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3.
Eur. j. anat ; 23(5): 383-388, sept. 2019. ilus, graf, tab
Artigo em Inglês | IBECS | ID: ibc-183869

RESUMO

Langerhans cells (LCs) are the most effective antigen presenting cells against foreign bodies and carcinogens. Since the oral cavity is a portal of entry for these antigens, the aim of this study was to morphologically classify CD1a+ LCs, quantify them in the normal and malignant buccal mucosa, and evaluate their relation to the age of patients. Healthy buccal mucosal samples collected from 16 patients undergoing reconstructive operation, and malignant samples obtained from 15 patients undergoing radical oncological resection. were processed for immunohistochemistry four- to fivemicron thick sections were stained with CD1a antibody (CD1a). At 40X magnification, CD1a+ LCs were morphologically classified and quantified manually for a 25mm length of basement membrane using Cellsens image analysing software and the data was analysed. Two categories of CD1a+ LCs were identified in the normal and malignant buccal mucosa a) typical dendritic LCs and b) non-dendritic LCs (a new entity). Non-dendritic LCs were of significantly higher number compared to the typical dendritic LCs in the normal tissues (p -0.001). In the malignant group, the non-dendritic CD1a+ LCs were significantly fewer in number (p0.004), when compared to the normal group. Nondendritic LCs were also significantly fewer (p0.026) in patients over 60 years of age. This is the first report of non-dendritic Langerhans cells in normal buccal mucosa and malignant buccal mucosa using the CD1a marker. The significantly higher number of these cells in normal tissues and younger individuals supports their role as accessory antigen presenting cells


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Células de Langerhans/patologia , Mucosa Bucal/anatomia & histologia , Mucosa Bucal/patologia , Células de Langerhans/efeitos dos fármacos , Mucosa Bucal/citologia , Antígenos CD1
4.
Med. oral patol. oral cir. bucal (Internet) ; 24(4): e452-e460, jul. 2019. graf, tab, ilus
Artigo em Inglês | IBECS | ID: ibc-185658

RESUMO

Background: The aim of this systematic review was to summarise the clinical information available about oral mucosal peeling (OMP) and to explore its aetiopathogenic association with dentifrices and mouthwashes. Material and Methods: PICOS outline: Population: subjects diagnosed clinically and/or pathologically. Intervention: exposition to oral hygiene products. Comparisons: patients using products at different concentrations. Out-comes: clinicopathological outcomes (primary) and oral epithelial desquamation (secondary) after use. Study de-sign: any. Exclusion criteria: reports on secondary or unpublished data, in vitro studies. Data were independently extracted by two reviewers. Results: Fifteen reports were selected from 410 identified. Descriptive studies mainly showed low bias risk, ex-perimental studies mostly an "unclear risk". Dentifrices or mouthwashes were linked to OMP, with an unknown origin in 5 subjects. Sodium lauryl-sulphate (SLS) was behind this disorder in 21 subjects, tartar-control dentifrices in 2, and flavouring agents in 1 case. Desquamation extension was linked to SLS concentration. Most cases were painless, leaving normal mucosa after desquamation. Tartar-control dentifrices caused ulcerations more frequently. Conclusions: OMP management should consider differential diagnosis with oral desquamative lesions, particularly desquamative gingivitis, with a guided clinical interview together with pathological confirmation while discouraging the use of the product responsible for OMP


No disponible


Assuntos
Humanos , Placa Dentária , Dentifrícios , Mucosa Bucal , Antissépticos Bucais , Dodecilsulfato de Sódio
5.
Acta otorrinolaringol. esp ; 70(3): 158-164, mayo-jun. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-185387

RESUMO

Introduction and objective: Oral benign neoplasms (OBNs) exhibit some features that can guide the professionals to the correct diagnosis and best treatment. Through retrospective studies, medical records can be reviewed to better describe a given population and, furthermore, help clinicians in routine practice. In this context, the objective of this paper was to analyze the cases of OBNs of an oral pathology referral department, from 2003 to 2017, in order to better understand their epidemiological and clinicopathological characteristics. Methods: A total of 8355 histopathological reports were analyzed. Lesions diagnosed as OBNs were selected and the following variables were recorded: gender, age, histological type of the lesion, anatomical location, rate and pattern of growth, type of base, color, symptomatology and diagnostic hypotheses on clinical examination. Results: OBNs represented 9.4% of all lesions diagnosed. The most frequent histopathological types were fibroma (39.9%), papilloma (22%), fibroblastoma (13.1%), lipoma (10.2%) and hemangioma (6.1%). Overall, most cases affected females (n = 518; 65.6%) and in the fifth decade of life (n = 148; 18.7%). The oral mucosa was the most common site (n = 265; 33.5%). The most common features of each OBN were also highlighted. Conclusion: The most common OBNs were fibroma, papilloma, fibroblastoma, lipoma and hemangioma. Overall, the OBN presented common clinical features; however, in particular cases, there are some characteristics that can lead the professionals to the correct diagnosis. Nevertheless, in general, histopathological analysis must be performed to confirm diagnosis. Intraosseous tumors and large lesions may require imaging tests to help diagnosis


