Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 124
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Intervalo de ano de publicação
1.
Cient. dent. (Ed. impr.) ; 17(1): 35-40, ene.-abr. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-189747

RESUMO

Los implantes dentales constituyen una alternativa predecible para la rehabilitación de los maxilares edéntulos, sin embargo, el éxito del tratamiento puede ver-se comprometido cuando existen graves atrofias maxilares. Para el tratamiento de estos casos complejos, se han desarrolla-do técnicas de regeneración ósea, entre las que destacan la regeneración ósea guiada y los injertos en bloque. Dentro de estos últimos, cabe destacar la técnica de Khoury. Se trata de un procedimiento indicado para regenerar defectos horizontales y verticales, mediante la obtención de finas láminas de hueso autógeno procedentes de la línea oblicua externa mandibular. Se presenta un caso clínico de un gran defecto mandibular reconstruido con la técnica de Khoury, secundario a un fracaso implantológico que además ocasionó patología nerviosa


Dental implants constitute a predictable alternative for the rehabilitation of edentulous jaws. However, the success of the treatment can be limited when severe atrophic alveolar ridges are present. For the treatment of these complex cases, several regeneration techniques have been developed, such as guided bone regeneration and block grafts. Within the last, it should be noted the Khoury technique. It is a procedure indicated for the regeneration of horizontal and vertical defects, through the obtention of autologous graft in form of thin plates, derived from mandibular external oblique line.A clinical case is presented, that consists in a great mandibular defect which was reconstructed by the Khoury technique. The defect was secondary to an implant failure, which was also related with nervous pathology


Assuntos
Humanos , Masculino , Idoso , Regeneração Óssea , Atrofia/cirurgia , Hipestesia/cirurgia , Falha de Restauração Dentária , Maxila/cirurgia , Levantamento do Assoalho do Seio Maxilar/métodos , Procedimentos Cirúrgicos Reconstrutivos/métodos , Implantes Dentários , Reabsorção Óssea/patologia , Boca Edêntula/cirurgia
2.
Eur. j. anat ; 23(6): 435-446, nov. 2019. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-185086

RESUMO

Thorough knowledge of the variation of intrahepatic course of the portal vein is essential for pre-operative assessment of various hepatic surgeries like hepatectomy and live donor liver transplant. This study aims to determine the variation in the branching pattern of the portal vein in South Indian population. The branching pattern of the portal vein was studied by 3D reconstruction of 100 contrast-enhanced computed tomography images and in 15 formalin fixed livers using modified luminal casting technique. Radiologically, the normal portal vein anatomy was seen in 89%. The most common variation was trifurcation of portal vein (5%). A rare anomaly was noted in one case where the left portal vein gave a branch to segment VII. Using the modified luminal casting technique all the 15 specimens displayed Type I portal vein anatomy. The most common variation in the intrahepatic branching pattern observed was the right posterior segmental division supplying segment VIII. A rare left portal vein variation, in which it gave branches to segments V and VIII was noted. In this study, variations in the segmental supply of the portal vein were observed, which have not been studied in detail previously in the Indian population. Variations on the left portal vein are infrequent. A prior knowledge of such variations will help the interventional radiologists to reduce misinterpretations and subsequent misdiagnosis and guide the hepatobiliary


No disponible


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Nervo Facial/anatomia & histologia , Nervo Facial/diagnóstico por imagem , Orelha Média/anatomia & histologia , Dissecação/métodos , Cadáver , Osso Temporal/anatomia & histologia , Deiscência da Ferida Operatória/diagnóstico por imagem , Orelha Média/diagnóstico por imagem , Anatomia/educação , Reabsorção Óssea/patologia
3.
Actas dermo-sifiliogr. (Ed. impr.) ; 110(8): 642-652, oct. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-185502

RESUMO

La psoriasis es un proceso inflamatorio crónico que se ha asociado con múltiples comorbilidades, especialmente las formas más graves y asociadas a artritis. El estado de inflamación sistémica es, probablemente, la conexión entre todas estas enfermedades concomitantes. Algunos trabajos recientes indican que los pacientes con psoriasis pueden tener mayor riesgo de fracturas patológicas y osteoporosis. Las guías actuales de abordaje de las comorbilidades de la psoriasis no incluyen valoración de la salud del hueso. Por eso, en este artículo nos proponemos revisar la evidencia disponible sobre la relación entre psoriasis y osteoporosis. Repasaremos primero el concepto de osteoporosis, abordaremos también el papel de la vitamina D en el hueso y, por último, proponemos un algoritmo de manejo y tratamiento de la osteoporosis en el paciente con psoriasis


Psoriasis is a chronic inflammatory disease associated with multiple comorbidities, particularly in patients with arthritis or more severe forms of the disease. The link between all these comorbidities is probably systemic inflammation. Several recent studies have indicated that patients with psoriasis may be at an increased risk of pathologic fractures and osteoporosis. Current guidelines on comorbidities in psoriasis do not recommend assessment of bone health. In this article, we review the available evidence on the association between psoriasis and osteoporosis. We first examine the concept of osteoporosis and the role of vitamin D in bone health and then propose an algorithm for managing and treating this condition in patients with psoriasis


Assuntos
Humanos , Osteoporose/epidemiologia , Fatores de Risco , Qualidade de Vida , Psoríase/complicações , Fraturas Ósseas/complicações , Osteoporose/complicações , Densitometria/métodos , Índice de Massa Corporal , Indicadores Básicos de Saúde , Reabsorção Óssea/patologia , Deficiência de Vitamina D/complicações
4.
Rev. osteoporos. metab. miner. (Internet) ; 11(1): 19-24, mar. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-184081

