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1.
Rev. cuba. salud pública ; 44(1)2018. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1042969

RESUMO

Introducción: La borreliosis de Lyme no ha sido notificada oficialmente en Cuba pero existen sospechas clínico-epidemiológicas y evidencias serológicas sugestivas de la infección por Borrelia burgdorferi sensu lato, su agente causal. Objetivo: Describir aspectos clínicos y epidemiológicos de pacientes que padecieron la enfermedad y explorar el nivel de conocimientos en personal médico. Métodos: Se realizó revisión documental de los Registros de Diagnóstico de la infección por B. burgdorferi sensu lato, entre 2007-2016, conservados en el Laboratorio Nacional de Referencia del Instituto de Medicina Tropical Pedro Kourí y se combinó con un estudio exploratorio del nivel de conocimientos sobre la enfermedad en personal médico. Resultados: Hubo incremento discreto en el número de muestras recepcionadas. El suero y el líquido cefalorraquídeo, fueron las muestras de elección para el diagnóstico, realizado por ensayos inmunoenzimáticos. Se confirmó la infección en 10,9 por ciento de las muestras de sueros recibidas. Las lesiones en piel, adenopatías regionales, parálisis faciales, dificultad para la marcha y otras, motivaron la sospecha clínica de esta enfermedad. Predominó el antecedente de picaduras por insectos o garrapatas. El 70 por ciento de los médicos encuestados plantearon conocer sobre la enfermedad de Lyme, pero de ellos solo el 46 por ciento reconoció al menos una de sus manifestaciones clínicas. Conclusiones: Los aspectos clínicos y epidemiológicos descritos, deben ser tomados en cuenta en pacientes con sintomatologías compatibles con la infección por B. burgdorferi sensu lato. Se requieren intervenciones educativas en el personal médico para un mejor reconocimiento clínico de esta entidad infecciosa y propiciar un mejor diagnóstico(AU)


Introduction: Lyme borreliosis has not been officially reported in Cuba but there are clinical-epidemiological suspicions and serological evidence that are suggestive of its causal agent: the infection by Borrelia burgdorferi sensu lato. Objective: To describe clinical and epidemiological aspects of patients who suffered from the disease and to explore the level of knowledge about it in medical personnel. Methods: A documentary review of the Diagnostic Records of B. burgdorferi sensu lato infection that are preserved in the National Reference Laboratory of Pedro Kourí Institute of Tropical Medicine was carried out from 2007 to 2016, and it was combined with an exploratory study of the knowledge´s level about the disease in medical personnel. Results: There was a slight increase in the number of samples received. Serum and cerebrospinal fluid were the samples chosen for a diagnosis that was performed by enzyme immunoassay. Infection was confirmed in 10.9 percent of the serum samples received. Skin lesions, regional lymphadenopathy, facial paralysis, difficulty for walking and others led to the clinical suspicion of this disease. It was predominant the antecedent of insect or tick bites. Seventy percent of the doctors surveyed said they knew about Lyme disease, but only 46 percent of them acknowledged at least one of its clinical manifestations. Conclusions: B. burgdorferi sensu lato infection should be taken into account in patients with symptoms compatible with Lyme disease. Educational interventions are required in the medical personnel for a better clinical recognition of this infectious entity and to promote a better diagnosis(AU)


Assuntos
Infestações por Carrapato/epidemiologia , Doença de Lyme/diagnóstico , Inquéritos e Questionários , Cuba
2.
Acta neurol. colomb ; 34(3): 195-198, sep.2018.
Artigo em Espanhol | LILACS | ID: biblio-983719

RESUMO

RESUMEN El síndrome de Lyme crónico representa un término controversial que agrupa un conjunto de síntomas persistentes e inespecíficos, en su mayoría reumatológicos o neurológicos, dentro de los cuales se encuentra la enfermedad postLyme, cuya incidencia epidemiológica es baja, el conocimiento fisiopatológico es controversial y el abordaje diagnóstico se basa especialmente en la interpretación clínica, dirigiendo su enfoque terapéutico hacia la resolución sintomática. Se presenta un caso de una mujer de 17 años, con enfermedad de Lyme de reciente diagnóstico, de aparente evolución de 3 años, con diagnóstico previo de enfermedad desmielinizante, que consultó por deterioro neurológico. Se revisan consideraciones científicas sobre su aproximación clínica y principios terapéuticos, los cuales se contrastan con los aplicados.


