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1.
Sensors (Basel) ; 24(4)2024 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-38400204

RESUMO

Postural control characteristics have been proposed as a predictor of Motion Sickness (MS). However, postural adaptation to sensory environment changes may also be critical for MS susceptibility. In order to address this issue, a postural paradigm was used where accurate orientation information from body sensors could be lost and restored, allowing us to infer sensory re-weighting dynamics from postural oscillation spectra in relation to car-sickness susceptibility. Seventy-one participants were standing on a platform (eyes closed) alternating from static phases (proprioceptive and vestibular sensors providing reliable orientation cues) to sway referenced to the ankle-angle phases (proprioceptive sensors providing unreliable orientation cues). The power spectrum density (PSD) on a 10 s sliding window was computed from the antero-posterior displacement of the center of pressure. Energy ratios (ERs) between the high (0.7-1.3 Hz) and low (0.1-0.7 Hz) frequency bands of these PSDs were computed on key time windows. Results showed no difference between MS and non-MS participants following loss of relevant ankle proprioception. However, the reintroduction of reliable ankle signals led, for the non-MS participants, to an increase of the ER originating from a previously up-weighted vestibular information during the sway-referenced situation. This suggests inter-individual differences in re-weighting dynamics in relation to car-sickness susceptibility.


Assuntos
Automóveis , Enjoo devido ao Movimento , Humanos , Postura , Propriocepção , Equilíbrio Postural
2.
Appl Ergon ; 117: 104238, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38316071

RESUMO

The purpose of this paper is to establish an easy-to-use questionnaire for subjective evaluations of visually induced motion sickness (VIMS) and visual fatigue caused by stereoscopic 3D (s3D) images. We reviewed previously used questionnaires and extracted 51 important subjective evaluation items from them. We then recruited 251 participants to observe 3D images designed to easily induce sickness or visual fatigue, and we asked them to respond to the 51 items. As a result of exploratory factor analysis, four factors were extracted according to their factor loadings, and the number of items was reduced to 21. Further processing by confirmatory factor analysis led to the selection of 15 items. Comparing mean ratings for each factor before and after item reduction indicated that item reduction did not significantly affect the participant responses. Therefore, the 15-item Visually Induced Symptoms Questionnaire (VISQ), can be used to evaluate VIMS and s3D visual fatigue.


Assuntos
Astenopia , Enjoo devido ao Movimento , Humanos , Astenopia/etiologia , Imageamento Tridimensional , Enjoo devido ao Movimento/etiologia , Inquéritos e Questionários
3.
BMC Med Educ ; 24(1): 156, 2024 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-38374042

RESUMO

BACKGROUND: The objective of this study was to investigate the impact of a rehabilitation program aimed at addressing vestibular and proprioceptive deficits, which are believed to underlie the pathophysiology of motion sickness. METHODS: A total of 121 medical students with motion sickness participated in this study and were randomly divided into intervention (n = 60) and placebo control (n = 61) groups. The intervention group underwent combined balance, proprioception, and vestibular training three times a week for 4 weeks, while the control group received placebo training. The study assessed various measurements, including the Virtual reality sickness questionnaire (VRSQ), tolerance duration, enjoyment level measured by VAS, stability levels using Biodex, and balance with the Flamingo balance test (FBT). All measurements were conducted both at baseline and 4 weeks later. RESULTS: There was no significant difference in pre-test scores between the intervention and control groups, suggesting a similar baseline in both groups (p > 0.05). The results showed a significant improvement in VRSQ, tolerance duration, VAS, Biodex, and FBT scores in the intervention group (p < 0.05). While, the control group showed a significant increase only in VAS scores after 4 weeks of training (p < 0.05). A statistically significant improvement was found between the groups for VRSQ (p < 0.001), tolerance duration (p < 0.001), VAS (p < 0.001), Biodex (p = 0.015), and FBT scores (p < 0.05), in favor of the intervention group. CONCLUSIONS: A combined balance training program for motion sickness proves to be effective in reducing motion sickness symptoms, enhancing user enjoyment, and extending the usage duration of virtual reality devices while improving balance and stability. In contrast, placebo training did not alter motion sickness levels. These findings offer valuable insights for expanding the usage of virtual reality, making it accessible to a broader population.


