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1.
Allergol. immunopatol ; 47(6): 544-550, nov.-dic. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186546

RESUMO

Introduction and objectives: Cow's milk allergy (CMA) is common, especially in children. The treatment is based on the exclusion of milk and dairy products and guidance regarding the exclusion diet. This study aimed to compare the anthropometric measurements and food intake of children with CMA with those of healthy controls, and to evaluate the serum concentrations of Vitamin A and 25(OH)D in children with CMA. Methods: This is a cross-sectional study with 27 children in the CMA group and 30 in the control group. z-Scores of body mass index and height, skinfolds, food intake and serum concentrations of retinol, beta-carotene, lycopene, 25(OH)D, parathyroid hormone and high sensitivity C-reactive protein were evaluated. Results: Mean age was four years (± 1.9). The CMA group evidenced a lower height compared to those from the control group (p = 0.0043). The CMA group showed a lower intake of calcium (p = 0.0033) and lipids (p = 0.0123). Low serum concentrations of retinol, beta-carotene, lycopene, 25(OH)D were found in 25.9%, 59.3%, 48.1% and 70.3% of the CMA group, respectively. Conclusions: Children with CMA consume smaller amounts of calcium and lipids and have shorter height compared to healthy controls. Insufficient levels of vitamins A and D were frequent in the CMA group, emphasizing the need for nutritional guidance and monitoring


No disponible


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Estado Nutricional/imunologia , Consumo de Alimentos , Hipersensibilidade a Leite/imunologia , Nutrientes/uso terapêutico , Bovinos , Vitamina A , Antropometria , Estudos Transversais , Vitamina D , Inquéritos e Questionários , Análise de Variância
2.
Med. oral patol. oral cir. bucal (Internet) ; 24(5): e636-e642, sept. 2019. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-185682

RESUMO

Background: Assess the reliability (by means of reproducibility and repeatability) of the PenguinRFA system, analyse the ISQ values of different implant types and correlate the ISQ with the insertion torque during the placement of the implant. Material and Methods: 120 rough surface implants were placed in bovine bone (type II and III). The implants were divided into groups, according to its design. Once the implants were in place, the exact insertion torque was registered. Then, primary stability was measured by means of the resonance frequency analysis with the PenguinRFA and the Osstell ISQ devices. In each implant two transducers of each device were used. Three measurements were obtained with each transducer. Results: The mean ISQ (implant stability quotient) of the whole sample is 67,70 ± 5,51. The Intraclass Correlation Coefficient (ICC) is 0,933 and 0,944 for transducers 1 and 2 respectively. The reproducibility is 0,906. The mean insertion torque is 24,54 ± 8,96N. The correlation between the ISQ and the insertion torque is 0,507 p < 0,000 (MultiPeg 1) and 0,468 p < 0,000 (MultiPeg 2) for bone type II and 0,533 p < 0,801 (MultiPeg 1) and 0,193 p < 0,140 (MultiPeg 2) for bone type III


No disponible


Assuntos
Animais , Bovinos , Implantes Dentários , Implantação Dentária Endo-Óssea , Planejamento de Prótese Dentária , Retenção em Prótese Dentária , Reprodutibilidade dos Testes , Análise de Frequência de Ressonância , Torque , Vibração
4.
Nutr. hosp ; 36(extr.1): 65-67, jun. 2019.
Artigo em Espanhol | IBECS | ID: ibc-184949

RESUMO

Objetivos: revisar los conocimientos sobre la situación nutricional de la población aragonesa y sobre la gastronomía propia de Aragón como elementos necesarios para el bienestar y la salud de la población. Métodos: búsqueda bibliográfica en relación con el tema. Resultados: se identifica una gastronomía propia de Aragón relacionada con la evolución histórica de la población en el territorio. Actualmente, la población tiende a concentrarse en centros urbanos y capitales de provincia, especialmente en Zaragoza, donde la tradición alimentaria tiende a diluirse por influencias externas. Por parte de las autoridades se impulsan los alimentos de calidad con las certificaciones IGP tanto en vinos y aceites como en hortalizas y carnes. Los aragoneses se encuentran en el quinto lugar en consumo de alimentos por habitante de España, con el mayor consumo de patatas y hortalizas frescas. También tienen un elevado consumo de carnes y son quienes poseen un mayor aporte energético proveniente de lípidos de todas las comunidades autónomas. Estos datos estarían relacionados con que la mayoría de los varones adultos tienen sobrepeso u obesidad. Conclusiones: se echan en falta estudios más actualizados que valoren la situación nutricional de la población en Aragón. El último ha sido promovido por la Vocalía Nacional del Consejo General de Colegios Farmacéuticos (CGCOF) a nivel nacional para adultos que realizan actividad física. Debe mejorarse la educación nutricional de la población a fin de que sean capaces de elegir raciones y alimentos que promocionen su salud y bienestar e integren la gastronomía tradicional en su alimentación cotidiana como parte de su patrimonio cultural


