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1.
Medicentro (Villa Clara) ; 27(3)sept. 2023.
Artigo em Espanhol | LILACS | ID: biblio-1514481

RESUMO

Introducción: La enfermedad cerebrovascular (ECV) es una urgencia neurológica que en ocasiones se encuentra influenciada por los cambios del tiempo. La ECV isquémica es una emergencia médica con una ventana estrecha para su diagnóstico y tratamiento. El daño generado por esta enfermedad se estima mediante de la mortalidad, discapacidad e impacto social. Objetivo: Proponer un programa de capacitación basado en los efectos fisiopatológicos que provocan en los pacientes, cambios de tiempo y ritmo circadiano en el contexto de la adaptación al cambio climático. Método: Se desarrolló un estudio multietápico prospectivo en el Hospital Universitario Mártires del 9 de Abril del municipio Sagua la Grande entre los años 1993 a 2017. En la primera etapa se seleccionó un universo de 52 profesionales de la salud que atendieron a estos pacientes; en la segunda, 48 y en la tercera, 61. Resultados: El nivel de conocimiento del personal de salud en una primera etapa era inadecuado (78,85 %); en la tercera, este porcentaje disminuyó (14,75 %). Como resultado de la capacitación mejoraron los tiempos de atención a los pacientes con ECV a su llegada al hospital, y en la tercera, más del 50 % de los enfermos fueron atendidos antes de las seis horas de inicio de los síntomas. Conclusiones: La capacitación sobre ECV basada en los efectos fisiopatológicos que provocan en los pacientes el cambio climático y el ritmo circadiano disminuyó el tiempo de espera, y se asoció con una reducción de la morbilidad y la mortalidad, después de aplicar este programa.


Introduction: cerebrovascular disease (CVD) is a neurological emergency that is sometimes influenced by climate changes. Ischemic CVD is a medical emergency with a narrow window for diagnosis and treatment. The damage generated by this disease is estimated through mortality, disability and social impact. Objective: to propose a training program based on the pathophysiological effects in patients caused by changes in time and circadian rhythm in the context of adaptation to climate change. Methods: a multistage prospective study was conducted at "Mártires del 9 de Abril" University Hospital in Sagua la Grande municipality between 1993 and 2017. A universe of health professionals who cared for these patients was selected as follows: 52 in the first stage; 48 in the second stage, and 61 in the third ones. Results: the level of knowledge of health personnel in the first stage was inadequate (78.85%); this percentage decreased in the third stage (14.75%). Care times for CVD patients improved upon arrival at the hospital as a result of the training, as well as in the third ones, more than 50% of the patients were seen within six hours of the onset of symptoms. Conclusions: CVD training based on the pathophysiological effects of climate change and circadian rhythm on patients decreased waiting time, and was associated with reduced morbidity and mortality, after applying this program.


Assuntos
Mudança Climática , Morbidade , Mortalidade , Doença Cerebrovascular dos Gânglios da Base
3.
Pediatr Neurol ; 145: 22-27, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37257396

RESUMO

Mineralizing lenticulostriate vasculopathy is a well-recognized risk factor for basal ganglia stroke after minor head trauma in infants and young children; it is diagnosed on head computed tomography by the presence of basal ganglia calcification, seen as punctate hyperdensities on axial and linear hyperdensities on reconstructed coronal and sagittal images. In children with anterior fontanel window, its presence is suggested by branching hyperechogenic stripes in the basal ganglia region on cranial ultrasound. Brain magnetic resonance imaging, including susceptibility-weighted sequences and brain magnetic resonance angiography, fail to detect calcification or vascular abnormalities. Although its etiology remains unknown, mineralizing lenticulostriate vasculopathy is considered to represent end-stage pathology of lenticulostriate vasculopathy, a neonatal radiographic condition detected during routine neonatal cranial ultrasonographic examination and represents nonspecific finding associated with a multitude of etiologies. The significance of mineralizing lenticulostriate vasculopathy lies in the fact that it has emerged as one of the most common risk factors for basal ganglia stroke in Indian children, accounting for one-fourth to one-half of all causes of stroke in some studies. The outcome of stroke in children with mineralizing lenticulostriate vasculopathy appears to be favorable with the majority achieving complete or nearly complete recovery of their motor functions. Stroke recurrence following repeat head trauma is seen in a small proportion of children despite aspirin treatment.


Assuntos
Doença Cerebrovascular dos Gânglios da Base , Calcinose , Traumatismos Craniocerebrais , Acidente Vascular Cerebral , Lactente , Recém-Nascido , Criança , Humanos , Pré-Escolar , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/complicações , Traumatismos Craniocerebrais/complicações , Traumatismos Craniocerebrais/diagnóstico por imagem , Gânglios da Base/diagnóstico por imagem , Doença Cerebrovascular dos Gânglios da Base/complicações , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Calcinose/complicações , Fatores de Risco
4.
J Perinatol ; 43(5): 568-572, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-36376451

RESUMO

OBJECTIVE: Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV. STUDY DESIGN: We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups. RESULTS: We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01). CONCLUSION: The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.


Assuntos
Doença Cerebrovascular dos Gânglios da Base , Recém-Nascido Prematuro , Lactente , Recém-Nascido , Humanos , Feminino , Gravidez , Placenta , Estudos Retrospectivos , Idade Gestacional , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Doença Cerebrovascular dos Gânglios da Base/complicações
5.
Paediatr Int Child Health ; 42(2): 67-71, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35471857

RESUMO

Acute basal ganglia infarct following minor head trauma in association with mineralisation of lenticulostriate arteries is an increasingly recognised entity in childhood stroke. Three cases with a classical history and phenotypical features of mineralising angiopathy are described. Case 1 was a 2-year-old girl who presented with acute onset hemiparesis with a same-side upper motor neuron (UMN)-type facial palsy following minor head trauma. Case 2 was a 14-month-old boy who presented with a left side hemiparesis and a left UMN-type facial nerve palsy following a minor fall. Case 3 was an 8-month-old boy who, following a fall from his cot, had a sudden-onset hemiparesis on the right side and deviation of the angle of the mouth to the left. In brain computed tomography, all three cases demonstrated characteristic basal ganglia calcification of the mineralising angiopathy. Magnetic resonance imaging of the brain demonstrated features supportive of acute infarcts in the lentiform nucleus, caudate nucleus and putamen. Two of the patients had iron deficiency anaemia with haemoglobin of 7.0 g/dL and 7.8 g/dL, respectively. On follow-up, Case 1 had mild residual weakness and the other two made a complete recovery. None of the patients had a recurrence of stroke. Basal ganglia stroke with mineralising angiopathy should be considered in toddlers presenting with sudden-onset focal neurological deficits preceded by minor head trauma.Abbreviations: ADC: apparent diffusion coefficient; CT: computed tomography; DWI: diffusion-weighted imaging; Hb: haemoglobin; IDA: iron deficiency anaemia; MRI: magnetic resonance imaging; SLV: sonographic lenticulostriate vasculopathy; SWI: susceptibility weighted imaging; UMN: upper motor neuron.


Assuntos
Anemia , Doença Cerebrovascular dos Gânglios da Base , Traumatismos Craniocerebrais , Acidente Vascular Cerebral , Anemia/complicações , Doença Cerebrovascular dos Gânglios da Base/complicações , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Pré-Escolar , Traumatismos Craniocerebrais/complicações , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Paresia/etiologia , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/diagnóstico por imagem
6.
Med Glas (Zenica) ; 19(1): 1-5, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-35112561

RESUMO

Lenticulostriate vasculopathy (LSV) is a relatively common fi nding in routine cranial ultrasound examination that has been associated with many infectious and non-infectious conditions. The aim of this review was to provide a better understanding of LSV ultrasound fi nding, as well as the need for further laboratory and imaging examinations in infants. The most of the published studies represented small series, with few prospective long-term studies involving the control groups. Authors have mostly found an association between LSV, especially higher-grade (although there is no universally accepted classifi cation) with congenital cytomegalovirus (CMV) infection, classifying those children as at risk for sensorineural hearing loss. In contrast, some authors pointed out that LSV could be found relatively often, and believe that isolated LSV, especially lower-grade, is not predictive for an unfavourable outcome and a long-term prognosis. Therefore, although 35 years have passed since the first publication of LSV, there is still no consensus among experts on the clinical signifi cance of isolated LSV, but caution is certainly needed given the fact that most infants with congenital CMV are asymptomatic.


Assuntos
Doença Cerebrovascular dos Gânglios da Base , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Encéfalo , Criança , Ecoencefalografia , Humanos , Lactente , Estudos Prospectivos , Ultrassonografia
8.
J Stroke Cerebrovasc Dis ; 30(6): 105747, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33784520

