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1.
Cient. dent. (Ed. impr.) ; 16(3): 197-200, sept.-dic. 2019.
Artigo em Espanhol | IBECS | ID: ibc-185994

RESUMO

Las proteínas participan en el resguardo del estado fisiológico de los tejidos buco-dentales, contribuyendo en la protección y recuperación de los mismos. En el caso de la leptileptina, una citoquina tipo I reconocida por regular la ingesta de alimentos y el gasto energético, la evidencia actual señala además su rol en la inmunidad e inflamación, induciendo la producción de otras citoquinas y estimular la fagocitosis. Siendo la enfermedad periodontal la segunda patología bucodental más prevalente en el mundo, caracterizada por inflamación crónica, inducida por bacterias periodontopatógenas, es necesario conocer los elementos biológicos que participan en la patogenia de la misma. La siguiente revisión bibliográfica tiene como propósito discernir la participación de la leptina en la enfermedad periodontal. En el periodonto la leptina participa exhibiendo un comportamiento protector, donde la disminución de los niveles del péptido en encía, fluido crevicular gingival (FCG) y saliva, es inversamente proporcional al grado de severidad de la enfermedad periodontal; permitiendo considerar que la valoración de leptina en FCG puede ser empleada como herramienta de diagnóstico y pronóstico de las alteraciones periodontales


Proteins participate in the protection of the physiological state of the oral tissues, contributing in the protection and recovery of them. In the case of leptin, a type I cytokine, recognized for regulating food intake and energy expenditure, current evidence also points to its role in immunity and inflammation, inducing the production of other cytokines and stimulating phagocytosis. Being the periodontal disease the second most prevalent oral pathology in the world, characterized by chronic inflammation, induced by periodontopathogenic bacteria, it is necessary to know the biological elements that participate in the pathogenesis of it. The purpose of the following literature review is to discern the participation of leptin in periodontal disease. In the periodontium leptin participates exhibiting a protective behavior, where the decrease in the levels of the peptide in the gingiva, gingival crevicular fluid (FCG) and saliva, is inversely proportional to the degree of severity of the periodontal disease; allowing to consider that the evaluation of leptin in FCG can be used as a tool for diagnosis and prognosis of periodontal alterations


Assuntos
Humanos , Doenças Periodontais/tratamento farmacológico , Leptina/uso terapêutico , Leptina/imunologia , Leptina/metabolismo , Gengivite/tratamento farmacológico , Líquido do Sulco Gengival/efeitos dos fármacos
2.
Med. oral patol. oral cir. bucal (Internet) ; 24(5): e659-e672, sept. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-185685

RESUMO

Background: Despite decades of research, our knowledge of several important aspects of periodontal pathogenesis remains incomplete. Epigenetics allows to perform dynamic analysis of different variations in gene expression, providing this great advantage to the static measurement provided by genetic markers. The aim of this systematic review is to analyze the possible relationships between different epigenetic mechanisms and periodontal diseases, and to assess their potential use as biomarkers of periodontitis. Material and Methods: A systematic search was conducted in six databases using MeSH and non-MeSH terms. The review fulfilled PRISMA criteria (Preferred Reporting Items for Systematic reviews and Meta-analysis). Results: 36 studies met the inclusion criteria. Due to the heterogeneity of the articles, it was not possible to conduct quantitative analysis. Regarding qualitative synthesis, however, it was found that epigenetic mechanisms may be used as biological markers of periodontal disease, as their dynamism and molecular stability makes them a valu-able diagnostic tool. Conclusions: Epigenetic markers alter gene expression, producing either silencing or over-expression of molecular transcription that respond to the demands of the cellular surroundings. Gingival crevicular fluid collection is a non-invasive and simple procedure, which makes it an ideal diagnostic medium for detection of both oral and systemic issues. Although further research is needed, this seems to be a promising field of research in the years to come


No disponible


Assuntos
Humanos , Doenças Periodontais , Periodontite , Epigênese Genética , Líquido do Sulco Gengival , Periodontia
3.
Cient. dent. (Ed. impr.) ; 15(3): 173-178, sept.-dic. 2018. ilus
Artigo em Espanhol | IBECS | ID: ibc-182249

RESUMO

Desde hace bastantes años, se ha asociado regularmente el abuso del cannabis, y sobre todo en su forma más habitual, la marihuana, con una boca más descuidada. Los adictos al cannabis suelen tener mayores índices de placa, xerostomía y caries. Sin embargo, son pocas las publicaciones que relacionan la marihuana con enfermedad periodontal, salvo casos clínicos aislados. En este artículo, se revisa la literatura que existe al respecto y se presentan tres casos clínicos de pacientes fumadores habituales de marihuana con periodontitis


