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1.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 47(2): 51-57, abr.-jun. 2020. graf, ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-191314

RESUMO

Los miomas uterinos son una de las patologías ginecológicas más comunes encontrándose hasta en el 70% de las mujeres de raza caucásica y en el 80% de las mujeres de raza negra1,2. En los últimos años, la angiogénesis y la vascularización se han convertido en pieza fundamental de estudio del crecimiento de los tumores. En el caso de los miomas uterinos se ha descubierto que existen diferencias en la vascularización cuando se compara con el tejido uterino adyacente. La patogenia de los miomas es multifactorial existiendo varias vías que intervienen en el crecimiento de los mismos como la vía estrogénica, la progestagénica y la de los factores de crecimiento3. Otra de las vías qué influyen en su desarrollo es la vía de la vitamina D. Niveles inadecuados de dicha vitamina pueden favorecer el crecimiento de los mismos. En nuestro trabajo hemos analizado cómo influye la terapia con vitamina D en el volumen de los miomas y en su vascularización mediante el análisis sérico de VEGF y ecografía 3 DPW


Uterine fibroids are one of the most common gynaecological disorders, being found in 70% of Caucasian women and 80% of Afro-Caribbean women 1,2. In recent years, angiogenesis and vascularisation have become a key part of study of tumour growth. Differences in vascularisation have been discovered in uterine fibroids when compared to adjacent uterine tissue. The pathogenesis of uterine fibroids is multifactorial. Several pathways are involved in their growth have been described, such as the oestrogen pathway, the gestagen pathway, and the pathway of the growth factors. Another of the pathways that influences their development is the vitamin D pathway, as inadequate levels of this vitamin may favour the growth of uterine fibroids3. In this work, an analysis is made on how vitamin D therapy influences the volume and vascularity of uterine fibroids, using serum VEGF levels and 3DPW Ultrasound


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Leiomioma/diagnóstico por imagem , Leiomioma/terapia , Projetos Piloto , Vitamina D/administração & dosagem , Neovascularização Patológica/diagnóstico por imagem , Fatores de Crescimento Endotelial/sangue , Leiomioma/patologia , Neovascularização Patológica/sangue , Neovascularização Patológica/patologia , Ultrassonografia Pré-Natal/métodos , Leiomioma/classificação
2.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 47(2): 51-57, abr.-jun. 2020. graf, ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-ET2-5379

RESUMO

Los miomas uterinos son una de las patologías ginecológicas más comunes encontrándose hasta en el 70% de las mujeres de raza caucásica y en el 80% de las mujeres de raza negra1,2. En los últimos años, la angiogénesis y la vascularización se han convertido en pieza fundamental de estudio del crecimiento de los tumores. En el caso de los miomas uterinos se ha descubierto que existen diferencias en la vascularización cuando se compara con el tejido uterino adyacente. La patogenia de los miomas es multifactorial existiendo varias vías que intervienen en el crecimiento de los mismos como la vía estrogénica, la progestagénica y la de los factores de crecimiento3. Otra de las vías qué influyen en su desarrollo es la vía de la vitamina D. Niveles inadecuados de dicha vitamina pueden favorecer el crecimiento de los mismos. En nuestro trabajo hemos analizado cómo influye la terapia con vitamina D en el volumen de los miomas y en su vascularización mediante el análisis sérico de VEGF y ecografía 3 DPW


Uterine fibroids are one of the most common gynaecological disorders, being found in 70% of Caucasian women and 80% of Afro-Caribbean women 1,2. In recent years, angiogenesis and vascularisation have become a key part of study of tumour growth. Differences in vascularisation have been discovered in uterine fibroids when compared to adjacent uterine tissue. The pathogenesis of uterine fibroids is multifactorial. Several pathways are involved in their growth have been described, such as the oestrogen pathway, the gestagen pathway, and the pathway of the growth factors. Another of the pathways that influences their development is the vitamin D pathway, as inadequate levels of this vitamin may favour the growth of uterine fibroids3. In this work, an analysis is made on how vitamin D therapy influences the volume and vascularity of uterine fibroids, using serum VEGF levels and 3DPW Ultrasound


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Leiomioma/diagnóstico por imagem , Leiomioma/terapia , Projetos Piloto , Vitamina D/administração & dosagem , Neovascularização Patológica/diagnóstico por imagem , Fatores de Crescimento Endotelial/sangue , Leiomioma/patologia , Neovascularização Patológica/sangue , Neovascularização Patológica/patologia , Ultrassonografia Pré-Natal/métodos , Leiomioma/classificação
3.
Nutr. hosp ; 37(2): 327-334, mar.-abr. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-190598

RESUMO

INTRODUCTION: vitamin D is involved in recovery after an osteoporotic hip fracture (OHF). Previous studies have reported decreased serum vitamin D levels during fracture healing. OBJECTIVES: our aim was to evaluate: a) serum 25-hydroxyvitamin D3 (25OHD3) levels in patients with OHF at hospital admission and 8 days post-admission, and b) the relationship between 25OHD levels and clinical outcomes. METHODS: a prospective study including 66 patients aged over 65 years hospitalized for OHF. We gathered data on baseline demographic characteristics, medical history, Mini Mental State (MMS) assessment, Activities of Daily Living (ADL) results, nutritional assessment, and type of fracture and surgery. Laboratory results were collected on bone biomarkers, albumin, 25OHD3, and IL6. Clinical outcomes included length of stay, complications, and mortality. In the statistical analysis, a t-test was used for continuous variables and a chi-square test for qualitative variables. Linear regression models were used for the multivariate analysis, adjusted for covariates. RESULTS: our study population had low serum vitamin D levels at admission, with a mean [(standard error of the mean (SEM)] of 12.04 (1.03) ng/mL. Both 25OHD3 and interleukin 6 (IL-6) levels significantly declined (p < 0.001) during the early post-fracture phase. A greater decline in 25OHD3 levels was significantly associated with longer hospital stay (p = 0.042, multivariate analysis). Serum 25OHD3 levels were also associated with cognitive status as assessed using the MMS exam. CONCLUSIONS: 25OHD3 levels were reduced in OHF patients at admission, and significantly decreased during the first 8 days post-admission. 25OHD3 levels were associated with MMS-assessed cognitive status. A greater decline in serum 25OHD3 was associated with a longer hospital stay


INTRODUCCIÓN: la vitamina D se ha relacionado con la recuperación tras la fractura osteoporótica de cadera (FOC). Estudios previos muestran un descenso de los niveles de vitamina D en la fase precoz tras la fractura. OBJETIVOS: evaluar: a) los niveles séricos de 25-hidroxivitamina D3 (25OHD3) al ingreso y a los 8 días del ingreso en hospitalizados por FOC; b) la relación de los niveles de 25OHD3 con los resultados clínicos, así como con el nivel cognitivo y funcional. MÉTODOS: estudio prospectivo de 66 pacientes (> 65 años) ingresados por FOC. Se estudiaron las características demográficas, los antecedentes personales, la valoración nutricional, el test Mini Mental State (MMS), el cuestionario Activities of Daily Living (ADL), el tipo de fractura y de cirugía, y parámetros bioquímicos del metabolismo óseo, la 25OHD3, la albúmina y la interleuquina 6. Como resultados clínicos se analizaron: estancia hospitalaria, complicaciones y mortalidad durante el ingreso. El análisis estadístico consistió en: a) prueba de la t para las variables continuas y χ2 para las cualitativas; b) análisis multivariable utilizando modelos de regresión lineal ajustados según el análisis de la covarianza. RESULTADOS: la población estudiada muestra niveles bajos de 25OHD3 al ingreso: media [± error estándar de la media (EEM)] = 12,04 (1,03) ng/mL. Durante el ingreso, 25OHD3 e interleuquina 6 decrecen significativamente (p < 0,001). El descenso de 25OHD3 se asocia con la estancia hospitalaria (p = 0,042 en análisis multivariable). Los valores disminuidos de 25OHD3 se asocian a un bajo nivel cognitivo (p = 0,042). CONCLUSIONES: los pacientes ingresados por fractura osteoporótica de cadera tienen niveles bajos de 25OHD3 que decrecen significativamente tras 8 días de ingreso. El descenso de 25OHD3 se asocia significativamente a la estancia hospitalaria. Los niveles disminuidos de 25OHD3 se asocian a un peor estado cognitivo evaluado mediante el MMS


Assuntos
Humanos , Masculino , Feminino , Idoso , Conservadores da Densidade Óssea/administração & dosagem , Lesões do Quadril/complicações , Fraturas por Osteoporose/complicações , 25-Hidroxivitamina D 2/administração & dosagem , Deficiência de Vitamina D/complicações , Estudos Prospectivos , Valor Nutritivo , Receptores de Calcitriol/administração & dosagem , Estado Nutricional , Vitamina D/sangue , 25-Hidroxivitamina D 2/sangue
4.
Nutr. hosp ; 37(2): 335-342, mar.-abr. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-190599

RESUMO

INTRODUCTION: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. OBJECTIVES: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. METHODS: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D supplementation, and who were selected using a cluster random sampling design (n = 1,705). The analysis was focused on metabolic disorders (type-2 diabetes mellitus [T2DM] and obesity), autoimmune disorders, and mortality. Multivariate logistic regression analyses were performed. RESULTS: low 25-(OH)-D3 levels were reported in 1,433 (84.0 %) patients, of which 774 (45.4 %) had insufficiency (20-29 ng/mL) and 659 (38.6 %) patients had deficiency (< 20 ng/mL). Lower 25-(OH)-D3 levels in T2DM patients were associated with higher glycosylated hemoglobin levels (p < 0.001). Patients with 25-(OH)-D3 levels < 12.5 ng/mL had a higher mortality risk than those with levels ≥ 12.5 ng/mL (HR: 3.339; 95 % CI: 1.342-8.308). We observed lower 25-(OH)-D3 levels in patients with grade-III obesity (p = 0.01). We found a higher risk of 25-(OH)-D3 deficiency in rheumatoid arthritis, type-1 diabetes, and systemic lupus erythematosus (p = 0.032, p = 0.002, p = 0.049, respectively). CONCLUSIONS: we found a significant relationship between 25-(OH)-D3 levels and glycemic control, body mass index, autoimmune disease, and mortality risk. Nevertheless, whether hypovitaminosis D plays a causal role or is a consequence of chronic disease remains controversial


INTRODUCCIÓN: si la hipovitaminosis D constituye una causa general de mayor mortalidad o un marcador de mal pronóstico para la salud no se ha dilucidado por completo. OBJETIVOS: determinar la asociación de los niveles séricos de 25-hidroxivitamina D [25-(OH)-D3] con los parámetros clínico-bioquímicos y el riesgo de mortalidad en la enfermedad crónica. MÉTODOS: se revisaron los expedientes clínicos y recopilamos los parámetros clínico-bioquímicos de pacientes diagnosticados de enfermedades crónicas que tenían al menos una determinación de 25-(OH)-D3, con o sin suplemento de calcio y vitamina D, y que se seleccionaron mediante muestreo aleatorio por grupos (n = 1705). El análisis se centró en los trastornos metabólicos (diabetes mellitus de tipo 2 [DM2] y obesidad), los trastornos autoinmunes y la mortalidad. Se realizaron análisis multivariados de regresión logística. RESULTADOS: se encontraron niveles bajos de 25-(OH)-D3 en 1433 (84,0 %) pacientes, de los cuales 774 (45,4 %) tenían insuficiencia (20-29 ng/mL) y 659 (38,6 %) tenían deficiencia (< 20 ng/mL) de esta vitamina. Los niveles más bajos de 25-(OH)-D3 en los pacientes con DM2 se asociaron a niveles más altos de hemoglobina glucosilada (p < 0,001). Los pacientes con niveles de 25-(OH)-D3 < 12,5 ng/mL tenían mayor riesgo de mortalidad que aquellos con niveles ≥ 12,5 ng/mL (HR: 3,339; IC del 95 %: 1,342-8,308). Apreciamos niveles más bajos de 25-(OH)-D3 en los pacientes con obesidad de grado III (p = 0,01). Se encontró un mayor riesgo de deficiencia de 25-(OH)-D3 en la artritis reumatoide, la diabetes de tipo 1 y el lupus eritematoso sistémico (p = 0,032, p = 0,002, p = 0,049, respectivamente). CONCLUSIONES: apreciamos una relación significativa entre los niveles de 25-(OH)-D3 y el control glucémico, el índice de masa corporal, la enfermedad autoinmune y el riesgo de mortalidad. Sin embargo, sigue siendo controvertido si la hipovitaminosis D desempeña un papel causal o constituye una consecuencia de las enfermedades crónicas