Objectives: review the knowledge on the nutritional situation of the Aragonese population and on Aragón’s own gastronomy as necessary elements for the welfare and health of its population. Methods: literature review in relation to the subject. Results: a gastronomy characteristic of Aragón is identified. The main finding identified on the literature review is to do with the historical evolution of the population in the Aragonese territory. At present, the population tends to concentrate in provincial urban centers, mainly in Zaragoza, where the food tradition tends to be diluted by external influences. The health authorities qualify quality foods by PGI (Protected Geographical Indication) certifications in wines and oils, as well as vegetables and meats. Aragón is the fifth county in food consumption per inhabitant in Spain with the highest consumption of potatoes and fresh vegetables from Spain. Meat consumption is high and are those who have a greater energy intake from lipids of all the autonomous communities. These data are related to the fact that most men are overweight or obese. Conclusions: there is a lack of updated studies that assess the nutritional status of the population in Aragón. The last study was promoted by the National Pharmacists Vocalic of Nutrition of the CGCOF (General Council of Pharmaceutical Associations of Spain) throughout Spain for adults who perform some kind of physical activity. The nutritional education of the population must be improved so that they are able to choose rations and foods that promote their health and well-being and integrate traditional gastronomy into their daily diet as part of their cultural heritage


Assuntos
Humanos , Animais , Masculino , Feminino , Bovinos , Dieta/normas , Preferências Alimentares , Estado Nutricional , Dieta/tendências , Gorduras na Dieta/administração & dosagem , Consumo de Energia , Gorduras Insaturadas na Dieta/normas , Sobrepeso/epidemiologia , Espanha/epidemiologia , Exercício Físico , Abastecimento de Alimentos , Frutas , Culinária/normas , Carne , Densidade Demográfica , Fatores Sexuais , Vinho/normas
5.
Nutr. hosp ; 36(extr.1): 98-101, jun. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-184954

RESUMO

Objetivos: el objetivo de este trabajo es estudiar las bases de la gastronomía de las Islas Baleares y buscar los patrones de alimentación, así como los perfiles nutricionales y sanitarios actuales. Métodos: búsqueda bibliográfica sobre la gastronomía y nutrición de las Islas Baleares. Resultados: el modelo gastronómico tradicional de las Islas Baleares es rico y variado y cuenta con productos de calidad reconocida bajo sellos europeos y nacionales. En la actualidad, el consumo de cereales, huevos, verduras y hortalizas, frutas, legumbres, carnes, pescados y mariscos es menor que el observado para la media nacional. Sin embargo, el consumo de bebidas alcohólicas y no alcohólicas es muy superior a esta media. Conclusiones: el consumo de alimentos actual está muy alejado del modelo mediterráneo tradicional. El perfil nutricional y sanitario es preocupante. El reto de la gastronomía balear es aunar la tradición con el saber actual para conseguir una evolución nutricionalmente aceptable y saludable


Objectives: the objective of this work was to study the basis of the gastronomy of the Balearic Islands and to look for the feeding patterns as well as the current nutritional and health profiles. Methods: bibliographic search on Balearic gastronomy and nutrition. Results: the traditional gastronomic model of the Balearic Islands is rich and varied and has products of recognized quality under European and national labels. Currently, the consumption of cereals, eggs, vegetables, fruits, pulses, meats, fish and seafood is lower than that observed for the national average. However, the consumption of alcoholic and non-alcoholic beverages is much higher than this average. Conclusions: current food consumption is very far from the traditional Mediterranean model. The nutritional and health profile is worrisome. The challenge of Balearic gastronomy is to combine tradition with current knowledge to achieve a nutritionally acceptable and healthy evolution


Assuntos
Humanos , Animais , Bovinos , Bebidas/provisão & distribução , Dieta/normas , Manipulação de Alimentos/normas , Preferências Alimentares , Nível de Saúde , Estado Nutricional , Ovos , Peixes , Frutas , Carne , Produtos Pesqueiros , Espanha , Verduras
6.
Nutr. hosp ; 36(extr.1): 110-114, jun. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-184957