Assuntos
Enjoo devido ao Movimento , Realidade Virtual , Humanos , Terapia por Exercício/métodos , Enjoo devido ao Movimento/terapia , Enjoo devido ao Movimento/diagnóstico , Modalidades de Fisioterapia , Equilíbrio Postural/fisiologia , Método Duplo-Cego
4.
Fitoterapia ; 173: 105816, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38168571

RESUMO

Foeniculum vulgare Mill. is a medicinal and food homologous plant, and it has various biological activities. Yet, no research has explored its anti-motion sickness effects. Chemical properties of fennel extracts (FvE) and flavonoids (Fvf) were analyzed based on UPLC-QTRAP-MS to elucidate its potential anti-motion sickness components in the present study. The mice models of motion sickness were stimulated by biaxial rotational acceleration. Behavioral experiments such as motion sickness index and open field test and the measurement of neurotransmitters were used to evaluate the efficacy of compounds on motion sickness. Results showed that FvE contains terpenes, alkaloids, flavonoids, etc. Eight flavonoids including quercetin-3ß-D-glucoside, rutin, hyperoside, quercetin, miquelianin, trifolin, isorhamnetin and kaempferol were identified in the purified Fvf. FvE and Fvf significantly reduced the motion sickness index of mice by 53.2% and 48.9%, respectively. Fvf also significantly alleviated the anxious behavior of mice after rotational stimulation. Among the eight flavonoids, isorhamnetin had the highest oral bioavailability and moderate drug-likeness index and thus speculated to be the bioactive compound in fennel for its anti-motion sickness effect. It reduced the release of 5-HT and Ach to alleviate the motion sickness response and improve the work completing ability of mice and nervous system dysfunction after rotational stimulation. This study provided in-depth understanding of the anti-motion sickness bioactive chemical properties of fennel and its flavonoids, which will contribute to the new development and utilization of fennel.


Assuntos
Foeniculum , Enjoo devido ao Movimento , Flavonoides/farmacologia , Flavonoides/análise , Quercetina , Foeniculum/química , Cromatografia Líquida , Espectrometria de Massas em Tandem , Estrutura Molecular , Extratos Vegetais/química , Enjoo devido ao Movimento/tratamento farmacológico
5.
Exp Brain Res ; 242(3): 685-725, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38253934

RESUMO

Users of automated vehicles will engage in other activities and take their eyes off the road, making them prone to motion sickness. To resolve this, the current paper validates models predicting sickness in response to motion and visual conditions. We validate published models of vestibular and visual sensory integration that have been used for predicting motion sickness through sensory conflict. We use naturalistic driving data and laboratory motion (and vection) paradigms, such as sinusoidal translation and rotation at different frequencies, Earth-Vertical Axis Rotation, Off-Vertical Axis Rotation, Centrifugation, Somatogravic Illusion, and Pseudo-Coriolis, to evaluate different models for both motion perception and motion sickness. We investigate the effects of visual motion perception in terms of rotational velocity (visual flow) and verticality. According to our findings, the SVCI model, a 6DOF model based on the Subjective Vertical Conflict (SVC) theory, with visual rotational velocity input is effective at estimating motion sickness. However, it does not correctly replicate motion perception in paradigms such as roll-tilt perception during centrifuge, pitch perception during somatogravic illusion, and pitch perception during pseudo-Coriolis motions. On the other hand, the Multi-Sensory Observer Model (MSOM) accurately models motion perception in all considered paradigms, but does not effectively capture the frequency sensitivity of motion sickness, and the effects of vision on sickness. For both models (SVCI and MSOM), the visual perception of rotational velocity strongly affects sickness and perception. Visual verticality perception does not (yet) contribute to sickness prediction, and contributes to perception prediction only for the somatogravic illusion. In conclusion, the SVCI model with visual rotation velocity feedback is the current preferred option to design vehicle control algorithms for motion sickness reduction, while the MSOM best predicts perception. A unified model that jointly captures perception and motion sickness remains to be developed.