SUMMARY Chronic Lyme syndrome represents a controversial term that groups together a set of persistent and nonspecific symptoms, mostly rheumatological and / or neurological, among which is the Post Lyme Disease, whose epidemiological incidence is low, pathophysiology is controversial and the diagnostic approach is based especially on clinical interpretation, directing its therapeutic approach towards symptomatic resolution. We present a case of a female patient of 17 years of age with Lyme disease of recent diagnosis of apparent evolution of 3 years, with previous diagnosis of demyelinating disease, who consulted for neurological deterioration. Scientific considerations on its clinical approach and therapeutic principles are reviewed, contrasting them with those applied.


Assuntos
Doença de Lyme , Borrelia burgdorferi
4.
Braz. j. microbiol ; 48(1): 167-172, Jan.-Mar. 2017.
Artigo em Inglês | LILACS | ID: biblio-839354

RESUMO

Abstract Borreliosis caused by Borrelia burgdorferi sensu lato is a cosmopolitan zoonosis studied worldwide; it is called Lyme disease in many countries of the Northern Hemisphere and Lyme-like or Baggio-Yoshinari Syndrome in Brazil. However, despite the increasing number of suspect cases, this disease is still neglected in Brazil by the medical and veterinary communities. Brazilian Lyme-like borreliosis likely involves capybaras as reservoirs and Amblyomma and Rhipicephalus ticks as vectors. Thus, domestic animals can serve as key carriers in pathogen dissemination. This zoonosis has been little studied in horses in Brazil. The first survey was performed in the state of Rio de Janeiro, and this Brazilian Borreliosis exhibits many differences from the disease widely described in the Northern Hemisphere. The etiological agent shows different morphological and genetic characteristics, the disease has a higher recurrence rate after treatment with antibiotics, and the pathogen stimulates intense symptoms such as a broader immune response in humans. Additionally, the Brazilian zoonosis is not transmitted by the Ixodes ricinus complex. With respect to clinical manifestations, Baggio-Yoshinari Syndrome has been reported to cause neurological, cardiac, ophthalmic, muscle, and joint alterations in humans. These symptoms can possibly occur in horses. Here, we present a current panel of studies involving the disease in humans and equines, particularly in Brazil.


Assuntos
Humanos , Animais , Doença de Lyme/microbiologia , Doença de Lyme/epidemiologia , Borrelia burgdorferi/genética , Borrelia burgdorferi/imunologia , Doenças dos Cavalos/microbiologia , Doenças dos Cavalos/epidemiologia , Brasil/epidemiologia , Doença de Lyme/diagnóstico , Doença de Lyme/transmissão , Zoonoses , Doenças dos Cavalos/diagnóstico , Doenças dos Cavalos/transmissão , Cavalos , Antibacterianos/uso terapêutico
6.
Biomédica (Bogotá) ; 36(supl.1): 109-117, dic. 2016. graf, tab
Artigo em Espanhol | LILACS | ID: lil-783528

RESUMO

Introducción. La enfermedad de Lyme es una zoonosis multisistémica causada por Borrelia burgdorferi sensu lato. Esta espiroqueta circula en un ciclo enzoótico entre un reservorio vertebrado primario y las garrapatas. Se ha encontrado que varias especies de roedores son eficientes reservorios naturales de B. burgdorferi s.l. Objetivo. Estimar la prevalencia de B. burgdorferi s.l. en roedores sinantrópicos en dos comunidades rurales de Yucatán, México. Materiales y métodos. Se capturaron 123 roedores (94 Mus musculus y 29 Rattus rattus ) para obtener muestras de tejidos de oreja y vejiga. Para la detección de B. burgdorferi s.l. en las muestras, se amplificaron los genes de la flagelina B ( fla B ) y las lipoproteínas de membrana externa, ospC y p66 , mediante reacción en cadena de la polimerasa, y se secuenciaron los amplicones obtenidos. Resultados. La frecuencia de infección por B. burgdorferi s.l. en roedores fue de 36,5 % para flaB (45/123), de 10,5 % (13/123) para p66 y de 3,2 % (4/123) para ospC . En R. rattus la frecuencia de infección fue de 17,2 % y en M. musculus fue de 42,5 %. La frecuencia de infección de B. burgdorferi s.l. en los tejidos estudiados fue de 11,3 % (14/123) en muestras de tejido de vejiga y de 17,0 % (21/123) en las de oreja. No se encontraron diferencias estadísticas (p>0,05) en la frecuencia de infección entre los dos tipos de muestras de tejido utilizadas para el diagnóstico. El gen ospC presentó 98 % de homología con la especie Borrelia garinii , una de las especies heterogéneas del complejo B. burgdorferi s.l. Conclusiones. Los roedores presentaron una alta prevalencia de infección con B. burgdorferi s.l.; las especies M. musculus y R. rattus podrían jugar un papel importante en la continuidad de la presencia de esta bacteria en comunidades rurales de Yucatán, México.


