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1.
Rev. colomb. cir ; 38(2): 363-368, 20230303. fig
Artigo em Espanhol | LILACS | ID: biblio-1425217

RESUMO

Introducción. El angiosarcoma es una neoplasia vascular originada a nivel del endotelio, de baja frecuencia, conocido por su agresividad y crecimiento acelerado. Alcanza solo el 1 al 2 % del total de los sarcomas. La presentación gastrointestinal es infrecuente y su incidencia es poco conocida debido al escaso reporte de casos en la literatura. Suele identificarse en etapas avanzadas debido a la dificultad del diagnóstico histopatológico por sus características morfológicas, siendo necesario aplicar tinciones especiales o estudio inmunohistoquímico. Caso clínico. Por su interés y singularidad, presentamos el caso de un paciente masculino de 54 años, quien consultó con hemorragia digestiva profusa, anemización y requerimiento de terapia transfusional. Resultados. Durante el proceso diagnóstico, en la endoscopia encontraron diversas lesiones multifocales que se extendían por gran parte del tracto gastrointestinal. El estudio histopatológico mostró angiosarcoma gastrointestinal. Discusión. El angiosarcoma del tracto gastrointestinal es extremadamente infrecuente, de difícil diagnóstico y bajas posibilidades de manejo curativo, con opciones terapéuticas limitadas, lo que configura un mal pronóstico a corto plazo


Introduction. Angiosarcoma is a vascular neoplasm originating from endothelial cells, known for its aggressiveness, accelerated growth and reduced frequency. Reach only 1 to 2% of total sarcomas. Gastrointestinal presentation is extremely rare, the true incidence is poorly known, due to the limited reports of this entity in the literature. It is usually identified in advanced stages in view of the difficulty of the histopathological diagnosis, attributable to its morphological characteristics, being necessary to apply special stains or immunohistochemical study. Case report. Due to their interest and uniqueness, we present the case of a 54-year-old male patient, who presented with a profuse gastrointestinal bleeding, anemia, and requirement for transfusion therapy. Results. The endoscopy detected several multifocal lesions that extended most of the gastrointestinal tract. The histopathological study showed gastrointestinal angiosarcoma. Discussion. Angiosarcoma of the gastrointestinal tract is extremely uncommon, difficult to diagnose and has low possibilities of curative management, with limited therapeutic options, which configures a poor prognosis in the short term


Assuntos
Humanos , Neoplasias Gastrointestinais , Hemangiossarcoma , Sarcoma , Tumores de Vasos Linfáticos , Hemorragia Gastrointestinal , Neoplasias de Tecido Vascular
2.
An Bras Dermatol ; 95(2): 214-216, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32151408

RESUMO

Papillary intralymphatic angioendothelioma (Dabska tumor) is a rarely metastasizing lymphatic vascular neoplasm that usually affects children and young adults. The majority of these cases occur in soft tissues of extremities, and to date less than 40 cases have been described. Despite the generally indolent evolution, can be locally invasive with the potential to metastasize. We describe a case of a young woman presenting with a plantar lesion, for 9 months and histological diagnosis of Dabska tumor. This neoplasm should be considered in the differential diagnosis of vascular dermatoses, allowing early diagnosis and treatment. Long-term follow-up should be performed.


Assuntos
Doenças do Pé/patologia , Hemangioendotelioma/patologia , Tumores de Vasos Linfáticos/patologia , Adulto , Biópsia , Dermoscopia , Diagnóstico Diferencial , Feminino , Doenças do Pé/diagnóstico , Hemangioendotelioma/diagnóstico , Humanos , Tumores de Vasos Linfáticos/diagnóstico , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia
3.
An. bras. dermatol ; 95(2): 214-216, Mar.-Apr. 2020. graf
Artigo em Inglês | LILACS, Coleciona SUS | ID: biblio-1130843

RESUMO

Abstract Papillary intralymphatic angioendothelioma (Dabska tumor) is a rarely metastasizing lymphatic vascular neoplasm that usually affects children and young adults. The majority of these cases occur in soft tissues of extremities, and to date less than 40 cases have been described. Despite the generally indolent evolution, can be locally invasive with the potential to metastasize. We describe a case of a young woman presenting with a plantar lesion, for 9 months and histological diagnosis of Dabska tumor. This neoplasm should be considered in the differential diagnosis of vascular dermatoses, allowing early diagnosis and treatment. Long-term follow-up should be performed.


