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3.
Allergol. immunopatol ; 48(1): 84-89, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186597

RESUMO

Background and objectives: Vitamin D status may be related to allergen sensitizations, but the evidence is inconsistent. The objective of this study was to assess whether serum 25-hydroxyvitamin D (25(OH)D) levels were associated with allergic sensitizations in early childhood. Methods: Data were collected from 2642 children who visited the Guangdong Women and Children's Hospital from January 2016 to May 2017 for routine health check-ups. Serum 25(OH)D levels were tested by electrochemiluminescence immunoassay. Allergic sensitizations including food and inhalant allergens were tested for specific IgE antibodies at one year (12 months 0 days through 12 months 30 days) and two years (24 months 0 days through 24 months 30 days) of age. Results: The mean level of serum 25(OH)D was 86.47 ± 27.55 nmol/L, with a high prevalence of vitamin D insufficiency (< 75 nmol/L) in children aged 0-2 years (36.8%). Lower 25(OH)D levels with serum total IgE of more than 200IU/mL (81.54 ± 25.53 nmol/L) compared with less than 100 IU/mL (87.92 ± 28.05 nmol/L). The common sensitization to allergens in children aged one and two years were milk (44.2%), cat epithelium (26.4%), egg (13.1%), dog epithelium (12.7%) and Dermatophagoides farinae (6.7%). After multivariate adjustment, data in 25(OH)D treated as a continuous variable or categories, no consistent associations were found between 25(OH)D levels and allergen-specific IgEs. Conclusions: Serum 25(OH)D level showed an inverse relationship with total IgE level in early childhood. However, there is lack of evidence to support associations between low 25(OH)D levels and allergic sensitization to various allergens


No disponible


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Vitamina D/análogos & derivados , Imunização/métodos , Imunoglobulina E/sangue , Hipersensibilidade/diagnóstico , Técnicas Imunoenzimáticas , Imunoglobulina E/imunologia , China
4.
Med. clín (Ed. impr.) ; 154(1): 7-12, ene. 2020. mapas, graf, tab
Artigo em Inglês | IBECS | ID: ibc-188677

RESUMO

Background: There is growing evidence that vitamin D is related to the development of a variety of diseases. The current study was performed to investigate the status of serum vitamin D distribution among adult Chinese people and reveal the influence of gender, age, seasonality and residential regions on serum vitamin D levels. Method: This cross-sectional study included 14,302 participants aged from 18 years old to 65 years old from six major cities in China. The basic demographic information and the levels of serum vitamin D (25(OH)D) and vitamin D3 (25(OH)D3) were collected from Jan 2, 2014 to Dec 25, 2017. Result: The prevalence of 25(OH)D3 concentration <30ng/mL reached up to 83%, in which the rate of vitamin D insufficiency (20-29ng/mL) was 32.7%, and vitamin D deficiency (10-19ng/mL) accounted for 41.9%, and vitamin D severe shortage (<10ng/mL) accounted for 8.4%. Women were more likely to have vitamin D3 deficiency and lower serum vitamin D3 concentration than men (both p < 0.001). The mean concentration of serum 25(OH)D and 25(OH)D3 in summer and autumn were higher than that in spring and winter (p < 0.001), and the mean concentration of serum 25(OH)D in people from Southern China was higher than that in people from other regions (p < 0.001). Although the mean concentrations of serum 25(OH)D and 25(OH)D3 were both increased by age, the percentage of patients with serum 25(OH)D3 insufficiency was also increased. Conclusion: Serum vitamin D deficiency is very common in adults in China. The level of serum vitamin D may be associated with age, sex, seasonality and residential regions


Fondo: Una gran cantidad de investigaciones muestran que la vitamina D está relacionada con el desarrollo de una variedad de enfermedades. El presente estudio apunta a investigar el estado de la distribución de la vitamina D sérica entre los adultos chinos, y revelar la influencia del género, la edad, la estacionalidad y las regiones residenciales sobre los niveles séricos de vitamina D. Metodología: El presente estudio transversal incluyó a 14.302 participantes con edades comprendidas entre de 18 y 65 años, provenientes de las 6 principales ciudades de China. Se recogió la información demográfica básica y se analizó la concentración sérica de vitamina D 25(OH)D y vitamina D3 25(OH)D3 del 2 de enero de 2014 al 25 de diciembre de 2017. Resultado: La prevalencia de concentración de 25(OH)D3Y3 y menor concentración sérica de vitamina D3 que los varones (pY3 en verano y otoño era mayor que en primavera e invierno (pY3 aumentaron levemente con la edad, el porcentaje de pacientes con insuficiencia sérica de vitamina D 25(OH)D3 también experimentó un incremento. Conclusión: La deficiencia sérica de vitamina D es muy común en adultos en China. Es probable que el nivel sérico de vitamina D esté asociado a la edad, el sexo, la estacionalidad y las regiones residenciales