The abuse of cannabis, overall in its most habitual format, marihuana, has commonly been related to oral neglect. Cannabis abusers have higher plaque scores, xerostomia and increase in the risk of dental caries. Nevertheless, there are few the papers that show a relationship between marihuana and periodontal disease, except in isolated clinical cases. In this article, literatura related to the topic is revised and three cases report of habitual smokers of marihuana with necrotizing periodontitis are shown


Assuntos
Humanos , Masculino , Adulto , Doenças Periodontais/induzido quimicamente , Doenças Periodontais/diagnóstico , Cannabis/efeitos adversos , Periodontite/complicações , Periodontite/etiologia , Gengivite Ulcerativa Necrosante/complicações , Gengivite Ulcerativa Necrosante/etiologia , Abuso de Maconha/complicações
4.
Cient. dent. (Ed. impr.) ; 15(3): 217-224, sept.-dic. 2018. tab
Artigo em Espanhol | IBECS | ID: ibc-182256

RESUMO

El objetivo de este trabajo es revisar la literatura científica disponible sobre las consideraciones odontológicas y las manifestaciones orales que pueden presentar los pacientes asmáticos. Se han revisado 34 artículos publicados entre los años 2001 y 2018. En función de su fisiopatología hay 5 tipos de asma, y clínicamente se clasifica en leve, moderada y grave. Entre los factores de riesgo destacan el tabaco, obesidad, genética, factores socioeconómicos y exposición a ciertas sustancias. El tratamiento de elección se basa en los broncodilatadores y glucocorticoides inhalados. Esta medicación disminuye la cantidad de flujo y el pH salival. Por este motivo la cavidad oral es más susceptible de desarrollar patologías como caries, enfermedad periodontal y candidiasis oral. Concluimos que, dada la alta prevalencia del asma, es necesario que el odontólogo tenga en cuenta las consideraciones pre, intra y postoperatorias propuestas para los pacientes asmáticos, y evite los fármacos que puedan precipitar un ataque. El dentista debe estar familiarizado con esta enfermedad, y promover la salud oral en estos pacientes


The purpose of this work is to review the available scientific literature on the dental considerations and the oral manifestations that may present asthmatic patients. 34 articles published between 2001 and 2018 were reviewed. According to its pathophysiology, there are 5 types of asthma, and clinically, the asthma severity classification is divided into mild, moderate and severe. The principal risk factors for asthma include tobacco, obesity, genetics, socioeconomic factors and exposure to substances. The treatment of choice is based on inhaled bronchodilators and glucocorticoids. This medication decreases the amount of flow and salivary pH. For this reason, the oral cavity is more susceptible to developing pathologies such as caries, periodontal disease and oral candidiasis. Conclusions. Given the high prevalence of asthma, the dentist must carry out the dental treatment following the considerations proposed for patients with asthma and should know the pharmacological contraindications in these patients. The dentist should be familiar with this illness and promote the oral health in these patients


Assuntos
Humanos , Asma/tratamento farmacológico , Asma/epidemiologia , Fatores de Risco , Cárie Dentária/complicações , Cárie Dentária/epidemiologia , Doenças Periodontais/epidemiologia , Candidíase/epidemiologia , Asma/fisiopatologia , Espirometria/métodos , Diagnóstico Diferencial
5.
Ars pharm ; 59(4): 201-206, oct.-dic. 2018. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-177735

RESUMO

Introducción: La Calendula officinalis L. es una de las especies vegetales más utilizadas en el tratamiento de enfermedades periodontales. Objetivo: Determinar preliminarmente los parámetros de calidad de la jalea de Calendula officinalis L. al 1% para uso estomatológico. Métodos: Se elaboraron 18 formulaciones utilizando como agente gelificante carboximetilcelulosa (CMC) e hidroxipropilmetilcelulosa (HPMC), empleando el método de incorporación. A las mismas se le determinaron los parámetros de calidad y se seleccionaron las cuatro con mejores parámetros tecnológicos para evaluar el grado de aceptación sensorial por parte de un comité de expertos. Resultados: Las formulaciones con HPMC fueron las que presentaron mejores características organolépticas y pH aceptable para su aplicación sobre la mucosa bucal; así como un área de extensibilidad óptimo, lo que permitió que fueran seleccionadas para realizar el análisis sensorial. Conclusión: Se establecieron preliminarmente los parámetros de calidad de la jalea Calendula officinalis L. al 1% siendo seleccionada la formulación codificada como HPMC 6 por presentar olor característico al extracto blando, color ámbar tenue, homogéneo y con brillo, sabor agradable, no presentar grumos ni arenosidad, área de extensibilidad de 66.96±0.91cm2, pH de 4.9 y mayor aceptabilidad sensorial


