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1.
Int. j. morphol ; 38(3): 755-760, June 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1098316

RESUMO

SUMMARY: The objective of this study was to describe the effects of monosodium glutamate on the collagen of the parotid gland in an obesity model. 18 newborn male Sprague Dawley rats were used (first control group; second group of MSG1: 4 mg/g of monosodium glutamate weight, 5 doses, and third group of MSG2: 4 mg/g of monosodium glutamate, 5 doses, maintained for 8 and 16 weeks respectively). The content and type of collagen were analyzed, in addition to the levels of cholesterol, glucose, triglycerides and uric acid. Monosodium glutamate produced an increase in the obesity rates of the MSG2 group, in addition to an increase in blood cholesterol, glucose and uric acid levels compared to the control group. Type III collagen in the MSG2 group showed a statistically significant increase. Monosodium glutamate induced obesity, in addition to an increase in type III collagen fibers.


RESUMEN: El objetivo de este estudio fue describir los efectos del glutamato monosódico sobre el colágeno de la glándula parótida en un modelo de obesidad. Se utilizaron 18 ratas Sprague Dawley machos recién nacidas (primer grupo control; segundo grupo MSG1: 4 mg/g de peso de glutamato monosódico, 5 dosis, y tercer grupo MSG2: 4 mg/g de glutamato monosódico, 5 dosis, mantenidas durante 8 y 16 semanas respectivamente). Se analizó el contenido y el tipo de colágeno, además de los niveles de colesterol, glucosa, triglicéridos y ácido úrico. El glutamato monosódico produjo un aumento en las tasas de obesidad del grupo MSG2, además de un aumento en los niveles de colesterol en sangre, glucosa y ácido úrico en comparación con el grupo control. El colágeno tipo III en el grupo MSG2 mostró un aumento estadísticamente significativo. La obesidad inducida por glutamato monosódico, además de un aumento en las fibras de colágeno tipo III.


Assuntos
Animais , Masculino , Ratos , Glândula Parótida , Glutamato de Sódio/toxicidade , Colágeno/efeitos dos fármacos , Obesidade/induzido quimicamente , Glândulas Salivares/efeitos dos fármacos , Triglicerídeos/sangue , Ácido Úrico/sangue , Glicemia/análise , Peso Corporal/efeitos dos fármacos , Colesterol/sangue , Colágeno/análise , Ratos Sprague-Dawley , Modelos Animais de Doenças , Animais Recém-Nascidos
2.
Arch. argent. pediatr ; 117(3): 301-304, jun. 2019. ilus, tab
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1001207

RESUMO

El schwannoma es un tumor benigno originado de las células de Schwann y puede producirse a lo largo de cualquier nervio en el que estas células formen parte de su vaina. Los schwannomas del nervio facial extratemporales son infrecuentes y se presentan como masas indoloras en la región parotídea, de lento crecimiento y con compromiso del nervio facial. Se los debe tener en cuenta como diagnóstico diferencial en masas parotídeas en los niños, aunque sean raros. La utilización de la punción aspirativa con aguja fina y la resonancia magnética nuclear evidencia la mejor aproximación diagnóstica. El tratamiento quirúrgico de elección en la localización intraparotídea es la parotidectomía superficial. Otra opción es la tumorectomía completa con electroestimulación intraoperatoria y preservación del nervio facial. Se presenta un caso de schwannoma intraparotídeo en una paciente pediátrica operada con esta última técnica.


Schwannomas are benign tumors which arise from Schwann cells and take place along peripheral nerves. Extra-temporal facial nerve schwannomas are infrequent and present as painless masses in the parotid region, slow-growing and involvement of the facial nerve. Although rare, they should be taken into account as a differential diagnosis in parotid masses in children. Surgical strategies include superficial parotidectomy and surgical tumor resection with electrical nerve stimulation and nerve preservation. The following case describes a paediatric patient treated with the previously mentioned nerve sparing surgical technique.


Assuntos
Humanos , Feminino , Adolescente , Glândula Parótida , Pediatria , Nervo Facial , Neoplasias , Neurilemoma
3.
Int. j. morphol ; 37(2): 701-705, June 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1002280

RESUMO

The frequent use of animal models in biomedical research means that the anatomy or histology of the animals is constantly analyzed so the results obtained can be extrapolated to human tissues; therefore, knowledge of the structures studied is truly important. This study compares the human parotid gland to that of three animal species from a histological point of view. Five parotid gland samples from each animal species were used: Sprague Dawley rats (Rattus norvegicus), C57BL/6 mice (Mus musculus) and male rabbits (Oryctolagus cuniculus). The samples were stained using H/E, Masson trichrome and van Gieson's techniques. The anatomical relations of the parotid glands in the three species were the facial nerve, master muscle and mandibular ramus among other anatomical elements. Histologically, the duct system in the three species is comprised of intercalated, striated, excretory ducts and main excretory ducts. Human, rodent and rabbit parotid glands are made of purely serous adenomeres. The intercalated and striated ducts are prominent. The human parotid gland is well characterized by intralobular adipose tissue, as is observed in rabbit, whereas the adipocytes are not prominent in the parotid gland in rats and mice. The tissue of the rat parotid gland contained a large number of serous acini that included a large area of gland tissue and few ducts, as observed in the rabbit and human. The glands studied present considerable morphological similarities with the human one that make them reliable candidates as experimental models of parotid tissue.