RESUMO

OBJECTIVES: The present study aimed to examine the effectiveness of proton magnetic resonance spectroscopy (1HMRS) in determining the progression of neurological symptoms resulting in acute ischemic stroke in patients with lenticulostriate artery (LSA) infarction. MATERIALS AND METHODS: 1HMRS was performed within 72 h after neurological symptom onset. Voxel of interest was placed in tissue that included the pyramidal tract and identified diffusion weighted echo planar spin-echo sequence (DWI) coronal images. Infarct volume in DWI was calculated using the ABC/2 method. 1HMRS data (tNAA, tCr, Glx, tCho, and Ins) were analyzed using LCModel. Progressive neurological symptoms were defined as an increase of 1 or more in the NIHSS score. Patients who underwent 1HMRS after progressive neurological symptoms were excluded. RESULTS: In total, 77 patients were enrolled. Of these, 19 patients had progressive neurological symptoms. The patients with progressive neurological symptoms were significantly more likely to be female and had higher tCho/tCr values, higher rates of axial slices ≥ 3 slices on DWI, higher infarct volume on DWI, higher maximum diameter of infarction of axial slice on DWI, and higher SBP on admission compared to those without. Multivariable logistic analysis revealed that higher tCho/tCr values were independently associated with progressive neurological symptoms after adjusting for age, sex, and initial DWI infarct volume (tCho/tCr per 0.01 increase, OR 1.26, 95% CI 1.03-1.52, P = 0.022). CONCLUSIONS: Increased tCho/tCr score were associated with progressive neurological symptoms in patients with LSA ischemic stroke. Quantitative evaluation of 1HMRS parameters may be useful for predicting the progression of neurological symptoms.


Assuntos
Doença Cerebrovascular dos Gânglios da Base/diagnóstico , Biomarcadores/metabolismo , Infarto Encefálico/diagnóstico , Colina/metabolismo , Creatina/metabolismo , Espectroscopia de Prótons por Ressonância Magnética , Idoso , Idoso de 80 Anos ou mais , Doença Cerebrovascular dos Gânglios da Base/metabolismo , Doença Cerebrovascular dos Gânglios da Base/fisiopatologia , Infarto Encefálico/metabolismo , Infarto Encefálico/fisiopatologia , Imagem de Difusão por Ressonância Magnética , Avaliação da Deficiência , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes
9.
BMC Neurol ; 21(1): 84, 2021 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-33610173

RESUMO

BACKGROUND: Stroke in children easily causes long-term dysfunction. Whether the prognoses of motor and anxiety disorders are related to the affected stroke area has not been reported. METHODS: One hundred nine cases of children with ischaemic stroke were reviewed and divided into three groups: lenticular nucleus lesions only (lenticular nucleus group), lenticular nucleus and caudate head lesions (caudate head group), and lenticular nucleus and thalamus lesions (thalamus group). Overall prognosis was evaluated by the mRS score. The SCAS-P was used to evaluate anxiety in children aged ≥6 years. RESULTS: mRS scores were ≤ 2 points (mean: 0.62), no significant difference among groups. 3/21 (14.2%) patients in the caudate head group changed handedness, which is significantly higher than other groups. Patients with lesions in thalamus group had significantly higher SCAS-P scores. CONCLUSIONS: The overall prognosis of children with basal ganglia ischaemic stroke is good. However, hand preference changes and anxiety disorders may develop. Patients in the caudate head groups are more likely to suffer from fine motor disorders and changes in handedness. Patients within the thalamus group are more prone to anxiety than patients in the other groups. Anxiety disorders should be noted in children with basal ganglia stroke.


Assuntos
Transtornos de Ansiedade/fisiopatologia , Doença Cerebrovascular dos Gânglios da Base/fisiopatologia , Núcleo Caudado , Corpo Estriado , Lateralidade Funcional , AVC Isquêmico/fisiopatologia , Destreza Motora/fisiologia , Tálamo , Adolescente , Gânglios da Base , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Doença Cerebrovascular dos Gânglios da Base/psicologia , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , AVC Isquêmico/diagnóstico por imagem , AVC Isquêmico/psicologia , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Masculino , Estudos Retrospectivos , Acidente Vascular Cerebral/fisiopatologia , Tomografia Computadorizada por Raios X
10.
Brain Nerve ; 73(1): 89-93, 2021 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-33361516

RESUMO

Lenticulostriate artery (LSA) aneurysm is relatively rare, and the need for surgical intervention is controversial. Here, we report a case of ruptured LSA aneurysm which was accompanied by familial Mediterranean fever (FMF). A 45-year-old woman with a history of FMF presented with sudden onset of headache and vertigo. Computed tomography revealed hemorrhage in the right caudate nucleus and lateral ventricles. Digital subtraction angiography revealed a fusiform aneurysm (3mm) at the distal site of medial LSA. Observation was selected, and the aneurysm gradually decreased and eventually disappeared on the 105th day from the onset. This was the first report describing an LSA aneurysm associated with FMF. It suggests that such aneurysms could be treated conservatively with close radiological follow-up.


