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1.
J. physiol. biochem ; 72(4): 669-678, dic. 2016. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-168374

RESUMO

High meat-product consumption has been related to cardiovascular disease (CVD). However, previous results suggest the benefits of consuming improved fat meat products on lipoprotein-cholesterol and anthropometric measurements. Present study aims to assess the effect of consuming different Pâté and Frankfurter formulations on emergent CVD biomarkers in male volunteers at increased CVD risk. Eighteen male volunteers with at least two CVD risk factors were enrolled in a sequentially controlled study where different pork-products were tested: reduced-fat (RF), omega-3-enriched-RF (n-3RF), and normal-fat (NF). Pork-products were consumed during 4-week periods separated by 4-week washout. The cardiometabolic index (CI), oxidized low density lipoproteins (oxLDL), apolipoproteins (Apo) A1 and B, homocysteine (tHcys), arylesterase (AE), C-reactive Protein (CRP), tumor necrotic factor-alpha (TNFα), and lipoprotein (a) (Lp(a)) were tested and some other related ratios calculated. AE, oxLDL and Lp(a), AE/HDLc, LDLc/Apo B, and AE/oxLDL rate of change were differently affected (P<0.01) by pork-products consumption. RF increased (P < 0.05) AE, AE/HDLc and AE/oxLDL ratios and decreased TNFα, tHcys; n-3RF increased (P < 0.001) AE, AE/HDLc and AE/oxLDL ratios and decreased (P < 0.05) Lp(a); while NF increased (P<0.05) oxLDL and Lp(a) levels. In conclusion, RF and n-3RF products affected positively the level of some emergent CVD markers. The high regular consumption of NF-products should be limited as significantly increased Lp(a) and oxLDL values. The high variability in response observed for some markers suggests the need to perform more studies to identify targets for RF- and n-3RF-products (AU)


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Assuntos
Humanos , Animais , Masculino , Adulto , Pessoa de Meia-Idade , Gorduras na Dieta/sangue , Carne Vermelha/análise , Doenças Cardiovasculares/sangue , Comportamento Alimentar , Homocisteína/sangue , Fatores de Risco , Voluntários , Ácidos Graxos Ômega-3/sangue , Biomarcadores/sangue , Apolipoproteínas/sangue , Proteína C-Reativa/metabolismo , Fator de Necrose Tumoral alfa/sangue , Hidrolases de Éster Carboxílico/sangue
2.
Med. intensiva (Madr., Ed. impr.) ; 40(2): 105-112, mar. 2016. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-151109

RESUMO

El traumatismo craneoencefálico grave es una entidad clínica con gran repercusión en términos socioeconómicos y de salud pública. Pese a los avances obtenidos en el ámbito del diagnóstico y tratamiento, no se han consolidado modelos predictivos suficientemente fiables que permitan desarrollar ensayos clínicos e impulsen estrategias terapéuticas efectivas que mejoren su pronóstico. En este sentido, durante las últimas décadas se han estudiado diversos biomarcadores de lesión cerebral con el fin de establecerlos como herramientas diagnósticas y pronósticas de la lesión traumática cerebral. Sin embargo, todos ellos presentan alguna limitación que impide su aplicación universalizada. Es necesario analizar las propiedades de los biomarcadores conocidos hasta la fecha, tanto los que tradicionalmente han demostrado correlación con la gravedad y pronóstico como aquellos que recientemente se anuncian prometedores. Para ello, convendría diseñar nuevos estudios que definan sus propiedades de forma aislada y que diluciden el papel de su uso combinado


Severe head injuries have a great socioeconomic and public health impact. Despite progress in diagnosis and treatment, no sufficiently reliable predictive models have been established for developing clinical trials and promoting effective therapeutic strategies capable of improving the prognosis. In the last decades, several brain damage biomarkers have been studied as potential diagnostic and prognostic tools in traumatic brain injury. However, all of them have limitations that preclude their universalized application. The properties of the known biomarkers -both those traditionally shown to correlate with severity and prognosis, and those recently announced as promising options- should be analyzed. New studies are needed to define their properties, both isolatedly and in combined use


Assuntos
Humanos , Traumatismos Craniocerebrais/fisiopatologia , Prognóstico , Biomarcadores/análise , Índice de Gravidade de Doença , Risco Ajustado/métodos , Fatores de Risco , Proteínas tau/análise , Ubiquitina/análise , Hidrolases de Éster Carboxílico/análise , Espectrina/análise , Proteínas de Neurofilamentos/análise
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