Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 39
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Intervalo de ano de publicação
1.
Eur. j. anat ; 24(3): 193-203, mayo 2020. tab, ilus, graf
Artigo em Inglês | IBECS | ID: ibc-191468

RESUMO

The degenerative and inflammatory changes were reported in cardiac tissues of rats exposed to zidovudine (ZDV). This study was designed to ex-amine the histochemical changes in the myocardi-um of adult Wistar rats exposed to ZDV and ad-ministered with methanolic extract of Buchholzia coriacea (MEBC) seed. Forty-eight healthy Wistar rats weighing 150-155 g. were randomly assigned into eight groups of six rats each. Group A served as control and received distilled water; group B received 100 mg/kg of ZDV; group C received 600 mg/kg of MEBC; group D received 100 mg/kg of vitamin C; group E received 100 mg/kg of vitamin C and ZDV; group F received 150 mg/kg of MEBC and 100 mg/kg of ZDV; group G received 300 mg/kg of MEBC and 100 mg/kg of ZDV, and group H received 600 mg/kg of MEBC and 100 mg/kg of ZDV. Treatment lasted for a period of 56 days. Blood was collected separately into clean capped plain tubes for biochemical parameters. Heartswere excised, fixed in 10% formal saline and pro-cessed for histology. ZDV induced a significant increase in the serum concentration of Nitric Oxide (NO) and Cardiac Troponin I (cTnI) in the ZDV-alone group when compared to control (p < 0.05). Also, there was reduction in activity of the Glutathi-one reductase (GR) enzyme in the ZDV-alone group relative to control (P = 0.0006, F = 7.0). Distor-tion of the cross banding pattern of cardiac muscle fibres in ZDV-alone group was manifested. These effects were reversed by administration of MEBC compared to vitamin C group


No disponible


Assuntos
Animais , Ratos , Ventrículos do Coração/anatomia & histologia , Metanol/administração & dosagem , Zidovudina/efeitos adversos , Cardiotoxicidade/tratamento farmacológico , Cardiotoxicidade/veterinária , Coração/anatomia & histologia , Capparaceae , Extratos Vegetais/administração & dosagem , Ventrículos do Coração/efeitos dos fármacos , Zidovudina/administração & dosagem , Ratos Wistar/anatomia & histologia , Coração/efeitos dos fármacos , Técnicas Histológicas , Fotomicrografia , Antioxidantes/administração & dosagem , Sementes
2.
Nutr. hosp ; 36(4): 905-911, jul.-ago. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-184717

RESUMO

Introduction: therapeutic lifestyles changes including frequent consumption of legumes have resulted in improved metabolic control and decreased blood pressure in type 2 diabetes-mellitus (T2DM) patients. Objective: this was a quasi-experimental-28-week crossover-study that assessed the effect of daily consumption of the legume Lupinus mutabilis (LM) on metabolic control of T2DM patients under hypoglycemic oral treatment. Material and methods: we recruited 79 adult male and female patients that were followed for 14-weeks without LM consumption and then received increasing doses of a LM-based-snack for other 14-weeks. Results: there was a significant decrease in blood pressure and a significant increase in HDL-cholesterol by the end of the study period. While patients with A1C concentrations > 8 and ≤ 10 did not significantly improve their metabolic control, patients with serum A1C concentrations ≤ 8.0% reduced significantly their A1C after the intervention and 71% achieved a target concentration of 6.5%. Conclusion: patients with T2DM could benefit with the addition of LM-snack to their conventional treatment


Introducción: los cambios recomendados sobre los estilos de vida, incluido el consumo frecuente de leguminosas, han resultado en un mejor control metabólico y disminución de la presión arterial en pacientes con diabetes mellitus tipo 2 (DMT2). Objetivo: este fue un estudio casi experimental cruzado de 28 semanas que evaluó el efecto del consumo diario de la leguminosa Lupinus mutabilis Sweet (LM) en el control metabólico de pacientes con DMT2 con tratamiento oral hipoglucemiante. Material y métodos: inicialmente se reclutaron 79 pacientes adultos, hombres y mujeres, que fueron seguidos durante 14 semanas sin consumo de LM y luego recibieron dosis crecientes de un tentempié de LM durante otras 14 semanas. Resultados: se observó una disminución significativa en la presión arterial y un aumento significativo en el colesterol-HDL después del consumo de LM. Mientras que los pacientes con concentraciones de A1C sérica > 8 y ≤ 10 no mejoraron significativamente su control metabólico, los pacientes con concentraciones séricas de A1C ≤ 8,0% redujeron significativamente su A1C después de la intervención y el 71% de estos pacientes llegó a la meta de tratamiento ≤ 6,5%. Conclusión: los pacientes con DMT2 podrían beneficiarse con la adición de un tentempié de LM a su tratamiento convencional


Assuntos
Humanos , Masculino , Feminino , Adulto , Diabetes Mellitus Tipo 2/dietoterapia , Lupinus , Resultado do Tratamento , Fabaceae , Lanches , Fitoterapia , Valor Nutritivo , Hipoglicemiantes/administração & dosagem , HDL-Colesterol/metabolismo , Pressão Arterial/efeitos dos fármacos , Gluconeogênese , Índice Glicêmico , Equador , Antropometria , Proteínas na Dieta , Sementes
3.
Rev. esp. enferm. dig ; 111(3): 209-213, mar. 2019. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-189827

RESUMO

Objective: to evaluate the medical economics and safety of two methods for the endoscopic removal of jujube pits, one with a transparent cap combined with a stone basket and the other with a transparent cap combined with foreign body forceps. Methods: consecutive patients with a suspected jujube pit ingestion in the esophagus between January 2008 and December 2017 were enrolled into the study. Fifty-three patients who met the criteria were divided into two groups. Group A patients were treated by a transparent cap combined with a stone basket and group B patients were treated by a transparent cap combined with foreign body forceps. The following clinical data were collected: age, sex, location of jujube pits, complications, operation time, extraction success and average hospital costs. Results: a total of 53 patients who met the criteria were enrolled into the study; 29 cases in group A and 24 cases in group B. Endoscopic removal was successful in 98.1% (52/53) of the patients and the remaining 1.9% (1/53) required surgery. Severe complications were less frequent in group A than in group B (p = 0.017). Surgery time was not significantly different between the two groups (p = 0.647). The extraction success in group A was higher than in group B (p = 0.001). The medical costs including the total cost, inspection, treatment, radiation and drug cost were not significantly different between the two groups (p > 0.05 in all cases). Conclusion: endoscopic baskets are suitable for cases of jujube pit ingestion and have a higher extraction success and a lower proportion of severe complications. Surgery time was not significantly extended and the medical costs did not increase


No disponible


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Esofagoscopia/economia , Migração de Corpo Estranho/cirurgia , Ziziphus/efeitos adversos , Sementes/efeitos adversos , Esofagoscopia/métodos , Corpos Estranhos/complicações , Duração da Cirurgia , Estudos Retrospectivos , Análise Custo-Benefício , Custos de Cuidados de Saúde/estatística & dados numéricos
6.
Nutr. clín. diet. hosp ; 38(1): 128-134, 2018. tab, graf
Artigo em Português | IBECS | ID: ibc-175414

RESUMO

Introdução: O colesterol é essencial para a vida. Em excesso no sangue, deposita-se nas paredes das artérias promovendo seu estreitamento ou obstrução. Objetivos: O objetivo foi verificar o possível efeito hipocolesterolêmico da semente de linhaça. Materiais e Métodos: Utilizaram-se 30 ratos Wistar fêmeas divididos em três grupos: Controle, Hipercolesterolêmico, e Linhaça. Os parâmetros avaliados foram: ingestão hídrica; ingestão de ração; peso corporal; gordura peritoneal e níveis de colesterol; Resultados e Discussão: O grupo controle apresentou maior ingestão hídrica (57,46 ± 0,13mL) e ração (30,68 ± 1,96g) quando comparados ao hipercolesterolêmico e linhaça; Para peso corporal total, somente o controle não sofreu alteração; Em relação ao acúmulo de gordura peritoneal, o grupo hipercolesterolêmico se sobressaiu (17,06 ± 3,99g) em comparação ao linhaça e ao controle; para os níveis de colesterol sérico, o grupo controle obteve (1,14 ± 0,14g), sendo observado portanto no grupo linhaça (1,66 ± 0,16g), uma maior aproximação para o resultado do grupo controle do que do hipercolesterolêmico (2,20 ± 6,32g), resultado que nos leva a reconhecer que a linhaça surtiu efeito benéfico sobre o colesterol. Conclusão: Os resultados obtidos demonstram benefícios na utilização da semente para redução dos níveis de gordura peritoneal, peso total e colesterol