Introduction: Calendula officinalis L. is one of the plant species most used in the treatment of periodontal diseases. Objective: To determine preliminarily the quality parameters of Calendula officinalis L. jelly at 1% for stomatological use. Methods: 18 formulations were prepared using carboxymethylcellulose (CMC) and hydroxypropylmethylcellulose (HPMC) as the gelling agent, using the incorporation method. The quality parameters were determined selecting the four formulations with better technological parameters to evaluate sensory acceptance by a committee of experts. Results: The HPMC formulations presented better organoleptic characteristics and acceptable pH for its application on the buccal mucosa; as well as an area of optimal extensibility, which allowed them to be selected to carry out the sensory analysis. Conclusion: The quality parameters of the Calendula officinalis L. 1% jelly were preliminarily established the formulation encoded as HPMC 6 is selected for presenting characteristic odor to the soft extract, amber color subdued, homogeneous and glossy, pleasant taste, no lumps or grit, area of extensibility of 66.96 ± 0.91cm2, pH of 4.9 and greater sensory acceptability


Assuntos
Humanos , Calendula , Doenças Periodontais/terapia , Geleificantes , Composição de Medicamentos/normas , Formulação e Envasilhamento de Substâncias, Produtos e Materiais
6.
Ars pharm ; 59(4): 235-250, oct.-dic. 2018. tab
Artigo em Espanhol | IBECS | ID: ibc-177739

RESUMO

Objetivos: La enfermedad periodontal es una de las enfermedades orales crónicas más comunes en todo el mundo y representa un importante problema de salud pública en muchos países. Las enfermedades periodontales incluyen periodontitis crónica y periodontitis agresiva que generalmente se debe a la inflamación de la encía causada por infecciones bacterianas. La nutrición podría ejercer un papel fundamental ya que participa en diferentes afecciones y enfermedades inflamatorias. Hasta ahora, solo algunos investigadores han investigado el papel de los nutrientes en el desarrollo y la progresión de la enfermedad periodontal, pero los resultados obtenidos a menudo son difíciles de comparar debido a la heterogeneidad de los estudios. Métodos: Este documento revisa sistemáticamente la literatura disponible en bases de datos hasta Febrero de 2018 sobre la relación entre macronutrientes y el desarrollo y progresión de enfermedades periodontales (periodontitis y gingivitis) en animales, con particular atención a los posibles mecanismos implicados en estas patologías. Resultados: Se encontraron un total de 5.484 publicaciones en la base de datos Pubmed. El análisis del título y resumen permitió seleccionar 88 artículos potenciales de acuerdo con los criterios de selección. No se encontraron artículos duplicados. La selección y lectura del texto complejo condujo a una cantidad final de 32 artículos. Conclusiones: Entre todos los macronutrientes analizados, aquellos que tienen algún efecto sobre el estrés oxidativo o el sistema inmune parecen ser importantes para la prevención de la enfermedad periodontal o la mejoría de la enfermedad periodontal. Por un lado, hay evidencia a favor de un papel positivo de la proporción de ácidos grasos n-3 en la dieta debido a sus efectos antioxidantes e inmunomoduladores. Por otro lado, las dietas ricas en grasas saturadas o hipercalóricas aumentan el estrés oxidativo o promueven la inflamación, por lo que deben evitarse


Objectives: Periodontal disease is one of the most common chronic oral diseases worldwide and represents a major public health problem in many countries. Periodontal diseases include chronic periodontitis and aggressive periodontitis that are usually due to the inflammation of gingiva caused by bacterial infections. Nutrition could exert a pivotal role due to its involvement in a number of inflammatory condition and diseases. Up to now, only some researchers have investigated the role of nutrients on the development and progression of periodontal disease, but the results obtained are often difficult to compare because of the heterogeneity of the studies. Methods: This paper systemically reviews the literature available on databases up to February 2018 on the relationship between macronutrients and the development and progression of periodontal diseases (periodontitis and gingivitis) in animals, with particular attention to the possible mechanisms involved in these pathologies. Results: A total of 5,484 publications were found in the Pubmed database. Title and abstract screening left 88 potential articles according to the selection criteria. No duplicated articles were found. Full-text screening and reading led to a final number of 32 articles. Conclusions: Among all the analyzed macronutrients, those that have any effect on oxidative stress or immune system seem to be important for the prevention of periodontal disease or periodontal disease improvement. On the one hand, there is evidence in favor of a positive role of n-3 fatty acid proportion in diet due to its antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich or hypercaloric diets increase oxidative stress or promote inflammation, so they must be avoided


Assuntos
Animais , Ratos , Nutrientes , Modelos Animais , Doenças Periodontais/terapia , Periodontite/terapia , Gengivite/terapia , Gengivite/veterinária , Saúde Pública , Infecções Bacterianas/terapia , Infecções Bacterianas/veterinária , Ratos Wistar
7.
Neurología (Barc., Ed. impr.) ; 33(9): 602-613, nov.-dic. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-176006