Assuntos
Ilusões , Percepção de Movimento , Enjoo devido ao Movimento , Humanos , Percepção de Movimento/fisiologia , Percepção Espacial/fisiologia , Rotação
6.
Cephalalgia ; 44(1): 3331024231223971, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38215227

RESUMO

BACKGROUND: Migraine and vestibular migraine are disorders associated with a heightened motion sensitivity that provoke symptoms of motion-induced nausea and motion sickness. VM affects ∼3% of adults in the USA and affects three-fold more women than men. Triptans (selective serotonin receptor agonists) relieve migraine pain but lack efficacy for vertigo. Murine models of photophobia and allodynia have used injections of calcitonin gene-related peptide (CGRP) or other migraine triggers, such as sodium nitroprusside (SNP), to induce migraine sensitivities in mice to touch and light. Yet, there is limited research on whether these triggers affect motion-induced nausea in mice, and whether migraine blockers can reduce these migraine symptoms. We hypothesized that systemic delivery of CGRP or SNP will increase motion sickness susceptibility and motion-induced nausea in mouse models, and that migraine blockers can block these changes induced by systemically delivered CGRP or SNP. METHODS: We investigated two measures of motion sickness assessment [motion sickness index (MSI) scoring and motion-induced thermoregulation] after intraperitoneal injections of either CGRP or SNP in C57BL/6J mice. The drugs olcegepant, sumatriptan and rizatriptan were used to assess the efficacy of migraine blockers. RESULTS: MSI measures were confounded by CGRP's effect on gastric distress. However, analysis of tail vasodilatations as a surrogate for motion-induced nausea was robust for both migraine triggers. Only olcegepant treatment rescued tail vasodilatations. CONCLUSIONS: These preclinical findings support the use of small molecule CGRP receptor antagonists for the treatment of motion-induced nausea of migraine, and show that triptan therapeutics are ineffective against motion-induced nausea of migraine.Trial Registration: Not Applicable.


Assuntos
Transtornos de Enxaqueca , Enjoo devido ao Movimento , Humanos , Masculino , Adulto , Feminino , Camundongos , Animais , Receptores de Peptídeo Relacionado com o Gene de Calcitonina/uso terapêutico , Peptídeo Relacionado com Gene de Calcitonina , Camundongos Endogâmicos C57BL , Transtornos de Enxaqueca/tratamento farmacológico , Transtornos de Enxaqueca/complicações , Enjoo devido ao Movimento/tratamento farmacológico , Enjoo devido ao Movimento/complicações , Náusea
7.
Int J Geriatr Psychiatry ; 39(1): e6060, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38241061

RESUMO

OBJECTIVES: Virtual Reality-based interventions have become an important element of digital mental health, offering accessible and scalable treatment options. However, studies on VR-based approaches in elderly patients are scarce. This explorative study examined the feasibility of using Virtual Reality (VR) for elderly patients with psychiatric illness, focusing on the sense of presence as the primary outcome. METHODS: The study included N = 30 patients between the ages of 59-92 years who were currently in geriatric psychiatric inpatient and day clinic treatment. Participants were assessed before, during and after a relaxing ten-minute VR experience. Attitude towards digital media and VR, subjective digital competence, and previous experience were examined using questionnaires. Motion sickness was measured repeatedly during the VR experience using the Fast Motion Sickness Scale (FMS). Patients rated their motion sickness and their general well-being in the virtual environment. Sense of presence in the virtual environment was quantified with the Igroup Presence Questionnaire (IPQ). RESULTS: Participants reported a notable sense of presence (M = 0.41 ± 1.4) in the virtual environment, particularly in terms of spatial presence. Motion sickness was reported by a minority of patients. Three patients terminated the VR application before it was finished. The average well-being during the VR experience was reported as high (70/100). Sense of presence and motion sickness showed a significant negative correlation. Presence, motion sickness and well-being were not significantly correlated with age, nor did they differ significantly between groups. CONCLUSIONS: This study underscores the potential of VR-based experiences in the treatment of elderly psychiatric patients and highlights their willingness and ability to engage with VR technology. While the results are promising, future research should explore more interactive VR scenarios and assess their safety and feasibility in elderly populations.