Introducción y objetivos: Las neoplasias benignas orales (NBO) presentan características clínico-patológicas específicas que pueden guiar al profesional al diagnóstico correcto y a un mejor tratamiento. Los estudios retrospectivos son uno de los principales recursos utilizados para conocer la situación actual de una población determinada y estimar sus necesidades para la implementación y el mantenimiento de los servicios de salud. En este contexto, el objetivo de este trabajo fue analizar los casos de NBO de un servicio de referencia en patología oral, de 2003 a 2017, para comprender mejor sus características epidemiológicas y clínico-patológicas. Métodos: se analizaron un total de 8355 informes histopatológicos. Se seleccionaron las lesiones diagnosticadas como NBO y se registraron las siguientes variables: sexo, edad, tipo histológico de la lesión, ubicación anatómica, índice y patrón de crecimiento, tipo de base, color, sintomatología e hipótesis diagnósticas en el examen clínico. Resultados: Las NBO representaron el 9,4% de todas las lesiones diagnosticadas. Los tipos histopatológicos más frecuentes fueron fibroma (39,9%), papiloma (22%), fibroblastoma (13,1%), lipoma (10,2%) y hemangioma (6,1%). También fueron verificados el perfil de los pacientes y las presentaciones clínicas de estas lesiones. Conclusiones: Las NBO más comunes fueron fibroma, papiloma, fibroblastoma, lipoma y hemangioma. En general, las NBO presentaron características clínicas comunes; sin embargo, en casos particulares, existen algunas características que pueden llevar al profesional al diagnóstico correcto. Sin embargo, de forma general, el análisis histopatológico debe hacerse para confirmar el diagnóstico. Los tumores intraóseos y las lesiones de gran tamaño pueden requerir exámenes de imagen para ayudar al diagnóstico


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Bucais/patologia , Distribuição por Idade , Brasil/epidemiologia , Fibroma/epidemiologia , Fibroma/patologia , Fibrossarcoma/epidemiologia , Fibrossarcoma/patologia , Hemangioma/epidemiologia , Hemangioma/patologia , Lipoma/epidemiologia , Lipoma/patologia , Mucosa Bucal/patologia , Neoplasias Bucais/epidemiologia , Papiloma/epidemiologia , Papiloma/patologia , Estudos Retrospectivos , Distribuição por Sexo , Fatores de Tempo
6.
Gerokomos (Madr., Ed. impr.) ; 30(2): 72-75, jun. 2019.
Artigo em Espanhol | IBECS | ID: ibc-183945

RESUMO

Introducción y objetivos: El presente estudio se plantea describir las actividades a implementar para mejorar el tratamiento, tales como la prevención de lesiones orales, en especial, la micosis oral, en la población geriátrica en tratamiento con aerosolterapia. Metodología: Se ha llevado a cabo un proceso de revisión bibliográfica en diferentes bases de datos electrónicas nacionales (CUIDEN) e internacionales (Cochrane y PubMed), que se ha completado con una búsqueda manual de guías de práctica clínica y motores de búsqueda, y con una búsqueda secundaria de artículos. Se han admitido publicaciones realizadas entre enero de 2013 y marzo de 2018. Resultados: La disminución de las dosis de aerosolterapia, la correcta higiene bucodental y la adecuada limpieza de los dispositivos de aerosolterapia se encuentran como actividades para el tratamiento y la prevención de las lesiones bucales, principalmente las candidiasis orales. Conclusiones: Se considera necesario realizar estudios homogéneos y centrados en la población geriátrica, sobre todo en la prevención de estas patologías, superando las limitaciones metodológicas encontradas


