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5.
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 37(9): 592-601, nov. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-189577

RESUMO

Los últimos avances en el microbioma vaginal y el diagnóstico molecular de la vaginosis bacteriana han permitido un mayor conocimiento de esta entidad caracterizando aspectos de su patogenia y el establecimiento de la biocapa vaginal, los modelos y nuevas teorías de la etiología de la misma, cómo se transmite al considerarse hoy como una probable infección de transmisión sexual, la separación de otras entidades como la vaginitis aerobia, el diagnóstico molecular de la misma y el tratamiento y nuevas moléculas que eviten las recaídas frecuentes. Esta entidad y el estudio del microbioma vaginal han permitido considerar estas infecciones como un síndrome polimicrobiano acabando con el dogma: un microorganismo, una enfermedad. Además, se actualiza una entidad menos conocida como es la vaginitis aerobia y los métodos para su detección


The latest advances in the vaginal microbiome and molecular diagnosis of bacterial vaginosis have allowed for a better knowledge of this entity, characterising aspects of its pathogenesis and the establishment of the vaginal biolayer, the models and new theories of its aetiology, how it is transmitted, with it being considered nowadays as a probable sexually transmitted infection, the separation of other entities such as aerobic vaginosis, its molecular diagnosis and treatment with new molecules to prevent frequent relapses. This entity and the study of the vaginal microbiome have made it possible to consider these infections as a polymicrobial syndrome, putting an end to the dogma: one microorganism, one disease. In addition, a lesser-known entity such as aerobic vaginosis and the methods for its detection are updated


Assuntos
Humanos , Feminino , Vaginose Bacteriana/microbiologia , Microbiota , Vaginose Bacteriana/tratamento farmacológico , Vaginose Bacteriana/epidemiologia , Vagina/microbiologia , Vaginose Bacteriana/diagnóstico , Fatores de Risco , Descarga Vaginal/microbiologia
6.
Rev. esp. quimioter ; 32(5): 426-431, oct. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-188708

RESUMO

INTRODUCCIÓN: La colecistitis constituye una importante causa de ingreso hospitalario. En colecistitis moderada o severa, el retraso en el tratamiento puede acarrear complicaciones graves. Nuestro objetivo es analizar los microorganismos aislados en bilis de pacientes colecistectomizados y su patrón de sensibilidad para evaluar el tratamiento empírico en aquellos casos en que la extirpación quirúrgica de la vesícula deba demorarse. PACIENTES Y MÉTODOS: Estudio descriptivo prospectivo de los cultivos biliares de pacientes sometidos a colecistectomía desde mayo de 2013 hasta febrero de 2015, en el Servicio de Cirugía del Hospital General Universitario de Castellón. RESULTADOS: Se estudiaron 196 pacientes, 83 mujeres (42,3%) y 113 hombres (57,7%), con una media de edad de 61,5 años. Los antibióticos más utilizados como tratamiento empírico fueron piperacilina/tazobactam (77,8%) y amoxicilina/clavulánico (14,8%). En el 46,4% de los pacientes (91/196) los cultivos de bilis fueron positivos. Se aislaron un total de 165 microorganismos. La mayoría eran bacilos gramnegativos (60,5%), principalmente Enterobacterales (91/54,5%), siendo Escherichia coli el microorganismo más frecuente (24%) seguido de Klebsiella spp. (12,5%). Se aislaron 3 E. coli productoras de betalactamasa de espectro extendido (BLEE) y 1 Klebsiella pneumoniae BLEE. No se aislaron microorganismos productores de carbapenemasa ni Staphylococcus aureus resistente a meticilina. CONCLUSIÓN: La microbiota biliar, con predominio de Enterobacterales, es similar a la encontrada en estudios europeos