Assuntos
Humanos , Feminino , Adulto , Tumores de Vasos Linfáticos/patologia , Doenças do Pé/patologia , Hemangioendotelioma/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia , Biópsia , Tumores de Vasos Linfáticos/diagnóstico , Dermoscopia , Diagnóstico Diferencial , Doenças do Pé/diagnóstico , Hemangioendotelioma/diagnóstico
5.
HNO ; 62(1): 12-8, 2014 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-24434958

RESUMO

The therapy of vascular tumors and malformations should be interdisciplinary and performed according to available guidelines. Infantile hemangiomas (IH) are the most frequent vascular tumors of childhood and do not require treatment in most cases. If the IH is complicated by its location (e.g. facial or genital) or if the lesion threatens to cause loss of function, small localized IH should be treated by laser- or cryotherapy. If the IH is diffuse or rapidly growing it can be successfully treated using the ß blocker propranolol. The mechanism underlying the efficacy of this medication-based therapy is not completely understood and this still represents an experimental therapy. The results of molecular studies on vascular malformations have indicated new strategies for medical therapies. However, lymphatic malformations (LM) are still treated by surgery where possible, or sclerotherapy. Further investigations are necessary to determine whether new drugs such as the mTOR inhibitor rapamycin may be effective for treatment of diffuse LM. First case reports seem to be promising.


Assuntos
Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Hemangioma/tratamento farmacológico , Anormalidades Linfáticas/tratamento farmacológico , Tumores de Vasos Linfáticos/tratamento farmacológico , Propranolol/uso terapêutico , Sirolimo/uso terapêutico , Antibióticos Antineoplásicos/uso terapêutico , Feminino , Hemangioma/diagnóstico , Humanos , Lactente , Recém-Nascido , Masculino , Vasodilatadores/uso terapêutico
6.
HNO ; 62(1): 6-11, 2014 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-24343056

RESUMO

Lymphatic malformations are congenital abnormalities of the lymphatic system which occur predominantly in the head and neck region. According to their dominant clinical and morphological characteristics, these are classified into micro- and macrocystic forms. Established therapies for lymphatic malformations include conventional surgery, sclerotherapy and laser treatment. Despite the significant improvements in therapeutic options seen in recent years, treatment of extensive lymphatic malformations remains an interdisciplinary challenge. Close-knit interdisciplinary cooperation is necessary to provide optimized care for affected individuals.


Assuntos
Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/terapia , Anormalidades Linfáticas/diagnóstico , Anormalidades Linfáticas/terapia , Tumores de Vasos Linfáticos/diagnóstico , Tumores de Vasos Linfáticos/terapia , Soluções Esclerosantes/uso terapêutico , Diagnóstico por Imagem/métodos , Cabeça/diagnóstico por imagem , Cabeça/patologia , Humanos , Terapia a Laser/métodos , Pescoço/diagnóstico por imagem , Pescoço/patologia , Radiografia , Escleroterapia/métodos
8.
Urology ; 82(2): e11-2, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23896118

RESUMO

Renal lymphangiomatosis is a rare disease characterized by lymphatic vessel proliferation. We present a case of an adult patient with chronic flank pain, hypertension, and a right kidney mass. The magnetic resonance imaging findings were consistent with unilateral renal lymphangiomatosis. Technetium-99m dimercaptosuccinic acid renal scintilography revealed decreased ipsilateral renal function. From these findings, the patient underwent right nephrectomy, which resulted in complete remission of his hypertension and pain.


Assuntos
Hipertensão/etiologia , Neoplasias Renais/complicações , Neoplasias Renais/diagnóstico , Tumores de Vasos Linfáticos/complicações , Tumores de Vasos Linfáticos/diagnóstico , Adulto , Humanos , Neoplasias Renais/cirurgia , Tumores de Vasos Linfáticos/cirurgia , Imageamento por Ressonância Magnética , Masculino , Nefrectomia
9.
Clin Imaging ; 37(2): 211-8, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23465970

RESUMO

OBJECTIVE: The purpose of our article is to review the magnetic resonance imaging (MRI) features of nongynaecologic cystic lesions of the pelvis. CONCLUSION: The rising use of MRI for pelvic exploration will result in an increase in incidental detection of pelvic cystic cysts. Pelvic cysts of non gynecologic origin are less frequent than gynecologic cysts. However, they account for a wide range of abnormalities, and radiologists must be aware of their features and characteristics.


Assuntos
Cistos/diagnóstico , Imageamento por Ressonância Magnética/métodos , Pelve , Cordoma/diagnóstico , Meios de Contraste , Humanos , Tumores de Vasos Linfáticos/diagnóstico , Linfocele/diagnóstico , Meningocele/diagnóstico , Neoplasias Embrionárias de Células Germinativas/diagnóstico , Doenças Peritoneais/diagnóstico
10.
J Craniomaxillofac Surg ; 41(5): 437-43, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23270683

RESUMO

OBJECTIVE: To determine the epidemiology, histological diagnosis and treatment outcome of oro-facial tumours and tumour-like lesions in Greek children and adolescents. MATERIAL AND METHODS: The medical records of patients with oro-facial lesions who presented at the Department of Oral and Maxillofacial Surgery at "A. & P. Kyriakou" Children's Hospital from 2000 to 2010 were reviewed. Data was analyzed in relation to age, gender, location, histology, treatment choice and outcome. RESULTS: Two hundred and eleven oro-facial lesions were identified. Age ranged from 14 days to 15 years (mean 8 years); the male-to-female ratio was 1.09: 1; 90.05% of the lesions were benign and 9.95% malignant. Vascular anomalies were the most common benign lesion (22.1%) and rhabdomyosarcoma was the most prevalent malignancy (28.57%). One hundred and ten lesions (52.1%) involved soft tissue, most commonly the tongue and 96 cases (45.5%), involved hard tissue, most frequently the mandible; 5 lesions (2.4%) involved both hard and soft tissue. Surgery was performed under general anaesthesia in 198 cases (93.84%). Some malignant lesions were treated with chemotherapy and/or radiotherapy. CONCLUSIONS: Oro-facial tumours and tumour-like lesions are not uncommon in the Greek paediatric population; although most frequently benign, these may cause considerable morbidity. As such early diagnosis and treatment are imperative.


Assuntos
Neoplasias Faciais/epidemiologia , Neoplasias Bucais/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Seguimentos , Grécia/epidemiologia , Humanos , Lactente , Recém-Nascido , Tumores de Vasos Linfáticos/epidemiologia , Masculino , Neoplasias Mandibulares/epidemiologia , Terapia Neoadjuvante/estatística & dados numéricos , Neoplasias de Tecido Vascular/epidemiologia , Tumores Odontogênicos/epidemiologia , Procedimentos Cirúrgicos Bucais/estatística & dados numéricos , Estudos Retrospectivos , Rabdomiossarcoma/epidemiologia , Neoplasias de Tecidos Moles/epidemiologia , Neoplasias da Língua/epidemiologia , Resultado do Tratamento
11.
Lymphat Res Biol ; 9(4): 205-12, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22196287

RESUMO

Lymphatic malformations and lymphatic-derived tumors commonly involve the head and neck, where they may be associated with bony abnormalities and other systemic symptoms. The reasons for the association between these disorders and local skeletal changes are largely unknown, but such changes may cause significant disease-related morbidity. Ongoing work in molecular and developmental biology is beginning to uncover potential reasons for the bony abnormalities found in head and neck lymphatic disease; this article summarizes current knowledge on possible mechanisms underlying this association.


Assuntos
Doenças Ósseas/diagnóstico , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/metabolismo , Tumores de Vasos Linfáticos/diagnóstico , Tumores de Vasos Linfáticos/metabolismo , Doenças Ósseas/complicações , Doenças Ósseas/diagnóstico por imagem , Osso e Ossos/metabolismo , Osso e Ossos/patologia , Células Endoteliais/metabolismo , Matriz Extracelular/metabolismo , Matriz Extracelular/patologia , Neoplasias de Cabeça e Pescoço/complicações , Humanos , Tumores de Vasos Linfáticos/complicações , Radiografia , Transdução de Sinais
13.
Cancer Lett ; 305(2): 144-9, 2011 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-21172728

RESUMO

Epstein-Barr virus (EBV) a ubiquitous gamma herpesvirus persists for life, generally without health consequences. However, it is associated with several well-recognized malignancies, such as Burkitt's lymphoma and nasopharyngeal carcinoma. A growing list of malignancies has been proposed to be EBV-associated: most of which are consistently EBV-positive whereas others show inconsistent results. The possible contribution of EBV to the development and/or progression of different "non-classical" tumors is discussed in terms of putative "non-traditional'' infection in EBV-related tumors.