Introduction and objectives: This study aims to describe the activities to implement to improve the treatment as the prevention of oral disease, especially oral mycosis, in the geriatric population with aerosol therapy. Methodology: A bibliographic review process has been carried out in different national (CUIDEN) and international (Cochrane and PubMed) electronic databases, completing it with a manual search in clinical practice guides and search engines, and with a secondary search of articles. Publications published between January 2013 and March 2018 have been accepted. Results: The reduction of aerosol therapy doses, the correct oral hygiene and the adequate cleaning of the aerosol therapy devices are found as activities for the treatment and prevention of oral lesions, mainly oral candidiasis. Conclusions: It is considered necessary to conduct homogeneous studies focused on the geriatric population, especially in the prevention of these pathologies, overcoming the methodological limitations found


Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Mucosa Bucal/patologia , Candidíase Bucal/terapia , Prevenção Primária , Candidíase Bucal/prevenção & controle , Micoses/terapia
7.
Med. oral patol. oral cir. bucal (Internet) ; 24(3): e373-e378, mayo 2019. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-185646

RESUMO

Background: The aim of this study was to describe the clinicopathological characteristics of 43 intraoral lipomas and classify them according to their microscopic variants. Material and Methods: All the cases of intraoral lipomas diagnosed at an Oral Pathology service were selected for the study. Clinical data, such as age, gender, location, time of evolution, clinical presentation, clinical hypothesis of diagnosis, and treatment, were collected from the clinical files. Results: Of the 43 cases analyzed, 24 (55.8%) occurred in women. The mean age was 77.4 years. The most affected site was the buccal mucosa (22 cases, 51.1%). The mean lesion size was 1.7 cm. Twenty-three cases (53.5%) were classified as simple lipoma, 14 (32.6%) as fibrolipoma, four (9.3%) as spindle cell/pleomorphic lipoma (SC/PL), one (2.3%) as lipoma of the salivary glands, and one (2.3%) as intramuscular lipoma. In one case of SC/PLs, lipoblasts were observed. No atypical lipoblasts or mitoses were noted. Lipoma was considered more often than other tumor histological subtypes among the clinical hypotheses of diagnosis when the final diagnosis was simple lipoma (p = 0.01). Conclusions: Intraoral lipomas present different clinical presentation depending on the histological subtype. In SC/PLs, lipoblasts with vacuolated cytoplasm may be found and the presence of mature adipocytes is essential for diagnosis


No disponible


Assuntos
Humanos , Feminino , Idoso , Lipoma , Doenças da Língua , Mucosa Bucal
8.
Cir. plást. ibero-latinoam ; 45(1): 57-66, ene.-mar. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-182679

RESUMO

Introducción y Objetivo: El colgajo FAMM (colgajo músculo-mucoso de arteria facial) descrito en 1992 por Pribaz y col, es un colgajo intraoral basado en la arteria facial, compuesto por mucosa oral, submucosa, músculo bucinador, arteria facial y por el plexo venoso correspondiente y puede ser de base inferior (flujo anterógrado) o superior (flujo retrógrado). Es un colgajo versátil que se puede usar en la reconstrucción de defectos de múltiples localizaciones (paladar, lengua o suelo de boca). Con este trabajo pretendemos demostrar su utilidad en la reconstrucción de diferentes defectos intraorales. Material y Método: Presentamos 3 casos en lo que empleamos el colgajo FAMM para reconstrucción intraoral: un paciente con anquiloglosia cicatricial secuela de carcinoma de suelo de boca, un paciente con fístula de paladar secuela de resección tumoral, y un paciente con exposición intraoral de arco mandibular por osteonecrosis secundaria a bifosfonatos. Resultados: Todos los colgajos sobrevivieron al 100% y permitieron una cobertura estable y duradera, con ausencia de complicaciones mayores. Conclusiones: El colgajo FAMM permite la reconstrucción de defectos intraorales y periorales con tejido bien vascularizado y de idénticas características a las de la zona a reconstruir, con baja morbilidad de la zona donante, lo que lo convierte en una excelente opción reconstructiva para defectos de esta región anatómica