Assuntos
Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Deficiência de Vitamina D/epidemiologia , Fatores de Risco , Deficiência de Vitamina D/sangue , Estudos Transversais , China/epidemiologia , Inquéritos e Questionários , Testes Sorológicos/métodos , Modelos Logísticos
5.
Rev. clín. esp. (Ed. impr.) ; 220: 0-0, 2020. mapas, graf
Artigo em Espanhol | IBECS | ID: ibc-187746

RESUMO

ANTECEDENTES Y OBJETIVO: Desde diciembre del 2019, se está detectando en el mundo un incremento de casos de una nueva enfermedad causada por el coronavirus 2019 (COVID-19). El objetivo de este artículo es proporcionar recomendaciones científicas para la prevención y el control de la COVID-19 en todo el mundo. MÉTODOS: Se han recopilado características demográficas generales, antecedentes epidemiológicos y síntomas clínicos de la COVID-19 recogidos en los sitios web de múltiples Comisiones Municipales de Salud en China. Aquí describimos las distribuciones temporales, geográficas y de población de la COVID-19. RESULTADOS: Hasta la medianoche del 10 de febrero del 2020, el número de casos confirmados de COVID-19 en China fue de 42.638, siendo Hubei la provincia con un mayor número de casos confirmados (31.728), seguida por Guangdong (1.177), Zhejiang (1.117) y la provincia de Henan (1.105), en China. El número de casos y la velocidad de confirmación en otras provincias fue más moderada que en la provincia de Hubei. La mediana (rango intecuartílico) de edad de 1.740 pacientes de COVID-19 fue de 44 años (33, 54), con un rango desde los 10 meses a los 89 años. CONCLUSIONES: La epidemia de COVID-19 se ha de considerar como una amenaza mundial, y los pasos encaminados para su control incluyen el diagnóstico temprano y su tratamiento, así como el aislamiento


BACKGROUND AND OBJECTIVE: Since December 2019, increasing cases of novel coronavirus disease 2019 (COVID-19) are being detected worldwide. The purpose of this paper is to provide a scientific reference for the global prevention and control of COVID-19. METHODS: General demographic characteristics, epidemiological history, and clinical symptoms of COVID-19 were collected that had been reported on the websites of multiple Municipal Health Commissions in China. We herein describe distributions in time, place, and population of COVID-19. RESULTS: As of midnight on February 10, 2020, the number of confirmed cases of COVID-19 in China was 42,638, and the province with the largest number of confirmed cases was Hubei (31728), followed by Guangdong (1177), Zhejiang (1117), and Henan (1105) province. The number of cases and the speed of confirmed cases in provinces other than Hubei were more moderate than those of the Hubei province. The median (interquartile range) age of 1740 patients with COVID-19 was 44 (33, 54) years, with a range of 10 months to 89 years. CONCLUSIONS: The COVID-19 epidemic should be considered a global threat and the steps for control include early diagnosis and treatment, as well as isolation


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Infecções por Coronavirus/epidemiologia , Vírus da SARS/patogenicidade , Pneumonia Viral/epidemiologia , Pandemias/estatística & dados numéricos , China/epidemiologia , Distribuição Temporal , Sistemas de Informação Geográfica/organização & administração , Estudos Ecológicos , Ameaças/análise , Isolamento de Pacientes/estatística & dados numéricos , Diagnóstico Precoce
6.
Med. clín (Ed. impr.) ; 153(12): 441-445, dic. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-188453

RESUMO

Background: Moyamoya disease belongs to rare diseases which are arousing public awareness of its importance in China. In order to investigate the clinical features of inpatients diagnosed Moyamoya disease, the study was conducted to collect clinical information data of subjects on demographic information and clinical characteristics in Henan, China. Methods: The data of 198 cases of Moyamoya disease from 56 tertiary hospitals in Henan province from January 2003 to June 2015 were collected retrospectively. Analysis was performed based on demographic, clinical and radiological characteristics of the patients. Results: The mean onset age was 44.03±14.45 years old. Unilateral limb weakness (36.4%) was the most common physical examination. Primary clinical manifestation was headache and dizziness (50.3%). Cranial CT showed cerebral infarction was mainly located in the frontal lobe (27.4%). MRA and DSA showed lesions mainly located in the middle cerebral artery (30.3% and 18.7%). Conclusions: Clinical manifestations of Moyamoya disease varied. Early diagnosis was necessary to reduce the misdiagnosis rate of this disease. Symptoms, radiological characteristics, and lesion localization characteristics should be fully considered, especially for indicators with a certain onset age, headache and dizziness, lesion located in the frontal lobe of middle cerebral artery


Antecedentes: La enfermedad de moyamoya pertenece al grupo de afecciones raras cuya importancia está despertando la conciencia pública en China. Con el fin de investigar las características clínicas de los pacientes hospitalizados en Henan (China) diagnosticados con la enfermedad de moyamoya, se llevó a cabo este estudio para recopilar información clínica sobre los pacientes junto con información demográfica y características clínicas. Métodos: Se recogieron retrospectivamente datos de 198 casos de la enfermedad de moyamoya en 56 hospitales terciarios de la provincia de Henan entre enero de 2003 y junio de 2015. El análisis se realizó con base en las características demográficas, clínicas y radiológicas de los pacientes. Resultados: La edad media de inicio de la enfermedad era de 44,03±14,45 años. La debilidad unilateral de las extremidades (36,4%) fue el hallazgo más común en las exploraciones físicas y la manifestación clínica primaria fue la combinación de dolor de cabeza y mareos (50,3%). La tomografía craneal mostró que el infarto cerebral afectaba principalmente al lóbulo frontal (27,4%). La angiografía de resonancia magnética y la angiografía por sustracción digital mostraron lesiones ubicadas principalmente en la arteria cerebral media (30,3 y 18,7%, respectivamente). Conclusiones: Las manifestaciones clínicas de la enfermedad de moyamoya fueron muy variadas. El diagnóstico precoz resultó necesario para reducir la tasa de diagnósticos erróneos de esta enfermedad. Se deben considerar los síntomas, las características radiológicas y las características de ubicación en su totalidad, especialmente en el caso de indicadores con una edad específica de inicio, dolor de cabeza y mareos, o una lesión situada en el lóbulo frontal, en la arteria cerebral media


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Doença de Moyamoya/epidemiologia , Lobo Frontal/diagnóstico por imagem , Infarto Cerebral/complicações , Estudos Retrospectivos , Debilidade Muscular/complicações , Cefaleia/complicações , Angiografia Cerebral , Diagnóstico Precoce , China , Pressão Sanguínea , Inquéritos e Questionários
7.
Allergol. immunopatol ; 47(1): 85-89, ene.-feb. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-180777

RESUMO

Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. SLIT for three years is suitable for patients to acquire stable therapeutic effects, and the efficacy of single-allergen SLIT for polysensitized patients has also been confirmed. Nevertheless, there are still several factors restricting its application in China, such as the uncertainty of its long-term effects and the prevention of new sensitizations onset, the risk of asthma attacks, the low public awareness of SLIT and poor compliance by patients. This is a narrative review of current evidence on SLIT coming from China


No disponible


Assuntos
Humanos , Animais , Asma/terapia , Imunoterapia Sublingual/métodos , Asma/epidemiologia , Asma/imunologia , China/epidemiologia , Imunoterapia Sublingual/normas , Pyroglyphidae/imunologia , Cooperação do Paciente , Antígenos de Dermatophagoides/imunologia
8.
Rev. psicol. deport ; 28(supl.1): 9-16, 2019. tab
Artigo em Inglês | IBECS | ID: ibc-190215

RESUMO

The aim of this investigation was to explore what are the key factors on Chinese elite basketball player's careers, and understand what facts have helped them to achieve the highest sportive level. The pathway to excellence of three Chinese elite basketball players were analyzed through a semi structured interview with different categories such as Social Context, Sport Context, Tactical Factors or Anthropometric Factors. Results showed that "family tradition", academic studies, coaches, training structuration and international competitions had influenced the talent development of Chinese basketball players


El objetivo de esta investigación fue explorar cuáles son los factores clave en el desarrollo del talento de tres jugadores de baloncesto chinos de élite y comprender qué hechos los han ayudado a alcanzar el nivel deportivo más alto. El camino hacia la excelencia de estos jugadores de baloncesto de élite chinos se analizó a través de una entrevista semiestructurada con diferentes categorías, como contexto social, contexto deportivo, factores tácticos o factores antropométricos. Los resultados mostraron que la "tradición familiar", los estudios académicos, la influencia de los entrenadores, la estructuración de entrenamientos y las competiciones internacionales habían influido en el desarrollo del talento de los jugadores chinos de baloncesto


O objetivo desta pesquisa foi explorar quais são os fatores-chave no desenvolvimento do talento de três jogadores de basquete chineses de elite e entender que fatos os ajudaram a atingir o mais alto nível esportivo. O caminho para a excelencia desses jogadores de basquete chineses de elite foi analisado por meio de uma entrevista semiestruturada com diferentes categorias, como contexto social, contexto esportivo, fatores táticos ou fatores antropométricos. Os resultados mostraram que a "tradição familiar", os estudos acadêmicos, a influência dos treinadores, a estruturação de treinamentos e as competições internacionais influenciaram o desenvolvimento do talento dos jogadores de basquete chineses


Assuntos
Humanos , Basquetebol/fisiologia , Entrevistas como Assunto , 25783 , China
9.
Rev. psicol. deport ; 28(2): 87-96, 2019. tab
Artigo em Inglês | IBECS | ID: ibc-184747

RESUMO

The present study aimed to measure motivation in physical education by the Perceived Locus of Causality Scale (PLOC) within a cross-cultural context. A sample of 2,293 adolescents from China (n = 1,287) and Spain (n = 1,006) completed the scales. The results largely supported the reliability and the validity of PLOC in both cultures as well as its cross-cultural equivalence except three problematic items found in the Chinese sample. Moreover, Chinese adolescents scored higher in intrinsic motivation and identified regulation, and lower in introjected regulation, external regulation, and a motivation than Spanish adolescents. These findings supported the universality of motivation structure across different cultures. However, problematic items encountered in Chinese adolescents and differences in motivation suggest that cultural values may cause adolescents to interpret certain motives differently, which highlighted the importance of cultural adaptation when measuring adolescents' motivation