RESUMO

Objetivos: la nutrición y la gastronomía forman parte de las estrategias de mantenimiento y promoción de la salud de una población. Profundizar en el conocimiento de la gastronomía y de la problemática nutricional de la Comunidad de Madrid constituye el objeto de la presente revisión. Métodos: búsqueda bibliográfica relacionada con el tema. Resultados: la gastronomía de Madrid destaca por la gran variedad y abundante oferta de alimentos y platos, lo que favorece las posibilidades de elección. Actualmente el consumo de alimentos es inferior al aconsejado para frutas, verduras, hortalizas, cereales integrales, pescados, huevos y lácteos, y supera lo aconsejado para carnes. Madrid es una de las comunidades autónomas con menor consumo y gasto per cápita en alimentación: se consumen menos alimentos, en general, y menos azúcares y grasas y aceites, en particular, respecto a la media nacional. La ingesta de proteínas y grasas es elevada, mientras que es insuficiente el aporte de hidratos de carbono complejos, fibra y diversos micronutrientes. El cambio en los hábitos alimentarios y el creciente sedentarismo favorece el incremento en el padecimiento de sobrepeso y obesidad, aunque el problema del exceso de peso es algo menor en Madrid respecto a otras comunidades, posiblemente por la menor ingesta energética. Conclusiones: la Comunidad de Madrid tiene una elevada disponibilidad de alimentos y una gran oferta gastronómica, lo que obliga a mejorar la educación y la formación del consumidor para que sus elecciones sean las más adecuadas para su salud y control de peso


Objectives: the nutrition and gastronomy are part of the strategies of maintenance and promotion of the health of the population. The aim of the present revision is to deep on the knowledge of the gastronomy and nutritional problems of the Community of Madrid. Methods: bibliographic search in relation to the subject. Results: the gastronomy of Madrid stands out for its great variety and abundant offer of food and dishes, which favors the possibilities of choice. The consumption of food is lower than that recommended for fruits, vegetables, whole grains, fish, eggs and dairy products and higher than recommended for meats. The Community of Madrid is one of those Autonomous Communities in Spain that consume and spent less per capita on food. Food consumption in general is lower than the national average, especially for sugars and fats and oils. There is a high intake of proteins and fats, an insufficient intake of complex carbohydrates and fiber, together with an inadequate intake of several micronutrients. The change in eating habits and the sedentary lifestyle favor the increase of the prevalence of overweight and obesity. Nevertheless, the problem of weight excess is somewhat lower in Madrid compared to other regions, perhaps because of its lower energy intake. Conclusions: the Community of Madrid is characterized by a high availability of food and a great gastronomic offer. This forces us to improve the nutritional education of the population, in order to facilitate the most appropriate selections for the improvement of health and weight control


Assuntos
Humanos , Animais , Bovinos , Preferências Alimentares , Estado Nutricional , Gorduras na Dieta/administração & dosagem , Consumo de Energia , Frutas , Nível de Saúde , Micronutrientes/administração & dosagem , Espanha/epidemiologia , Abastecimento de Alimentos , Laticínios , Açúcares da Dieta/administração & dosagem , Sobrepeso/epidemiologia , Verduras , Valor Nutritivo , Culinária , Ovos , Causas de Morte , Carne , Produtos Pesqueiros
7.
Nutr. hosp ; 36(extr.1): 115-120, jun. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-184958

RESUMO

Andalucía oriental se denomina Alta Andalucía por la elevada orografía de las cordilleras Béticas con las cumbres peninsulares más altas. Surge con la segmentación de España en provincias, e incluye Almería, Granada, Jaén y Málaga. Solo hay que detenerse en el fondo de nuestras ollas para encontrarnos el sincretismo de las tres grandes religiones monoteístas (árabe, judía y cristiana) que mezcló las fiestas de una con las comidas de otra y permitió la universalización de sus gastronomías; un sincretismo que ha llegado hasta hoy y hace difícil conocer el origen de una u otra receta. La cocina busca hoy la fusión entre el sabor y los ingredientes de la cocina tradicional con el saber y la técnica de la cocina moderna. La diversidad geográfica y climática de Andalucía oriental es proporcional a su despensa, y esta es la que surte su recetario. La población de Andalucía oriental se aparta del patrón mediterráneo y se acerca a la dieta global de los países desarrollados de Occidente. Esta tendencia a disminuir el consumo de alimentos propios de patrón mediterráneo parece mantenerse, aunque se observa una disminución en la caída de alguno de ellos. Además, el consumo elevado de grupos como el de carnes y derivados, bollería, dulces y azúcar tiende a moderarse. El patrón actual es compatible -como pone de manifiesto el estudio ANIBES- con unas ingestas elevadas de grasa saturada y total y de azúcares y una baja ingesta de fibra en un porcentaje importante de la población en España y, por tanto, en Andalucía


Eastern Andalusia, is also named Highland Andalusia, because the elevated orography of the Betics mountain range, with the highest Iberian Peninsula summits. This region arose with the division of the Spanish territory by provinces and currently includes Almeria, Granada, Jaen. You should only stop and look into the bottom of our cooking pots to find the syncretism of the three monotheistic religions, Christianity, Jewish and Muslin, which mixed parties of each one with meals of the others, thus allowing the globalization of their gastronomies that remained until nowadays and makes difficult to find the actual origin of a particular meal recipe. Modern cooking tries to find the fusion between tastes and ingredients of traditional cooking with current knowledge and technology. The geographic and climate diversities in Eastern Andalusia are proportional to its pantry, which in turn is the source of its meal recipes. The population of Eastern Andalusia is moving away of the Mediterranean pattern and getting closer to the developed Western countries diet. This trend to decrease the consumption of proprietary Mediterranean foods seems to be maintained in the last years although some of them start to recover. In addition, some food groups e.g. meat and meat derivatives, pastries and sweets, with actual elevated consumption, tend to be moderated. The current food pattern for the whole Spanish population, as well as for Eastern Andalusia, is compatible with high intakes of saturated fat, and total and free sugars, and low intakes of fiber in a high percentage of the Spanish population as reported by the ANIBES study


Assuntos
Humanos , Animais , Bovinos , Manipulação de Alimentos/métodos , Preferências Alimentares , Valor Nutritivo , Doces , Clima , Culinária/métodos , Características Culturais , Dieta Mediterrânea , Gorduras na Dieta/administração & dosagem , Fibras na Dieta , Açúcares da Dieta/administração & dosagem , Geografia , Produtos da Carne , Espanha
8.
Allergol. immunopatol ; 47(2): 133-140, mar.-abr. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-180801

RESUMO

Introduction: Cow's milk protein allergy (CMPA) is the most common food allergy in children worldwide. Some children have severe and persistent CMPA, with near-fatal reactions after exposure to trace amounts of cow's milk-proteins (CMP). Strict avoidance diet is difficult, negatively affects quality of life and represents a conservative approach. Therefore, different therapeutic strategies are necessary. Objective: We aimed to assess long-term efficacy and safety of oral immunotherapy (OIT) in children with severe and long-lasting IgE-mediated CMPA. Materials and methods: The authors present four case reports of patients with CMPA who underwent CMP-OIT, that have been under long-term follow-up up to nine years. We provide information about the clinical and laboratory evaluation. Skin prick tests (SPT), specific IgE and IgG4 were performed before, during, and after OIT. Immune profile after OIT was assessed by flow cytometry (lymphocyte subsets, regulatory T and B cells). Results: The success rate was 100%, and all patients currently have a free diet with minimal diary ingestion of 200mL CMP or equivalent. Specific IgE levels and SPT to CMP have progressively decreased, and specific IgG4 levels have increased. CD4+CD25+CD127/dim regulatory T cells were increased after OIT. Conclusions: OIT ensured a clinical tolerance state after up to nine years, confirmed by both clinical and immune profile, allowing a diet without restrictions, with high satisfaction from patients and caregivers. We emphasize that OIT should be performed only by allergy experts in the hospital setting, and that only motivated families should be enrolled, since it is essential to ensure CMP daily intake at home


No disponible


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Bovinos , Alérgenos/uso terapêutico , Dessensibilização Imunológica/métodos , Hipersensibilidade a Leite/terapia , Linfócitos T Reguladores/imunologia , Administração Oral , Alérgenos/imunologia , Seguimentos , Imunoglobulina E/metabolismo , Hipersensibilidade a Leite/imunologia , Tolerância Imunológica
9.
Allergol. immunopatol ; 46(6): 517-532, nov.-dic. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-177890

RESUMO

Background: The present study explores the professional opinion of a wide range of experts from the Iberian Peninsula (Spain and Portugal) and their degree of consensus about CMPA's prevention, diagnosis, treatment and progression. Material and methodsA 57-item survey divided in four blocks: Prevention (14 items), Diagnosis (10 items), Treatment (19 items) and Progression (14 items) was completed by 160 panellists, experts in CPMA management (116 Spain, 44 Portugal). Each one answered the questionnaire, formulated in Portuguese and Spanish, by individually accessing an online platform in two consecutive rounds. Five possible answers were possible: "completely agree", "agree", "neither agree nor disagree", "disagree" and "completely disagree". A modified Delphi method was used. Results: Consensus (more than 66% agree) was reached in 39 items (68.4%) and Discrepancy (less than 50% agree) in nine items (15.7%). Block separated analysis offers valuable differences regarding consensus. The Prevention block only reached 50%; the Diagnosis block 90%; the Treatment block 73.68%, showing a high degree of agreement on dietary treatment (15/16 items), and discrepancy or less agreement on immunotherapy treatments. The Progression block reached 71.4% consensus with discrepancy with regard to the time to perform oral food challenge and negatives prognosis consequences of accidental milk ingestion. Conclusions: This study displays the current opinions of a wide group of experts on CMPA from the Iberian Peninsula and evidence discussion lines in CMPA management. The questions on which there were situations of discrepancy, provide us with very useful information for promoting new, rigorous research enabling us to draw conclusions on these controversial aspects


