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1.
J. appl. oral sci ; 21(3): 256-264, May/Jun/2013. ilus, tab, graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-874840

RESUMO

Our research aimed to look into the clinical traits and genetic mutations in sporadic non-syndromic anodontia and to gain insight into the role of mutations of PAX9, MSX1, AXIN2 and EDA in anodontia phenotypes, especially for the PAX9.Material and MethodsThe female proband and her family members from the ethnic Han families underwent complete oral examinations and received a retrospective review. Venous blood samples were obtained to screen variants in the PAX9, MSX1, AXIN2, and EDA genes. A case-control study was performed on 50 subjects with sporadic tooth agenesis (cases) and 100 healthy controls, which genotyped a PAX9 gene polymorphism (rs4904210).ResultsIntra-oral and panoramic radiographs revealed that the female proband had anodontia denoted by the complete absence of teeth in both the primary and secondary dentitions, while all her family members maintained normal dentitions. Detected in the female proband were variants of the PAX9 and AXIN2 including A240P (rs4904210) of the PAX9, c.148C>T (rs2240308), c.1365A>G (rs9915936) and c.1386C>T (rs1133683) of the AXIN2. The same variants were present in her unaffected younger brother. The PAX9 variations were in a different state in her parents. Mutations in the MSX1 and EDA genes were not identified. No significant diferences were found in the allele and genotype frequencies of the PAX9 polymorphism between the controls and the subjects with sporadic tooth agenesis.ConclusionsThese results suggest that the association of A240P with sporadic tooth agenesis still remains obscure, especially for different populations. The genotype/phenotype correlation in congenital anodontia should be verified.


Assuntos
Humanos , Masculino , Feminino , Anodontia/genética , Predisposição Genética para Doença , Fator de Transcrição PAX9/genética , Polimorfismo Genético/genética , Estudos de Casos e Controles , China , Ectodisplasinas/genética , Frequência do Gene , Estudos de Associação Genética , Fator de Transcrição MSX1/genética , Linhagem , Radiografia Panorâmica , Estudos Retrospectivos
2.
Rev. ABO nac ; 6(3): 134-7, jun.-jul. 1998. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-872243

RESUMO

Países como Chile, China, Bulgária e Inglaterra aplicam flúor no leite para combater a cárie infantil. Alternativa é recomendada pela Organização Mundial da Saúde (OMS) onde não é possível implantar a fluoretação do sal ou até mesmo da água. No Brasil, a água fluorada vem diminuindo drasticamente a incidência de cáries na população


Assuntos
Criança , Cárie Dentária , Halogenação , Flúor , Leite , Brasil/epidemiologia , Bulgária/epidemiologia , Chile/epidemiologia , China/epidemiologia , Inglaterra/epidemiologia
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