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3.
Med. oral patol. oral cir. bucal (Internet) ; 24(1): e84-e88, ene. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-180410

RESUMO

Background: Cancer of the oral cavity combined with oropharyngeal cancer is the sixth leading cause of death for cancer worldwide. Surgery remains the standard treatment for this disease in early clinical and locally advanced stages. Numerous studies have shown that laser management is useful for premalignant lesions in the oral cavity; however, there is no conclusive evidence that its use is appropriate in cancer of the oral cavity and that results are comparable with traditional surgery. The objective of this study is to determine cancer control after wide local resection with CO2 laser for oral malignant neoplasms. Material and Methods: Retrospective study in patients with tumors of the oral cavity who were considered for surgical resection with CO2 laser from January 2006-December 2015. Demographic data, treatment modalities, histopathological diagnosis and clinical stage variables were obtained. All resections were done with the use of the microspot. Patients with cancer of the tongue were not included because a specific protocol for these patients does exist in our institution. Results: There were twenty patients, 10 male and 10 female with a average age of 58 years (range: 20-92 years). Mean age was 53.5 years for females and 63 years for males. Twelve (60%) patients are alive and disease free and four (20%) were lost free of disease. Conclusions: CO2 laser is an acceptable surgical method for the management of small lesions in the oral cavity. We cannot rule out that small lesions of the oral cavity with positive neck could be managed in this manner, adding treatment to the neck, producing an adequate local regional control. However, this hypothesis requires additional studies


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Bucais/cirurgia , Terapia a Laser/métodos , Lasers de Gás , Neoplasias Bucais/epidemiologia , Resultado do Tratamento , Estudos Retrospectivos , Melanose/patologia , Melanoma/patologia
4.
Actas dermo-sifiliogr. (Ed. impr.) ; 108(9): e57-e62, nov. 2017.
Artigo em Espanhol | IBECS | ID: ibc-168144

RESUMO

El síndrome del nevus melanocítico congénito (SNMC) consiste en la proliferación anormal de melanocitos en la piel y el sistema nervioso central, y se debe a mutaciones de las células progenitoras durante el desarrollo embrionario. En muchas de estas células se han detectado mutaciones en el gen NRAS. Se exponen 5 casos de nevus melanocítico congénito gigante, 3 de ellos asociados al SNMC, en los que se ha estudiado dicha mutación. Hasta hace unos años la cirugía era el tratamiento de elección, sin embargo, sus resultados son insatisfactorios, con cirugías agresivas que no mejoran el aspecto estético y reducen mínimamente el riesgo de malignización. En el año 2013 se aprobó el trametinib en el uso del melanoma avanzado con mutaciones de NRAS. Dicho fármaco, que participa en la cascada intracelular de RAS-RAF-MEK-pERK-MAPK, podría ser útil en pacientes pediátricos con SNMC. El conocimiento más amplio de esta enfermedad permitirá crear nuevas estrategias (AU)


Congenital melanocytic nevus syndrome (CMNS) is the result of an abnormal proliferation of melanocytes in the skin and central nervous system caused by progenitor-cell mutations during embryonic development. Mutations in the NRAS gene have been detected in many of these cells. We present 5 cases of giant congenital melanocytic nevus, 3 of them associated with CMNS; NRAS gene mutation was studied in these 3 patients. Until a few years ago, surgery was the treatment of choice, but the results have proved unsatisfactory because aggressive interventions do not improve cosmetic appearance and only minimally reduce the risk of malignant change. In 2013, trametinib was approved for use in advanced melanoma associated with NRAS mutations. This drug, which acts on the intracellular RAS/RAF/MEK/pERK/MAPK cascade, could be useful in pediatric patients with CMNS. A better understanding of this disease will facilitate the development of new strategies (AU)


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Nevo Pigmentado/congênito , Melanose/genética , Síndromes Neurocutâneas/genética , Síndrome do Hamartoma Múltiplo/congênito , Mutação/genética , Marcadores Genéticos , Melanócitos
6.
Actas dermo-sifiliogr. (Ed. impr.) ; 108(4): 315-322, mayo 2017. tab, graf, ilus
Artigo em Espanhol | IBECS | ID: ibc-163112

RESUMO

Las exfoliaciones químicas (más conocidas como peelings químicos) son tratamientos utilizados frecuentemente en dermatología estética. En concreto el peeling con ácido tricloroacético se ha utilizado desde hace años y una de sus principales limitaciones clásicamente era sus efectos secundarios. Presentamos una revisión práctica de las características, mecanismos de acción, indicaciones y complicaciones de los peelings en general, tanto los superficiales como el peeling con ácido tricloroacético (AU)


Chemical peeling is a common treatment in cosmetic dermatology. A peel that has been used for many years is trichloroacetic acid. Its adverse effects have for a long time been a major limitation. We present a practical review of the characteristics, mechanisms of action, indications, and complications of superficial chemical peels and of peeling with trichloroacetic acid (AU)


Assuntos
Humanos , Rejuvenescimento , Ácido Tricloroacético/uso terapêutico , Abrasão Química/classificação , Melanose/tratamento farmacológico , Envelhecimento da Pele , Abrasão Química/métodos , Hidroxiácidos/uso terapêutico
10.
Actas dermo-sifiliogr. (Ed. impr.) ; 107(6): 454-464, jul.-ago. 2016. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-154340

RESUMO

La neurofibromatosis tipo 1 (NF1) es el síndrome neurocutáneo más frecuente y probablemente el mejor conocido por los dermatólogos. Aunque desde 1987 se sabe que el locus genético de la NF1 se localiza en el cromosoma 17, en la actualidad el diagnóstico de la NF1 sigue siendo fundamentalmente clínico. Los criterios diagnósticos del National Institute of Health están vigentes desde el año 1988 e incluyen 7 criterios diagnósticos, de los cuales tres se manifiestan en la piel: las manchas café con leche [MCCL], las efélides flexurales, y neurofibromas cutáneos. La edad de aparición de los distintos criterios diagnósticos es variable, y algunos pacientes los manifiestan tardíamente o incluso no los desarrollan nunca, por lo que el diagnóstico de certeza puede demorarse durante años. Las MCCL y las efélides aparecen en los primeros años de la vida y son muy sugerentes de la enfermedad, pero no son patognomónicas y resultan insuficientes para realizar el diagnóstico de certeza. Así, cuando los pacientes presentan exclusivamente MCCL y efélides es imprescindible considerar otros diagnósticos. Por el contrario, la existencia de múltiples neurofibromas cutáneos, o al menos un neurofibroma plexiforme, son muy específicos de la NF1. La identificación de las distintas formas de neurofibromas nos permite confirmar el diagnóstico de la enfermedad y hacer un seguimiento adecuado de los mismos (AU)


Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome and probably the one best known to dermatologists, who are generally the first physicians to suspect its diagnosis. Although the genetic locus of NF1 was identified on chromosome 17 in 1987, diagnosis of the disease is still mainly based on clinical observations and the diagnostic criteria of the National Institute of Health, dating from 1988. Cutaneous manifestations are particularly important because café-au-lait spots, freckling on flexural areas, and cutaneous neurofibromas comprise 3 of the 7 clinical diagnostic criteria. However, café-au-lait spots and freckling can also be present in other diseases. These manifestations are therefore not pathognomonic and are insufficient for definitive diagnosis in the early years of life. NF1 is a multisystemic disease associated with a predisposition to cancer. A multidisciplinary follow-up is necessary and dermatologists play an important role (AU)


Assuntos
Humanos , Neurofibromatose 1/diagnóstico , Manchas Café com Leite/diagnóstico , Melanose/diagnóstico , Neurofibroma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Síndrome LEOPARD/diagnóstico , Diagnóstico Diferencial , Piebaldismo/diagnóstico , Neurofibromina 1/análise , Síndromes Neurocutâneas/diagnóstico , Nevo/diagnóstico
12.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 42(4): 189-192, oct.-dic. 2015. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-143279

RESUMO

Los melanomas malignos de las mucosas son tumores raros. Se localizan con más frecuencia en la cavidad nasal, la cavidad oral, la conjuntiva ocular, la mucosa genital y el área perianal. La característica clínica más frecuente en estos melanomas es la presencia de una hiperpigmentación macular extensa e irregular plana, en ocasiones moteada, que se extiende durante años, antes de elevarse. El melanoma del tracto genital femenino es la segunda neoplasia primaria más frecuente de la vulva, representando un 3% de todos los melanomas diagnosticados en la mujer. El melanoma vaginal se origina en áreas de melanosis o de hiperplasia melanocítica atípica. La mayoría de los casos ocurre en mujeres caucásicas y alrededor de la 6.a década de la vida. El síntoma más común es el sangrado genital. El melanoma maligno de las mucosas tiene un comportamiento agresivo con una alta tasa de fracaso local y metástasis. La supervivencia a los 5 años es menor del 20%


Mucosal malignant melanomas are rare tumors. They are usually located in the nasal cavity, oral cavity, conjunctiva, genital mucosa, and the perianal area. The most common clinical feature of these melanomas is the presence of extensive and irregular, sometimes mottled, macular hyperpigmentation. These tumors are usually flat for years before becoming elevated. Melanoma of the female genital tract is the second most common primary neoplasm of the vulva, accounting for 3% of all melanomas diagnosed in women. Vaginal melanoma arises in areas of melanosis or atypical melanocytic hyperplasia. Most cases occur in Caucasian women around the sixth decade of life. The most common symptom is vaginal bleeding. Mucosal malignant melanoma has an aggressive course with a high rate of local failure and metástasis. Five-year survival is less than 20%


Assuntos
Idoso , Feminino , Humanos , Melanoma/patologia , Membrana Mucosa/patologia , Neoplasias Vaginais/patologia , Neoplasias Vulvares/patologia , Melanose/patologia
14.
18.
Artigo em Inglês | IBECS | ID: ibc-106084

RESUMO

Diagnosis of pigmented lesions of the oral cavity and perioral tissues is challenging. Even though epidemiology may be of some help in orientating the clinician and even though some lesions may confidently be diagnosed on clinical grounds alone, the definitive diagnosis usually requires histopathologic evaluation. Oral pigmentation can be physiological or pathological, and exogenous or endogenous. Color, location, distribution, and duration as well as drugs use, family history, and change in pattern are important for the differential diagnosis. Dark or black pigmented lesions can be focal, multifocal or diffuse macules, including entities such as racial pigmentation, melanotic macule, melanocytic nevus, blue nevus, smoker’s melanosis, oral melanoacanthoma, pigmentation by foreign bodies or induced by drugs, Peutz-Jeghers syndrome, Addison´s disease and oral melanoma. The aim of this review is to present the main oral black lesions contributing to better approach of the patients (AU)


No disponible


Assuntos
Humanos , Transtornos da Pigmentação/patologia , Mucosa Bucal/patologia , Melaninas/análise , Imuno-Histoquímica , Melanose/patologia
20.
Med. oral patol. oral cir. bucal (Internet) ; 16(5): 641-646, ago. 2011. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-93064

RESUMO

Objectives: To highlight the most characteristic histopathological findings of oral lichen planus and their correlationwith the clinical manifestations and forms.Study design: We performed a retrospective study of 50 biopsied and diagnosed cases of oral lichen planus obtainedover a period of 11 years, spanning from May 1998 to April 2009. We analyzed the age and sex of thepatient, type of lichen planus, location and different histopathological findings, comparing them with the clinicallesions.Results: Seventy eight percent of the patients are female and 22% are male, with an average age of 56.06 years forboth sexes. The most frequent clinical form is reticular, present in 78% of the cases, and the most common locationis the buccal mucosa, present in 70% of the patients. Hydropic degeneration of the basal layer and lymphocyticinfiltration in the subepithelial layer are observed in the entire sample. Signs of atypia were identified in 4% of thecases, but without dysplasic features. Other common histological findings were the presence of necrotic keratinocytes(92%), hyperplasia (54%), hyperkeratosis (66%), acanthosis (48%), and less frequently, serrated ridges (30%)and the presence plasma cells (26%) (AU)


Assuntos
Humanos , Líquen Plano Bucal/patologia , Queratinócitos/patologia , Ictiose/patologia , Linfócitos do Interstício Tumoral , Melanose/patologia
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