El frecuente uso de modelo animal en investigación biomédica, hace que constantemente sea analizada la anatomía o histología de dichos animales, donde los resultados obtenidos deben ser extrapolables a tejidos humanos, por lo cual el conocimiento de las estructuras estudiadas, es realmente importante. El presente trabajo compara a la glándula parótida humana con las de tres especies desde un punto de vista histológico. Se utilizaron muestras de glándula parótida de ratas Sprague Dawley (Rattus norvegicus) (n=5), ratones (Mus musculus) cepa C57BL/6 (n=5) y conejos (Oryctolagus cuniculus) (n=5) machos, las cuales fueron teñidas con técnicas de H/E, Tricrómico de Masson y van Gieson. Las glándulas parótidas analizadas se relacionaron anatómicamente en todas las especies con elementos tales como nervio facial, músculo masetero, rama mandibular entre otros. Con respecto a la histología, el sistema de conductos de roedores así como de conejo se compone de conductos intercalados (ID), estriado (SD), excretor (ED) y conductos excretores principales. Las glándulas parótidas humanas, de roedores y conejos están compuestas de adenómeros serosos puros. La ID y SD son prominentes. La glándula parótida humana está bien caracterizada por tejido adiposo intralobular, al igual a lo encontrado en el conejo, mientras que los adipocitos no son prominentes en la glándula parótida en ratas y ratones. El tejido de la glándula parótida de la rata se observaron gran cantidad de acinos serosos que comprenden una gran área del tejido de la glándula y unos pocos conductos, al igual que el conejo y humano. Las glándulas estudiadas presentan semejanzas morfológicas considerables con la humana que las hacen candidatas confiables al momento de su elección como modelos experimentales del tejido parotídeo.


Assuntos
Humanos , Animais , Camundongos , Coelhos , Ratos , Glândula Parótida/anatomia & histologia , Anatomia Comparada , Ratos Sprague-Dawley , Camundongos Endogâmicos C57BL
4.
Int. arch. otorhinolaryngol. (Impr.) ; 23(1): 83-87, Jan.-Mar. 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1002182

RESUMO

Abstract Introduction chronic parotitis (CP) is a hindering, recurring inflammatory ailment that eventually leads to the destruction of the parotid gland. When conservative measures and sialendoscopy fail, parotidectomy can be indicated. Objective to evaluate the efficacy and safety of parotidectomy as a treatment for CP unresponsive to conservative therapy, and to compare superficial and near-total parotidectomy (SP and NTP). Methods retrospective consecutive case series of patients who underwent parotidectomy for CP between January 1999 and May 2012. The primary outcome variables were recurrence, patient contentment, transient and permanent facial nerve palsy and Frey syndrome. The categorical variables were analyzed using the two-sided Fisher exact test. Alongside, an elaborate review of the current literature was conducted. Results a total of 46 parotidectomies were performed on 37 patients with CP. Neartotal parotidectomy was performed in 41 and SP in 5 cases. Eighty-four percent of patients was available for the telephone questionnaire (31 patients, 40 parotidectomies) with a mean follow-up period of 6,2 years. Treatment was successful in 40/46 parotidectomies (87%) and 95% of the patients were content with the result. The incidence of permanent and transient facial nerve palsy was 0 (0%) and 12 (26.1%), respectively. Frey syndrome manifested in 20 (43.5%) patients. Neither this study nor careful review of the current literature resulted in evident difference between SP and NTP regarding the primary outcome variables. Conclusion parotidectomy is a safe and effective treatment for CP in case conservative therapy fails. There is no evidence of a distinct difference between SP and NTP regarding efficiency, facial nerve palsy or Frey syndrome. (AU)


Assuntos
Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Parotidite/cirurgia , Glândula Parótida/cirurgia , Glândula Parótida/fisiopatologia , Parotidite/fisiopatologia , Sialadenite/cirurgia , Sialadenite/fisiopatologia , Procedimentos Cirúrgicos Otorrinolaringológicos , Doença Crônica , Resultado do Tratamento
5.
Rev. odontol. Univ. Cid. São Paulo (Online) ; 31(2): [125-133], abr/jun 2019. il.
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1021708

