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1.
Med. paliat ; 26(3): 257-258, jul.-sept. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-190251

RESUMO

Los pacientes con enfermedades terminales presentan frecuentes y diversos problemas de la piel debido a sus enfermedades de base y complicaciones de su situación: encamamiento, inmovilidad, malnutrición, incontinencia, etc. Estas lesiones ocasionan importante sufrimiento por el dolor, prurito, incomodidad, alteración de la imagen corporal y falta de intimidad. Por lo tanto, su abordaje eficaz por los médicos de cuidados paliativos es prioritario. En algún caso es posible conseguir un tratamiento causal efectivo en el corto periodo de tiempo disponible como demuestra el paciente descrito


Patients with terminal disease frecuently present various skin problems due to their underlying disease and complications of their clinical situation: bed-ridden, immobility, malnutrition, incontinence, etc. These lesions commonly produce significant suffering because of pain, itching, discomfort, body image distortion and lack of intimacy. Thus, an effective management of these by palliative care is prioritary. Occasionally, a specific treatment efficacious in the short time avalilable is possible as the present case shows


Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Dermatopatias/tratamento farmacológico , Cuidados Paliativos , Dermatite das Fraldas/complicações , Dermatopatias/diagnóstico , Glossite/complicações , Caquexia/complicações , Dermatite das Fraldas/tratamento farmacológico , Administração Tópica , Acrodermatite/complicações
5.
Med. oral patol. oral cir. bucal (Internet) ; 16(6): 711-715, sept. 2011. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-93077

RESUMO

Objectives: To explore the correlation between the severity of radiotherapy-induced glossitis (RTG) and endothelialcell injury in local tissues in a rat model.Study Design: The RTG animal model was designed and used by our team. The Oral mucositis index(OMI) wasdocumented daily. Immunohistochemistry (IHC) Staining of CD34 was utilized to identify endothelial cells in theRTG tissues. Apoptosis of endothelial cells in local lesions due to RTG was detected by the TUNEL assay. Thedynamic relationship between the OMI and apoptotic endothelial cells was statistically analyzed by time.Results and Conclusions: The injury and apoptosis of endothelial cells were observed 3 day post-irradiation. Thevascular lumens of the post-irradiation tongue lesions were irregular; thrombosis formation in the center of thelumens, unsmooth lumen walls and vasodilated vessels were observed. Also, endothelial cells detached from thebasal membrane and were found in the lumens. The percentages (%) of apoptotic endothelial cells were 78.3±0.31(5 day); 89.3±0.83 (8 day); 83.5±0.41 (14 day); 69.3±0.57 (21 day); and 47.3±0.59 (28 day). The OMI was correlatedwith the percentage of apoptotic endothelial cells (R0.034). Summary, endothelial cell injury was correlatedwith the pathogenic condition of RTG (AU)


No disponible


Assuntos
Animais , Ratos , Glossite/etiologia , Lesões por Radiação/diagnóstico , /normas , Estomatite/etiologia , Células Endoteliais
6.
Med. oral patol. oral cir. bucal (Internet) ; 16(3): 348-353, mayo 2011. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-93011

RESUMO

Objectives: To improve the existing animal models (mice, rats, and hamsters) for radiotherapy-induced oral mucositis(RTOM), thereby establishing a radiotherapy-induced glossitis (RTG) Sprague-Dawley (SD) rat model.Study Design: A lead device was designed to limit radiation exposure to a 1×1 cm2 area of a rat’s dorsal anteriortongue with a single 30Gy of X-ray radiation. The general conditions of the irradiated rats, such as body-weightand behavior, were observed. The oral mucositis index (OMI) of the RTG rats were measured daily. Histologicalchanges of the irradiated tongue tissues were assayed by H&E staining.Results and Conclusion: No significant changes were clinically observed 3 to 4 days after irradiation. At 5 to 6 day,punctuation and confluenced redness of the mucosa were observed. The small blood vessels became more extensive,engorged, thin vessel walls. More infiltrating cells were observable, necrosis and exfoliation of the squamouscells appeared, and the formation of an ulcerative lesion could be observed. Seven to 15 days, the exfoliated epitheliallayer was observed to have formed an ulcerative lesion, then aggravated ulcerative lesions consisting ofpseudomembranous filament exudates could be observed. The structure of the epithelium had become completelydisintegrated, forming deep, microscopic ulcerative lesions. Twenty-one days, the periphery of the ulcer wasobserved to have begun to heal, and granulation tissue could be observed at the bottom of the ulceration. At 35days after irradiation, the epithelial structure presented again, but the epithelium was very thin. An RTG animalmodel was successfully established in SD rats, which provides a new research platform for the study of RTOMpathogenesis (AU)