Assuntos
Enjoo devido ao Movimento , Realidade Virtual , Humanos , Idoso , Psiquiatria Geriátrica , Estudos de Viabilidade , Internet , Enjoo devido ao Movimento/psicologia
8.
Exp Brain Res ; 242(2): 463-475, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38170233

RESUMO

Virtual reality (VR) technology has been widely adopted for several professional and recreational applications. Despite rapid innovation in hardware and software, one of the long prevailing issues for end users of VR is the experience of VR sickness. Females experience stronger VR sickness compared to males, and previous research has linked susceptibility to VR sickness to the menstrual cycle (Munafo et al., Exp Brain Res 235(3):889-901). Here we investigated the female versus male experience in VR sickness while playing an immersive VR game, comparing days of the menstrual cycle when hormones peak: day 15 (ovulation-peak estrogen) and day 22 (mid-luteal phase-peak progesterone). We found that immersion duration was greater in the second session than the first, and discomfort was lessened, suggesting a powerful adaptation with repeated exposure. Due to the estrogen levels changing along with the exposure, there was no clear independent impact of that; note, though, that there was a significant difference between self-report and physiological measures implying that GSR is potentially an unreliable measure of motion sickness. Although prior work found a delay over 2 days between session would not allow adaptation and habituation to reduce VR sickness susceptibility, we found that a week delay has potential success.


Assuntos
Enjoo devido ao Movimento , Realidade Virtual , Humanos , Masculino , Feminino , Caracteres Sexuais , Interface Usuário-Computador , Estrogênios
9.
J Surg Educ ; 81(1): 25-36, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38036388

RESUMO

OBJECTIVE: Immersive virtual reality (IVR) can be utilized to provide low cost and easily accessible simulation on all aspects of surgical education. In addition to technical skills training in surgery, IVR simulation has been utilized for nontechnical skills training in domains such as clinical decision-making and pre-operative planning. This systematic review examines the current literature on the effectiveness of IVR for nontechnical skill acquisition in surgical education. DESIGN: A literature search was performed using MEDLINE, EMBASE, and Web of Science for primary studies published between January 1, 1995 and February 9, 2022. Four reviewers screened titles, abstracts, full texts, extracted data, and analyzed included studies to answer 5 key questions: How is IVR being utilized in nontechnical skills surgical education? What is the methodological quality of studies? What technologies are being utilized? What metrics are reported? What are the findings of these studies? RESULTS: The literature search yielded 2340 citations, with 12 articles included for qualitative synthesis. Of included articles, 33% focused on clinical decision-making and 67% on anatomy/pre-operative planning. Motion sickness was a recorded metric in 25% of studies, with an aggregate incidence of 13% (11/87). An application score was reported in 33% and time to completion in 16.7%. A commercially developed application was utilized in 25%, while 75% employed a noncommercial application. The Oculus Rift was used in 41.7% of studies, HTC Vive in 25%, Samsung Gear in 16.7% of studies, Google Daydream in 8%, and 1 study did not report. The mean Medical Education Research Quality Instrument (MERSQI) score was 10.3 ± 2.3 (out of 18). In all studies researching clinical decision-making, participants preferred IVR to conventional teaching methods and in a nonrandomized control study it was found to be more effective. Averaged across all studies, mean scores were 4.33 for enjoyment, 4.16 for utility, 4.11 for usability, and 3.73 for immersion on a 5-point Likert scale. CONCLUSIONS: The IVR nontechnical skills applications for surgical education are designed for clinical decision-making or anatomy/pre-operative planning. These applications are primarily noncommercially produced and rely upon a diverse array of HMDs for content delivery, suggesting that development is primarily coming from within academia and still without clarity on optimal utilization of the technology. Excitingly, users find these applications to be immersive, enjoyable, usable, and of utility in learning. Although a few studies suggest that IVR is additive or superior to conventional teaching or imaging methods, the data is mixed and derived from studies with weak design. Motion sickness with IVR remains a complication of IVR use needing further study to determine the cause and means of mitigation.


