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1.
Allergol. immunopatol ; 48(1): 3-7, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186585

RESUMO

Background: Anaphylaxis is a sudden, severe, and potentially life-threatening allergic reaction, affecting a portion of allergic patients. Adrenaline is the first-line medication for anaphylaxis and available in many parts of the world as adrenaline autoinjectors (AAIs). Objective: Aim of this study was to determine attitudes and knowledge levels of patients/parents regarding the use of AAIs, frequency, and rate of appropriate AAI use and to give a standardized and better education by improving on mistakes during administration. Method: 190 patients aged 1-18 years who were prescribed AAIs for any reason between 2012 and 2017 in Hacettepe University Pediatric Allergy Unit. Demographic data were collected during face-to-face interview or by telephone. Parents completed a mini-survey regarding use, carriage, and storage of AAI. Results: Some 190 patients (64.7% male) aged 7.83 (4.99-12.08) years, median (inter-quartile), were included in the study. The indications for AAI prescription were food allergy (78.9%); venom allergy (14.2%); idiopathic anaphylaxis (3.7%); mastocytosis (2.1%); and drug allergy (1.0%). One-fourth of AAI-prescribed patients experienced anaphylaxis requiring the use of AAI within the past five years. However, only 30% of the patients dared to use AAI; only three-quarters of whom had managed to use it correctly. Conclusion: After prescription of AAI and initial training, patients and parents' concerns and fears should be taken into consideration and necessary support should be provided. At every opportunity and each clinical visit, not only should training sessions be repeated but also the patients and parents should be psychologically supported


No disponible


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Epinefrina/uso terapêutico , Autoadministração/métodos , Anafilaxia/tratamento farmacológico , Hipersensibilidade Alimentar/tratamento farmacológico , Asma , Rinite , Dermatite Atópica
2.
Allergol. immunopatol ; 48(1): 26-33, ene.-feb. 2020. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-186588

RESUMO

Introduction and Objectives: The production and consumption of oysters is increasing annually because it can provide essential nutrients and benefit for human health, leading to frequent occurrence of severe allergic reactions observed in sensitized individuals. The aim of the present study was to investigate the effects of acid and protease treatment on the conformation and IgE-binding capacity of recombinant Crassostrea gigas tropomyosin (Cra g 1). Results: Under acidic conditions, Cra g 1 did not undergo degradation, however, the changes obvious in the intensity of CD signal and ANS-binding fluorescence were observed, which was associated with a decrease in antibody reactivity. In simulated gastrointestinal fluid (SGF) and simulated intestinal fluid (SIF) digestion system, acid-treated Cra g 1 was relatively resistant to digestion, but the degradative patterns were very different. Moreover, owing to alterations of secondary structure and hydrophobic surface of the protein during digestive processing, antigenicity of acid-induced Cra g 1 reduced in SGF while it increased significantly in SIF. Conclusion: To our knowledge, this is the first study reporting that antigenicity of acid-treated oyster tropomyosin increased after SIF digestion. These results revealed that treatment with acid and pepsin, rather than trypsin, was an effective way of reducing IgE-binding capacity of tropomyosin from oyster


No disponible


Assuntos
Humanos , Imunoglobulina E/imunologia , Técnicas In Vitro/métodos , Alérgenos/química , Tropomiosina/química , Hipersensibilidade Alimentar/imunologia , Digestão , Alérgenos/imunologia , Tropomiosina/imunologia , Ostreidae/imunologia , Sistema Digestório/imunologia , Eletroforese/métodos , Análise Espectral/métodos , Ensaio de Imunoadsorção Enzimática
3.
Allergol. immunopatol ; 48(1): 48-55, ene.-feb. 2020. graf, tab
Artigo em Inglês | IBECS | ID: ibc-186591

RESUMO

Background: Several pro-inflammatory and anti-inflammatory mediators play a role in the immunopathogenesis of food allergy (FA). The aim of this study was to investigate the utility of serum biomarkers like interleukin (IL)-10, TNF-alfa, and IL-6 in the diagnosis and/or follow-up of FA. Methods: Sixty (25 females, 41.6%) newly diagnosed FA patients [IgE mediated (group-1, n = 37), non-IgE (group-2, n = 23)] with a median age of nine (1-33) months were enrolled. Twenty-four healthy children with a median age of eight (1-36) months constituted the control group (CG). In all the subjects, serum TNF-alfa, IL-6 and IL-10 levels were evaluated at the time of diagnosis and reassessed four weeks after therapeutic elimination diet (TED). Results: The mean white blood cell count and median absolute eosinophile count of the CG were significantly lower than group-1 (p values were 0.019 and 0.006, respectively). The mean absolute neutrophile count and the median IL-6 were significantly higher in group-1 when compared with group-2 (p values were 0.005 and 0.032, respectively. Median TNF-alfa and IL-6 levels were significantly higher in the pre-TED among all patients (p values were 0.005 and 0.018, respectively). In group-1, median TNF-α and IL-6 levels decreased significantly after TED (p values were 0.01 and 0.029, respectively). Conclusions: Our findings support the role of inflammation in the pathogenesis of FA. Serum TNF-alfa and IL-6 levels may be useful markers for follow-up in FA, especially among IgE-mediated FA patients. Evaluation of IL-10 results was not sufficient for an interpretation of clinical tolerance


No disponible


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Interleucina-10/sangue , Interleucina-6/sangue , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Imediata/diagnóstico , Fator de Necrose Tumoral alfa/sangue , Mucosa Intestinal/imunologia , Algoritmos , Alérgenos , Anafilaxia/imunologia , Biomarcadores , Fator de Necrose Tumoral alfa/imunologia , Fator de Necrose Tumoral alfa/análise
4.
Allergol. immunopatol ; 48(1): 67-72, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186594

RESUMO

Background: There is little understanding of the mechanisms by which food allergy (FA) develops into persistent disease, or by which symptoms it regresses. Food allergy is a major health problem in developed countries, where the prevalence reaches up to 6% in children and 3% in the adult population. Objective: Children with food allergy remission (FAR) and those without FAR below five years of age, were compared 7-10 years with respect to clinical data and expression of glycoprotein A repetitions predominant (GARP) on peripheral blood mononuclear cells. Methods: Forty children with FAR and 40 children without FAR at age 7-10, in whom FA was previously diagnosed at age below five years were evaluated. In this prospective study, demographic and clinical data were taken, patients were classified as atopic based on history and serum specific IgE (sIgE) for a specific allergen. Blood samples were obtained from all patients to assess expression of GARP. Results: We observed higher expression of GARP in children with FAR compared to children without FA (p = 0.005); optimal cut-off for GARP prediction of the remission was 20.1%. Children with FAR and food-specific IgE in serum had higher expression of GARP compared to children with low food specific IgE (< 0.35 kU/L). Keeping pets at home decreased, and presence of allergic rhinitis increased ORs for high expression of GARP (hGARP) in our patients. Conclusion: hGARP (>20.1%) is related with FAR in school children. Allergic rhinitis, and pets at home modify this effect of GARP. Children with allergic rhinitis have less chance of developing remission despite maintaining immune tolerance (hGARP); quite the opposite case with pets at home


No disponible


Assuntos
Humanos , Criança , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Imediata/imunologia , Imunoglobulina E/sangue , Fatores de Transcrição , Glicoproteínas/imunologia , Hipersensibilidade Alimentar/imunologia , Imunoglobulina E/imunologia , Leucócitos Mononucleares/imunologia , Rinite Alérgica , Hipersensibilidade Alimentar/sangue , Estudos Prospectivos , Modelos Logísticos , Glicoproteínas/metabolismo
5.
Allergol. immunopatol ; 48(1): 78-83, ene.-feb. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-186596

RESUMO

Background: Pollen-food syndrome (PFS) is an allergic reaction to fresh fruits, vegetables and/or nuts that can occur in patients who are allergic to pollen. The prevalence of PFS in children is not clearly known. Objective: The objective of this study was to determine the frequency and clinical features of PFS in pediatric patients with pollen-induced allergic rhinitis (AR). Method: This study was conducted in the pediatric allergy outpatient clinic of our hospital. Pollen-induced seasonal AR patients who were evaluated for any symptoms appearing after consuming any fresh fruits and vegetables. Results: Six hundred and seventy-two pollen-sensitized patients were included in this study. The symptoms related to PFS were reported in 22 (3.3%) patients. The median age of the patients was 12.3 years and 59% (n = 13) were female. Peach was the most common culprit (22%). There were isolated oropharyngeal symptoms in 20 (91%) patients and anaphylaxis in two (9%) patients with the suspected food. The multiple logistic regression analysis revealed that female gender, history of atopic dermatitis and allergic diseases in the family were the potential risk factors for PFS [Odds ratio 95% CI: 3.367 (1.344-8.435), 5.120 (1.935-13.550), 3.046 (1.239-7.492), respectively]. Conclusion: PFS can be seen in children who are followed up for pollen-induced AR. The symptoms of PFS are usually mild and transient. However, comprehensive evaluation of patients is important since serious systemic reactions such as anaphylaxis can also be observed


No disponible


Assuntos
Humanos , Feminino , Criança , Rinite Alérgica Sazonal/epidemiologia , Hipersensibilidade Alimentar/epidemiologia , Rinite Alérgica Sazonal/diagnóstico , Plantas/efeitos adversos , Frutas/efeitos adversos , Modelos Logísticos , Imunoterapia , Anafilaxia/epidemiologia
6.
Allergol. immunopatol ; 48(1): 95-104, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186599

RESUMO

Introduction: Food allergy is considered a public health problem for children. The modulation of the intestinal microbiota seems a promising strategy for the control of allergic reactions. Objective: To describe the effects of different forms of probiotics in pediatric food hypersensitivity treatment. Data source: We conducted a systematic review based on clinical trials published in the PubMed and Web of Science databases. The searches were carried out using the MeSH terms "Food Hypersensitivity", "Probiotics," "Lactobacillus", and "Bifidobacterium". Data synthesis: The final selection resulted in 18 clinical trials, which were predominantly samples of infants and pre-school children. The most-often used strain, either alone or in combination, was Lactobacillus rhamnosus GG; a placebo was mainly used in the control group. As for the vehicle, the most common forms were capsules and infant formulas, and the period of intervention ranged from four weeks to 24 months, with weekly or monthly visits to measure the outcomes. In these 18 trials, 46 analyses were performed with 27 different types of outcomes to evaluate the effects of probiotics (12 laboratory and 15 clinical). Twenty-seven of these analyses demonstrated the benefits of using these microorganisms. The SCORAD (atopic dermatitis index) and IgE levels and cytokines were the outcomes mostly evaluated. Conclusion: The use of probiotics is beneficial in promoting immunomodulation and reducing clinical symptoms. However, more methodologically based research is needed to clarify the effect from each type, dose, and time of using them for the establishment of definitive care protocols


No disponible


Assuntos
Humanos , Criança , Adolescente , Hipersensibilidade Alimentar/terapia , Probióticos/uso terapêutico , Microbioma Gastrointestinal/imunologia , Imunomodulação , Lactobacillus/imunologia , Dermatite Atópica/imunologia , Imunoglobulina E
7.
Allergol. immunopatol ; 47(6): 535-543, nov.-dic. 2019. tab, graf, ilus
Artigo em Inglês | IBECS | ID: ibc-186545

RESUMO

Introduction: Food allergies are inflammatory conditions mediated by Th2 and probably STAT-6 dependent immune responses. Objective and design: Here we investigated the role of Signal Transducer and Activator of Transcription 6 (STAT-6) in development of inflammation in peanut allergy. Methods: To induce food allergy, wild-type (WT) and mice deficient for STAT-6 (Stat6-/-) were sensitized with peanut proteins and challenged with peanut seeds. Results: WT animals lost weight and refused the peanut diet, in contrast to Stat6-/- mice, which had a better maintenance of body weight and more regular seeds' consumption. The augmented peanut-specific IgG, IgG1 and IgE in the allergic WT was abolished in Stat6-/- animals that also presented increased IgG2a. There was an overall reduction in the gut mediators in the absence of STAT-6, including those related to inflammatory and Th2 responses, in contrast to a rising counter regulatory and Th1 reaction in Stat-6-/- mice. These animals had IFN-γ and IL-10 similar to WT after the four-week challenge. Most interestingly, Stat-6-/- mice had no intestinal damage, in contrast to WT animals, which had inflammatory infiltrate, tissue destruction, epithelial exulceration, edema, congestion and loss of villous architecture in the small gut segments. Conclusions: STAT-6 plays an important role in the establishment of the Th2 inflammatory responses and intestinal damage in peanut allergy


No disponible


Assuntos
Animais , Fator de Transcrição STAT6/uso terapêutico , Células Th2/imunologia , Hipersensibilidade a Amendoim/imunologia , Hipersensibilidade a Amendoim/veterinária , Hipersensibilidade Alimentar/imunologia , Hidróxido de Alumínio/uso terapêutico , Eutanásia , Ensaio de Imunoadsorção Enzimática
8.
Allergol. immunopatol ; 47(6): 558-563, nov.-dic. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-186548

RESUMO

Introduction and objectives: Food allergy in school children ranges between 5.7 and 6.4% in Turkey. Studies emphasize the importance of improving school personnel's self-efficacy in managing food allergy and anaphylaxis. However, a brief and valid measurement tool for school personnel is not available in Turkey. The aim of this study was to determine the validity and reliability of the Turkish version of the School Personnel's Self-efficacy in Managing Food Allergy and Anaphylaxis (SPSMFAA-T) scale with teachers. Patients or materials and methods: This methodological study was conducted by 282 primary school teachers. Data were collected with a demographic characteristics form and SPSMFAA-T. The psychometric properties of the SPSMFAA-T were evaluated by content, discriminant, construct validity and internal consistency. Results: Cronbach's alpha for the scale was 0.91 and item-total correlations were between 0.50 and 0.82 (p < 0.001). The discriminant validity suggested that the scale successfully discriminated the teachers who had training on food allergy and anaphylaxis from the teachers who did not. The model fit indices of scale were determined to be the root mean square error of approximation (RMSEA) at 0.08, goodness of fit index (GFI) at 0.96, comparative fit index (CFI) at 0.99. Conclusions: The results supported that the SPSMFAA-T was a valid and reliable measurement tool to assess Turkish teachers’ self-efficacy levels to manage food allergy and anaphylaxis in school setting. The scale can be used in education programs to improve school personnel's skills to manage food allergy and anaphylaxis


No disponible


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Autoeficácia , Hipersensibilidade Alimentar/diagnóstico , Anafilaxia/terapia , Psicometria/métodos , Docentes/estatística & dados numéricos , Hipersensibilidade Alimentar/terapia , Psicometria/instrumentação , Turquia , Análise Fatorial , Análise de Regressão
9.
Allergol. immunopatol ; 47(6): 604-618, nov.-dic. 2019. tab, graf, mapas
Artigo em Inglês | IBECS | ID: ibc-186555

RESUMO

Background: Undesirable immunological responses to alimentary allergens are one of the hallmarks of atopic diseases. The prevalence of common food allergens is dissimilar among different communities with distinct nutritional habits and genetic characteristics. Aim: To assess the prevalence of the most common food allergens in Iran, using different reliable studies. Methods: All studies determining sensitization to common food allergens that were indexed in PubMed, Web of Science, Google Scholar, ProQuest, Scopus, Iran Medex, and Magiran were included in this review. To perform a meta-analysis, STATA 14 and metaprop command was applied. A logistic-normal random-effects model with Freeman-Tukey double arcsin transformation was applied to combine the findings of different studies and evaluate their heterogeneity. Random pooled estimate (ES) (pooled prevalence), 95% confidence interval (95% CI) and p-value were determined. Results: A total of 23 studies with data from a total of 6126 children and adults met the inclusion criteria for entering this meta-analysis. The respective pooled prevalence of a positive family history of allergy and positive specific IgE to at least one food allergen was 72% (95% CI: 66-77%) and 41% (95% CI: 33-49%), respectively. Our results in the total population revealed that allergic sensitization to egg yolk, cow’s milk (CM), egg white, and wheat were 25% (95% CI: 16%-35%), 24% (95% CI: 19-29%), 23% (95% CI: 18%-28%), and 9% (95% CI: 6%-14%), respectively. Walnut, peanut, and soybean sensitization was detected in 23% (95% CI: 17%-31%), 23% (95% CI: 13%-33%), and 20% (95% CI: 12%-28%) of patients, respectively. Random pooled ES for sensitization to shrimp and fish was 32% (95% CI: 21-45%) and 12% (95% CI: 6-20%), respectively. The result of analysis in different age groups revealed that allergic sensitization to milk, egg white, and egg yolk declines in higher age groups; while shrimp sensitization increases in older patients. In patients with atopic dermatitis, egg white was the most frequent food allergen 29% (95% CI = 18-42%); while wheat was the least frequent 8% (95% CI = 4-14%). Conclusions: Considering the prevalence of different food allergens, the results of the current meta-analysis revealed that egg yolk and cow’s milk had the second and third rate after shrimp, respectively. The high prevalence of sensitization to shrimp may be attributed to its high consumption in coastal areas and/or cross-reactivity of shrimp with some aeroallergens such as mites


No disponible


Assuntos
Humanos , Masculino , Feminino , Criança , Adulto , Hipersensibilidade Alimentar/imunologia , Alérgenos/imunologia , Hipersensibilidade Imediata/imunologia , Hipersensibilidade Alimentar/epidemiologia , Irã (Geográfico) , Ácaros/imunologia , Hipersensibilidade a Leite/imunologia
10.
Rev. lab. clín ; 12(4): 179-188, oct.-dic. 2019. ilus, tab, mapas, graf
Artigo em Espanhol | IBECS | ID: ibc-187318

RESUMO

La alergia al látex es una respuesta alterada de nuestro organismo al contactar con las proteínas que se encuentran en el látex de caucho natural. Los síntomas de la hipersensibilidad alérgica al látex son bastante parecidos a los de la alergia a los alimentos, siendo menos frecuentes los síntomas digestivos y más típicos los cutáneos tras el uso de guantes de látex, y los nasales y/o el asma tras la inhalación del polvo de los guantes de látex o de los globos. En caso de pacientes muy sensibles puede provocar reacciones alérgicas graves si entra en contacto con mucosas o cavidades internas. Se da la paradoja de que el medio hospitalario, es el lugar de más riesgo dada la cantidad existente de látex, tanto directo como indirecto. Las personas alérgicas al látex presentan a menudo reacciones alérgicas cruzadas, a veces graves, tras ingerir determinadas frutas y vegetales. Las reacciones cruzadas se deben a los alérgenos comunes presentes en el látex y en los diferentes alimentos. Es importante utilizar el análisis molecular de alérgenos para detectar falsos diagnósticos a látex por problemas de reactividad cruzada con proteínas de frutas. Indicamos cómo estas nuevas pruebas han sustituido a análisis menos precisos y eficientes, logrando un considerable ahorro de recursos


Latex allergy is an altered response of the body on contact with proteins found in natural rubber latex. The symptoms of allergic hypersensitivity to latex are quite similar to those of food allergy, with the gastrointestinal symptoms being less frequent and the cutaneous ones being more typical after the use of latex and nasal gloves and / or the asthma after the inhalation of the dust from latex gloves or balloons. In the case of very sensitive patients it can cause severe allergic reactions if it comes in contact with mucous membranes or internal cavities. There is a paradox that the hospital environment is the most risky place, given the existing amount of latex in direct and indirect use. People who are allergic to latex often have cross-allergic reactions, sometimes severe, after eating certain fruits and vegetables. The cross-reactions are due to the common allergens present in latex and in different foods. It is important to use molecular allergen analysis to detect false latex diagnoses due to problems of cross-reactivity with fruit proteins. It is indicated how these new tests have replaced less accurate and efficient analyses, achieving a considerable saving of resources


Assuntos
Humanos , Hipersensibilidade ao Látex/diagnóstico , Técnicas de Diagnóstico Molecular/métodos , Testes Genéticos/métodos , Reações Cruzadas/imunologia , Hipersensibilidade Alimentar/diagnóstico , Alérgenos/imunologia , Hipersensibilidade Imediata/imunologia
11.
Allergol. immunopatol ; 47(5): 484-490, sept.-oct. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186523

RESUMO

Introduction and objectives: Preschool-aged group is frequently affected by urticaria, and infections are the most frequently documented factors that cause acute urticaria in children. This prospective study was designed to investigate the underlying factors of acute urticaria in under five-year-old children and to describe predictive factors for progression to chronicity or recurrence after the first attack. Patients and methods: Children younger than five years of age with acute urticaria were recruited between July 2015 and July 2016. Patients (n = 83) were grouped into those below and above two years of age. In order to assess the risk factors for progression to chronicity or recurrence, logistic regression analysis was performed. Results: Upper respiratory tract infection was the most common detectable reason for acute urticaria (49.4%). Herpes Simplex Virus type 1 was significantly isolated in the cases with the manifestation of an acute single-episode urticaria (p = 0.042). Angioedema and food allergy were predominantly observed under two years old (p = 0.001, p = 0.006 respectively). A positive relationship was determined between the duration of urticaria and chronicity (r = 0.301, p = 0.006). The absence of atopic dermatitis (OR: 6.95, 95% CI: 1.35-35.67, p = 0.020), negative Herpes virus serology (OR: 4.25, 95% CI: 0.83-21.56, p = 0.040), and unknown etiology (OR: 3.30, 95% CI: 1.12-9.71, p = 0.030) were the independent risk factors for recurrent urticaria. Conclusions: Preschool-aged children with acute urticaria should be evaluated for infections at the time of admission. Patients with unknown etiology, negative Herpes virus serology, absence of atopic dermatitis, and long lasting urticaria should be followed up for chronicity and recurrence


No disponible


Assuntos
Humanos , Masculino , Feminino , Lactente , Anticorpos Antivirais/sangue , Pré-Escolar , Hipersensibilidade Alimentar/epidemiologia , Herpes Simples/epidemiologia , Herpesvirus Humano 1/fisiologia , Infecções Respiratórias/epidemiologia , Urticária/epidemiologia , Doença Aguda , Doença Crônica , Progressão da Doença , Valor Preditivo dos Testes , Prognóstico , Estudos Prospectivos , Risco
12.
Allergol. immunopatol ; 47(4): 342-349, jul.-ago. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-186505

RESUMO

Introduction and objectives: A standardised questionnaire may be an excellent tool for epidemiological studies aiming at screening children with suspected food allergies. Thus, the aim of the present study was to develop a screening questionnaire for assessing children with suspected food allergy and to analyse its reproducibility. Materials and methods: A questionnaire of adverse food reactions was developed by literary review of similar questionnaires validated in other countries as well as less well defined, non-validated Portuguese questionnaires. Peer review of the questionnaire by a panel of specialists and subsequent exploratory analysis was carried out by applying the questionnaire in children with confirmed food allergy. Test-retest analysis was performed by giving a face-to-face questionnaire to 159 children with suspected adverse food reactions, aged between three and 11 years. Temporal stability using Spearman Rho correlation test and reproducibility was studied using Cohen's Kappa index. Results: 115 children confirmed adverse food reactions that occurred with one or more foods. Retest was given about three weeks after the test, to 50 of these children who were randomly selected. The questionnaire showed good temporal stability (Spearman correlation coefficient of 0.834), and good reproducibility (only two of the 27 items had a Kappa index < 0.60). Conclusions. This questionnaire showed good temporal stability and reproducibility. Its validation for screening children with suspected food allergy will allow a standardised approach to diagnosis and comparison of results obtained in different centres


No disponible


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Hipersensibilidade Alimentar/diagnóstico , Inquéritos e Questionários , Alérgenos/imunologia , Grupos Étnicos , Alimentos , Hipersensibilidade Alimentar/epidemiologia , Programas de Rastreamento , Pais , Portugal/epidemiologia , Qualidade de Vida , Reprodutibilidade dos Testes
13.
Allergol. immunopatol ; 47(4): 401-408, jul.-ago. 2019. graf, ilus
Artigo em Inglês | IBECS | ID: ibc-186512

RESUMO

The variety of foods and methods of preparation are part of the cultural identity of each population, and thus the main foods that cause symptoms vary among different regions. Due to their increasing frequency, Adverse Reactions to Food (AFR) have been the subject of extensive study, especially in North America and Europe but few studies have been conducted in other areas, especially in populations located in the tropics and subtropics. In this article, we review available information on the epidemiology of food sensitization and food allergies in tropical regions and explore the different epidemiological data considering the major food involved, the underlying immune mechanism and clinical symptoms partners. In addition, we identify the possible limitations and questions that arise from studies conducted in tropical countries, which helps to generate objectives for future research


No disponible


Assuntos
Humanos , Dermatite Atópica/epidemiologia , Hipersensibilidade Alimentar/epidemiologia , Clima Tropical , Alérgenos/imunologia , África/epidemiologia , Ásia/epidemiologia , Imunização , Imunoglobulina E/metabolismo , América Latina/epidemiologia , Prevalência
15.
Allergol. immunopatol ; 47(3): 214-220, mayo-jun. 2019. graf, tab, ilus
Artigo em Inglês | IBECS | ID: ibc-186480

RESUMO

Background: Allergy to cow's milk proteins has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. This study evaluated the protective effect of taurine on intestinal damage induced by beta-lactoglobulin (Beta-Lg) in Balb/c mice used as an animal model of allergy to cow's milk proteins. Methods: Balb/c mice were treated with taurine administered orally by gavage (3 mmol/kg/day) or intraperitoneally (100 mg/kg/day) for two weeks, then sensitized intraperitoneally with Beta-Lg. The electrophysiological parameters: active ion transport of chloride (Short-circuit current: Isc) and the passive ion permeability (Conductance: G) were measured ex vivo in Ussing chamber by intestine challenge with Beta-Lg. Histological study was used to assess gut inflammation. Serum levels of TNF-α and IL-6 were measured. Serum IgG and IgE anti-Beta-Lg were determined by ELISA. Results: Compared with sensitized mice, Beta-Lg challenge of intestinal epithelium of taurine-pre-treated mice in Ussing chamber did not influence the intensity of Isc, nor produce any changes in the G, reflecting a reduction in the secretory response and epithelial permeability. Histological and morphometric analysis showed that taurine reduced the intestinal damage and limited intestine retraction caused by Beta-Lg sensitization. No statistically significant difference in the serum levels of TNF-α or IL-6 was found after oral or intraperitoneal administration of taurine. Treatment with taurine significantly decreased the IgG (p < 0.001) and IgE anti Beta-Lg levels (p < 0.05). Conclusions: These results have for the first time provided evidence that pre-treatment with taurine appears to prevent intestinal damage induced by Beta-Lg


No disponible


Assuntos
Animais , Feminino , Camundongos , Hipersensibilidade Alimentar/tratamento farmacológico , Inflamação/tratamento farmacológico , Mucosa Intestinal/efeitos dos fármacos , Taurina/uso terapêutico , Modelos Animais de Doenças , Alérgenos/imunologia , Imunidade Humoral/efeitos dos fármacos , Imunização , Imunoglobulina E/sangue , Imunoglobulina G/sangue , Interleucina-6/sangue , Mucosa Intestinal/imunologia , Lactoglobulinas/imunologia , Camundongos Endogâmicos BALB C , Fator de Necrose Tumoral alfa/sangue
16.
Allergol. immunopatol ; 47(3): 246-253, mayo-jun. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-186485

RESUMO

Background: The prevalence of food allergy is on the rise on a global scale. Objective: To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences. Methods: A cross-sectional study was carried out among 1992 adolescents (aged 15-18 years). Each adolescent answered a structured questionnaire. A multivariate analysis was used to identify the association between the variables. Results: The prevalence of FHS was 10.6% (the most commonly associated foods were shrimp, cow's milk and avocado) and the PFA was 7.8% (shrimp, cow's milk and pecan). The prevalences of oral allergy syndrome, food-associated urticaria and systemic reaction were 4.9%, 3.6% and 1.5%, respectively. The following factors were associated with FHS: personal history of asthma (OR 1.63; 95% CI: 1.11-2.41), allergic rhinitis (OR 2.60; 95% CI: 1.75-3.87), atopic dermatitis (OR 2.07; 95% CI: 1.25-3.43), maternal history of asthma (OR 1.80; 95% CI: 1.02-3.16), atopic dermatitis (OR 6.11; 95% CI: 2.45-15.29), and female sex (OR 1.89; 95% CI: 1.38-2.59). PFA was associated with a personal history of asthma (OR 1.65; 95% CI: 1.06-2.56), allergic rhinitis (OR 2.46; 95% CI: 1.56-3.88), atopic dermatitis (OR 2.02; 95% CI: 1.15-3.54), paternal allergic rhinitis (OR 2.52; 95% CI: 1.15-5.51), maternal atopic dermatitis (OR 7.46; 95% CI: 2.93-19.00), and female sex (OR 1.89; 95% CI: 1.31-2.72). Conclusion: The adverse reactions associated with foods among late adolescents are a frequent occurrence, and the most commonly associated factor is atopy


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Assuntos
Humanos , Animais , Masculino , Feminino , Adolescente , Alérgenos/imunologia , Hipersensibilidade Alimentar/epidemiologia , Fatores Sexuais , Proteínas de Artrópodes/imunologia , Estudos Transversais , México/epidemiologia , Proteínas do Leite/imunologia , Penaeidae/imunologia , Persea/imunologia , Prevalência , Fatores de Risco , Autorrelato , Inquéritos e Questionários
17.
Allergol. immunopatol ; 47(3): 277-281, mayo-jun. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-186490

RESUMO

Introduction and objectives: The reproducibility of the adverse reaction increases the suggestiveness of a history of food allergy. However, the positive predictive value (PPV) of multiple adverse reaction episodes for the diagnosis of IgE-mediated food allergy is not known. This evaluation was the objective of our study. Patients and methods: We retrospectively studied 180 children with a history of non-anaphylactic adverse reactions after the ingestion of a food. All children had the prick test positive for the offending food and performed the oral food challenge (OFC) within 12 months after the last adverse reaction episode (ARE). We have evaluated whether increasing the number of ARE increased the probability that the OFC would be positive (failed). Results: 93 patients (52%) presented one ARE, 49 (27%) presented two ARE, 24 (13%) presented three ARE, 14 (8%) patients presented ≥ four ARE. The OFC was positive in 94/180 (52%). The outcome of the OFC was found to be positively correlated with the number of ARE (OR = 1.56; 95% CI = 1.16-2.09; p = 0.003). A PPV = 100% was observed with a number of ARE ≥ five. Conclusions: The number of ARE is an important predictor of the diagnosis of food allergy, although less than we would have imagined. The number of ARE could be used to increase the predictability of the diagnostic tests currently in use, to define clinical prediction rules alternative to OFC and easy to use in clinical practice


No disponible


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Anafilaxia/diagnóstico , Hipersensibilidade Alimentar/diagnóstico , Anafilaxia/epidemiologia , Administração Oral , Alérgenos/imunologia , Alimentos , Hipersensibilidade Alimentar/epidemiologia , Imunização , Imunoglobulina E/metabolismo , Itália/epidemiologia , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos
18.
Rev. clín. esp. (Ed. impr.) ; 219(4): 184-188, mayo 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-186529

RESUMO

Antecedentes y objetivo: La omega-5 gliadina (omega5G) se considera el alérgeno principal en la anafilaxia inducida por ejercicio dependiente del trigo (WDEIA). Estos pacientes presentan reacciones anafilácticas tras la ingesta de trigo y la realización de ejercicio físico. El objetivo de nuestro estudio es describir las principales características de 12pacientes con este diagnóstico. Materiales y métodos: Estudio descriptivo, retrospectivo, mediante revisión de historias clínicas de 12pacientes diagnosticados de hipersensibilidad a omega5G. Resultados: La edad media fue 37 años, el 50% varones y el 50% mujeres. La mayoría tenía antecedente de episodios similares sin estudiar. El tiempo de latencia variaba desde inmediato hasta 150 min. La clínica más frecuente fue la urticaria (83%), seguida de broncoespasmo (58%), angioedema (42%), hipotensión (25%) y síntomas gastrointestinales (16%). El cofactor más implicado fue el ejercicio físico. El estudio alergológico se realizó con prick test y determinación de IgE total y específicas. Conclusiones: La WDEIA es una forma de alergia alimentaria relativamente rara pero potencialmente grave, por lo que es importante su conocimiento para poder llegar a un correcto diagnóstico


Background and objectives: The omega-5 gliadin (omega5G) is considered the main allergen in wheat-dependent exercise-induced anaphylaxis (WDEIA). These patients experience anaphylactic reactions after consuming wheat and performing physical exercise. The aim of our study was to describe the main characteristics of 12 patients with this diagnosis. Material and methods: A descriptive, retrospective study was conducted by reviewing the medical records of 12 patients diagnosed with omega-5G hypersensitivity. Results: The patients' mean age was 37 years, with 50% men and 50% women. Most of the patients had a history of similar unexamined episodes. The latency period varied from immediate to 150min. The most common symptoms were urticaria (83%), bronchospasms (58%), angio-oedema (42%), hypotension (25%) and gastrointestinal symptoms (16%). The most often involved cofactor was physical exercise. The allergy study was conducted with prick tests and total and specific IgE readings. Conclusions: WDEIA is a relatively rare but potentially severe food allergy. Understanding this allergy is therefore important for a correct diagnosis


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Hipersensibilidade a Trigo/diagnóstico , Asma Induzida por Exercício/diagnóstico , Anafilaxia/diagnóstico , Gliadina/efeitos adversos , Estudos Retrospectivos , Hipersensibilidade Alimentar/diagnóstico , Fatores Imunológicos/análise
20.
Allergol. immunopatol ; 47(2): 152-158, mar.-abr. 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-180803

RESUMO

Introduction and objectives: Long-term follow up of patients with hyper IgE syndrome (HIES), as a primary immunodeficiency disorder, has been poorly investigated. This study describes common clinical and immunological features of patients with HIES in the last 10 years in Shiraz University of Medical Sciences, Shiraz, Iran. Methods and patients: In this cross-sectional study, the symptoms and medical records of 18 patients, who were diagnosed with HIES, were observed. Genetic and immunologic study was also performed. Results: Eighteen patients with the mean age of 13 years old were investigated. Ten patients were detected to have mutations in DOCK8 gene and autosomal recessive HIES (AR-HIES); and four patients were found with STAT3 mutation and autosomal dominant HIES (AD-HIES). So, 14 patients with known genetic results were considered for further data analysis. Food allergy, eczema, viral and skin infections were the major complications of AR-HIES patients. The major clinical complications of AD-HIES patients were pneumonia, skin infections and eczema. Food allergy and viral infection were significantly higher in DOCK8 deficient patients. The most common causes of hospitalization in both AR-HIES and AD-HIES patients were pneumonia, skin infections and sepsis. The most common cause of death was found to be sepsis. Conclusions; AD-HIES and AR-HIES cannot be differentiated only based on the clinical presentations. Genetic features are also necessary for better diagnosis. This study, summarizing the clinical, immunological and genetic information of the patients with AD-HIES and AR-HIES, may open a way for better diagnosis and management of HIES


No disponible


Assuntos
Humanos , Masculino , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Hipersensibilidade Alimentar/imunologia , Síndrome de Job/imunologia , Mutação/genética , Pneumonia/imunologia , Seguimentos , Hipersensibilidade Alimentar/genética , Predisposição Genética para Doença , Fatores de Troca do Nucleotídeo Guanina/genética , Síndrome de Job/genética , Fenótipo , Pneumonia/genética , Fator de Transcrição STAT3/genética
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