RESUMO

A glândula parótida é uma glândula salivar maior, que abriga um feixe vasculonervoso e está situada no espaço parotídeo, um arcabouço ósseo e muscular. Ela pode ser avaliada por diferentes exames de imagem, principalmente pela ultrassonografia (USG), a tomografia computadorizada (TC) e a ressonância magnética (RM). Faz-se necessário o conhecimento de sua condição de normalidade para compará-la à de afecção, pois procedimentos cirúrgicos são frequentemente requeridos como meio de tratamento. A maioria dos pesquisadores e profissionais que manejam essa glândula referem a necessidade de estudos mais aprofundados, visto que o conhecimento acerca do assunto é limitado e suas patologias e manejo são pouco explorados e contraditórios na literatura


The parotid gland is a major salivary glands, which houses a neurovascular bundle and is situated in the parotid space, a bone and muscular framework. It can be assessed by different imaging tests, mainly by ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). Is knowledge necessary of its normal condition to compare it to the condition, since surgical procedures are often required as a means of treatment. Most researchers and professionals who handle this gland refer the need for further studies, since knowledge on the subject is limited and its pathologies and management are underexplored


Assuntos
Humanos , Masculino , Feminino , Adulto , Glândula Parótida , Ultrassonografia , Região Parotídea
7.
Odontoestomatol ; 20(31): 78-85, junio de 2018.
Artigo em Inglês, Espanhol | LILACS | ID: biblio-905034

RESUMO

El adenocarcinoma de células basales es una neoplasia epitelial con las características citológicas del adenoma de células basales pero con un patrón morfológico de crecimiento infiltrante indicativo de malignidad. Debido a su baja incidencia es a menudo difícil de diagnosticar. El objetivo del presente estudio fue identificar características morfológicas e inmunohistoquímicas que contribuyen a su diagnóstico. Se resecó un tumor de parótida en una paciente de 52 años; se realizó biopsia postoperatoria e inmunomarcación con Ki-67, CK19, p63 y alfa actina de músculo liso. Se diagnosticó adenocarcinoma de células basales mixto sólido y tubular con invasión perineural y de la cápsula tumoral, grasa periglandular y nodos linfoides. La inmunomarcación con Ki-67, CK19, p63 y alfa actina de músculo liso resultó positiva. Posteriormente se diagnosticó una metástasis en seno maxilar. Las características morfológicas, la inmunomarcación Ki-67 positiva y la metástasis le dan el carácter maligno a este tumor, lo que lo diferencia del adenoma de células basales


Basal cell adenocarcinoma is an epithelial neoplasm with the cytological characteristics of a basal cell adenoma but with a morphological pattern of infiltrative growth indicative of malignancy. It is often difficult to diagnose it because of its low incidence. The objective of this study is to identify the morphological and immunohistochemical characteristics that aid its diagnosis. A parotid tumor was resected in a 52-year-old patient; postoperative biopsy and immunostaining with Ki-67, CK19, p63 and α-smooth muscle actin were performed. The diagnosis was basal cell adenocarcinoma invading the tumor capsule, periglandular fat and lymph nodes. Immunolabeling with Ki-67, CK19, p63 and α-smooth muscle actin was positive. Subsequently, maxillary sinus metastasis was diagnosed. Given the morphological characteristics, elevated Ki-67 expression and metastasis, this is a malignant tumor, which differentiates it from the basal cell adenoma


Assuntos
Adenocarcinoma , Glândula Parótida
8.
Arq. bras. med. vet. zootec. (Online) ; 70(2): 353-358, mar.-abr. 2018. tab, ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-910361

RESUMO

Sialolitíase é uma afecção que afeta as glândulas salivares ou seus ductos, caracterizada pela presença de estruturas calcificadas, denominadas de sialolitos, com crescimento lento e gradual, geralmente assintomático, dificultando ou impedindo o fluxo normal de saliva. Devido à ausência de relatos na literatura nacional, descreve-se o caso de uma égua de 15 anos, que apresentava um sialolito de 13cm no ducto parotídico havia mais de dois anos, próximo à crista facial. O diagnóstico foi realizado por meio do exame clínico: visualização do aumento de volume, palpação do sialolito, avaliação odontológica; e de exames complementares: radiografia e ultrassonografia. Optou-se pelo tratamento cirúrgico, através do acesso percutâneo, pois é o mais indicado para cálculos grandes, realizando-se sutura do ducto de Stenon, sem presença de fístulas no pós-operatório. Foi de extrema importância a avaliação e os cuidados odontológicos durante a realização do procedimento, pois as pontas dentárias facilitam a formação dos cálculos.(AU)


Sialolithiasis is a condition that affects the salivary glands or their ducts, characterized by the presence of calcified structures, called sialolites, with slow and gradual growth, usually asymptomatic, hindering or impeding the normal flow of saliva. Due to the absence of reports in the national literature, the case of a 15-year-old mare who had a 13cm sialolite in the parotid duct near the face ridge for more than 2 years is described. The diagnosis was made through clinical examination: with visualization and palpation of the sialolite, dental evaluation; and complementary exams: radiography and ultrasonography. We chose surgical treatment through percutaneous access, which is the most appropriate for large stones, and Stenon's duct suture was performed, without postoperative fistulas. The assessment and dental care during the procedure was extremely important, since the dental tips facilitate the formation of the stones.(AU)