Background and Objective: The facial artery musculo-mucosal (FAMM) flap, first described by Pribaz et al. in 1992, is an intraoral flap based on the facial artery. It is composed of mucosa, submucosa, buccinator muscle and the facial artery along with its venous plexus. The design of the flap can be inferiorly-based and rely on antegrade blood flow or superiorly-based with retrograde flow. The FAMM flap is a versatile flap that can be used for the reconstruction of defects of multiple locations (palate, lips, tongue, and floor of the mouth). The purpose of this study is to demonstrate the utility of the FAMM flap in the reconstruction of different intraoral defects. Methods: In this article the authors present 3 cases in which the FAMM flap was used for intraoral reconstruction: one patient with a history of ankyloglossia sequelae of a squamous cell carcinoma of the floor of the mouth; one patient with a palatal fistula sequelae of tumor excision; and one patient with a biphosphonate-related osteonecrosis of the mandible. Results: All flaps survived and provided a stable and reliable coverage of the defect. There were no major complications. Conclusions: The FAMM flap is a well vascularized flap that replaces like with like tissue. Because of its low morbidity, low rate of complications and reliable results, the FAMM flap is an excellent option for reconstruction of small to moderate intra-oral defects


Introdução e Objetivo: O retalho FAMM (facial artery musculo-mucosal flap), descrito em 1992 por Pribaz et al., é um retalho intra-oral baseado na artéria facial. É composto por mucosa oral, submucosa, músculo bucinador, artéria facial e pelo plexo venoso correspondente, podendo basear-se inferior (fluxo anterógrado) ou superiormente (fluxo retrógrado). É um retalho versátil que pode ser utilizado nareconstrução de defeitos em múltiplas localizações (palato, lábio, língua, pavimento da boca). Com este trabalho pretende-se demonstrar a utilidade do retalho FAMM na reconstrução de diferentes defeitos intra-orais. Material e Métodos: Os autores apresentam 3 casos em que se utilizou o retalho FAMM para reconstrução intra-oral: um doente com anquiloglossia cicatricial sequelar de carcinoma do pavimento da boca; uma doente com uma fístula do palato sequela de excisão tumoral; e um doente com exposição intra-oral do arco mandibular anterior por osteonecrose secundária a bifosfonatos. Resultados: Todos os retalhos sobreviveram a 100% e permitiram uma cobertura estável e duradoura, na ausência de complicações major. Conclusão: O retalho FAMM permite a reconstrução de defeitos intra e peri-orais com tecido bem vascularizado e de características idênticas à zona a reconstruir, com baixa morbilidade da zona dadora, o que o torna uma excelente opção reconstrutiva para defeitos desta região anatómica


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Retalhos Cirúrgicos/cirurgia , Mucosa Bucal/anormalidades , Mucosa Bucal/cirurgia , Soalho Bucal/anormalidades , Palato/anormalidades , Palato/cirurgia , Língua/anormalidades , Língua/cirurgia , Neoplasias Bucais/radioterapia , Anquiloglossia/complicações
9.
Ars pharm ; 60(1): 27-33, ene.-mar. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-182797

RESUMO

Aims: To determine the inhibitory effect of oral Lactobacillus against bacterial pathogens and investigate correlation between presence of Lactobacillus strains and health promotion. Method: One hundred saliva samples were collected from oral cavity of domestic dairy consumers and were investigated for the isolation and identification of Lactobacillus strain by conventional culture and sequencing of 16SrRNA. Furthermore, well diffusion assay was performed to determination of antibacterial activity of Lactobacillus strains against bacterial pathogens including Salmonella typhimurium, Klebsiella pneumoniae, Shigella sonnei, Shigella dysenteriae, Enterococcus faecalis and Enterococcus faecium. Finally, association between health condition and isolation of Lactobacillus were investigated and obtained data using questionary form were analysed by chi-square test. Results: Thirty Lactobacillus strains recovered from 100 hundred saliva samples. The most common isolated strain was L. gasseri (n=18) and followed by L. vaginalis (n=3) and L. salivarius (n=3). All Lactobacillus strains demonstrated antibacterial activity against at least one of the investigated pathogens. However, the strongest results were obtained by L. vaginalis against K. pneumonia. The correlation between the presence of thirty Lactobacillus strains and health promotion not found. However, only L. gasseri species has significant positive impact on health in their hosts (P < 0.05). Conclusion: Only some Lactobacillus species have a positive impact on health promotion. Despite of weak activity against the investigated pathogens, L. gasseri has a positive impact on the mental problem (intense anger and depression) of their hosts


Objetivos: Determinar el efecto inhibidor del Lactobacillus aislado de la cavidad oral contra patógenos bacterianos e investigar la correlación entre la presencia de cepas de Lactobacillus y la promoción de la salud. Método: se recolectaron cien muestras de saliva de la cavidad oral de consumidores de productos lácteos y se investigó el aislamiento e identificación de la cepa de Lactobacillus mediante cultivo convencional y secuenciación de 16SrRNA. Además, se realizó un ensayo de difusión en pocillos para determinar la actividad antibacteriana de las cepas de Lactobacillus contra patógenos bacterianos que incluyen Salmonella typhimurium, Klebsiella pneumoniae, Shigella sonnei, Shigella dysenteriae, Enterococcus faecalis y Enterococcus faecium. Finalmente, se investigó la asociación entre el estado de salud y el aislamiento de Lactobacillus y se obtuvieron los datos utilizando el cuestionario mediante la prueba de chi-cuadrado. Resultados: Se aislaron treinta cepas de Lactobacillus de 100 muestras de saliva. La cepa aislada más común fue L. gasseri (n = 18), seguida por L. vaginalis (n = 3) y L. salivarius (n = 3). Todas las cepas de Lactobacillus demostraron actividad antibacteriana contra al menos uno de los patógenos investigados Sin embargo, los resultados más fuertes fueron obtenidos por L. vaginalis contra K. pneumonia. No se encontraron correlación entre la presencia de algunas de las treinta cepas de Lactobacillus y la promoción de la salud. Sin embargo, solo la especie L. gasseri tuvo un impacto positivo significativo en la salud de sus hospedadores (P <0,05). Conclusión: solo algunas especies de Lactobacillus tienen un impacto positivo en la promoción de la salud. A pesar de la actividad débil contra los patógenos investigados, L. gasseri tiene un impacto positivo en el problema mental (ira intensa y depresión) de sus huéspedes


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Lactobacillus/química , Lactobacillus/isolamento & purificação , Mucosa Bucal/microbiologia , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Saliva/microbiologia , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
11.
Med. oral patol. oral cir. bucal (Internet) ; 23(5): e511-e517, sept. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-176367

RESUMO

Background: The aim of this study was to analyze the distribution of oral and maxillofacial lesions affecting children and adolescents patients from a single oral pathology laboratory from Rio de Janeiro, Brazil. Material and Methods: Oral and maxillofacial lesions biopsied in patients younger than 19-years were retrieved from the oral pathology files of the Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro over a 75-year period (1942-2017). The clinical data and the diagnoses of each case were included in a Microsoft Excel® database, being classified into 13 categories according to the etiology. A descriptive analysis of the variables age, gender and final diagnosis was made. Results: From 19.095 lesions diagnosed in this period, 2408 (12.61%) were from patients aged 0 to19 years, with a higher incidence in females in the second decade. Salivary gland pathology was the most common group of lesions (24.30%), followed by reactive lesions (16.82%) and odontogenic cysts (14.66%). Mucocele was the most common lesion (21.72%), followed by dentigerous cyst (6.48%) and fibrous hyperplasia (6.44%). Malignant lesions were observed in 1.12% of all cases with Burkitt lymphoma as the most frequent. Conclusions: Our results were similar to previous studies and knowledge of these data may contribute to the understanding of oral lesions that most commonly affects children


No disponible


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Doenças da Boca/epidemiologia , Doenças Dentárias/epidemiologia , Cisto Dentígero/epidemiologia , Hiperplasia Gengival/epidemiologia , Mucosa Bucal , Cistos não Odontogênicos/epidemiologia , Granuloma Periapical/epidemiologia , Prevalência , Brasil/epidemiologia , Cisto Radicular/epidemiologia , Estudos Retrospectivos
12.
Cient. dent. (Ed. impr.) ; 15(1): 15-18, ene.-abr. 2018. ilus
Artigo em Espanhol | IBECS | ID: ibc-172855

RESUMO

La sialolitiasis es la segunda patología más prevalente de las glándulas salivares, representando el 30% de la patología salival. La localización más frecuente es en la glándula submandibular, con alrededor del 80% de los casos de litiasis, mientras que la afectación de las glándulas salivares menores es de aproximadamente un 2%. La etiopatogenia de esta entidad sigue siendo un tema controvertido, sin embargo se atribuyen factores bioquímicos, infecciosos y mecánicos como los causantes de su formación. Una adecuada exploración física acompañada de la realización de pruebas complementarias de imagen, como la ecografía, resonancia magnética (RM) o tomografía computerizada (TC), serán fundamentales para el diagnóstico de la lesión. Se presenta el caso clínico de una paciente con diagnóstico de sialolitiasis de glándula salival menor labial tratada quirúrgicamente así como los resultados de la revisión científica bibliográfica hecha al respecto


Sialolithiasis is the second most frequent disease of the salivary glands, representing the 30% of whole salivary pathology. The most prevalent localization occurs in the submandibular gland, affected in 80% of cases of lithiasis, whereas minor salivary glands are concerned only in 2%. The etiology of this entity is still controversial, however different biochemical, infectious and mechanics factors have been attributed as the source of its formation. A correct physic examination along with supplementary images tests, as ultrasound, MRI or CT scan, will be essential for the right diagnosis. A case of a female diagnosed with sialolithiasis of minor salivary gland and surgically treated within a review of the literature is described


Assuntos
Humanos , Feminino , Idoso , Cálculos das Glândulas Salivares/diagnóstico , Glândulas Salivares Menores/patologia , Diagnóstico Diferencial , Mucosa Bucal/patologia , Neoplasias Labiais/patologia
13.
Med. oral patol. oral cir. bucal (Internet) ; 23(2): e138-e143, mar. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-171393

RESUMO

Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum. However, there are of hematogenic and vertical transmission. All health care professionals must be aware of the manifestations of this condition, such as oral lesions. Objectives: This study to analyze and compare four clinical cases of syphilis that were diagnosed based on lesions in the oral cavity with published literature. Material and Methods: Four patients with a confirmed sorologic and clinical diagnosis of syphilis were examined, confirmated from manifestation of oral lesions together with analysis of serological laboratory tests and histopathological analyses. Results: Lesions were found in classic sites such as lips, tongue and skin. However, there were also lesions on the hard palate, and labial commissure, which correspond to less than 5% of the syphilis oral manifestations. Conclusions: The practice of unprotected oral sex may result in infection and development of syphilis. The acknowledgment of the oral manifestations of syphilis in all its period of training for health professionals is of basic importance, the association of clinical features, histopathological findings and serological tests are required to complete the diagnosis and correct treatment (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Sífilis/diagnóstico , Sífilis/patologia , Treponema pallidum/isolamento & purificação , Treponema pallidum/patogenicidade , Boca/patologia , Infecções por Treponema/diagnóstico , Sorodiagnóstico da Sífilis/métodos , Mucosa Bucal/patologia
14.
Med. oral patol. oral cir. bucal (Internet) ; 23(2): e144-e150, mar. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-171394

RESUMO

Background: Oral white sponge nevus (WSN) is a rare autosomal dominant benign condition, characterized by asymptomatic spongy white plaques. Mutations in Keratin 4 (KRT4) and 13 (KRT13) have been shown to cause WSN. Familial cases are uncommon due to irregular penetrance. Thus, the aim of the study was: a) to demonstrate the clinical and histopathological features of a three-generation Turkish family with oral WSN b) to determine whether KRT4 or KRT13 gene mutation was the molecular basis of WSN. Material and Methods: Out of twenty members of the family ten were available for assessment. Venous blood samples from six affected and five unaffected members and 48 healthy controls were obtained for genetic mutational analysis. Polymerase chain reaction was used to amplify all exons within KRT4 and KRT13 genes. These products were sequenced and the data was examined for mutations and polymorphisms. Results: Varying presentation and severity of clinical features were observed. Analysis of the KRT13 gene revealed the sequence variant Y118D as the disease-causing mutation. One patient revealed several previously unreported polymorphisms including a novel mutation in exon 1 of the KRT13 gene and a heterozygous deletion in exon 1 of KRT4. This deletion in the KRT4 gene was found to be a common polymorphism reflecting a high allele frequency of 31.25% in the Turkish population. Conclusions: Oral WSN may manifest variable clinical features. The novel mutation found in the KRT13 gene is believed to add evidence for a mutational hotspot in the mucosal keratins. Molecular genetic analysis is required to establish correct diagnosis and appropriate genetic consultation (AU)


No disponible


Assuntos
Humanos , Masculino , Adulto , Nevo/classificação , Nevo/patologia , Leucoplasia/diagnóstico , Leucoplasia/patologia , Mucosa Bucal/patologia , Biópsia , Mutagênese/genética
15.
Med. oral patol. oral cir. bucal (Internet) ; 23(2): e151-e160, mar. 2018. tab, ilus, graf
Artigo em Inglês | IBECS | ID: ibc-171395

