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2.
J. investig. allergol. clin. immunol ; 29(5): 371-377, 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-188773

RESUMO

OBJECTIVE: The aim of this study was to assess the relationship between meteorological and pollution-related variables and the symptoms of patients with seasonal allergic rhinitis due to sensitization to grass pollen during 2 different time periods in Madrid, Spain. METHODS: Between March 23 and December 31 in 1996 and 2009, we carried out a daily count of grass pollen grains (Burkard spore trap) and recorded the rhinitis symptom scores in 2 groups of patients with a history of seasonal allergic rhinitis (n=25 in 1996 and n=23 in 2009). Descriptive statistics of the same variables during the study periods were recorded. Associations between variables were assessed using the paired-samples Wilcoxon test and categorical principal component analysis (CatPCA, SPSS24 package). RESULTS: The mean symptom score was low in 1996 and moderate in 2009. The 1996 and 2009 CatPCA analysis explained around 66.4% and 70.5% of the variance, respectively. The strongest relationships in 1996 were between symptoms and grass pollen counts (R=0.55) and between temperature and ozone (R=0.63). In 2009, the association between temperature and pollution-related variables was even stronger than in 1996 (ozone [R=0.53] and PM10 [R=0.34], with a positive sign in both cases). CONCLUSIONS: The effect of temperature and pollution (mainly ozone, even at lower atmospheric concentrations than in established guidelines for effects on health) may have contributed to the higher seasonal allergic rhinitis symptom score recorded in 2009


INTRODUCCIÓN: El objetivo de este estudio fue evaluar las relaciones de las variables meteorológicas y contaminantes en los síntomas de los pacientes con rinitis alérgica estacional con sensibilización al polen de gramíneas durante dos períodos diferentes en Madrid. MÉTODOS: Durante el período del 23 de marzo al 31 de diciembre de 1996 y 2009, se realizó un recuento diario de granos de polen de gramíneas (Burkard spore trap) y puntuación de síntomas de rinitis en dos grupos de pacientes (n = 25 en 1996 y n = 23 en 2009) con historia de rinitis alérgica estacional. Para describir cómo se relacionan las variables, se realizaron estadísticas descriptivas de las mismas variables en los períodos de estudio de 1996 y 2009, contraste no paramétrico pareado de Wilcoxon y un análisis de componentes principales (CatPCA, SPSS24). RESULTADOS: El valor medio de la puntuación de síntomas en 1996 fue bajo y en 2009 moderado. El análisis CatPCA de 1996 y 2009 explica aproximadamente el 66,4% y el 70,5% de la varianza, respectivamente. La relación más fuerte en 1996 fue entre los síntomas y los recuentos de polen de gramíneas (R = 0,55), la temperatura y el O3 (R = 0,63). En 2009, la relación entre la temperatura y las variables de contaminación fue incluso mayor que en el período de 1996: O3 (R = 0,53) y con PM10 (R = 0,34), en ambos casos con un signo positivo. CONCLUSIONES: El efecto de la temperatura y la contaminación (principalmente O3, incluso a concentraciones atmosféricas más bajas que las pautas establecidas sobre sus efectos en la salud), podría contribuir a la mayor puntuación de síntomas de rinitis alérgica estacional observada en 2009


Assuntos
Humanos , Masculino , Feminino , Poluição do Ar/efeitos adversos , Alérgenos/imunologia , Poaceae/efeitos adversos , Pólen/imunologia , Rinite Alérgica Sazonal/epidemiologia , Rinite Alérgica Sazonal/etiologia , Conceitos Meteorológicos , Vigilância em Saúde Pública , Rinite Alérgica Sazonal/diagnóstico , Rinite Alérgica Sazonal/história , Estações do Ano , Índice de Gravidade de Doença , Espanha/epidemiologia , Avaliação de Sintomas
3.
Allergol. immunopatol ; 46(6): 599-606, nov.-dic. 2018. tab, graf, ilus
Artigo em Inglês | IBECS | ID: ibc-177901

RESUMO

Introduction and Objectives: Aeroallergens are airborne organic substances which are responsible for allergenic diseases in hypersensitive individuals. People are exposed to their allergens either directly or after their entrance into the interiors. The spatio-temporal pattern of aeroallergens and their relationship with weather variability in Abuja and Nassarawa, North-Central Nigeria was studied. Materials and Methods: Aerosamples were trapped with modified Tauber-like pollen traps. Samples were collected monthly and centrifuged at 2500 rpm for 5 min and subjected to acetolysis. Meteorological data were collected from the Nigerian Meteorological Agency. Results and Conclusion: Aeroallergens concentration were unequivocally regulated by weather variables in both locations, indicating the possible use of aeroallergens especially pollen and spores as bio-indicators of weather variations and change. Aeroallergens encountered were fungal spores, pollen, diatom frustules, fern spores, algal cyst/cells in decreasing order of dominance. Among pollen group, Poaceae, Amarathaceae/Chenopodiaceae and Hymenocardia acida dominated. Spores of Smut species, Puccinia, Curvularia and Nigrospora were major contributors among aeromycoflora. Fungal spores morphotype dominated during the rainier months and were major contributors of the aeroallergen spectrum with those belonging to Deuteromycete preponderant. Aeroallergens which were previously identified as triggers of conjunctivitis, asthma, allergic sinusitis and bronchopulmonary allergic diseases were frequently present in both locations. Pollen prevailed more during the harmattan, influenced by northeast trade wind. Pollen component differed and was based on autochthonous source plants, indicating difference in sub-vegetational types