Assuntos
Animais , Cavalos/anormalidades , Glândula Parótida/anormalidades , Cálculos das Glândulas Salivares/classificação
9.
Acta otorrinolaringol. cir. cabeza cuello ; 46(2): 144-149, 2018. tab, graf
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-970795

RESUMO

"Introducción: Los tumores de la glándula parótida son un motivo de consulta frecuente en los centros de referencia para patologías de cabeza y cuello. La mayoría son benignos. Sin embargo, requieren manejo quirúrgico por su localización evidente y riesgo de malignización. Objetivo: Describir las características clínicas y demográficas de pacientes con masas parotídeas en nuestra institución. Diseño: Estudio observacional descriptivo tipo serie de casos. Materiales y métodos: Se realizó un estudio descriptivo de los pacientes con diagnóstico de masa parotídea en el Servicio de Otorrinolaringología del Hospital Universitario del Valle entre 01/2011- 06/2014. Resultados: El total de registros fue de 61 pacientes. 20 parotidectomías se realizaron en hombres (32.8%) y 41 en mujeres (67.2%). 7 pacientes (11.5%) tenían 18-30años, 28 (45.9%), 31-50años y 26 (42.6%) más de 50 años. 32 presentaban un tamaño tumoral de 10-39mm (52.5%), 25 (41%) 40-89mm y 3 ≥90mm (4.9%). A 36 se les practicó TAC de cuello (59%). A 47 se les tomó 0BACAF (77%), a 15 TRUCUT (24.6%) y ninguno se llevó a biopsia excisional. El resultado patológico final fue benigno en un 63.9% y maligno en 13.1%. Discusión: Los tumores de parótida son relativamente frecuentes en la consulta Otorrinolaringológica y de Cirugía de Cabeza y Cuello. En nuestro país no encontramos una caracterización de esta entidad y en los pocos centros de referencia, se encontraron datos de patología maligna exclusivamente. Conclusiones: La información presentada abre la posibilidad a estudios ulteriores que permitan definir protocolos de manejo para esta patología en nuestro país. "


"Introduction: The tumors of the parotid gland are a frequent reason for consultation in reference centers for head and neck pathologies. Most are benign. However, a surgical management is required because of their evident location and risk of malignancy. Objective: To describe the clinical and demographic characteristics of patients with parotid masses in our institution. Design: Case series study. Materials and methods: A descriptive study of patients operated on with diagnosis of parotid mass in the Otorhinolaryngology Service of the Hospital Universitario del Valle between 01/2011-06/2014 was carried out. Results: The total of records was 61 patients. 20 parotidectomies were performed in men (32.8%) and 41 in women (67.2%). 7 patients (11.5%) were 18-30 years old, 28 (45.9%), 31-50 years old and 26 (42.6%) >50 years old. 32 had a tumor size of 10-39mm (52.5%), 25 (41%) 40-89mm and 3 ≥90mm (4.9%). A neck CT scan was performed in 36 patients (59%). 47 were underwent a Fine Needle Aspiration biopsy (77%), 15 TRU-CUT (24.6%); excisional biopsy was not carried out. The final pathological result was benign in 63.9% and malignant in 13.1% of the cases. Discussion: Parotid tumors are relatively frequent in the Otorhinolaryngology and Head and Neck Surgery outpatient care. In our country we did not find a characterization of this entity and as for the few reference centers, only malignant pathology data were found. Conclusions: The information presented in this paper opens up the possibility for further studies to define management protocols for this pathology in our country."


Assuntos
Humanos , Glândula Parótida , Adenoma Pleomorfo , Neoplasias de Cabeça e Pescoço
10.
Arq. bras. med. vet. zootec. (Online) ; 70(3): 758-766, maio-jun. 2018. ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-911306

RESUMO

A 9-year-old Girolando dairy cow, weighing 400kg, with a history of increased volume in the right parotid region, which extended to the submandibular region, was assisted. Fine needle aspiration cytology was performed, and the cytological findings were consistent with malignant neoplasm of epithelial origin (carcinoma). Because of the unfavorable prognosis, the animal was euthanized and submitted to an anatomopathological examination. Samples of the increased parotid and affected lymph nodes were collected for histopathological evaluation. The microscopic changes were accentuated features of anaplasia, moderate cell proliferation, atypical mitotic figures, and necrosis. Stroma ranged from delicate to scirrhous, and the tumor boundaries were not distinct. These findings substantiated the preliminary histomorphological diagnosis of undifferentiated carcinoma with metastasis in lymph nodes. Immunohistochemical tests were performed with anti-CK Pan (clone AE1AE3), anti-CK HMW (clone 34ßE12), anti-CK19 (clone RCK108), anti-vimentin (clone V9), anti-S100 (polyclonal), and anti-androgen (polyclonal) antibodies. The immunophenotype favored the diagnosis of salivary gland adenocarcinoma. Despite the rareness in cattle, salivary gland adenocarcinoma should be considered in the differential diagnosis of diseases that occur with increased volume in the head, lymphadenopathy, drooling, dysphagia, and progressive weight loss.(AU)


