

RESUMO

AIM: Cyst formation of the jaws is frequently accompanied by the proliferation of odontogenic epithelial cells located in the periodontal ligament (PDL), which consists of heterozygous cells and includes the most fibroblasts. The lining epithelium of radicular cyst, an odontogenic cyst of inflammatory origin, is derived from the proliferation of the remnants of the Hertwig epithelial root sheath (odontogenic epithelial cell rests of Malassez; ERMs) in the PDL. ERMs are maintained at a lower proliferative state under physiological conditions, but the regulatory mechanisms underlying the inflammation-dependent enhanced-proliferative capabilities of ERMs are not fully understood. The aim of this study was to evaluate the effects of cytokine pathway association between TGF-ß signalling and IL-1ß signalling on the regulation of odontogenic epithelial cell proliferation using radicular cyst pathological specimens and odontogenic epithelial cell lines. METHODOLOGY: Immunofluorescence analyses were performed to clarify the expression levels of Smad2/3 and Ki-67 in ERMs of 8-week-old mouse molar specimens. In radicular cyst (n = 52) and dentigerous cysts (n = 6) specimens from human patients, the expression of p65 (a main subunit of NF-κB), Smad2/3 and Ki-67 were investigated using immunohistochemical analyses. Odontogenic epithelial cells and PDL fibroblastic cells were co-cultured with or without an inhibitor or siRNAs. Odontogenic epithelial cells were cultured with or without TGF-ß1 and IL-1ß. The proliferative capabilities and Smad2 phosphorylation levels of odontogenic epithelial cells were examined. RESULTS: Immunohistochemically, Smad2/3-positivity was increased, and p65-positivity and Ki-67-positivity were decreased both in ERMs and in the epithelial cells in dentigerous cysts, a non-inflammatory developmental cyst. In contrast, p65-positive cells, along with the expression of Ki-67, were increased and Smad2/3-positive cells were decreased in the lining epithelia of radicular cysts. Co-culture experiments with odontogenic epithelial cells and PDL fibroblastic cells revealed that PDL cells-derived TGF-ß1/2 and their downstream signalling suppressed odontogenic epithelial cell proliferation. Moreover, TGF-ß1 stimulation induced Smad2 phosphorylation and suppressed odontogenic epithelial cell proliferation, while IL-1ß stimulation reversed these phenotypes through p65 transactivation. CONCLUSIONS: These results suggest that IL-1ß-p65 signalling promotes odontogenic epithelial cell proliferation through suppressing TGF-ß-Smad2 signalling, which would be involved in the pathogenesis of radicular cysts.


Assuntos
Cisto Dentígero , Cistos Odontogênicos , Cisto Radicular , Humanos , Animais , Camundongos , Cisto Radicular/patologia , Fator de Crescimento Transformador beta1 , Cisto Dentígero/complicações , Cisto Dentígero/metabolismo , Cisto Dentígero/patologia , Antígeno Ki-67 , Descanso , Cistos Odontogênicos/patologia , Células Epiteliais , Epitélio/patologia , Proliferação de Células , Fator de Crescimento Transformador beta/metabolismo , Interleucina-1beta
19.
Alzheimers Dement ; 20(3): 1966-1977, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38183333

RESUMO

INTRODUCTION: Sleep and rest-activity rhythm alterations are common in neurodegenerative diseases. However, their characterization in patients with behavioral variant frontotemporal dementia (bvFTD) has proven elusive. We investigated rest-activity rhythm alterations, sleep disturbances, and their neural correlates in bvFTD. METHODS: Twenty-seven bvFTD patients and 25 healthy controls completed sleep questionnaires and underwent 7 days of actigraphy while concurrently maintaining a sleep diary. Cortical complexity and thickness were calculated from T1-weighted magnetic resonance (MR) images. RESULTS: Compared to controls, bvFTD patients showed longer time in bed (95% confidence interval [CI]: 79.31, 321.83) and total sleep time (95% CI: 24.38, 321.88), lower sleep efficiency (95% CI: -12.58, -95.54), and rest-activity rhythm alterations in the morning and early afternoon. Increased sleep duration was associated with reduced cortical thickness in frontal regions. DISCUSSION: Patients with bvFTD showed longer sleep duration, lower sleep quality, and rest-activity rhythm alterations. Actigraphy could serve as a cost-effective and accessible tool for ecologically monitoring changes in sleep duration in bvFTD patients. HIGHLIGHTS: We assessed sleep and circadian rhythms in behavioral variant frontotemporal dementia (bvFTD) using actigraphy. Patients with bvFTD show increased sleep duration and reduced sleep quality. Patients with bvFTD show rest-activity alterations in the morning and early afternoon. Sleep duration is associated with reduced cortical thickness in frontal regions. These alterations may represent an early sign of neurodegeneration.


Assuntos
Demência Frontotemporal , Humanos , Demência Frontotemporal/diagnóstico por imagem , Sono , Ritmo Circadiano , Imageamento por Ressonância Magnética/métodos , Descanso
20.
J Exp Biol ; 227(4)2024 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-38235553

RESUMO

High-intensity interval training has attracted considerable attention as a time-efficient strategy for inducing physiological adaptations, but the underlying mechanisms have yet to be elucidated. By using metabolomics techniques, we investigated changes in the metabolic network responses in Thoroughbred horses to high-intensity interval exercise performed with two distinct (15 min or 2 min) rest intervals. The peak plasma lactate level was higher during high-intensity exercise with a 2 min rest duration than that with a 15 min rest duration (24.5±6.8 versus 13.3±2.7 mmol l-1). The arterial oxygen saturation was lower at the end of all exercise sessions with a 2 min rest duration than that with a 15 min rest duration. Metabolomic analysis of skeletal muscle revealed marked changes in metabolite concentrations in the first and third bouts of the 15 min rest interval conditions. In contrast, there were no metabolite concentrations or pathways that significantly changed during the third bout of exercise performed with a 2 min rest interval. Our findings suggest that the activity of each energy production system is not necessarily reflected by apparent changes in metabolite concentrations, potentially due in part to a better match between metabolite flux into and out of the pathway and cycle, as well as between metabolite production and disposal. This study provides evidence that changes in metabolite concentrations vary greatly depending on the number of repetitions and the length of rest periods between exercises, even if the exercises themselves are identical.


Assuntos
Músculo Esquelético , Condicionamento Físico Animal , Humanos , Animais , Cavalos , Músculo Esquelético/fisiologia , Terapia por Exercício , Consumo de Oxigênio/fisiologia , Descanso
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