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3.
Rev. esp. cir. oral maxilofac ; 40(3): 120-128, jul.-sept. 2018. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-177304

RESUMO

Objetivo: El objetivo de este artículo es presentar 3 casos de mixoma odontogénico (MO), un caso de fibromixoma (FM) y una revisión sistemática de la literatura de MO y FM, enfocándonos especialmente en la epidemiología y tratamiento. Métodos: Se revisan todos los casos de MO y FM tratados en nuestro hospital. Se buscó en la base de datos de PubMed utilizando las palabras clave MESH: mixoma odontogénico, mixofibroma odontogénico, fibromixoma odontogénico, desde enero del año 2010 hasta octubre del 2016. Resultados: Se presentan 4 casos clínicos intervenidos en nuestro servicio. Tres de ellos se resecaron y fueron reconstruidos con colgajo de peroné, en el otro se realizó legrado; ninguno presentó recidiva. De los 281 estudios iniciales identificados en PubMed, solo 24 cumplieron con los criterios de inclusión de nuestra investigación; la edad media de los pacientes fue de 32,6 años, eran mujeres el 59%, la localización fue mandibular posterior en el 54% de los casos y hubo recidiva solo en un caso. Para FM identificamos 5 artículos, de los cuales el 50% eran mujeres con una edad media de 16,5 años; el 80% fueron tratados con enucleación y legrado, sin recurrencia. Conclusión: El MO es un tumor poco frecuente, con una variante llamada FM aún más infrecuente y que no es tan recidivante como se describe. La elección de tratamiento depende de ciertas variables como son la localización, la edad del paciente y las necesidades reconstructivas


Purpose: The aim of this work is to report 3 cases of odontogenic myxoma (OM), one case of fibromyxoma (FM), and a review of the literature as regards the epidemiology and treatment of OM and FM. Methods: A study was conducted on all cases of OM and FM treated in our hospital. A search was made in PubMed database using the MESH keywords: «odontogenic myxoma» «odontogenic myxofibroma», «odontogenic fibromyxoma», from January 2010 to October 2016. Results: Of the 4 cases managed in our hospital, 3 of them were resected and reconstructed with fibula flap, and the other one was managed by legrado, with no recurrences. From the first 281 initial papers identified in PubMed, only 24 fulfilled the inclusion criteria of our study. The mean age of patients was 32.6 years, of whom 59% were women, and with posterior mandibular localitation in 54% of the cases and occurrence in only one case. As regards FM, 5 articles were identified in which 50% were women with a mean age of 16.5 years, and 80% were treated by enucleation and legrado with no recurrences. Conclusions: OM is a rare tumour, with a variant called FM that is less common and not as recurrent as described. The choice of treatment should depend on variables such as location, age, and the aesthetic needs of the patient


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Fibroma/cirurgia , Tumores Odontogênicos/cirurgia , Mixoma/cirurgia , Tumores Odontogênicos/patologia , Mixoma/patologia , Fibroma/patologia , Radiografia Panorâmica , Neoplasias Mandibulares/patologia
6.
Med. oral patol. oral cir. bucal (Internet) ; 23(3): e315-e319, mayo 2018. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-175883

RESUMO

Background: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANK-L / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives: To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and Methods: Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANK-L and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results: There are significant differences in the expression of RANK in OM samples as compared to DF (p= 0.022) and among the OMSs and OMLs (p= 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions: Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas


No disponible


Assuntos
Mixoma/metabolismo , Mixoma/patologia , Tumores Odontogênicos/metabolismo , Tumores Odontogênicos/patologia , Osteogênese , Ligante RANK/biossíntese , Receptor Ativador de Fator Nuclear kappa-B/biossíntese , Carga Tumoral
8.
Endocrinol. diabetes nutr. (Ed. impr.) ; 65(1): 52-59, ene. 2018. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-171915

RESUMO

El complejo de Carney es un síndrome de neoplasia múltiple de tumores endocrinos y no endocrinos, que incluye la presencia de mixoma, lentiginosis cutánea y enfermedad nodular primaria pigmentada, entre otros criterios para el diagnóstico. En la mayoría de los casos es de transmisión autosómica dominante, por lo que su diagnóstico hace necesario el estudio y seguimiento familiar. Se ha identificado la presencia de mutaciones inactivantes del gen PRKAR1A como causante de la enfermedad. Desde el año 2015 se han agregado otros genes relacionados, como variantes activantes del gen PRKACA y PRKACB. En este trabajo se ahondará en los aspectos genéticos relacionadas con el complejo de Carney (AU)


Carney complex is a multiple neoplasia syndrome having endocrine and non-endocrine manifestations. Diagnostic criteria include myxoma, lentigines, and primary pigmented nodular adrenocortical disease, amongst other signs/symptoms. In most cases it is an autosomal dominant disease, and diagnosis therefore requires study and follow-up of the family members. Inactivating mutations of the PRKAR1A gene were identified as the main cause of the disease, although since 2015 other disease-related genes, including PRKACA and PRKACB activating mutations, have also been related with Carney complex. This review will address the genetic aspects related to Carney complex (AU)


Assuntos
Humanos , Masculino , Feminino , Complexo de Carney/diagnóstico , Complexo de Carney/genética , Mixoma/complicações , Transcrição Genética/genética , Complexo de Carney/complicações , Doença de Paget Mamária/epidemiologia
13.
Rev. int. androl. (Internet) ; 15(3): 119-122, jul.-sept. 2017. ilus
Artigo em Espanhol | IBECS | ID: ibc-164829

RESUMO

Presentamos el caso y la evolución de un paciente obeso mórbido con antecedentes de dermolipectomía que acudió al Servicio de Urología por iniciativa propia a raíz un cuadro clínico de aumento de volumen escrotal que simulaba un linfedema escrotal con pene umbilicado. Después de realizar los estudios complementarios se asocia el cuadro clínico a los antecedentes quirúrgicos y se decide realizar la exéresis del tejido afecto y una cirugía reparadora junto con el servicio de Cirugía Plástica. El informe de Anatomía Patológica describe un angiomixoma benigno. En este contexto exponemos el caso de un paciente diagnosticado de linfedema escrotal que escondía un angiomixoma (AU)


We report the evolution of a morbidly obese patient with a history of dermolipectomy who attended the Urology Department because of an enlargement of the scrotum and penis. After performing additional studies, the cause is attributed to his surgical history and it was decided to perform the excision of the affected tissue and a reconstructive surgery. The pathology report revealed a benign angiomyxoma. In this context we describe the case of a patient diagnosed with scrotal lymphedema that hid a angiomyxoma (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Linfedema/cirurgia , Linfedema , Mixoma/cirurgia , Mixoma , Elefantíase/complicações , Elefantíase/diagnóstico , Escroto/patologia , Escroto/cirurgia , Escroto , Obesidade Mórbida/complicações , Obesidade Mórbida/diagnóstico , Patologia/métodos , Tela Subcutânea/patologia , Tela Subcutânea , Tomografia com Microscopia Eletrônica
15.
Prog. obstet. ginecol. (Ed. impr.) ; 60(4): 351-354, jul.-ago. 2017. ilus
Artigo em Espanhol | IBECS | ID: ibc-165801

RESUMO

El angiomixoma vulvar agresivo es una neoplasia benigna dérmica y subcutánea, infrecuente. Su localización más frecuente es la zona pélvica y/o genital. Presenta un crecimiento lento y alto índice de recidiva, aunque sin potencial metastático. Su incidencia es muy baja, habiéndose recogido en la literatura 250 casos a nivel mundial. El diagnóstico definitivo se basa en el estudio histológico e inmunohistoquímico. El tratamiento deberá ser quirúrgico mediante resección amplia, siendo el objetivo extirpar por completo la lesión con bordes libres de enfermedad. Presentamos un caso de angiomixoma agresivo de localización vulvar de una mujer de 35 años atendido en nuestro centro hospitalario (AU)


The aggressive angiomyxoma of the vulva is a dermal and subcutaneous rare benign neoplasm. Its most common location is the pelvic and/or genital area. It presents slow growth and high rate of relapse, although no metastatic potential. Its incidence is very low, 250 cases have been collected out of the world literature. The definitive diagnosis is based on histological and immunohistochemical study. A wide local resection should be the surgical treatment as to completely remove the diseased tissue with cleanmargins. We report the case of a 35-year-old woman affected by an aggressive angiomyxoma of the vulva who has been treated at our hospital (AU)


Assuntos
Humanos , Feminino , Adulto , Mixoma/diagnóstico , Mixoma/cirurgia , Neoplasias Vulvares/diagnóstico , Neoplasias Vulvares/cirurgia , Imuno-Histoquímica/métodos , Laparoscopia/métodos , Vulva/anatomia & histologia , Vulva/cirurgia , Procedimentos Cirúrgicos em Ginecologia/métodos , Vulva
20.
Prog. obstet. ginecol. (Ed. impr.) ; 60(2): 136-139, mar.-abr. 2017. ilus
Artigo em Espanhol | IBECS | ID: ibc-164054

RESUMO

Los tumores cardíacos primarios son entidades de rara aparición. Un 50% son mixomas y aparecen en adultos (edad media 56 años) y principalmente en mujeres. Presentamos un caso de un mixoma auricular diagnosticado en una paciente de 25 años de edad durante el segundo trimestre de la gestación. El tratamiento de elección es la exéresis quirúrgica, que en este caso fue realizada tras finalización de la gestación en la semana 35 de amenorrea (AU)


Primary cardiac tumors are rare appearance entities. 50% are myxomas and appear in adults (mean age 56 years) and especially in women. We report a case of atrial myxoma diagnosed in a 25 years old during the second trimester of pregnancy. The treatment of choice is surgical excision, which in this case was made after completion of pregnancy in week 35 of amenorrhea (AU)


Assuntos
Humanos , Feminino , Gravidez , Adulto , Complicações na Gravidez/fisiopatologia , Mixoma/cirurgia , Mixoma , Arritmia Sinusal/complicações , Arritmia Sinusal , Cirurgia Torácica/métodos , Segundo Trimestre da Gravidez , Amenorreia/terapia , Ecocardiografia , Osteogênese Imperfeita/genética , Eletrocardiografia , Neoplasias Cardíacas , Procedimentos Cirúrgicos Cardíacos/métodos
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