El presente estudio intentó a medir la motivación en educación física por la Escala de locus de causalidad percibido (PLOC) dentro un contexto transcultural. En total 2,293 adolescentes de China (n = 1,287) y de España (n = 1,006) completaron las escalas. Se apoyan la fiabilidad y la validez de PLOC y su equivalencia transcultural excepto tres ítems problemáticos encontrado en la muestra china. Además, los adolescentes chinos obtuvieron puntuaciones más altas en motivación intrínseca, regulación identificada, y puntuaciones más bajas en regulación introyectada, regulación externa y amotivación que los españoles. Los resultados indican transculturalmente una estructura universal de motivación. Sin embargo, los ítems problemáticos en la muestra china y las diferencias de motivación sugieren que los valores culturales afectan la interpretación de unos motivos de los adolescentes, que destaca la importancia de adaptación cultural a medir la motivación de los adolescentes


O presente estudo teve como objetivo mensurar motivação na educação física pelo Escala do locus de causalidade percibido (PLOC) dentro de um contexto transcultural. No total, 2.293 adolescentes da China (n = 1.287) e da Espanha (n = 1.006) completaram as escalas. Os resultados apoiaram amplamente a confiabilidade e validade do PLOC em ambas as culturas, ebm como sua equivalência transcultural, exceto por três itens problemáticos encontrados na amostra chinesa. Além disso, os adolescentes chineses pontuaram mai em motivação intrínseca, regulação identificada, e menor em regulação introjetada, regulação externa e amotivação do que os adolescentes espanhóis. Essas descobertas apoiaram a universalidade da estrutura de motivação. No entanto, os itens problemáticos encontrados em adolescentes chineses e as diferenças na motivação sugerem que os valores culturais podem levar os adolescentes a interpretar certos motivos de maneira diferente, o que destacou a importância da adaptação cultural ao medir motivação dos adolescentes


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Motivação , Educação Física e Treinamento , Causalidade , Espanha , China , Psicometria , Características Culturais , Inquéritos e Questionários , Reprodutibilidade dos Testes
10.
J. investig. allergol. clin. immunol ; 28(6): 407-413, 2018. tab
Artigo em Inglês | IBECS | ID: ibc-174554

RESUMO

Background: Asthma is a complex and heterogeneous disease. We found gene-gene interactions between IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 in asthmatic Chinese Han children. This 4-locus set constituted an optimal statistical interaction model. Objective: We examined associations between the 4-gene model (IL13, IL4, FCER1B, and ADRB2) and the Asthma Predictive Index (API) and atopy in Chinese Han children. Methods: Four single-nucleotide polymorphisms in the 4 genes were genotyped in 385 preschool children with wheezing symptoms using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The t test and x2 tests were used for the analysis. Results: Significant correlations were found between the 4-locus gene model and a stringent and loose API (both P<.0001). Additionally, a high-risk asthma genotype was a risk factor for a positive API (stringent API, OR=4.08; loose API, OR=2.36). We also found a statistically significant association between the 4-locus gene model and atopy (P<.01, OR=2.09). Conclusions: Our results indicated that the 4-locus gene model consisting of L13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 was associated with the API and atopy. These findings provide evidence that this gene model can be used to determine a high risk of developing asthma and atopy in Chinese Han children


Antecedentes: El asma es una enfermedad compleja y heterogénea. En este estudio, encontramos que las interacciones gen-gen entre IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713 y FCER1B rs569108, en niños asmáticos de nacionalidad china Han, constituyen un modelo estadístico óptimo de interacción. Objetivo: Este estudio examinó un modelo de las asociaciones de cuatro genes (IL13, IL4, FCER1B y ADRB2) con el Índice Predictivo de Asma (IPA) y la atopia en niños Han chinos. Métodos: Se genotiparon cuatro polimorfismos de un solo nucleótido (SNP) en los cuatro genes, en 385 niños en edad preescolar con síntomas de sibilancias, utilizando espectrometría de masas con desorción/ionización mediante láser asistida por Matriz (MALDI). Para el análisis estadístico de utilizaron el test t de Student y el c2. Resultados: Se encontraron correlaciones significativas entre el modelo génico de los cuatro locus y el valor de IPA estricto y laxo (ambos P <0,0001). Además, el genotipo de riesgo alto de asma fue un factor de riesgo para IPA positivo (IPA estricto: OR = 4,08, IPA laxo: OR = 2,36). También, encontramos una asociación estadísticamente significativa entre el modelo génico de los cuatro locus, con atopia (P <0,01, OR = 2,09). Conclusiones: Nuestros resultados indicaron que el modelo génico de cuatro locus compuesto por L13 rs20541, IL4 rs2243250, ADRB2 rs1042713 y FCER1B rs569108 estaba asociado con IPA y atopia. Estos hallazgos proporcionan la evidencia de la utilidad de este modelo génico para determinar el riesgo alto de desarrollar asma y atopia en niños chinos Han


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Asma/epidemiologia , Hipersensibilidade Imediata/epidemiologia , Loci Gênicos/genética , Interleucina-4/genética , Interleucina-13/genética , Receptores Adrenérgicos beta/genética , Fragmentos Fc das Imunoglobulinas/genética , China/epidemiologia , Marcadores Genéticos , Predisposição Genética para Doença/genética , Modelos Genéticos , Polimorfismo de Nucleotídeo Único/genética
11.
Span. j. psychol ; 21: e65.1-e65.11, 2018. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-189180

RESUMO

Teachers are burdened by high work pressure, suggesting the need for an effective stress coping system to support them. The present study evaluated the effectiveness of coping strategies currently utilized by teachers and explored the potential contribution of group sandplay to coping. The study was led by a group of experienced therapists and sandplay practitioners. Two hundred teachers served as participants, equally divided into two groups: An experimental sandplay group (EG) and control group. Both groups received a 3-hour tutorial on the psychological pressure at work, reactions to it, and physical/mental symptoms resulting from overwhelming pressure, and were introduced to the working principles and process of sandplay. EG participants then engaged in group sandplay for three consecutive days. The Simplified Coping Style Questionnaire was used as an objective measure of participants' coping styles. Therapists' and practitioners' observations were used as subjective information, including the scenes and themes created by participants, individual performance during sandplay activities, and feedback regarding changes to stress coping strategies. We compared participants' pre-and post-test stress coping strategies. The results revealed a significant improvement in the EG sample at the shift from passive coping (pre-test M = 1.94, 95% CI [1.83-2.05]; post-test M = 0.96, 95% CI [0.92-1.00]) to active coping (pre-test M = 1.76, 95% CI [1.69-1.83]; post-test M = 2.41, 95% CI [2.29-2.53]). Overall, our findings support the conclusion that group sandplay effectively improved Chinese teachers' overall stress coping abilities


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Adaptação Psicológica , Esgotamento Profissional/reabilitação , Ludoterapia/métodos , Professores Escolares/psicologia , China , Resultado do Tratamento
12.
Allergol. immunopatol ; 45(6): 541-548, nov.-dic. 2017. tab, graf
Artigo em Inglês | IBECS | ID: ibc-168461

RESUMO

Background: The aim of the current study is to evaluate the prevalence, severity and possible risk factors of systemic reactions (SRs) to subcutaneous allergen immunotherapy (SCIT) in children and adolescents with asthma in Hangzhou, east China's Zhejiang province. Methods: From January 2011 to December 2016, this survey analysed the SCIT-related SRs involving 429 patients (265 children and 134 adolescents) affected by allergic asthma. Recorded data included demographics, diagnosis, patient statuses, pulmonary function testing results before and after each injection, allergen dosage, and details of SRs. Results: All patients finished the initial phase and six patients withdrew during the maintenance phase. There were 2.59% (328/12,655) SRs in all injections (3.28% in children and 1.47% in adolescents); 15.62% (67/429) patients experienced SRs (18.49% children and 10.98% adolescents). There were 54.57% SRs of grade 1; 42.37% SRs of grade 2; 3.05% SRs of grade 3; and no grades 4 or grade 5 SRs occurred in patients. Most reactions were mild, and were readily controlled by immediate emergency treatment. There was no need for hospitalisation. The occurrence of SRs was significantly higher in children than that in adolescents (p < 0.01). A higher ratio of SRs was found among patients with moderate asthma. Conclusion: This retrospective survey showed that properly-conducted SCIT was a safe treatment for children and adolescents with asthma in Hangzhou, East China. Children and patients with moderate asthma may be prone to develop SRs (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adolescente , Imunoterapia/métodos , Hipersensibilidade/terapia , Asma/terapia , Dessensibilização Imunológica/métodos , Infusões Subcutâneas , China/epidemiologia , Estudos Retrospectivos , Dermatophagoides pteronyssinus/patogenicidade , Testes Cutâneos
13.
Allergol. immunopatol ; 45(5): 432-438, sept.-oct. 2017. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-166996

RESUMO

Objective: To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children. Methods: 572 adolescent asthma patients and 590 age-matched healthy controls were included in this study. A total of four SNPs were genotyped, including rs2241715 of TGFB1, rs2378383 of TLE4, rs2523924 of MUC22, and rs907092 of IKZF3. Allele frequencies of the patients and the control group were compared by the Chi-square test. The Student t test was used to analyse the relationship between genotypes and clinical feature of the patients. Results: Patients were found to have significantly different frequencies of allele A of rs2241715, allele G of rs2378383 and allele A of rs2523924 as compared with the controls (40.4% vs. 45.9%, p = 0.01 for rs2241715; 17.2% vs. 13.4%, p=0.01 for rs2378383; 15.3% vs. 11.9%, p = 0.02 for rs2523924). For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG (59.1 ± 4.3% vs. 55.4 ± 3.7%, p < 0.001). Moreover, those with genotype GG/GA of rs2378383 had remarkably lower FEV1% as compared with those with genotype AA (54.6 seg ± 2.9% vs. 58.6 ± 4.1%, p < 0.001). Conclusions: Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population. Our results associating TGFB1 and TLE4 with clinical features of asthma suggest potential application of these parameters in the management of asthma children (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Polimorfismo Genético , Asma/genética , China/epidemiologia , Fator de Crescimento Transformador beta1/genética , Predisposição Genética para Doença/genética , Fatores de Risco
14.
Med. clín (Ed. impr.) ; 148(10): 444-448, mayo 2017. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-162723

RESUMO

Objetivo: Estudiar los parámetros de EZSCAN como herramienta de cribado de la diabetes en la población china. Métodos: En el estudio participaron 6.270 sujetos. A todos ellos se les realizó la prueba EZSCAN, la prueba de fasting plasma glucose (FPG, «glucosa plasmática en ayunas»), el test de tolerancia oral de la glucosa y HbA1c. Resultados: 1. Se dividió a los sujetos en 4 grupos: el grupo normal, el grupo de riesgo bajo, formado por sujetos con anomalías metabólicas del azúcar, el grupo de riesgo medio y el grupo de alto riesgo. La diferencia en cuanto a incidencia de diabetes entre los 4 grupos fue estadísticamente significativa. Con el incremento de la puntuación EZSCAN, la prevalencia de diabetes se incrementó significativamente. Pero no se produjo diferencia estadísticamente significativa entre el grupo de bajo riesgo y el de riesgo medio. 2. Tras ajustar otras variables, se produjo una relación significativamente positiva entre la puntuación de riesgo EZSCAN y el riesgo de diabetes, mientras que no se produjo una diferencia estadísticamente significativa entre el grupo de bajo riesgo y el de riesgo medio. 3. El punto de corte de EZSCAN para la diabetes fue del 44,5%, con una sensibilidad del 73,2%, que fue superior a FPG y HbA1c. Conclusión:A medida que aumenta la puntuación de riesgo de diabetes EZSCAN, se incrementa el riesgo de la enfermedad. EZSCAN puede utilizarse como herramienta de cribado de la diabetes. Con un valor de punto de corte para el cribado de la diabetes del 44,5%, la sensibilidad es superior a la de los métodos tradicionales FPG y HbA1c (AU)


Objective: To study the parameters of EZSCAN as a screening tool for diabetes in Chinese. Methods: A total of 6,270 subjects participated in the study. All subjects underwent tests of EZSCAN, fasting plasma glucose (FPG), oral glucose tolerance test and HbA1c. Results: 1. All subjects were divided into 4 groups: the normal group, sugar metabolic abnormalities as low-risk group, middle-risk group and high-risk group. The difference of diabetes incidence among the 4 groups was statistically significant. With the increase of EZSCAN score, the prevalence of diabetes increased significantly. But there is no statistically difference between the low-risk group and the middle-risk group. 2. After adjustment for other variables, there is significantly positive relationship among EZSCAN risk score and the risk of diabetes. Meanwhile there is no statistically difference between the low-risk group and the middle-risk group. 3. The cut-off point of EZSCAN for diabetes was 44.5% with the sensitivity was 73.2% which was higher than of FPG and HbA1c. Conclusion: As EZSCAN-diabetes risk score increases, the risk of diabetes increases. EZSCAN can be used as a tool for screening for diabetes. At the best screening diabetes cut-off point value 44.5%, the sensitivity is higher than traditional method of FPG and HbA1c (AU)


Assuntos
Humanos , Índice Glicêmico , Diabetes Mellitus/diagnóstico , Programas de Rastreamento/métodos , Iontoforese/instrumentação , China/epidemiologia , Glicemia/análise , Diabetes Mellitus/epidemiologia , Reprodutibilidade dos Testes , Pesos e Medidas Corporais/estatística & dados numéricos , Sensibilidade e Especificidade
15.
Med. oral patol. oral cir. bucal (Internet) ; 22(2): e219-e227, mar. 2017. graf, tab, ilus
Artigo em Inglês | IBECS | ID: ibc-161240

RESUMO

Background: Genome wide association studies (GWAS) already have identified tens of susceptible loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, whether these loci associated with nonsyndromic cleft palate only (NSCPO) remains unknown. Material and Methods: In this study, we replicated 38 SNPs (Single nucleotide polymorphisms) which has the most significant p values in published GWASs, genotyping by using SNPscan among 144 NSCPO trios from Western Han Chinese. We performed the transmission disequilibrium test (TDT) on individual SNPs and gene-gene (GxG) interaction analyses on the family data; Parent-of-Origin effects were assessed by separately considering transmissions from heterozygous fathers versus heterozygous mothers to affected offspring. Results: Allelic TDT results showed that T allele at rs742071 (PAX7) (p=0.025, ORtransmission=3.00, 95%CI: 1.09- 8.25) and G allele at rs2485893 (10kb 3’ of SYT14) were associated with NSCPO (p=0.0036, ORtransmission= 0.60, 95%CI: 0.42-0.85). Genotypic TDT based on 3 pseudo controls further confirmed that rs742071 (p-value=0.03, ORtransmission=3.00, 95%CI: 1.09-8.25) and rs2485893 were associated with NSCPO under additive model (p-value= 0.02, ORtransmission= 0.66, 95%CI: 0.47-0.92). Genotypic TDT for epistatic interactions showed that rs4844913 (37kb 3’ of DIEXF) interacted with rs11119388 (SYT14) (p-value=1.80E-08) and rs6072081 (53kb 3’ of MAFB) interacted with rs6102085 (33kb 3’ of MAFB) (p-value=3.60E-04) for NSCPO, suggesting they may act in the same pathway in the etiology of NSCPO. Conclusions: In this study, we found that rs742071 and rs2485893 were associated NSCPO from Han Chinese population; also, interactions of rs4844913:rs11119388 and rs6072081:rs6102085 for NSCPO were identified, genegene interactions have been proposed as a potential source of the remaining heritability, these findings provided new insights of the previous GWAS (AU)


No disponible


Assuntos
Humanos , Estudo de Associação Genômica Ampla/métodos , Fissura Palatina/genética , Fenda Labial/genética , China , Polimorfismo de Nucleotídeo Único/genética , Técnicas de Genotipagem/métodos , Epistasia Genética/genética
16.
Nutr. hosp ; 34(1): 175-179, ene.-feb. 2017. tab
Artigo em Inglês | IBECS | ID: ibc-161158

RESUMO

Background: To investigate the species of zoonotic trematodes and the endemic infection status in the domestic animals in Huainan areas, north Anhui province of China, we intent to provide evidences for prevention of the parasitic zoonoses. Methods: The livestock and poultry (definitive hosts) were purchased from the farmers living in the water areas, including South Luohe, Yaohe, Jiaogang and Gaotang Lakes, and dissected the viscera of these collected hosts to obtain the parasitic samples. Then the specimens were microscopically identified, with reference to the descriptions in previous literatures for counting the zoonotic species found in these areas. Results: A total of 41 species were detected in the domestic samples, in which 23 were zoonotic trematodes, and 18 were internal trematodes of animals. Of the 41 species, 38 were novel records in Huainan areas, and 12 were newly detected in Anhui province, including Metorchis anatinus, Echinostoma hortense, E. cinetorchis, E. angustitestis, E. lindoensis, E. nordiana, E. ilocanum, Metagonimus yokogawai, Prosthogonimus gracilis, P. skrjabini, P. anatinus and Trichobilharzia sp. which generally occurred in definitive hosts of chicken, ducks, geese, dogs, cattle, buffaloes, sheep, goats and pigs, respectively. Conclusion: A large quantity of livestock and poultry are fed by the local farmers living along the river banks in Huainan area, suggesting that the population in that area are at higher risks of natural focus of zoonotic infections, since these animals are favorable definitive hosts to the zoonotic trematodes (AU)


Introducción: para investigar las especies de trematodos zoonóticos y el estado de infección endémica en los animales domésticos en áreas de Huainan, al norte de la provincia de Anhui, China, tenemos la intención de proporcionar evidencias para la prevención de enfermedades zoonóticas. Métodos: el ganado y las aves (hospedadores definitivos) fueron adquiridos a los campesinos que viven en las zonas con agua, incluyendo el sur de Luohe, Yaohe, Jiaogang y Gaotang Lagos, y se diseccionaron las vísceras de estos anfitriones recogidos para obtener las muestras parasitarias. Las muestras fueron identificadas microscópicamente, con referencia a las descripciones de la literatura revisada para contar las especies zoonóticas que se encuentran en estas áreas. Resultados: se detectaron un total de 41 especies en las muestras nacionales, de las que 23 eran trematodos zoonóticos y 18 eran trematodos internos de los animales. Estas especies representaron 22 géneros en 12 familias de 4 órdenes. De las 41 especies, 38 fueron registros nuevos en las áreas de Huainan y 12 fueron detectadas recientemente en la provincia de Anhui, incluyendo Metorchis anatinus, Echinostoma hortense, E. cinetorchis, E. angustitestis, E. lindoensis, E. nordiana, Euparyphium ilocanum, Metagonimus yokogawai, Prosthogonimus gracilis, P. skrjabini, P. anatinus y Trichobilharzia sp., generalmente producidos en huéspedes definitivos de pollo, patos, gansos, perros, vacas, búfalos, ovejas, cabras y cerdos, respectivamente. Conclusión: los agricultores locales que viven a lo largo de las orillas del río se alimentan de gran cantidad de ganado y aves de corral de la zona de Huainan, lo que sugiere que la población en esa área tiene mayor riesgo ante el foco natural de las infecciones zoonóticas, ya que estos animales son huéspedes definitivos favorables a los trematodos zoonóticos (AU)


Assuntos
Humanos , Trematódeos/isolamento & purificação , Infecções por Trematódeos/microbiologia , Enteropatias Parasitárias/epidemiologia , Zoonoses , Doenças das Aves/microbiologia , Doenças dos Bovinos/microbiologia , Fatores de Risco , China/epidemiologia
17.
Med. oral patol. oral cir. bucal (Internet) ; 22(1): e115-e121, ene. 2017. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-159776

RESUMO

Background: Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) is a leading cause of death in cancer patients. The aim of this study was to explore the potential risk factor of VTE in oral and maxillofacial oncological surgery. Material and Methods: The data of patients who received operation in our institution were gathered in this retrospective study. A diagnosis of VTE was screened and confirmed by computer tomography angiography (CTA) of pulmonary artery or ultrasonography examination of lower extremity. Medical history and all perioperative details were analyzed. Results: 14 patients were diagnosed as VTE, including 6 cases of PE, 7 cases of DVT, 1case of DVT and PE. The mean age of these patients was 62.07 years. Reconstruction was performed in 12 patients of these cases, most of which were diagnosed as malignance. Mean length of surgery was 8.74 hours, and lower extremity deep venous cannula (DVC) was performed in all these patients. Conclusions: We analyzed several characters of oral and maxillofacial surgery and suggested pay attention to lower extremity DVC which had a high correlation with DVT according to our data (AU)


No disponible


Assuntos
Humanos , Tromboembolia Venosa/epidemiologia , Neoplasias Bucais/cirurgia , Procedimentos Cirúrgicos Bucais/estatística & dados numéricos , Neoplasias Maxilares/cirurgia , Complicações Pós-Operatórias/epidemiologia , China/epidemiologia , Embolia Pulmonar/epidemiologia , Trombose Venosa/epidemiologia
18.
Rev. psicol. deport ; 26(supl.4): 110-114, 2017. tab
Artigo em Inglês | IBECS | ID: ibc-165298

RESUMO

Physical inactivity is becoming increasingly prevalent in Chinese university students. This study aims to assess the leisure-time physical activity level of the Chinese university students and to examine the correlation between the physical activity level and the self-efficacy to overcome barriers to physical activity. Five hundred and thirty Chinese university students participated in the study voluntarily. The International Physical Activity Questionnaire (IPAQ, Chinese Short version) and the Self-Efficacy to Overcome Barriers to Physical Activity Scale (SOBPAS) are adopted. The results suggested: (1) the level of leisure-time physical activity in Chinese University students is relatively low; (2) self-efficacy to overcome barriers to physical activity is significantly correlated with the physical activity, it can be used as a predictor of university students’ leisure time physical activity (AU)


La inactividad física es cada vez más frecuente en los estudiantes universitarios chinos. Este estudio tiene como objetivo evaluar el nivel de actividad física de los estudiantes universitarios chinos y examinar la correlación entre el nivel de actividad física y la autoeficacia para superar las barreras a la actividad física. Quinientos treinta estudiantes universitarios chinos participaron voluntariamente en el estudio. Se aprueban el Cuestionario Internacional de Actividad Física (IPAQ, Versión Corta Chino) y la Autoeficacia para Superar Barreras a la Escala de Actividad Física (SOBPAS). Los resultados sugieren: 1) que el nivel de actividad física en los estudiantes universitarios chinos es relativamente bajo; (2) la autoeficacia para superar las barreras a la actividad física está significativamente correlacionada con la actividad física, puede ser utilizado como predictor de la actividad física de los estudiantes universitarios de tiempo libre (AU)


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Autoeficácia , Atividade Motora , China , Estudantes/psicologia , Esportes/psicologia , Exercício Físico/psicologia , Atividades de Lazer
19.
Fontilles, Rev. leprol ; 30(6): 561-562, sept.-dic. 2016.
Artigo em Espanhol | IBECS | ID: ibc-159086
20.
Med. oral patol. oral cir. bucal (Internet) ; 21(6): e737-e742, nov. 2016. tab
Artigo em Inglês | IBECS | ID: ibc-157754

RESUMO

Background: This study investigated the quality of life of Chinese patients with tongue cancer who had undergone immediate flap reconstruction surgery. In addition, we compared 2 groups of patients: those who had received radial forearm free flap (RFFF) surgery and others who had received pectoralis major myocutaneous flap (PMMF) surgery. Material and Methods: Patients who received RFFF or PMMF reconstruction after primary tongue cancer treated with total and subtotal tongue resection were eligible for the current study. The patients' demographic data, medical history, and quality of life scores (14-item Oral Health Impact Profile (OHIP-14) and the University of Washington Quality of Life (UW-QOL) questionnaires) were collected. Results: A total of 41 of 63 questionnaires were returned (65.08%). There were significant differences between the 2 groups in the gender (p< .05). Patients reconstructed with RFFF performed better in the shoulder domains, in addition to worse appearance domains. Conclusions: Using either RFFF or PMMF for reconstruction of defects after tongue cancer resection significantly influences a patient's quality of life. Data from this study provide useful information for physicians and patients during their discussion of reconstruction modalities for tongue cancers (AU)


No disponible


Assuntos
Humanos , Neoplasias da Língua/cirurgia , Retalhos de Tecido Biológico , Retalho Miocutâneo , Procedimentos Cirúrgicos Reconstrutivos/métodos , Qualidade de Vida , Perfil de Impacto da Doença , Nervo Radial/transplante , Nervos Torácicos/transplante , China
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