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1.
Cient. dent. (Ed. impr.) ; 17(1): 41-48, ene.-abr. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-189748

RESUMO

INTRODUCCIÓN: La gingivitis, si no se trata, puede provocar una periodontitis irreversible. Uno de los compuestos destinados a combatirla es el o-cymen-5-ol. OBJETIVO: El objetivo principal de este estudio fue demostrar la respuesta clínica de un dentífrico con o-cymen-5-ol al 0,1% más zinc, aplicado durante 7 días consecutivos al menos 2 veces/día, en pacientes con un índice de sangrado del surco gingival ≥ 25%. Como objetivo secundario se evaluó la tolerancia del producto. MÉTODOS: Estudio prospectivo, aleatorizado, doble ciego y controlado, para evaluar la eficacia de una pasta dental o-cymen-5-ol frente a un dentífrico con triclosán al 0,3% más zinc. Tras la visita basal, los datos se evaluaron a las 38 h., 48 h., 4 días y 7 días. Se emplearon modelos lineales de efectos mixtos, que fueron ajustados a los datos del ensayo para evaluar la respuesta del producto a lo largo del tiempo Resultados: Se incluyó a un total de 49 pacientes. El porcentaje medio de sangrado basal en ambos grupos fue homogéneo. Respecto al inicio del tratamiento, ambos grupos experimentaron una reducción significativa del índice de sangrado a las 38 horas. Esta reducción continuó ampliándose significativamente hasta un 67,5% y un 71,8%, respectivamente, a los 7 días del inicio del tratamiento. CONCLUSIONES: La pasta dental con o-cy-men-5-ol al 0,1% más zinc mejora el índice de sangrado gingival de forma significativa, ya a las 38 horas de aplicación, en individuos con un índice basal ≥25%, de forma similar a una pasta dental con triclosán al 0,3% más zinc


INTRODUCTION: Gingivitis, if not treated, can cause irreversible periodontitis. One of the compounds used to fight it is o-cymen-5-ol. OBJECTIVE: The main objective of this study was to demonstrate the clinical response of a toothpaste with o-cymen-5-ol at 0.1% plus zinc, applied during 7 consecutive days at least twice a day, in patients with a bleeding rate of the gingival sulcus ≥ 25%. As a secondary objective, the tolerance of the product is evaluated. METHODS: A prospective, randomised, double blind and controlled study, to evaluate the effectiveness of a toothpaste with o-cymen-5-ol compared to a toothpaste with triclosan at 0.3% plus zinc. After the baseline visit, the data were evaluated at 38 h, 48 h, 4 days and 7 days. Linear models of mixed effects were used, which were adjusted to the trial data in order to evaluate the response of the product in a study over time. RESULTS: A total of 49 patients were included. The average baseline percentage in both groups was homogeneous. With respect to the start of the treatment, both groups experienced a significant reduction in the bleeding rate at 38 h. This continuous reduction increased significantly up to 67.5% and 71.8%, respectively, at 7 days from the start of the treatment. CONCLUSIONS: Toothpaste with o-cymen-5-ol at 0.1% plus zinc improves the gingival bleeding rate significantly, with just 38 hours of application, in individuals with a baseline rate ≥ 25%, similarly to toothpaste with triclosan at 0.3% plus zinc


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Hemorragia Gengival/terapia , Cremes Dentais/uso terapêutico , Resultado do Tratamento , Cloretos/uso terapêutico , Tolerância a Medicamentos , Estudos Prospectivos , Análise Estatística , Triclosan/uso terapêutico , Periodontite/complicações , Cremes Dentais/farmacocinética
2.
Nutr. hosp ; 36(5): 1095-1100, sept.-oct. 2019. graf
Artigo em Espanhol | IBECS | ID: ibc-184632

RESUMO

Introducción: el principal problema de salud pública en México es la obesidad y sus enfermedades asociadas, incluyendo las bucales. Objetivo: evaluar el efecto del tratamiento con metformina en pacientes obesos de clase I sobre la actividad de las metaloproteinasas presentes en el periodonto con periodontitis crónica. Métodos: se realizó un estudio clínico con 68 pacientes mujeres con obesidad de clase I y enfermedad periodontal. Se dividieron en 4 grupos; a 2 de ellos, además del tratamiento periodontal, se les administro metformina de 850 mg al día durante seis semanas. Se tomaron 2 muestras por paciente de tejido periodontal antes y después de cada tratamiento y se midió el índice de masa corporal (IMC), el índice de placa dentobacteriana y de inflamación. Mediante zimografía en gel de acrilamida se midió la actividad de las metaloproteinasas en la muestra de tejido recolectada. Los datos obtenidos fueron analizados mediante estadística descriptiva t de student para muestras relacionadas y se realizó ANOVA de una vía considerando p < 0,01 como estadísticamente significativa. Resultados: en el grupo de pacientes a las que se les administro metformina al final del tratamiento se observó una disminución del índice de masa corporal, del grado de inflamación y menor actividad de metaloproteinasas respecto al grupo control (65% frente a 25%; p < 0,01). Conclusiones: el tratamiento con metformina en pacientes con obesidad de clase I y enfermedad periodontal disminuye el IMC, mejora los síntomas de la periodontitis crónica y disminuye la actividad de las metaloproteinasas 1, 3, 8 y V presentes en el periodonto de estos pacientes