INTRODUCTION: Cholecystitis is an important cause of hospital admission. In moderate or severe cholecystitis, the delay in treatment can lead to serious complications. Our objective is to analyze the microorganisms isolated in bile from cholecystectomized patients and their sensitivity pattern, to evaluate the empirical treatment in those cases in which the surgical removal of the gallbladder should be delayed. PATIENTS AND METHODS: Prospective descriptive study of biliary cultures of patients undergoing cholecystectomy from May 2013 to February 2015, in the Surgery Department of the Hospital General Universitari de Castelló. RESULTS: We studied 196 patients, 83 women (42.3%) and 113 men (57.7%), with an average age of 61.5 years. The most used antibiotics as empiric treatment were piperacillin/tazobactam (77.8%) and amoxicillin/clavulanic (14.8%). In 46.4% of patients (91/196) bile cultures were positive.165 microorganisms were isolated. The majority were Gram-negative bacilli (60.5%), mainly of the Enterobacterales order (91/54.5%), with Escherichia coli being the most frequent microorganism (24%) followed by Klebsiella spp. (12.5%).3 E. coli with extended-spectrum beta-lactamase (ESBL) and 1 K. pneumoniae with ESBL were isolated. Microorganisms producing carbapenemase and methicillin-resistant Staphylococcus aureus were not isolated. CONCLUSION: The bile microbiota, with a predominance of Enterobacterales is similar to that found in european studies


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Bile/microbiologia , Colecistectomia , Colecistite/microbiologia , Microbiota , Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico , Colecistite/cirurgia , Ciprofloxacino/uso terapêutico , Escherichia coli/isolamento & purificação , Bactérias Gram-Negativas/isolamento & purificação , Klebsiella/isolamento & purificação , Metronidazol/uso terapêutico , Testes de Sensibilidade Microbiana , Combinação Piperacilina e Tazobactam/uso terapêutico , Estudos Prospectivos
7.
Int. microbiol ; 22(3): 297-304, sept. 2019.
Artigo em Inglês | IBECS | ID: ibc-184836

RESUMO

People spend a lot of time indoors and the indoor microbiome is a major part of the environment that we are exposed to. However, awareness of the exposure to the indoor microbiome and its health effects remains poor. Outdoor environment (soil and air), indoor sources (ventilation, dampness and building materials), human occupants, and pets compose the indoor microbial community. It has been estimated that up to 500-1000 different species can be present in house dust. House dust is a major source and reservoir of indoor microbiome, which influences human microbiome and determines health and disease. Herein, we review the origins and the components of the fungal and bacterial communities in house dust and their possible effect on human health, in particular on allergic disorders, intestinal microbiome, and immune responses. We expect to lay a solid foundation for the further study on the mechanisms of how the house dust microbes interact with the host microbiome and the human immune system


No disponible


Assuntos
Humanos , Bactérias/isolamento & purificação , Poeira , Microbiologia Ambiental , Fungos/isolamento & purificação , Microbiota , Medição de Risco , Bactérias/classificação , Fungos/classificação
8.
Int. microbiol ; 22(3): 305-316, sept. 2019. ilus, graf, tab
Artigo em Inglês | IBECS | ID: ibc-184837

RESUMO

Effluents from petroleum refineries contain a toxic mixture of sulfide, nitrogen, and phenolic compounds that require adequate treatment for their removal. Biological denitrification processes are a cost-effective option for the treatment of these effluents, but the knowledge on the microbial interactions in simultaneous sulfide and phenol oxidation in denitrifying reactors is still very limited. In this work, microbial community structure and macrostructure of granular biomass were studied in three denitrifying reactors treating a mixture of inorganic (sulfide) and organic (p-cresol) electron donors for their simultaneous removal. The differences in the available substrates resulted in different community assemblies that supported high removal efficiencies, indicating the community adaptation capacity to the fluctuating compositions of industrial effluents. The three reactors were dominated by nitrate reducing and denitrifying bacteria where Thiobacillus spp. were the prevalent denitrifying organisms. The toxicity and lack of adequate substrates caused the endogenous decay of the biomass, leading to release of organic matter that maintained a diverse although not very abundant group of heterotrophs. The endogenous digestion of the granules caused the degradation of its macrostructure, which should be considered to further develop the denitrification process in sulfur-based granular reactors for treatment of industrial wastewater with toxic compounds


No disponible


Assuntos
Águas Residuárias/microbiologia , Desnitrificação , Microbiota , Sulfetos/metabolismo , Cresóis/química , Bactérias/metabolismo , Indústria de Petróleo e Gás , Ciclo do Nitrogênio , Sulfetos/química , Nitratos/química , Thiobacillus/isolamento & purificação , Biomassa
10.
Nutr. hosp ; 36(extr.3): 40-43, jul. 2019.
Artigo em Espanhol | IBECS | ID: ibc-184433

RESUMO

Numerosos estudios relacionan el hábito de desayunar en niños y adolescentes con una mejor calidad de la dieta y mayor ingesta de nutrientes en general, menor adiposidad y riesgo cardiometabólico, lo que pone de relieve el importante papel de esa comida. Uno de los criterios empleados para definir un desayuno de calidad es la inclusión de, al menos, cereales, lácteos y frutas. Sin embargo, el desayuno más frecuente de los escolares españoles combina solo un lácteo y un cereal. Por lo tanto, sería deseable incorporar fruta en esta primera comida del día, lo que ayudaría, además, a mejorar el bajo consumo en general de fruta de los niños españoles. Por otro lado, el yogur es un alimento de elevada densidad nutricional y su consumo habitual en niños se asocia con una mayor ingesta de la mayoría de nutrientes, con el seguimiento de dietas más equilibradas y con menor prevalencia de sobrepeso y obesidad. Incorporar yogur al desayuno puede ayudar a mejorar la ingesta de algunos de los nutrientes que se toman de forma insuficiente en la dieta y puede servir de vehículo para incorporar otros alimentos, como las frutas. La combinación de estos dos alimentos en una misma comida tiene un efecto sinérgico, tanto al complementarse los nutrientes de cada uno de estos alimentos, como por el efecto sinbiótico que se alcanza al sumar el efecto probiótico del yogur y el prebiótico de la fibra de las frutas


Some studies link children and adolescents breakfast habits with a better quality of the diet and higher intake of nutrients in general, and lower adiposity and cardiometabolic risk, which highlights the important role of this meal. A quality breakfast should include at least three food groups: cereals, dairy and fruits. However, the most frequent breakfast of Spanish schoolchildren combines only dairy and cereals. Therefore, it would be desirable to incorporate fruit in this first meal of the day, which would also help to improve the overall low consumption of fruit by Spanish children. On the other hand, yogurt is a food of high nutritional density and its habitual consumption in children is aßociated with a greater intake of most nutrients, with the follow-up of more balanced diets and with a lower prevalence of overweight and obesity. Incorporating yogurt into breakfast can help to improve the intake of some of the nutrients that are insufficiently in the diet, and can be a vehicle to incorporate other foods such as fruits. The combination of these two foods in the same meal has a synergistic effect, both by complementing the nutrients of each of these foods, and by the synbiotic effect that is achieved by adding the probiotic effect of yogurt and the prebiotic fiber of the fruits


Assuntos
Pré-Escolar , Criança , Adolescente , Desjejum/fisiologia , Iogurte , Dieta Saudável , Nutrientes/administração & dosagem , Frutas , Microbiota
12.
Gastroenterol. hepatol. (Ed. impr.) ; 42(5): 316-325, mayo 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-183782

RESUMO

La asociación entre enfermedad inflamatoria intestinal y colangitis esclerosante primaria debe ser considerada una entidad distinta. Su asociación involucra alteraciones genéticas, epidemiológicas (mayor frecuencia en varones y sin una clara distribución geográfica) y un cuadro clínico en el que destaca con mayor frecuencia un compromiso inflamatorio subclínico, el predominio de colon derecho (demostrado por endoscopia e histología), la presencia de ileítis por reflujo y la ausencia de compromiso rectal. A su vez, existe un mayor riesgo de cáncer de colon y colangiocarcinoma. El objetivo de esta revisión es mostrar como la enfermedad inflamatoria intestinal influye en su evolución, en los requerimientos de trasplante y en la recurrencia. A su vez, señalar la evidencia actual sobre el uso de la terapia biológica en este grupo de pacientes


The association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern) and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients


Assuntos
Humanos , Colangite Esclerosante/complicações , Colangite Esclerosante/epidemiologia , Doenças Inflamatórias Intestinais/epidemiologia , Doenças Inflamatórias Intestinais/etiologia , Recidiva , Doença de Crohn/complicações , Colite Ulcerativa/complicações , Colite Ulcerativa/diagnóstico , Microbiota
13.
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 37(3): 167-171, mar. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-181300

RESUMO

Introduction: New massive sequencing techniques make it possible to determine the composition of airway microbiota in patients with cystic fibrosis (CF). However, the relationship between the composition of lung microbiome and the clinical status of paediatric patients is still not fully understood. Material and methods: A cross-sectional observational study was conducted on induced sputum samples from children with CF and known mutation in the CFTR gene. The bacterial sequences of the 16SrRNA gene were analyzed and their association with various clinical variables studied. Results: Analysis of the 13 samples obtained showed a core microbiome made up of Staphylococcus spp., Streptococcus spp., Rothia spp., Gemella spp. and Granulicatella spp., with a small number of Pseudomonas spp. The cluster of patients with less biodiversity were found to exhibit a greater number of sequences of Staphylococcus spp., mainly Staphylococcus aureus (p 0.009) and a greater degree of lung damage. Conclusion: An airway microbiome with greater biodiversity may be an indicator of less pronounced disease progression, in which case new therapeutic interventions that prevent reduction in non-pathogenic species of the airway microbiota should be studied


Introducción: Las nuevas técnicas de secuenciación masiva permiten determinar la composición de la microbiota de las vías respiratorias en pacientes con fibrosis quística (FQ). Sin embargo, la relación entre la composición de la microbiota pulmonar y el estado clínico de los pacientes pediátricos todavía no se ha establecido bien. Material y métodos: Se realizó un estudio transversal observacional en muestras de esputo inducido de niños con FQ y mutación conocida en el gen CFTR. Se analizaron las secuencias bacterianas del gen 16SrRNA y se estudió su asociación con diversas variables clínicas. Resultados: El análisis de las 13 muestras obtenidas mostró un microbioma central compuesto por Staphylococcus spp., Streptococcus spp., Rothia spp., Gemella spp. y Granulicatella spp., con un pequeño número de Pseudomonas spp. Se descubrió que el grupo de pacientes con menos biodiversidad mostraba un mayor número de secuencias de Staphylococcus spp., principalmente Staphylococcus aureus (p 0,009) y un mayor daño de la función pulmonar. Conclusión: La mayor biodiversidad del microbioma de vía respiratoria puede ser un indicador de menor progresión de la enfermedad, en cuyo caso deben estudiarse nuevas intervenciones terapéuticas que prevengan la disminución de especies no patógenas


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Fibrose Cística/diagnóstico , Fibrose Cística/microbiologia , Microbiota/efeitos dos fármacos , Sistema Respiratório/microbiologia , Escarro/microbiologia , Micobioma , Estudos Transversais , Pulmão/microbiologia
14.
Int. microbiol ; 22(1): 1-6, mar. 2019. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-184808

RESUMO

Between 150 and 200 species of plants, insects, birds or mammals go extinct every day. We do not have any idea what the global extinction rate for microorganisms is. What is clear is that we have already lost a maximum number of the microbes that used to live in and on our skins. Many of our microbial partners are facing extinction as we apply selection pressures that are unprecedented in our long-standing relationships. Recent estimates are that we have lost at least one third of the diversity of our skin microbiome. Every day, most of us bath or shower in water that contains chlorine or fluorine; these additives do a great job of killing pathogenic microbes, but they are probably not helping our skin microbiome. Most of the people apply cosmetic products every day, as these products contain preservatives that prevent microbial growth on the shelf. These same chemicals may well kill microbes on the skin. The daily use of high-pH soaps probably will not help microbial life that is adapted to living on the skin's natural pH of 5. The rise in the rate of C-section births from around 5% in 1970 to more than 30% today is likely to be a contributing factor. Vaginal microbes seed our skins at birth and C-sections disrupt this process. The overuse of broad-spectrum antibiotics has contributed to the loss of our microbial partners in all body sites and the skin is no exception. It is now clear that skin is an ecosystem that is dependent on commensal microbes for optimal health. In general, a diverse ecosystem is a healthy ecosystem that is robust in the face of change. Low-diversity ecosystems are more fragile and susceptible to dysbiosis. Eczema and acne rates have increased rapidly over the last 50 years. These diseases are almost unknown in hunter-gatherer communities. Now, we face two exciting challenges: finding out which species matter and how to get them back


No disponible


Assuntos
Humanos , Micobioma , Pele/microbiologia , Disbiose/microbiologia , Bactérias/efeitos dos fármacos , Microbiota/efeitos dos fármacos , Simbiose , Extinção Biológica , Cosméticos/efeitos adversos , Compostos Químicos/efeitos adversos , Fenômenos Microbiológicos
17.
Allergol. immunopatol ; 47(1): 79-84, ene.-feb. 2019.
Artigo em Inglês | IBECS | ID: ibc-180776

RESUMO

Tremendous progress in the ability to identify and test the function of microorganisms in recent years has led to a much better understanding of the role of environmental and host microbiome in the development of immune function, allergic sensitization and asthma. In this review, the most recent findings on the relationships between environmental microbiota, respiratory, intestinal microbiome, the consequences of early-life microbial exposure type and gut-lung microbial axis and the development of asthma and atopy are summarized. The current perspective on gut and airway microbiome manipulation for the primary prevention of allergic diseases and asthma is also discussed


No disponible


Assuntos
Humanos , Asma/microbiologia , Hipersensibilidade/microbiologia , Intestinos/microbiologia , Pulmão/microbiologia , Exposição Ambiental , Intestinos/imunologia , Pulmão/imunologia , Microbiota , Prevenção Primária
18.
Rev. neurol. (Ed. impr.) ; 68(3): 111-117, 1 feb., 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-177242

RESUMO

Introducción. Se denomina microbiota al conjunto de millones de microorganismos que conviven de manera simbiótica en nuestro organismo. Este conjunto bacteriano, que se localiza principalmente en el tracto digestivo, se distribuye a lo largo de los diferentes órganos en función de las propiedades químicas. Los factores que influyen en su composición son múltiples (dieta, hábitos individuales, fármacos). La microbiota colabora en varias funciones, como pueden ser el metabolismo o la inmunidad. Desarrollo. En los últimos años se ha puesto de relieve el papel bidireccional de la microbiota del tracto digestivo y del sistema nervioso central, es el denominado eje intestino-cerebro. En lo que a este eje se refiere, se cree que la comunicación se produce a través de tres vías: el nervio vago, la vía sistémica (mediante la liberación de hormonas, metabolitos y neurotransmisores) y el sistema inmune (por la acción de las citocinas). Conclusiones. Aunque aún quedan muchas incógnitas por esclarecer, este eje se postula como una posible base patógena para numerosos trastornos neurológicos de gran impacto sanitario, como la enfermedad de Alzheimer, la enfermedad de Parkinson o la esclerosis múltiple. En el momento actual se están llevando a cabo estudios que intentan evaluar el impacto de los probióticos sobre algunas de estas enfermedades neurológicas


Introduction. The microbiota is the set of millions of microorganisms that coexist in a symbiotic way in our body. It is mainly located in the digestive tract, being distributed in function of the chemical properties and the functions of the different organs. The factors that influence its composition are multiple (diet, individual habits, diseases or drugs). It also participates in several functions of the organism such as metabolism, immunity or even the function of the central nervous system. Development. This last interrelationship is called: gut-brain axis. For years the relationship between the microbiota and the central nervous system has been known and how they influence one over the other. It is postulated that communication occurs through three systems: the vagus nerve, the systemic pathway (with the release of hormones, metabolites and neurotransmitters) and the immune system (by the action of cytokines). Conclusions. There are still many unknowns to be clarified in this field, but this microbiota-intestine-brain relationship is postulated as a possible pathogenic basis for neurological diseases of great health impact such as Alzheimer, Parkinson or multiple sclerosis. There are currently studies with probiotics with hopeful results in patients with Alzheimer's disease


Assuntos
Humanos , Microbioma Gastrointestinal , Encéfalo/fisiologia , Probióticos , Sistema Nervoso Central/fisiologia , Sistema Imunitário , Neurotransmissores , Microbiota , Trato Gastrointestinal/fisiologia
19.
Med. clín (Ed. impr.) ; 152(4): 147-153, feb. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-181883

RESUMO

En los últimos años se ha producido una revolución en torno al papel de la microbiota en diferentes enfermedades, la mayoría dentro del espectro de las inflamatorias y autoinmunes, asociado al desarrollo de la metagenómica y al concepto de holobionte, entendido como el conjunto formado por los organismos superiores y su microbiota. Concretamente, en la esclerosis múltiple, existe múltiple evidencia acerca del papel de la microbiota en la encefalomielitis autoinmune experimental, modelo animal de la enfermedad y se han publicado en los últimos años diversos artículos acerca de las diferencias en la microbiota intestinal entre pacientes enfermos de esclerosis múltiple y sujetos control. En este artículo revisamos el concepto de holobionte y las funciones de la microbiota dentro del mismo, así como la evidencia acumulada en el papel de la microbiota en la encefalomielitis autoinmune experimental y en la esclerosis múltiple. A día de hoy, existe una amplia evidencia científica del papel de la microbiota en la génesis, prevención y tratamiento de la encefalomielitis autoinmune experimental en base fundamentalmente a tres pilares inmunológicos, el equilibrio Th1-Th17/Th2, las células Treg y la inmunidad humoral. Así mismo está bien documentado que existen diferencias en la microbiota de pacientes con EM que se asocian a una diferente expresión de genes relacionados con la inflamación


In recent years there has been a revolution regarding the role of the microbiota in different diseases, most of them within the spectrum of inflammatory and autoimmune diseases, associated with the development of metagenomics and the concept of holobiont, a large organism together with its microbiota. Specifically, in Multiple Sclerosis, multiple evidence points to the role of the microbiota in experimental autoimmune encephalomyelitis, animal model of the disease, and several articles have been published in recent years about differences in intestinal microbiota among patients with multiple sclerosis and control subjects. We review in this article the concept of holobiont and the gut microbiota functions, as well as the evidence accumulated about the role of the microbiota in experimental autoimmune encephalomyelitis and multiple sclerosis. Nowadays, there is a lot of evidence showing the role of the microbiota in the genesis, prevention and treatment of experimental autoimmune encephalomyelitis based mainly on three immunological pillars, the Th1-Th17 / Th2 balance, the Treg cells and the humoral immunity. It is also well documented that there are differences in the microbiota of patients with MS that are associated with a different expression of genes related to inflammation


Assuntos
Humanos , Microbiota , Esclerose Múltipla/epidemiologia , Esclerose Múltipla/genética , Encefalomielite Autoimune Experimental , Microbioma Gastrointestinal , Micobioma , Estudos de Casos e Controles , Doenças Autoimunes
20.
Prog. obstet. ginecol. (Ed. impr.) ; 62(1): 72-78, ene.-feb. 2019. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-184899

RESUMO

It is estimated that abnormal vaginal discharge cannot be attributed to a clear infectious etiology in 15% to 50% of cases. Some women develop chronic vulvovaginal problems that are difficult to diagnose and treat, even by specialists. These disorders (aerobic vaginitis, desquamative inflammatory vaginitis, atrophic vaginitis, and cytolytic vaginosis) pose real challenges for clinical diagnosis and treatment. Researchers have established a diagnostic score based on phase-contrast microscopy. We review reported evidence on these entities and present our diagnostic experience based on the correlation with Gram stain. We recommend treatment with an antibiotic that has a very low minimum inhibitory concentration against lactobacilli and is effective against enterobacteria and Gram-positive cocci, which are responsible for these entities (aerobic vaginitis and desquamative inflammatory vaginitis)


Se estima que entre el 15 y el 50% de las mujeres que tienen trastornos del flujo vaginal, éstos no pueden atribuirse a una etiología infecciosa clara. Algunas de ellas desarrollarán problemas vulvovaginales crónicos difíciles de diagnosticar y tratar, incluso por especialistas. Son trastornos que plantean desafíos reales en el diagnóstico clínico y en su tratamiento como la vaginitis aeróbica, la vaginitis inflamatoria descamativa, la vaginitis atrófica y la vaginitis citolítica. Para diagnosticarlos, algunos investigadores han establecido una puntuación basada en la observación microscópica mediante contraste de fases. En este artículo, se revisa la evidencia publicada sobre estas entidades y presentamos nuestra experiencia en la correlación diagnóstica con la tinción de Gram. Se recomienda el tratamiento con un antibiótico con una concentración mínima inhibitoria muy baja contra los lactobacilos y eficaz contra las enterobacterias y los cocos grampositivos, responsables de estas entidades (vaginitis aeróbica y vaginitis inflamatoria descamativa)


Assuntos
Humanos , Feminino , Infecções do Sistema Genital/diagnóstico , Vaginite/classificação , Vaginose Bacteriana/microbiologia , Vaginite Atrófica/diagnóstico , Antibacterianos/uso terapêutico , Microbiota
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