RESUMO

Objetivo: Se estima que al año entre el 50-60% de los pacientes tratados con fármacos para la osteoporosis son incumplidores. Disponemos de diferentes métodos indirectos de valoración del cumplimiento. Nuestro objetivo es testar una única determinación del telopéptido carboxiterminal del colágeno tipo I (CTX) para valorar el cumplimiento en pacientes tratadas con bifosfonatos, de forma aislada o junto al cuestionario de Morinsky-Green. Material y método: Estudio de validación diagnóstica realizado en 10 centros de Cataluña. Mediante muestreo consecutivo se seleccionaron mujeres postmenopáusicas con osteoporosis y tratadas con un mismo fármaco antirresortivo en el último año; se excluyeron aquellas tratadas con un fármaco diferente a bifosfonato, con deterioro cognitivo, enfermedad terminal, o insuficiencia renal avanzada, o fractura en el año previo. Se recogieron datos sobre el diagnóstico de osteoporosis y tipo de tratamiento. Se solicitó analítica con determinación del CTX. Como gold-standard se utilizó la tasa de posesión de medicación (Medication Possession Ratio, MPR). Mediante metodología de la curva ROC se estableció el punto de corte teórico del CTX. Se calculó la sensibilidad, la especificidad y los valores predictivos positivos para estimar el cumplimiento terapéutico. Resultados: Se incluyeron 100 pacientes, de las cuales más de la mitad recibían alendronato. Según la MPR, un 70% eran cumplidoras. El valor medio del CTX fue de 0,193±0,146 ng/ml, siendo inferior en las pacientes cumplidoras. Se estableció como punto de corte para valorar el cumplimiento un valor de 0,196 ng/ml. La valoración conjunta del CTX junto al cuestionario de Morinsky-Green presentó mayor capacidad discriminativa. Conclusiones: La realización de una única determinación del CTX (<0,196 ng/ml) junto al cuestionario de Morinsky-Green permite valorar mejor el cumplimiento terapéutico en pacientes tratadas con bifosfonatos


Objective:It is estimated that in one year between 50‐60% of patients treated with osteoporosis drugs are non‐com‐pliant. There are different indirect methods of assessing compliance. Our objective is to test a single determination ofthe carboxyterminal telopeptide of type I collagen (CTX) to assess compliance in patients treated with bisphosphonates,either on its own or together with the Morinsky‐Green questionnaire.Material and method:A diagnostic assessment study was carried out in 10 centers in Catalonia. Through consecutivesampling, postmenopausal women with osteoporosis were selected and treated with the same antiresorptive drug inthe last year. Those treated with a drug other than bisphosphonate, with cognitive impairment, terminal illness, advancedrenal failure or fracture in the previous year, were excluded. Data were collected on the diagnosis of osteoporosis andtype of treatment. Analysis was requested with CTX determination. As a gold standard, the medication possession rate(MPR) was used. Using the ROC curve methodology, the theoretical CTX cut‐off point was established. Sensitivity, spe‐cificity and positive predictive values were calculated to estimate therapeutic compliance.Results:100 patients were included, of which more than half were being treated with alendronate. According to theMPR, 70% were compliant. The mean CTX value was 0.193±0.146 ng/ml. It was lower in the compliant patients. A valueof 0.196 ng/ml was established as a cut‐off point to assess compliance. The joint assessment of the CTX together withthe Morinsky‐Green questionnaire showed greater discriminatory capacity.Conclusions:Carrying out a single determination of CTX (<0.196 ng/ml) along with the Morinsky‐Green questionnaireallows us to more accurately assess the therapeutic compliance in patients treated with bisphosphonates


Assuntos
Humanos , Feminino , Idoso , Reabsorção Óssea/sangue , Difosfonatos/administração & dosagem , Difosfonatos/sangue , Osteoporose Pós-Menopausa/sangue , Osteoporose Pós-Menopausa/tratamento farmacológico , Cooperação e Adesão ao Tratamento , Biomarcadores/sangue , Inquéritos e Questionários
5.
Endodoncia (Madr.) ; 36(3): 32-42, dic. 2018. ilus
Artigo em Espanhol | IBECS | ID: ibc-178384

RESUMO

La evaluación radiográfica y las pruebas diagnósticas son de vital importancia para realizar un adecuado plan de tratamiento en endodoncia. En el campo de la endodoncia, tradicionalmente se han utilizado diferentes pruebas como la palpación, la percusión, las pruebas de sensibilidad pulpar y las radiografías periapicales (RP). Hasta la actualidad las RP (convencionales o digitales) han sido un complemento indispensable para realizar el tratamiento endodóntico, así como para determinar el éxito de dicho tratamiento. Sin embargo, está demostrado que las RP presentan ciertas limitaciones como superposiciones de estructuras anatómicas, la visión en dos dimensiones (2D) y la distorsión geométrica. Las imágenes obtenidas mediante RP ofrecen solamente datos de la dimensión mesio-distal, lo que dificulta la detección de cierta información como: la anatomía radicular, la presencia de alteraciones alrededor de las raíces, la pérdida ósea, los diferentes tipos de reabsorciones radiculares, las fracturas radiculares y otros aspectos importantes en la planificación de una cirugía apical. A través de la imágenes obtenidas a partir de la tomografía computarizada de haz cónico (TCHC), en inglés llamada cone-beam computed tomography (CBCT), se puede obtener una mayor información diagnóstica en comparación a las RP preoperatorias; información que influye directamente en el plan de tratamiento del clínico, especialmente en los casos de dificultad alta. Por todo a ello, en este artículo se presentan diferentes situaciones clínicas en las que la CBCT juega un papel fundamental en relación al plan de tratamiento endodóncico