Introduction: in Mexico the main problem in public health is obesity and other diseases that are associated whit this condition, including oral health. Objective: to evaluate the effect of metformin treatment in patients with class I obese on the activity of metalloproteinases present in periodontium with chronic periodontitis. Methods: a clinical study was conducted in 68 patients with class I obesity and periodontal disease. They were divided into 4 groups. 2 of them, in addition to the periodontal treatment, were administered metformin 850 mg per day for six weeks; 2 samples were taken per patient of periodontal tissue before and after each treatment, body mass index, plaque index and inflammation were measured. Acrylamide gel zymography was used to measure the activity of metalloproteinases in the sample of tissue collected. The data obtained were analyzed by descriptive statistics, student t for related samples and one-way ANOVA was performed considering p < 0.01 as statistically significant. Results: in the group of patients who were administered metformin at the end of the treatment, there was a decrease in the body mass index, the degree of inflammation and lower metalloproteinase activity, compared with the control group (65% vs 25%; < 0.01). Conclusions: treatment with metformin in patients with obesity class I and periodontal disease decreases BMI, improves the symptoms of chronic periodontitis and decreases the activity of metalloproteinases 1, 3, 8, V present in periodontium of these patients


Assuntos
Humanos , Feminino , Adulto , Obesidade/tratamento farmacológico , Obesidade/enzimologia , Metformina/administração & dosagem , Metaloproteases/metabolismo , Periodontite/complicações , Periodontite/diagnóstico , Metformina/metabolismo , Periodontite/terapia , Análise de Variância , Placa Dentária/diagnóstico , Índice de Placa Dentária
3.
Med. oral patol. oral cir. bucal (Internet) ; 24(5): e659-e672, sept. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-185685

RESUMO

Background: Despite decades of research, our knowledge of several important aspects of periodontal pathogenesis remains incomplete. Epigenetics allows to perform dynamic analysis of different variations in gene expression, providing this great advantage to the static measurement provided by genetic markers. The aim of this systematic review is to analyze the possible relationships between different epigenetic mechanisms and periodontal diseases, and to assess their potential use as biomarkers of periodontitis. Material and Methods: A systematic search was conducted in six databases using MeSH and non-MeSH terms. The review fulfilled PRISMA criteria (Preferred Reporting Items for Systematic reviews and Meta-analysis). Results: 36 studies met the inclusion criteria. Due to the heterogeneity of the articles, it was not possible to conduct quantitative analysis. Regarding qualitative synthesis, however, it was found that epigenetic mechanisms may be used as biological markers of periodontal disease, as their dynamism and molecular stability makes them a valu-able diagnostic tool. Conclusions: Epigenetic markers alter gene expression, producing either silencing or over-expression of molecular transcription that respond to the demands of the cellular surroundings. Gingival crevicular fluid collection is a non-invasive and simple procedure, which makes it an ideal diagnostic medium for detection of both oral and systemic issues. Although further research is needed, this seems to be a promising field of research in the years to come


No disponible


Assuntos
Humanos , Doenças Periodontais , Periodontite , Epigênese Genética , Líquido do Sulco Gengival , Periodontia
4.
Cient. dent. (Ed. impr.) ; 15(3): 173-178, sept.-dic. 2018. ilus
Artigo em Espanhol | IBECS | ID: ibc-182249

RESUMO

Desde hace bastantes años, se ha asociado regularmente el abuso del cannabis, y sobre todo en su forma más habitual, la marihuana, con una boca más descuidada. Los adictos al cannabis suelen tener mayores índices de placa, xerostomía y caries. Sin embargo, son pocas las publicaciones que relacionan la marihuana con enfermedad periodontal, salvo casos clínicos aislados. En este artículo, se revisa la literatura que existe al respecto y se presentan tres casos clínicos de pacientes fumadores habituales de marihuana con periodontitis


The abuse of cannabis, overall in its most habitual format, marihuana, has commonly been related to oral neglect. Cannabis abusers have higher plaque scores, xerostomia and increase in the risk of dental caries. Nevertheless, there are few the papers that show a relationship between marihuana and periodontal disease, except in isolated clinical cases. In this article, literatura related to the topic is revised and three cases report of habitual smokers of marihuana with necrotizing periodontitis are shown


Assuntos
Humanos , Masculino , Adulto , Doenças Periodontais/induzido quimicamente , Doenças Periodontais/diagnóstico , Cannabis/efeitos adversos , Periodontite/complicações , Periodontite/etiologia , Gengivite Ulcerativa Necrosante/complicações , Gengivite Ulcerativa Necrosante/etiologia , Abuso de Maconha/complicações
5.
Ars pharm ; 59(4): 235-250, oct.-dic. 2018. tab
Artigo em Espanhol | IBECS | ID: ibc-177739

RESUMO

Objetivos: La enfermedad periodontal es una de las enfermedades orales crónicas más comunes en todo el mundo y representa un importante problema de salud pública en muchos países. Las enfermedades periodontales incluyen periodontitis crónica y periodontitis agresiva que generalmente se debe a la inflamación de la encía causada por infecciones bacterianas. La nutrición podría ejercer un papel fundamental ya que participa en diferentes afecciones y enfermedades inflamatorias. Hasta ahora, solo algunos investigadores han investigado el papel de los nutrientes en el desarrollo y la progresión de la enfermedad periodontal, pero los resultados obtenidos a menudo son difíciles de comparar debido a la heterogeneidad de los estudios. Métodos: Este documento revisa sistemáticamente la literatura disponible en bases de datos hasta Febrero de 2018 sobre la relación entre macronutrientes y el desarrollo y progresión de enfermedades periodontales (periodontitis y gingivitis) en animales, con particular atención a los posibles mecanismos implicados en estas patologías. Resultados: Se encontraron un total de 5.484 publicaciones en la base de datos Pubmed. El análisis del título y resumen permitió seleccionar 88 artículos potenciales de acuerdo con los criterios de selección. No se encontraron artículos duplicados. La selección y lectura del texto complejo condujo a una cantidad final de 32 artículos. Conclusiones: Entre todos los macronutrientes analizados, aquellos que tienen algún efecto sobre el estrés oxidativo o el sistema inmune parecen ser importantes para la prevención de la enfermedad periodontal o la mejoría de la enfermedad periodontal. Por un lado, hay evidencia a favor de un papel positivo de la proporción de ácidos grasos n-3 en la dieta debido a sus efectos antioxidantes e inmunomoduladores. Por otro lado, las dietas ricas en grasas saturadas o hipercalóricas aumentan el estrés oxidativo o promueven la inflamación, por lo que deben evitarse


Objectives: Periodontal disease is one of the most common chronic oral diseases worldwide and represents a major public health problem in many countries. Periodontal diseases include chronic periodontitis and aggressive periodontitis that are usually due to the inflammation of gingiva caused by bacterial infections. Nutrition could exert a pivotal role due to its involvement in a number of inflammatory condition and diseases. Up to now, only some researchers have investigated the role of nutrients on the development and progression of periodontal disease, but the results obtained are often difficult to compare because of the heterogeneity of the studies. Methods: This paper systemically reviews the literature available on databases up to February 2018 on the relationship between macronutrients and the development and progression of periodontal diseases (periodontitis and gingivitis) in animals, with particular attention to the possible mechanisms involved in these pathologies. Results: A total of 5,484 publications were found in the Pubmed database. Title and abstract screening left 88 potential articles according to the selection criteria. No duplicated articles were found. Full-text screening and reading led to a final number of 32 articles. Conclusions: Among all the analyzed macronutrients, those that have any effect on oxidative stress or immune system seem to be important for the prevention of periodontal disease or periodontal disease improvement. On the one hand, there is evidence in favor of a positive role of n-3 fatty acid proportion in diet due to its antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich or hypercaloric diets increase oxidative stress or promote inflammation, so they must be avoided


Assuntos
Animais , Ratos , Nutrientes , Modelos Animais , Doenças Periodontais/terapia , Periodontite/terapia , Gengivite/terapia , Gengivite/veterinária , Saúde Pública , Infecções Bacterianas/terapia , Infecções Bacterianas/veterinária , Ratos Wistar
6.
Neurología (Barc., Ed. impr.) ; 33(9): 602-613, nov.-dic. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-176006

RESUMO

INTRODUCCIÓN: La enfermedad periodontal y la demencia son enfermedades muy prevalentes, especialmente en poblaciones envejecidas. Numerosos estudios han demostrado una relación entre ambas afecciones, pero la alta heterogeneidad en el diagnóstico, así como la metodología empleada, pueden dificultar la interpretación y la comparación de los resultados obtenidos. El objetivo de este artículo es realizar una revisión crítica de las publicaciones que asocian ambos procesos. DESARROLLO: Se incluyen 22 artículos, mayoritariamente estudios retrospectivos, y se analizan diversas variables metodológicas, como población de estudio, diagnóstico de periodontitis, definición de demencia, variables ajustadas y resultados. Además, se analizan los diferentes mecanismos etiopatogénicos que pueden influir en la progresión de ambas enfermedades y en la interacción entre ellas. CONCLUSIONES: Aunque la evidencia disponible indica una tendencia positiva a la asociación entre periodontitis y demencia, se desconoce el grado de esta asociación y la existencia de una relación causal entre ambas enfermedades


INTRODUCTION: Periodontal disease and dementia are very prevalent, especially in elderly populations. Multiple studies have shown a link between these diseases; however, the conditions are highly heterogeneous and so is the diagnostic methodology, which may hinder interpretation and comparison of the results. The aim of this article is to provide a critical review of the literature linking these 2 processes. DEVELOPMENT: We retrieved 22 studies, most of which were retrospective, and analysed various methodological variables including study population, diagnosis of periodontitis, definition of dementia, adjusted variables, and results. The different aetiopathogenic mechanisms that may affect the progression and interaction of these 2 conditions were also analysed. CONCLUSIONS: Although available evidence indicates a positive association between periodontitis and dementia, both the strength of that association and the presence of a causal relationship have yet to be determined


Assuntos
Humanos , Demência/epidemiologia , Doenças Periodontais/epidemiologia , Fatores de Risco , Periodontite/epidemiologia , Demência/psicologia , Doenças Periodontais/psicologia , Estudos Retrospectivos
7.
Med. oral patol. oral cir. bucal (Internet) ; 23(5): e569-e578, sept. 2018. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-176376

RESUMO

Background: Aggregatibacter-actinomycetemcomitans (A.actinomycetemcomitans) are strongly associated with localized-aggressive-periodontitis (LAgP). The study's aim was to test for the first time the effect of total sonicated A.actinomycetemcomitans-bacterial-fragments on gingival mesenchymal stem/progenitor cells' (G-MSCs) proliferation and regenerative gene expression in-vitro. Material and Methods: G-MSCs were isolated, characterized, expanded and stimulated by total sonicated A.actinomycetemcomitans-bacterial-fragments (0 (negative-control), 15, 60, 120 and 240μg/ml; serovar-b; n=6/group). Cellular proliferation and NF-κβ (NFKB1), Alkaline Phosphatase (ALPL), Collagen-I (COL1A1), Collagen-III (COL3A1), Osteonectin (SPARC) and Osteopontin (SPP1) m-RNA expression were assessed via reverse-transcription-polymerase-chain-reaction (RT-PCR) at 24, 48 and 72 hours and CFUs-ability evaluated at twelve days. Results: G-MSCs demonstrated stem/progenitor cells' characteristics. A.actinomycetemcomitans-bacterial-fragments (up to 72 hours) resulted in marked G-MSCs' proliferation over-time (p<0.001) and elevated NFKB1 (p= 0.017), COL1A1 (p=0.025), SPARC (p=0.025), decreased ALPL (p=0.017), with no significant differences for COL3A1 and SPP1 expression or stimulation times (p>0.05; Friedman-test). Longer-term stimulation for twelve days reduced G-MSCs' CFUs. Conclusions: Sonicated A.actinomycetemcomitans-bacterial-fragments' exert beneficial short-term effects on G-MSCs' proliferative and non-mineralized tissue forming aptitude. Results shed new light on the importance of periodontal treatment for LAgP patients, using power driven sonic/ultrasonic devices, which, in addition to reducing the subgingival microbial load, produces cell-stimulatory A.actinomycetemcomitans-bacterial-fragments, with positive attributes on tissue reparative/regenerative responses of tissue resident stem/progenitor cells in their niche


No disponible


Assuntos
Humanos , Aggregatibacter actinomycetemcomitans/isolamento & purificação , Infecções por Pasteurellaceae/patologia , Células-Tronco/microbiologia , Gengiva/microbiologia , Periodontite/microbiologia , Periodontite/patologia , Proliferação de Células , Fatores Estimuladores de Colônias
8.
Rev. iberoam. micol ; 35(3): 134-139, jul.-sept. 2018. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-179573

RESUMO

Background: Candida can be implicated in the pathology of chronic periodontitis. Aims: To analyze the oral Candida carriage in patients suffering from chronic periodontitis (CP) and its correlation with the severity of this condition. Methods: Microbiological samples were taken from 155 patients using the oral rinse (OR) technique and by using paper points in the periodontal pockets (GPP). These patients were divided into 3 groups: 89 patients without CP (control), 47 with moderate CP, and 19 with severe CP. Samples were cultured in a Candida chromogenic agar for Candida. Species were identified by microbiological and molecular methods. Results: Candida was isolated in the OR of 45 (50.6%), 21 (44.7%), and 11 (57.9%) patients, respectively, and in the GPP of 32 (36%), 14 (29.2%), and 10 (42.6%) patients from the control, moderate CP and severe CP groups, respectively. Candida was isolated more frequently and in a greater burden in OR than in GPP (p<0.01). Candida albicans was the most prevalent species. GPP of patients with CP had poor fungal biodiversity (p<0.01). Conclusions: Colonization by Candida was present in the samples of patients without CP, and with both moderate and severe CP. Nonetheless, patients with severe CP had a higher rate of Candida colonization, especially by C. albicans


Antecedentes: Candida puede estar implicada en la patogenia de la enfermedad periodontal crónica. Objetivos: Analizar la colonización oral por Candida en pacientes con enfermedad periodontal (EP) crónica y su asociación con la gravedad de esta entidad clínica. Métodos: Se tomaron muestras microbiológicas de 155 pacientes mediante enjuagues orales e introduciendo una punta de papel estéril en la bolsa periodontal. Se dividieron los pacientes en tres grupos: 89 pacientes sin EP (control), 47 con EP moderada y 19 con EP grave. Las muestras se cultivaron en un agar cromógeno para Candida y las especies se identificaron mediante métodos microbiológicos tradicionales y moleculares. Resultados: Se aisló Candida en los enjuagues de 45 (50,6%), 21 (44,7%) y 11 (57,9%) pacientes y en las puntas de papel de 32 (36%), 14 (29,2%) y 10 (42,6%) pacientes de los grupos control, con EP moderada y con EP grave, respectivamente. Candida se aisló con mayor frecuencia y mayor carga fúngica en las muestras de los enjuagues que en las de las puntas de papel (p < 0,01). Candida albicans fue la especie más prevalente. Las muestras de la bolsa periodontal de los pacientes con EP presentaron una baja biodiversidad fúngica (p??0,01). Conclusiones: Hubo colonización por Candida en las muestras de pacientes sin EP y con EP tanto moderada como leve. No obstante, los pacientes con EP grave presentaron una mayor colonización por Candida, especialmente por C. albicans


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Periodontite Crônica/microbiologia , Candida/isolamento & purificação , Candidíase Bucal/epidemiologia , Técnicas de Tipagem Micológica/métodos , Periodontite/epidemiologia , Candida/patogenicidade , Índice Periodontal , Índice de Gravidade de Doença
9.
Med. oral patol. oral cir. bucal (Internet) ; 23(3): e269-e276, mayo 2018. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-175876

RESUMO

Background: Periodontitis is a chronic disease that due to an intense inflammatory response triggers systemic changes such as hepatic alterations. This study aimed to compare hepatic damage in rats that received experimental periodontitis at one or two periodontal sites with ligatures. Material and Methods: Eighteen rats were separated into three groups: control, without ligature; periodontitis 1, with one ligature; and periodontitis 2, with two ligatures. The following parameters were assessed: gingival bleeding index, probing pocket depth, tooth mobility, alveolar bone loss, malondialdehyde (MDA) and myeloperoxidase (MPO) activity in periodontal tissue; histopathological evaluation of hepatic tissue (steatosis score); glutathione levels (GSH), MDA, MPO, cholesterol and triglycerides in the liver; and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Results: Periodontal evaluation data showed that the periodontitis model worked well. The groups with periodontitis did not differ significantly in relation to MPO activity and MDA levels in the gingival samples, but they were significantly different when compared with the control group. Steatosis was observed in the histological analysis of the groups with periodontitis, but between the periodontitis groups, two ligatures did not cause increase in steatosis score. The levels of GSH, MDA, total cholesterol and triglycerides in the hepatic tissue were not altered between groups with periodontitis, but they showed significant differences in comparison with the control group. The activity of MPO in hepatic tissue and serum levels of AST and ALT did not present significant difference among the three groups. Conclusions: In conclusion, our results demonstrated that one or two ligatures inducing periodontitis were both sufficient to cause fatty liver. Steatosis caused by two ligatures did not present larger extension and severity than steatosis caused by one ligature


No disponible


Assuntos
Animais , Feminino , Ratos , Fígado Gorduroso/etiologia , Periodontite/complicações , Periodontite/etiologia , Ligadura , Ratos Wistar
10.
Med. oral patol. oral cir. bucal (Internet) ; 23(3): e335-e343, mayo 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-175886

RESUMO

Background: The present study was carried out to evaluate the possible association between obesity and periodontitis in patients with DS, and to explore which measure of obesity is most closely correlated to periodontitis. Material and Methods: A prospective observational study was made to determine whether obesity is related to periodontal disease in patients with DS. The anthropometric variables were body height and weight, which were used to calculate BMI and stratify the patients into three categories: < 25(normal weight), 25-29.9 (overweight) and ≥ 30.0 kg/m2 (obese). Waist circumference and hip circumference in turn was recorded as the greatest circumference at the level of the buttocks, while the waist/hip ratio (WHR) was calculated. Periodontal evaluation was made of all teeth recording the plaque index (PI), pocket depth (PD), clinical attachment level (CAL) and the gingival index. We generated a multivariate linear regression model to examine the relationship between PD and the frequency of tooth brushing, gender, BMI, WHI, WHR, age and PI. Results: Significant positive correlations were observed among the anthropometric parameters BMI, WHR, WHI and among the periodontal parameters PI, PD, CAL and GI. The only positive correlation between the anthropometric and periodontal parameters corresponded to WHR. Upon closer examination, the distribution of WHR was seen to differ according to gender. Among the women, the correlation between WHR and the periodontal variables decreased to nonsignificant levels. In contrast, among the males the correlation remained significant and even increased. In a multivariate linear regression model, the coefficients relating PD to PI, WHR and age were positive and significant in all cases. Conclusions: Our results suggest that there may indeed be an association between obesity and periodontitis in male patients with DS. Also, we found a clear correlation with WHR, which was considered to be the ideal adiposity indicator in this context


No disponible


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Síndrome de Down/complicações , Obesidade/complicações , Periodontite/etiologia , Estudos Prospectivos
11.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 44(2): 138-143, mar. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-174380

RESUMO

Se ha constatado en el embarazo la asociación entre problemas de salud oral y complicaciones obstétricas. Por ello, el objetivo principal de este trabajo es evaluar en embarazadas la percepción de salud oral, hábitos y creencias relativas. Se diseñó un cuestionario para obtener información de las embarazadas que acudían a la consulta de Obstetricia del Hospital Comarcal Valdeorras y Odontología de atención primaria del Centro de Salud Valle Inclán (n=96). Se encontró que la percepción propia de muchas gestantes era padecer algún problema en la cavidad oral. Además, se reflejó que las gestantes tenían hábitos relativos a salud oral adecuados; en adición, creían que su embarazo iba a traer implícitamente problemas a su boca. Las gestantes son capaces de comprender la relación entre su salud oral, su salud sistémica y la de su futuro hijo. Se detectaron una serie de hábitos y creencias en las que sería conveniente incidir para reducir problemas sanitarios


An association has been found between oral health problems and obstetric complications during pregnancy. The main aim of this study was to assess the perception by pregnant women on their oral health and related habits and beliefs. A questionnaire was designed in order to obtain information from 96 pregnant women attending the Valdeorras Local Hospital and the primary health dental practice in the Valle Inclan Health Center. It was found that many pregnant women perceived they were suffering from some kind of problem affecting their mouth. It was shown that pregnant women had adequate habits regarding oral health, but they believed that their pregnancy would implicitly cause them to have mouth problems. Pregnant women are able to understand the impact of their oral health on their general well-being and the health of their unborn child. It has been detected that a series of habits and beliefs would ideally need to be acted upon in order to reduce health problems


Assuntos
Humanos , Feminino , Gravidez , Adulto , Pessoa de Meia-Idade , Hábitos , Saúde Bucal , Atenção Primária à Saúde/métodos , Odontologia Preventiva/métodos , Profilaxia Dentária/métodos , Gengivite/epidemiologia , Avaliação em Saúde , Nível de Saúde , Periodontite/epidemiologia , Inquéritos e Questionários , Estudos Transversais/métodos , População Urbana/estatística & dados numéricos , Hemorragia Gengival/complicações
13.
Cient. dent. (Ed. impr.) ; 14(3): 167-172, sept.-dic. 2017. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-170385

RESUMO

La periodontitis es una infección polimicrobiana caracterizada por un proceso inflamatorio destructivo que resulta en la pérdida de los tejidos que sostienen los dientes. uno de sus principales agentes etiológicos, Porphyromonas gingivalis, es capaz de adherirse y formar un biofilm o placa, contribuyendo a la colonización de la cavidad bucal. También sintetiza proteasas que pueden degradar proteínas tisulares y plasmáticas, que contribuyen a la invasión de los tejidos periodontales. Los procedimientos habituales para evitar el progreso de la enfermedad periodontal no siempre consiguen el resultado clínico deseado. Sin embargo, varios estudios indican que los polifenoles del arándano, concretamente las proantocianidinas (PAC), pueden inhibir la formación de placa dental, la producción de ácido y de enzimas proteolíticas derivadas de distintos patógenos periodontales, así como la respuesta inflamatoria del huésped. La combinación de estos efectos puede contribuir al manejo de enfermedades como la caries, la gingivitis y la periodontitis (AU)


Periodontitis is a polymicrobial infection characterized by a destructive inflammatory process that results in the loss of teeth-supporting tissues. One of its main etiological agents, Porphyromonas gingivalis, is able to adhere and form a biofilm, contributing to the colonization of the oral cavity. It also synthesizes proteases that can degrade tissue and plasma proteins and contribute to the invasion of periodontal tissues. The usual procedures to prevent the progression of periodontal disease do not always achieve the expected clinical outcome. however, several studies indicate that cranberry polyphenols, namely proanthocyanidins (PACs), may inhibit the formation of dental plaque, the production of acid and proteolytic enzymes derived from different periodontal pathogens, as well as the host inflammatory response. The combination of these effects may contribute to the management of diseases such as caries, gingivitis and periodontitis (AU)


Assuntos
Humanos , Periodontite/prevenção & controle , Periodontite/terapia , Gengivite/prevenção & controle , Gengivite/terapia , Proantocianidinas/uso terapêutico , Vaccinium macrocarpon , Polifenóis/uso terapêutico , Doenças Periodontais/epidemiologia , Doenças Periodontais/prevenção & controle , Placa Dentária/tratamento farmacológico , Cárie Dentária/prevenção & controle
14.
Cient. dent. (Ed. impr.) ; 14(3): 207-212, sept.-dic. 2017. graf, ilus
Artigo em Espanhol | IBECS | ID: ibc-170391

RESUMO

Objetivo: En este estudio se realiza un seguimiento de implantes inmediatos con carga inmediata en alveolos afectados por periodontitis activa, con el fin de determinar la supervivencia de los mismos, la pérdida ósea y otras variables que puedan suponer el fracaso del tratamiento tanto quirúrgico como protésico. Material y métodos: Fueron seleccionados pacientes a los que se les colocaron implantes inmediatos post-extracción con carga inmediata en zonas afectadas por periodontitis durante 9 años (desde diciembre de 2006 hasta enero 2015). Se recolectó de forma retrospectiva información relativa a los datos demográficos, datos relativos al implante y datos relativos a la evolución del implante a lo largo del tiempo de seguimiento (estabilidad de los tejidos blandos, duros y prótesis). Se calculó la pérdida ósea marginal por implante y la supervivencia de los implantes y prótesis. Fue calculada también por implante la distancia entre el implante estudiado y su implante o diente adyacente y las repercusiones que tuvo esta distancia en el comportamiento del tejido blando peri-implantario y la formación de papila. Resultados: Fueron reclutados 25 pacientes en los que se insertaron 39 implantes post-extracción inmediata con carga inmediata en zonas infectadas por periodontitis. El tiempo medio de seguimiento fue de 6 años (rango 1 a 7 años). únicamente 3 de los implantes incluidos en el estudio no cumplieron con los criterios establecidos para el éxito implantológico y la supervivencia de los implantes fue del 100%. La media de pérdida ósea marginal fue de 1,50 mm (rango 0,61-5,01 mm). No se registró ningún fracaso de prótesis en los ca-sos estudiados aunque si un 6% de incidencias protésicas (aflojamiento de tornillos y fracturas de porcelana). Se encontró una correlación estadísticamente significativa entre la distancia al implante-diente adyacente y la estabilidad del tejido blando tras la cirugía (p=0,038). La media de la distancia entre el implante estudiado y el implante o diente adyacente cuando el tejido blando se mantuvo estable tras el tratamiento fue de 3,10 mm ±1,67 y cuando no se mantuvo estable fue de 2,09 mm ±1,95. La distancia media al diente-implante adyacente cuando se formó papila fue de 2,96 mm ±1,95 mm. Conclusiones: La carga inmediata de implantes post-extracción inmediata en implantes afectados por periodontitis (infección activa en el momento de la inserción del implante) no es un factor de riesgo para la supervivencia de los implantes según los datos obtenidos por este estudio (AU)


Objective: In this study is a follow-up of immediate implants with immediate loading in a post-extraction sockets affected by acute infection was made, in order to determine the survival of the implants, bone loss and survival of the implants and prosthesis. Material and Methods: patients who have implants immediate post-extraction with immediate loading in areas affected by periodontitis during 9 years (from December 2006 until January 2015) were selected. Retrospectively collected information on demographic data, data relating to the implant and data relating to the evolution of the implant over time of follow-up (soft tissue stability, hard and prosthesis). We calculated the marginal bone loss by implant and the survival of the implants and prostheses. The inter-implant distance was calculated by the distance between the implant and implant or adjacent tooth and the repercussions of this distance on the behavior of the peri-implant soft tissue and the papilla formation. Results: Finally 25 patients and 39 implants were included in the study. The mean follow-up time was 6 years (range 1 to 7 years). Only 3 of the implants included in the study did not meet the criteria for implantological success and the survival of the implants and prosthesis was 100%. The mean marginal bone loss was 1.50 mm (range 0.61-5.01 mm). In a 6% of the prosthesis mechanical complications were observed (loosening of screws and porcelain fractures). A statistically significant correlation was found between the distance to the adjacent tooth-implant and the stability of the soft tissue after surgery (p=0.038). The average distance between the implant and the implant or adjacent (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Extração Dentária/métodos , Implantação Dentária/métodos , Implantação Dentária/tendências , Alvéolo Dental , Alvéolo Dental/diagnóstico por imagem , Periodontite/diagnóstico por imagem , Periodontite/terapia , Implantes Dentários , Estudos de Coortes , Estudos Retrospectivos , Infecções/complicações , Infecções/tratamento farmacológico
15.
Med. oral patol. oral cir. bucal (Internet) ; 22(6): e708-e715, nov. 2017. graf, tab
Artigo em Inglês | IBECS | ID: ibc-168746

RESUMO

Background: Obesity is a very prevalent chronic disease worldwide and has been suggested to increase susceptibility of periodontitis. The aim of this paper was to provide a systematic review of the association between obesity and periodontal disease, and to determine the possible mechanisms underlying in this relationship. Material and Methods: A literature search was carried out in the databases PubMed-Medline and Embase. Controlled clinical trials and observational studies identifying periodontal and body composition parameters were selected. Each article was subjected to data extraction and quality assessment. Results: A total of 284 articles were identified, of which 64 were preselected and 28 were finally included in the review. All the studies described an association between obesity and periodontal disease, except two articles that reported no such association. Obesity is characterized by a chronic subclinical inflammation that could exacerbate other chronic inflammatory disorders like as periodontitis. Conclusions: The association between obesity and periodontitis was consistent with a compelling pattern of increased risk of periodontitis in overweight or obese individuals. Although the underlying pathophysiological mechanism remains unclear, it has been pointed out that the development of insulin resistance as a consequence of a chronic inflammatory state and oxidative stress could be implicated in the association between obesity and periodontitis. Further prospective longitudinal studies are needed to define the magnitude of this association and to elucidate the causal biological mechanisms (AU)


No disponible


Assuntos
Humanos , Doenças Periodontais/epidemiologia , Obesidade/complicações , Periodontite/epidemiologia , Estudos Epidemiológicos , Doenças Periodontais/diagnóstico , Bibliometria , Estudos Prospectivos , Estudos Longitudinais
16.
Arch. med. deporte ; 34(181): 267-273, sept.-oct. 2017. graf, tab, illus
Artigo em Inglês | IBECS | ID: ibc-170316

RESUMO

Until the moment, no study explored conjunctively the physical activity relation, using the inflammatory biomarkers, with the periodontitis. This way, the objective of this experiment was to evaluate the muscular tissue behavior of rats submitted to physical exercise in aquatic environment with experimental disease. Twenty-four male Wistar rats were divided in 4 groups: 1) control and sedentary (CS); 2) control and active (CA); 3) with the periodontal disease and sedentary (PDS); with the periodontal disease and active (PDA). On the group that the periodontitis was induced, it was for ligature and the groups with active swimming activity have practiced it for 4 weeks. At the end of 30 days the animals were euthanized and a portion of the gingival tissue and the soleus muscle were removed and underwent analysis by ELISA and morphological and morphometrical analysis of the muscle. Data drawn from the analysis was analyzed through ANOVA and Tukey. Results have shown that there is a higher expression of TNF-α in the gingival tissue and on the muscular tissue of the rats that underwent the induced periodontitis independently of the physical activity (PDS and PDA), as a meaningful decrease on the conjunctive tissue on the groups with induced periodontitis, that have or have not undergone active swimming activity which could suggest a predisposition to muscular injury or difficulty of muscular recovering on these groups. Therefore, it was possible to highlight a correlation between the periodontal disease and the muscle morphological changes, and, moreover, the physical swimming activity promoting an acceleration of the regeneration of the muscle tissue


Hasta este momento, ningún estudio ha explorado conjuntamente la relación de la actividad física con la periodontitis utilizando biomarcadores de inflamación. Siendo así, el objetivo de este estudio fue evaluar el comportamiento del tejido muscular de ratas con periodontitis experimental al realizar ejercicio físico en medio acuático. Veinticuatro ratas Wistar machos fueron divididas en cuatro grupos: 1) control y sedentario (CS); 2) control y ejercicio (CA); 3) con enfermedad periodontal y sedentario (PDS); 4) con enfermedad periodontal y ejercicio (PDA). En los grupos con periodontitis, la enfermedad periodontal fue inducida por ligadura y los grupos con ejercicio realizaron natación durante cuatro semanas. A los treinta días, los animales fueron sacrificados y una parte del tejido de las encías y del músculo soleo se resecaron y utilizaron para análisis con ELISA y para análisis morfológicos y morfométricos. Los datos obtenidos fueron analizados y evaluados a través de los tests ANOVA y TUKEY. Los datos mostraron una mayor expresión de TNF-α tanto en el tejido de las encías como en el tejido muscular de los ratones sometidos a periodontitis inducida independiente del ejercicio físico (PDS y PDA). Se percibió también una disminución significativa en el tejido conjuntivo en los grupos con periodontitis inducida sometidos o no al ejercicio de natación, lo que podría sugerir una predisposición a lesión muscular o una dificultad en la reparación de las lesiones musculares de esos grupos. Por lo tanto, fue posible destacar una correlación entre la enfermedad periodontal y los cambios morfológicos musculares y, además, que la actividad física de natación favoreció una aceleración de la regeneración del tejido muscular


Assuntos
Ratos , Periodontite/fisiopatologia , Músculo Esquelético/fisiologia , Exercício Físico/fisiologia , Modelos Animais de Doenças , Natação/fisiologia , Fator de Necrose Tumoral alfa/análise , Regeneração/fisiologia
17.
Med. clín (Ed. impr.) ; 149(5): 211-216, sept. 2017. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-165987

RESUMO

Antecedentes y objetivo: La relación entre la enfermedad cardiovascular aterotrombótica (ECVA) y las infecciones dentales, entre ellas la caries y las periodontitis apicales crónicas (PAC), ha sido poco estudiada y no está bien definida. Método: Se ha realizado una búsqueda sistemática en las bases de datos PubMed y Medline desde 1989 hasta 2016. Resultados: Se observó una relación con la ECVA en 10 de 10 estudios que abordaron el grado de higiene oral, en 14 de 17 que incluyeron la pérdida de dientes, en 6 de 12 que analizaron la caries y en 11 de 15 que incluyeron la PAC. Conclusiones: Se puede concluir que existe una asociación entre la PAC y la ECVA. Los pacientes con ECVA presentan un peor estado de higiene oral y menor número de dientes (AU)


Background and objective: The relationship between atherothrombotic cardiovascular disease (ATCD) and localised infections in teeth, including caries and chronic apical periodontitis (CAP) has not been studied much and is not well defined. Method: A systematic search was performed using the scientific databases PubMed and Medline from 1989 to 2016. Results: A significant relationship was observed with ATCD in 10 out of 10 studies addressing the degree of oral hygiene, in 14 of 17 that included loss of teeth, in 6 of 12 that analysed caries and in 11 of 15 that included CAP. However, there was a huge methodological heterogeneity. Conclusions: It can be concluded that there is an association between CAP and ATCD. Patients with ATCD present a worse oral hygiene status and fewer teeth (AU)


Assuntos
Humanos , Doenças Cardiovasculares/complicações , Doenças da Boca/complicações , Fatores de Risco , Embolia de Colesterol/complicações , Periodontite/complicações , Cárie Dentária/complicações
18.
Med. oral patol. oral cir. bucal (Internet) ; 22(5): e595-e600, sept. 2017. tab
Artigo em Inglês | IBECS | ID: ibc-166654

RESUMO

Background: The aim of this study was to determine whether saliva interleukin-6 (IL-6) levels are elevated in patients with rheumatoid arthritis versus a control group and examine the possible relationship between the oral condition and the risk of RA. Material and Methods: In 30 patients with RA and 30 healthy controls, different periodontal indices were recorded; sialometric measurements were taken to determine resting whole saliva, stimulated whole saliva and stimulated parotid saliva flow; and the saliva IL-6 levels were measured. Logistic regression analysis was performed, with the presence or absence of RA as dependent variable. Results: The patients with RA had a greater presence of bacterial plaque, a greater periodontal pocket depth, a larger percentage of medium-sized pockets, and greater periodontal attachment loss compared with the controls. Likewise, a decrease in resting and stimulated saliva flow was observed, together with an increase in saliva IL-6 levels. Logistic regression analysis reported that the plaque index is the principal differentiating factor of patients with RA. Stimulated parotid saliva flow was also significantly correlated to the presence of RA. Conclusions: The patients with RA showed a greater tendency to develop periodontal disease than the controls, with lower salivary flow and higher levels of IL-6 in saliva (AU)


No disponible


Assuntos
Humanos , Periodontite/epidemiologia , Interleucina-6/isolamento & purificação , Saliva/citologia , Artrite Reumatoide/fisiopatologia , Índice Periodontal , Biomarcadores/análise , Estudos Transversais , Placa Dentária/epidemiologia , Estudos Prospectivos , Estudos de Casos e Controles
19.
Cient. dent. (Ed. impr.) ; 14(2): 149-160, mayo-ago. 2017. ilus, graf, tab
Artigo em Espanhol | IBECS | ID: ibc-165680

RESUMO

Objetivo: El objetivo del presente artículo fue describir un caso clínico sobre regeneración periodontal y determinar, a propósito del mismo, la eficacia y la predictibilidad de las diferentes técnicas regenerativas en el tratamiento de defectos intraóseos causados por la periodontitis. Caso clínico: Se presenta el caso de un paciente varón de 65 años con periodontitis crónica avanzada localizada en el incisivo central superior derecho donde se planificó, en la fase de reevaluación, cirugía de regeneración debido a un defecto intraóseo visible radiográficamente, que se correspondía con una profundidad de sondaje de 11 mm. La lesión, que afectaba a la pared vestibular, distal y palatina, fue tratada con una combinación de xenoinjerto óseo (IOs), membrana de colágeno reabsorbible (RTG) y proteínas derivadas de la matriz del esmalte (PMEs), obteniendo como resultado una reducción en la profundidad de sondaje de hasta 7 mm después de nueve meses. Conclusión: La regeneración periodontal ha demostrado ser eficaz para el tratamiento de defectos intraóseos que comprometen la supervivencia del diente, ayudando al propio paciente a mantener una correcta salud y función oral (AU)


Aim: The aim of the present article was to describe a clinical case on periodontal regeneration and to assess the efficacy and predictability of different regenerative techniques for the treatment of intrabony defects caused by periodontitis. Case report: It presents the case of a 65- year-old male patient with localized severe chronic periodontitis where, after receiving basic periodontal treatment, regeneration surgery in tooth #11 was planned due to a radiographically visible intraosseous defect, corresponding to a pocket depth of 11 mm. The lesion, affecting the buccal, distal and palatal walls, was treated with a combination of bone xenograft (BGs), resorbable collagen membrane (GTR) and enamel matrix proteins (EMPs), resulting in a reduction in pocket depth up to 7 mm after nine months. Conclusion: Periodontal regeneration has been shown to be effective for the treatment of an intrabony defect that compromises tooth survival by helping the patient to maintain proper oral health and function (AU)


Assuntos
Humanos , Masculino , Idoso , Periodontite/cirurgia , Regeneração Tecidual Guiada Periodontal/métodos , Proteínas do Esmalte Dentário/uso terapêutico , Tempo , Transplante Ósseo/métodos , Higiene Bucal
20.
Med. oral patol. oral cir. bucal (Internet) ; 22(4): e425-e431, jul. 2017. tab
Artigo em Inglês | IBECS | ID: ibc-164942

RESUMO

Background: The validity of the surveys on self-reported smoking status is often questioned because smokers underestimate cigarette use and deny the habit. It has been suggested that self-report should be accompanied by cotinine test. This report evaluates the usefulness of serum cotinine test to assess the association between smoking and periodontal status in a study with a large sample population to be used in studies with other serum markers in epidemiologic and periodontal medicine researches. Material and Methods: 578 patients who were part of a multicenter study on blood biomarkers were evaluated about smoking and its relation to periodontal disease. Severity of periodontal disease was determinate using clinical attachment loss (CAL). Smoking was assessed by a questionnaire and a blood sample drawn for serum cotinine determination. Results: The optimal cut-off point for serum cotinine was 10 ng/ml. Serum cotinine showed greater association with severity of CAL than self-report for mild-moderate CAL [OR 2.03 (CI95% 1.16-3.53) vs. OR 1.08 (CI95% 0.62-1.87) ] advanced periodontitis [OR 2.36 (CI95% 1.30- 4.31) vs. OR 2.06 (CI95% 0.97-4.38) ] and extension of CAL > 3 mm [ OR 1.78 (CI95% 1.16-1.71) vs. 1.37 (CI95% 0.89-2.11)]. When the two tests were evaluated together were not shown to be better than serum cotinine test. Conclusions: Self-reported smoking and serum cotinine test ≥ 10ng/ml are accurate ,complementary and more reliable methods to assess the patient’s smoking status and could be used in studies evaluating serum samples in large population and multicenter studies. Clinical Relevance: The serum cotinine level is more reliable to make associations with the patient’s periodontal status than self-report questionnaire and could be used in multicenter and periodontal medicine studies (AU)


No disponible


Assuntos
Humanos , Fumar/efeitos adversos , Tabagismo/epidemiologia , Doenças Periodontais/epidemiologia , Cotinina/farmacocinética , Biomarcadores/análise , Periodontite/etiologia
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