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Vitamina D/análogos & derivados , Deficiência de Vitamina D/etiologia , Doença Crônica/mortalidade , 25-Hidroxivitamina D 2/administração & dosagem , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/diagnóstico , Modelos Logísticos , Diabetes Mellitus Tipo 2/complicações , Doenças Autoimunes/mortalidade
5.
Med. clín (Ed. impr.) ; 154(5): 151-156, mar. 2020. graf, tab
Artigo em Inglês | IBECS | ID: ibc-186626

RESUMO

Introduction and objectives: Previous observational studies have suggested that low vitamin D status is associated with high circulating C-reactive protein levels, as well as other plasma inflammatory cytokines. However, there is no study to explore the relationship between vitamin D status and Lp-PLA2, a new biomarker of vascular-specific inflammation. The aim of this study was to examine the association between vitamin D status and circulating Lp-PLA2 levels in subjects with type 2 diabetes mellitus. Material and methods: This descriptive cross-sectional study enrolled diabetic subjects who underwent physical examination at Taizhou People's Hospital between August 2016 and January 2017. Blood pressure, anthropometry, metabolic profiles, serum 25(OH)D levels and Lp-PLA2 mass levels were measured in all participants. Results: A total of 196 participants were recruited into this study. The vitamin D insufficiency group had higher serum LP-PLA2 levels than the vitamin D sufficiency group (t=−2.765, p=.005). A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=−0.364, p=0.009). However, no significant relationship between serum Lp-PLA2 concentration and 25(OH)D levels was observed in subjects with vitamin D sufficiency. Conclusions: From this cohort of patients with type 2 diabetes, regardless of traditional cardiovascular risk factors, we observed a statistically significant inverse relation between Lp-PLA2 and 25(OH)D at levels <30ng/mL


Introducción y objetivos: Los estudios observacionales previos han sugerido que la situación de los bajos niveles de la vitamina D está asociada a los altos niveles de la proteína C reactiva circulantes, así como a otras citoquinas inflamatorias en plasma. Sin embargo, no existe ningún estudio que explore la relación entre la situación de la vitamina D y la lipoproteína asociada a la fosfolipasa A2 (Lp-PLA2), un nuevo biomarcador de la inflamación específico vascular. El objetivo de este estudio fue examinar la asociación entre la situación de la vitamina D y los niveles circulantes de Lp-PLA2 en sujetos con diabetes mellitus tipo 2. Material y métodos: Estudio transversal descriptivo que incluyó sujetos diabéticos que fueron sometidos a un examen físico en el Hospital popular de Taizhou entre agosto de 2016 y enero de 2017. Se midieron en todos los participantes la presión arterial, la antropometría, los perfiles metabólicos, el suero de 25 (OH) niveles séricos de vitamina D y los niveles de masa de Lp-PLA2. Resultados: Un total de 196 participantes fueron reclutados para este estudio. El grupo de insuficiencia de la vitamina D reflejó unos niveles superiores de Lp-PLA2 que el grupo con suficiencia de vitamina D (T=−2,765; p=0,005). Se observó una correlación negativa significativa entre Lp-PLA2 y 25(OH)D en el grupo con insuficiencia de vitamina D (R=−0,364; p=0,009). Sin embargo, no se observó ninguna relación significativa entre la concentración sérica de Lp-PLA2 y 25(OH)D en sujetos con niveles de suficiencia de vitamina D. Conclusiones: A partir de esta cohorte de pacientes con diabetes tipo 2, independientemente de los factores de riesgo cardiovascular, se observó una relación inversa entre Lp-PLA2, estadísticamente significativa, en los niveles de 25(OH)D<30ng/ml


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Diabetes Mellitus Tipo 2/tratamento farmacológico , Fatores de Risco , Vitamina D/uso terapêutico , Receptores da Fosfolipase A2/uso terapêutico , Estudos de Coortes , Estudos Transversais , Pressão Sanguínea , Antropometria , Doenças Cardiovasculares , Deficiência de Vitamina D
6.
Allergol. immunopatol ; 48(1): 84-89, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186597

RESUMO

Background and objectives: Vitamin D status may be related to allergen sensitizations, but the evidence is inconsistent. The objective of this study was to assess whether serum 25-hydroxyvitamin D (25(OH)D) levels were associated with allergic sensitizations in early childhood. Methods: Data were collected from 2642 children who visited the Guangdong Women and Children's Hospital from January 2016 to May 2017 for routine health check-ups. Serum 25(OH)D levels were tested by electrochemiluminescence immunoassay. Allergic sensitizations including food and inhalant allergens were tested for specific IgE antibodies at one year (12 months 0 days through 12 months 30 days) and two years (24 months 0 days through 24 months 30 days) of age. Results: The mean level of serum 25(OH)D was 86.47 ± 27.55 nmol/L, with a high prevalence of vitamin D insufficiency (< 75 nmol/L) in children aged 0-2 years (36.8%). Lower 25(OH)D levels with serum total IgE of more than 200IU/mL (81.54 ± 25.53 nmol/L) compared with less than 100 IU/mL (87.92 ± 28.05 nmol/L). The common sensitization to allergens in children aged one and two years were milk (44.2%), cat epithelium (26.4%), egg (13.1%), dog epithelium (12.7%) and Dermatophagoides farinae (6.7%). After multivariate adjustment, data in 25(OH)D treated as a continuous variable or categories, no consistent associations were found between 25(OH)D levels and allergen-specific IgEs. Conclusions: Serum 25(OH)D level showed an inverse relationship with total IgE level in early childhood. However, there is lack of evidence to support associations between low 25(OH)D levels and allergic sensitization to various allergens