RESUMO

Background: Most of the studies dealing with Chronic Mechanical Irritation (CMI) and Oral Cancer (OC) only considered prosthetic and dental variables separately, and CMI functional factors are not registered. Thus, the aim of this study was to assess OC risk in individuals with dental, prosthetic and functional CMI. Also, we examined CMI presence in relation to tumor size. Material and methods: a case-control study was carried out from 2009 to 2013. Study group were squamous cell carcinoma cases; control group was patients seeking dental treatment in the same institution. Results: 153 patients were studied (Study group n=53, Control group n=100). CMI reproducibility displayed a correlation coefficient of 1 (p< 0.0001). Bivariate analysis showed statistically significant associations for all variables (age, gender, tobacco and alcohol consumption and CMI). Multivariate analysis exhibited statistical significance for age, alcohol, and CMI, but not for gender or tobacco. Relationship of CMI with tumor size showed no statistically significant differences. Conclusions: CMI could be regarded as a risk factor for oral cancer. In individuals with other OC risk factors, proper treatment of the mechanical injuring factors (dental, prosthetic and functional) could be an important measure to reduce the risk of oral cancer (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias Bucais/complicações , Neoplasias Bucais/patologia , Mucosa Bucal/patologia , Estudos de Casos e Controles , Leucoplasia Oral/complicações , Leucoplasia Oral/cirurgia , Análise Multivariada
17.
Med. oral patol. oral cir. bucal (Internet) ; 23(1): e59-e64, ene. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-170305

RESUMO

Background: In view of the many white or predominantly white lesions of the oral mucosa it is a challenge for dentists to clinically identify a leukoplakia, being a potentially (pre)malignant lesion. Material and Methods: Based on the available literature and experience of the authors the parameters of a clinical diagnosis of oral leukoplakia have been studied. Results: A guide has been presented that should help dentists to establish a clinical diagnosis of leukoplakia as accurate as possible. Conclusions: Probably in most parts of the world dentists will need the help of a specialist for confirmation or exclusion of the clinical diagnosis of oral leukoplakia and for further management of the patient, including patient information (AU)


No disponible


Assuntos
Humanos , Leucoplasia Oral/diagnóstico , Mucosa Bucal/lesões , Mucosa Bucal/patologia , Biópsia , Carcinoma in Situ/diagnóstico , Carcinoma in Situ/fisiopatologia , Candidíase/epidemiologia , Boca/lesões , Boca/patologia
18.
Med. oral patol. oral cir. bucal (Internet) ; 23(1): e78-e85, ene. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-170308

RESUMO

Background: The aim of this study is to evaluate the resection of hyperplastic lesions on the buccal mucosa comparing the 532nm laser (KTP), versus diode 980nm laser, considering pain, scarring, inflammation and drug consumption that occurred postoperatively with each lasers. Material and Methods: A prospective study of consecutive series of 20 patients in two groups that presents hyperplastic lesions on the buccal mucosa. The choice of the KTP laser or diode 980nm laser for the surgery was made randomly. The power used was 1.5W in both groups in a continuous wave mode with a 320 μm optical fiber. Parameters of pain, scarring, inflammation and consumption of drugs were recorded by a Numerical Rating Scale and evaluated postoperatively. These recordings were made the day of the surgery, 24 hours after, 14 and 28 days after. Results: Pain and inflammation was light - moderate. The consumption of paracetamol was somewhat higher in the diode 980nm laser versus the KTP laser after 24 hours, although data was not statistically significant; significant differences were found after 28 days in regards to pain (p = 0.023) and inflammation (p = 0.023), but always in the absence parameter so we find no pain in both lasers. Scarring in the two types of laser showed no differences along the visits, with not detected scar retractable. Conclusions: Although there is a slight histological difference regarding the KTP laser in the oral soft tissues for clinical use, both wavelengths are very suitable for excision of oral fibroma (AU)


No disponible


Assuntos
Humanos , Hiperplasia/diagnóstico , Hiperplasia/terapia , Neoplasias Bucais/terapia , Mucosa Bucal/patologia , Mucosa Bucal/efeitos da radiação , Terapia a Laser/métodos , Estudos Prospectivos , Acetaminofen/uso terapêutico , Manejo da Dor
19.
J. physiol. biochem ; 73(3): 465-474, ago. 2017. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-178897

RESUMO

Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help translate the knowledge of epigenetics to public health practice, the present study aims to explore the parallelism of methylation levels between white blood cells and buccal samples in relation to obesity and associated disorders. Blood and buccal swap samples were collected from a subsample of the Spanish cohort of the Food4Me study. Infinium HumanMethylation450 DNA Analysis was carried out for the determination of methylation levels. Standard deviation for Beta values method and concordance correlation analysis were used to select those CpG which showed best parallelism between samples. A total of 277 CpGs met the criteria and were selected for an enrichment analysis and a correlation analysis with anthropometrical and clinical parameters. From those selected CpGs, four presented high associations with BMI (cg01055691 in GAP43; r = -0.92 and rho = -0.84 for blood; r = -0.89 and rho = -0.83 for buccal sample), HOMA-IR (cg00095677 in ATP2A3; r = 0.82 and rho = -0.84 for blood; r = -0.8 and rho = -0.83 for buccal sample) and leptin (cg14464133 in ADARB2; r = -0.9182 and rho = -0.94 for blood; r = -0.893 and rho = -0.79 for buccal sample). These findings demonstrate the potential application of non-invasive buccal samples in the identification of surrogate epigenetic biomarkers and identify methylation sites in GAP43, ATP2A3 and ADARB2 genes as potential targets in relation to overweight management and insulin sensibility


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Metilação de DNA , Mucosa Bucal/metabolismo , Sobrepeso/metabolismo , Ilhas de CpG , Epigênese Genética , Leucócitos/metabolismo , Sobrepeso/genética
20.
Arch. esp. urol. (Ed. impr.) ; 70(4): 445-453, mayo 2017. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-163836

RESUMO

Objetivo: Realización de una revisión bibliográfica sobre el uso del injerto de mucosa oral (BMG) en el tratamiento de estenosis ureterales extensas, según los criterios de la Medicina Basada en la Evidencia. Métodos: Búsqueda en Pubmed de los estudios publicados con las siguientes palabras clave: ‘ureteral stricture treatment’, ‘buccal mucosa graft ureteral treatment’ y ‘buccal mucosa graft ureteroplasty’, sin límites de tiempo, en inglés y castellano; identificándose 12 artículos con un total de 48 casos (46 pacientes) de uso de BMG en reparación ureteral. Resultados: Las principales etiologías de estenosis ureteral donde se ha aplicado el BMG han sido las estenosis iatrogénicas e inflamatorias. Este injerto se ha utilizado sobre todo en estenosis de uréter proximal o medio, como parche según técnica onlay o como injerto tubularizado. Se han reportado complicaciones precoces y tardías del procedimiento en el 16,7% y 10,4%, respectivamente, con una tasa de reestenosis del 6,25%. Se objetiva un 91,6% de éxito con esta técnica, con un tiempo medio de seguimiento de 22 (3-85) meses. Conclusiones: Los hallazgos de la presente revisión no justifican el uso universal del BMG en todas las estenosis ureterales, particularmente en ausencia de un seguimiento a largo plazo, pero aun así proporcionan evidencia de que el BMG puede ser utilizado eficazmente en estenosis ureterales extensas (AU)


Objective: To perform a literature review on the use of buccal mucosa graft (BMG) in the treatment of extensive ureteral stenosis, according to the criteria of Evidence Based Medicine. Methods: Pubmed search of published studies with the following keywords: ‘ureteral stricture treatment’, ‘buccal mucosa graft ureteral treatment’ and ‘buccal mucosa graft ureteroplasty’, without time limits, in English and Spanish; 12 articles were identified with a total of 48 cases (46 patients) of BMG use in ureteral repair. Results: The main etiologies of ureteral stenosis, where BMG has been applied, have been iatrogenic and inflammatory strictures. This graft has been used mainly in proximal or middle ureter stenosis, as a patch according to onlay technique or as a tubularized graft. Early and late complications of the procedure have been reported in 16.7% and 10.4%, respectively, with a restenosis rate of 6.25%. A 91.6% success rate was observed with this technique, with an average follow-up time of 22 (3-85) months. Conclusions: The findings of the present review do not justify the universal use of BMG in all ureteral strictures, particularly in the absence of long-term follow-up, but still provide evidence that BMG can be effectively used in extensive ureteral strictures (AU)


Assuntos
Humanos , Estreitamento Uretral/cirurgia , Retalhos Cirúrgicos , Mucosa Bucal/transplante , Procedimentos Cirúrgicos Reconstrutivos/métodos , Doença Iatrogênica
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