Foi atendida uma vaca da raça Girolando, de nove anos de idade, de aptidão leiteira, pesando aproximadamente 400kg e com histórico de aumento de volume na região parotídea e submandibular direita. Diante do prognóstico desfavorável, o animal foi submetido à eutanásia e encaminhado para exame anatomopatológico. Fragmentos da glândula parótida e dos linfonodos alterados foram colhidos e encaminhados para exame histopatológico. À avaliação microscópica, observaram-se acentuada anaplasia, moderada proliferação celular, figuras de mitose atípicas e focos de necrose. O estroma variava de delicado a esquirroso e os limites do tumor eram imprecisos. Esses achados fundamentaram o diagnóstico de carcinoma indiferenciado com metástase em linfonodos. No exame imuno-histoquímico, foram utilizados anticorpos primários monoclonais anti-CK Pan (clone AE1AE3), anti-CK alto peso molecular (clone 34ßE12), anti-CK19 (clone RCK108), antivimentina (clone V9), anti-S100 (policlonal) e antirreceptor de andrógenos (policlonal). As células neoplásicas apresentaram imunomarcação para todos os anticorpos testados, resultado que favorece o diagnóstico de adenocarcinoma de glândula salivar. Embora raro em bovinos, o adenocarcinoma de glândula salivar deve ser considerado no diagnóstico diferencial de doenças que cursam com aumento de volume na cabeça, linfadenopatia salivação, disfagia e emagrecimento progressivo.(AU)


Assuntos
Animais , Feminino , Bovinos , Adenocarcinoma/classificação , Bovinos/anormalidades , Glândula Parótida/anormalidades , Glândulas Salivares/citologia , Imuno-Histoquímica/classificação
11.
Int. j. morphol ; 35(4): 1332-1336, Dec. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-893137

RESUMO

SUMMARY: The present study was undertaken to elucidate ultrastructural changes in development of parotid salivary gland of buffalo during different stages of prenatal life. The ultrastructural studies revealed that the cytoplasm of acinar cells was filled with mitochondria, rough endoplasmic reticulum and Golgi complex in mid and late foetal age groups. Medium electron dense secretory granules first appeared in the acinar cells of parotid gland at 30 cm CVRL (141st day). However, at 49.5 cm CVRL (185th day) two types of electron dense granules were identified on basis of granule density viz., dark and light. The dark electron dense granules were more in number, whereas light granules were comparatively less having electron lucent content within them was identified. The mean diameter of dark and light granules was measured about 0.45±0.1 µm and 0.30±0.1 µm, respectively, which showed that the dark granules were comparatively larger in size. The secretory granules were increased in number during the late foetal age group. The myoepithelial cells were located at the base of the acinar cells as well as intercalated and striated ducts, and were stellate in shape. The ultrastructure of myoepithelial cell revealed parallel stream of myofilaments in the cytoplasm and its processes. Lipofuscin pigments were also observed in between the acinar cells of parotid gland.


RESUMEN: El estudio se realizó para elucidar los cambios ultraestructurales en el desarrollo de la parótida del búfalo durante las diferentes etapas de la vida prenatal. Los estudios ultraestructurales revelaron que el citoplasma de las células acinares estaba saturado de mitocondrias, de retículo endoplasmático rugoso y Complexo golgiensis en las edades fetal media y tardía. Se observó un número mayor de gránulos oscuros densos de electrones, mientras que los gránulos ligeros fueron comparativamente menor en número con contenido de electrones. El diámetro medio de gránulos oscuros y ligeros se midió aproximadamente 0,45 / pm 0,1 / mu m y 0,30 / pm 0,1 / mu m, respectivamente, lo que mostró que los gránulos oscuros eran comparativamente mayores en tamaño. Los gránulos secretores aumentaron en número durante el último grupo de edad fetal. Las células mioepiteliales se localizaron en la base de las células acinares, así como en conductos intercalados y estriados, y tenían una forma estrellada. La ultraestructura de las células mioepiteliales reveló una corriente paralela de miofilamentos en el citoplasma y sus procesos. También se observaron pigmentos de lipofuscina entre las células acinares de la glándula parótida.


Assuntos
Animais , Feminino , Gravidez , Búfalos/anatomia & histologia , Glândula Parótida/ultraestrutura , Microscopia Eletrônica de Transmissão
12.
An. bras. dermatol ; 92(6): 864-866, Nov.-Dec. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-887108

RESUMO

Abstract: Salivary duct injury can be idiopathic, iatrogenic, or post-trauma and may result in sialocele or fistula. Most injuries regress spontaneously and botulinum toxin A is one of several therapeutic possibilities. We report a case of iatrogenic injury to the parotid duct after Mohs' micographic surgery for a squamous cell carcinoma excision in the left jaw region, treated by injection of botulinum toxin type A. Although the fistula by duct injury can be self-limiting, botulinum toxin injection by promoting the inactivity of the salivary gland allows rapid healing of the fistula.