RESUMO

INTRODUCCIÓN: La enfermedad periodontal y la demencia son enfermedades muy prevalentes, especialmente en poblaciones envejecidas. Numerosos estudios han demostrado una relación entre ambas afecciones, pero la alta heterogeneidad en el diagnóstico, así como la metodología empleada, pueden dificultar la interpretación y la comparación de los resultados obtenidos. El objetivo de este artículo es realizar una revisión crítica de las publicaciones que asocian ambos procesos. DESARROLLO: Se incluyen 22 artículos, mayoritariamente estudios retrospectivos, y se analizan diversas variables metodológicas, como población de estudio, diagnóstico de periodontitis, definición de demencia, variables ajustadas y resultados. Además, se analizan los diferentes mecanismos etiopatogénicos que pueden influir en la progresión de ambas enfermedades y en la interacción entre ellas. CONCLUSIONES: Aunque la evidencia disponible indica una tendencia positiva a la asociación entre periodontitis y demencia, se desconoce el grado de esta asociación y la existencia de una relación causal entre ambas enfermedades


INTRODUCTION: Periodontal disease and dementia are very prevalent, especially in elderly populations. Multiple studies have shown a link between these diseases; however, the conditions are highly heterogeneous and so is the diagnostic methodology, which may hinder interpretation and comparison of the results. The aim of this article is to provide a critical review of the literature linking these 2 processes. DEVELOPMENT: We retrieved 22 studies, most of which were retrospective, and analysed various methodological variables including study population, diagnosis of periodontitis, definition of dementia, adjusted variables, and results. The different aetiopathogenic mechanisms that may affect the progression and interaction of these 2 conditions were also analysed. CONCLUSIONS: Although available evidence indicates a positive association between periodontitis and dementia, both the strength of that association and the presence of a causal relationship have yet to be determined


Assuntos
Humanos , Demência/epidemiologia , Doenças Periodontais/epidemiologia , Fatores de Risco , Periodontite/epidemiologia , Demência/psicologia , Doenças Periodontais/psicologia , Estudos Retrospectivos
8.
Med. oral patol. oral cir. bucal (Internet) ; 23(6): e681-e690, nov. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-176390

RESUMO

Background: Atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. Objective: To analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. Material and Methods: A systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. Results: Ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). Conclusions: Periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatment


No disponible


Assuntos
Humanos , Doenças Cardiovasculares/complicações , Doenças Periodontais/complicações , Doenças Periodontais/terapia
9.
Med. oral patol. oral cir. bucal (Internet) ; 23(5): e524-e530, sept. 2018. ilus
Artigo em Inglês | IBECS | ID: ibc-176369

RESUMO

Background: To review and discuss important topics regarding periodontal treatment pre- and post-radiotherapy for head and neck cancer in human patients; to discuss the references for adequate techniques, the appropriate moment for tooth extractions and periodontal management; and to discuss the prevention of osteoradionecrosis. Material and Methods: Thirty-nine studies including original studies, randomized clinical trials (RCTs) and reviews were searched in online databases MEDLINE (PubMed) and the Cochrane library. No year of publication restriction was applied. Results: Language was restricted to English, and the following Medical Subject Heading terms were used: radiotherapy, radiation therapy and periodontal treatment. Studies regarding periodontal treatment and tooth extraction that involved clinical management of irradiated patients were selected. Conclusions: The treatment of periodontal diseases before radiotherapy is mainly required to avoid future dental extraction and to reduce the development of osteoradionecrosis. Periodontal treatment in irradiated patients mostly includes scaling and root planing, extraction of condemned teeth and topical and systemic antimicrobial therapy. Tooth removal should be planned at least 14 days before the first day of radiation treatment. Particular care and mouthwashes should be taken during and after radiation. Clinical Significance: The management of irradiated patients represents a challenge for health professionals, including dentists. It is important to establish recommendations for clinicians concerning dental and periodontal management in irradiated patients before, during and after treatment


No disponible


Assuntos
Humanos , Neoplasias de Cabeça e Pescoço/radioterapia , Doses de Radiação , Osteorradionecrose/etiologia , Osteorradionecrose/prevenção & controle , Doenças Periodontais/etiologia , Doenças Periodontais/terapia
11.
Fontilles, Rev. leprol ; 31(4): 259-269, ene.-abr. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-173248

RESUMO

La lepra conlleva una serie de efectos secundarios indeseables que condicionan la tolerancia y la calidad de vida del paciente. Así, dentro de la esfera orofacial, la boca puede ser asiento de lesiones que, pese a su accesibilidad, pueden por ignorancia pasar desapercibidas y dificultar el adecuado tratamiento de un proceso que hasta ese momento había producido pocas lesiones corporales. Para ello, realizamos una revisión bibliográfica para estudiar el daño dental que esta grave enfermedad puede llegar a causar en la cavidad oral, comparando distintas poblaciones hansenianas


Leprosy involves a series of undesirable side effects, which determine the patient’s tolerance and quality of life. The mouth can be the seat of injuries, which despite their accessibility, can be unnoticed and impede the suitable treatment of a process, which up to that moment, had produced few skin injuries. We performed a bibliographic review to study the dental damage that this serious disease can cause in the oral cavity, comparing different Hansenian populations


Assuntos
Humanos , Hanseníase/epidemiologia , Doenças Periodontais/complicações , Boca/patologia , Cárie Dentária/diagnóstico , Índice CPO , Hanseníase/complicações , Doenças Dentárias/prevenção & controle
12.
Gac. sanit. (Barc., Ed. impr.) ; 32(2): 143-150, mar.-abr. 2018. graf, tab
Artigo em Inglês | IBECS | ID: ibc-171468

RESUMO

Objective: To assess the association between long sleep duration and periodontal disease among men and women using nationally representative data. Methods: In this study, we performed a cross-sectional analysis and used multivariable logistic regression analysis models. We analysed data from 2012 through 2014 from the Korean National Health and Nutrition Examination Survey. The analysis in this study was confined to a total of 14,675 respondents over 19 years of age. We used a community periodontal index code greater than or equal to 3 to define periodontitis. Results: The tendency of periodontitis increased with longer sleep duration in women. Compared with women who slept 5hours or less, women with a sleep duration of 6 to 8hours and 9hours or more had higher odds of periodontitis at 1.29 (95% confidence interval [95%CI]: 1.06-1.56) and 1.45 (95%CI: 1.07-1.96), respectively, after adjustment for age, smoking, drinking, exercise, frequency of tooth brushing, self-reported oral status, body mass index, diabetes mellitus, hypertension, white blood cell count, income, and education. A significant relationship between sleep duration and periodontitis was not found in men. Conclusion: Our findings suggest that long sleep duration was associated with periodontitis, after adjusting for potential confounding factors, among Korean women, especially in premenopausal women (AU)


Objetivo: Evaluar la asociación entre la larga duración del sueño y la enfermedad periodontal en hombres y mujeres utilizando datos nacionales representativos. Método: Se realizó un análisis transversal y se utilizaron modelos de análisis de regresión logística multivariable. Se analizaron los datos de 2012 a 2014 de la Encuesta Nacional de Salud y Nutrición de Corea. El análisis se limitó a 14.675 encuestados mayores de 19 años. Se utilizó un índice periodontal comunitario ≥3 para definir la periodontitis. Resultados: La tendencia a la periodontitis aumentó con una mayor duración del sueño en las mujeres adultas. En comparación con las mujeres que dormían 5 horas o menos, aquellas con una duración del sueño de 6 a 8 horas y 9 horas o más tenían probabilidades más altas de periodontitis: 1,29 (intervalo de confianza del 95% [IC95%]: 1,06-1,56) y 1,45 (IC95%: 1,07-1,96), respectivamente, después de ajustar por edad, hábito de fumar, consumo de alcohol, ejercicio, frecuencia de cepillado de dientes, estado oral informado, índice de masa corporal, diabetes mellitus, hipertensión, recuento de glóbulos blancos, ingresos y educación. Conclusión: Nuestros hallazgos sugieren que la larga duración del sueño se asoció con periodontitis, después de ajustar por los posibles factores de confusión, en las mujeres coreanas adultas, en especial en las premenopáusicas (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Síndromes da Apneia do Sono/epidemiologia , Doenças Periodontais/epidemiologia , Saúde Bucal/estatística & dados numéricos , Antropometria/métodos , Inquéritos Epidemiológicos/métodos , Inquéritos Epidemiológicos/estatística & dados numéricos , Análise Estatística , Modelos Logísticos
13.
Cient. dent. (Ed. impr.) ; 14(3): 167-172, sept.-dic. 2017. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-170385

RESUMO

La periodontitis es una infección polimicrobiana caracterizada por un proceso inflamatorio destructivo que resulta en la pérdida de los tejidos que sostienen los dientes. uno de sus principales agentes etiológicos, Porphyromonas gingivalis, es capaz de adherirse y formar un biofilm o placa, contribuyendo a la colonización de la cavidad bucal. También sintetiza proteasas que pueden degradar proteínas tisulares y plasmáticas, que contribuyen a la invasión de los tejidos periodontales. Los procedimientos habituales para evitar el progreso de la enfermedad periodontal no siempre consiguen el resultado clínico deseado. Sin embargo, varios estudios indican que los polifenoles del arándano, concretamente las proantocianidinas (PAC), pueden inhibir la formación de placa dental, la producción de ácido y de enzimas proteolíticas derivadas de distintos patógenos periodontales, así como la respuesta inflamatoria del huésped. La combinación de estos efectos puede contribuir al manejo de enfermedades como la caries, la gingivitis y la periodontitis (AU)


Periodontitis is a polymicrobial infection characterized by a destructive inflammatory process that results in the loss of teeth-supporting tissues. One of its main etiological agents, Porphyromonas gingivalis, is able to adhere and form a biofilm, contributing to the colonization of the oral cavity. It also synthesizes proteases that can degrade tissue and plasma proteins and contribute to the invasion of periodontal tissues. The usual procedures to prevent the progression of periodontal disease do not always achieve the expected clinical outcome. however, several studies indicate that cranberry polyphenols, namely proanthocyanidins (PACs), may inhibit the formation of dental plaque, the production of acid and proteolytic enzymes derived from different periodontal pathogens, as well as the host inflammatory response. The combination of these effects may contribute to the management of diseases such as caries, gingivitis and periodontitis (AU)


Assuntos
Humanos , Periodontite/prevenção & controle , Periodontite/terapia , Gengivite/prevenção & controle , Gengivite/terapia , Proantocianidinas/uso terapêutico , Vaccinium macrocarpon , Polifenóis/uso terapêutico , Doenças Periodontais/epidemiologia , Doenças Periodontais/prevenção & controle , Placa Dentária/tratamento farmacológico , Cárie Dentária/prevenção & controle
14.
Cient. dent. (Ed. impr.) ; 14(3): 213-219, sept.-dic. 2017. graf
Artigo em Espanhol | IBECS | ID: ibc-170392

RESUMO

El consumo de tabaco y, en concreto las formas de éste sin humo, son determinantes en el desarrollo de carcinoma en cavidad oral y fibrosis oral submucosa, entre otras entidades. El objetivo de este trabajo es hacer una revisión de la literatura sobre las diferentes formas de consumo de tabaco sin humo y el desarrollo de lesiones orales asociadas a su uso continuado. Se estima que el 90% de los consumidores de las formas de tabaco sin humo se encuentran en el Sur de Asia, lo que supone una cifra de 100 millones de personas. En general, el tabaquismo comienza a una edad joven y se sabe que aumenta el riesgo de padecer enfermedades crónicas durante toda la vida (AU)


Tobacco consumption and, in particular, smokeless forms are determinant in the development of oral carcinoma and oral submucosal fibrosis, among other entities. The aim of this paper is to review the existing literature on the different forms of smokeless tobacco use and the development of oral lesions associated with its continued use. It is estimated that 90% of consumers of smokeless tobacco are found in South Asia, which represents a figure of 100 million people. In general, smoking begins at a young age and is known to increase the risk of chronic diseases throughout life (AU)


Assuntos
Humanos , Tabaco sem Fumaça/efeitos adversos , Boca/patologia , Carcinoma/epidemiologia , Fibrose Oral Submucosa/patologia , Neoplasias Bucais/epidemiologia , Poluição por Fumaça de Tabaco , Tabaco sem Fumaça , Doenças Periodontais/patologia
15.
Med. oral patol. oral cir. bucal (Internet) ; 22(6): e708-e715, nov. 2017. graf, tab
Artigo em Inglês | IBECS | ID: ibc-168746

RESUMO

Background: Obesity is a very prevalent chronic disease worldwide and has been suggested to increase susceptibility of periodontitis. The aim of this paper was to provide a systematic review of the association between obesity and periodontal disease, and to determine the possible mechanisms underlying in this relationship. Material and Methods: A literature search was carried out in the databases PubMed-Medline and Embase. Controlled clinical trials and observational studies identifying periodontal and body composition parameters were selected. Each article was subjected to data extraction and quality assessment. Results: A total of 284 articles were identified, of which 64 were preselected and 28 were finally included in the review. All the studies described an association between obesity and periodontal disease, except two articles that reported no such association. Obesity is characterized by a chronic subclinical inflammation that could exacerbate other chronic inflammatory disorders like as periodontitis. Conclusions: The association between obesity and periodontitis was consistent with a compelling pattern of increased risk of periodontitis in overweight or obese individuals. Although the underlying pathophysiological mechanism remains unclear, it has been pointed out that the development of insulin resistance as a consequence of a chronic inflammatory state and oxidative stress could be implicated in the association between obesity and periodontitis. Further prospective longitudinal studies are needed to define the magnitude of this association and to elucidate the causal biological mechanisms (AU)


No disponible


Assuntos
Humanos , Doenças Periodontais/epidemiologia , Obesidade/complicações , Periodontite/epidemiologia , Estudos Epidemiológicos , Doenças Periodontais/diagnóstico , Bibliometria , Estudos Prospectivos , Estudos Longitudinais
16.
Med. clín (Ed. impr.) ; 149(7): 305-309, oct. 2017. tab
Artigo em Espanhol | IBECS | ID: ibc-166748

RESUMO

Los avances en los estudios de genética y epigenética modifican algunos conceptos de salud y enfermedad que se habían mantenido intactos durante décadas. En este sentido, en los últimos años se está otorgando un protagonismo creciente a microorganismos que han acompañado durante millones de años de evolución a los seres vivos superiores. Los genes de estos y de su microbiota constituyen un microbioma que interviene en el mantenimiento de la salud. La boca es lugar de asiento de gran variedad de microorganismos, cuyo control ayuda a estabilizar la enfermedad oral y sistémica. El objetivo del presente artículo es actualizar algunos conceptos relativos al microbioma oral y de su vinculación con la salud oral y general (AU)


Advances in genetic and epigenetic studies modified some concepts of health and disease that had been kept intact for decades. In this respect, in the last few years, microorganisms that have evolved with superior life forms for millions of years have taken an increased prominence. The genes of organisms and their microbiota constitute a microbiome that intervenes in health maintenance. The oral cavity is inhabited by a variety of microorganisms, their control aids in stabilising oral and systemic disease. The objective of this article is to update some concepts related to oral microbiome and its correlation with general and oral health (AU)


Assuntos
Humanos , Microbiota , Boca/microbiologia , Placa Dentária/microbiologia , Saliva/microbiologia , Saúde Bucal , Doenças da Boca/microbiologia , Doenças Periodontais/microbiologia , Biofilmes/crescimento & desenvolvimento
17.
Med. oral patol. oral cir. bucal (Internet) ; 22(5): e586-e594, sept. 2017. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-166653

RESUMO

Background: Diabetes Mellitus has become a global epidemic and presents many complications, usually proportional to the degree and duration of hyperglycemia. The aim of this systematic review was to investigate the different oral manifestations associated with Diabetes Mellitus. Material and Methods: A MEDLINE search for "Diabetes Mellitus and oral manifestations" was performed. A further search was conducted for "diabetes" and its individual oral manifestation. Inclusion criteria were as follows: human clinical studies with a minimum of 30 patients; studies published in relevant scientific journals between January 1998 and January 2016. Nineteen studies fulfilled the inclusion criteria and were analyzed, assessing the strength of scientific evidence according to recommendations made by the Centre for Evidence-Based Medicine, Oxford (OCEBM), which permits adequate assessment of prevalence studies. Results: A total 3,712 patients (2,084 diabetics) were included in the studies reviewed. Of the 19 studies analyzed, 4 were longitudinal studies and 15 cross-sectional studies. Periodontal disease, periapical lesions, xerostomia and taste disturbance were more prevalent among diabetic patients. An association between diabetes and caries and mucosal lesions proved positive in 5 out of 10 studies. Conclusions: Despite multiple oral manifestations associated with DM, awareness of the associations between diabetes, oral health, and general health is inadequate. It is necessary for doctors and dentists to be aware of the various oral manifestations of diabetes in order to make an early diagnosis (AU)


No disponible


Assuntos
Humanos , Complicações do Diabetes/epidemiologia , Diabetes Mellitus/fisiopatologia , Doenças da Boca/complicações , Cárie Dentária/epidemiologia , Doenças Periodontais/epidemiologia , Doenças Periapicais/epidemiologia , Xerostomia/epidemiologia , Distúrbios do Paladar/epidemiologia
18.
Cient. dent. (Ed. impr.) ; 14(2): 129-134, mayo-ago. 2017. ilus
Artigo em Espanhol | IBECS | ID: ibc-165677

RESUMO

La osteonecrosis de los maxilares (ONM) inducida por fármacos antirresortivos, principalmente los bifosfonatos (BF), está ampliamente descrita en la literatura científica. En los últimos años se han publicado algunos casos de ONM inducidas por otros medicamentos antirresortivos como Denosumab, Bevacizumab y Sunitinib utilizados en pacientes oncológicos. Denosumab es un anticuerpo monoclonal que se utiliza en el tratamiento de la osteoporosis y en la prevención de fracturas tras el tratamiento de algunos tipos cáncer. En este artículo, presentamos el caso de una paciente que desarrolló ONM. La paciente tenía enfermedad periodontal y osteoporosis, que había sido tratada durante años con Alendronato (bifosfonato oral) y actualmente con Denosumab. Además, era portadora de una prótesis removible mal adaptada. En el presente trabajo se discute el riesgo de ONM asociada a estos fármacos, y la posible influencia en su aparición de ciertos factores a nivel local, así como las medidas preventivas y terapéuticas que se deberán adoptar en estos casos (AU)


Osteonecrosis of the jaw (ONJ) induced by antiresorptive drugs, mainly bisphosphonates (BF), is widely described in the scientific literature. In recent years, there have been reports of ONJ induced by other antiresorptive drugs such as Denosumab, Bevacizumab and Sunitinib used in cancer patients. Denosumab is a monoclonal antibody that is used in the treatment of osteoporosis and in the prevention of fractures following the treatment of some types of cancer. In this article, we present the case of a patient who developed ONJ. The patient had periodontal disease and osteoporosis, which had been treated for years with Alendronate (oral bisphosphonate) and currently with Denosumab. In addition, she had a poorly adapted removable prosthesis. This work discusses the risk of ONJ associated with these drugs, and the possible influence on their occurrence of certain factors at the local level, as well as the preventive and therapeutic measures that should be adopted in these cases (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/diagnóstico , Difosfonatos/efeitos adversos , Osteoporose/tratamento farmacológico , Alendronato/uso terapêutico , Denosumab/uso terapêutico , Doenças Periodontais/complicações
19.
Med. oral patol. oral cir. bucal (Internet) ; 22(4): e425-e431, jul. 2017. tab
Artigo em Inglês | IBECS | ID: ibc-164942

RESUMO

Background: The validity of the surveys on self-reported smoking status is often questioned because smokers underestimate cigarette use and deny the habit. It has been suggested that self-report should be accompanied by cotinine test. This report evaluates the usefulness of serum cotinine test to assess the association between smoking and periodontal status in a study with a large sample population to be used in studies with other serum markers in epidemiologic and periodontal medicine researches. Material and Methods: 578 patients who were part of a multicenter study on blood biomarkers were evaluated about smoking and its relation to periodontal disease. Severity of periodontal disease was determinate using clinical attachment loss (CAL). Smoking was assessed by a questionnaire and a blood sample drawn for serum cotinine determination. Results: The optimal cut-off point for serum cotinine was 10 ng/ml. Serum cotinine showed greater association with severity of CAL than self-report for mild-moderate CAL [OR 2.03 (CI95% 1.16-3.53) vs. OR 1.08 (CI95% 0.62-1.87) ] advanced periodontitis [OR 2.36 (CI95% 1.30- 4.31) vs. OR 2.06 (CI95% 0.97-4.38) ] and extension of CAL > 3 mm [ OR 1.78 (CI95% 1.16-1.71) vs. 1.37 (CI95% 0.89-2.11)]. When the two tests were evaluated together were not shown to be better than serum cotinine test. Conclusions: Self-reported smoking and serum cotinine test ≥ 10ng/ml are accurate ,complementary and more reliable methods to assess the patient’s smoking status and could be used in studies evaluating serum samples in large population and multicenter studies. Clinical Relevance: The serum cotinine level is more reliable to make associations with the patient’s periodontal status than self-report questionnaire and could be used in multicenter and periodontal medicine studies (AU)


No disponible


Assuntos
Humanos , Fumar/efeitos adversos , Tabagismo/epidemiologia , Doenças Periodontais/epidemiologia , Cotinina/farmacocinética , Biomarcadores/análise , Periodontite/etiologia
20.
Med. oral patol. oral cir. bucal (Internet) ; 22(4): e432-e439, jul. 2017. graf, tab
Artigo em Inglês | IBECS | ID: ibc-164943

RESUMO

Background: Periodontal diseases have systemic inflammatory effects and have been adversely associated with cardiovascular diseases, which are also the most frequent cause of death in the end-stage renal disease. The aim of this cross-sectional study was to investigate the oral health and serum biomarkers among the hemodialysis (HD) patients in Slovenia. Material and Methods: 111 HD patients were periodontally examined and their sera were assayed for C-reactive protein (CRP), cardiac troponin T (TnT), nitrite/nitrate (NOx) and antibody levels to A. actinomycetemcomitans and P. gingivalis. The association of oral health with systemic response was analyzed with Kruskal-Wallis test, Fisher’s exact test and multivariate linear regression. Results: Bleeding on probing without periodontal pockets was present in 5.2%, calculus without periodontal pockets in 42.1%, shallow periodontal pockets in 39.5% and deep periodontal pockets in 13.2% of dentate patients. There were 28.8% edentulous participants. 63.1% of the patients had CRP levels higher than 3 mg/L and 34.2% higher than 10 mg/L. TnT was detectable in all participants, with 25.2% exhibiting levels higher than 100 ng/L. The median level of NOx was 43.1 µmol/L. Participants with higher CRP were more likely to be edentulous and have higher TnT levels. A direct association of oral health with TnT or NOx was not detected. Conclusions: HD patients in Slovenia have compromised oral health and increased serum inflammatory and cardiac biomarkers. Edentulousness was an independent predictor for the increased CRP, indicating a need for improved dental care to retain the teeth as long as possible (AU)


No disponible


Assuntos
Humanos , Diálise Renal , Doenças Periodontais/epidemiologia , Inflamação/fisiopatologia , Biomarcadores/análise , Saúde Bucal , Mediadores da Inflamação/análise , Troponina T/análise , Cardiomiopatia Hipertrófica/epidemiologia , Hipertensão/epidemiologia , Proteína C-Reativa/análise , Eslovênia/epidemiologia , Boca Edêntula/epidemiologia , Estudos Transversais
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