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1.
Allergol. immunopatol ; 48(1): 34-41, ene.-feb. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-186589

RESUMO

Background: Exposure to pets can be a predisposing factor in the development of certain diseases, including allergic diseases. Objective: We analyzed the role that exposure to indoor dogs and cats plays in the prevalence of allergic diseases. Methods: We examined the cross-sectional data of 1056 women and 936 men aged 15 to 18 years; these individuals were selected through stratified and cluster random sampling. We asked all participants about their exposure to indoor dogs and cats during the year that preceded our study. The prevalence of allergic diseases was determined through core questions taken from The International Study of Asthma and Allergies in Childhood questionnaire. Results: The prevalence was 12.7% (95% CI: 11.3%-14.2%) for asthma, 9.0% (95% CI: 7.8%-10.4%) for allergic rhinitis, and 5.2% (95% CI: 4.3%-6.2%) for atopic dermatitis. The multivariate analyses showed that exposure to indoor dogs, but not indoor cats, was associated with asthma prevalence (aOR 1.37; 95% CI: 1.03-1.83), as was male sex (aOR = 1.42; 95% CI: 1.08-1.86), a personal history of allergic rhinitis (aOR = 3.24; 95% CI: 2.25-4.66), and a maternal history of asthma (aOR = 3.06; 95% CI: 1.89-4.98). The population attributable risk for exposure to indoor dogs was 18%. Notably, neither allergic rhinitis nor atopic dermatitis was found to be associated with dog or cat exposure (p > 0.05). Conclusion: Exposure to dogs in late adolescence is a factor associated with asthma, although its contribution to the development of asthma should be investigated in new studies


No disponible


Assuntos
Humanos , Masculino , Feminino , Adolescente , Animais de Estimação , Asma/epidemiologia , Asma/etiologia , Rinite Alérgica/epidemiologia , Dermatite Atópica/epidemiologia , Exposição Ambiental , Cães , Estudos Transversais , Alergia e Imunologia , Análise Multivariada , Inquéritos e Questionários , Estudantes/estatística & dados numéricos , Razão de Chances , Modelos Logísticos
9.
Acta pediatr. esp ; 76(3/4): e33-e40, mar.-abr. 2018. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-177395

RESUMO

La salud y la enfermedad están influenciadas en diferentes etapas de la vida por una combinación de factores genéticos, epigenéticos y ambientales. Está bien documentado que durante el desarrollo temprano la respuesta a diversos estímulos puede programar el riesgo de enfermedades no transmisibles (ENT). Los 1.000 días entre el embarazo y el segundo año de edad son un periodo de oportunidad único, ya que es cuando se establecen los fundamentos de la salud, el crecimiento y el neurodesarrollo para toda la vida. La nutrición temprana ejerce, tanto a corto como a largo plazo, el efecto sobre la salud mediante la programación inmunológica y metabólica y el desarrollo microbiológico. La interacción huésped-microbiota parece influir sobre el riesgo de desarrollar una enfermedad atópica. Por otra parte, la nutrición es especialmente importante para el desarrollo de habilidades cognitivas, motoras y socioemocionales, y mejora el rendimiento escolar y los ingresos económicos en el adulto. La desnutrición durante el embarazo afecta al crecimiento fetal, es un factor determinante del retraso del crecimiento y puede acarrear consecuencias, como la obesidad y las ENT. Existen suficientes evidencias que sugieren que la lactancia materna es un factor protector contra la obesidad y las ENT en la edad adulta, y la intervención precoz sobre la alimentación en los lactantes tendrá una influencia relevante sobre las preferencias alimentarias posteriores. En conclusión, una buena nutrición en los primeros 1.000 días de vida tendrá una influencia muy beneficiosa para la salud posterior. Optimizar el crecimiento prenatal y posnatal temprano es esencial desde el punto de vista preventivo


Patterns of health and disease are influenced at different stage of the life course by a combination of genetic, epigenetic, and environmental factors. It is well-documented that during early development response to a range of stimuli are likely to program the risk of non-communicable diseases. The 1.000 days between pregnancy and a child’s 2nd birthday is a unique period of opportunity when the foundations of optimum health, growth, and neurodevelopment across the lifespam are established. Early nutrition exerts both short- and long-term effect on health of the host by programming immunological, metabolic, and microbiological development. Host-microbe interaction appears to affect the risk of developing atopic disease. Moreover, nutrition is especially important for the developed of cognitive, motor and socio-emotional skills, and improves school achievement and earnings. Undernutrition during pregnancy affecting fetal growth is a major determinant of stunting and can lead to consequences such as obesity and non-communicable diseases. A growing body of evidence suggests that breastfeeding has protective roles against obesity and non-communicable diseases during adulthood, and early influences on feeding practices in infants have a relevant role on later food preferences. In conclusion, better nutrition in de first 1,000 days of live are of major importance for later health. Optimizing prenatal and early growth is essential from preventive point of view


Assuntos
Humanos , Pré-Escolar , Nutrição do Lactente , Desenvolvimento Infantil/fisiologia , Fórmulas Infantis , Alergia e Imunologia , Hipersensibilidade/prevenção & controle , Sobrepeso , Obesidade , Aleitamento Materno , Transtornos da Nutrição Infantil/dietoterapia , Transtornos da Nutrição do Lactente/dietoterapia
10.
Pharm. pract. (Granada, Internet) ; 16(1): 0-0, ene.-mar. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-171850

RESUMO

Objective: Characterization of the adverse drug reactions (ADR) reported by the immunoallergology department (IAD), Centro Hospitalar de São João (Porto), to the Northern Pharmacovigilance Centre (NPC). Methods: An observational, descriptive and retrospective study was conducted, based in a spontaneous report system. Participants were all the patients from the IAD, with suspected ADR, reported to NPC by specialists after the study was completed. Results: Studied population had a median age of 41 years, with the predominance of the female gender (73.2%). Allergic rhinitis and asthma were the most frequent comorbidities. All studied ADR were type B, 89.6% were serious, 86.4% unexpected and 2.6% associated with drugs that presented less than 2 years in the market. The most represented drug classes were the non-steroidal anti-inflammatory drugs (NSAIDs) (52.6%) and antibiotics (25.2%). Skin symptoms represented 61.2% of the reported complaints. About 52.9% of these ADR occurred in less than one hour after intake. The most frequent ADR treatment at the time of the reaction was drug interruption (86.2%), followed by the prescription of anti-histamines (42.2%). Conclusions: Reported ADR to NPC by the Drug Alert Unitwere mainly serious, unexpected, associated with NSAIDs and antibiotics and related with marketing authorization medicines older than two years. These results could be very useful to develop strategiesto prevent the clinical and economic consequences of ADR (AU)


No disponible


Assuntos
Humanos , Hipersensibilidade a Drogas/epidemiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Alergia e Imunologia/estatística & dados numéricos , Unidades Hospitalares/estatística & dados numéricos , Estudos Retrospectivos , Sistemas de Notificação de Reações Adversas a Medicamentos/estatística & dados numéricos
11.
Actas dermo-sifiliogr. (Ed. impr.) ; 109(2): 162-172, mar. 2018. graf, ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-172389

RESUMO

Introducción: Los tatuajes se han convertido en una práctica muy popular en los países occidentales, sobre todo entre los más jóvenes. Las complicaciones asociadas a esta técnica incluyen procesos infecciosos, alérgicos, reacciones a cuerpo extraño e incluso procesos inflamatorios sistémicos. Pacientes y métodos: Se ha realizado un estudio retrospectivo de todos los pacientes que acudieron a la consulta de Alergia cutánea por manifestar complicaciones en un tatuaje desde enero de 2002 a diciembre de 2016. Resultados: Se han incluido a 23 pacientes. De ellos, 9 presentaron complicaciones de forma precoz y en todos ellos la etiología fue infecciosa. De los 14 pacientes con reacciones tardías, 10 fueron diagnosticados de probable dermatitis de contacto alérgica a la tinta, sin embargo solo en 3 de los casos se pudo apuntar al alérgeno probablemente culpable y tan solo en uno de ellos se pudo demostrar. Se detectaron dos casos de sarcoidosis cutánea, uno de reacción granulomatosa a cuerpo extraño, y un caso de reacción neuropática en una paciente. Conclusiones: Las complicaciones asociadas a los tatuajes son un motivo de consulta relativamente frecuente en las consultas de Dermatología. Proponemos un algoritmo diagnóstico basado en nuestra casuística, que ayude a orientar las distintas reacciones a tatuaje y con ello a iniciar las medidas terapéuticas oportunas (AU)


Introduction: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses. Patients and methods: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Results: We studied 23 patients. Nine of these experienced early complications, all related to infection. The other 14 patients developed late reactions. Ten were diagnosed with probable allergic contact dermatitis to ink, but the suspect allergen was identified in just 3 cases and confirmed in just 1 of these. There were 2 cases of cutaneous sarcoidosis, 1 case of foreign body granuloma, and 1 case of neuropathy. Conclusions: Complications resulting from tattoos are relatively common dermatology complaints. Drawing from our experience, we propose a diagnostic algorithm designed to guide dermatologists in evaluating different reactions to tattoos and prescribing appropriate treatment (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Tatuagem/efeitos adversos , Hipersensibilidade/complicações , Hipersensibilidade/diagnóstico , Hipersensibilidade/terapia , Tatuagem/normas , Tatuagem/tendências , Hipersensibilidade/etiologia , Hipersensibilidade/prevenção & controle , Alergia e Imunologia/tendências
14.
An. sist. sanit. Navar ; 40(2): 269-278, mayo-ago. 2017. tab
Artigo em Espanhol | IBECS | ID: ibc-165876

RESUMO

La introducción de procedimientos diagnósticos y terapéuticos que implican exposición alergénica conlleva riesgos. Para evaluar la seguridad clínica en las unidades de Alergología de la Comunidad Valenciana se diseñó y distribuyó un cuestionario anónimo, obteniendo respuesta de doce unidades hospitalarias y ocho centros de especialidades. La distribución de prestaciones entre los diversos entornos fue homogénea, así como la utilización de unidades de críticos, urgencias u hospitales de día para técnicas de mayor riesgo. La dotación de instrumentos relacionados con la seguridad es más amplia en las consultas hospitalarias e incluye fuente de oxígeno (91,7%), pulsioxímetro (75,0%) o monitor (8,3%), carro de paradas (91,7%) y desfibrilador (83,33%). El tiempo de respuesta para emergencias está pactado en el 50%. Sistemáticamente se revisa el material para resucitación y se firma consentimiento informado. La seguridad es más limitada en los centros de especialidades. Se deberían establecer las condiciones idóneas de seguridad clínica en Alergología (AU)


The introduction of new diagnostic and therapeutic procedures involving allergen exposure may increase the risk of allergic reactions. We designed and distributed an anonymous questionnaire among the allergy units of the Valencian Community in order to collect information on measures to ensure clinical safety. Twelve hospital outpatient clinics and 8 ambulatory care centres reported similar patterns of activities, including the use of critical care units, emergency rooms or day hospitals for higher risk techniques. The provision of security-related instruments is broader in hospital outpatient clinics and included: oxygen (91.7%), pulse oximeter (75.0%) or vital signs monitor (8.3%), resuscitation material (91.7%) and defibrillator (83.3%). The response time for emergencies is set in 50% of clinics. The resuscitation material is systematically reviewed and informed consent signed. Security is more limited in ambulatory care centres. It is necessary to set down the conditions for clinical safety in allergology (AU)


Assuntos
Humanos , Gestão da Segurança/organização & administração , Segurança do Paciente/normas , Unidades Hospitalares/organização & administração , Assistência Ambulatorial/métodos , Ambulatório Hospitalar/organização & administração , Alergia e Imunologia/organização & administração , Alergia e Imunologia/normas , Serviços de Saúde/normas , Serviços de Saúde/tendências
16.
An. pediatr. (2003. Ed. impr.) ; 86(2): 99.1-99.9, feb. 2017. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-159750

RESUMO

La sospecha de alergia a antibióticos betalactámicos, especialmente penicilina y sobre todo amoxicilina, suponen el motivo de consulta más frecuente en las Unidades de Alergia Infantil. En este documento de consenso se describe la clínica y los criterios diagnósticos de las reacciones alérgicas, así como el tratamiento antibiótico alternativo de las infecciones más habituales en pediatría, para los pacientes con sospecha diagnóstica o confirmación de la alergia (AU)


The suspected allergy to beta-lactam antibiotics, especially penicillin and amoxicillin, is the most frequent reason for consultation in Child Allergy Units. In this consensus document, the clinical and diagnostic criteria of allergic reactions are described, as well as alternative antibiotic treatment for the most common infections diagnosed in paediatrics for patients with known or suspected allergy (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Conferências de Consenso como Assunto , Sociedades Médicas/normas , Sociedades Médicas , Alergia e Imunologia/organização & administração , Alergia e Imunologia/normas , Hipersensibilidade a Drogas/epidemiologia , Hipersensibilidade a Drogas/prevenção & controle , Infecções/tratamento farmacológico , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/prevenção & controle , Resistência beta-Lactâmica , beta-Lactamas/efeitos adversos , Serviços de Saúde Comunitária , Infecções Urinárias/epidemiologia
17.
J. investig. allergol. clin. immunol ; 27(4): 204-212, 2017. tab
Artigo em Inglês | IBECS | ID: ibc-165009

RESUMO

Regulatory B (Breg) cells are recognized as immunosuppressive cells. During the last few years, several subsets of Breg cells with different phenotypes and suppressive mechanisms have been described in the literature. We review the role of Breg cells in allergy based on an extensive literature search in PubMed. We describe the types and mechanisms of action of B cells and their role in the pathogenesis of several allergic diseases (allergic asthma, allergic rhinitis, food allergy, contact hypersensitivity, and anaphylaxis) (AU)


Los linfocitos reguladores del tipo B (B reg.) juegan un papel importante en el funcionamiento del sistema inmunitario. Durante los últimos años, se han descrito varios subgrupos de linfocitos B reg., con diferentes fenotipos y mecanismos supresores. Nuestro objetivo es recopilar la información existente sobre el papel de los linfocitos B reg. en Alergología, en base a una profunda investigación bibliográfica en PubMed. Describimos los tipos y mecanismos de acción de los linfocitos B y su función en la patogénesis de varias enfermedades alérgicas (asma alérgica, rinitis alérgica, alergia alimentaria, eccema de contacto y anafilaxia) (AU)


Assuntos
Humanos , Feminino , Gravidez , Linfócitos B Reguladores/imunologia , Linfócitos B Reguladores/metabolismo , Sistema Imunitário/metabolismo , Sistema Imunitário/fisiopatologia , Alergia e Imunologia/normas , Alérgenos/imunologia , Asma/patologia , Rinite/patologia , Hipersensibilidade Alimentar/patologia , Dermatite Atópica/patologia , Anafilaxia/patologia
20.
J. investig. allergol. clin. immunol ; 27(supl.1): 1-35, 2017. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-167145

RESUMO

Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations. A systematic search of MEDLINE, Cochrane, and Clinical Trials databases from 2000 to April of 2016 was carried out by a panel of experts from the Spanish Allergy and Clinical Immunology Scientific Society. Relevant studies prior to the year 2000 included in ulterior systematic reviews were also considered. More than 4000 articles were identified during the search and 241 were selected to retrieve available evidence on AIT, which was graded according to the Oxford classification. All the group members reviewed the resulting text until the final version reached the consensual agreement. A summary of recommendations on the more relevant topics are proposed. The role of AIT as a valuable therapeutic strategy for prevention of exacerbation and progressive decline in lung function is highlighted. Future research should include specific tools for asthma evaluation when assessing AIT effectiveness in asthmatic patients (AU)


El asma se asocia frecuentemente con alergia, entendida ésta como la producción de IgE específica frente a alérgenos ambientales. Actualmente, existen dos tipos de inmunoterapia específica con alérgenos (ITE) para la práctica clínica habitual: subcutánea y sublingual, ambas indicadas en el tratamiento de la rinitis y la conjuntivitis alérgicas. Sin embargo, su papel en el asma resulta todavía controvertido. Este documento pretende ofrecer al clínico una revisión de la evidencia del uso de ITE en asma, centrándose en aspectos más relevantes como su mecanismo de acción, eficacia, seguridad, tolerabilidad y coste-eficacia, tanto en población adulta como pediátrica. Un panel de expertos de la Sociedad Española de Alergología e Inmunología Clínica, llevó a cabo una búsqueda sistemática en las bases de datos MEDLINE, Cochrane y Clinica Trials, desde 2000 a abril de 2016. También se revisaron algunos estudios anteriores al 2000, incluidos en revisiones sistemáticas posteriores. Se identificaron más de 4000 artículos en la búsqueda y se seleccionaron 241 para documentar la evidencia disponible y graduarla según la clasificación Oxford. Todos los miembros del panel revisaron el texto resultante hasta la versión final, alcanzando un acuerdo de consenso y se propusieron recomendaciones para los aspectos más relevantes. Se señala específicamente que la ITE resulta potencialmente valorable en la prevención de las exacerbaciones y el declive progresivo de la función pulmonar, aunque se necesitan nuevos estudios que incluyan variables específicas de evaluación de asma para verificar la eficacia de la ITE en esta patología (AU)


Assuntos
Humanos , Criança , Adulto , Asma/terapia , Dessensibilização Imunológica/métodos , Conferências de Consenso como Assunto , Técnicas Imunológicas/métodos , Alérgenos/imunologia , Hipersensibilidade/imunologia , Resultado do Tratamento , Análise Custo-Benefício/métodos , Imunoterapia/classificação , Alergia e Imunologia , Alergia e Imunologia/normas , Biomarcadores/análise , Administração Sublingual , Infusões Subcutâneas , Alérgenos/administração & dosagem , Asma/economia
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