Assuntos
Humanos , Masculino , Idoso , Glândula Parótida/lesões , Fístula das Glândulas Salivares/tratamento farmacológico , Toxinas Botulínicas Tipo A/administração & dosagem , Fármacos Neuromusculares/administração & dosagem , Glândula Parótida/cirurgia , Carcinoma de Células Escamosas/cirurgia , Neoplasias Mandibulares/cirurgia , Injeções Intralesionais , Cirurgia de Mohs/efeitos adversos , Fístula das Glândulas Salivares/etiologia , Resultado do Tratamento
13.
J. appl. oral sci ; 24(6): 561-567, Nov.-Dec. 2016. tab, graf
Artigo em Inglês | LILACS | ID: biblio-841148

RESUMO

ABSTRACT Objective Fine-needle aspiration cytology is a valuable method for preoperative assessment of head and neck tumors. However, its accuracy in detection of salivary gland masses is controversial compared with other methods. The aim of this work was to evaluate the effectiveness and accuracy of fine-needle aspiration cytology (FNAC) in the diagnosis of parotid gland masses. Material and Methods Over a 10-year period, 126 parotid gland masses were resected. Retrospective chart reviews of 114 patients were performed. The results of FNAC and final histological diagnosis were compared and the accuracy of FNAC was determined. Results Final histological evaluation revealed 11 malignant tumors and 103 benign lesions. Pleomorphic adenoma was the most common neoplasm (63%), followed by Warthin’s tumor (17.5%). The sensitivity of FNAC in detecting malignant tumors was 73% and the specificity was 97%. Positive predictive value (PPV) was 73% and negative predictive value (NPV) was 97%. The overall accuracy of FNAC in detecting parotid masses was 95%. False-negative diagnosis was found in mucoepidermoid carcinoma, acinic cell carcinoma, and epithelial-myoepithelial carcinoma whereas there was false-positive diagnosis in cases of pleomorphic adenoma and normal parotid gland tissue. Conclusion FNAC is a reliable minimally invasive diagnostic method with a high sensitivity in diagnosis of lesions in parotid glands. The sensitivity of detection of malignant tumors in parotid glands was low due to the biopsy technique used, and depended on tumor location. Postoperative complications decreased after superficial parotidectomy.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Adulto Jovem , Adenoma Pleomorfo/patologia , Glândula Parótida/patologia , Neoplasias Parotídeas/patologia , Complicações Pós-Operatórias , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade
14.
Rev. chil. cir ; 68(5): 376-378, oct. 2016. ilus
Artigo em Espanhol | LILACS | ID: lil-797348

RESUMO

Objetivo: Reportar casos de linfadenoma sebáceo, un tumor raro, localizado principalmente en la glándula parótida, con muy pocos casos descritos en la literatura. Casos clínicos: Presentamos 2 casos de esta rara afección, tratados en el Hospital Universitario Miguel Servet de Zaragoza, de enero de 2010 a diciembre de 2014. El diagnóstico, tanto por imagen como citológico, es difícil debido a su baja prevalencia y a la gran variedad de tumores de glándula parótida que existen. En los 2 casos presentados ha sido necesaria la exéresis para llegar al diagnóstico. El tratamiento curativo consiste en la exéresis completa de la tumoración.


Aim: To report a rare parotid tumour: sebaceous lymphadenoma, with very few cases reported in the literature. Cases report: We present 2 cases of lymphadenoma sebaceous of the parotid gland treated by surgery at University Hospital Miguel Servet of Zaragoza between January 2010 and December 2014. The diagnosis, both radiological and cytological, is difficult because of their low prevalence and the great variety of parotid gland tumors existent. In our 2 cases described, excision has been required for diagnosis. A complete excision of the tumor is required for curative treatment.


Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Glândula Parótida/patologia , Neoplasias Parotídeas/cirurgia , Adenolinfoma/cirurgia , Glândula Parótida/cirurgia , Neoplasias Parotídeas/diagnóstico , Adenolinfoma/diagnóstico , Estudos Retrospectivos
15.
Rev. cuba. cir ; 55(2): 0-0, abr.-jun. 2016. ilus
Artigo em Espanhol | LILACS | ID: lil-791497