Assuntos
Neoplasias da Mama/virologia , Neoplasias Hepáticas/virologia , Tumores de Vasos Linfáticos/virologia , Neoplasias da Mama/complicações , Carcinoma/complicações , Carcinoma/virologia , Progressão da Doença , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/virologia , Feminino , Herpesvirus Humano 4/imunologia , Humanos , Neoplasias Hepáticas/complicações , Tumores de Vasos Linfáticos/complicações , Modelos Biológicos , Neoplasias das Glândulas Salivares/complicações , Neoplasias das Glândulas Salivares/virologia , Neoplasias Gástricas/complicações , Neoplasias Gástricas/virologia , Neoplasias do Colo do Útero/complicações , Neoplasias do Colo do Útero/virologia
14.
Rev. esp. patol ; 43(4): 241-243, oct.-dic. 2010.
Artigo em Espanhol | IBECS | ID: ibc-82958

RESUMO

Las inclusiones benignas glandulares en ganglios linfáticos axilares son lesiones muy poco comunes y su interpretación histológica puede ser realizada erróneamente como metástasis de carcinoma de mama. Este problema es aún mayor en estudios intraoperatorios de ganglio centinela de mama en los que puede ser causa de falsos positivos y conducir a un innecesario vaciamiento ganglionar axilar, con la morbilidad que ello conlleva. Presentamos un caso de una paciente con carcinoma de mama en cuya intervención quirúrgica se remitió un ganglio centinela para estudio intraoperatorio que contenía inclusiones benignas glandulares y que ilustra la necesidad de conocer esta patología para evitar sobretratamiento(AU)


Benign glandular inclusions in axillary lymph nodes are very rare lesions which may be mistaken for metastatic carcinoma of the breast. This problem is exacerbated when sentinel nodes are studied intraoperatively during breast surgery, as misdiagnosis can result in false positives leading to unnecessary axillary lymph node dissection and the increased associated morbidity. We report a case of a patient with breast cancer who underwent surgery and the interaoperative histology of the sentinel node revealed the presence of benign glandular inclusions. The diagnostic problem illustrated by this case, together with the importance of avoiding overtreatment, is discussed(AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias Epiteliais e Glandulares/patologia , Biópsia de Linfonodo Sentinela/métodos , Neoplasias da Mama/patologia , Carcinoma/patologia , Diagnóstico Diferencial , Linfonodos/patologia , Tumores de Vasos Linfáticos/patologia , Hiperplasia/complicações , Hiperplasia/patologia
15.
Actas dermo-sifiliogr. (Ed. impr.) ; 101(9): 792-797, nov. 2010. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-83463

RESUMO

El linfangioma progresivo adquirido es una neoplasia vascular poco frecuente, de comportamiento localmente agresivo. Histológicamente se caracteriza por la proliferación de múltiples vasos dilatados de paredes finas, revestidos con un endotelio plano sin atipias y que aparentemente disecan las fibras de colágeno. Esta entidad suele debutar de forma asintomática como una placa marrón-eritematosa que presenta un crecimiento gradual. Se presenta un caso de linfangioma progresivo adquirido en un varón de 32 años. La tumoración se localizaba en el hipogastrio sobre una lesión vascular congénita diagnosticada previamente de angiomatosis cutánea multifocal. Clínicamente cursaba con intenso dolor e imposibilidad para la deambulación por lo que fue resecada. El linfangioma progresivo adquirido debe ser considerado por dermatólogos y patólogos dado que su tratamiento quirúrgico precoz, cuando la lesión tiene un tamaño limitado, es siempre curativo y evita posteriores complicaciones derivadas de su crecimiento (AU)


Acquired progressive lymphangioma is a rare vascular tumor with a locally aggressive behavior. Histologically it is characterized by a proliferation of numerous, dilated, thin-walled vessels lined by flat endothelial cells with no nuclear atypia. The vessels appear to dissect between the collagen fibers. It usually presents as an asymptomatic, slow-growing, reddish-brown plaque. We present the case of a 32-year-old man with acquired progressive lymphangioma. The tumor was in the hypogastric region and had arisen on a congenital vascular lesion previously diagnosed as multifocal cutaneous angiomatosis. It was very painful and impeded walking, for which reason it was decided to perform excision. Dermatologists and pathologists must be aware of acquired progressive lymphangioma as early surgical treatment, while the lesion is still small, is curative and prevents subsequent complications due to growth (AU)