No disponible


Assuntos
Humanos , Animais , Bovinos , Alérgenos/uso terapêutico , Anafilaxia/terapia , Dessensibilização Imunológica/métodos , Hipersensibilidade a Leite/terapia , Proteínas do Leite/uso terapêutico , Alérgenos/imunologia , Anafilaxia/diagnóstico , Anafilaxia/imunologia , Dietoterapia , Prova Pericial , Fórmulas Infantis , Hipersensibilidade a Leite/diagnóstico , Hipersensibilidade a Leite/imunologia , Proteínas do Leite/imunologia , Inquéritos e Questionários
10.
Allergol. immunopatol ; 46(6): 539-545, nov.-dic. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-177892

RESUMO

Background: Both breastfeeding and the moment at which introduction to solid food occurs have been associated with food allergy. Objective: To evaluate whether prolonged breastfeeding and the delayed introduction of whole cow's milk into an infant's diet are factors that can be associated with egg sensitization. Methods: This was a hospital-based case-control study, matched by age and sex: each study group comprised 97 atopic children. Additionally, logistic regression was used to identify the factors associated with egg protein sensitization. Results: The most common type of allergic disease among both groups was allergic rhinitis. After adjusting for possible confounding variables, a delayed introduction to whole cow's milk decreased the odds of egg protein sensitization; OR = 0.16 (95% CI: 0.07-0.36, p < 0.0001). Notably, breastfeeding during the first six months of life, regardless of whether it was the only milk an infant drank, increased the risk for sensitization to chicken eggs; OR = 5.54 (95% CI: 2.41-12.7, p < 0.0001). Conclusion: Prolonged breastfeeding, regardless of whether it was the only milk an infant drank, greatly increased the risk of egg sensitization. Interestingly, a delayed introduction to whole cow's milk was associated with a reduced possibility of becoming sensitized to eggs. Further studies are required to elucidate these findings


No disponible


Assuntos
Humanos , Animais , Feminino , Lactente , Pré-Escolar , Bovinos , Aleitamento Materno/estatística & dados numéricos , Estudos de Casos e Controles , Dietoterapia/estatística & dados numéricos , Hipersensibilidade a Ovo/epidemiologia , Rinite Alérgica/epidemiologia , Hipersensibilidade a Ovo/imunologia , Proteínas do Leite/imunologia , Rinite Alérgica/imunologia , Risco
11.
Allergol. immunopatol ; 46(3): 241-246, mayo-jun. 2018. graf, tab
Artigo em Inglês | IBECS | ID: ibc-172943

RESUMO

Background: The food atopy patch (APT) test has been used in previous studies to help the diagnosis of non-IgE mediated food allergies (FA). The aim of this study was to evaluate the efficacy of different cow's milk APT preparations to predict oral tolerance in children with previous non-IgE-mediated cow's milk allergy (CMA) diagnosis. Methods: Thirty-two patients non-IgE-mediated CMA diagnosed by oral food challenge (OFC) were enrolled to perform APT with three different cow's milk preparations (fresh, 2% in saline solution, 2% in petrolatum) and comparing with a new OFC after at least three months of diet exclusion. Results: Only six (18.7%) subjects presented positive OFC to cow's milk. No differences in gender, onset symptoms age, OFC age, Z-score, and exclusion period were found between positive and negative OFC patients. Preparations using fresh milk and powdered milk in petrolatum presented sensitivity equal to zero and specificity 92.3% and 96.1%. The preparation using powdered milk in saline solution showed sensitivity and specificity of 33.3% and 96.1%. Two patients presented typical IgE symptoms after OFC. Conclusion: Cow's milk APT presented a low efficacy to predict tolerance in patients with previous non-IgE-mediated CMA and should not be used in clinical routine. The presence of typical IgE reactions after OFC hallmark the necessity of previous IgE-mediated investigation for this patient group (AU)


No disponible


Assuntos
Humanos , Animais , Masculino , Feminino , Lactente , Gatos , Hipersensibilidade a Leite/diagnóstico , Testes do Emplastro/métodos , Hipersensibilidade Imediata/diagnóstico , Alérgenos/administração & dosagem , Alérgenos/imunologia , Bovinos , Tolerância Imunológica/imunologia , Proteínas do Leite/administração & dosagem , Proteínas do Leite/imunologia , Sensibilidade e Especificidade
14.
J. physiol. biochem ; 73(2): 207-214, mayo 2017. graf
Artigo em Inglês | IBECS | ID: ibc-168477

RESUMO

Vasoconstriction within the renal medulla contributes to the development of hypertension. This study investigated the role of reactive oxygen species (ROS) in regulating renal medullary and cortical blood perfusion (MBP and CBP respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar rats. CBP and MBP were measured using a laser-Doppler flow meter before and after intra-renal infusion of tempol, the superoxide dismutase (SOD) mimetic or tempol plus catalase, the hydrogen peroxide-degrading enzyme. Tempol infusion significantly elevated blood perfusion within the renal medulla (MBP) in both SHRSP (by 43 ± 7%, P < 0.001) and Wistar rats (by 17 ± 2%, P < 0.05) but the magnitude of the increase was significantly greater in the SHRSP (P < 0.01). When the enzyme catalase and tempol were co-infused, MBP was again significantly increased in SHRSP (by 57 ± 6%, P < 0.001) and Wistar rats (by 33 ± 6%, P < 0.001), with a significantly greater increase in perfusion being induced in the SHRSP relative to the Wistar rats (P < 0.01). Notably, this increase was significantly greater than in those animals infused with tempol alone (P < 0.01). These results suggest that ROS plays a proportionally greater role in reducing renal vascular compliance, particularly within the renal medulla, in normotensive and hypertensive animals, with effects being greater in the hypertensive animals. This supports the hypothesis that SHRSP renal vasculature might be subjected to elevated level of oxidative stress relative to normotensive animals (AU)


No disponible


Assuntos
Animais , Masculino , Bovinos , Anti-Hipertensivos/uso terapêutico , Antioxidantes/uso terapêutico , Catalase/uso terapêutico , Hipertensão/tratamento farmacológico , Rim , Circulação Renal , Óxidos N-Cíclicos/uso terapêutico , Medula Renal , Hipodermóclise , Estresse Oxidativo , Resistência Vascular , Acidente Vascular Cerebral , Terapia Combinada/efeitos adversos , Marcadores de Spin , Espécies Reativas de Oxigênio/metabolismo , Ratos Endogâmicos SHR , Ratos Wistar
16.
Rev. lab. clín ; 8(1): 3-7, ene.-mar. 2015. ilus
Artigo em Espanhol | IBECS | ID: ibc-135468

RESUMO

El cáncer escamoso de cabeza y cuello se caracteriza por su tendencia a la invasión local y a distancia, además de una alta predisposición a la aparición de segundas neoplasias. El proceso de invasión y metástasis es complejo y tiene múltiples etapas. Las metaloproteinasas de matriz 2 y 9, se sobreexpresan en el cáncer escamoso de cabeza y cuello donde actúan degradando la membrana extracelular favoreciendo así la invasión tumoral y la metástasis. El bacilo de Calmette-Guérin (BCG) ha sido usado como inmunomodulador en el tratamiento de algunos tipos de cáncer con buenos resultados. El propósito de este estudio es determinar el efecto de la activación inmune mediada por el BCG sobre la migración e invasión usando un modelo in vitro 3 D de cultivos de células tumorales de faringe cocultivadas con células mononucleares de sangre periférica en contacto o no con el BCG. Para determinar la expresión de las metaloproteinasas y p53 se realizó Western blot y para la migración e invasión, kits comerciales. Los resultados muestran disminución en la expresión de metaloproteinasas, p53 y en la migración en el grupo BCG (AU)


Head and neck squamous cell carcinoma is characterized by local invasion and a propensity for dissemination to cervical lymph nodes and recurrence. Cancer cell invasion and metastasis represent complex, multistep process. The remodelling of ECM by MMPs is one of the most crucial steps for cancer progression. MMP-2 and MMP-9, are over expressed in head and neck squamous cell carcinoma where they act to degrade the basement membrane thus promoting tumor invasion and metastasis. Bacillus Calmette-Guérin (BCG) has been used as an immunomodulator in treating some cancers with good results. The purpose of this study is to determine the effect of BCG immune activation in migration and metastasis using in vitro 3 D cultures pharyngeal tumor cells were co-cultured with previously isolated peripheral blood mononuclear cells, in experimental groups or cultured alone. MMPs and p53 was determinate by Western blot and the invasion-migration using commercial assays. Our results showed decreasing expression of MMPs, p53 and significantly reduced migration in BGC group (AU)


Assuntos
Humanos , Bovinos , Animais , Imunoterapia/instrumentação , Imunoterapia/enfermagem , Vacina BCG/administração & dosagem , Vacina BCG , Neoplasias de Cabeça e Pescoço/induzido quimicamente , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Neoplasias da Bexiga Urinária/diagnóstico , Neoplasias Faríngeas/metabolismo , Imunoterapia/métodos , Imunoterapia , Vacina BCG/farmacologia , Vacina BCG/uso terapêutico , Neoplasias de Cabeça e Pescoço/cirurgia , Neoplasias de Cabeça e Pescoço/terapia , Neoplasias da Bexiga Urinária/complicações , Neoplasias Faríngeas/prevenção & controle , Espanha/etnologia
17.
Eur. j. anat ; 19(1): 27-35, ene. 2015. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-133887