Assuntos
Aneurisma Roto , Doença Cerebrovascular dos Gânglios da Base , Febre Familiar do Mediterrâneo , Aneurisma Intracraniano , Hemorragia Subaracnóidea , Aneurisma Roto/complicações , Aneurisma Roto/diagnóstico por imagem , Aneurisma Roto/cirurgia , Angiografia Cerebral , Feminino , Humanos , Aneurisma Intracraniano/complicações , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/terapia , Hemorragias Intracranianas , Pessoa de Meia-Idade
11.
World Neurosurg ; 145: 471-479.e10, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32889194

RESUMO

BACKGROUND: Lenticulostriate artery aneurysms (LSAs) are rare vascular aberrations. Despite the potentially catastrophic sequelae of aneurysmal rupture, the optimal management strategy for LSA aneurysms has not been determined. The aim of the present review is to provide an overview of the clinical presentation and treatment strategies for LSA aneurysms. METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a literature search was conducted in the PubMed, Cochrane, EBSCOhost, Scopus, Web of Science, and ProQuest search engines to identify reported studies of LSA aneurysms until July 1, 2020. A descriptive analysis was performed. RESULTS: A total of 71 studies with 112 cases of LSA aneurysms were included. Patient age ranged from 2 months to 83 years (median, 44.5 years). Male and female patients were affected similarly (49% and 51%, respectively). The most common presentation was aneurysmal rupture (78%), and headache was the most frequently reported symptom (36%). Overall, 48% of the patients had undergone underwent surgical treatment, 30% conservative management, 21% endovascular treatment, and 1% radiosurgery. Four patients died, all of whom had presented with aneurysmal rupture. CONCLUSION: We have summarized the reported cases of LSA aneurysms, with their clinical presentation, management, and outcomes, for physicians who may be confronted with this diagnosis. Future studies that use available classification systems and include as much detail as possible should be encouraged to fully elucidate the optimal management strategy for these patients.


Assuntos
Doença Cerebrovascular dos Gânglios da Base , Aneurisma Intracraniano , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Adulto Jovem
12.
J Med Invest ; 67(3.4): 372-374, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33148920

RESUMO

Optimal treatment of patients with intracranial subocclusive thrombus remains unclear. Such a rare case successfully managed with endovascular mechanical thrombectomy is presented. A 71-year-old man experienced a sudden onset of dysarthria and motor deficits. At the time of admission his National Institutes of Health Stroke Scale (NIHSS) score was 4. DWI demonstrated incomplete infarction within the left lenticulostriate artery (LSA) territory, MRA showed partial flow defect in the distal left M1 segment and non-visualization of the LSA, and ECG revealed atrial fibrillation, thus ischemic stroke caused by cardiogenic embolism was diagnosed. Tissue plasminogen activator was administered, but symptoms progressed and NIHSS score increased up to 8. Diagnostic angiogrpahy confirmed presence of the subocclusive thrombus within the distal left M1 segment and complete occlusion of LSA at its origin. Since conservative therapy was ineffective, mechanical thrombectomy utilizing ADAPT (a direct aspiration first-pass thrombectomy) technique was performed resulting in compete recanalization of the LSA accompanied by the prompt regress of neurological symptoms. Eventally, the patient demonstrated nearly full recovery (modified Rankin Scale score 1). Thus, mechanical thrombectomy should be considered as a reasonable option in cases of acute cerebral stroke caused by subocclusive thrombus and progressive neurological deficits despite standard conservative therapy. J. Med. Invest. 67 : 372-374, August, 2020.


Assuntos
Doença Cerebrovascular dos Gânglios da Base/cirurgia , Trombose Intracraniana/cirurgia , Trombectomia/métodos , Idoso , Doença Cerebrovascular dos Gânglios da Base/complicações , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Infarto Cerebral/etiologia , Humanos , Trombose Intracraniana/complicações , Trombose Intracraniana/diagnóstico por imagem , AVC Isquêmico/etiologia , Masculino
13.
BMJ Case Rep ; 13(10)2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33028571

RESUMO

A 65-year-old woman presented to the emergency department with sudden onset of left-sided weakness, headache and vomiting. A cerebral CT showed an acute intracerebral haemorrhage involving the right caudate nucleus and lentiform nucleus with mild midline shift and intraventricular extension. CT angiography did not reveal aneurysm or other vascular anomaly. Conventional cerebral angiography demonstrated a 3 mm right medial lenticulostriate branch aneurysm, arising from the right anterior cerebral artery (ACA). Endovascular treatment was performed from the left internal carotid via the anterior communicating artery into the right ACA. Complete occlusion was achieved with injection of N-butyl-2-cyanoacrylate. The patient had neurological rehabilitation during hospitalisation followed by outpatient physical therapy. Two years later, clinical follow-up demonstrated excellent recovery.