Assuntos
Enjoo devido ao Movimento , Treinamento por Simulação , Realidade Virtual , Humanos , Competência Clínica , Simulação por Computador , Treinamento por Simulação/métodos
10.
Exp Brain Res ; 242(1): 267-274, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38015244

RESUMO

Human passive motion during boat, car or airplane travel may trigger motion sickness. Seasickness is the most provoking manifestation of motion sickness. It imposes major constraints on quality of life and human performance. Based on seasickness susceptibility the population is usually categorized into susceptible (S) and non-susceptible (NS). During repeated exposure some susceptible individuals undergo habituation and obtain symptoms relief, reflecting a third group of habituating (H) individuals. Recently, accumulative evidence suggests that the vestibular time constant (Tc) is associated with motion sickness susceptibility and attenuation of symptoms. These studies demonstrated that repeated passive motion stimuli lead to temporary short-term (days) changes in Tc, whereas sea sickness habituation process lasts 3 to 6 months. Therefore, the goal of the present study was to examine the behavior of Tc during the entire span of the seasickness habituation process between the H, S and NS groups to find an objective test for seasickness severity prediction. Tc of 30 subjects was prospectively evaluated pre, 3 and 6 months post exposure to sea environment using a computerized rotatory chair system protocol. Seasickness severity was evaluated by Wiker questionnaire. Significantly shorter Tc was found in the S group compared with the NS and H groups. Further analysis revealed lower maximal Slow Phase Velocity (mSPV) and nystagmus frequency (total number of beats/second) in the S group. Our results suggest that Tc, mSPV and nystagmus frequency might serve as a prediction for seasickness severity. This study was retrospectively registered on December 7th 2022 and assigned the identifier number NCT05640258.


Assuntos
Enjoo devido ao Movimento , Vestíbulo do Labirinto , Humanos , Estudos Prospectivos , Qualidade de Vida , Enjoo devido ao Movimento/etiologia , Suscetibilidade a Doenças
11.
Laryngoscope ; 134(1): 426-432, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37357969

RESUMO

OBJECTIVE: To explore the predictive factors between Meniere's disease (MD) and vestibular migraine (VM) by Gadolinium-enhanced Magnetic resonance imaging (MRI) of the inner ear and Clinical Features. METHODS: Eighty-seven patients (50 MD and 37 VM) underwent intratympanic injection of gadolinium and MRI was performed 24 h later. All patients underwent pure tone audiometry and caloric tests. RESULTS: In the MD group, 46 (92%) of 50 patients developed endolymphatic hydrops, although only 2 (5.4%) in the vestibular migraine (VM) group had positive results groups (p < 0.001). The incidence of migraine was 14% in the MD group and 67.7% in the VM group (p < 0.001). Multivariate logistic regression of the two groups of patients indicated that the greater the sum of the maximum slow phase velocity (SPV) of the ipsilateral ear, the higher the risk of VM occurrence (p = 0.009). The incidence of carsickness was positively correlated with the incidence of VM (p < 0.001) and asymmetric hearing loss (AHL) was negatively correlated with the diagnosis of VM (p = 0.045). CONCLUSION: Gadolinium-enhanced MRI of the inner ear is helpful for the differential diagnosis of VM and MD. Carsickness, decreased AHL, and increased Sum of the maximum SPV in the ipsilateral side (SSPVI) may act as diagnostic predictors of VM. LEVEL OF EVIDENCE: 3 Laryngoscope, 134:426-432, 2024.