No disponible


Assuntos
Humanos , Dente não Vital/diagnóstico por imagem , Dente não Vital/terapia , Tomografia Computadorizada de Feixe Cônico/métodos , Abscesso Periapical/diagnóstico por imagem , Reabsorção Óssea/diagnóstico por imagem , Reabsorção de Dente/diagnóstico por imagem , Traumatismos Dentários/diagnóstico por imagem , Doenças Periapicais/diagnóstico por imagem , Tecido Periapical/diagnóstico por imagem
6.
Rev. Soc. Andal. Traumatol. Ortop. (Ed. impr.) ; 35(3): 19-28, jul.-sept. 2018. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-175468

RESUMO

Objetivo: Evaluar la incidencia de complicaciones y la calidad de vida tras la cirugía en dos grupos de pacientes sometidos a artroplastia total de cadera no cementadas con vástagos corto y con vástagos estándar. Material y Métodos: Se realiza un estudio retrospectivo sobre un total de 106 artroplastias total de cadera implantadas en el Hospital Universitario de Puerto Real entre 2011 y 2015. Se comparan las siguientes variables: estancia hospitalaria, necesidad de transfusión sanguínea, complicaciones mecánicas, necesidad de revisión por cualquier causa, parámetros radiológicos (reabsorción del calcar, hundimiento, dismetría postquirúrgica, metría de cuello remanente) y dolor en cara anterior de muslo en dos grupos homogéneos de 63 vástagos convencionales anatómicos no cementados con 43 vástagos cortos de estabilización metafisaria y preservación parcial del cuello femoral ("partial collum"), implantadas por un mismo cirujano. Para el análisis estadístico se utilizó la T de Student para el análisis de variables cuantitativas y Chi cuadrado para variables cualitativas. Resultados: Los resultados muestran diferencias estadísticamente significativas (p< 0.05) en cuanto a variables estancia hospitalaria postquirúrgica, fracturas periprotésicas, dismetría, complicaciones mecánicas y metría del cuello remanente. Conclusiones: Los resultados avalan el empleo de vástagos cortos de estabilización metafisaria y preservación parcial del cuello femoral en pacientes jóvenes con adecuada calidad ósea y bien seleccionados, dadas las ventajas clínicas que suponen


Objetives: To evaluate the incidence of complications and the quality of life after surgery in two groups of patients undergoing total hip arthroplasty not cemented with a short stem and with a standard uncemented stem. Material and Methods: A retrospective study was performed in a total of 106 total hip arthroplasties implanted in the University Hospital of Puerto Real between 2011 and 2015. The following variables are compared: hospital stay, need for blood transfusion, mechanical complications, need for revision for any reason , radiological parameters (calcar resorption, subsidence, postsurgical dysmetria, remnant neck metrics) and anterior thigh pain in two homoge-nous groups of 63 conventional uncemented anatomical stems with 43 short stems of metaphyseal stabilization and partial femoral neck preservation ("Partial collum"), implanted by the same surgeon. For the statistical analysis, T Student was used for the analysis of quantitative variables and Chi-square for qualitative variables. Results: The results show statistically significant differences (p < 0.05) in terms of postsurgical hospital stay variables, periprosthetic fractures, dysmetria, mechanical complications and metrics of the remaining neck. Conclusions: The results support the use of short stems of metaphyseal stabilization and preservation of the greater trochanter in young patients with adequate bone quality given the clinical advantages they imply


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Qualidade de Vida , Reabsorção Óssea/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Artroplastia de Quadril/instrumentação , Prótese de Quadril/classificação , Estudos Retrospectivos , Tempo de Internação , Transfusão de Sangue , Reabsorção Óssea/cirurgia , Prótese de Quadril
7.
Med. oral patol. oral cir. bucal (Internet) ; 23(2): e216-e224, mar. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-171403

RESUMO

Background: Older alveolar cleft patients (>12 years old) often have wide bone defect as well as teeth loss, resulting in poor osseous healing with conventional alveolar bone grafting (ABG). In this study, we investigated a surgical technique of block iliac bone grafting for the alveolar cleft reconstruction and evaluated the clinical and radiological outcomes of these cleft patients. Material and Methods: Fifteen patients were included in this study. All cases received preoperative cone bean computed tomography (CBCT) scans for the alveolar cleft evaluation. Osseous outcomes of block iliac bone grafting were assessed at 1 week, 3- and 6-month postoperatively. Volume changes and bone resorption rates were calculated using the measurement modules of Simplant software. Bone samples from one patient undergoing dental implantation were assessed by micro-CT and histological examination. The morbidities of donor-site were analyzed by clinical examination and questionnaire survey. Results: The average age of the case series was 18.53±2.50 years. The intraoral incision of thirteen cases healed well. However, two cases had oronasal fistula and graft exposure at 1-week postoperatively. The results of follow-up CBCT scans showed significant resistance to radiation on both sides of the bone graft, suggesting a good osseous healing and new bone formation. The mean residual bone volume was 1.68±0.26 cm3 , 1.29±0.23 cm3 and 1.15±0.23 cm3 at 1-week, 3- and 6-month postoperatively. Correspondingly, the mean bone resorption rates in 3- and 6-month postoperative were 21.78±6.88% and 30.66±8.97%, respectively. From micro-CT and HE examinations, the block bone samples exhibited a cancellous structure in which mature bone trabecula and functional blood vessels appeared. The average scores of donor-site morbidities were drastically decreased at 3- and 6-month postoperatively compared with those at 1-week postoperatively. Conclusions: Our results demonstrated that block iliac bone grafting could achieve satisfying osseous outcomes in older alveolar cleft patients, and this technique provided favorable bony condition for further treatments, especially dental implantation (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Ílio/diagnóstico por imagem , Ílio/cirurgia , Reabsorção Óssea/diagnóstico por imagem , Reabsorção Óssea/cirurgia , Implantação Dentária/métodos , Perda de Dente/diagnóstico por imagem , Perda de Dente/cirurgia , Aparelhos Ativadores , Ortodontia/métodos , Ortodontia Corretiva
8.
J. physiol. biochem ; 74(1): 3-8, feb. 2018. graf
Artigo em Inglês | IBECS | ID: ibc-178912