Assuntos
Aneurisma Roto , Doença Cerebrovascular dos Gânglios da Base , Artérias Cerebrais/diagnóstico por imagem , Hemorragia Cerebral , Embolização Terapêutica/métodos , Procedimentos Endovasculares/métodos , Aneurisma Intracraniano , Idoso , Aneurisma Roto/diagnóstico , Aneurisma Roto/cirurgia , Doença Cerebrovascular dos Gânglios da Base/diagnóstico , Doença Cerebrovascular dos Gânglios da Base/cirurgia , Angiografia Cerebral/métodos , Hemorragia Cerebral/diagnóstico por imagem , Hemorragia Cerebral/etiologia , Hemorragia Cerebral/fisiopatologia , Hemorragia Cerebral/cirurgia , Feminino , Humanos , Aneurisma Intracraniano/complicações , Aneurisma Intracraniano/diagnóstico , Aneurisma Intracraniano/cirurgia , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
14.
BMC Neurol ; 20(1): 308, 2020 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-32814565

RESUMO

BACKGROUND: The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant. METHODS: Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin: lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis. Hemorrhage sites and collateral vessels were compared between patients with wild-type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching. RESULTS: A total of 130 hemorrhagic MMD patients were included in present study, 21 pairs (42 hemorrhagic hemispheres) were obtained after 1:1 propensity score. In GA group, 16 hemispheres (76.2%) presented anterior hemorrhage, and 5 hemispheres (23.8%) presented with posterior hemorrhage. In GG group, 13 hemispheres (61.9%) presented anterior hemorrhage, and 8 hemispheres (38.1%) presented with posterior hemorrhage. No significant differences were found in hemorrhagic sites between two matched groups (P > 0.05). Of 21 hemispheres in GA group, 10 (47.6%) exhibited lenticulostriate anastomosis, 6 (28.6%) thalamic anastomosis, and 6 (28.6%) choroidal anastomosis. Of 21 hemispheres in GG group, 3 (14.3%) exhibited lenticulostriate anastomosis, 5 (23.8%) thalamic anastomosis, and 9 (42.9%) choroidal anastomosis. There was significant difference in lenticulostriate anastomosis between two matched groups (P = 0.045). After adjustment the age, sex, and PCA involvement, we found that lenticulostriate anastomosis was associated with p.R4810K variant (OR, 5.995; 95% CI, 1.296-27.737; P = 0.022). CONCLUSION: Lenticulostriate anastomosis might be associated with p.R4810K variant. Whereas hemorrhagic sites, thalamic anastomosis, and choroidal anastomosis might not be associted withp.R4810K variant.


Assuntos
Circulação Colateral , Hemorragias Intracranianas/genética , Hemorragias Intracranianas/patologia , Doença de Moyamoya/genética , Doença de Moyamoya/patologia , Adenosina Trifosfatases/genética , Adulto , Doença Cerebrovascular dos Gânglios da Base/genética , Doença Cerebrovascular dos Gânglios da Base/patologia , Angiografia Cerebral , Feminino , Variação Genética , Heterozigoto , Humanos , Masculino , Doença de Moyamoya/complicações , Ubiquitina-Proteína Ligases/genética
15.
J Am Geriatr Soc ; 68(10): 2232-2239, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32511756

RESUMO

OBJECTIVES: We aimed to study the value of ambulatory blood pressure monitoring (ABPM) in predicting the global progression of cerebral small vessel disease (cSVD). DESIGN: Longitudinal cohort study. SETTING: Data from the population-based Investigating Silent Strokes in Hypertensives study. PARTICIPANTS: Individuals with hypertension who were 50 to 70 years of age and stroke free at baseline. In baseline and follow-up visits, patients underwent magnetic resonance imaging and ABPM. MEASUREMENTS: Ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels were studied as continuous variables and dichotomized according to good or poor control on the basis of 125/75 (24 hours), 130/80 (day), and 110/65 (night) mm Hg cutoff values. Whole cSVD progression was qualitatively scored with 1 point when an incident lesion (incident lacunar infarcts, deep cerebral microbleeds, white matter hyperintensities, and basal ganglia enlarged perivascular spaces) was detected. The score ranged from 0 to 4. RESULTS: We followed up 233 participants with a median age of 65 years within 4 years. A total of 61 (26.2%) and 23 (9.9%) subjects showed cSVD progression in one and two or more markers, respectively. Baseline ambulatory SBP and DBP and nighttime pulse pressure (PP) values were positively correlated with the number of incident cSVD lesions. Interestingly, patients without incident lesions showed greater differences between office and ambulatory BP, thus suggesting an increased white coat effect. Poor DBP control, nighttime PP, and DBP white coat effect were independently associated with cSVD progression. The inclusion of these metrics in a clinical model resulted in a significant increase in the prediction of incident lesions (integrated discrimination improvement = 9.09%; P value <.001). CONCLUSION: ABPM may help assess cSVD risk of progression, especially by the identification of poor BP control, masked hypertension, and increased nighttime PP. J Am Geriatr Soc 68:2232-2239, 2020.


Assuntos
Monitorização Ambulatorial da Pressão Arterial/estatística & dados numéricos , Pressão Sanguínea/fisiologia , Doenças de Pequenos Vasos Cerebrais/fisiopatologia , Hipertensão/fisiopatologia , Idoso , Doença Cerebrovascular dos Gânglios da Base/epidemiologia , Doença Cerebrovascular dos Gânglios da Base/etiologia , Hemorragia Cerebral/epidemiologia , Hemorragia Cerebral/etiologia , Doenças de Pequenos Vasos Cerebrais/complicações , Progressão da Doença , Feminino , Humanos , Hipertensão/complicações , Incidência , Leucoencefalopatias/epidemiologia , Leucoencefalopatias/etiologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Valores de Referência , Acidente Vascular Cerebral Lacunar/epidemiologia , Acidente Vascular Cerebral Lacunar/etiologia
16.
Neurology ; 95(9): e1174-e1187, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32586896

RESUMO

OBJECTIVE: To elucidate the timeframe and spatial patterns of cortical reorganization after different stroke-induced basal ganglia lesions, we measured cortical thickness at 5 time points over a 6-month period. We hypothesized that cortical reorganization would occur very early and that, along with motor recovery, it would vary based on the stroke lesion site. METHODS: Thirty-three patients with unilateral basal ganglia stroke and 23 healthy control participants underwent MRI scanning and behavioral testing. To further decrease heterogeneity, we split patients into 2 groups according to whether or not the lesions mainly affect the striatal motor network as defined by resting-state functional connectivity. A priori measures included cortical thickness and motor outcome, as assessed with the Fugl-Meyer scale. RESULTS: Within 14 days poststroke, cortical thickness already increased in widespread brain areas (p = 0.001), mostly in the frontal and temporal cortices rather than in the motor cortex. Critically, the 2 groups differed in the severity of motor symptoms (p = 0.03) as well as in the cerebral reorganization they exhibited over a period of 6 months (Dice overlap index = 0.16). Specifically, the frontal and temporal regions demonstrating cortical thickening showed minimal overlap between these 2 groups, indicating different patterns of reorganization. CONCLUSIONS: Our findings underline the importance of assessing patients early and of considering individual differences, as patterns of cortical reorganization differ substantially depending on the precise location of damage and occur very soon after stroke. A better understanding of the macrostructural brain changes following stroke and their relationship with recovery may inform individualized treatment strategies.


Assuntos
Doença Cerebrovascular dos Gânglios da Base/fisiopatologia , Infarto Encefálico/fisiopatologia , Córtex Cerebral/diagnóstico por imagem , Plasticidade Neuronal , Paresia/fisiopatologia , Recuperação de Função Fisiológica , Adulto , Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Infarto Encefálico/diagnóstico por imagem , Estudos de Casos e Controles , Córtex Cerebral/patologia , Feminino , Neuroimagem Funcional , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neostriado/diagnóstico por imagem , Neostriado/fisiopatologia , Vias Neurais , Tamanho do Órgão , Índice de Gravidade de Doença , Reabilitação do Acidente Vascular Cerebral
17.
Cir Cir ; 88(3): 366-369, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32538989

RESUMO

OBJECTIVE: To present an atypical case of deep intracerebral hemorrhage caused by the rupture of an aneurysm of the distal lenticulostriate artery. A 42-year-old woman presenting with right-sided mild hemiparesis was diagnosed with an acute left-sided hemorrhage within the basal nuclei. Cerebral angiography revealed a microaneurysm of the distal portion of the left lenticulostriate artery. Conservative treatment under close neurological surveillance was recommended. After a few days of hospital stay, the patient's neurological symptoms improved, and she was discharged. The patient has remained asymptomatic for more than 6 months. Aneurysms of the distal lenticulostriate artery are extremely rare.


OBJETIVO: Presentar un caso atípico de hemorragia intracerebral profunda causada por la ruptura de un aneurisma de la arteria lenticuloestriada distal; se revisa la bibliografía y se analizan la fisiopatología y el tratamiento. Se presentó a la sala de emergencias una mujer de 42 años con hemiparesia leve del hemicuerpo derecho. Se la diagnosticó con una hemorragia aguda en los núcleos de la base izquierdos. La panangiografía cerebral reveló un microaneurisma de la porción distal de la arteria lenticuloestriada izquierda. Se recomendó tratamiento conservador bajo estrecha vigilancia neurológica. Después de unos cuantos días de hospitalización, los síntomas neurológicos de la paciente mejoraron y la paciente recibió el alta. La paciente ha permanecido asintomática durante más de seis meses. Los aneurismas de la arteria lenticuloestriada distal son extremadamente raros.


Assuntos
Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Hemorragia Cerebral/etiologia , Aneurisma Intracraniano/complicações , Adulto , Doença Cerebrovascular dos Gânglios da Base/complicações , Doença Cerebrovascular dos Gânglios da Base/terapia , Angiografia Cerebral , Hemorragia Cerebral/complicações , Hemorragia Cerebral/diagnóstico , Hemorragia Cerebral/terapia , Angiografia por Tomografia Computadorizada , Tratamento Conservador , Feminino , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Imageamento por Ressonância Magnética , Paresia/etiologia
18.
Rev. peru. med. exp. salud publica ; 37(2): 229-238, abr.-jun. 2020. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1127156

RESUMO

RESUMEN Objetivos: Evaluar el riesgo de daño cerebral en prematuros menores de 34 semanas expuestos a corioamnionitis histológica (CAH). Materiales y métodos: Se realizó un estudio de cohortes en el Hospital Cayetano Heredia, durante el 2015. Fueron incluidos prematuros menores de 34 semanas que tuvieran examen histopatológico de la placenta. Los tipos de CAH evaluados fueron subcorionitis, corionitis, corioamnionitis, con o sin funisitis. El daño cerebral se evaluó en tres periodos de edad, entre 0 y 7 días, entre 7 y 30 días y a las 40 semanas gestacionales corregidas. Se realizó un seguimiento neurológico y controles con ecografía cerebral. Resultados: Se estudiaron 85 prematuros, 47,1% eran mujeres y la media de la edad gestacional fue de 30,9 semanas. El 42% (36/85) nacieron expuestos a CAH. La ruptura prematura de membrana fue la principal generatriz de sepsis, y la sepsis se relacionó con daño neurológico. La CAH estuvo asociada con hemorragia intraventricular (HIV) durante la primera semana y con lesiones de la sustancia blanca entre los 7 y 30 días de edad (p = 0,035). El tipo corioamnionitis de CAH se asoció al daño neurológico durante la primera semana (RR = 2,11; IC 95%: 1,09-4,11) y entre los 7 y 30 días de vida (RR = 2,72; IC 95%: 1,07-6,88). Conclusiones: La corioamnionitis fue un factor de riesgo para desarrollar lesiones cerebrales en prematuros menores de 34 semanas, para HIV durante los primeros 7 días y lesiones de sustancia blanca entre los 7 y los 30 días de edad. A las 40 semanas de edad corregida, los prematuros extremos con CAH tuvieron lesiones cerebrales más extensas.


ABSTRACT Objectives: To assess the risk of brain damage in premature infants under 34 weeks of gestational age exposed to histological chorioamnionitis (HCA). Materials and methods: A cohort study was conducted at the Hospital Cayetano Heredia, during 2015. Premature infants under 34 weeks of gestational age, who had histopathological examination of the placenta, were included. The types of HCA evaluated were sub-chorionitis, chorionitis, chorioamnionitis, with or without funisitis. Brain damage was evaluated in three age periods, between 0 and 7 days, between 7 and 30 days and at 40 weeks of corrected gestational age. A neurological follow-up and regular controls were performed with brain ultrasound. Results: A total of 85 premature infants were included, 47.1% were women and the mean gestational age was 30.9 weeks. From the total, 42% (36/85) were born exposed to HCA. Premature rupture of membranes was the main cause of sepsis, which was related to neurological damage. HCA was associated with intraventricular hemorrhage (IVH) during the first week and with white matter lesions between 7 and 30 days of age (p = 0.035). The chorioamnionitis type of HCA was associated with neurological damage during the first week (RR = 2.11, 95% CI: 1.09-4.11) and between 7 and 30 days of age (RR = 2.72, 95% CI: 1.07-6.88). Conclusions: Chorioamnionitis was a risk factor for developing brain injuries in premature infants under 34 weeks of gestational age. It was also a risk factor for HIV during the first 7 days and for white matter injuries between 7 and 30 days of age. At 40 weeks of corrected gestational age, extreme premature infants with HCA had more extensive brain damage.


Assuntos
Humanos , Recém-Nascido , Efeitos Tardios da Exposição Pré-Natal , Lesões Encefálicas , Recém-Nascido Prematuro , Corioamnionite , Doença Cerebrovascular dos Gânglios da Base , Doenças do Prematuro , Neonatologia , Neurologia , Peru/epidemiologia , Leucomalácia Periventricular , Lesões Encefálicas/epidemiologia , Risco , Estudos de Coortes , Corioamnionite/epidemiologia , Idade Gestacional , Hemorragia Cerebral Intraventricular , Doenças do Prematuro/epidemiologia
19.
Acta méd. colomb ; 45(2): 45-48, Jan.-June 2020. graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-1130691

RESUMO

Moyamoya disease is a chronic neurovascular disease characterized by progressive bilateral stenosis of the internal carotid arteries with abnormal formation of new abnormal blood vessels whose blockage of blood flow causes a variety of clinical manifestations and complications associated with acute cerebrovascular events (ischemic or hemorrhagic), which may even be fatal. This article seeks to describe this entity, its incidence, prevalence, forms of presentation, therapeutic measures and prognosis through a clinical case report. (Acta Med Colomb 2020; 45. DOI:http://doi.org/10.36104/amc.2020.1424).


La enfermedad de Moyamoya es una enfermedad neurovascular crónica caracterizada por una estenosis progresiva bilateral de las arterias carótidas internas, con la formación anormal de nuevos vasos sanguíneos, cuyo bloqueo en flujo sanguíneo ocasiona variadas manifestaciones clínicas y complicaciones asociadas a eventos cerebrovasculares (isquémicos o hemorrágicos) agudos que pueden llegar a ser incluso mortales. El presente artículo pretende realizar una aproximación acerca de esta entidad, su incidencia, prevalencia, formas de presentación y medidas terapéuticas y pronostico mediante el reporte de un caso clínico.(Acta Med Colomb 2020; 45. DOI:https://doi.org/10.36104/amc.2020.1424).


Assuntos
Humanos , Feminino , Adulto , Doença de Moyamoya , Prognóstico , Vasos Sanguíneos , Artérias Carótidas , Transtornos Cerebrovasculares , Prevalência , Doença Cerebrovascular dos Gânglios da Base
20.
Clin Neurol Neurosurg ; 192: 105706, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32058199

RESUMO

OBJECTIVES: Incidence rate of basal ganglia infarction (BGI) after mild head trauma was reported higher in children with basal ganglia calcification (BGC). We would like to review patients with BGC showed in head CT scan to see the incidence rate of stroke in these patients and the correlation of variables in these cases. PATIENTS AND METHODS: CT imaging data of cases with diagnosis of mild traumatic brain injury (mTBI) in a large tertiary pediatric center between Mar. 2014 and Mar. 2019 was retrospectively reviewed. Cases with findings of punctate calcification in the region of basal ganglion in CT scan were included. Correlation of variables of these cases (age, side and volume of basal ganglion calcification) with the diagnosis of BGI was the focus of this study. RESULTS: 37 patients (26 males, 9 females, median age: 3.88±3.54) were included in this study. 17 cases (45.9 %) were diagnosed of BGI and were admitted into the department of neurosurgery. Altogether 63 sides of BGC were categorized into two groups based on whether BGI happened and ROC curve was drawn. ROC curve showed when the cut-off point was 6.55 mm3, the sensitivity was 88.9 % and the specificity was 87.5 %; the area under curve was 0.849 (p<0.01). All the cases were divided into two groups according to whether basal ganglia infarction occurred or not. Mann-Whitney U test showed significant difference between these two groups in age (p=0.01). ROC curve of how age affect BGI after mTBI were drawn. The cut-off point was 3.25 years, and the sensitivity was 65.0 % and the specificity was 88.2 %; the area under curve was 0.746 (p=0.01). All patients received conservative treatment and recovered. CONCLUSION: Incidence rate is higher in children with BGC after mild head injury than that of other children. Larger BGC volume indicates higher risk of developing infarction after minor head injury. Older children with BGC are less-likely getting BGI after mTBI.


Assuntos
Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem , Concussão Encefálica/diagnóstico por imagem , Infarto Encefálico/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Adolescente , Doença Cerebrovascular dos Gânglios da Base/epidemiologia , Doenças dos Gânglios da Base/diagnóstico por imagem , Doenças dos Gânglios da Base/epidemiologia , Concussão Encefálica/epidemiologia , Infarto Encefálico/epidemiologia , Calcinose/epidemiologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Tomografia Computadorizada Multidetectores
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