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1.
Allergol. immunopatol ; 44(4): 297-302, jul.-ago. 2016. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-154430

RESUMO

Background: Cathelicidin, an anti-microbial peptide, is a component of the innate immune system. Cathelicidin has anti-microbial, anti-inflammatory and immunoregulatory functions. Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has expanded in recent years. We measured levels of the LL-37 peptide in the nasal fluids of children with allergic rhinitis (AR) and investigated the possible role of this peptide in the pathogenesis of AR. Methods: The study population included 46 children who were newly diagnosed with AR and not taking any medication. Thirty-three healthy control subjects were also enrolled. Nasal secretions were collected from the study and control groups using a polyurethane sponge nasal secretion collector, and nasal fluid LL-37 levels were determined using the ELISA method. Results; The levels of LL-37 in the nasal fluid of the AR patients were lower than those of the control group (median of 2.3ng/ml [minimum-maximum, 2.1-3.2] vs. 2.6 ng/ml [2.1-5.4], respectively; p < 0.001), and they were significantly reduced in patients with moderate/severe AR compared with those of patients with mild AR (2.2 ng/ml [2.1-2.4] vs. 2.5 ng/ml [2.1-3.1], respectively; p < 0.001). Conclusion: Our results show that children with AR have reduced nasal fluid LL-37 levels compared with healthy controls. Additionally, children with moderate/severe AR have decreased nasal fluid LL-37 levels compared with children with mild AR. These findings highlight the role of cathelicidin in the pathogenesis of AR (AU)


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Assuntos
Humanos , Masculino , Feminino , Criança , Imunoglobulina E/análise , Imunoglobulina E/imunologia , Rinite Alérgica/etiologia , Rinite Alérgica/imunologia , Rinite Alérgica/fisiopatologia , Biópsia/métodos , Estudos de Casos e Controles , Catelicidinas/análise , Catelicidinas/imunologia , Catelicidinas , Defensinas/análise , Defensinas/imunologia , Defensinas
2.
Endocrinol. nutr. (Ed. impr.) ; 63(2): 87-94, feb. 2016. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-148491

RESUMO

El calcitriol ha sido considerado durante años exclusivamente como una hormona reguladora del metabolismo fosfocálcico, pero últimamente se ha demostrado que numerosas células implicadas en la inmunidad innata (epitelios de barrera, monocitos/macrófagos, etc.) son capaces de reconocer determinadas moléculas repetitivas características de diversos gérmenes patógenos mediante receptores de membrana o intranucleares. La activación de estos receptores induce la síntesis de la 1α-hidroxilasa, con lo que dichas células son capaces de sintetizar calcitriol a partir de la 25 hidroxivitamina D circulante. El calcitriol, a través del receptor la vitamina D, modula la expresión de determinados péptidos antimicrobianos, como la catelicidina, la β2-defensina o la hepcidina. Estos péptidos representan un mecanismo versátil de la lucha antibacteriana innata y su producción se ve alterada en la hipovitaminosis D. Se realiza un análisis de la literatura sobre sus mecanismos de secreción, las concentraciones en diversos líquidos orgánicos, y los mecanismos de acción y su relación con la vitamina D (AU)


Traditionally, calcitriol has been considered a calcium and phosphate regulating hormone, but has recently been shown to play a pivotal role in innate immunity. Many barrier and immune cells have membrane and intracellular receptors that recognize different microbial antigens. Activation of these receptors induces synthesis of 1α-hydroxylase, which acts on 25 hydroxyvitamin D to generate intracellular calcitriol. Calcitriol activates its receptor and enhances the synthesis of important human antibiotics like cathelicidin and β2-defensin while inhibiting hepcidin. These pluripotent peptides have an important role in innate immunity, and their regulation is abnormal in hypovitaminosis D. The literature on their secretion mechanisms, levels in different organic fluids, mechanism of action, and relationship with vitamin D is reviewed here (AU)


Assuntos
Humanos , Deficiência de Vitamina D/fisiopatologia , Antibacterianos/efeitos adversos , Antibacterianos/farmacocinética , Catelicidinas/farmacocinética , Defensinas/farmacocinética , Hepcidinas/farmacocinética , Calcitriol/farmacocinética
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