Introduction: Lyme disease is a multisystemic zoonotic disease caused by Borrelia burgdorferi sensu lato. This spirochete circulates in an enzootic cycle between the primary vertebrate reservoir and its tick vectors. Different species of rodents are known to be efficient natural reservoirs for B. burgdorferi s.l. Objective: To estimate the prevalence of B. burgdorferi s.l. in synanthropic rodents from two rural communities of Yucatán, México. Materials and methods: A total of 123 rodents (94 Mus musculus and 29 Rattus rattus ) were trapped, and ear and bladder samples were collected. Flagelin B ( flaB ) genes and outer membrane lipoproteins ospC y p66 were amplified in order to detect B. burgdorferi s.l. presence in the samples. The obtained amplicons were sequenced. Results: The overall infection rates in rodents were 36.5% for flaB (45/123), 10.5% (13/123) for p66, and 3.2% (4/123) for ospC . Rattus rattus had 17.2% of infection and M. musculus , 42.5%. From all examined tissue, 11.3% (14/123) of bladders, and 17.0% (21/123) of ears were infected with the spirochete Borrelia burgdorferi s.l. No statistical differences (p>0.05) were found between the two tissue samples used for diagnosis. The ospC gen was 98% homologous to Borrelia garinii , one species of the B. burgdorferi s.l. complex. Conclusions: We concluded that rodents have a high prevalence of B. burgdorferi s.l. infection, and both species of rodents, M. musculus and R. rattus, might be playing an important role in the maintenance of this bacterium in rural communities of Yucatán, México.


Assuntos
Borrelia burgdorferi , Doença de Lyme , México , Roedores , População Rural
7.
Braz. j. microbiol ; 46(3): 807-814, July-Sept. 2015. tab, ilus
Artigo em Inglês | LILACS | ID: lil-755802

RESUMO

Lyme disease (LD) is a natural focal zoonotic disease caused by Borrelia burgdorferi, which is mainly transmitted through infected Ixodes ricinus tick bites. The presence and abundance of ticks in various habitats, the infectivity rate, as well as prolonged human exposure to ticks are factors that may affect the infection risk as well as the incidence of LD. In recent years, 20% to 25% of ticks infected with different borrelial species, as well as about 5,300 citizens with LD, have been registered in the Belgrade area. Many of the patients reported tick bites in city’s grassy areas. The aim of this study was to assess the seroprevalence of B. burgdorferi in high-risk groups (forestry workers and soldiers) in the Belgrade area, and to compare the results with healthy blood donors. A two-step algorithm consisting of ELISA and Western blot tests was used in the study. Immunoreactivity profiles were also compared between the groups. The results obtained showed the seroprevalence to be 11.76% in the group of forestry workers, 17.14% in the group of soldiers infected by tick bites and 8.57% in the population of healthy blood donors. The highest IgM reactivity was detected against the OspC protein, while IgG antibodies showed high reactivity against VlsE, p19, p41, OspC, OspA and p17. Further investigations in this field are necessary in humans and animals in order to improve protective and preventive measures against LD.

.


Assuntos
Adulto , Animais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anticorpos Antibacterianos/sangue , Borrelia burgdorferi/imunologia , Borrelia burgdorferi/isolamento & purificação , Doença de Lyme/epidemiologia , Exposição Ocupacional , Ensaio de Imunoadsorção Enzimática , Agricultura Florestal , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Insetos Vetores/microbiologia , Ixodes/microbiologia , Doença de Lyme/microbiologia , Doença de Lyme/transmissão , Militares , Estudos Soroepidemiológicos , Inquéritos e Questionários , Sérvia/epidemiologia
8.
Braz. j. microbiol ; 46(2): 571-575, Apr-Jun/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-749742

RESUMO

This study describes the detection of Borrelia garinii and Borrelia burgdorferi sensu stricto (s.s.) in Brazilian individuals using PCR and DNA sequencing. Our results suggest that these species are emerging pathogens in this country, and additional studies are necessary to determine the epidemiological characteristics of this disease in Brazil.