Assuntos
Hidropisia Endolinfática , Perda Auditiva , Doença de Meniere , Transtornos de Enxaqueca , Enjoo devido ao Movimento , Humanos , Doença de Meniere/diagnóstico por imagem , Doença de Meniere/epidemiologia , Gadolínio , Vertigem , Hidropisia Endolinfática/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Transtornos de Enxaqueca/diagnóstico , Transtornos de Enxaqueca/epidemiologia
12.
Artigo em Inglês | MEDLINE | ID: mdl-38082862

RESUMO

Analysis of heart rate variability (HRV) can reveal a range of useful information regarding the dynamics of the autonomic nervous system (ANS). It is considered a robust and reliable tool to understand even some subtle changes in ANS activity. Here, we study the "hidden" characteristic changes in HRV during visually induced motion sickness; using nonlinear analytical methods, supplemented by conventional time- and frequency-domain analyses. We computed HRV from electrocardiograms (ECG) of 14 healthy participants measured at baseline and during nausea. Primarily hypothesizing evident differences in measures of physiologic complexity (SampEn; sample entropy, FuzzyEn; fuzzy entropy), chaos (LLE; largest Lyapunov exponent) and Poincaré/Lorenz (CSI; cardiac sympathetic activity, CVI; cardiac vagal index) between the two states. We found that during nausea, participants showed a markedly higher degree of regularity (SampEn, p = 0.0275; FuzzyEn, p = 0.0006), with a less chaotic ANS response (LLE, p = 0.0004). CSI significantly increased during nausea compared to baseline (p = 0.0005), whereas CVI did not appear to be statistically different between the two states (p = 0.182). Our findings suggest that motion sickness-induced ANS perturbations may be quantifiable via nonlinear HRV indices. These findings have implications for understanding the malaise of motion sickness and in turn, aid development of therapeutic interventions to relieve motion sickness symptoms.Clinical relevance- The study suggests potential indices of physiologic complexity and chaos that may be useful in monitoring motion sickness during clinical studies.


Assuntos
Eletrocardiografia , Enjoo devido ao Movimento , Humanos , Frequência Cardíaca/fisiologia , Sistema Nervoso Autônomo/fisiologia , Enjoo devido ao Movimento/etiologia , Náusea
13.
Acta Otolaryngol ; 143(10): 856-860, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-38071651

RESUMO

BACKGROUND: Vestibular Migraine (VM) is a frequent cause of recurrent spontaneous vertigo. While some report a normal Video Head Impulse Test (vHIT) in VM, others observed abnormal results on this test. Whether or not methodological discrepancies could be the cause of these differences is not known. There are 2 vHIT methods: subjects fixating an earth-fixed target (HIMP paradigm) or a head-fixed target, the suppression head impulse test (SHIMP paradigm). OBJECTIVES: The present study aimed to compare VM patients against healthy controls on both HIMP and SHIMP in order to unravel any differences between them. METHODS: Forty-eight VM patients and 27 healthy controls tested with both the HIMP and SHIMP paradigm. Results: Our 48 VM patients showed mean VOR normal range gains in both the HIMP and SHIMP paradigms, although there were some VOR impairments in individual semicircular SCCs. VM patients with motion sickness had lower horizontal VOR gain than those without motion sickness, with the HIMP, but not the SHIMP paradigm. CONCLUSION: VM patients have normal VOR gain with either vHIT paradigm. SIGNIFICANCE: The clinical significance of this observation is that a definitely abnormal vHIT with either method is unlikely to be due to vestibular migraine and an alternative diagnosis should be sought.


Assuntos
Transtornos de Enxaqueca , Enjoo devido ao Movimento , Humanos , Teste do Impulso da Cabeça/métodos , Reflexo Vestíbulo-Ocular , Vertigem/diagnóstico , Vertigem/etiologia , Tontura , Transtornos de Enxaqueca/diagnóstico , Canais Semicirculares
14.
Artigo em Inglês | MEDLINE | ID: mdl-38082614

RESUMO

The impact of visually induced motion sickness from virtual reality (VR) because of viewing patterns, view movements, and background global motion was investigated experimentally through classification into four categories.Each of the ten subjects underwent watching four patterns with bio-signal measurements, such as electrocardiogram and respiration, answering a subjective questionnaire.The results of the subjective evaluation of biological effects indicate that the VR viewing pattern has a significantly lower influence on visually induced motion sickness than other patterns, such as viewing with global background motion or sight motion by operating the controller.Clinical Relevance- This study aimed to reduce the effects of visually induced motion sickness in VR viewing, particularly to reduce the burden on the eyes and body.


Assuntos
Enjoo devido ao Movimento , Realidade Virtual , Humanos , Movimento (Física) , Enjoo devido ao Movimento/diagnóstico , Enjoo devido ao Movimento/etiologia , Movimento , Inquéritos e Questionários
15.
Artigo em Inglês | MEDLINE | ID: mdl-38083234

RESUMO

Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel neuromodulation application for vagal afferent stimulation. Owing to its non-invasive nature, taVNS is a potent therapeutic tool for a diverse array of diseases and disorders that ail us. Herein, we investigated taVNS-induced effects on neural activity of participants during visually induced motion sickness. 64-channel electroencephalography (EEG) recordings were obtained from 15 healthy participants in a randomized, within-subjects, cross-over design during sham and taVNS conditions. To assess motion sickness severity, we used the motion sickness assessment questionnaire (MSAQ). We observed that taVNS attenuated theta (4-8 Hz) brain activity in the right frontal, right parietal and occipital cortices when compared to sham condition. The total MSAQ scores, and central, peripheral and sopite MSAQ categorical scores were significantly lower after taVNS compared to sham. These findings reveal for the first time the potential therapeutic role of taVNS toward counter-motion sickness, and suggest that taVNS may be reliable in alleviating symptoms of motion sickness in real-time, non-pharmacologically.Clinical relevance- This suggests taVNS potential to offset motion sickness-induced nausea; which may be of translational value to counter e.g., chemotherapy-induced nausea.


Assuntos
Enjoo devido ao Movimento , Estimulação Elétrica Nervosa Transcutânea , Estimulação do Nervo Vago , Humanos , Enjoo devido ao Movimento/etiologia , Enjoo devido ao Movimento/terapia , Náusea , Projetos Piloto , Estudos Cross-Over
16.
Int J Med Mushrooms ; 25(12): 1-13, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37947060

RESUMO

Motion sickness (MS) is a disorder of the autonomic nervous system caused by abnormal exercise with symptoms such as nausea, vomiting and drowsiness. More than 90% of the human population has experienced different degrees of MS. At present, anticholinergics, antihistamines, and sympathomimetic drugs are used for treating MS, but these drugs generally have some adverse reactions and are not suitable for all people. Therefore, it is necessary to develop anti-MS drugs that have high efficiency and no adverse effects. Previous studies have found that Chroogomphus rutilus polysaccharide (CRP) is effective at preventing and treating MS in rats and mice. However, its mechanism of action is not clear. To clarify whether the CRP has anti-MS effects in mice, and to clarify its mechanism, we performed behavioral, biochemical, and morphological tests in a Kunming mouse model. Our results indicate that CRPs can significantly relieve the symptoms of MS, and their effect is equivalent to that of scopolamine, a commonly used anti-MS medicine. Our results indicate that CRPs may directly act on the gastrointestinal chromaffin cells to inhibit the synthesis and release of serotonin (5-hydroxytryptamine, or 5-HT) and thus reduce the signal from the gastrointestinal tract.