No disponible


Assuntos
Humanos , Animais , Ar/análise , Asma/epidemiologia , Alérgenos/imunologia , Asma/imunologia , Material Particulado/imunologia , Pólen/imunologia , Esporos Fúngicos/imunologia , Alérgenos/química , Diatomáceas/imunologia , Hipersensibilidade/epidemiologia , Nigéria/epidemiologia , Material Particulado/química , Poaceae/imunologia , Pólen/química , Estações do Ano , Esporos Fúngicos/química , Ustilago/imunologia
5.
Allergol. immunopatol ; 44(3): 232-240, mayo-jun. 2016. graf
Artigo em Inglês | IBECS | ID: ibc-152079

RESUMO

Background: Gramineae bee-collected pollen is identified as being at the origin of allergic accidents but the biological potency of Gramineae bee-collected pollen is not well known. Cereal grasses (e.g., Zea) and European wild forage grasses (FG) are contained in bee-collected pollen. Method: In this experiment, Zea-mass and FG-mass were identified in bee pollen mass and the proportion of Zea and of FG was calculated using the bee pollen melissopalynology spectrum. Skin reactivity to Zea and to FG were assessed by measuring wheal diameters (W) from skin prick tests using three serial dilutions of bee-collected pollen on 10 allergic patients to Gramineae, in order to calculate the relationship between Zea mass (Masszea) or FG mass (MassFG) in bee pollen and skin reactivity. Results: The linear function Log10(WFG) = 0.24(Log10(MassFG)) + 0.33 (R = 0.99) was established using a bee pollen sample with 0.168 mg of FG pollen per mg. The linear function Log10(Wzea) = 0.23(Log10(Masszea)) + 0.14 (R = 0.99) was established using a bee pollen sample with 0.983 mg of Zea pollen per mg. Gramineae allergens seem to be little altered by bee secretions. Gramineae bee pollen retains its allergenic capacity but it depends on the members of the Gramineae family. Conclusions: To our knowledge this is the first time it has been shown that skin reactivity to Gramineae is proportional to the absolute Gramineae mass contained in the bee-collected pollen and that it depends on the members of the Gramineae family (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Pólen/efeitos adversos , Pólen/imunologia , Pólen/fisiologia , Rinite Alérgica Sazonal/diagnóstico , Rinite Alérgica Sazonal/imunologia , Rinite Alérgica Sazonal/patologia , Zea mays/efeitos adversos , Zea mays/imunologia , Zea mays/envenenamento , Poaceae/imunologia , Poaceae/envenenamento , Poaceae/toxicidade , Venenos de Abelha/efeitos adversos , Venenos de Abelha/envenenamento , Abelhas/imunologia , Abelhas/fisiologia , Abelhas/patogenicidade , Alérgenos/efeitos adversos , Alérgenos/análise , Alérgenos/imunologia
6.
J. investig. allergol. clin. immunol ; 26(6): 362-365, 2016. tab
Artigo em Inglês | IBECS | ID: ibc-159023

RESUMO

Background: Polcalcins are highly cross-reactive pollen panallergens. Less than 10% of allergic patients are sensitized to polcalcins. All pollen species are considered able to sensitize patients to this panallergen. Objective: We aimed to assess the presence of polcalcins in various pollen extracts used in allergen immunotherapy. Methods: ELISA inhibition experiments were performed with sera from patients sensitized to polcalcin and rPhl p 7 and rBet v 4. Recombinant polcalcin was used as the substrate and freshly prepared pollen extracts as inhibitors. Results: All pollen extracts induced significant inhibition of IgE reactivity to rBet v 4, whereas only grass pollen extract induced marked inhibition of IgE reactivity to rPhl p 7. Conclusion: Grass polcalcin probably contains more epitopes than polcalcins from other pollen sources. Grass pollen could be responsible for sensitization to polcalcins, and grass pollen immunotherapy is likely to be an option for polcalcin-hypersensitive patients (AU)


Antecedentes: Las polcalcinas son panalérgenos de alta reactividad cruzada en pólenes capaces de sensibilizar a un 10% de los pacientes alérgicos. Todas las especies de pólenes se consideran capaces de sensibilizar pacientes mediante este panalérgeno. Objetivo: El objetivo de este trabajo fue analizar la presencia de esta polcalcina en diferentes extractos de pólenes que se utilizan en inmunoterapia. Método: El suero de pacientes reactores a polcalcina, así como frente a rPhl p 7 y a rBet v 4 fue analizado mediante ensayo de ELISA inhibición, utilizando polcalcina recombinante como sustrato y extracto de pólenes como inhibidores. Resultados: En cuanto a los resultados obtenidos, todos los extractos de pólenes indujeron una inhibición significativa de la reactividad de la IgE frente a rBet v 4, mientras que solo el extracto de polen de gramíneas inducía una marcada inhibición de la reactividad de la IgE frente a rPhl p 7. Conclusión: La polcalcina de gramíneas probablemente contiene más epítopes que las polcalcinas de otras fuentes. El polen de gramíneas podría ser responsable de la sensibilización a la polcalcina y la inmunoterapia con polen de gramíneas es probablemente una opción para los pacientes hipersensibles a polcalcina (AU)


Assuntos
Humanos , Masculino , Feminino , Alérgenos/imunologia , Alérgenos/isolamento & purificação , Dessensibilização Imunológica/métodos , Imunoterapia/métodos , Pólen/imunologia , Hipersensibilidade Imediata/imunologia , Imunoglobulina E/análise , Imunoglobulina E/imunologia , Imunoglobulina E/isolamento & purificação , Ensaio de Imunoadsorção Enzimática/métodos , Ensaio de Imunoadsorção Enzimática/tendências , Poaceae/imunologia
7.
J. investig. allergol. clin. immunol ; 26(2): 83-91, 2016. tab, graf
Artigo em Inglês | IBECS | ID: ibc-152597

RESUMO

Background: Local allergic rhinitis (LAR) is a phenotype of allergic rhinitis characterized by the presence of a localized immune response in the nasal mucosa of patients with negative skin prick test (SPT) results and undetectable serum specific IgE (sIgE). It unknown whether LAR is limited to areas with low or moderate aeroallergen exposure. Objective: To explore the presence of LAR and the clinical and immunological characteristics of this entity in geographic areas with high grass pollen loads. Methods: A cross-sectional observational study was carried out in 2 hospitals in central Spain (Madrid and Ciudad Real). Sixty-one patients with seasonal rhinitis and negative SPT results and undetectable serum sIgE were evaluated using a clinical questionnaire, determination of serum total IgE, and a nasal allergen provocation test (NAPT) with Phleum species. The response to NAPT was monitored using assessment of nasal symptoms, acoustic rhinometry, and determination of sIgE, tryptase, and eosinophil cationic protein in the nasal cavity. Results: Seasonal LAR was detected in 37 patients (61%) using the techniques described above. Eleven percent of patients with LAR were adolescents or children, and 14% reported onset of rhinitis in childhood. Most patients reported persistent-moderate seasonal nasal symptoms, and 41% reported worsening of the disease during the last 2 years. Conjunctivitis was the most common comorbidity, affecting 95% of cases. Conclusions: LAR to grass pollen is relevant in patients with seasonal symptoms indicative of allergic rhinitis but with a negative skin test result who live in areas with high allergenic pollen loads. This entity should be included the differential diagnosis of rhinitis (AU)


Introducción: La rinitis alérgica local (RAL) es un fenotipo de rinitis alérgica (RA) caracterizado por la presencia de una respuesta inmunológica localizada en la mucosa nasal de pacientes con pruebas cutáneas (PC) negativas e IgE específica (sIgE) sérica no detectable. Se desconoce si la RAL es una entidad limitada a áreas con baja o moderada exposición a aeroalérgenos. Objetivos: Explorar la presencia y características clínico-inmunológicas de la RAL en áreas geográficas con alta concentración atmosférica de polen de gramíneas. Métodos: Estudio observacional-transversal realizado en dos hospitales de la zona centro de España (Madrid y Ciudad Real). Sesenta y un pacientes con rinitis estacional, PC negativas y sIgE sérica no detectable fueron evaluados mediante cuestionario clínico, IgE total sérica, y test de provocación nasal con Phleum (TPN-Phleum). La respuesta al TPN se monitorizó mediante síntomas, rinometría acústica, y determinación de sIgE, triptasa y proteína catiónica de eosinófilos en secreciones nasales. Resultados: Se detectó RAL estacional en 37 pacientes (61%) mediante TPN-Phleum. El 11% de los pacientes eran adolescentes o niños, y el 14% habían comenzado con los síntomas en la infancia. La mayoría presentaban rinitis estacional persistente-moderada, y el 41% refirió empeoramiento en los 2 últimos años. La conjuntivitis fue la enfermedad asociada más frecuente, afectando al 95% de los sujetos con RAL. Conclusiones: La RAL por polen de gramíneas es una enfermedad frecuente en pacientes con síntomas indicativos de RA estacional y PC negativas que viven en áreas con alta concentración atmosférica de pólenes, y debe ser incluida en el diagnostico diferencial de la rinitis (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Rinite Alérgica/complicações , Rinite Alérgica/diagnóstico , Rinite Alérgica/imunologia , Relação Dose-Resposta Imunológica , Hipersensibilidade Imediata/imunologia , Rinometria Acústica/métodos , Diagnóstico Diferencial , Poaceae/efeitos adversos , Imunidade nas Mucosas , Imunidade nas Mucosas/imunologia , Testes Cutâneos/métodos , Testes Cutâneos/tendências , Estudos Transversais/instrumentação , Estudos Transversais/métodos , Estudos Transversais , Inquéritos e Questionários
8.
J. investig. allergol. clin. immunol ; 26(5): 295-303, 2016. tab, graf
Artigo em Inglês | IBECS | ID: ibc-157354

RESUMO

Background and Objectives: The homologous group of sweet grasses belongs to the Pooideae subfamily, but grass pollen species from other subfamilies can also cause allergy, such as Cynodon dactylon (Chloridoideae) and Phragmites communi (Arundinoideae). C dactylon and P communis have not been included in the sweet grasses homologous group because of their low cross-reactivity with other grasses. The aims of this study were to investigate the profile of sensitization to C dactylon and P communis in patients sensitized to grasses and to analyze cross-reactivity between these 2 species and temperate grasses. Methods: Patients were skin prick tested with a grass mixture (GM). Specific IgE to GM, C dactylon, P communis, Cyn d 1, and Phl p 1 was measured by ImmunoCAP. A pool of sera was used for the immunoblot assays. Cross-reactivity was studied by ELISA and immunoblot inhibition. Results: Thirty patients had sIgE to GM. Twenty-four (80%) had positive results for C dactylon, 27 (90%) for P communis, 22 (73.3%) or nCyn d 1, and 92.9% for rPhl p 1. Bands were detected in the 3 extracts by immunoblot. Inhibition of GM was not observed with C dactylon or P communis by immunoblot or ELISA inhibition. When C dactylon or P communis were used in the solid phase, GM produced almost complete inhibition. Conclusions: Eighty percent of patients sensitized to grasses were also sensitized to C dactylon and 90% were sensitized to P communis. Sensitization to these species seems to be induced by allergens different to those in sweet grasses (AU)


Antecedentes y Objetivos: Desde un punto de vista taxonómico, el grupo homólogo de las gramíneas pertenece a la sub-familia Pooideae. Sin embargo, existen también otras especies de gramíneas alergénicas que pertenecen a sub-familias diferentes como son Cynodon dactylon (Chloridoideae) o Phragmites communis (Arundinoideae). C. dactylon y P. communis no están incluidas en este grupo homólogo debido a que la reactividad cruzada con otras gramíneas es limitada. Los objetivos del estudio fueron investigar el perfil de sensibilización a C. dactylon y P. communis en pacientes sensibilizados a gramíneas y analizar la reactividad cruzada entre estas dos especies y las gramíneas más comunes. Métodos: A los pacientes se les realizó una prueba cutánea con una mezcla de gramíneas (MG). Mediante ImmunoCAP se midió la IgE específica para MG, C. dactylon P. communis , Cyn d 1 y Phl p 1. Un pool de sueros se utilizó para ensayos de inmunoblot. La reactividad cruzada se estudió mediante ELISA e inmunoblot inhibición Resultados: Treinta pacientes tuvieron IgE específica para MG. Veinticuatro (80%) fueron positivos a C. dactylon, 27 (90%) a P. communis, 22 (73,3%) a nCyn d 1 y 92,9% fueron positivos a rPhl p 1. Se detectaron bandas en los tres extractos mediante inmunoblot. No se observó inhibición de MG con las otras dos especies mediante inmunoblot o ELISA inhibición. Cuando C. dactylon o P. communis se usaron en fase sólida, MG produjo una inhibición casi completa. Conclusiones: El 80% de los pacientes sensibilizados a gramíneas estaban también sensibilizados a C. dactylon y el 90% a P. communis. La sensibilización a estas especies parece estar inducida por diferentes alérgenos que en el caso de gramíneas (AU)


Assuntos
Humanos , Masculino , Feminino , Poaceae/efeitos adversos , Poaceae/imunologia , Pólen/efeitos adversos , Alérgenos/efeitos adversos , Alérgenos/imunologia , Cynodon/efeitos adversos , Cynodon/classificação , Testes Cutâneos/métodos , Testes Cutâneos , Poaceae/classificação , Hipersensibilidade Imediata/diagnóstico , Hipersensibilidade Imediata/imunologia , Imunoglobulina E/análise , Ensaio de Imunoadsorção Enzimática/métodos
10.
J. investig. allergol. clin. immunol ; 25(3): 190-195, 2015. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-136424

RESUMO

Antecedentes: El ImmunoCAP ISAC 112, es el único sistema comercial con determinación simultánea de múltiples alérgenos comercializado para el diagnóstico alergológico molecular. No existen estudios comparativos de este sistema con el ImmunoCAP para la determinación de IgE frente a un único alérgeno. Objetivos: Realizar un estudio comparativo para la determinación de IgE específica a alérgenos de polen de gramíneas en pacientes alemanes con alergia a estos pólenes, utilizando los sistemas ISAC IgE y el ImmunoCAP IgE. Métodos: Se estudiaron 101 sueros de adultos con alergia a pólenes de gramíneas, determinando la IgE específica a 8 alérgenos de hierba timotea mediante ImmunoCAP y a 112 alérgenos presentes en la plataforma ISAC. Posteriormente se realizó un análisis estadístico comparativo entre los resultados de ambos sistemas. Resultados: La comparación de los valores de IgE específica frente a los alérgenos de pólenes de gramíneas hallados en los sistemas ISAC e ImmunoCAP mostraron los siguientes coeficientes de correlación: 0.88 (rPhl p 1), 0.96 (rPhl p 2), 0.70 (nPhl p 4), 0.94 (rPhl p 5b), 0.92 (rPhl p 6), 0.85 (rPhl p 11) y 0.78 (rPhl p12). Conclusiones: El diagnóstico molecular con el Sistema ISAC guarda buena correlación con los resultados del ImmunoCAP para los alérgenos de hierba timotea presentes en ambas plataformas (AU)


Background: The ImmunoCAP ISAC 112 platform is the only commercially available molecular allergy IgE multiplex test. Data on the comparison of this rather novel test with the molecular singleplex ImmunoCAP IgE platform are lacking. Objective: To compare the multiplex ISAC 112 platform and the singleplex ImmunoCAP platform in regard to IgE to grass pollen allergens in untreated grass pollen–allergic patients in Germany. Methods: Serum samples from 101 adults with grass pollen allergy were analyzed for specific IgE (sIgE) to 8 allergenic molecules from timothy grass pollen and to the 112 allergenic molecules included in the ISAC panel. The results for the multiplex and singleplex tests were subsequently analyzed statistically. Results: Comparison of sIgE to grass pollen allergens detected by ISAC 112 and the singleplex ImmunoCAP assay revealed the following correlation coefficients: 0.88 (rPhl p 1), 0.96 (rPhl p 2), 0.70 (nPhl p 4), 0.94 (rPhl p 5b), 0.92 (rPhl p 6), 0.85 (rPhl p 11), and 0.78 (rPhl p12). Conclusion: Molecular testing with ISAC 112 correlates well with the ImmunoCAP platform for respective molecular timothy grass pollen allergens (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Reação em Cadeia da Polimerase Multiplex/tendências , Reação em Cadeia da Polimerase Multiplex , Hipersensibilidade Imediata/imunologia , Imunoglobulina E/imunologia , Pólen/efeitos adversos , Pólen/imunologia , Alérgenos/análise , Alérgenos , Alérgenos/imunologia , Dessensibilização Imunológica/métodos , Dessensibilização Imunológica , Poaceae/efeitos adversos , Rinite/complicações
12.
An. sist. sanit. Navar ; 34(1): 43-50, ene.-abr. 2011. tab
Artigo em Espanhol | IBECS | ID: ibc-97852

RESUMO

Introducción. La prevalencia de las enfermedades alérgicas ha aumentado últimamente, especialmente en países industrializados. Puesto que la alergia está influenciada por factores genéticos y ambientales, la población inmigrante constituye un buen modelo epidemiológico para valorar influencia del ambiente. Presentamos las características clínicas de alergia respiratoria en población inmigrante del centro de España. Métodos. Se recogieron datos prospectivamente de 62 pacientes inmigrantes y 33 españoles que acudieron en marzo de 2010 a 7 hospitales de Madrid, Cuenca y Ciudad Real, diagnosticados de alergia respiratoria mediante un estudio alergológico estándar. Resultados. El 63% eran mujeres, edad media 28,4 años. Sus países de origen se distribuyeron en 3 grupos (Norte de África, Latinoamérica, Europa del Este). El 96% presentaban rinitis, aunque sólo el 48% de españoles frente al 76,9% de hispanos sufrían rinitis persistente. La prevalencia de asma fue similar, aunque entre hispanos el porcentaje de asma controlada fue menor. El tiempo de evolución fue menor en pacientes inmigrantes. El polen de gramíneas resultó el alérgeno más relevante salvo en pacientes árabes. La incidencia de sensibilización a polcalcina fue muy baja. Por el contrario, el 44,1% de españoles presentaban sensibilización aprofilina, frente al 4,88 de hispanos, aunque no implicaba sintomatología al tomar vegetales en la mayoría de casos. Conclusiones. Este estudio multicéntrico muestra diferencias significativas en tiempo de evolución y perfiles de sensibilización entre pacientes españoles e inmigrantes con alergia respiratoria. Además, diferencias en la expresión clínica de la rinitis y peor control del asma, pueden condicionar peor evolución clínica en el colectivo inmigrante(AU)


Introduction. The prevalence of allergic diseases has increased worldwide in the last two decades, particularly in developed countries. Respiratory allergy is determined by genetic heredity, influenced by environmental factors. Migration is a good epidemiological model for assessing the influence of the environment. We present the clinical characteristics of respiratory allergy in immigrants in the central region of Spain. Methods. We prospectively collected data on all immigrants referred to the allergy units of 7 different hospitals in Madrid, Cuenca and Ciudad Real in March 2010. Respiratory Allergy was diagnosed using a standard study for allergic diseases. Results in immigrants were compared with data from a similar Spanish population. Results. Sixty-two immigrants and 32 Spanish patients were evaluated (63% female, mean age 28.4 years). Their countries of origin were uniformly distributed among 3 macro areas (North of Africa, Latin America, and Eastern Europe). More than 96% presented rhinitis, although persistent rhinitis was more prevalent amongst Latin Americans (76.9%) than in the Spanish population (48%). No differences were observed in asthma prevalence, although immigrants had higher rates of non-controlled and partially controlled asthma. The meantime of onset of symptoms after immigration was 43 months. Grass pollen was the most relevant allergen with the exception of Arab patients. Sensitization to polcalcin was rare. Otherwise, 44.1% of the Spanish population was sensitized to profilin (only 4.88% among immigrants) although this sensitization did not associate allergy to fruits or other vegetables. Conclusions. In summary, a multicentric study is presented where significant differences have been observed in the sensitization pattern and clinical evolution of respiratory allergy in immigrants and the Spanish population(AU)


Assuntos
Humanos , Hipersensibilidade Respiratória/epidemiologia , Migração Humana/tendências , Asma/epidemiologia , Rinite Alérgica Sazonal/epidemiologia , Rinite Alérgica Perene/epidemiologia , Estudos Prospectivos , Poaceae/efeitos adversos , Pólen/efeitos adversos
13.
Rev. iberoam. micol ; 23(3): 179-184, sept. 2006. tab
Artigo em Inglês | IBECS | ID: ibc-75386

RESUMO

The occurrence of fungi in the Mira salt marsh, Portugal was investigated for 12 months. Baits of Spartina maritima stems were exposed to permanent or temporary submersion at the upper and lower limits of the intertidal zone. The baits were observed for fruit bodies and spores directly and after incubation in moist chambers. Twenty six marine species were identified (17 Ascomycota, two Basidiomycota and seven mitosporic fungi). Twenty four are new records for Portugal. Nia globospora Barata and Basílio was published as a new species. Species were characterized with respect to frequency of occurrence, colonization capability and substrate succession. The diversity and similarity indexes of the fungi under different conditions were determined(AU)


Assuntos
Fungos/classificação , Fungos/isolamento & purificação , Fungos Mitospóricos/isolamento & purificação , Rios/microbiologia , Microbiologia da Água , Ascomicetos/isolamento & purificação , Basidiomycota/isolamento & purificação , Biodiversidade , Ecossistema , Poaceae/microbiologia , Portugal/epidemiologia , Especificidade da Espécie , Esporos Fúngicos
14.
Allergol. immunopatol ; 33(6): 296-302, nov. 2005. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-044231

RESUMO

Objective: To investigate the health and monetary consequences of treating allergy with specific immunotherapy (SIT) compared with symptomatic treatment/standard care among patients with grass pollen or mite allergy. Methods: We performed an economic analysis based on 253 grass- and/or mite allergic patients who started SIT from 1.1.1996 to 1.1.2002 at the Allergy Unit, Aarhus University Hospital and at a specialist practice in Aarhus. Relevant data were collected before, during and after SIT treatment from the national health service based on each patient's personal identification number and medical records and from a specifically designed questionnaire. A cost-benefit analysis including direct and indirect costs before, during and after SIT was performed. In addition direct costs were related to the clinical effect (improvement in well-being) in the form of a cost-effectiveness analysis. Results: The direct cost per patient/year before SIT (equivalent to standard care) was DKK 2,580. The investment in SIT was DKK 27,545 (in present values) per patient over a 4-year period. After SIT the cost was reduced to DKK 1,072 per patient/year. In the long term, prospective introduction of SIT incurred additional present-value direct costs of DKK 13,676 per patient treated and DKK 2,784 per patient/year of improved well-being. However, when indirect costs were included in the economic evaluation SIT was shown to be net beneficial. Conclusion: This study reveals that SIT is associated with initial resource investments and subsequent resource savings in the long term compared with standard care. When all consequences are measured in monetary terms, and assuming that sick days are associated with a loss of productivity, this analysis suggests that SIT increases societal welfare. This conclusion also holds if there is no loss of productivity


No disponible


Assuntos
Adulto , Adolescente , Pessoa de Meia-Idade , Humanos , Alérgenos/uso terapêutico , Dessensibilização Imunológica/economia , Pólen/efeitos adversos , Rinite Alérgica Perene/terapia , Ácaros/imunologia , Rinite Alérgica Sazonal/terapia , Alérgenos/efeitos adversos , Alérgenos/imunologia , Antígenos/efeitos adversos , Antígenos/imunologia , Dinamarca/epidemiologia , Hospitais Universitários , Poaceae , Pólen/imunologia , Rinite Alérgica Perene/epidemiologia , Rinite Alérgica Sazonal/epidemiologia
16.
Allergol. immunopatol ; 33(5): 264-269, sept. 2005. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-042136

RESUMO

Background: Treatment of allergic disease can be done by pharmacological intervention by allergen avoidance ­ in the following called standard care (SC), or by specific treatment with allergy vaccination; Specific Immunotherapy (SIT). The aim of this study were to evaluate the effects of subcutaneously administrated SIT compared to SC by objective (clinical/medical records) and subjective parameters (patient's opinion) in a before/after SIT study. Methods: The study included retrospectively all grass- and mite allergic 16-60 year old patients (N = 253) who had started SIT for grass pollen or mite allergy during the period 1.1.1996-1.1.2002 at The Allergy Unit, Aarhus University Hospital, or at a specialist practice in Aarhus. Relevant data were collected before/after treatment from medical records and from a specific designed questionnaire. The following indicators for effect were applied: Success of immunotherapy expressed as completion of up dosing phase, change in symptoms, a comparison of overall rhinoconjunctivitis symptoms, number of symptom free days per year, effect of pharmaceuticals, change in physical and psychological wellbeing and number of lost days from work/education and leisure activities. Results: Compliance for completed up dosing for SIT was 94 % (95 % CI 90-97). The questionnaire revealed that after SIT there were a significant reduction in degree of symptoms, 84 % (95 % CI 79-89) of the respondents achieved a reduction in over all rhinoconjunctivitis score, there were an increase in symptom free days per year, a decrease in days off/incapacity from work/education and leisure activities, an improved effect of the pharmaceuticals used for allergic symptoms and an improvement in physical and psychological wellbeing. The study also showed that SIT was more effective treating rhinoconjunctivitis symptoms than lung symptoms. Conclusion: The study revealed great advantages of SIT compared to SC and a high compliance for SIT during the up dosing period


No disponible


Assuntos
Adulto , Adolescente , Pessoa de Meia-Idade , Humanos , Alérgenos/uso terapêutico , Conjuntivite Alérgica/terapia , Dessensibilização Imunológica , Pólen/efeitos adversos , Hipersensibilidade Respiratória/terapia , Rinite Alérgica Perene/etiologia , Rinite Alérgica Perene/terapia , Ácaros/imunologia , Rinite Alérgica Sazonal/etiologia , Rinite Alérgica Sazonal/terapia , Alérgenos/efeitos adversos , Asma/etiologia , Asma/terapia , Conjuntivite Alérgica/etiologia , Poaceae , Pólen/imunologia , Inquéritos e Questionários
17.
Acta otorrinolaringol. esp ; 56(3): 112-115, mar. 2005. ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-038146

RESUMO

Introducción: La inmunoterapia es la administración de dosis crecientes del antígeno responsable del proceso alérgico para determinar una tolerancia inmunológica adecuada. Pacientes y Métodos: Se realiza un estudio descriptivo, transversal y retrospectivo en 30 pacientes diagnosticados de rinitis alérgica estacional, tratados con inmunoterapia sublingual. Se analizan una serie de variables (edad, género, síntomas, test cutáneo pre y posvacunación, tratamientos, evolución y efectos secundarios) con el programa estadístico SPS-S. Resultados: El 90% presentaba síntomas moderados y el 10% síntomas severos y asma. Los alérgenos más frecuentes fueron las gramíneas (33,3%). El 60% delos pacientes precisaba antihistamínicos y corticoides tópicos prevacunación. En el 80% no hubo efectos secundarios. La desensibilización completa ocurrió en el 53,3% de los pacientes y en el 73% hubo una mejoría clínica. El 54% de los casos no precisaba tratamiento posvacunación. Conclusiones: La inmunoterapia ha demostrado ser el único tratamiento curativo, siendo la vía sublingual una de las más aceptadas, ya que usa mayor dosis de alergeno, es bien tolerada, disminuye la sintomatología y la necesidad de tratamiento y los efectos secundarios son mínimos


Introduction: Specific immunotherapy consists in administering increasing doses of antigen, to which the patientis sensitive, to determine a protective immune response. Patients and Methods: A descriptive and retrospective review of 30 patients diagnosed of seasonal allergic rhinitis, all treated with specific immunotherapy. Data on age, gender, symptoms, prick test before and after the immunotherapy administration, drugs, efficacy and side effects, were recorded using the SPS-S statistical program. Results: 90%had moderated symptoms and 10% had severe symptoms and asthma. 33% were sensitized to grass pollen. 60% needed antihistamines and intranasal corticosteroids before the immunotherapy. In a lot of cases (80%) there were no side effects. The complete desensitization occurred in 53,3% and the reduction of symptoms in 73% of the cases. 54% of the patients didn’t need treatment after specific immunotherapy. Conclusions: The specific immunotherapy is the only curative therapy. Sublingual therapy is one of the most accepted because is well tolerated, it uses a higher allergen concentration, it reduces the symptoms and the needs of drugs and side effects are uncommon


Assuntos
Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Adolescente , Humanos , Dessensibilização Imunológica/métodos , Rinite Alérgica Sazonal/terapia , Alérgenos/administração & dosagem , Administração Sublingual , Poaceae/efeitos adversos , Dessensibilização Imunológica/efeitos adversos , Asma/etiologia , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Pólen
18.
Allergol. immunopatol ; 32(5): 271-277, sept. 2004.
Artigo em Inglês | IBECS | ID: ibc-35467

RESUMO

We performed a prospective, multicenter study to assess the tolerance and possible short-term effects of allergen vaccines administered according to a cluster schedule in the months immediately preceding the onset of the pollen season. The study was carried out in eight centers and included 191 patients (children and adults) with allergic respiratory disease due to sensitization to olive tree and/or grass pollen. Of these, 34 patients acted as controls and the remaining patients received immunotherapy administered in the initiation phase according to a cluster schedule of eight doses injected on four visits. After 3 months of treatment, significant differences were found between the two groups in medication consumption (antihistamines in drops and oral formulations: p = 0.045 and p = 0.001, respectively; short-acting β2-agonist treatments: p = 0.004) and respiratory symptoms (wheezing and coughing: p = 0.035 and 0.014, respectively). The cytokine profile (interleukin [IL]-4, 5, 10 and 2, interferon [IFN-γ], and tumor necrosis factor [TNF-α]) was determined before the start of treatment and at the end of follow-up (4-5 months). Levels of IL-4, 5 and 10 (Th2 profile) decreased while those of IL-2, IFN-γ, and TNF-α (Th1 profile) decreased. These differences were more marked in the active group than in the control group but were not statistically significant. No severe adverse effects were recorded. This study shows that the schedule tested had an acceptable tolerance profile and produced significant changes in symptom and medication scores after a few months of treatment. A double-blind, placebo-controlled study is needed to confirm these results (AU)


Se ha llevado a cabo un estudio prospectivo y multicéntrico con el objetivo de valorar la tolerancia y posible efecto a corto plazo de las vacunas alergénicas administradas bajo pauta cluster en los meses inmediatamente anteriores al inicio de la estación polínica. El estudio se realizó en 8 centros, incluyéndose un total de 191 pacientes (niños y adultos) con enfermedad alérgica respiratoria por sensibilización a polen de olivo y/o gramíneas. De ellos, 34 actuaron como controles y a los pacientes restantes se les administró inmunoterapia bajo una pauta cluster, en la fase de iniciación, de 8 dosis administradas en 4 visitas. Tras 3 meses de tratamiento, se registraron diferencias significativas entre ambos grupos en el consumo de medicación (antihistamínicos en colirio y orales -p = 0,045 y p = 0,001 respectivamente- y ß2 de corta duración -p = 0,004-) así como en síntomas pulmonares (sibilancias y tos -p = 0,035 y 0,014 respectivamente-). Por otro lado, se determinó el perfil de citocinas (IL-4, 5, 10 y 2, IFN-gamma y TNF-a) de forma previa al inicio del tratamiento y al finalizar el seguimiento (4-5 meses). Se observaron descensos en los niveles de IL-4, 5 y 10 (perfil TH2) y aumento en los valores de IL-2, IFN-gamma y TNF-a (perfil TH1), más marcados en el grupo activo que en el control, sin alcanzar significación estadística. No se registraron efectos adversos severos. Por tanto, podemos observar que la pauta ensayada mostró un adecuado perfil de tolerancia, y tras pocos meses de tratamiento se registraron cambios significativos en la puntuación de síntomas y medicación, siendo necesaria la realización de un estudio con un diseño doble ciego frente a placebo para confirmar los resultados obtenidos (AU)


Assuntos
Humanos , Criança , Adulto , Pessoa de Meia-Idade , Seguimentos , Poaceae , Olea , Dessensibilização Imunológica , Antialérgicos , Agendamento de Consultas , Extratos Vegetais , Terapia Combinada , Citocinas , Alérgenos , Pólen , Estudos Prospectivos , Estações do Ano , Resultado do Tratamento , Agendamento de Consultas , Rinite Alérgica Sazonal
19.
Alergol. inmunol. clín. (Ed. impr.) ; 19(4): 153-159, ago. 2004. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-135186

RESUMO

Antecedentes y objetivos: La alergia es un problema de salud cada vez más importante. Por ello, tiene interés conocer los alérgenos concretos y su distribución en la población. Puesto que las vacunas con extractos hiposensibilizantes constituyen un tratamiento fundamental de este trastorno, mediante el análisis de la composición de los preparado usados se pueden conocer los principales alérgeno que constituyen el problema. Material y métodos: Prescripciones en receta médica oficial del Sistema Nacional de Salud de vacunas antialérgicas realizadas en las tres provincias de Aragón en el año 2001. Resultados: La distribución del número relativo de vacunaciones es muy diferente en la tres provincia . siendo casi el triple en Huesca que en Zaragoza, aunque con una estacionalidad a lo largo del año muy similar. Los tratamientos los inician casi siempre especialistas en alergología. El 44,5% de las vacunas contenían como alérgeno alguna gramínea, seguidas en importancia por las chenopodiáceas, los ácaro , los himenópteros, las oleáceas y las bacterianas. Conclusiones: Las diferencias en la frecuencia de utilización en las tres provincias difícilmente se pueden explicar exclusivamente por las características de la población, y es posible que influyan también los recursos y la organización del sistema asistencial. A pesar del papel destacado que tienen los tratamientos con extracto de pólenes de gramíneas, sus asociaciones no parecen estar estandarizada ni homologadas, sino que son diferentes en cada presentación comercial, por lo que el enfoque terapéutico resulta demasiado empírico y poco preciso. Parece necesaria la puesta en común de los criterios de actuación de los servicios de alergología de nuestra comunidad (AU)


Background and objectives: The allergy represents a health problem of increasing importance. Therefore, the knowledge of the particular allergen and it distribution over the population is interesting. Since the vaccines containing immunotherapic extracts are one basic treatment for this pathology, through the analysis of the composition of the preparations used it's possible to know the main allergens representing the problem. Material and methods: Prescriptions of antiallergenic vaccines made by the doctor of the Spain's National Health System in the three provinces of Aragon along the year 200 l. Results: The distribution of the relative arnount of vaccination is very different in the three province . being nearly three times in Huesca in comparison with Zaragoza, though with a very similar easonal nature along the year. The treatment are usually initiated by allergologists. The 44,5% of the total vaccines contained sorne gramineae, followed in importance by chenopod diseaceae. mires, hymenoptera. oleaceae and preparations of bacteria. Conclusions: It' difficult to explain the difference in the rate of use in the three province only by the characteritic of the population, being probable the influence of the resources and the organization of the health care system. In despite of the prominent role of the treatment with preparations containing gramineae pollens, its association don 't seem to be standardized or homologated. they are different in each commercial preparation: thats why the focusing of this therapy results too ernpirical and scarcely precise. It seems necessary a consensus in the profesional criteria of the unit of Allergology in our Community (AU)


Assuntos
Humanos , Imunoterapia/métodos , Hipersensibilidade Respiratória/terapia , Dessensibilização Imunológica/métodos , Pyroglyphidae , Ácaros , Pólen , Rinite Alérgica Sazonal/terapia , Poaceae/efeitos adversos
20.
Allergol. immunopatol ; 32(3): 121-124, mayo 2004. ilus
Artigo em Espanhol | IBECS | ID: ibc-144044

RESUMO

Los alergenos de los pólenes que desencadenan rinoconjuntivitis y/o asma, corresponden a los procedentes de los árboles y plantas que polinizan a través del aire (polinización anemófila) y no a través de los insectos (polinización entomófila). A pesar de que el tamaño de los granos de polen es aparentemente muy grande como para poder alcanzar con facilidad las vías aéreas intrapulmonares, la relación existente entre las concentraciones de pólenes y la presencia de síntomas de asma es mas que evidente. Esto es probablemente debido a que los alergenos inductores de asma estacional no sólo se encuentran dentro de los granos de polen, si no también fuera de los mismos en partículas inferiores a 10 m que se encuentran libres en la atmósfera. Los pólenes mas importantes productores de polinosis en España son los procedentes de los cipreses en enero-marzo, el abedul en abril (macizo galaico), Platanus hispanica (marzo-abril), las gramíneas y olivo en abril-junio, la Parietaria de abril-julio y el Chenopodium y/o Salsola de julio-septiembre. Por áreas geográficas la primera causa de polinosis son las gramíneas en el Centro y Norte de la península, el olivo en el Sur (Jaén, Sevilla, Granada, Córdoba) y la Parietaria en las regiones costeras mediterráneas (Barcelona, Murcia, Valencia) (AU)


Allergenic pollens that cause rhinoconjuctivitis and/or asthma are those from trees or plants that pollinate through the air (anemophilic pollination) and not through insects (entomophilic pollination). Although pollen grains would seem to be too large to easily reach the intrapulmonary airways, the relationship between pollen counts and the presence of asthmatic symptoms is only too evident. This is probably because the allergens inducing seasonal asthma are not only found within pollen grains but also outside the grains in particles of less than 10 m that are freely found in the atmosphere. The most important pollens producing pollinosis in Spain are those from cypress trees from JanuaryMarch, birch trees in April (macizo galaico), Platanus hispanica (March-April), grasses and olive trees from April-June, Parietaria from April-July and Chenopodium and/or Salsola from July-September. By geographical areas, the main cause of pollinosis are grasses in the center and north of the peninsula, olive trees in the south (Jaén, Sevilla, Granada, Córdoba) and Parietaria in the Mediterranean coast (Barcelona, Murcia, Valencia) (AU)


Assuntos
Humanos , Alérgenos/efeitos adversos , Pólen , Rinite Alérgica Sazonal/etiologia , Árvores , Alérgenos/imunologia , Clima , Poaceae , Pólen/imunologia , Rinite Alérgica Sazonal/epidemiologia , Estações do Ano , Espanha/epidemiologia
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