Assuntos
Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Grupo Borrelia Burgdorferi/classificação , Grupo Borrelia Burgdorferi/isolamento & purificação , Doenças Transmissíveis Emergentes/microbiologia , Doença de Lyme/microbiologia , Sequência de Bases , Brasil/epidemiologia , Doenças Transmissíveis Emergentes/epidemiologia , DNA Bacteriano/química , DNA Bacteriano/genética , Doença de Lyme/epidemiologia , Dados de Sequência Molecular , Reação em Cadeia da Polimerase , População Rural , Alinhamento de Sequência , Análise de Sequência de DNA
9.
Rev. bras. parasitol. vet ; 23(2): 287-290, 06/2014. tab
Artigo em Inglês | LILACS | ID: lil-714790

RESUMO

The main of the study was to evaluate the presence of Borrelia burgdorferi infection in domestic and wild vertebrates and ectoparasites in endemic areas from the state of Minas Gerais, Brazil. A total of 445 serum samples were examined by ELISA, which used the Borrelia burgdorferi strain G39/40 U.S. source and 3,821 tick samples were tested by polymerase chain reaction (PCR). B. burgdorferi antibodies were found in 30 serum samples (6.74%); three in marsupials (7.69%), three in rodents (2.80%), nine in dogs (6.25%), and 15 in horses (9.68%). Nested-PCR performed in DNA samples obtained from collected ticks demonstrated negative results. Although attempts to amplify B. burgdorferi DNA from ticks had been not successful, the presence of seroreactive vertebrates suggests the possibility the Borrelia species circulating in these regions. Further research is required to provide information on the presence of Borrelia in Brazilian territory and its association with Baggio-Yoshinari syndrome.


O principal objetivo do estudo foi avaliar a presença de infecção por Borrelia burgdorferi em vertebrados domésticos e silvestres e ectoparasitas em áreas endêmicas do estado de Minas Gerais, Brasil. Um total de 445 amostras de soro foram examinadas por ELISA, onde usou-se a cepa americana G39/40 de Borrelia burgdorferi e 3.821 amostras de carrapatos foram testados pela reação em cadeia da polimerase (PCR). Anticorpos anti -B. burgdorferi foram encontrados em 30 amostras de soro (6,74%); três marsupiais (7,69%), três em roedores (2,80%), em nove cães (6,25%) e 15 em cavalos (9,68%). Nested-PCR realizada em amostras de DNA obtidas a partir de carrapatos coletados demonstraram resultados negativos. Apesar das tentativas para amplificar o DNA de B. burgdorferi a partir de carrapatos não tenha sido bem sucedido, a presença de soroatividade em vertebrados sugere a possibilidade de espécies de Borrelia circulando nestas regiões. Mais pesquisas são necessárias para fornecer informações sobre a presença de Borrelia em território brasileiro e sua associação com a Síndrome de Baggio-Yoshinari.


Assuntos
Animais , Cães , Animais Domésticos/microbiologia , Animais Selvagens/microbiologia , Borrelia burgdorferi/isolamento & purificação , Doenças do Cão/microbiologia , Doenças dos Cavalos/microbiologia , Doença de Lyme/veterinária , Marsupiais/microbiologia , Roedores/microbiologia , Brasil , Cavalos , Doença de Lyme/diagnóstico
10.
Rev. bras. reumatol ; 54(2): 148-151, Mar-Apr/2014. tab
Artigo em Português | LILACS | ID: lil-710223