RESUMO

El carcinoma epidermoide de piel posee una elevada incidencia en países pertenecientes al cinturón ecuatorial o con climas muy secos y soleados. Se relaciona con la exposición prolongada a las radiaciones ultravioletas, enfermedades como el Xeroderma Pigmentoso, dermatosis de larga evolución, infecciones e inmunosupresiones. Aparece con mucha frecuencia en la piel del territorio de cabeza y cuello, lo cual complejiza las posibilidades reconstructivas en muchos pacientes. Se presenta el caso de un paciente masculino de 66 años con diagnóstico de carcinoma epidermoide cutáneo en la región parotidea. Se efectuó una parotidectomía subtotal extendida a piel y se utilizó un colgajo miofascial temporal ipsilateral para la reconstrucción del defecto creado. El paciente se ha mantenido en seguimiento clínico por tres años y medio, no ha presentado recaídas, se encuentra controlado de su enfermedad y mantiene una buena apariencia estética. Esto refuerza la gran versatilidad de este colgajo dentro del arsenal reconstructivo(AU)


Epidermoid carcinoma of the skin has a high incidence in very dry and sunny countries or those belonging to the equatorial belt. It is related to lengthened exposure to ultraviolet radiation, diseases such as pigmentuous xeroderma, long evolution dermatosis, infections and immunosuppression. It appears frequently to the skin of the head and neck areas, which complicates reconstructive possibilities in many patients. The case of a 66-year-old male patient is presented, with a diagnosis of cutaneous squamous cell carcinoma in the parotid region. An extended subtotal parotidectomy was performed to the skin and ipsilateral temporal myofascial flap was used for reconstruction of the occurring defect. The patient has remained in clinical follow-up for three years and a half, he has not presented relapses, his disease is under control and he maintain good aesthetic appearance. This reinforces the versatility of this flap within the reconstructive spectrum(AU)


Assuntos
Humanos , Masculino , Idoso , Carcinoma de Células Escamosas/diagnóstico , Glândula Parótida/lesões , Retalhos Cirúrgicos/efeitos adversos , Retalhos Cirúrgicos/cirurgia
16.
Acta cir. bras ; 31(2): 92-102, Feb. 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-775568

RESUMO

PURPOSE The parotidectomy technique still has an elevated paresis and paralysis index, lowering patient life's quality. The correct identification of the facial nerve can prevent nerve damage. Fluorescent dye identifies nerves in experimental studies but only few articles focused its use on facial nerve study in parotidectomies. We aimed to stain the rat facial nerve with fluorescent dye to facilitate visualization and dissection in order to prevent injuries. METHODS Forty adult male Wistar rats were submitted to facial injection of saline solution (Gsf-control group, 10) or fluorescent dye solution (Gdye group, 30) followed by parotidectomy preserving the facial nerve, measuring the time for localization and facility of localization (LocTime and LFN). Nerve function was assessed using the Vibrissae Movements (PMV) and Eyelid Closure Motion (PFP) scores. RESULTS Nerve localization was faster in Gdye group, with 83% Easy LFN rate. The Gdye group presented with low nerve injury degree and better PMV and PFP scores, with high sensitivity and accuracy. CONCLUSIONS This experimental method of facial nerve fluorescence was effective for intraoperative nerve visualization, identification and preservation. The technique may be used in future facial nerve studies, translated to humans, contributing to the optimization of parotid surgery in the near future.


Assuntos
Animais , Masculino , Glândula Parótida/cirurgia , Carbocianinas/administração & dosagem , Nervo Facial/cirurgia , Corantes Fluorescentes/administração & dosagem , Fatores de Tempo , Variações Dependentes do Observador , Sensibilidade e Especificidade , Ratos Wistar , Modelos Animais , Dissecação/métodos , Microinjeções/instrumentação , Microscopia de Polarização
17.
Belo Horizonte; s.n; 2016. 68 p. ilus, tab.
Tese em Português | LILACS | ID: lil-790290

RESUMO

Há controvérsia sobre os efeitos e impactos da radiação não ionizante emitida por telefones celulares sobre os mecanismos fisiológicos. Resultados conflitantes já foram relatados sobre a associação entre o uso de telefone celular e desenvolvimento de tumores em parótida. A inflamação crônica está associada com um risco aumentado de câncer, tal como pode ser visto na colite ulcerativa. Para avaliar o possível efeito do uso do telefone celular na glândula salivar parótida, o perfil de expressão de citocinas foi determinado na saliva produzida pelas glândulas parótidas em voluntários saudáveis e, correlacionada com o perfil de uso do telefone celular. Foram avaliados 83 indivíduos saudáveis, a partir de saliva produzida por essas glândulas...


Assuntos
Humanos , Masculino , Feminino , Inflamação , Interleucinas , Glândula Parótida , Radiação não Ionizante , Telefone Celular , Exposição à Radiação , Proteínas e Peptídeos Salivares
18.
Braz. dent. sci ; 19(1): 120-124, 2016. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: lil-785288

RESUMO

Mioepitelioma é um tumor benigno de glândula salivar que acomete, principalmente, a glândula parótida. Apresença de uma glândula parótida acessória é uma variação anatômica e neoplasias nessa estrutura são extremamente raras. Este artigo descreve um caso de mioepitelioma ocorrendo em uma glândula parótidaacessória de uma mulher de 29 anos de idade. No entendimento dos autores este é o sétimo caso relatado em Inglês. A queixa da paciente era umamassa na bochecha, com cinco anos de evolução, apresentando súbito surto de crescimento. A paciente foi submetida à cirurgia por meio de uma abordagemintra-bucal e a histopatologia e a imunohistoquímica revelaram um mioepitelioma.


Myoepithelioma is a benign tumor of the salivary gland that mainly affects the parotid gland. The presence of an accessory parotid gland is an anatomical variation and neoplasms in this structure are extremely rare. This paper describes a case of a myoepithelioma arising in the accessory parotid gland of a 29-year-old woman. To the author´s knowledge this is the seventh case reported in English. The patient´s complaint was about a five year growing mass in the left cheek with a sudden growth outbreak. The patient underwent surgery via an intra-oral approach and the histopathology and the immunohistochemistry disclosed a myoepithelioma.


Assuntos
Humanos , Feminino , Adulto , Neoplasias Bucais , Mioepitelioma , Glândula Parótida
19.
Int. j. med. surg. sci. (Print) ; 3(2): 839-842, 2016. ilus
Artigo em Espanhol | LILACS | ID: lil-790612

RESUMO

El sialocele es una colección de saliva en los tejidos que rodean al conducto de la glándula o del parénquima sin un drenaje adecuado. Su causa más común es la extravasación de saliva producto a un disrupción del parénquima o conducto parotídeo secundario a un trauma cortante. Si el tratamiento del sialocele no se realiza en forma oportuna se puede generar una fístula externa, cicatrices faciales e infecciones secundarias. Un hombre de 24 años ingresado al Hospital con múltiples fracturas faciales sin trauma cortante. Luego de la disminución del edema, continuó el aumento de volumen en la región geniana en forma localizada, fluctuante, ovalada. La piel se encontraba distendida, asintomática, sin secreciones, con alteración de la función motora y sensorial en la región geniana derecha. Se realizó la aspiración del contenido del aumento de volumen. Después de 2 días recidivó. Se solicitó una Tomografía computarizada y se volvió a realizar aspiración del contenido para enviarlo a cultivo citológico. Se hizo el diagnóstico de sialocele post-trauma de la parótida y se realizó un vaciamiento del contenido y drenaje tipo penrose intraoral. Se controló al siguiente día sin recidivas y se retiró el drenaje a los 2 meses. Es importante tener en cuenta que se puede generar un sialocele post-trauma sin necesariamente ser cortante...


Sialocele is a collection of saliva in the tissues surrounding the duct of the gland or parenchyma without proper drainage. The most common cause is the extravasation of saliva product to a disruption of the parenchyma or parotid duct secondary to a cutting trauma. If sialocele treatment is not performed in a timely manner it can generate an external fistula, facial scars and secondary infections. Male admitted to hospital with multiple facial fractures. After the reduction of edema, continued increased volume in the preauricular region localized, fluctuating, oval. The skin was asymptomatic, without secretions, with impairment of motor and sensory function in the right genial region. The aspiration of the increase in volume under a hypothesized hematoma was performed. After 2 days recurred. A tomography scan was requested and returned to realize the aspiration of which was sent to cytological exam. The diagnosis was post-trauma sialocele parotid and was performed emptying the contents and drainage type penrose intraoral. Was control the next day without relapses and the drain was removed after 2 months. It ́s important to know that can generate a post-trauma sialocele without necessarily cutting trauma...


Assuntos
Humanos , Masculino , Adulto , Doenças Parotídeas/etiologia , Doenças Parotídeas/terapia , Ferimentos e Lesões/complicações , Acidentes de Trânsito , Drenagem , Doenças das Glândulas Salivares/etiologia , Doenças das Glândulas Salivares/terapia , Glândula Parótida/lesões
20.
Rev. Asoc. Odontol. Argent ; 103(3): 116-119, jul.-sept. 2015. ilus
Artigo em Espanhol | LILACS | ID: lil-768635

RESUMO

Objetivo: determinar la terapéutica más efectiva para el tratamiento del síndrome de Frey. Caso clínico: un paciente de sexo femenino, de 68 años de edad, se presentó a la consulta en el Servicio de Cirugía Bucomaxilofacial de la Unidad Asistencial Por + Salud Dr. César Milstein, por sudoración cervical molesta del lado izquierdo. Fue tratada con infiltración subcutánea de toxina botulínica por desarrollar síndrome de Frey posparotidectomía. Conclusión: actualmente, la infiltración subcutánea de toxina botulínica de tipo A constituye la primera opción de tratamiento, pues brinda resultados efectivos y seguros.


Assuntos
Humanos , Feminino , Idoso , Glândula Parótida/patologia , Sudorese Gustativa/complicações , Toxinas Botulínicas Tipo A/uso terapêutico , Argentina , Assistência Odontológica para Doentes Crônicos/métodos , Unidade Hospitalar de Odontologia
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