Assuntos
Agaricales , Enjoo devido ao Movimento , Humanos , Camundongos , Ratos , Animais , Serotonina/uso terapêutico , Enjoo devido ao Movimento/tratamento farmacológico , Enjoo devido ao Movimento/prevenção & controle , Polissacarídeos/farmacologia
17.
Multisens Res ; 36(8): 827-864, 2023 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-37907066

RESUMO

Vection is typically defined as the embodied illusion of self-motion in the absence of real physical movement through space. Vection can occur in real-life situations (e.g., 'train illusion') and in virtual environments and simulators. The vast majority of vection research focuses on vection caused by visual stimulation. Even though visually induced vection is arguably the most compelling type of vection, the role of nonvisual sensory inputs, such as auditory, biomechanical, tactile, and vestibular cues, have recently gained more attention. Non-visual cues can play an important role in inducing vection in two ways. First, nonvisual cues can affect the occurrence and strength of vection when added to corresponding visual information. Second, nonvisual cues can also elicit vection in the absence of visual information, for instance when observers are blindfolded or tested in darkness. The present paper provides a narrative review of the literature on multimodal contributions to vection. We will discuss both the theoretical and applied relevance of multisensory processing as related to the experience of vection and provide design considerations on how to enhance vection in various contexts.


Assuntos
Ilusões , Percepção de Movimento , Enjoo devido ao Movimento , Humanos , Ilusões/fisiologia , Percepção de Movimento/fisiologia , Sensação , Movimento (Física)
18.
Proc Natl Acad Sci U S A ; 120(44): e2304933120, 2023 10 31.
Artigo em Inglês | MEDLINE | ID: mdl-37847729

RESUMO

Travel can induce motion sickness (MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory information and past visual and motion memory, triggering a malaise accompanied by hypolocomotion, hypothermia, hypophagia, and nausea. Vestibular nuclei (VN) are critical for the processing of movement input from the inner ear. Motion-induced activation of VN neurons recapitulates MS-related signs. However, the genetic identity of VN neurons mediating MS-related autonomic and aversive responses remains unknown. Here, we identify a central role of cholecystokinin (CCK)-expressing VN neurons in motion-induced malaise. Moreover, we show that CCK VN inputs onto the parabrachial nucleus activate Calca-expressing neurons and are sufficient to establish avoidance to novel food, which is prevented by CCK-A receptor antagonism. These observations provide greater insight into the neurobiological regulation of MS by identifying the neural substrates of MS and providing potential targets for treatment.


Assuntos
Enjoo devido ao Movimento , Vestíbulo do Labirinto , Animais , Camundongos , Movimento , Neurônios/fisiologia , Núcleos Vestibulares/fisiologia , Vestíbulo do Labirinto/fisiologia
19.
Exp Brain Res ; 241(11-12): 2669-2682, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37796301

RESUMO

Entry motion sickness (EMS) affects crewmembers upon return to Earth following extended adaptation to microgravity. Anticholinergic pharmaceuticals (e.g., Meclizine) are often taken prior to landing; however, they have operationally adverse side effects (e.g., drowsiness). There is a need to develop non-pharmaceutical countermeasures to EMS. We assessed the efficacy of a technological countermeasure providing external visual cues following splashdown, where otherwise only nauseogenic internal cabin visual references are available. Our countermeasure provided motion-congruent visual cues of an Earth-fixed scene in virtual reality, which was compared to a control condition with a head-fixed fixation point in virtual reality in a between-subject design with 15 subjects in each group. We tested the countermeasure's effectiveness at mitigating motion sickness symptoms at the end of a ground-based reentry analog: approximately 1 h of 2Gx centrifugation followed by up to 1 h of wave-like motion. Secondarily, we explored differences in vestibular-mediated balance performance between the two conditions. While Motion Sickness Questionnaire outcomes did not differ detectably between groups, we found significantly better survival rates (with dropout dictated by reporting moderate nausea consecutively over 2 min) in the visual countermeasure group than the control group (79% survival vs. 33%, t(14) = 2.50, p = 0.027). Following the reentry analogs, subjects demonstrated significantly higher sway prior to recovery (p = 0.0004), which did not differ between control and countermeasure groups. These results imply that providing motion-congruent visual cues may be an effective mean for curbing the development of moderate nausea and increasing comfort following future space missions.


Assuntos
Enjoo devido ao Movimento , Voo Espacial , Realidade Virtual , Humanos , Astronautas , Enjoo devido ao Movimento em Voo Espacial/tratamento farmacológico , Náusea/etiologia
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