RESUMO

This study considers the distribution of various endocrine cells in islets of Langerhans in the pancreas of several species of domestic animal, including the dromedary camel (Camelus dromedarius) using immunohistochemistry, and relates our observations with reference to the well-documented general histology of the mammalian pancreas. The pancreatic islets were observed as compact areas of pale cells surrounded by darker presumably exocrine tissue. The most distinct delineation of the islets from the surrounding acini was in the horse and the least was in cattle. Insulin-immunoreactive cells (β-cells) were most abundant followed by glucagon- (α-), somatostatin- (∆-), and pancreatic polypeptide-immunoreactive (F- or PP-) cells in decreasing order, in all species except cattle where PP-cells were second to β-cells in their distribution. The most prominent special pattern was observed in the distribution of α- and β- cells in the pancreatic islet of the horse where α-cells were located in the center of the islet surrounded by β-cells. In the camel, β-cells were distributed throughout the islet in the center and the periphery. Alpha cells were mostly observed as clumps in the periphery area. Clumps of small number of ∆-cells and a few PP cells were found throughout the islet. In cattle, β-cells were distributed throughout the islets. Other cells occupied a more peripheral location. The physical differences in distribution of endocrine cells might result in differences in the need and interaction of hormones to each other in different species


No disponible


Assuntos
Animais , Ilhotas Pancreáticas/ultraestrutura , Células Endócrinas/ultraestrutura , Imuno-Histoquímica/métodos , Camelus , Cavalos , Bovinos , Hormônios , Pâncreas/fisiologia
18.
Nutr. hosp ; 31(1): 92-101, ene. 2015. tab
Artigo em Espanhol | IBECS | ID: ibc-132586

RESUMO

La leche de vaca es un alimento básico en la alimentación humana en todas las etapas de la vida. Su procesamiento industrial ha permitido el acceso generalizado a su consumo por parte de la población, lo que ha contribuido a mejorar notablemente su nivel de salud. Desde el punto de vista de su composición, la leche es un alimento completo y equilibrado, que proporciona un elevado contenido de nutrientes en relación con su contenido calórico, por lo que su consumo debe considerarse necesario desde la infancia a la tercera edad. Los beneficios de la leche de vaca no se limitan exclusivamente a su valor nutricional, sino que se extienden más allá y constituyen un factor de prevención en determinadas patologías afluentes como son la enfermedad cardiovascular, algunos tipos de cáncer, la hipertensión arterial o en patología ósea o dental. Puede contribuir también en la lucha frente al sobrepeso y la obesidad infantil. En los últimos años hemos asistido a un descenso preocupante en el consumo de leche entre la población española, condicionado al menos en parte por ideas equivocadas sobre su consumo y el de otros derivados lácteos. Este documento de consenso pretende revisar el estado actual de la cuestión en relación con los efectos del consumo de leche sobre la salud, al tiempo que hace una llamada a las instituciones y a las sociedades científicas para elaborar programas y campañas divulgativas sobre los beneficios del consumo de leche y derivados lácteos (AU)


Cow’s milk is a staple food for human consumption at all stages of life. Industrial processing has allowed widespread access to its consumption by the population, which has helped to significantly improve their health. From its composition point of view, milk is a complete and balanced food that provides high nutrient content in relation to its calorie content, so its consumption should be considered necessary from childhood to elderly. The benefits of cow’s milk are not limited to its nutritional value, but extend beyond and are a factor of prevention in certain non communicable pathologies as cardiovascular disease, some cancers, high blood pressure or bone or dental pathology. It can also help in the fight against childhood overweight and obesity. In recent years we have seen a worrying decline in milk consumption among the Spanish population, at least in part influenced by misconceptions about its consumption and of other dairy products. This consensus document aims to review the current state of the topic regarding the effects of milk consumption on health, while making a call to the institutions and scientific societies to develop programs and information campaigns about the benefits of milk and dairy products consumption (AU)


Assuntos
Humanos , Lactente , Recém-Nascido , Animais , Bovinos , Leite/metabolismo , Valor Nutritivo , Consenso , Laticínios , Fenômenos Fisiológicos da Nutrição do Lactente , Prevenção Primária , Espanha
19.
Rev. toxicol ; 32(2): 127-130, 2015. tab, ilus, mapas
Artigo em Espanhol | IBECS | ID: ibc-146474

