Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Intervalo de ano de publicação
3.
Artigo em Inglês | IBECS | ID: ibc-118261

RESUMO

The authors (Garcia Carrancá A, Zentero Galindo E, Jiménez Farfán MD and Hernandez Guerrero JC) express that one of the figures of the original article (Jacinto-Alemán LF, García-Carrancá A, Leyba Huerta ER, Zenteno-Galindo E, Jiménez-Farfán MD, Hernández-Guerrero JC. erbB expression changes in ethanol and 7,12- dimethylbenz (a)anthracene-induced oral carcinogenesis. Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18(2):e325-31.) corresponding to Western blots have not been found and the voluntary alteration of this figure is evident. The coauthors Alejandro García Carranca, Edgar Zenteno Galindo, Maria Dolores Jiménez Farfán and Juan Carlos Hernández Guerrero have made the decision to take back what has been published, as they have come to the conclusion, that at least this result is false.The editor declare that the journal had the signed copyright by the authors when the arti-cle was initially published. This copyright document certifies that the undersigned authors war-rants that the article is original; is not under consideration by another publication; and its tables or figures have not been previously published. The authors confirmed that the final ar-ticle had been read and each author ́s contribution had been approved by the appropriate author. The editor has made the decision to retract the article due to the above comments of some authors against the rest. The editors apologize to the readers and reviewers of Med Oral Patol Oral Cir Bucal for the incon-venience caused by the authors of the article


No disponible


Assuntos
Genes erbB , Etanol , Benzo(a)Antracenos
4.
Med. oral patol. oral cir. bucal (Internet) ; 18(2): 325-331, mar. 2013. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-112405

RESUMO

Objetive: The aim of this study was to determine erbB expression in normal mucosa, oral dysplasia, and invasive carcinomas developed in the hamster’s buccal pouch chemical carcinogenesis model. Study design: Fifty Syrian golden hamsters were equally divided in five groups (A-E); two controls and three experimental group exposed to alcohol, DMBA, or both for 14 weeks. Number of tumors per cheek, volume, histological condition, erbB expression were determined and results were analyzed by the Mann–Whitney U and Dunn’s test. Results: Control groups and those exposed to alcohol (A, B and C respectively) only presented clinical and histological normal mucosa; while those exposed to DMBA or DMBA plus alcohol (D and E groups) developed dysplasia and invasive carcinomas. erbB2, erbB3, and erbB4 increased their expression in alcohol-exposed mucosa, dysplasia, and invasive carcinomas. We observed a similar expression level for erbB2 in dysplasia and carcinomas; while, erbB3 and erbB4 were similar only in carcinomas. Conclusion: The DMBA and alcohol can be considered as carcinogen and promoter for oral carcinogenesis. TheerbB expression is different according to their histological condition, suggesting differential participation of theerbB family in oral carcinogenesis induced by alcohol and DMBA (AU)


Assuntos
Humanos , Genes erbB/genética , Testes de Carcinogenicidade/métodos , Neoplasias/genética , Etanol/análise , 9,10-Dimetil-1,2-benzantraceno/análise , Neoplasias de Células Escamosas/patologia , Tumor Odontogênico Escamoso/patologia
7.
Rev. senol. patol. mamar. (Ed. impr.) ; 19(4): 173-177, oct.-dic. 2006. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-63330

RESUMO

Objetive: ErbB Receptor Tyrosine Kinases possess an establishedrole in mammary gland development and breast tumorigenesis.We aimed to assess the expression of c-erbB3and c-erbB4 RTKs in early breast carcinomas and investigateits possible correlation with Estrogen or Progesterone Receptors,tumor stage and grade, disease recurrence and patient’soutcome.Patients and methods: Forty-nine specimens of earlybreast carcinomas deriving from patients that had sustainedpartial or total mastectomy with axillary lymph node resectionwere studied retrospectively. Expression of RTKs was detectedimplementing: a) an anti-HER-3 mouse polyclonal antibody;and b) an anti-HER-4 mouse polyclonal antibody. For both cerbB3and c-erbB4, either a cytoplasmic or a nuclear stainingpattern of tumor cells was considered positive.Results: Expression of c-erbB4 exhibited statistically significantassociation with tumor grade and unfavorable patient’soutcome. C-erbB3 expression did not correlate with tumorrecurrence or patient’s outcome.No association was established between the expression ofboth RTKs and that of Estrogen or Progesterone Receptors.C-erbB4 expression did not posess statistically significant associationwith patient’s death or disease recurrence. C-erbB3 expressiondid not correlate with tumor grade or recurrence andpatient’s death.Conclusions: In the context of compound molecularmechanisms, alterations in c-erbB3 and c-erbB4 expressionmerit appraisal as future interventions in breast cancer treatmen (AU)


No disponible


Assuntos
Humanos , Feminino , Neoplasias da Mama/patologia , Proteínas Oncogênicas v-erbB/análise , Mastectomia , Genes erbB/genética , Imuno-Histoquímica/métodos , Intervalo Livre de Doença , Progressão da Doença
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA