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1.
Rev. esp. pediatr. (Ed. impr.) ; 69(6): 312-318, nov.-dic. 2013.
Artigo em Espanhol | IBECS | ID: ibc-121268

RESUMO

La enfermedad metabólica ósea (EMO) es una compliación conocida en recién nacidos alimentados con nutrición parenteral total durante largos periodos de tiempo. La principal causa es un fracaso de suministra suficiente cantidad de calcio y fósforo cuando se emplean sales inorgánicas por su escasa solubilidad en las soluciones acuosas. Los compuestos orgánicos de fósforo son más compatibles con el calcio en las soluciones de nutrición parenteral. El principal objetivo de este estudio es evaluar la eficacia y la tolerancia clínica del glicerolfosfato sódico en comparación con el fosfato potásico en recién nacidos que precisen nutrición parental. Para ello se planificó une studio randomizado a doble ciego. Los pacientes eran divididos en dos grupos: uno fue tratado conglicerolfosfato y otro con fosfato inorgánico. Las concentracioens plasmáticas en el tiempo del calcio y el fósforo fueron escogidas como variables priamrias de eficacia. El calcio y fosforo acumulado en orina fueron escogidas ocmo variables secundarias de eficacia. Para evaluar la seguridad se controlaron parámetros clíncios y de laboratorio y fueron protocolizados los posibles efectos adversos. Cuarenta y tres recién nacidos fueron incluidos. Después de analizar los datos obtenidos durante el estudio no encontramos diferencias para las variables estudiadas en los dos productos. Concluimos que el glicerolfosfato es un productos de eficacia y seguridad similar al fósforo inorgánico para la suplementación del fósforo en las soluciones de nutrición parental del recién nacido (AU)


The metabolic bone disease is a well-kinown complciation in newborn children fed with long-germ parenteral nutrition. The principal cuase is a failure to supply a sufficient queantity of calcium and phosphorus it due to the solubility of these salts in aqueous solutions. It has been shown that orbaic phosphorus compounds are more compatible with calcium in parenteral nutrition solutions. The aim of this sutdy is to evaluate the efficacy and tolerance of sodium glycerophosphate in comparison with potassium phosphate in newborns who require parenteral nutrition. A randomized double-blind clinical study was planned. The patients wer divided into two groups: one was treated with glycerophosphate, the other with potassium phosphate. Calciuma nd phosphorus plasma concentrations through time were taken as primary efficacy variable, while the acculated urinay excretion of calcium and phosphorus constituted the secondary efficacy variable. For safety evaluation, the clinical andd laboratory parameters specified in the protocol were controlled, and any adverse event was protocolled. Forty three newborns were included. After analysing the data obtained during the sutdy of the area under the curve, we obtained a p>0,05 both for phosphorus and calciumin plasma. The same result was reached after analysing the secondary efficacy variable. The clinical characteristics and safety variables showed a similar pattern in both groups. We may conclude that sodium glycerophosphate is a product of equal efficacy and safety as potassium phosphate for supplementton of phosphorus in parenteral nutrition solutions (AU)


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Fósforo/análise , Nutrição Parenteral/métodos , Soluções de Nutrição Parenteral/farmacologia , Glicerofosfatos/uso terapêutico , Doenças Ósseas Metabólicas/diagnóstico , Segurança do Paciente
2.
Med. oral patol. oral cir. bucal (Internet) ; 14(5): e257-e262, mayo 2009. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-136151

RESUMO

Objectives: The aim of this in vitro study was to compare the remineralizing effect of three rinses: (A) 0.17% sodium monofluor- phosphate and 0.05% calcium glycerophosphate (220 ppm fluoride), (B) 0.05% sodium fluoride (220 ppm fluoride) and (C) control mouthrinse (without fluoride or calcium). Method and Materials: Demineralized areas were created in 90 pieces of bovine enamel by submerging them in an acid solution (pH 4.4) for 48 hours. Part of the surface was painted with nail varnish to preserve the demineralized area and the specimens were assigned at random to three groups. The specimens were stored in artificial saliva at pH 7 and 37oC for 30 days. Twice daily they were immersed for 60 seconds in the respective mouthrinse. Following the experimental period, the specimens were bisected and examined by scanning electron microscopy. Results: The mean percentage of remineralization produced by the mouthrinses was as follows: (A) 54.08 (95% CI 46.37- 61.78), (B) 38.43 (95% CI 30.89-45.98) and (C) 30.18 (95% CI 25.56-34.80). The differences between the three groups were statistically significant. Conclusion: The results show that the fluoride and calcium mouthrinse has a significantly greater remineralizing capacity than the fluoride mouthrinse with the same fluoride ion concentration under the in vitro conditions of this study (AU)


Assuntos
Animais , Bovinos , Cariostáticos/farmacologia , Esmalte Dentário , Fluoretos/farmacologia , Glicerofosfatos/farmacologia , Antissépticos Bucais/farmacologia , Fosfatos/farmacologia , Fluoreto de Sódio/farmacologia , Remineralização Dentária
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