No disponible


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Vitamina D/análogos & derivados , Imunização/métodos , Imunoglobulina E/sangue , Hipersensibilidade/diagnóstico , Técnicas Imunoenzimáticas , Imunoglobulina E/imunologia , China
8.
Nutr. hosp ; 37(1): 21-27, ene.-feb. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-187570

RESUMO

Objective: to verify the association of serum concentrations of 25-hydroxyvitamin D and glycemic levels with the genetic variants rs1544410 and rs2228570 of the VDR gene in adolescents from the Northeast region of Brazil. Materials and methods: a cross-sectional epidemiological study with 208 adolescents from public schools in the city of João Pessoa (Paraíba, Brazil) between 15 and 19 years of age. Blood samples were collected for DNA extraction and analysis of polymorphisms rs1544410 and rs2228570, as well as biochemical analyses (25-hydroxyvitamin D, parathyroid hormone, calcium and glycemia). Results: the mean age was 17.7 (± 1.14) years. Half of adolescents had sufficient serum levels of 25-hydroxyvitamin D and the other half had insufficient/deficient vitamin. The most frequent genotypic distribution was bb and Ff and of lesser frequency BB and ff. There was a significant relationship between the genotypes of rs1544410 and glycemia values (p = 0.049) in the relationships between the genotypes BBxbb (p = 0.012) and Bbxbb (p = 0.037); (p = 0.036, OR = 2.15, 95 % CI = 1.05-4.41), and in the BB+Bb group analysis when compared to the bb (p = 0.025, OR = 1.89, 95 % CI = 1.08-3.29) presented higher risk of glycemia above the median. On the other hand, when Bb+bb was analyzed in relation to BB, adolescents had a greater chance of blood glucose below the median (p = 0.025, OR = 0.66, CI = 0.47-0.95). Conclusion: this study showed a significant relation of glycemia with the distribution of rs1544410 polymorphism genotypes


Objetivo: verificar la asociación de las concentraciones séricas de 25-hidroxivitamina D y los niveles de glucemia con las variantes genéticas rs1544410 y rs2228570 del gen VDR en adolescentes de la región noreste de Brasil. Materiales y métodos: se realizó un estudio epidemiológico transversal con 208 adolescentes de escuelas públicas en la ciudad de João Pessoa (Paraíba, Brasil) de entre 15 y 19 años de edad. Se recogieron muestras de sangre para la extracción de ADN y el análisis de los polimorfismos rs1544410 y rs2228570, así como para análisis bioquímicos (25-hidroxivitamina D, hormona paratiroidea, calcio y glucemia). Resultados: la edad media fue de 17,7 (± 1,14) años. La mitad de los adolescentes tenía niveles séricos suficientes de 25-hidroxivitamina D y la otra mitad, vitamina insuficiente/deficiente. La distribución genotípica más frecuente fue bb y Ff y la de menor frecuencia, BB y ff. Hubo una relación significativa entre los genotipos de rs1544410 y los valores de glucemia (p = 0,049) en las relaciones entre los genotipos BBxbb (p = 0,012) y Bbxbb (p = 0,037); (p = 0,036, OR = 2,15, IC 95 % = 1,05-4.41), y el análisis del grupo BB + Bb en comparación con el bb (p = 0,025, OR = 1,89, IC 95 % = 1,08-3,29) mostró un mayor el riesgo de glucemia, por encima de la mediana. Por otro lado, cuando se analizó Bb+bb en relación con la BB, los adolescentes tuvieron una mayor probabilidad de que la glucosa en sangre estuviera por debajo de la mediana (p = 0,025, OR = 0,66, IC = 0,47-0,95). Conclusión: este estudio mostró una relación significativa entre la glucemia y la distribución de genotipos de polimorfismo rs1544410


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Vitamina D/administração & dosagem , Índice Glicêmico/fisiologia , Calcifediol/uso terapêutico , Brasil , Calcifediol/sangue , Estudos Transversais , DNA/sangue , Hormônio Paratireóideo/sangue , Cálcio/sangue , Glicemia/análise , Biomarcadores/análise , Modelos Logísticos
9.
Nutr. hosp ; 37(1): 28-36, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-187571

RESUMO

Background: although supplementation with vitamin D has been reported as a main determinant of 25-hydroxyvitamin D status [25(OH)D] levels, there are limited data in regard to the factors associated with vitamin D supplementation in older adults. Aims: to examine the characteristics of participants associated with vitamin D supplement use and its effect on 25(OH)D concentrations according to bone mineral density (BMD). Methods: the present analysis was based on data from participants aged 60 years and older in the National Health and Nutrition Examination Survey. Logistic regression models were created to examine the demographic, lifestyle, and health characteristics associated with vitamin D supplementation. Moreover, general linear models were assembled to assess the effect of vitamin D supplement doses on 25(OH)D concentrations according to BMD status. Results: of 5,204 participants, 45.3 % reported taking vitamin D supplements, at least 400 IU per day. Overall, women, non-Hispanic whites, college education, former smokers, physical activity, and > 2 comorbidities were variables significantly associated with increased odds of taking vitamin D supplements. Notably, among subjects with osteoporosis, those taking vitamin D supplements between 400 and 800 IU per day had on average 20.7 nmol/L higher 25(OH)D concentrations compared with their non-user counterparts. Conclusions: demographic and healthy lifestyle characteristics are the main determinants of vitamin D supplement use among older adults. Moreover, even among subjects with low bone mass, vitamin D supplements between 400 and 800 IU per day are adequate to reach sufficient 25(OH)D concentrations


Antecedentes: si bien la suplementación con vitamina D es un determinante principal de los niveles séricos de 25-hidroxivitamina D [25(OH)D], pocos estudios han descrito los factores determinantes del uso de suplementos de vitamina D en los adultos mayores. Objetivos: examinar los factores determinantes del uso de suplementos de vitamina D y su efecto en los niveles de 25(OH)D según la densidad ósea. Métodos: el presente análisis se basó en datos de participantes de 60 años o más en la Encuesta Nacional de Examen de Salud y Nutrición de EUA. Se crearon modelos de regresión logística para examinar las características demográficas, de estilo de vida y de salud asociadas al uso de suplementos de vitamina D. Además, se usaron modelos lineales generales para evaluar, según la densidad ósea, el efecto de la suplementación de vitamina D en las concentraciones de 25(OH)D. Resultados: de 5204 sujetos, el 45,3 % informaron que tomaban suplementos de vitamina D, al menos 400 UI por día. En general, las mujeres, los blancos no hispanoamericanos, la educación universitaria, ser exfumador, la actividad física y > 2 comorbilidades fueron características asociadas al aumento de las probabilidades de tomar suplementos de vitamina D. En particular, entre los sujetos con osteoporosis, aquellos que tomaron suplementos de vitamina D en dosis de entre 400 y 800 UI por día tenían de promedio concentraciones 20,7 nmol/l más altas de 25(OH)D que sus homólogos no usuarios. Conclusiones: las características demográficas y un estilo de vida saludable son los principales factores asociados al uso de suplementos de vitamina D en los adultos mayores. Además, incluso entre los sujetos con densidad ósea baja, la suplementación con vitamina D entre 400 y 800 UI por día es adecuada para alcanzar los niveles óptimos de 25(OH)D


Assuntos
Humanos , Idoso , Vitamina D/administração & dosagem , Densidade Óssea/efeitos dos fármacos , Calcifediol/administração & dosagem , Atividade Motora , Estado Nutricional , Modelos Logísticos , Dosagem , Estudos Transversais , Inquéritos e Questionários
10.
Nutr. hosp ; 37(1): 160-168, ene.-feb. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-187587

RESUMO

Introducción: son escasos los trabajos que ofrecen una solución práctica a los requerimientos nutricionales del baloncesto actual. Este trabajo ofrece una propuesta teórico-práctica, basada en una revisión de la literatura de los últimos años. Objetivos: analizar la fatiga que produce un partido de baloncesto y ofrecer una solución práctica para acelerar la recuperación por medio de la alimentación. Métodos: búsqueda bibliográfica en la base de datos PubMed de revisiones bibliográficas de los últimos 15 años y artículos originales de los últimos 5 años. Resultados: el tipo de nutriente y los suplementos alimenticios, así como la cantidad y el momento de su ingesta, son variables fundamentales para acelerar la recuperación. Conclusiones: la alimentación antes, durante y después de un partido o de una sesión de entrenamiento exigente es fundamental para la rápida recuperación del jugador


Introduction: very few works offer a practical solution to understand the nutritional requirements of current basketball. This work offers a theoretical-practical proposal. Objectives: to analyze the fatigue produced during a basketball game and offer a practical solution to accelerate recovery through nutrition. Methods: a search of the PubMed bibliographic database for reviews from the last 15 years and original articles from the last 5 years on basketball. Results: type of nutrient and food supplements are essential for a quicker recovery, in addition to their timing and dose. Conclusions: nutrition before, during and after a game or a high-intensity training session plays a fundamental role in the recovery of the basketball player


Assuntos
Humanos , Basquetebol/fisiologia , Suplementos Nutricionais , Nutrientes/uso terapêutico , Necessidades Nutricionais , Vitamina D , Carboidratos , Nutrientes/classificação
12.
Pediatr. catalan ; 79(4): 127-132, oct.-dic. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-191077

RESUMO

FONAMENT: En els prematurs, uns nivells inadequats de vitamina D poden comportar més comorbiditat, però hi ha controvèrsia en les recomanacions de suplementació. OBJECTIU: Intentar correlacionar aportacions (dieta I suplementació) de vitamina D amb nivells inadequats d'aquesta vitamina. MÉTODE: Estudi descriptiu retrospectiu dels prematurs als quals se'ls determina calcifediol (25(OH)D3) entre els mesos de gener I desembre del 2016 al nostre centre. RESULTATS: Incloem 36 determinacions de 25(OH)D3 de 17 nadons (58,8% de sexe masculí) amb mediana d'edat gestacional de 29,8 setmanes (rang: 24,85-35,14) I mediana de pes de 980 g (rang: 420-2.220 g). La mediana d'edat en dies en el moment de l'extracció és 58,5 (rang: 6-188); la mediana de 25(OH)D3 és 53,92ng/ml (rang: 17,1-150). Segons el càlcul de les aportacions de vitamina D, s'obté una mediana de 885 U/dia (rang: 2-1416). Hi ha una correlació estadísticament significativa entre 25(OH)D3 plasmàtica I aportacions. El 75% que rep aportacions de <400 U tenen nivells insuficients; el 62,5% que rep >1.200 U tenen nivells tòxics. Dels que reben 400-1.200 U, el 84% tenen nivells òptims; hi ha diferència entre els que reben 400-800 U, amb un 60% amb nivells suficients, I els que reben 800-1.200 U, amb un 92% amb nivells adequats. Hi ha diferència en el percentatge de mostres amb nivells insuficients segons la classificació de 2009 respecte de l'actual. CONCLUSIONS: Les aportacions de vitamina D d'entre 800 I 1.200 U/dia s'associen a nivells òptims en un percentatge elevat de nadons. Les aportacions inferiors a 400 U o superiors a 1.200 U s'associen a nivells inadequats. L'alimentació per si sola no garanteix els requeriments necessaris de vitamina D, però és una dada essencial que s'ha de tenir en compte. Cal individualitzar la dosi segons els nivells plasmàtics


FUNDAMENTO: En los prematuros, unos niveles inadecuados de vitamina D pueden comportar mayor comorbilidad, pero existe controversia en las recomendaciones de suplementación. OBJETIVO: Intentar correlacionar aportaciones (dieta y suplementación) de vitamina D con niveles inadecuados de esta vitamina. MÉTODO: Estudio descriptivo retrospectivo de los prematuros a los que se les realiza determinación de calcifediol (25(OH)D3) entre enero y diciembre de 2016 en nuestro centro. RESULTADOS: Incluimos 36 determinaciones de 25(OH)D3 de 17 pacientes (58,8% de sexo masculino) con mediana de edad gestacional de 29,8 semanas (rango: 24,85-35,17) y mediana de peso de 980 g (rango: 420-2.220 g). La mediana de edad en días en el momento de la extracción es 58,5 (rango: 6-188); la mediana de 25(OH)D3 es 53,92 ng/ml (rango: 17,1-150). Según el cálculo de los aportes de vitamina D, se obtiene una mediana de 885 U/día (rango: 2-1.416). Existe una correlación estadísticamente significativa entre niveles de 25(OH)D3 y aportes. El 75% que recibe aportes de <400 U tienen niveles insuficientes; el 62,5% que recibe >1.200 U tienen niveles tóxicos. De los que reciben 400-1200 U, el 84% tienen niveles óptimos; existe diferencia entre aquellos que reciben 400-800 U, con un 60% con niveles suficientes, y los que reciben 800-1.200 U, con un 92% con niveles adecuados. Existe diferencia en el porcentaje de muestras con niveles insuficientes según la clasificación de 2009 versus la actual. CONCLUSIONES: Los aportes de vitamina D entre 800 y 1.200 U/día se asocian a niveles óptimos en un porcentaje elevado de prematuros. Las aportaciones inferiores a 400 U o superiores a 1.200 U se asocian a niveles inadecuados. La alimentación por sí sola no garantiza los requerimientos necesarios de vitamina D, pero es un dato esencial a tener en cuenta. Es necesario individualizar la dosis en función de los niveles plasmáticos


BACKGROUND: Inadequate levels of vitamin D in premature newborns may lead to additional comorbidities; however, controversy exists regarding recommendations for supplementation. OBJECTIVE: To analyze correlations between vitamin D intake (diet and supplementation) with inadequate calcifediol (25(OH)D3) levels. METHOD: Descriptive, retrospective study of premature babies, whose 25(OH)D3 levels were determined between January and December 2016, in our medical centre. RESULTS: Thirty-six plasma level determinations of 25(OH)D3 in 17 patients (58.8% male) with median gestational age of 29.8 weeks (range: 24.85-35.14) and median weight of 980g (range 420-2220). The median age in days was 58,5 (range: 6-188) at the moment of determination, and the median plasma level of 25(OH)D3 was 53,92ng/ml (range:17.1-150). The median vitamin D intake was 885U/day (range: 2-1416). There was a significant correlation between 25(OH)D3 levels and vitamin D intake. Seventy-five percent of patients who received <400U intake had insufficient levels; and 62,5% who received >1200 had toxic levels. Eighty-four percent of those who received between 400 and 1200U had adequate levels; 60% of premature newborns who received 400-800U had sufficient levels versus 92% of babies who received 800 to 1200U. There were differences in percentage of samples with insufficient levels according to 2009 classification versus the current one. CONCLUSIONS: In a high percentage of premature babies, 800-1200U vitamin D intake result in adequate levels. Vitamin D in-take of <400U or >1200U correlate with inadequate levels. It is important to consider that nutrition by itself doesn't guarantee the required vitamin D intake. Individualized doses are needed according to blood plasma levels


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Nutrição Enteral , Alimentos Fortificados , Vitamina D/administração & dosagem , Vitamina D/sangue , Calcifediol/administração & dosagem , Recém-Nascido Prematuro/sangue , Estudos Retrospectivos
14.
Nutr. hosp ; 36(6): 1418-1423, nov.-dic. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-191163

RESUMO

Vitamin D is a micronutrient that plays a large role in bone disease, and researchers are now discovering that it also does so in non-skeletal disease, thus making high-quality analytical determination necessary. To make this determination, a series of immunochemical and physical methods are used. These methods present a series of different ways of handling samples as well as different methodologies that bring a series of advantages and limitations based on the scope of work in which the vitamin D analysis methodology is applied. Although the Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) is the gold standard method of analytical vitamin D determination, and is the only one to offer a more complete and accurate view of all metabolites of this vitamin, it is necessary to standardize all the analysis methodologies that allow accurate, reliable and quality analytical determination, since it is essential to obtain results that can reliably be extrapolated to the population, and that can be decisive in assessing a large number of pathologies


La vitamina D es un micronutriente que ejerce un gran papel en enfermedades óseas y actualmente se está descubriendo que también lo hace en enfermedades no óseas, por lo que una determinación analítica de calidad es necesaria. Para realizar esta determinación se emplean una serie de métodos inmunoquímicos y físicos, los cuales van a presentar una serie de tratamientos diferentes de las muestras, así como diferentes metodologías que van a traer una serie de ventajas y limitaciones conforme al ámbito de trabajo en que se aplique la metodología de análisis de la vitamina D. A pesar de que la cromatografía líquida-espectrometría de masas en tándem (LC-MS/MS) es el método gold standard de determinación analítica de la vitamina D, y de que es el que ofrece una visión más completa y precisa de todos los metabolitos de esta vitamina, es necesaria una estandarización de todas las metodologías de análisis que permitan una determinación analítica precisa, fiable y de calidad, ya que es imprescindible obtener unos resultados que sean extrapolables con fiabilidad a la población y que puedan ser determinantes para valorar un gran número de patologías


Assuntos
Humanos , Vitamina D/sangue , Vitaminas/sangue , Análise Química do Sangue/métodos , Análise Química do Sangue/tendências , Manejo de Espécimes
15.
Endocrinol. diabetes nutr. (Ed. impr.) ; 66(10): 628-638, dic. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-184790

RESUMO

Background: Studies trying to find the association between vitamin D status and metabolic syndrome (MetS) have led to inconsistent results, and community-based data for individuals living in the Middle East are limited. Objectives: To find out if MetS and its components are associated with vitamin D status among female teachers residing in Yazd city during winter 2015. Materials and methods: A total of 276 female teachers (case group, n = 124 and control group, n = 152) aged 20-60 years were included. Weight, height, waist circumference, blood pressure, daily energy intake, physical activity, serum 25 hydroxy vitamin D (25(OH)D3), fasting blood glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C) levels were assessed. Logistic regression was used to examine the odds ratio of MetS according to vitamin D status. Results: Mean serum 25(OH)D3 was 32.79 ± 18.62 ng/ml and 33.73 ± 20.20, in females with and without MetS, respectively (P > 0.142). Compared to those with 25(OH)D3of < 20 ng/ml, the odds ratio for MetS was 1.01 (95% CI: 0.48-2.13) and 0.95 (95% CI: 0.56-1.60) for those with serum 25(OH)D3 levels of 20-29 ng/ml and ≥ 30 ng/ml, respectively (P trend = 0.84). The association remained insignificant after adjusting for potential confounders. Furthermore, vitamin D status was not associated with MetS components (P > 0.05). Conclusion: Although several studies have claimed the association between vitamin D status and MetS, we could not find a similar connection in a sample of Iranian female teachers. Prospective studies are needed to determine the possible effect of vitamin D in the development of MetS, particularly in the Yazd province


Antecedentes: Los estudios en busca de una asociación entre el estado de vitamina D y el síndrome metabólico (SM) han dado resultados no concluyentes, y los datos sobre comunidades de personas residentes en Oriente Próximo son limitados. Objetivos: Averiguar si existe asociación entre el SM y sus componentes y el estado de vitamina D en profesoras residentes en la ciudad de Yazd durante el invierno de 2015. Materiales y métodos: Se incluyó a un total de 276 profesoras (grupos de casos, n = 124 y grupo de control, n = 152) de 20-60 años de edad. Se determinaron el peso, la talla, el perímetro de la cintura, la presión arterial, la ingesta diaria de energía, la actividad física y los niveles de 25-hidroxivitamina D (25(OH)D3), glucosa en ayunas, triglicéridos y colesterol de las proteínas de alta densidad (C-HDL). Se utilizó regresión logística para determinar la razón de probabilidades de SM en función del estado de vitamina D. Resultados: La concentración sérica media de 25(OH)D3 era de 32,79 ± 18,62 ng/ml y 33,73 ± 20,20 en las mujeres con y sin SM, respectivamente (P > 0,142). En comparación con las que tenían < 20 ng/ml de 25(OH)D3, la razón de probabilidades de SM era 1,01 (IC al 95%, 0,48-2,13) y 0,95 (IC al 95%, 0,56-1,60) en las que tenían valores de 20-29 ng/ml y ≥ 30 ng/ml, respectivamente (tendencia de P = 0,84). La asociación seguía siendo no significativa después del ajuste por posibles factores de confusión. Además, el estado de vitamina D no se asociaba con los componentes del SM (P > 0,05). Conclusión: Aunque varios estudios han informado de una asociación entre el estado de la vitamina D y el SM, no pudimos hallar una relación similar en una muestra de profesoras iraníes. Se necesitan estudios prospectivos para determinar el posible efecto de la vitamina D en el desarrollo del SM, especialmente en la provincia de Yazd


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Vitamina D/administração & dosagem , Síndrome Metabólica/tratamento farmacológico , Deficiência de Vitamina D/dietoterapia , Irã (Geográfico) , Modelos Logísticos , Peso-Estatura , Relação Cintura-Quadril , Pressão Arterial , Pressão Sanguínea , Exercício Físico/fisiologia
16.
Allergol. immunopatol ; 47(6): 544-550, nov.-dic. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186546

RESUMO

Introduction and objectives: Cow's milk allergy (CMA) is common, especially in children. The treatment is based on the exclusion of milk and dairy products and guidance regarding the exclusion diet. This study aimed to compare the anthropometric measurements and food intake of children with CMA with those of healthy controls, and to evaluate the serum concentrations of Vitamin A and 25(OH)D in children with CMA. Methods: This is a cross-sectional study with 27 children in the CMA group and 30 in the control group. z-Scores of body mass index and height, skinfolds, food intake and serum concentrations of retinol, beta-carotene, lycopene, 25(OH)D, parathyroid hormone and high sensitivity C-reactive protein were evaluated. Results: Mean age was four years (± 1.9). The CMA group evidenced a lower height compared to those from the control group (p = 0.0043). The CMA group showed a lower intake of calcium (p = 0.0033) and lipids (p = 0.0123). Low serum concentrations of retinol, beta-carotene, lycopene, 25(OH)D were found in 25.9%, 59.3%, 48.1% and 70.3% of the CMA group, respectively. Conclusions: Children with CMA consume smaller amounts of calcium and lipids and have shorter height compared to healthy controls. Insufficient levels of vitamins A and D were frequent in the CMA group, emphasizing the need for nutritional guidance and monitoring


No disponible


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Estado Nutricional/imunologia , Consumo de Alimentos , Hipersensibilidade a Leite/imunologia , Nutrientes/uso terapêutico , Bovinos , Vitamina A , Antropometria , Estudos Transversais , Vitamina D , Inquéritos e Questionários , Análise de Variância
17.
Allergol. immunopatol ; 47(6): 570-578, nov.-dic. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-186550

RESUMO

Background: The key role of dietary factors in immunotolerance promotion and allergic diseases prevention has been emphasised. The aim of the study was the analysis of the impact of immunomodulatory dietary components, consumed by pregnant women, on the development of cow's milk allergy (CMA) in their offspring. Materials and methods: Fifty-one pairs of mothers and their CMA-offspring were included in the study group. The analysis of a daily intake of selected dietary components was conducted retrospectively with the application of a seven-day diet of a mother in the third trimester of gestation and the authors’ own questionnaire. The Diet 5.D programme was used. Results: An average daily retinol intake by study-group mothers was significantly lower than by control-group mothers and valued 375.6 μg/d vs. 543.7 μg/d (p = 0.040), respectively. Folates intake in the study group was 598.8 μg/d vs. 361.1μg/d in the control group (p = 0.001). Vitamin D in the study group was statistically lower - 3.6μg/d, comparing to the control group - 6.9 μg/d (p = .038). Average LC-PUFA intake by mothers with allergic children was 0.09g/d, while in the control group 0.18g/d (p = 0.016). An analysis of the diet revealed that significantly more mothers of children from the control group (n = 12; 48%) consumed fish 2-3 times per month in comparison to the study group (n = 9; 17.6%) (p = 0.007). Conclusions: Vitamin D, A, LC-PUFA, retinol, riboflavin and fish consumption by pregnant mothers of CMA-children was significantly lower, whereas beta-carotene and folates consumption was significantly higher than that of mothers with non-allergic children


No disponible


Assuntos
Humanos , Masculino , Feminino , Gravidez , Imunomodulação/imunologia , Complicações na Gravidez/dietoterapia , Complicações na Gravidez/imunologia , Hipersensibilidade a Leite/dietoterapia , Projetos Piloto , Dietoterapia , Polônia , Vitamina D , Consumo de Energia , Análise Fatorial , Fatores de Risco , Análise de Regressão , Relações Mãe-Filho , Análise Multivariada , Estudos Retrospectivos
18.
Allergol. immunopatol ; 47(6): 585-590, nov.-dic. 2019. graf
Artigo em Inglês | IBECS | ID: ibc-186552

RESUMO

Introduction and objectives: Transforming growth factor β1 (TGFβ1) and dysregulated microRNA-21 (miR-21) expression is associated with TGFβ/Smad signaling pathway activation and fibrosis. While calcitriol has been shown to improve airway remodeling in asthmatic mice, its mechanism remains unknown. In this study, the effect of calcitriol on the TGFβ/Smad signaling pathway and miR-21 expression in human bronchial fibroblasts was investigated to explore the mechanism of action of calcitriol and the inhaled glucocorticoid, budesonide, in airway remodeling. Materials and methods: Human bronchial fibroblasts were pretreated with budesonide, calcitriol, or budesonide plus calcitriol, and stimulated with TGFβ1 for 48h. Quantitative real-time PCR was used to determine the expression of miR-21. Western blot was used to determine airway remodeling-related proteins, TGFβ/Smad signaling pathway-related proteins, glucocorticoid receptor, and vitamin D receptor (VDR) expression. Results: Both budesonide and calcitriol down-regulated miR-21 expression in human bronchial fibroblasts, up-regulated Smad7 expression, and inhibited the expression of airway remodeling-related proteins. Both budesonide and calcitriol up-regulated the low expression of VDR induced by TGFβ1 in human bronchial fibroblasts. The expression of VDR in the combined treatment group (budesonide plus calcitriol) was significantly higher than that in the calcitriol treatment group. The expression of collagen type I in the combined treatment group was significantly lower than that in the calcitriol treatment group. Conclusions: Calcitriol can up-regulate the expression of VDR in human bronchial fibroblasts and exert an anti-airway remodeling effect. Budesonide can up-regulate the expression of VDR in human bronchial fibroblasts and enhance the inhibitory effect of calcitriol on airway remodeling


No disponible


Assuntos
Animais , Camundongos , Budesonida/uso terapêutico , Vitamina D/uso terapêutico , Fibroblastos/imunologia , Calcitriol/uso terapêutico , MicroRNAs/imunologia , Asma/imunologia , Fator de Crescimento Transformador beta1/imunologia , Western Blotting , Fator de Crescimento Transformador beta1/metabolismo , Análise de Variância
19.
Allergol. immunopatol ; 47(6): 591-597, nov.-dic. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-186553

RESUMO

Introduction and Objectives: Vitamin D deficiency is associated with increased susceptibility to infections and wheezing. We aimed to evaluate the relation between vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing. Materials and methods: A total of 52 patients who applied with wheezing, at the ages of 12-60 months with a history of three or more wheezing attacks in the last year and 54 healthy children were included. Sociodemographic data, risk factors for recurrent wheezing, and the severity of the wheezing attacks were recorded. 25(OH)D3, calcium, phosphor, alkaline phosphatase and parathormone levels of all children were measured. Nasopharyngeal samples of the patients for viruses were studied by multiplex polymerase chain reaction. Results: For the patient group, being breastfed for six months or less, history of cesarean section, cigarette exposure, humid home environment, and family history of allergic disease were significantly higher compared with the control group. Serum vitamin D levels in the patient group were significantly lower compared to the control group. There was no significant relationship between vitamin D levels and hospitalization, oxygen or steroid therapy. Virus was detected in 38 patients (73%). Rhinovirus (63.2%) was the most frequently detected virus. Coinfection was found in 14 (36.8%) patients. There was no statistically significant difference between detection of virus and vitamin D levels. Conclusions: Cigarette exposure, being breastfed six months or less, humid home environment, history of cesarean section, family history of allergic disease and vitamin D deficiency might be risk factors for recurrent wheezing


No disponible


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Viroses/imunologia , Vitamina D/uso terapêutico , Índice de Gravidade de Doença , Fatores de Risco , Coinfecção/imunologia , Infecções Respiratórias/imunologia , Sons Respiratórios/imunologia , Recidiva , Reação em Cadeia da Polimerase , Anormalidades Congênitas/imunologia , Pulmão/anormalidades , Pulmão/imunologia , Espectrofotometria/métodos , Sons Respiratórios/etiologia , Deficiência de Vitamina D
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