No disponible


Assuntos
Animais , Ratos , Glossite/fisiopatologia , Radioterapia/efeitos adversos , Estomatite/fisiopatologia , Lesões Experimentais por Radiação/fisiopatologia , Úlceras Orais/fisiopatologia , Modelos Animais
8.
Allergol. immunopatol ; 34(4): 171-173, jul. 2006. ilus
Artigo em Inglês | IBECS | ID: ibc-049231

RESUMO

Background: Approximately 150 species of Lepidoptera have been described as causing damage to human skin. One of these species is the pine processionary caterpillar, which is responsible for dermatitis, contact urticaria, ocular lesions and rarely respiratory signs and anaphylactic reactions through IgE-mediated or non-IgE-mediated mechanisms. We report a pediatric case of severe orofacial edema mimicking an allergic reaction after ingestion of a pine processionary caterpillar; urgent airway intubation was required. Case report: A 15-month-old boy was sleeping under a pine tree when his mother noted a pine caterpillar on his tongue. Because of rapidly developing facial swelling and respiratory distress, the infant was first taken to a local hospital where he received intravenous dexamethasone and pheniramine hydrogen maleate. On arrival at our emergency department, diffuse swelling and edema involving the tongue, perioral, nasal and perimandibular regions, and neck was noted, requiring urgent orotracheal intubation. There were no findings of anaphylaxis. The results of skin prick tests and specific IgE to common aero- and food allergens were negative. A skin prick test with extract of pine caterpillar was also negative. Prednisolone and pheniramine hydrogen maleate were administered for 7 days. The child gradually improved and was successfully extubated 4 days later. Conclusion: Although oral contact with a pine processionary caterpillar in the form of ingestion is rare, it may cause significant local reaction and airway compromise mimicking an allergic event. In this situation, early intubation to maintain airway patency is a life-saving measure


Antecedentes: aproximadamente se han descrito 150 especies de lepidopteros causantes de lesiones cutáneas. Uno de estos es la oruga de la procesionaria del pino que es responsable de dermatitis, urticaria de contacto, lesiones oculares y, raramente, síntomas respiratorios y reacciones anafilácticas por mecanismos mediadas o no por IgE. Presentamos un caso pediátrico de edema orofaríngeo grave con el aspecto clínico de una reacción alérgica, que se produjo tras la ingestión de una oruga de procesionaria del pino, siendo necesaria la intubación urgente de vías aéreas. Caso clínico: Cuando un lactante de 15 meses de edad dormía bajo un pino, su madre vio que tenía una oruga en la lengua. Se produjo uns rápida hinchazón facial y distres respiratorio, lo que requirió tratamiento endovenoso urgente en el hospital local, con dexametasona, feniramina y maleato iónico. A llegar al servicio de urgencias, se había desarrollado una hinchazón difusa y edema lingual, perioral, nasal, perimandibular y del cuello, por lo que se le practicó una intubación oro-traqueal. No hubo signos de reacción anafiláctica. El tratamiento con prednisolona, feniramina y maleato prosiguió durante siete días, con mejoría progresiva, pudiendo extubarse cuatro días más tarde. Las pruebas cutáneas y la IgE específica frente a neumoalergenos y alimentos comunes fueron negativas e igual la prueba con extracto de oruga de la procesionaria del pino. Conclusión: aunque el contacto oral con la oruga de la procesionaria del pino por ingestión es un raro incidente, puede causar una importante reacción local y grave afectación respiratoria semejantes a una reacción alérgica La intubación urgente para mantener la permeabilidad de las vías aéreas y las medidas salvadoras oportunas, son condición indispensable


Assuntos
Lactente , Animais , Humanos , Obstrução das Vias Respiratórias/etiologia , Edema/etiologia , Glossite/etiologia , Hipersensibilidade Imediata/diagnóstico , Mordeduras e Picadas de Insetos/complicações , Proteínas de Insetos/efeitos adversos , Mariposas , Língua/lesões , Urticária/etiologia , Obstrução das Vias Respiratórias/diagnóstico , Angioedema/diagnóstico , Dexametasona/uso terapêutico , Diagnóstico Diferencial , Edema/diagnóstico , Glossite/diagnóstico , Intubação Intratraqueal , Feniramina/uso terapêutico , Urticária/diagnóstico
9.
Med. oral patol. oral cir. bucal (Internet) ; 10(2): 123-127, mar.-abr. 2005. ilus
Artigo em Espanhol | IBECS | ID: ibc-038633

RESUMO

La glositis romboidal media (GRM) es una alteración benigna, poco frecuente, que afecta ligeramente más a los varones. Suele localizarse en la línea media del dorso de la lengua por delante de la “V” lingual, en forma de área rojiza, romboidal, plana como una mácula o a veces exofítica, mamelonada, que puede sobresalir de 2 a 5 mm, en la que no se observan papilas filiformes.Se presenta el caso clínico de un varón de 61 años de edad que consulta por presentar una lesión exofítica asintomática en dorso de lengua, situada a nivel paramedial izquierdo. El estudio histopatológico es compatible con glositis romboidal. Se debe realizar el diagnóstico diferencial con otras lesiones exofíticas frecuentes en esta localización como: hemangioma o lesión vascular, granuloma piogénico, amiloidosis, tumor de células granulares y carcinoma de células escamosas, analizando tanto los aspectos clínicos como histopatológicos de cada una de ellas. A través de este caso clínico comprobamos que la GRM puede tener una localización paramedial, que denominamos atípica


Median rhomboid glossitis (MRG) is an uncommon benign abnormality of the tongue, most frequently affecting men. It is typically located around the midline of the dorsum of the tongue, anterior to the lingual “V”, appearing as a reddish, rhomboid area, depapillated, flat maculate or mamillated and raised by 2 - 5 mm. This paper reports a case of rhomboid glossitis in a 61-year-old man who consulted for a painless raised lesion on the dorsum of the tongue, in left paramedial (not medial) location. Histopathological findings were compatible with rhomboid glossitis. Other diagnoses considered but ruled out on the basis of the clinical and histopathological findings were haemangioma, pyogenic granuloma, amyloidosis, granular cell tumour, and squamous cell carcinoma. This case confirms that rhomboid glossitis may occur in paramedial locations


Assuntos
Masculino , Humanos , Doenças da Língua/patologia , Glossite/patologia , Glossite/diagnóstico , Glossite/etiologia , Candida albicans , Diagnóstico Diferencial , Antifúngicos/administração & dosagem , Hemangioma/patologia , Granuloma Piogênico/patologia , Amiloidose/patologia , Tumor de Células Granulares/patologia , Biópsia por Agulha , Neoplasias de Células Escamosas/patologia , Neoplasias da Língua/patologia
10.
Actas dermo-sifiliogr. (Ed. impr.) ; 96(3): 175-178, abr. 2005. ilus
Artigo em Espanhol | IBECS | ID: ibc-037601

RESUMO

El glucagonoma es un raro tumor pancreático que habitualmente se asocia a un síndrome que incluye diabetes, anemia, pérdida de peso y lesiones cutáneas en forma de eritema necrolítico migratorio. Se presenta el caso de una paciente con un glucagonoma maligno tratado con cirugía y octreótida que se manifestó con lesiones cutáneas. Se revisa la fisiopatología, las otras causas de eritema necrolítico, el diagnóstico y diagnóstico diferencial y el tratamiento


Glucagonoma is a rare pancreatic tumor that isusually associated with a syndrome that includes diabetes, anemia, weight loss and skin lesions in the form of necrolyticmigratory erythema. We present the case of a patient with malignant glucagonoma treated with surgery and octreotide, which manifested with skin lesions. The discussion will review the physiopathology, other causes of necrolytic erythema, diagnosis and differential diagnosis and treatment


Assuntos
Feminino , Adulto , Humanos , Glucagonoma/complicações , Glucagonoma/diagnóstico , Glucagonoma/cirurgia , Eritema/complicações , Eritema/diagnóstico , Eritema/terapia , Glucagon/uso terapêutico , Biópsia , Hiperpigmentação/complicações , Eritema/fisiopatologia , Neoplasia Endócrina Múltipla/complicações , Neoplasia Endócrina Múltipla/diagnóstico , Nistatina/uso terapêutico , Queilite/complicações , Queilite/diagnóstico , Glossite/complicações , Glossite/diagnóstico , Prognóstico
11.
Fontilles, Rev. leprol ; 22(3): 231-240, sept. 2001.
Artigo em Espanhol | IBECS | ID: ibc-26738

RESUMO

La lepra como enfermedad infecciosa producida por el Mycobacterium leprae, asienta sobre la reacción enfermo-sano, y aunque se considera el hombre enfermo como reservorio exclusivo, en los últimos años se ha encontrado de forma natural en algunos primates y en el armadillo. Existe una clara preferencia en la lepra por la afectación de los nervios periféricos, sobre todo los correspondientes a las zonas distal de las extremidades. Estas alteraciones nerviosas son frecuentes en la lepra tuberculoide (LT) a nivel del V y VII par craneal provocando anestesia, neuralgia y parálisis de distintos sectores bucales. En la lepra lepromatosa (LL) las alteraciones nerviosas son menores, pero en cambio, son más frecuentes las lesiones en la mucosa oral. Presentamos un paciente con lepra lepromatosa (LL) en actividad, con clínica e histopatología oral típica de la enfermedad. Se demostró la presencia de bacilos en lengua. Se le realizó una serie radiográfica completa para rehabilitar su cavidad oral. Observamos recesión gingival en el sector anterior del maxilar superior e inferior, con pérdida de la vitalidad dentaria en varias piezas. Ante la necesidad de realizar tratamientos endodóncicos por las distintas patologías pulpares, nos planteamos previamente, el intentar aislar bacilos en mucosa gingival y pulpa dentaria, lo cual a diferencia de la mucosa lingual fue negativo (AU)


Assuntos
Masculino , Pessoa de Meia-Idade , Humanos , Glossite/etiologia , Hanseníase Virchowiana/complicações , Doenças da Polpa Dentária/etiologia
12.
Rev. esp. geriatr. gerontol. (Ed. impr.) ; 36(supl.1): 25-28, mar. 2001.
Artigo em Espanhol | IBECS | ID: ibc-150865

RESUMO

El tabaco constituye un importante factor de aceleración del envejecimiento cutáneo, determinando el hábito tabáquico efectos sobre el organismo, tales como mayor sequedad de la piel y propensión más temprana a la aparición de arrugas, pigmentación amarilla de la punta de los dedos y de las uñas, caída de cabello, hiperpigmentación de la mucosa oral, glositis tabáquica, carcinoma de lengua, carcinoma de labio, alteración del color normal de los dientes, gingivitis, halitosis, faringitis seca, disfonía («ronquera del fumador») y alteración en la percepción del olfato. Igualmente produce un retardo en el proceso normal de curación de las heridas, con mayor tiempo de cicatrización y aumento de las complicaciones. Aunque el tabaco no constituya un factor etiológico para el cáncer de piel, el deterioro que produce sobre ésta y concretamente en el sistema inmune, caso del melanoma, hacen que aquellos pacientes fumadores tengan peor pronóstico que los no fumadores. El envejecimiento, con pérdida de elasticidad y de mayor fragilidad cutánea, con un mayor riesgo de traumatismos y heridas, y con menor protección ante agresiones (sol o microorganismos), hace que la piel sea especialmente vulnerable a la acción del tabaco, condicionando una peor situación de la piel en los ancianos fumadores (AU)


Tobacco constitues an important factor in the aceleratin of skin aging. The use of tobacco gives different effects over the organism, for example: dry skin and earlier propension to the appearence of wrinkles, yellow pigmentation in the tipo of the fingers and nails, hair fall, hiperpigmentation of the oral mucose, glossitis of tobacco, cancer of tongue, cancer of lip, colour alteration of the teeth, gingivitis, halitosis, dry pharyngitis, dysphonia and sense of smell alteration. Tobacco produces also a delay in the normal process of cure of injuries, with more time of healing and increase of complications. Although tobacco doesn’t constitude an etiological factor for the skin cancer, the deterioration it makes over it and over the immunity (case of melanoma melanoma) makes smokers bad prognosis than no smokers. Aging with lost- elasticity and fragility of kin, with more risk of traumatism and injuries and less protection agains the aggressions (sun or microorganism) makes skin especially vulnerable to the tobacco action, giving worse skin situation in smoking elderly (AU)


Assuntos
Humanos , Masculino , Feminino , Idoso , Fumar/etnologia , Fumar/psicologia , Dermatopatias/classificação , Dermatopatias/metabolismo , Envelhecimento da Pele , Envelhecimento da Pele/fisiologia , Mucosa Bucal/anormalidades , Glossite/patologia , Fumar/prevenção & controle , Fumar/terapia , Dermatopatias/complicações , Dermatopatias/diagnóstico , Envelhecimento da Pele/etnologia , Envelhecimento da Pele/genética , Mucosa Bucal/patologia , Glossite/complicações
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