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1.
Med. oral patol. oral cir. bucal (Internet) ; 20(4): e427-e434, jul. 2015. ilus
Artigo em Inglês | IBECS | ID: ibc-138969

RESUMO

Background: To determine the toxicity of aqueous dilutions of a universal self-priming dental adhesive (DA) and comparing these with those elicited by exposure to ionizing radiation (IR), Zoledronic acid (Z) treatment and the synergic effects of the combined treatment with IR+Z. Material and Methods: The genotoxic effect of DA was determined by the increase in the frequency of micronuclei in cytokinesis-blocked in cultured human lymphocytes before and after exposure to 2Gy of X-rays. The cytotoxic effect was studied by using the MTT cell viability test in normal prostate cell lines (PNT2) after exposure to different X-ray doses (0Gy-20Gy). The cell lines divided into different groups and treated with different test substances: DA in presence of O2 , DA in absence of O2 , Z-treated and control. Results: An in vitro dose-dependent and time-dependent cytotoxic effect of DA, Z and IR on PNT2 cells (p>0.001) was demonstrated. DA without-O2, following the recommendations of manufacturers, had a more pronounced effect of increasing cell death than DA with-O2 (p<0.001). In the genotoxicity assay, DA at 25% of its original concentration significantly increased chromosome damage (p<0.001). The samples studied were found to be toxic, and the samples photo-polymerized in absence of O2 showed a bigger cytotoxic effect comparable to the additive toxic effect showed by the combined treatment of IR+Z. Conclusions: Additional effort should be carried out to develop adhesives, which would reduce the release of hazardous substances; since toxic effects are similar to that reported by other agents whose clinical use is controlled by the health authorities (AU)


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Assuntos
Cimentos Dentários/toxicidade , Radiometria/métodos , Radiação Ionizante , Sinergismo Farmacológico , Genotoxicidade/análise , Transformação Celular Neoplásica/patologia , Técnicas In Vitro , Exposição à Radiação , Exposição a Produtos Químicos , Materiais Dentários/toxicidade , Usos Especializados de Substâncias Químicas , Testes para Micronúcleos , Classificação e Identificação por Risco de Substâncias, Produtos e Materiais , Raios X , Análise de Variância
2.
Rev. toxicol ; 22(3): 162-168, sept.-dic. 2005. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-66493

RESUMO

Las Organizaciones Internacionales han desarrollado a lo largo de los años normas legales, reglamentarias y administrativas relativas al uso de sustancias peligrosas que permiten la transmisión de la información de prevención y control, mediante etiquetas o fichas de datos de seguridad, a los usuarios de dichos productos químicos. A este respecto, la Unión Europea ha introducido legislación específica diseñada para proteger la salud humana y el medio ambiente. Una correcta clasificación, envasado y etiquetado de los productos químicos es fundamental para identificar los peligros derivados de sus usos. La etiqueta es, a menudo, la única información de los peligros de la que disponen tanto los usuarios como los trabajadores. En materia de sustancias y preparados peligrosos existe legislación europea desde 1967, fecha en que se reconoció que las disposiciones nacionales sobre clasificación, envasado y etiquetado de productos químicos (fundamentalmente productos industriales peligrosos) debían de armonizarse en el seno de la Unión Europea para la prevención y control de los riesgos derivados, y para eliminar las barreras comerciales que podían suponer las disposiciones nacionales en los Estados miembros. El objetivo de este trabajo es presentar una revisión de toda la legislación en la Unión Europea sobre clasificación, envasado y etiquetado de productos químicos y los principios de su evaluación del riesgo


The International Agencies have developed the approximation of laws, regulations and administrative provisions relating to the use of dangerous substances which make possible to transfer information for protecting the public and control these products with requirements concerning labelling and safety data sheets. The European Union has introduced specific legislation designed to protect human health and the environment. A good classification, packaging and labelling of chemical products is basic to identify the hazards of the uses. The labelling is the first and often the only information on the hazards of a chemical that reaches the user, which could be a consumer or a worker. There are european legislation about dangerous susbstances and preparations since 1967, which it was recognized that the national dispositions about classification, packaging and labelling of chemicals should be harmonised in the European Union to prevent and control the risks from chemicals and eliminate barriers. The aim of this paper is to review the current legislation in the European Union on classification, packaging and labelling of chemicals and the principles of their risk assessment


Assuntos
Rotulagem de Produtos/normas , Armazenamento de Substâncias e Resíduos Perigosos , Substâncias Tóxicas , Classificação e Identificação por Toxicidade , Contêineres de Resíduos Perigosos , Derramamento de Materiais Perigosos , Medição de Risco/métodos , Riscos Ambientais , Classificação e Identificação por Risco de Substâncias, Produtos e Materiais
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