RESUMO

The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. It was recently reported that deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass but the underlying cellular mechanism leading to this phenotype remains unclear. Here, we independently corroborate the increased thickness of cortical bone in femurs of 20-week-old male Tas1R3 mutant mice and confirm that Tas1R3 is expressed in the bone environment. Tas1R3 is expressed in undifferentiated bone marrow stromal cells (BMSCs) in vitro and its expression is maintained during BMP2-induced osteogenic differentiation. However, levels of the bone formation marker procollagen type I N-terminal propeptide (PINP) are unchanged in the serum of 20-week-old Tas1R3 mutant mice as compared to controls. In contrast, levels of the bone resorption marker collagen type I C-telopeptide are reduced greater than 60% in Tas1R3 mutant mice. Consistent with this, Tas1R3 and its putative signaling partner Tas1R2 are expressed in primary osteoclasts and their expression levels positively correlate with differentiation status. Collectively, these findings suggest that high bone mass in Tas1R3 mutant mice is due to uncoupled bone remodeling with reduced osteoclast function and provide rationale for future experiments examining the cell-type-dependent role for TAS1R family members in nutrient sensing in postnatal bone remodeling


No disponible


Assuntos
Animais , Masculino , Reabsorção Óssea/metabolismo , Osso Cortical/metabolismo , Regulação da Expressão Gênica no Desenvolvimento , Células-Tronco Mesenquimais/metabolismo , Osteoblastos , Osteoclastos/metabolismo , Osteogênese , Receptores Acoplados a Proteínas-G/metabolismo , Biomarcadores/metabolismo , Reabsorção Óssea/imunologia , Reabsorção Óssea/patologia , Catepsina K , Linhagem Celular , Osso Cortical , Células-Tronco Mesenquimais/citologia , Camundongos Endogâmicos C57BL , Camundongos Knockout , Camundongos Mutantes
9.
Reumatol. clín. (Barc.) ; 14(1): 20-26, ene.-feb. 2018. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-170368

RESUMO

Objetivo. Determinar en radiografía simple los hallazgos anormales del penacho de la falange distal de los dedos de la mano (PFDM) asociados a la esclerosis sistémica (ES) en adultos. Métodos. Se desarrolló una revisión sistemática siguiendo los parámetros de las guías PRISMA en las bases de datos: MEDLINE, EMBASE, BIREME, Scielo, Google Scholar entre otras incluyendo como resultados primarios las alteraciones del PFDM (erosiones, resorción, esclerosis y proliferación) detectadas por radiografía simple en sujetos con ES. La prevalencia de los hallazgos radiográficos fue sintetizada usando el modelo de efectos fijos. Las asociaciones estadísticas (según el tipo de estudio) se expresaron en términos de riesgo relativo u odds ratio con sus respectivos intervalos de confianza y valores p. Resultados. Veintidós estudios observacionales fueron incluidos, la prevalencia de resorción del PFDM fue de 28,3% (IC 95%: 0,256-0,312; p<0,001) y un valor I2=80,4%, la prevalencia de calcinosis fue de 15,6% (IC 95%: 0,113-0,210; p<0,001) y un valor I2=0%. Ningún estudio reportó proliferación o erosiones y solo un estudio describió esclerosis del PFDM en 5 pacientes. Conclusiones. La resorción y calcinosis del PFDM son los hallazgos radiográficos característicos en pacientes con ES, sin embargo hacen falta estudios con una mayor solidez metodológica que permitan establecer con certeza las asociaciones entre estos fenómenos y la presencia de otras enfermedades del tejido conectivo (AU)


Objective. To determine abnormal plain radiograph findings of the distal phalanx tuft of the hand (DPTH) associated with systemic sclerosis in adults. Methods. A systematic review was developed following the parameters of the PRISMA guidelines in databases: MEDLINE, EMBASE, BIREME, Scielo, Google Scholar and others including as primary outcomes alterations of DPTH (erosions, resorption, sclerosis and proliferation) detected by simple radiography in subjects with systemic sclerosis. The prevalence of radiographic findings was synthesized using the fixed effects model. The statistical associations were expressed in terms of relative risk or odds ratio with their respective confidence intervals and p values. Results. Twenty-two observational studies were included; the prevalence of DPTH resorption was 28.3% (95% CI: 0.256-0.312; p < .001); I2=80.4%, the prevalence of calcinosis was 15.6% (95% CI: 0.113-0.210; p < .001); I2=0%. No study reported proliferation or erosions and only one study described sclerosis of DPTH in 5 individuals. Conclusions. Resorption and calcinosis of DPTH are the characteristic radiographic findings in patients with systemic sclerosis. However, new studies with greater methodological strength are needed to establish associations between these phenomena and their presence in other connective tissue diseases (AU)


Assuntos
Humanos , Escleroderma Sistêmico/diagnóstico por imagem , Falanges dos Dedos da Mão/diagnóstico por imagem , Mãos/diagnóstico por imagem , Reabsorção Óssea/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Acro-Osteólise/diagnóstico por imagem
10.
Med. oral patol. oral cir. bucal (Internet) ; 22(4): e512-e519, jul. 2017. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-164954

RESUMO

Background: The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology. Material and Methods: An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles dated from January 2000 to December 2016. Two reviewers assessed the quality of the studies independently. Results: A total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis. Comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, all of them animal research papers that showed heterogeneity in the methodologies used and a high or moderate risk of bias. Conclusions: The topical application of bisphosphonate solution would appear to favor new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density (AU)


No disponible


Assuntos
Humanos , Difosfonatos/farmacocinética , Reabsorção Óssea/tratamento farmacológico , Osteogênese , Implantação Dentária/métodos , Administração Tópica , Regeneração Óssea , Materiais Biocompatíveis/uso terapêutico
11.
Med. clín (Ed. impr.) ; 149(2): 78-82, jul. 2017. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-164732

RESUMO

Las personas con síndrome de Down podrían tener un mayor riesgo de osteoporosis debido a un envejecimiento precoz, alteraciones en el desarrollo o la presencia de factores de riesgo como baja actividad física, menor exposición solar, elevada comorbilidad o el uso de tratamientos que afectan al metabolismo óseo. Además, tienen peculiaridades antropométricas y de composición corporal que podrían influir en su masa ósea. Los estudios en adultos vienen a decir que tienen una densidad mineral ósea en g/cm2 inferior a la de la población general, pero la mayoría no tienen en cuenta el menor tamaño de sus huesos, de tal manera que cuando se ajusta por el mismo (densidad mineral ósea volumétrica g/cm3), estas diferencias se reducen o desaparecen. Los estudios sobre niveles de 25(OH)D, parámetros de remodelación ósea o prevalencia de fracturas no son concluyentes (AU)


Patients with Down syndrome have a number of risk factors that theoretically could predispose them to osteoporosis, such as early aging, development disorders, reduced physical activity, limited sun exposure, frequent comorbidities and use of drug therapies which could affect bone metabolism. In addition, the bone mass of these people may be affected by their anthropometric and body composition peculiarities. In general terms, studies in adults with Down syndrome reported that these people have lower areal bone mineral density (g/cm2) than the general population. However, most of them have not taken the smaller bone size of people with Down syndrome into account. In fact, when body mineral density is adjusted by bone size and we obtain volumetric body mineral density (g/cm3), the difference between both populations disappears. On the other hand, although people with Down syndrome have risk factor of hypovitaminosis D, the results of studies regarding 25(OH)D in this population are not clear. Likewise, the studies about biochemical bone markers or the prevalence of fractures are not conclusive (AU)


Assuntos
Humanos , Síndrome de Down/complicações , Osteoporose/epidemiologia , Reabsorção Óssea/fisiopatologia , Envelhecimento/fisiologia , Fatores de Risco , Densidade Óssea/fisiologia , Deficiência de Vitamina D/epidemiologia , Comportamento Sedentário , Pesos e Medidas Corporais
13.
Nefrología (Madr.) ; 36(4): 368-375, jul.-ago. 2016. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-155394

RESUMO

Una de las principales causas de morbimortalidad en el paciente con enfermedad renal crónica es la cardiovascular. La inflamación y las alteraciones en el metabolismo óseo mineral son una condición patológica que conlleva aumento del riesgo cardiovascular en la enfermedad renal crónica. Los parámetros bioquímicos clásicos del metabolismo óseo mineral como fósforo, calcio, vitamina D y PTH tienen una implicación muy conocida en el riesgo cardiovascular. Los nuevos marcadores, FGF23 y klotho, también podrían estar implicados en la enfermedad cardiovascular (AU)


Cardiovascular factors are one of the main causes of morbidity and mortality in patients with chronic kidney disease. Bone mineral metabolism disorders and inflammation are pathological conditions that involve increased cardiovascular risk in chronic kidney disease. The cardiovascular risk involvement of bone mineral metabolism classical biochemical parameters such as phosphorus, calcium, vitamin D and PTH is well known. The newest markers, FGF23 and klotho, could also be implicated in cardiovascular disease (AU)


Assuntos
Humanos , Insuficiência Renal Crônica/fisiopatologia , Reabsorção Óssea/etiologia , Doenças Cardiovasculares/epidemiologia , Densidade Óssea/fisiologia , Fatores de Risco , Inflamação/fisiopatologia
14.
Aten. prim. (Barc., Ed. impr.) ; 48(5): 316-324, mayo 2016. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-151918

RESUMO

OBJETIVO: Evaluar la persistencia del tratamiento con risedronato mensual y conocer los motivos de persistencia y no persistencia terapéutica y el perfil de las pacientes no persistentes. DISEÑO: Estudio observacional, postautorización y prospectivo. Emplazamiento: Consultas de atención primaria, traumatología, reumatología, ginecología y geriatría de Cataluña. PARTICIPANTES: Mujeres con osteoporosis en tratamiento con risedronato mensual que previamente hubiesen abandonado el tratamiento con bifosfonato semanal. MEDICIONES PRINCIPALES: Porcentaje de pacientes bajo risedronato mensual persistentes al año de su prescripción, motivos de persistencia y no persistencia y perfil de pacientes no persistentes en relación a datos biodemográficos, datos clínicos y factores de riesgo de fractura. RESULTADOS: Doscientos ochenta y nueve pacientes valorables con una edad media de 68,3. A los 12 meses de inicio de risedronato mensual, un 58,1% de las pacientes persistía con el tratamiento. Motivos más frecuentes de abandono: miedo a tener efectos secundarios y creencia de que la enfermedad es propia de la edad. Motivos de persistencia destacables: comodidad/facilidad y posología. Se observaron diferencias significativas entre pacientes persistentes y no persistentes en relación a: situación laboral, número de tratamientos concomitantes y talla; sin embargo los resultados de posibles factores asociados deben contextualizarse dentro de las características del estudio y la diferencia de talla no parece clínicamente relevante. CONCLUSIONES: La administración de pautas terapéuticas más cómodas, como risedronato mensual en la osteoporosis, podría facilitar la persistencia en los pacientes mejorando la efectividad del fármaco. Sin embargo, en dicha persistencia pueden influir también variables biodemográficas y clínicas de diversa índole


OBJECTIVE: To assess the persistence of treatment with monthly risedronate and know the reasons of persistence and nontherapeutic persistence and the profile of the non-persistent patients. Desing: Observational, postmarketin and prospective study. LOCATION: Primary care, traumatology, rheumatology, gynecology and geriatrics of Catalonia. PARTICIPANTS: Women with osteoporosis treated with monthly risedronate that previously had abandoned weekly bisphosphonate therapy. MAIN MEASUREMENTS: Percentage of patients on persistent monthly risedronate year of their prescription, reasons for persistent and non persistent and profile of non persistent patients in relation to biodemographic data, clinical data and risk factors for fracture. RESULTS: 289 evaluable patients with a mean age of 68.3. At 12 months of initiation with monthly risedronate, 58.1% of patients remained on treatment. Most frequent reasons for leaving: fear of having side effects and belief that the disease is typical of the age. Reasons remarkable persistence: comfort/ease and dosage. Significant differences were observed between persistent and non-persistent patients relative to: employment status, number of concomitant therapy and height; however the results of possible associated factors must be contextualized within the study characteristics and the difference in size does not seem clinically relevant. CONCLUSIONS: The administration of therapeutic patterns more comfortable as monthly risedronate in osteoporosis, could facilitate persistence in patients improving the effectiveness of the drug. However in that persistence can also influence biodemographic and clinical variables and diverse of various kinds


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Osteoporose/diagnóstico , Osteoporose/prevenção & controle , Osteoporose/terapia , Ácido Risedrônico/análise , Ácido Risedrônico/farmacologia , Ácido Risedrônico/uso terapêutico , Reabsorção Óssea/diagnóstico , Reabsorção Óssea/prevenção & controle , Fatores de Risco , Mulheres , Atenção Primária à Saúde , Fraturas Ósseas , Densidade Óssea/fisiologia , Difosfonatos/farmacologia , Difosfonatos/uso terapêutico , Alendronato/farmacologia , Alendronato/uso terapêutico , Resultado do Tratamento , Estudo Observacional , Estudos Prospectivos , Espanha
15.
Cient. dent. (Ed. impr.) ; 13(1): 57-62, ene.-abr. 2016. ilus
Artigo em Espanhol | IBECS | ID: ibc-152745

RESUMO

Tras una extracción dental se produce un proceso fisiológico de reabsorción ósea, que origina una pérdida de volumen en los maxilares, y que de producirse a nivel de la tabla ósea vestibular se conoce con el término de colapso vestibular. Para evitar o reducir el nivel de reabsorción se llevan a cabo técnicas de preservación alveolar. En determinadas situaciones la pérdida de volumen es previa a la exodoncia, y va acompañada de pérdida de inserción de tejidos blandos. En estos casos se pueden utilizar membranas sintéticas no reabsorbibles de politetrafluoroetileno (PTFE), que aíslan el alveolo del epitelio y el medio externo. Se presenta el caso de un varón de 48 años que muestra una recesión gingival severa con fenestración apical en el diente 11. Tras la extracción se rellena el alveolo con aloinjerto desmineralizado Mineross y membrana de PTFE. A los 5 meses, y con la mejoría de volumen óseo obtenido se procede a la colocación de un implante en la posición tridimensional ideal en el maxilar, y de un injerto de tejido conectivo subepitelial para optimizar el volumen de tejido blando (AU)


After a tooth extraction a physiological process of bone resorption occurs, resulting in a loss of volume in the maxillary, and because it occurs at the level of the buccal bone plate is known by the term vestibular collapse. To avoid or reduce the level of absorption, techniques of alveolar preservation are carried out. In certain situations the volume loss is prior to extraction, and it is accompanied by insertion loss of soft tissue. In these cases you can use non absorbable synthetic polytetrafluoroethylene (PTFE) membranes, which isolate the socket of the epithelium and the external environment. For a 48 year old male showing severe gingival recession with apical fenestration on tooth 11. After dental extraction the socket is filled with demineralized allograft Mineross and PTFE membrane. 5 months later, and with improvement of bone volume obtained, following process is the placement of an implant in an ideal three-dimensional position in the maxillary, and a subepithelial connective tissue graft to optimize the volume of soft tissue (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Extração Dentária/efeitos adversos , Reabsorção Óssea/fisiopatologia , Vestibuloplastia/métodos , Tecido Conjuntivo/transplante , Regeneração Tecidual Guiada/métodos , Retalhos Cirúrgicos
16.
Med. oral patol. oral cir. bucal (Internet) ; 20(6): e651-e656, nov. 2015. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-144695

RESUMO

Background: The aim of this study was to evaluate the effects of long and short term systemic usage of royal jelly on bone formation in the expanded maxillary suture in a rat model. Material and Methods: Twenty eight Wistar albino rats were randomly divided into 4 equal groups: Control (C); Only Expansion (OE), Royal Jelly (RJ) group, Royal Jelly was given to rats by oral gavage only during the expansion and retention period; Royal Jelly plus Nursery (RJN) group, Royal Jelly was given to rats by oral gavage during their nursery phase of 40 days and during the retention period. After the 5 day expansion period was completed, the rats underwent 12 days of mechanical retention. All rats were sacrificed in same time. Histological examination was performed to determine the number of osteoclasts, number of osteoblasts, number of capillaries, inflammatory cell infiltration, and new bone formation. Results: New bone formation, number of osteoclasts, number of osteoblasts, and the number of capillaries in the expanded maxillary sutures were higher in the RJ and RJN groups than in the other groups. Statistical analysis also demonstrated that new bone formation and the number of osteoblasts was also highest in the RJN group. Conclusions: The systemic administration of Royal Jelly in conjunction with rapid maxillary expansion may increase the quality of regenerated bone (AU)


Assuntos
Animais , Feminino , Masculino , Ratos , Maxila/patologia , Maxila , Osteogênese/fisiologia , Modelos Animais , Mel , Oclusão Dentária , Osteoclastos/fisiologia , Reabsorção Óssea , Fenômenos Fisiológicos Dentários
17.
Rev. Esp. Cir. Ortop. Traumatol. (Ed. Impr.) ; 59(5): 365-371, sept.-oct. 2015. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-140879

RESUMO

No hay consenso en el tratamiento de elección de los recambios protésicos de rodilla con defectos óseos severos. Las opciones son variadas, cada una con sus ventajas e inconvenientes. Los trabajos clínicos publicados tienen sus limitaciones en cuanto al número de pacientes y el poco seguimiento clínico. Se presenta un trabajo biomecánico con elementos finitos comparativo de 5 diseños de implantes tibiales: vástago recto, con offset con/sin suplemento y vainas con/sin vástago, para poder analizar el comportamiento tanto del hueso tibial como del material a lo largo del tiempo. Dentro de las limitaciones que presenta un modelo matemático hemos podido ver que los implantes con vástago recto producen el mayor valor de reabsorción ósea alrededor del vástago, mientras que la menor reabsorción ósea tiene lugar en el hueso de la diáfisis proximal. Las vainas metafisarias tibiales sin vástago producen una menor reabsorción ósea que el resto en el canal medular (AU)


The best management of severe bone defects following total knee replacement is still controversial. Metal augments, tantalum cones and porous tibial sleeves could help the surgeon to manage any type of bone loss, providing a stable and durable knee joint reconstruction. Five different types of prostheses have been analysed: one prosthesis with straight stem; two prostheses with offset stem, with and without supplement, and two prostheses with sleeves, with and without stem. The purpose of this study is to report a finite element study of revision knee tibial implants. The main objective was to analyse the tibial bone density changes and Von Misses tension changes following different tibial implant designs. In all cases, the bone density decreases in the proximal epiphysis and medullary channels, with a bone density increase also being predicted in the diaphysis and at the bone around the stems tips. The highest value of Von Misses stress has been obtained for the straight tibial stem, and the lowest for the stemless metaphyseal sleeves prosthesis (AU)


Assuntos
Feminino , Humanos , Masculino , Artroplastia do Joelho/instrumentação , Artroplastia do Joelho/métodos , Artroplastia do Joelho , Tíbia/fisiologia , Remodelação Óssea , Remodelação Óssea/imunologia , Remodelação Óssea/fisiologia , Próteses e Implantes , Reabsorção Óssea/diagnóstico , Reabsorção Óssea/fisiopatologia , Diáfises/fisiologia , Tomografia Computadorizada de Emissão/métodos , Osso e Ossos/fisiologia , Osso e Ossos , Densidade Óssea/fisiologia
18.
Av. periodoncia implantol. oral ; 27(2): 75-78, ago. 2015. graf
Artigo em Espanhol | IBECS | ID: ibc-141506

RESUMO

La etiología de la enfermedad periodontal está bien definida, dentro de los agentes etiológicos que la causan podemos citar algunos microorganismos subgingivales como: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Actinobacillus actinomycetemcomitans y espiroquetas. La susceptibilidad del huésped a estos agentes bacterianos también tiene un papel importante dentro del progreso y prevalencia de la enfermedad periodontal. Dentro de los factores de riesgo asociados con la enfermedad periodontal tenemos: el aumento de edad, presencia de bio- film dental o placa bacteriana patogénica, alteración del estado inmunológico, deficiencia nutricional, el uso de medicamentos como corticoides, género, estrés, tabaco, factores genéticos y condiciones sistémicas, dentro de estas se incluyen alteraciones de neutrófilos, diabetes, embarazo, osteoporosis y hormonales. La enfermedad periodontal puede ser exacerbada por determinados factores sistémicos como la deficiencia o aumento de hormonas como estrógeno y progesterona. La presente revisión de literatura tiene por objeto dilucidar la influencia del estrógeno en la enfermedad periodontal (AU)


The etiology of periodontal disease is well defined within the etiologic agents that cause this disease. We can cite some subgingival microorganisms as gingivallis Porphyromonas, Prevotella intermedia, Bacteroides forsythus, Actinobacillus actinomycetemcomitans and spirochetes. The host susceptibility to these bacterial agents also has an important role in the progress and prevalence of periodontal disease. Among the risk factors associated with periodontal disease are: increasing age, presence of dental biofilm or pathogenic plaque, altered immune status, nutritional deficiency, use of medications such as corticosteroids, gender, stress, snuff, genetic factors and systemic conditions within these alterations are included neutrophils, diabetes, pregnancy, osteoporosis and hormones. Periodontal disease can be exacerbated by certain systemic factors such as deficiency or increased hormones like estrogen and progesterone. This literature review aims to elucidate the influence of estrogen in periodontal disease (AU)


Assuntos
Feminino , Humanos , Masculino , Doenças Periodontais/induzido quimicamente , Doenças Periodontais/complicações , Doenças Periodontais/diagnóstico , Estrogênios/efeitos adversos , Estrogênios/metabolismo , Reabsorção Óssea/induzido quimicamente , Reabsorção Óssea/complicações , Reabsorção Óssea/diagnóstico , Literatura de Revisão como Assunto , Doenças Periodontais/fisiopatologia , Doenças Periodontais/terapia , Reabsorção Óssea/fisiopatologia , Estrogênios/deficiência
19.
Med. oral patol. oral cir. bucal (Internet) ; 20(4): e480-e488, jul. 2015. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-138976

RESUMO

Background: To assess and compare survival rates of immediately and delayed loaded short implants (7 mm) in free ends of a partially edentulous jaw with moderate-severe alveolar bone resorption. Material and Methods: 24 patients with atrophic edentulous free-ends were included in this prospective study. Four study groups were monitored monthly and their behavior was evaluated: bridges supported only by short implants and mixed short and long implant bridge groups, both with immediate and delayed loading. Failures, bone loss, probing depth and bleeding on probing were evaluated. Results: 54 Mk III Shorty TiU and 15 Brånemark System®MK III TiU implants with a length longer than 7mm were included in the study. Twenty-eight implants were inserted following the immediate loading protocol and 26 according a two-stage procedure, depending on the torque value. The cumulative survival rate of short implants was 87% (n=54) after a mean time of 47.72 months (range 33-62 months), showing statistically significant differences related to loading protocol (p=0.047). Short implants immediately loaded had a higher long-term survival rate (96.4%) compared to the other study group (76.9%). Besides, short implants splinted to longer immediately loaded implants presented the highest survival rate (100%). Twenty-five (53.19%) short implants showed a bone loss of less than one millimeter after the follow-up period. Statistically significant differences were found between bleeding on probing, presence of plaque or suppuration and a higher bone loss in both loading protocols (p= 0.0 01). Conclusions: Immediate loading of short implants placed on free ends can be considered an option in the treatment protocol of patients with severe bone resorption especially if implants are splinted to others of greater length (AU)


No disponible


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Implantes Dentários/normas , Implantes Dentários/tendências , Implantes Dentários , Carga Imediata em Implante Dentário/métodos , Carga Imediata em Implante Dentário/tendências , Estudos Prospectivos , Reabsorção Óssea/epidemiologia , Reabsorção Óssea/fisiopatologia , Carga Imediata em Implante Dentário/normas , Carga Imediata em Implante Dentário
20.
Clin. transl. oncol. (Print) ; 17(6): 454-461, jun. 2015. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-138714

RESUMO

Background: A negative side effect of therapeutic irradiation is the radiation-induced bone loss which can lead, in long term, to pathological fractures. Until today, the detailed mechanism is unknown. If osteoclasts would mainly contribute to the pathological bone loss, bisphosphonates could potentially counteract the osteolytic process and possibly help to prevent long-term complications. The aim of this study was to evaluate the effect of zoledronic acid on the early radiation-induced degradation of bone collagen fibrils by monitoring the urinary excretion of hydroxylysylpyridinoline and lysylpyridinoline under radiotherapy. Patients and methods: A total of 40 patients with skeletal metastases were assigned for a local radiotherapy and bisphosphonate treatment. The patients were prospectively randomized into two treatment groups: group A (n = 20) received the first zoledronate administration after and group B (n = 20) prior to the radiotherapy. Urine samples were collected from each patient on the first day, in the middle, and on the last day of the radiation therapy. Measurement of the bone metabolites hydroxylysylpyridinoline and lysylpyridinoline was performed by high-performance liquid chromatography. Statistical analysis was performed using the Mann–Whitney U test. Results: The hydroxylysylpyridinoline and lysylpyridinoline excretion decreased significantly in the combined bisphosphonate and radiotherapy group (p = 0.02, p = 0.08). No significant change of the hydroxylysylpyridinoline and lysylpyridinoline excretion was determined in the patients that received solely irradiation. Conclusion The results indicate the ability of zoledronate to prevent the early radiation-induced bone collagen degradation suggesting that the radiation-induced bone loss is mainly caused by osteoclastic bone resorption rather than by a direct radiation-induced damage (AU)


No disponible


Assuntos
Humanos , Difosfonatos/farmacocinética , Osteoporose/prevenção & controle , Reabsorção Óssea/prevenção & controle , Substâncias Protetoras/farmacocinética , Distúrbios do Metabolismo do Cálcio/prevenção & controle , Colágeno/efeitos da radiação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA