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1.
Eur. j. anat ; 22(6): 449-459, nov. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-182112

RESUMO

The aim of this work was to elucidate a possible protective role of Rumex vesicarius L. (RV) against malathion (MT)-induced hepatotoxicity in adult male albino rats. Forty-eight adult male albino rats were divided into three groups: Group I (control group), 12 rats, divided into two equal subgroups: subgroup Ia received a single intraperitoneal (ip) dose of ½ ml corn oil. Subgroup Ib received oral RV 200 mg/kg daily. Two rats from each subgroup were sacrificed at one day, seven and 28 days. Group II (MT- treated group) 18 rats, each received a single ip dose of 250 mg/kg MT. They were further divided into three equal subgroups: IIa sacrificed at one day, IIb at seven days and IIc at 28 days. Group III (MT plus RV-treated group) 18 rats, each received a single ip dose of MT plus daily RV orally. They were further divided into three equal subgroups: IIIa sacrificed at one day, IIIb at seven days and IIIc at 28 days. Body (BW) and liver weights were recorded and blood samples were collected for Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP). Livers of rats were processed for light and electron microscopic examination.MT administration induced significant decrease in BW and relative liver weights and significant increase in ALT, AST, and ALP levels in addition to histological alterations. Some hepatocytes showed pyknotic nuclei, rarefied, vacuolated, or dark cytoplasm, fat-like droplets with congestion of blood sinusoids and widened space of Disse, appearance of collagenous bundles, abnormal mitochondria with fusion of cytoplasmic organelles in Electron microscopy. Addition of RV to MT in group III significantly improved BW and relative liver weights, biochemical parameters as well as histological picture. MT administration resulted in marked degeneration in the liver that was ameliorated by with concomitant administration of RV


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Assuntos
Animais , Masculino , Adulto , Ratos , Rumex , Extratos Vegetais/uso terapêutico , Malation/toxicidade , Extratos Vegetais/farmacologia , Fígado/anatomia & histologia , Fígado/ultraestrutura
2.
Ars pharm ; 48(4): 361-369, 2007. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-64399

RESUMO

Se evaluó la actividad gastroprotectora de extractos acuosos de 11 plantas que se desarrollan en Argentina: Aloysiagratissima, Artemisia annua, Calendula offi cinalis, Gaillardia megapotamica, Maytenus ilicifolia, Parthenium hysterophorus,Portulaca oleracea, Rumex obtusifolius, Solidago chilensis, Solanum eleagnifolium y Spartium junceum frentea un modelo de úlcera gástrica inducida por etanol en ratones. Los resultados se expresaron en términos de Indicede Ulcera (IU), el cual se estableció de acuerdo a la longitud de las lesiones gástricas. Los ensayos farmacológicosdemostraron que los extractos acuosos de todas las plantas, administrados oralmente, exhibieron una signifi cativaactividad antiulcerosa (P < 0,01). Es sabido que los fl avonoides, entre otros compuestos, poseen reconocidas propiedadesgastroprotectoras. Debido a que algunos de los extractos contienen dichos componentes, parte de la actividadantiulcerosa podría deberse a su presencia. El mecanismo involucrado en este efecto no está totalmente elucidado.Por lo tanto, en una primera etapa, los extractos deberán ser fraccionados y analizados para determinar su modode acción y evaluar adecuadamente la actividad gastroprotectora de estas plantas (AU)


The gastro protective activity of aqueous extracts from 11 plants native to Argentina was evaluated on ethanol-inducedgastric ulcer model in mice: Aloysia gratissima, Artemisia annua, Calendula offi cinalis, Gaillardia megapotamica,Maytenus ilicifolia, Parthenium hysterophorus, Portulaca oleracea, Rumex obtusifolius, Solanum eleagnifolium,Solidago chilensis and Spartium junceum. The results were expressed in terms of an Ulcer Index (UI), based on themeasurement of the length of the gastric lesions produced. Pharmacological assays demonstrated that aqueous extractsfrom all the plants, administered in oral form, showed signifi cant antiulcerogenic activity (P < 0.01). It has already beenestablished that among other compounds, the fl avonoids possess, gastro protective properties. As some of the aqueousextracts contain these constituents, the partial antiulcer activity found could be attributed to their presence. The mechanisminvolved in this effect has not been entirely elucidated and as a fi rst stage in its analysis, extracts should befractionated in order to better determine the role of each component (AU)


Assuntos
Camundongos , Masculino , Animais , Plantas Medicinais/química , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/tratamento farmacológico , Úlcera Péptica/tratamento farmacológico , Artemisia annua/química , 26215/farmacologia , Maytenus/química , Parthenium hysterophorus/análise , Extratos Vegetais/farmacologia , Antiulcerosos/farmacologia , Argentina/epidemiologia , Portulaca/química , Rumex/química , Solidago/química , Spartium/química , Flavonoides/química , Etanol/efeitos adversos
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