Introduction: Cholesterol is essential for life, when in excess in blood, is deposited on the artery walls promoting its narrowing or obstruction. Objectives: The objective was to verify the possible hypocholesterolemic effect of linseed. Methods: We used 30 female Wistar rats divided into three groups: control, hypercholesterolemic, and linseed. The evaluated parameters were: water intake, feed intake, body weight, peritoneal fat, and cholesterol levels; Results and Discussion: The results were: the control group had a higher fluid intake (57.46 ± 0.13ml) and feed (30.68 ± 1.96g) when compared to hypercholesterolemic and linseed; for total body weight, only the control group did not change; in relation to the accumulation of peritoneal fat, the hypercholesterolemic group stood out (17.06 ± 3.99g) compared to linseed and control; for serum cholesterol levels, the control group obtained (1.14 ± 0.14g), thus being observed in linseed group (1.66 ± 0.16g), closer to the result of the control group than the hypercholesterolemic (2.20 ± 6.32g), a result that leads us to recognize that linseed has had a beneficial effect on cholesterol.Conclusion: The results obtained demonstrate benefits in the use of the seed to reduce levels of peritoneal fat, total weight and cholesterol


No disponible


Assuntos
Animais , Ratos , Linho , Sementes , Anticolesterolemiantes/análise , Hipercolesterolemia/dietoterapia , Sobrepeso/dietoterapia , Modelos Animais de Doenças , Estudos de Casos e Controles , Ingestão de Líquidos , Leptina , Arginina/farmacocinética , Glutamina/farmacocinética , Histidina/farmacocinética
11.
Rev. toxicol ; 35(2): 112-118, 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-176873

RESUMO

Los fármacos son considerados dentro de los llamados contaminantes emergentes, por lo que es importante investigar los efectos tóxicos que pueden producir en el medio ambiente. Este estudio tuvo como objetivos determinar el efecto tóxico de soluciones acuosas de ibuprofeno sobre un organismo acuático Artemia salina y las semillas de Allium schoenoprasum L y Lactuca sativa. Los ensayos de toxicidad se llevaron a cabo exponiendo a los organismos de prueba a concentraciones de soluciones acuosas de ibuprofeno de 20, 10, 5, 2, 1 y 0.5 mgL-1. Se determinó el porcentaje de mortalidad para la Artemia salina y la elongación de la radícula e hipocótilo para las semillas. El porcentaje de mortalidad más elevado se presentó a la concentración de 20 mgL-1, la CL50 calculada fue de 17.386 mgL-1. Un efecto tóxico bajo se presentó en la germinación de las semillas de Allium schoenoprasum L. Se produjo la inhibición en la elongación de la radícula e hipocótilo en semillas de Allium schoenoprasum L y un efecto de estimulación en la elongación de la radícula e hipocótilo de las semillas de Lactuca sativa. El mayor efecto de inhibición se presentó a 1 y 20 mgL-1 y la mayor estimulación a 20 mgL-1


Drugs are considered within the so-called emerging pollutants, so it is important to investigate the toxic effects they can produce in the environment. The aim of this study was to determine the toxic effect of aqueous solutions of ibuprofen on an aquatic organism Artemia salina and the seeds of Allium schoenoprasum L and Lactuca sativa. The toxicity tests were carried out by exposing the test organisms to concentrations of aqueous ibuprofen solutions of 20, 10, 5, 2, 1 and 0.5 mgL-1. The percentage of mortality for Artemia salina and the elongation of the radicle and hypocotyl for the seeds were determined. The highest mortality percentage occurred at the concentration of 20 mgL-1, the calculated LC50 was 17.386 mgL-1. A low toxic effect was present in the germination of the seeds of Allium schoenoprasum L. There was inhibition in the elongation of the radicle and hypocotyl in seeds of Allium schoenoprasum L and a stimulation effect in the elongation of the radicle and hypocotyl of the seeds of Lactuca sativa. The highest inhibition effect was presented at 1 and 20mgL-1 and the highest stimulation at 20 mgL-1


Assuntos
Ibuprofeno/toxicidade , Artemia , Cebolinha-Francesa , Alface , Testes de Toxicidade/métodos , Bioensaio/estatística & dados numéricos , Sementes/crescimento & desenvolvimento , Sementes
12.
Nutr. hosp ; 33(2): 386-394, mar.-abr. 2016. tab
Artigo em Inglês | IBECS | ID: ibc-153317

RESUMO

Introduction: A vegan diet can meet nutritional requirements if it is well planned. In this sense, vegans should be advised to choose alternatives to animal products and to select the appropriate respective serving size of them. The nutritional value of traditional plant foods portions is well known, however, the vegetarian market offers other products whose chemical composition is less known, as they are not widely consumed by the population. It is necessary to know both, the nutrient content of portions of these foods, and bioavailability of these nutrients in plant food diets. Objectives: This work aims to refine the available information about the nutritional contribution to the diet of a healthy adult of the main common vegan foods portions. In addition, some points about bioavailability of the most relevant nutrients are discussed, and alternatives proposed to improve nutrient utilization. Methods: Composition data of common vegan foods per 100 g were searched from food composition database, and serving size nutrient composition was calculated. Nutritional data were compared to European dietary reference values for nutrient intakes for adult population, and bioavailability of the most important nutrients was discussed (AU)


Introducción: una dieta vegetariana puede satisfacer las necesidades nutricionales si está bien planificada. En este sentido, los vegetarianos deben ser aconsejados para elegir alimentos alternativos a los productos de origen animal seleccionando el tamaño de porción adecuada de cada uno de ellos. El valor nutricional de las porciones de los alimentos vegetales tradicionales es bien conocido, sin embargo, el mercado vegetariano ofrece otros productos cuya composición química es menos conocida, ya que no son alimentos ampliamente consumidos por la población. Es necesario conocer tanto el contenido de nutrientes de las porciones de estos alimentos como la biodisponibilidad de estos nutrientes en la dieta vegetariana. Objetivos: este trabajo tiene como objetivo mejorar la información disponible sobre el aporte nutricional a la dieta de un adulto sano de las porciones de alimentos utilizados por la población vegetariana. Además, se discuten algunos puntos sobre la biodisponibilidad de los nutrientes más relevantes, y se proponen alternativas para mejorar su utilización. Métodos: los datos de composición de los alimentos veganos, por 100 g, se buscaron en bases de datos de composición de alimentos, y a partir de ellos se calculó la composición química de las porciones. Después, estos datos nutricionales se compararon con las ingestas dietéticas de referencia europeas para la población adulta, y se discutió la biodisponibilidad de los nutrientes más importantes (AU)


Assuntos
Humanos , Masculino , Feminino , Dieta Vegetariana/estatística & dados numéricos , Nutrientes/análise , Qualidade dos Alimentos , Análise de Alimentos , Recomendações Nutricionais , Necessidades Nutricionais , Disponibilidade Biológica , Proteínas de Vegetais Comestíveis/análise , Sementes , Óleos Vegetais/análise
13.
Nutr. hosp ; 33(1): 118-122, ene.-feb. 2016. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-153046

RESUMO

Objective: We evaluated the protective activity of an extract from a by-product such as olive stones, through its ability to inhibit H2 02 induced apoptosis in the SH-SY5Y human neuroblastoma cell line. Material and methods: To such end, 20,000 cells/well were cultivated and differentiation with retinoic acid was initiated. Once the cells were differentiated, apoptosis was induced with and without H2 O2 extract. Finally, cDNA extraction was performed, and pro-apoptotic genes Bax and anti-apoptotic genes Bcl-2 were analyzed. Quantification of the gene expression was performed using the GAPDH gene marker. Results: Cell viability with the extract is 97.6% (SD 5.7) with 10 mg/l and 62.8% (SD 1.2) to 50 mg/l, using 10 mg/l for the biomarker assay. The retinoic acid differentiated SH-S cell line (10 µM) shows a clear apoptosis when treated with H2 O2 150 µM, with a Bax/Bcl-2 ratio of 3.75 (SD 0.80) in contrast to the differentiated control cells subjected to H2 O2 and with extract, which have the same ratio of 1.02 (SD 0.01-0.03). Conclusion: The olive stone extract shows anti-apoptotic activity in the provoked cell death of SH-SY5Y human neuroblastoma cells in their normal state, defending them from oxidative stress which produces a significant increase in the apoptotic gene ratio in contrast to anti-apoptotic genes (Bax/Bcl-2) (AU)


Objetivo: evaluar la actividad protectora del extracto de un subproducto como son los huesos de aceitunas, mediante su capacidad de inhibir la apoptosis en la línea celular humana de neuroblastoma SH-SY5Y inducida con H2 O2 . Material y métodos: se han cultivado 20.000 cel/pocillo, iniciando diferenciación con ácido retinoico y, una vez diferenciadas las células, se ha inducido la apoptosis con H2 O2 con extracto y sin presencia del mismo. Finalmente se efectúa la extracción de cDNA y el análisis de los genes proapoptótico Bax y antiapoptótico Bcl-2. La cuantificación de la expresión génica se realiza frente al gen marcador GAPDH. Resultados: la viabilidad celular con el extracto es del 97,6% (SD 5,7) con 10 mg/l y 62,8% (SD 1,2) a 50 mg/l, utilizando 10 mg/l para el ensayo de biomarcadores. Las células de la línea SH-S diferenciadas con ácido retinoico (10 µM), muestran una clara apoptosis al ser tratadas con H2 O2 150 µM, con una relación Bax/Bcl2 de 3,75 (SD 0,80) frente a las células diferenciadas control y sometidas a H2 O2 y con extracto que tienen la misma relación de 1,02 (SD 0,01-0,03). Conclusión: el extracto de huesos de aceitunas presenta una actividad antiapoptótica frente a la provocación de la muerte celular por peróxido de hidrógeno, preservando a las células de neuroblastoma humano SH-SY5Y en su estado de normalidad, al defenderlas del estrés oxidativo que produce un significativo aumento de la relación de genes apoptóticos frente a antiapoptóticos (Bax/Bcl2) (AU)


Assuntos
Humanos , Masculino , Feminino , Neuroblastoma/dietoterapia , Polifenóis/farmacocinética , Apoptose , Estresse Oxidativo , Olea , Sementes , Substâncias Protetoras/farmacocinética , Células Neoplásicas Circulantes
14.
Rev. toxicol ; 33(1): 59-66, 2016. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-182957

RESUMO

En los últimos años existe una creciente preocupación por los efectos que los desechos de los medicamentos producen en el medio ambiente. El objetivo de esta investigación fue evaluar la ecotoxicidad aguda de antibacterianos en Lactuca sativa que se vierten a uno de los dos ríos que atraviesan las zonas más urbanizadas de la ciudad de Santa Clara (Cuba). Para esto se realizó un estudio de consumo de los antibacterianos consumidos en el hospital durante un año, se predijo sus concentraciones ambientales mediante un modelo matemático y se determinó su riesgo ecotoxicológico. En el período de estudio se utilizaron 22 antibacterianos, el de mayor consumo fue la ceftriaxona y el de menor la doxiciclina. Todos constituyen un riesgo para el ambiente exceptuando doxiciclina y miconazol. Se observó inhibición de la germinación de Lactuca sativa L. en todos los antibacterianos resaltando el cotrimoxazol con 38.78% (CI50=0.52g/L) y vancomicina la de menor efecto en la inhibición de la germinación con un 8.56% (CI50=44,14g/L). En la mezcla solamente hubo inhibición de la geminación a la mayor concentración evaluada, mientras que en el resto de las concentraciones no se evidenciaron diferencias estadísticamente significativas con respecto al control. El tipo de interacción de la mezcla se clasifica como sinérgica. El vertimiento de residuos de antibacterianos puede ser causa de contaminación ambiental perjudicial


In recent years there is growing concern about the effects that drugs produce waste in the environment. The objective of this research was to evaluate the acute ecotoxicity of antibacterials in Lactuca sativa discharged into one of two rivers that cross the most urbanized areas of the city of Santa Clara (Cuba). For this, a consumer study of antibacterial consumed in the hospital for a year was made, its environmental concentrations predicted by a mathematical model and determined their ecotoxicological risk. In the study period 22 antibacterials were used, the highest consumption was lower ceftriaxone and doxycycline. All pose a risk to the environment except doxycycline and miconazole. inhibition of germination of Lactuca sativa L. was observed in all antibacterial highlighting cotrimoxazole with 38.78% (IC50 = 0.52g / L) and vancomycin the least effect on the inhibition of germination with 8.56% (IC50 = 44,14g / L). In the mixture there was only germination inhibition at the highest concentration tested, while in other concentrations no statistically significant differences were found with respect to control. The type of interaction is classified as synergistic mixture. Shedding of antibiotics residues can cause harmful environmental pollution. while in other concentrations were not statistically significantly different from control is evidenced. The type of interaction is classified as synergistic mixture. Shedding of antibiotics residues can cause harmful environmental pollution. while in other concentrations were not statistically significantly different from control is evidenced. The type of interaction is classified as synergistic mixture. Shedding of antibiotics residues can cause harmful environmental pollution


Assuntos
Ecotoxicologia/métodos , Antibacterianos/isolamento & purificação , Poluentes Químicos da Água/análise , Sementes/toxicidade , Alface/toxicidade , Poluição Ambiental/efeitos adversos , Ceftriaxona/isolamento & purificação
15.
Nutr. hosp ; 32(5): 1909-1918, nov. 2015. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-145515