Assuntos
Humanos , Masculino , Adulto , Linfangioma/diagnóstico , Neoplasias Vasculares/diagnóstico , Tumores de Vasos Linfáticos/diagnóstico
18.
Clin Cancer Res ; 15(8): 2637-46, 2009 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-19351758

RESUMO

PURPOSE: Unlike carcinomas, soft-tissue sarcoma (STS) rarely exhibit lymphatic spread. Consequently, we examined expression and function of vascular endothelial growth factor (VEGF)-C and STS-associated lymphatic vessel density (LVD) components of this process. EXPERIMENTAL DESIGN: VEGF-C and VEGF-A mRNA and VEGF-C protein expression were evaluated in STS, STS cell lines, and breast cancers (reverse transcription-PCR, quantitative reverse transcription-PCR, and ELISA). STS cell conditioned medium after VEGF-C knockdown was examined for endothelial cell proliferation and migration effects (MTS and migration assays). Paraffin-embedded human lymph node-negative and lymph node-positive STS and lymph node-negative and lymph node-positive breast cancers were examined for VEGF-C, D2-40, and CD31 expression (immunohistochemistry). LVD differences were analyzed by Wilcoxon rank-sum tests. RESULTS: STS and breast cancer VEGF-C expression was comparable and higher than normal tissue levels. STS cells secreted functional VEGF-C: STS conditioned medium induced lymphatic endothelial cell proliferation and migration, which was abrogated by STS cell VEGF-C knockdown. STS and breast cancer intratumoral LVD was similar. STS peritumoral LVD (PT-LVD) was reduced versus breast cancer PT-LVD (P < 0.001). Significantly higher PT-LVD was observed in lymph node-positive versus lymph node-negative STS; lymphatic spreading STS subtypes also had higher LVD. STS VEGF-C expression and PT-LVD lacked correlation, and many lymph node-negative STS had high PT-LVD, suggesting complexity in this metastatic process. CONCLUSIONS: Compared with breast cancers, STS exhibited lower PT-LVD independent of VEGF-C expression, which may underlie STS lymph node metastasis rarity. Moreover, lymphatic vessels appear necessary but not sufficient to sustain STS lymphatic spread. Examining STS "nonlymphatic" dissemination may help elucidate mechanisms of lymphatic spread, insights critically important to cancer metastasis control.


Assuntos
Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Sarcoma/patologia , Fator C de Crescimento do Endotélio Vascular/biossíntese , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Linhagem Celular Tumoral , Movimento Celular/fisiologia , Células Endoteliais/fisiologia , Técnicas de Silenciamento de Genes , Humanos , Metástase Linfática , Tumores de Vasos Linfáticos/metabolismo , RNA Interferente Pequeno/metabolismo , Sarcoma/metabolismo , Fator C de Crescimento do Endotélio Vascular/genética
19.
Rev. senol. patol. mamar. (Ed. impr.) ; 22(5): 185-192, 2009. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-75771

RESUMO

La extensión de los programas poblacionales para la detecciónprecoz del cáncer de mama y la mejora en los métodosde imagen, han permitido el diagnóstico de tumores de mamaen estadios iniciales, con menor probabilidad de afectaciónaxilar.A su vez, esto ha impulsado el desarrollo de métodos terapéuticosmenos agresivos para el cáncer de mama, como la cirugíaconservadora o la biopsia selectiva del ganglio centinela.Dado el abanico de posibilidades terapéuticas para el cáncerde mama y las tendencias a un tratamiento individualizadobasado en las características propias de cada paciente, se hacenecesaria una correcta estadificación con el fin de elegir la mejoropción terapéutica en cada caso.En este sentido, la valoración ecográfica ganglionar axilarha cobrado gran importancia en los últimos años en el cáncerde mama. Esta técnica ha demostrado que es capaz no sólo devalorar las características morfológicas de los ganglios axilaresy del resto de cadenas ganglionares, sino también de orientary dirigir la biopsia percutánea de los ganglios sospechosos, yde este modo seleccionar de forma precisa las pacientes candidatasde biopsia selectiva del ganglio centinela.En el presente trabajo se valora la aportación de la ecografíay biopsia percutánea ganglionar axilar en pacientes concáncer de mama(AU)