RESUMO

La región del Magdalena medio es una zona de actividad industrial-minera con exploraciones y refinación de hidrocarburos. Por ello los animales que viven en esta área geográfica son afectados por la presencia de contaminantes, especialmente metales pesados. En este trabajo se estudiaron 40 animales adultos, sacrificados en el matadero de Barrancabermeja, procedentes de explotaciones bovinas cercanas a industrias con actividad petrolífera. Se determinó la presencia de plomo, cadmio, molibdeno y zinc en hígado, riñón, músculo y piel mediante espectrofotometría de absorción atómica y se compararon los resultados obtenidos con los límites máximos permisibles establecidos por la Unión Europea y el Codex Alimentarius [1,2]. Se encontró mayor concentración de todos los metales en Barrancabermeja excepto el Zn que presentó mayores niveles en Yondó. Un número importante de muestras hepáticas (90 y 50%), renales (75 y 15%) y musculares (85 y 90%) de ambas localizaciones superaron los valores permisibles de Pb tanto del Codex Alimentarius, como de la Unión Europea. Situación similar sucede con el Cd en Barrancabermeja, superando en el 85%, el 10% y la totalidad (100%) los valores permitidos por la Unión Europea en hígado, riñón y músculo respectivamente, mientras que en Yondó, 65% de las muestras hepáticas y todas las muestras musculares superan esos mismos límites. Por ello podemos concluir que el consumo de carne y vísceras de bovinos que pastorean en el Magdalena Medio Colombiano, representa un grave riesgo para la salud humana como consecuencia de su alto grado de contaminación con metales pesados (AU)


Middle Magdalena region is an area with an industrial-mining with exploration and refining of oil. Therefore the animals that live in this geographical area are affected by the presence of pollutants, especially heavy metals. In this study 40 adult animals slaughtered in the abattoir in Barrancabermeja, from bovine holdings nearby industries with petroleum extraction activities were studied. The presence of lead, cadmium, molybdenum and zinc in liver, kidney, muscle and skin was determined by atomic absorption spectrophotometry and the results obtained with the limits set by the European Union and the Codex Alimentarius were compared [1,2]. Higher concentration of all metals was found in Barrancabermejaexcept Zn presented higher levels in Yondó. A significant number of liver samples (90 and 50%), kidney (75 and 15%) and muscle (85 and 90%) of both locations exceeded the permissible values of Pb both the Codex Alimentarius and the European Union. A similar situation occurs with cd in Barrancabermeja, exceeding 85%, 10%and all (100%) values allowed by the European Union in liver, kidney and muscle respectively, while in Yondó, 65% of samples liver and muscle samples exceed all those same limits. Therefore we can conclude that the consumption of meat and offal from cattlegrazing in the Middle Magdalena Colombian, represents a seriousrisk to human health as a result of its high degree of contamination with heavy metals (AU)


Assuntos
Animais , Erosão Antrópica , Metais Pesados/efeitos adversos , Metais Pesados/toxicidade , Petróleo/toxicidade , Poluição por Petróleo/efeitos adversos , Poluição por Petróleo/análise , Poluição por Petróleo/prevenção & controle , Indústria de Petróleo e Gás/análise , Indústria de Petróleo e Gás/legislação & jurisprudência , Indústria de Petróleo e Gás/prevenção & controle , Doenças dos Bovinos/induzido quimicamente , Bovinos
20.
Rev. esp. patol ; 47(4): 235-241, oct.-dic. 2014. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-128037

RESUMO

En los últimos años en nuestro país se ha incrementado el consumo de carne picada, como reflejo de la actual crisis económica. Con el objeto de conocer la composición tisular y microbiológica de estos preparados cárnicos, se diseñó un estudio en el que se adquirieron siete envases de carne picada de vacuno en grandes superficies elegidas al azar, en el territorio de la comunidad de Madrid. Estos casos fueron procesados de forma convencional (fijación en formol e inclusión en parafina) para realizar un examen de su composición tisular y evaluar su estado de preservación con métodos convencionales de microscopía óptica. Se procedió a realizar antes de la fijación tisular, un cultivo microbiológico adicional. Los datos obtenidos reflejan en general la existencia de productos alimentarios de baja calidad y mal preservados, contaminados frecuentemente con flora bacteriana de tipo fecal (AU)


During recent years, probably due to the economic crisis, there has been an increase in the consumption of minced beef in Spain. A study was carried out to determine the tissue and microbiological composition of the minced beef on sale. Seven packets were bought randomly from shops throughout the region of Madrid and their contents processed with formalin fixation and paraffin embedding and examined by optical microscopy to examine tissue composition and the state of preservation. A microbiological study was also carried out. We found that these meat products were of poor quality, badly preserved and frequently contaminated with faecal bacteria (AU)


Assuntos
Animais , Masculino , Feminino , Bovinos , Carne/análise , Carne , Produtos da Carne/análise , 24966/análise , 24966/métodos , Carne/microbiologia , 24966/classificação , Meios de Cultura/normas , Bactérias/citologia , Bactérias/patogenicidade
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