RESUMO

Introduction: chia is a seed rich in such nutrients as proteins, n-3 fatty acids and especially alpha-linolenic acid (ALA), minerals, fibers and antioxidants. Efforts have been made to assess whether human consumption of chia can reduce cardiovascular risk factors; however, it has not been established as effective and the findings of the few studies to have looked into the matter are inconsistent. Aim: to systematize the findings of studies assessing the effect the consumption of chia seed, either milled or whole, has in the prevention/control of cardiovascular risk factors in humans. Methods: this is a systematic literature review (SLR) with no meta-analysis. The articles scrutinizedwere identified in the electronic databases Lilacs, Medline (PubMed version), Cochrane, Scielo, Scopus, and Web of Science under the keywords 'dyslipidemia' or 'dislipidemia', 'hyperlipidemia' or 'hiperlipidemia', 'obesity' or 'obesidade', 'salvia' or 'salviahispanica', 'Lamiaceae' or 'chia', 'hypertension' or 'hipertensão', 'hypertrygliceridemia' or 'hipertrigliceridemia', and 'riscocardiovascular' or 'cardiovascularrisk.' We chose for our selection English-, Portuguese- or Spanish-language articles about clinical trials on humans and published within the last ten years. The biases of risk analysis were carried out considering 6 of the 8 criteria of the Cochrane Handbook for Systematic Reviews of Interventions Version 5.1. Findings: seven studies (n=200) fit our inclusion criteria. Of the chosen clinical trials, only one was not randomized. Five of the studies were blind experiments. Two of the studies were acute trials, both of them randomized. Of the chia seed interventions, one study showed a significant drop in systolic blood pressure (SBP) and inflammatory markers, yet there was no change in body mass, lipid profile or blood sugar. In four of the studies reviewed there was a significant spike in ALA and eicosapentaenoic acid (EPA), with no significant change to other parameters. In the acute trials, post-prandial blood sugar was significantly lower. Only one study showed a significant drop in triglycerides (TG), body mass and inflammatory markers; however, the chia seed in that case was mixed with other foods. Most of the studies showed unclear or low risk of bias. Two studies showed a high risk of bias because not all the pre-specified primary outcomes were reported in the findings. Conclusion: most of the studies did not demonstrate statistically significant results in relation to cardiovascular disease (CVD) risk factors. The evidence regarding the relationship between chia seed consumption and cardiovascular risk factors are insufficient, and the studies included in this review present numerous limitations. Further research is hence needed (AU)


Introducción: la chía es una semilla rica en nutrientes tales como proteínas; ácidos grasos omega 3, especialmente ácido alfa-linolénico (ALA); minerales; fibras y antioxidantes. Se han hecho esfuerzos para evaluar si el consumo humano de chía puede reducir los factores de riesgo cardiovascular; sin embargo, no se ha establecido como eficaz y los resultados de los pocos estudios que han examinado la cuestión son incompatibles. Objetivo: sistematizar los hallazgos de los estudios que evaluaron el efecto del consumo de la semilla de chía, ya sea molida o entera, tiene en la prevención/control de los factores de riesgo cardiovascular en los seres humanos. Métodos: se trata de una revisión sistemática de la literatura (SLR), sin metaanálisis. Los artículos escrutados eran identificados en las bases de datos Lilacs electrónicos, Medline (PubMed versión), Cochrane, Scielo, Scopus y Web of Science bajo la palabra clave 'dyslipidemia' o 'dislipidemia', 'hyperlipidemia' o 'hiperlipidemia', 'obesity' o 'obesidade', 'salvia' o 'salviahispanica', 'Lamiaceae' o 'chia', 'hypertension' o 'hipertensão', 'hypertrygliceridemia' o 'hipertrigliceridemia' y 'riscocardiovascular' o 'cardiovascularrisk'. Elegimos para nuestra selección artículos en inglés, portugues o español sobre ensayos clínicos en seres humanos publicados en los últimos diez años. Los sesgos de análisis de riesgo se realizaron considerando seis de los ocho criterios del Manual Cochrane para Revisiones Sistemáticas de Intervenciones Versión 5.1. Resultados: siete estudios (n = 200) encajan con los criterios de inclusión. De los ensayos clínicos seleccionados, solo uno no fue aleatorio. Cinco de los estudios fueron experimentos ciegos. Dos de los estudios eran ensayos agudos, ambos asignados al azar. De las intervenciones de semillas de chía, un estudio mostró una disminución significativa de la presión arterial sistólica (PAS) y los marcadores de inflamación; sin embargo, no hubo cambios en la masa corporal, el perfil de lípidos o el azúcar en sangre. En cuatro de los estudios revisados no había un pico significativo en ALA y ácido eicosapentaenoico (EPA), ni ningún cambio significativo en otros parámetros. En los ensayos agudos, el nivel postprandial de azúcar en sangre fue significativamente menor. Solo un estudio mostró un descenso significativo de los triglicéridos (TG), la masa corporal y los marcadores inflamatorios; sin embargo, la semilla de chía en ese caso se mezcló con otros alimentos. La mayoría de los estudios mostraron riesgos claros o bajo sesgo. Dos estudios mostraron un alto riesgo de sesgo, porque no todos los resultados primarios preespecificados fueron reportados en los hallazgos. Conclusión: la mayoría de los estudios no demostraron resultados estadísticamente significativos en relación con los factores de riesgo cardiovascular (ECV). La evidencia sobre la relación entre el consumo de semillas de chía y los factores de riesgo cardiovascular son insuficientes, y los estudios incluidos en esta revisión presentan numerosas limitaciones. Por lo tanto, se necesita más investigación (AU)


Assuntos
Humanos , Salvia , Doenças Cardiovasculares/prevenção & controle , Sementes , Extratos Vegetais/farmacocinética , Obesidade/prevenção & controle , Lamiaceae , Substâncias Protetoras/farmacocinética , Fatores de Risco , Dislipidemias/prevenção & controle , Hipertrigliceridemia/prevenção & controle , Hipertensão/prevenção & controle
16.
Nutr. hosp ; 31(3): 1176-1182, mar. 2015. tab
Artigo em Inglês | IBECS | ID: ibc-134414

RESUMO

Introduction: chia (Salvia hispanica L.) has an elevated concentration of dietary fiber, it has been used to weight loss and enhance blood glucose and lipid profile. However, data in human are still scarce or do not exist, according to the analyzed variable. Aim: to evaluate the effect of chia supplementation in body composition, lipid profile and blood glucose in overweight or obese individuals. Methods: men and women were randomly allocated in groups that ingested 35g of chia flour/day (CHIA; n=19;48.8±1.8 years) or placebo (PLA; n=7; 51.4±3.1 years) for12 weeks. Body composition and food intake were evaluated in each four weeks. Lipid profile and blood glucose were measured in the beginning and in the end of the study. Results: Chia induced significant intragroup reduction in body weight (-1.1±0.4kg; p<0.05), with a greater reduction among obese than overweighed individuals (-1.6±0.4kg; p<0.00), but without difference when compared to PLA. Waist circumference reduced 1.9±0.6 cmin CHIA group (p <0.05), but only intragroup. It was observed a reduction in total cholesterol (p=0.04) and VLDL-c (p=0.03), and an increase in HDL-c (p=0.01) but only in the groups that ingested chia flour and presented abnormal initial values. Triglycerides, blood glucose and LDL-C showed no changes for either group. Conclusion: consumption of chia for 12 weeks promotes significant but discrete reduction in weight and waist circumference, and enhances lipid profile dependent of initial values (AU)


Introducción: Debido al alto contenido de fibra dietética, la chía (Salvia hispánica L.) han sido propuesta para la pérdida de peso y mejora del perfil lipídico y glucémico. Pero los datos en humanos son escasos o inexistentes, en función de la variable analizada. Objetivo: Evaluar el efecto de la suplementación con harina de chía en la composición corporal, perfil lipídico y glucémico de individuos con sobrepeso y obesidad. Métodos: hombres y mujeres fueron asignados aleatoriamente en grupos que consumieron 35 g / día de chía (CHIA; n = 19; 48.8 ± 1.8 años) o placebo (PLA; n = 7; 51.4 ± 3.1 años) durante 12 semanas. La composición corporal y el consumo de alimentos fueron evaluados la cada cuatro semanas de intervención. Perfil lipídico y los niveles de glucosa se midieron al principio y al final del estudio. Resultados: La chía promovió reducción significativa en el peso corporal (-1.1kg; p <0.05) con la mayor reducción entre los obesos (-1.9kg; p <0.00), mientras que el grupo PLA tenía ningún cambio. Circunferencia de la cintura disminuyó en 1,9 cm en el grupo CHIA (p <0.05), pero sólo intragrupo. Fue observada una disminución en el colesterol total (p = 0.04) y VLDL-c (P = 0.03) y el aumento de los niveles de HDL-c (p = 0.01), pero sólo en el grupo que consumió la chía y tenía valores anormales al inicio del estudio. Los niveles de triglicéridos, glucosa y LDL-c no mostraron cambios en ninguno de los grupos. Conclusión: El consumo de chía durante 12 semanas reduce el peso corporal y la circunferencia de la cintura de manera significativa, pero clínicamente discreto. Chía promueve la mejora del perfil lipídico, pero estos efectos son dependientes de los valores iniciales de los grupos (AU)