Breast cancer screening programs and improved imagingtechniques have made it possible to detect breast cancer in theearly stages when axillary involvement is less likely. Early detectionhas led to less aggressive treatments for breast cancerlike conservative surgery and sentinel lymph node biopsy.Given the wide variety of therapeutic alternatives for breastcancer and the trend toward tailoring treatment to each patient’scharacteristics, correct staging is crucial to ensure thebest treatment option is chosen in each case.In this sense, ultrasonographic evaluation of lymph nodesin patients with breast cancer has become increasingly importantin recent years. Ultrasonography has proven to be effectivenot only in the evaluation of the morphological characteristicsof the axillary lymph nodes and other lymph node chainsbut also in guiding percutaneous biopsy of suspicious lymphnodes to accurately select candidates for sentinel lymph nodebiopsy.This study evaluates the contribution of ultrasonographyand percutaneous biopsy of axillary lymph nodes in patientswith breast cancer(AU)


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Axila/patologia , Axila , Neoplasias da Mama/diagnóstico , Linfonodos/patologia , Linfonodos , Tumores de Vasos Linfáticos , Técnicas Citológicas/métodos , Técnicas Citológicas/tendências , Técnicas Citológicas , Vasos Linfáticos , Biópsia/métodos
20.
Rev. neurol. (Ed. impr.) ; 47(9): 464-468, 1 nov., 2008. ilus
Artigo em Es | IBECS | ID: ibc-70548

RESUMO

Introducción. El pseudotumor inflamatorio es un proceso reactivo de etiología y patogenia no bien definida que sepuede encontrar en cualquier localización. Los casos con afección del sistema nervioso central se han descrito en meninges, parénquima cerebral, plexos coroides y nervios craneales y espinales. Se han descrito casos multicéntricos, tanto sincrónicos como asincrónicos. Caso clínico. Mujer de 45 años portadora de una enfermedad reumatológica (espondiloartropatía seronegativa) a quien se le encontró un pseudotumor inflamatorio multicéntrico con afección del bazo, el hígado y los ganglios linfáticos paraaórticos asociado a fiebre de origen desconocido en 1995, y seis años después presentó una lesión similar en las meninges de la convexidad frontoparietal derecha, la cual se acompañó de fiebre, ataque al estado general, incremento de la velocidad de sedimentación globular, anemia microcítica hipocrómica y trombocitosis, que remitieron al resecar la lesión.Conclusión. Se revisan las características clinicopatológicas de esta entidad, así como las diferentes teorías que se han propuesto en relación con la etiología y patogenia, incluyendo las referentes a las manifestaciones sistémicas y alteraciones enlos exámenes de laboratorio asociadas a estas lesiones, que se presentan en un 15-30% de los casos y que están mediadas por citocinas producidas por las células inflamatorias del tumor


Introduction. Inflammatory pseudotumor is a reactive process in which the etiology and pathogenesis are not well defined, that can be found in any location. The cases with central nervous system affection have been described in meninges, brain, choroid plexus and cranial and spinal nerves. Multicentric cases, synchronous and asynchronous have been described.Case report. A 45 years-old woman with a rheumatologic disease (a seronegative spondiloarthropathy) who developed an inflammatory pseudotumor in spleen, liver and abdominal lymph nodes in 1995, associated to fever of unknown origin, six years later she presented with an inflammatory pseudotumor of the meninges in the convexity of the right frontoparietal region, with fever, malaise, and increase of globular sedimentation rate, microcytic hypochromic anemia and thrombocytosis.Conclusion. The clinicopathologic features of this lesion are revised, including the different theories in regard to the etiology and pathogenesis, and the role of cytokines produced by inflammatory cells in the tumor


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Espondiloartropatias/complicações , Granuloma de Células Plasmáticas/complicações , Neoplasias Meníngeas/diagnóstico , Neoplasias Hepáticas/diagnóstico , Neoplasias Esplênicas/diagnóstico , Tumores de Vasos Linfáticos/diagnóstico , Febre de Causa Desconhecida/etiologia
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