RESUMO

A borreliose humana brasileira, também conhecida como Síndrome de Baggio-Yoshinari (SBY), é uma enfermidade infecciosa própria do território brasileiro, transmitida por carrapatos não pertencentes ao complexo Ixodes ricinus, causada por espiroqueta do gênero Borrelia e que apresenta semelhanças clínicas e laboratoriais com a Doença de Lyme (DL). A SBY distingue-se da DL por apresentar evolução clínica prolongada, com episódios de recorrência e importante disfunção autoimune. Descreveremos o caso de uma paciente jovem, que desenvolveu progressivamente durante cerca de um ano oligoartrite de grandes articulações, seguida de distúrbio do cognitivo, meningoencefalite e eritema nodoso. O diagnóstico foi firmado devido à concomitância de queixas articulares e neurológicas com sorologia positiva para Borrelia burgdorferi sensu stricto. A paciente foi medicada com ceftriaxone 2 g/EV/dia por 30 dias, seguido de dois meses de doxiciclina 100 mg duas vezes ao dia. Houve remissão dos sintomas e normalização dos exames sorológicos para a borreliose. A SBY é uma zoonose emergente descrita apenas no Brasil, cuja frequência tem crescido bastante, e que, em razão das importantes diferenças nos aspectos epidemiológicos, clínicos e laboratoriais em relação à DL, merece especial atenção da classe médica do país. Trata-se de zoonose camuflada e de difícil diagnóstico, mas este deve ser perseguido com tenacidade, pois a enfermidade responde aos antibióticos no estágio inicial, podendo evoluir com sequelas neurológicas e articulares nos casos reconhecidos tardiamente ou recorrentes.


The Brazilian human borreliosis, also known as Baggio-Yoshinari Syndrome (BYS), is a tickborne disease but whose ticks do not pertain to the Ixodes ricinus complex. It is caused by Borrelia burgdorferi sensu lato microorganisms and resembles clinical and laboratory features of Lyme disease (LD). BYS is also distinguished from LD by its prolonged clinical evolution, with relapsing episodes and autoimmune dysfunction. We describe the case of a young female who, over one year, progressively presented with oligoarthritis, cognitive impairment, menigoencephalitis and erythema nodosum. Diagnosis was established by means of the clinical history and a positive serology to Borrelia burgdorferi sensu strictu. The patient received Ceftriaxone 2 g IV/day during 30 days, followed by 2 months of doxicycline 100 mg bid. Symptoms remitted and the Borrelia serology tests returned to normality. BYS is a new disease described only in Brazil, which has a raising frequency and deserves the attention from the country´s medical board because of clinical, epidemiological and laboratory differences from LD. Despite the fact that it is a hard-to-diagnose zoonosis, it is important to pursuit an early diagnosis because the symptoms respond well to antibiotics or it might be resistant to treatment and may evolve to a chronic phase with both articular and neurological sequelae.


Assuntos
Adulto , Feminino , Humanos , Artrite/diagnóstico , Grupo Borrelia Burgdorferi , Eritema Nodoso/diagnóstico , Doença de Lyme/diagnóstico , Meningoencefalite/diagnóstico , Brasil , Recidiva , Síndrome
11.
Arq. neuropsiquiatr ; 71(7): 470-473, July/2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-679172

RESUMO

The Brazilian Lyme-disease-like illness (BLDLI) or Baggio-Yoshinari syndrome is a unique zoonosis found in Brazil. It reproduces all the clinical symptoms of Lyme disease except for the high frequencies of relapse and the presence of autoimmune manifestations. Two cases of borreliosis manifesting with unremitting headache, which is a symptom associated with late-stage BLDLI, were presented. Clinical, therapeutic, and prognostic aspects of the BLDLI and its associated headaches were showed and discussed in this article. BLDLI diagnosis requires additional attention by physicians, since the disease has a tendency to progress to the late, recurrent stage or the chronic form, and the associated headache can be confused with chronic primary headache or with analgesic-overuse one. Special attention should be paid to patients with headaches who have traveled to endemic areas.


A doença de Lyme símile brasileira (BLDLI) ou síndrome de Baggio-Yoshinari é uma zoonose diferenciada encontrada no Brasil. Ela reproduz todos os sintomas clínicos da doença de Lyme, exceto as altas frequências de recidivas e a presença de manifestações autoimunes. Dois casos de borreliose, manifestando-se com cefaleia incessante, que é um sintoma associado à fase tardia da BLDLI, foram apresentados. Os aspectos clínicos, terapêuticos e prognósticos da BLDLI, bem como as cefaleias associadas com a doença de Lyme, foram mostrados e discutidos. O diagnóstico da BLDLI requer maior atenção dos médicos, já que a doença tende a progredir em seu estágio tardio, na forma recorrente ou crônica, e a cefaleia pode ser confundida com cronificação primária ou por abuso excessivo de analgésicos. Atenção especial deve ser dada aos pacientes que viajaram para áreas endêmicas.