Assuntos
Humanos , Sementes , Salvia , Fitoterapia , Perda de Peso , Sobrepeso/dietoterapia , Hipercolesterolemia/dietoterapia , Composição Corporal , Resultado do Tratamento
20.
Nutr. hosp ; 30(4): 825-830, oct. 2014. tab
Artigo em Inglês | IBECS | ID: ibc-134912

RESUMO

Background: The chronic use of steroid hormones can lead to alterations in the lipid profile such as an increase in LDL and decrease in HDL levels . The effect of flaxseed on lipid profiles has been widely investigated. Aim: Evaluate the lipid profile of adult male Wistar rats fed with flax based meals and submitted to androgenic hyperstimulation. Material and Methods: Forty Wistar rats were divided into 4 groups of 10 animals: the Control group (CG); Flax group (FG) fed a flaxseed flour-based meal; Induced group (IG); and the Induced group (IGF) that was fed a flaxseed flour-based meal. The induction was done by using silicone pellets filled with testosterone propionate (1mg), sealed with a surgical adhesive and substituted every 4 weeks. Results: Triglycerides (FG: 71.16 ± 21.95; IG: 99.16 ± 26.00 and IGF: 86.33 ± 27.16 mg/dL) and HDL-cholesterol (FG: 23.05 ± 1.67; IG: 29.06 ± 7.24 and IGF: 26.06 ± 3.56 mg/dL) were significantly lower in the experimental groups. The FG and IGF (41.16 ± 3.97 and 49.66 ± 11.25 mg/dL, respectively) showed significantly lower levels of cholesterol than the other groups(CG: 78,85 ± 11.58 and IG: 70,83 ± 14.85 mg/dL). Regarding LDL levels, the IG showed significantly higher concentrations (21,93 ± 8,84 mg/dL) than the others groups (CG: 7,81 ± 5,37; FG: 3,88 ± 1,32 and IGF: 6,66 ± 7,24 mg/dL). Conclusions: The flaxseed has a relevant effect on the lipid profile of animals submitted to androgenic hyperstimulation (AU)


Introducción: El uso crónico de hormonas esteroides puede causar alteraciones en el perfil lipídico como el aumento de las LDL y reducción de las HDL. Los efectos de la linaza en el perfil lipídico han sido extensivamente investigados. Objetivo: Evaluar el perfil lipídico de ratas Wistar machos adultos alimentados con piensos a base de linaza y sometidos a hiperestimulaciones androgénicas. Materiales y Métodos: Cuarenta ratas Wistar fueron divididos en 4 grupos de 10 animales: Grupo control (GC); Grupo de linaza (GL), alimentados con piensos a base de harina de linaza ; Grupo Inducido (GI); y Grupo Inducido (GIL) alimentados con piensos a base de harina de linaza. La inducción fue realizada utilizando pellets de silicona rellenados con propionato de testosterona (1 mg) cerrados con un adhesivo quirúrgico y sustituidos cada 4 semanas. Resultados: Los triglicéridos (GL: 71.16 ± 21.95; GI: 99.16 ± 26.00; GIL: 86.33 ± 27.16 mg/dL) y colesterol-HDL (GL: 23.05 ± 1.67; GI: 29.06 ± 7.24; GIL: 26.06 ± 3.56 mg/dL) estaban significativamente más bajos en los grupos experimentales. EL GL (41.16 ± 3.97 mg/dL) y GIL (49.66 ± 11.25 mg/dL) presentaron niveles menores de colesterol que los otros grupos (GC: 78,85 ± 11.58; GI: 70,83 ± 14.85 mg/dL) y el GI concentraciones significativamente mayores de LDL (21,93 ± 8,84 mg/dL) que los otros grupos (GC: 7,81 ± 5,37; GL: 3,88 ± 1,32; GIL: 6,66 ± 7,24 mg/dL). Conclusión: La linaza presenta efectos relevantes en el perfil lipídico de animales sometidos a hiperestimulaciones androgénicas (AU)


Assuntos
Animais , Ratos , Hormônios Esteroides Gonadais/farmacocinética , Linho , Sementes , Extratos Vegetais/farmacocinética , Metabolismo dos Lipídeos , Colesterol/sangue , Substâncias Protetoras/farmacocinética , Estudos de Casos e Controles
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA