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1.
Allergol. immunopatol ; 47(5): 491-498, sept.-oct. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186524

RESUMO

Background: Mendelian susceptibility to mycobacterial disease (MSMD) is characterized by increased susceptibility to weakly virulent mycobacteria (Bacillus Calmette-Guérin [BCG] vaccines and environmental mycobacteria), Mycobacterium tuberculosis, Candida spp. and Salmonella spp. The aim of this study is to evaluate clinical features and immunological findings of MSMD patients with interleukin 12 receptor beta 1 (IL12Rβ1) deficiency. Methods: Among 117 screened patients with BCG infection following vaccination, 23 suspected MSMD subjects were recruited to this study by the exclusion of severe combined immunodeficiencies and chronic granulomatous diseases. Flow cytometric assessment for surface expression of IL12Rβ1 was performed. Moreover, the clinical and immunological data from the patients was evaluated. Results: A significant decrease (less than 1%) in the surface expression of IL12Rβ1 was reported in six cases which showed a significant increase in the count of lymphocytes (p = 0.009) and CD8+ T cells (p = 0.008) as compared to MSMD subjects with normal expression of surface IL12Rβ1. The frequency of disseminated BCGosis (50% vs. 20%, p = 0.29), recurrent infection (83.3% vs. 40%, p = 0.14) and salmonellosis (33.3% vs. 0.0%, p = 0.07) was higher in IL12Rβ1 deficient subjects than IL12Rβ1 sufficient individuals. Conclusion: MSMD patients with childhood onset of mycobacteriosis (mostly after BCG vaccination) and recurrent salmonellosis could be evaluated for IL12Rβ1 expression with flow cytometry for punctual diagnosis


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Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adolescente , Herpes Simples/imunologia , Síndromes de Imunodeficiência/imunologia , Mutação/genética , Mycobacterium bovis/imunologia , Infecções por Mycobacterium não Tuberculosas/imunologia , Simplexvirus/fisiologia , Receptores de Interleucina-12/genética , Predisposição Genética para Doença , Herpes Simples/genética , Síndromes de Imunodeficiência/genética , Infecções por Mycobacterium não Tuberculosas/genética , Estudos Prospectivos , Receptores de Interleucina-12/metabolismo
3.
Psiquiatr. biol. (Internet) ; 26(1): 38-40, ene.-abr. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-185026

RESUMO

Clásicamente la epilepsia y la depresión se han visto estudiadas y relacionadas. Esta correlación se traduce en la práctica clínica con una elevada incidencia de comorbilidades psiquiátricas en los pacientes diagnosticados de epilepsia, en especial con los trastornos afectivos unipolares. A su vez, ambas entidades se han observado como secuela medio-tardía tras encefalitis por virus herpes simple (VHS). Se presenta el caso clínico de un varón de 30 años diagnosticado de depresión mayor recurrente de aparición tras un episodio de encefalitis vírica por VHS-1 a los 16 años de edad. Tras varios cambios y combinaciones de fármacos antidepresivos se objetiva una respuesta satisfactoria al tratamiento con ISRS y lamotrigina


The link between epilepsy and depression has been studied and confirmed by many papers. This correlation has its clinical importance given the high incidence of psychiatric comorbidities commonly found in patients diagnosticated of epilepsy, particularly unipolar affective disorder. Both pathologies are also described as a medium-long term sequelae of HSV encephalitis. In this case report, the diagnosis of major depression in a 30-year old man who undergoes HSV-1 encephalitis is analyzed. After many switches of antidepressant treatment, the combination of Lamotrigine and SNRIs turned out to be the most successful


Assuntos
Humanos , Masculino , Adulto , Encefalite/complicações , Epilepsia/complicações , Transtorno Depressivo Maior/psicologia , Viroses do Sistema Nervoso Central/complicações , Antidepressivos/uso terapêutico , Lamotrigina/uso terapêutico , Simplexvirus/patogenicidade , Transtornos do Humor/psicologia
4.
Med. clín (Ed. impr.) ; 151(2): 71-79, jul. 2018. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-173777

RESUMO

La encefalitis asociada a anticuerpos contra el receptor N-metil-D-aspartato (NMDAR) se caracteriza por la presencia de anticuerpos contra la subunidad GluN1 del NMDAR, resultando en síntomas parecidos a los observados en modelos de alteración genética o antagonistas farmacológicos del receptor. Los pacientes suelen ser adultos jóvenes, predominantemente mujeres, y niños/as que presentan de manera rápida y secuencial: psicosis, movimientos anormales, disfunción autonómica y coma. Las crisis epilépticas son variables y pueden ocurrir en cualquier momento de la evolución. La enfermedad suele confundirse con encefalitis virales, procesos psiquiátricos primarios, ingesta de drogas y síndrome neuroléptico maligno. El 50% de las mujeres jóvenes tienen un teratoma de ovario; en niñas y varones, la presencia de un tumor es infrecuente. En algunos pacientes la enfermedad es iniciada por una encefalitis herpética. El reconocimiento de la encefalitis anti-NMDAR es importante porque, a pesar de su gravedad, la mayoría de los pacientes responden a la inmunoterapia


The encephalitis associated with antibodies against the N-methyl-D-aspartate receptor (NMDAR) is characterized by the presence of antibodies against the GluN1 subunit of this receptor, resulting in symptoms that are similar to those observed in models of genetic or pharmacologic reduction of NMDARs. Patients are usually young adults, predominantly women, and children who develop, in a sequential manner, rapidly progressive symptoms including psychosis, abnormal movements, autonomic dysfunction, and coma. Epileptic seizures are variable and can occur throughout the course of the disease. The disease is often mistaken as viral encephalitis, primary psychiatric disorders, drug abuse, or neuroleptic malignant syndrome. About 50% of young women have an ovarian teratoma; in young girls and men the presence of a tumour is infrequent. In some patients, the disease is triggered by herpes simplex encephalitis. The recognition of anti-NMDAR encephalitis is important because, despite its severity, most patients respond to immunotherapy


Assuntos
Humanos , Encefalite Antirreceptor de N-Metil-D-Aspartato/diagnóstico , Encefalite Antirreceptor de N-Metil-D-Aspartato/tratamento farmacológico , Encefalite Antirreceptor de N-Metil-D-Aspartato/epidemiologia , Diagnóstico Diferencial , Encéfalo/fisiopatologia , Prognóstico , Simplexvirus , Metilprednisolona/administração & dosagem
12.
Rev. esp. pediatr. (Ed. impr.) ; 70(1): 8-11, ene.-feb. 2014.
Artigo em Espanhol | IBECS | ID: ibc-121766

RESUMO

La erupción variceliforme de Kaposi o eccema herpético es una erupción vesicular causada, habitualmente, por la extensión de un virus (normalmente, el virus herpes simple tipo I o VHS-1) en pacientes con enfermedades subyacentes de la piel o alteración de la barrera epidérmica, principalmente dermatitis atópica. Es un proceso más o menos grave, que requiere un diagnóstico precoz y que responde bien al tratamiento (AU)


Kaposi's varicelliform eruption or Eczema herpeticum is an extensive vesicular rash commonly caused by the spread of a virus (usually herpes simplex virus type 1 or HSV-1) in patients with underlying diseases of the skin or epidermal barrier disruption, mainly atopic dermtitis. It is a more or less serious process, which requires an early diagnosis and which responds well to treatment (AU)


Assuntos
Humanos , Erupção Variceliforme de Kaposi/diagnóstico , Dermatite Atópica/complicações , Simplexvirus/patogenicidade , Antivirais/uso terapêutico , Aciclovir/uso terapêutico , Cloxacilina/uso terapêutico , Sulfato de Zinco/uso terapêutico
16.
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 30(7): 361-366, sept. 2012. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-104131

RESUMO

Objetivos: El estudio describe las características clínicoepidemiológicas y la etiología de la meningitis aséptica aguda (MAA) y analiza el impacto de un resultado microbiológico en el manejo clínico del paciente. Pacientes y métodos Se incluyeron prospectivamente en el estudio los pacientes mayores de 14 años inmunocompetentes con un cuadro clínico compatible con MAA entre 2007 y 2010. Se investigó la presencia de enterovirus y herpesvirus en líquido cefalorraquídeo por técnicas de amplificación genómica. Se recogieron retrospectivamente los datos clinicoepidemiológicos. Resultados Se incluyeron 94 pacientes, de los que 84 se diagnosticaron de meningitis vírica (MV). La incidencia anual de MV varió desde 2,4 a 15,3 casos por 100.000 habitantes. En el 76,2% de los casos se diagnosticó un agente etiológico; 55 enterovirus, 4 VHS tipo 2, 3 VVZ, un VHS tipo 1 y un VEB. Un 45,2% de los pacientes ingresaron y el 65,8% de ellos recibieron tratamiento antibiótico. El 80% de los pacientes ingresados recibió el alta al informar de un resultado positivo y en el 94,1% se retiró el tratamiento antibiótico. El tiempo medio de hospitalización en estos pacientes fue de 2,8±2,9 días. Todos los pacientes sin resultado positivo durante el ingreso completaron el tratamiento antibiótico, y el tiempo medio de hospitalización fue de 11,6±4,6 días. Conclusione s La incidencia anual de la MAA es variable. Los enterovirus fueron los principales agentes etiológicos. Las pruebas moleculares permitieron el diagnóstico en el 76,2% de los casos. El 45,2% de los pacientes ingresaron y un resultado positivo permitió el alta en la mayoría de los casos, así como la retirada del tratamiento antibiótico (AU)


Objective: This study describes the epidemiological, clinical and microbiological features of acute aseptic meningitis (AAM) in an adult population, and evaluates the impact of microbiological results on the clinical management of patients. Patients and methods: Cases of AAM were prospectively collected between 2007 and 2010 among immunocompetent patients over 14 years-old. Enteroviruses and herpes viruses were determined using nucleicacids detection in CSF. Demographic and clinical data were retrospectively collected from medicalrecords. Results: A total of 94 patients were included, of whom 84 were diagnosed with viral meningitis (VM). The annual incidence of VM ranged from 2.4 to 15.3 cases per 100,000 inhabitants. An aetiological diagnosiswas obtained in 76.2% of the patients with VM, 55 enterovirus, 4 HSV-2, 3 VZV, one HSV-1, and one EBV. Forty (..) (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Meningite Asséptica/epidemiologia , Técnicas de Diagnóstico Molecular/métodos , Meningite Viral/epidemiologia , Enterovirus/isolamento & purificação , Simplexvirus/isolamento & purificação
17.
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 30(supl.2): 63-69, mar. 2012. tab
Artigo em Inglês | IBECS | ID: ibc-105878

RESUMO

Despite great advances in solid organ transplantation (SOT) in recent decades, infection remains a major cause of morbidity and mortality among SOT recipients. Members of the herpesvirus family are the most common viral pathogens causing disease in this patient population. Herpes viruses are large enveloped DNA viruses that commonly reactivate during periods of severe immunosuppression. Currently, infections caused by herpes viruses continue to complicate clinical management of transplant patients. Although cytomegalovirus (CMV) is the most important virus of this family and is the subject of active research, herpes simplex virus (HSV) and varicella-zoster virus (VZV) can also lead to severe disease. Epstein-Barr virus (EBV) associated with post-transplant lymphoproliferative disease is increasingly recognized as a major complication of SOT. There is less information available on the role and impact of other viruses of the herpesvirus family, such as the human herpes virus 6 (HHV-6), human herpes virus 7 (HHV-7) and human herpes virus 8 (HHV-8). This review summarizes current knowledge regarding epidemiology, clinical manifestations, diagnosis, treatment and prevention of infections caused by herpes viruses other than CMV in SOT recipients (AU)


A pesar de los grandes avances en el trasplante de órgano sólido (TOS) en las últimas décadas, la infección sigue siendo la mayor causa de morbimortalidad entre los receptores de TOS. Los miembros de la familia herpes virus son los patógenos virales más frecuentes causantes de enfermedad en esta población de pacientes. Los herpesvirus son virus ADN grandes envueltos, que habitualmente se reactivan durante períodos de inmunodepresión grave. Actualmente, las infecciones causadas por herpesvirus continúan siendo un desafío para el tratamiento clínico de los pacientes trasplantados. Aunque el citomegalovirus (CMV) es el virus más importante de esta familia y sobre el que se realiza una investigación activa, el virus herpes simple (VHS) y el virus varicela-zoster (VVZ) pueden también producir una enfermedad grave. La enfermedad linfoproliferativa asociada al virus de Epstein-Barr (VEB) se reconoce cada vez más como una complicación importante del TOS. Existe menos información disponible sobre el papel y el impacto de otros virus de la familia de los herpesvirus, como por ejemplo el virus del herpes humano 6 (VHH-6) y el virus del herpes humano 8 (VHH-8). Esta revisión resume el conocimiento actual respecto a la epidemiología, las manifestaciones clínicas, diagnóstico, tratamiento y prevención de las infecciones causadas por otros herpesvirus distintos al CMV en receptores de TOS (AU)


Assuntos
Humanos , Transplante de Órgãos/efeitos adversos , Infecções por Herpesviridae/complicações , Herpesviridae/patogenicidade , Herpesvirus Humano 3/patogenicidade , Simplexvirus/patogenicidade , Herpesvirus Humano 4/patogenicidade
18.
Med. oral patol. oral cir. bucal (Internet) ; 16(2): 163-169, mar. 2011. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-92979

RESUMO

Objectives. To revise the clinical features of the recurrent intraoral herpetic infection (RIOH) with respect to precipitatingfactors, demographic, clinical features and outcome.Study design. Fifty-eight, unrelated Caucasian, immunocompetent patients with positive laboratory test for intraoralHerpes simplex virus infection were studied.Results. The mean age in the women’s group (n=42) was 41.23 years (± 21.73) and in the men’s group was 32.25years (± 15.68). Possible trigger factors were identified in 9 cases (15.5%). General symptoms were noted in 20cases (34.48%). Most of patients in this study presented multiple lesions. 14 patients had vermillion lesions associatedwith intraoral lesions. In most of the cases both fixed and mobile mucosa was concomitantly involved. Treatmentwas prescribed in order to control the symptoms and to shorten the evolution with minimal side effects.Conclusions. Intraoral secondary herpetic infection could be polymorphous and sometimes associated with generalsymptoms. The recognition of its atypical features may prevent unnecessary and costly investigations andtreatments for unrelated though clinically similar-appearing disorders (AU)


Assuntos
Humanos , Estomatite Herpética/epidemiologia , Simplexvirus/isolamento & purificação , Distribuição por Idade e Sexo , Recidiva , Antivirais/uso terapêutico , Estudos Retrospectivos
19.
Med. oral patol. oral cir. bucal (Internet) ; 16(2): 170-174, mar. 2011. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-92980

RESUMO

Objectives: The aim of the present study was to assess the prevalence of Herpes Simplex virus, Epstein Barr virusand Human Papilloma virus -16 in oral lichen planus cases and to evaluate whether any clinical variant, histopathologicalor demographic feature correlates with these viruses.Study Design: The study was conducted on 65 cases. Viruses were detected immunohistochemically. We evaluatedthe histopathological and demographic features and statistically analysed correlation of these features withHerpes Simplex virus, Epstein Barr virus and Human Papilloma virus-16 positivity.Results: Herpes Simplex virus was positive in six (9%) cases and this was not statistically significant. The numberof Epstein Barr virus positive cases was 23 (35%) and it was statistically significant. Human Papilloma viruspositivity in 14 cases (21%) was statistically significant. Except basal cell degeneration in Herpes Simplex viruspositive cases, we did not observe any significant correlation between virus positivity and demographic or histopathologicalfeatures. However an increased risk of Epstein Barr virus and Human Papilloma virus infection wasnoted in oral lichen planus cases. Conclusions: Taking into account the oncogenic potential of both viruses, orallichen planus cases should be detected for the presence of these viruses (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Líquen Plano Bucal/complicações , Estomatite Herpética/epidemiologia , Infecções por Vírus Epstein-Barr/epidemiologia , Infecções por Papillomavirus/epidemiologia , Simplexvirus/isolamento & purificação , Herpesvirus Humano 4/isolamento & purificação , Papillomaviridae/isolamento & purificação
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