Assuntos
Adulto , Feminino , Humanos , Grupo Borrelia Burgdorferi , Transtornos da Cefaleia/etiologia , Doença de Lyme/complicações , Brasil , Doença Crônica , Doença de Lyme/diagnóstico , Doença de Lyme/terapia , Imagem por Ressonância Magnética , Resultado do Tratamento
12.
Rev. cuba. med. trop ; 65(2): 149-165, abr.-jun. 2013.
Artigo em Espanhol | LILACS | ID: lil-675497

RESUMO

Introducción: Borrelia burgdorferi sensu lato es el agente etiológico de la enfermedad de Lyme, zoonosis emergente de difícil diagnóstico, prevención y control, reportada fundamentalmente en el hemisferio norte. Objetivo: facilitar información actualizada acerca de Borrelia burgdorferi. Métodos: se realizó una revisión de la literatura científica y especializada sobre los principales aspectos relacionados con este agente y su enfermedad; como son las características de las borrelias y el ciclo de vida, epidemiología, manifestaciones clínicas en humanos, diagnóstico de laboratorio, definición actual de caso, tratamiento, profilaxis, prevención y control. Resultados: se expone información actualizada y valiosa sobre los temas seleccionados, útil para el personal interesado en las enfermedades infecciosas transmitidas por vectores. Se muestra además información sobre los estudios realizados en Cuba. Conclusiones: se aporta información de utilidad para el manejo epidemiológico, clínico y microbiológico de casos con sospechas de la infección por Borrelia burgdorferi sensu lato


Introduction: Borrelia burgdorferi sensu lato is the causative agent of Lyme disease, an emerging zoonosis, whose diagnosis, prevention and control are difficult and it is mainly reported in the northern hemisphere. Objective: to provide updated information about Borrelia burgdorferi. Methods: a review of scientific and specialized literature on the key aspects of this agent and the disease such as characteristics and life cycle of borrelias, epidemiology, clinical manifestations in humans, laboratory diagnosis, current case definition, treatment, prophylaxis, prevention and control. Results: current valuable information on selected items was set forth, which is useful for the personnel involved in vector-borne infectious diseases. Additionally, information about studies conducted in Cuba was provided. Conclusions: this paper offers updated information for the epidemiological, clinical and microbiological management of suspected cases of infection with Borrelia burgdorferi sensu lato


Assuntos
Humanos , Masculino , Feminino , Doença de Lyme/epidemiologia , Doença de Lyme/prevenção & controle , Grupo Borrelia Burgdorferi/patogenicidade , Infecções por Borrelia/epidemiologia , Infecções por Borrelia/prevenção & controle , Literatura de Revisão como Assunto
13.
Rev. cuba. med. trop ; 65(2): 277-280, abr.-jun. 2013.
Artigo em Espanhol | LILACS | ID: lil-675508

RESUMO

Como es conocido, Borrelia spp. constituye un grupo importante de patógenos bacterianos transmitidos por garrapatas, a excepción de Borrelia recurrentis que es transmitida por piojos del cuerpo. Estos microorganismos son los causantes de borreliosis o enfermedad de Lyme y fiebre recurrente.1El complejo B. burgdorferi sensu lato es causante de la enfermedad de Lyme, y el principal vector descrito lo constituyen las garrapatas duras del género Ixodes.2 Recientemente se ha reportado en México y Brasil la presencia de ADN de B. burgdorferi sensu stricto,3,4 una de las 19 genomaespecies del complejo, en garrapatas Amblyomma cajennense, pero se desconoce si esta especie es capaz de transmitir las borrelias a un nuevo hospedero. En Cuba, a partir de evidencias serológicas específicas de la infección por este agente y teniendo en cuenta las especies de ixódidos que prevalecen, así como sus características ecológicas y antropofílicas, las garrapatas A. cajennense y Rhipicephalus sanguineus se consideran vectores potenciales de las borrelias.5Sobre la base de los hallazgos e hipótesis anteriormente mencionados se hace necesario iniciar investigaciones para comprobar si otras especies diferentes de Ixodes spp. son capaces de transmitir las borrelias. Ello requiere contar con un método sencillo y eficaz que permita la infección artificial de ixódidos. Se han reportado disímiles estrategias con estos fines, entre las que se incluyen el empleo de cámaras de alimentación con membranas naturales o artificiales, la infusión por enema, la inoculación hemocélica y la alimentación por capilares...


Assuntos
Animais , Borrelia burgdorferi/patogenicidade , Doença de Lyme/prevenção & controle , Infestações por Carrapato/induzido quimicamente , Bioensaio , Experiências Laboratoriais
14.
Braz. j. microbiol ; 44(1): 125-131, 2013. ilus, tab
Artigo em Inglês | LILACS | ID: lil-676910

RESUMO

The aim of this study was to conduct a serological survey for Lyme diseases, brucellosis, leptospirosis and toxoplasmosis and identify the risk variables related to these zoonoses in humans living in the rural area of Jataizinho, state of Parana, Brazil. A total of 63 rural properties were surveyed. Additionally, 207 serum samples collected from these rural area inhabitants were tested for indirect immunofluorescence (IFI) and western blots (WB) were performed to detect Borrelia burgdorferi (sensu lato); a tamponated acidified antigen test (AAT) and 2-mercaptoethanol (2-ME) were used to detect antibodies of Brucella abortus; the microscopic agglutination test (MAT) was carried out to detect antibodies anti-Leptospira spp. and IFI was used to find antibodies of Toxoplasma gondii. Two of the samples (0.96%) were reactive for Lyme borreliosis, three (1.4%) for brucellosis, 25 (12.1%) for leptospirosis and 143 (69.1%) for toxoplasmosis. Although the town of Jataizinho has a human development index (IDH) that was considered to be average (0.733) in the state of Parana, the low social, economic and cultural conditions of the population from small rural properties have resulted in lack of basic information on animal health and direct or indirect contact with the various species of domestic animals, wildlife and ticks have probably contributed to the prevalence levels found. These results show the need for additional regional studies in order to determine the epidemiological characteristics of these diseases as well as their respective vectors and reservoirs so that effective prophylaxis can be administered in the human population.


Assuntos
Humanos , Animais , Anticorpos , Brucelose , Leptospirose , Doença de Lyme , Sorologia , Aglutinação , Imunofluorescência , Métodos , Técnicas , Zoonoses
15.
Braz. j. infect. dis ; 16(6): 586-589, Nov.-Dec. 2012.
Artigo em Inglês | LILACS | ID: lil-658929

RESUMO

Lyme disease is an underdiagnosed zoonosis in Brazil. There are no cases registered in the state of Tocantins, the newest Brazilian state. The cases of three patients in contact with rural areas in three Tocantins' districts are herein described, and the Brazilian literature is reviewed.


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Doença de Lyme/diagnóstico , Brasil/epidemiologia , Doença de Lyme/epidemiologia
17.
Rev. cuba. hig. epidemiol ; 50(2): 231-244, Mayo-ago. 2012.
Artigo em Espanhol | LILACS | ID: lil-654519

RESUMO

Objetivo: teniendo en cuenta el riesgo potencial que para Cuba constituye la presencia del agente trasmisor, los autores consideran importante la revisión del tema con vistas a una actualización de los especialistas y demás entidades del sistema de salud que puedan intervenir en la vigilancia y control epidemiológico de esta enfermedad. Desarrollo: se comenta la historia de la enfermedad, la microbiología, la epizootiología y la epidemiología, así como las manifestaciones clínicas en los principales animales domésticos. Conclusiones: la borreliosis de Lyme es una nueva enfermedad infecciosa; comparte como otras borrelias y espiroquetas su afinidad por el sistema nervioso central y el sistema nervioso periférico, y se convierte en un diagnóstico de exclusión optimista en Neurología. Conocer sus vectores, su distribución geográfica y algunas de las características biológicas específicas de esta nueva especie de borrelia es de suma importancia para el médico práctico de este nuevo siglo, donde la inmunología y la biología molecular iluminan el oscuro camino de viejas y nuevas interrogantes


Objective: bearing in mind the risk posed by the presence of the vector of Lyme disease in Cuba, the authors have considered it necessary to carry out a review of the disease with the purpose of contributing updated information to specialists and health institutions involved in its surveillance and epidemiological control. Content: a discussion is presented of the history, microbiology, epizootiology and epidemiology of Lyme disease, as well as its clinical manifestations in the main domestic animal hosts. Conclusions: Lyme borreliosis is a new infectious disease. Like other borrelias and spirochetes, it has an affinity for the central nervous system and the peripheral nervous system, thus becoming a diagnosis of optimistic exclusion in neurology. Knowledge about the vectors, geographic distribution and some specific biological characteristics of this new borrelia species is crucial for practitioners of the 21st century, a time when immunology and molecular biology shed new light on old and new questions alike


Assuntos
Ixodes/patogenicidade , Doença de Lyme
18.
Medwave ; 12(5)jun. 2012. ilus
Artigo em Espanhol | LILACS | ID: lil-715805

RESUMO

Existe consenso médico sobre la necesidad de extraer las garrapatas durante las primeras 24 horas en las que el ácaro parasita al huésped, para evitar posibles complicaciones. El modo recomendado es la tracción suave del ácaro, ayudado por unas pinzas, sin retorcerlo ni asfixiarlo con agentes tóxicos, puesto que existe la posibilidad de que excrete sustancias portadoras de bacterias. El tiempo medio de la extracción completa se estima comprendido entre cuatro y cinco minutos. En los niños parasitados por garrapatas este tiempo puede ser excesivo cuando se precisa una inmovilización no consentida. Utilizando esta técnica el tiempo se reduce a segundos y la lesión ocasionada en la piel del paciente es mínima.


There is medical consensus on the need to remove the tick within 24 hours the mite parasites to the human host, to avoid possible complications. The preferred way is by gently traction the mite, aided by forceps without twisting or chokes with toxic agents, because of the possibility that the mite excretes bacteria mixed with substances. The average time of extraction is estimated between one or three minutes. In children parasitized by ticks this amount of time can be excessive when it’s necessary restraint without the consent of the minor. Using this technique we reduce the time to seconds and the damage caused to the skin is minimal.


Assuntos
Humanos , Masculino , Feminino , Criança , Doença de Lyme/prevenção & controle , Carrapatos , População Rural
19.
Acta méd. costarric ; 54(1): 55-58, ene.-mar. 2012. ilus
Artigo em Espanhol | LILACS | ID: lil-648443

RESUMO

Paciente masculino de 44 años de edad, vecino de Santa Teresa de Puntarenas con un cuadro agudo de fiebre, escalosfríos, artralgias intensas y malestar general; 15 días después de una picadura de garrapata. Se realizó inmunofluorescencia indirecta para Borrelia burgdorferi, cual fue positiva y el paciente mejoró con 14 días de tratamiento con doxiciclina. Se descartaron otras patologías infecciosas y no infecciosas, por lo que consideramos el caso como el primer caso autóctono de enfermedad de Lyme, EL, en Costa Rica.


Assuntos
Humanos , Masculino , Adulto , Doxiciclina , Técnica Indireta de Fluorescência para Anticorpo , Doença de Lyme , Infestações por Carrapato , Costa Rica
20.
Braz. j. infect. dis ; 16(1): 82-85, Jan.-Feb. 2012. ilus
Artigo em Inglês | LILACS | ID: lil-614556

RESUMO

Lyme disease has not been officially reported in Cuba. However, clinical cases have been serologically reported. Seroprevalence survey of Borrelia burgdorferi sensu stricto antibodies in humans in the country has not been conducted. OBJECTIVE: To estimate the prevalence of borrelial antibodies in inhabitants of a village with historically high level of tick infestation. METHODS: Serum specimens from 247 persons randomly selected from the population of the village were examined by IgG Western blot using B31 strain for estimating the prevalence of antibodies profile. RESULTS: A seroprevalence value interval (95 percent CI) of 0.6 percent-7.2 percent was estimated for the studied population. The prevalent borrelial protein bands on immunoblots were 41, 72, 90/93, 34, 47, 60, 58, 56, 65/66 and 31 kDa in a decreasing order of significance. CONCLUSION: These results support the previous serological findings, suggesting the presence of this borreliosis in Cuba.


Assuntos
Humanos , Anticorpos Antibacterianos/sangue , Borrelia burgdorferi/imunologia , Imunoglobulina G/sangue , Doença de Lyme/epidemiologia , Western Blotting , Cuba/epidemiologia , Immunoblotting , Doença de Lyme/diagnóstico , Prevalência , Estudos Soroepidemiológicos
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