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J. physiol. biochem ; 64(3): 231-240, jul.-sept. 2008. graf, tab
Artigo em Inglês | IBECS | ID: ibc-61828


The aim of the current study is to investigate the therapeutic and preventive effectsof 1á, 25dihydroxyvitaminD3 (1,25 (OH)2 D3) and Ajuga iva (AI) extract on diabetestoxicity in rats testes. Thus diabetic rats were treated with 1á, 25dihydroxyvitaminD3or Ajuga iva extract as both therapeutic and preventive treatments on diabetestoxicity in rats testes. Our results showed that diabetes induced a decrease intestosterone and 17â-estradiol levels in testes and plasma. Besides, a fall in testicularantioxidant capacity appeared by a decrease in both antioxidant (superoxide dismutase(SOD), catalase (CAT) and glutathione peroxidase (GPx) activities) and nonenzymaticantioxidant (copper (Cu), magnesium (Mg) and iron (Fe) levels). All theseschanges enhanced testicular toxicity (increase in testicular aspartate aminotransaminase (AST), alanine amino transaminase (ALT), lactate dehydrogenase(LDH) activities and the lipid peroxidation and triglyceride (TG) levels). In addition,a decrease in testicular total cholesterol (TCh) level was observed in diabetic ratstestes. All the changes lead to a decrease in the total number and mobility of epididymalspermatozoa. The administration of 1á,25dihydroxyvitaminD3 and Ajugaiva extract three weeks before and after diabetes induction interfered and preventeddiabetes toxicity in the reproductive system. 1,25 (OH)2 D3 and Ajuga iva extractblunted all changes observed in diabetic rats. To sum up, the data suggested that 1,25(OH)2 D3 and Ajuga iva extract have a protective effect on alloxan-induced damagein reproductive system by enhancing the testosterone and 17â-estradiol levels, consequentlyprotecting from oxidative stress, cellular toxicity and maintaining the numberand motility of spermatozoids (AU)

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Animais , Masculino , Ratos , Ajuga , Calcitriol/uso terapêutico , Vitaminas/uso terapêutico , Extratos Vegetais/metabolismo , Testosterona/análise , Antioxidantes/análise , Diabetes Mellitus Experimental/tratamento farmacológico , Fertilidade , Estresse Oxidativo , Triglicerídeos/análise , Diabetes Mellitus Experimental/fisiopatologia , Estradiol/fisiologia , Extratos Vegetais/uso terapêutico , Testículo/fisiopatologia , Colesterol/análise , Estradiol/análise , Peroxidação de Lipídeos , Estresse Oxidativo/fisiologia , Substâncias Protetoras , Ratos Wistar