Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 447
Filtrar
1.
Rev. argent. coloproctología ; 31(1): 2-7, mar. 2020. tab, ilus
Artigo em Espanhol | LILACS | ID: biblio-1100300

RESUMO

Introducción: El budding tumor (BT) es la presencia de células tumorales aisladas o en pequeños grupos situadas en el frente de invasión del tumor. Su hallazgo en alto grado es un factor de mal pronóstico independiente del cáncer colorrectal. El objetivo de este trabajo es determinar si el grado de BT está asociado con otros factores pronósticos del cáncer rectal. Material y métodos: Se incluyen las resecciones oncológicas de recto en el período 2013-2017. Los casos se agruparon según la densidad en la formación de los BT en 3 grupos, los de grado bajo, intermedio y alto. Se utilizó como valor estadístico el cálculo del odds ratio (OR). Resultados: Se analizaron las piezas de resección de 27 pacientes (15 mujeres y 12 hombres) con una media de edad de 68,4 años (40-86). Se calculó el OR para invasión ganglionar, vascular y recidiva en función del grado de budding tumoral. Discusión: Se observó una tendencia a la presencia de factores histológicos de mal pronóstico en relación al budding de alto grado, si bien el bajo número de casos no permitió demostrarlo en este estudio. Conclusiones: El análisis del grado de tumor budding es reproducible y podría ayudar a identificar pacientes con cáncer rectal de peor pronóstico. (AU)


Introduction: Tumor budding (BT) is defined as isolated or small groups of neoplastic cells located at the invasive front of the tumor. High-grade BT is a poor prognostic factor in colorectal cancer. Objective: To determine if the degree of BT is associated with other prognostic factors in rectal cancer. Materials and methods: Rectal oncological resections during the 2013-2017 period were included. Cases were stratified according to the density in the formation of BT in 3 groups: low, intermediate and high. The calculation of the odds ratio (OR) was used as a statistical value. Results: The resection specimens of 27 patients (15 women and 12 men) with a mean age of 68.4 years (40-86) were analyzed. OR for node metastases, vascular invasion and relapse was calculated according to tumor budding grade. Discussion: High-grade tumor budding seems to associate with the presence of poor prognostic factors. However, it was not possible to demonstrate it because of the small sample size. Conclusions: Tumor budding is a reproducible marker and could help to identify rectal cancer patients with a worse prognosis. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Retais/patologia , Adenocarcinoma/patologia , Invasividade Neoplásica/patologia , Invasividade Neoplásica/diagnóstico por imagem , Prognóstico , Neoplasias Retais/cirurgia , Adenocarcinoma/cirurgia , Análise Estatística , Estudos Retrospectivos , Seguimentos , Estadiamento de Neoplasias
2.
Acta cir. bras ; 34(4): e201900409, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1001084

RESUMO

Abstract Purpose: To analyze the preoperative serum matrix metalloproteinase-9 (MMP-9) levels and prognosis of patients with hilar cholangiocarcinoma (HC) undergoing radical resection. Methods: Preoperative serum MMP-9 levels in patients with HC undergoing radical resection were detected by enzyme-linked immunosorbent assay (ELISA). The ROC curve assay was used to analyze the preoperative serum MMP-9 level to determine the most valuable cut-off point. The relationship between MMP-9 and clinicopathological features of HC patients was analyzed. Kaplan-Meier method was used to analyze the prognostic factors, and COX regression model was used to analyze the independent risk factors affecting prognosis. Results: Preoperative serum MMP-9 levels were significantly elevated in the death patients compared with the survival patients. The most valuable cut-off point for preoperative serum MMP-9 for prognosis was 201.93 ng/mL. Preoperative serum MMP-9 was associated with Bismuth-Corlette classification) and lymph node metastasis. Kaplan-Meier analysis showed that MMP-9, Bismuth-Corlette classification, Lymph node metastasis, Portal vein invasion, Hepatic artery invasion, Liver invasion, Incised margin, and Preoperative biliary drainage were related to prognosis. Cox regression model confirmed that hepatic artery invasion, liver invasion, incised margin, and MMP-9 have the potential to independence predicate prognosis in HC patients. Conclusion: Preoperative serum MMP-9 has high predictive value for prognosis and is an independent influencing factor for the prognosis of patients with hilar cholangiocarcinoma.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Neoplasias dos Ductos Biliares/cirurgia , Neoplasias dos Ductos Biliares/sangue , Tumor de Klatskin/cirurgia , Tumor de Klatskin/sangue , Metaloproteinase 9 da Matriz/sangue , Período Pós-Operatório , Prognóstico , Valores de Referência , Fatores de Tempo , Neoplasias dos Ductos Biliares/mortalidade , Neoplasias dos Ductos Biliares/patologia , Ensaio de Imunoadsorção Enzimática , Análise Multivariada , Fatores de Risco , Curva ROC , Tumor de Klatskin/mortalidade , Tumor de Klatskin/patologia , Estimativa de Kaplan-Meier , Período Pré-Operatório , Invasividade Neoplásica
3.
An. bras. dermatol ; 93(3): 373-376, May-June 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-949874

RESUMO

Abstract: BACKGROUND: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. OBJECTIVE: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. METHODS: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. RESULTS: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses' median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. STUDY LIMITATIONS: Use of medical records as a source of data to the study. CONCLUSIONS: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Neoplasias Cutâneas/patologia , Sarda Melanótica de Hutchinson/patologia , Melanoma/patologia , Prognóstico , Neoplasias Cutâneas/mortalidade , Brasil/epidemiologia , Taxa de Sobrevida , Estudos Retrospectivos , Seguimentos , Sarda Melanótica de Hutchinson/mortalidade , Melanoma/mortalidade , Invasividade Neoplásica/patologia
4.
Electron. j. biotechnol ; 32: 13-18, Mar. 2018. ilus, graf
Artigo em Inglês | LILACS | ID: biblio-1022495

RESUMO

Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDH@Au) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications.


Assuntos
Neoplasias Gástricas/tratamento farmacológico , Doxorrubicina/administração & dosagem , Apoptose/efeitos dos fármacos , Nanopartículas/administração & dosagem , Antibióticos Antineoplásicos/administração & dosagem , Doxorrubicina/farmacologia , Ciclo Celular/efeitos dos fármacos , Western Blotting , Sistemas de Liberação de Medicamentos , Nanotecnologia , Linhagem Celular Tumoral , Microscopia Eletrônica de Transmissão , Proliferação de Células/efeitos dos fármacos , Endocitose/efeitos dos fármacos , Hidróxidos , Antibióticos Antineoplásicos/farmacologia , Invasividade Neoplásica/prevenção & controle
5.
Braz. j. med. biol. res ; 51(4): e6803, 2018. graf
Artigo em Inglês | LILACS | ID: biblio-889059

RESUMO

Propofol is an intravenous sedative hypnotic agent of which the growth-inhibitory effect has been reported on various cancers. However, the roles of propofol in endometrial cancer (EC) remain unclear. This study aimed to explore the effects of propofol on EC in vitro and in vivo. Different concentrations of propofol were used to treat Ishikawa cells. Colony number, cell viability, cell cycle, apoptosis, migration, and invasion were analyzed by colony formation, MTT, flow cytometry, and Transwell assays. In addition, the pcDNA3.1-Sox4 and Sox4 siRNA plasmids were transfected into Ishikawa cells to explore the relationship between propofol and Sox4 in EC cell proliferation. Tumor weight in vivo was measured by xenograft tumor model assay. Protein levels of cell cycle-related factors, apoptosis-related factors, matrix metalloproteinases 9 (MMP9), matrix metalloproteinases 2 (MMP2) and Wnt/β-catenin pathway were examined by western blot. Results showed that propofol significantly decreased colony numbers, inhibited cell viability, migration, and invasion but promoted apoptosis in a dose-dependent manner in Ishikawa cells. Moreover, propofol reduced the expression of Sox4 in a dose-dependent manner. Additionally, propofol significantly suppressed the proportions of Ki67+ cells, but Sox4 overexpression reversed the results. Furthermore, in vivo assay results showed that propofol inhibited tumor growth; however, the inhibitory effect was abolished by Sox4 overexpression. Moreover, propofol inhibited Sox4 expression via inactivation of Wnt/β-catenin signal pathway. Our study demonstrated that propofol inhibited cell proliferation, migration, and invasion but promoted apoptosis by regulation of Sox4 in EC cells. These findings might indicate a novel treatment strategy for EC.


Assuntos
Animais , Feminino , Apoptose/efeitos dos fármacos , Neoplasias do Endométrio/tratamento farmacológico , Hipnóticos e Sedativos/farmacologia , Propofol/farmacologia , Fatores de Transcrição SOXC/metabolismo , beta Catenina/metabolismo , Linhagem Celular Tumoral , Movimento Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Neoplasias do Endométrio/patologia , Camundongos Endogâmicos BALB C , Invasividade Neoplásica , Propofol/administração & dosagem , Ensaio Tumoral de Célula-Tronco , Proteínas Wnt/metabolismo , Ensaios Antitumorais Modelo de Xenoenxerto
6.
Braz. j. med. biol. res ; 51(6): e7046, 2018. graf
Artigo em Inglês | LILACS | ID: biblio-889094

RESUMO

Thyroid cancer is a common malignant tumor. Long non-coding RNA colon cancer-associated transcript 1 (lncRNA CCAT1) is highly expressed in many cancers; however, the molecular mechanism of CCAT1 in thyroid cancer remains unclear. Hence, this study aimed to investigate the effect of CCAT1 on human thyroid cancer cell line FTC-133. FTC-133 cells were transfected with CCAT1 expressing vector, CCAT1 shRNA, miR-143 mimic, and miR-143 inhibitor, respectively. After different treatments, cell viability, proliferation, migration, invasion, and apoptosis were measured. Moreover, the regulatory relationship of CCAT1 and miR-143, as well as miR-143 and VEGF were tested using dual-luciferase reporter assay. The relative expressions of CCAT1, miR-143, and VEGF were tested by qRT-PCR. The expressions of apoptosis-related factors and corresponding proteins in PI3K/AKT and MAPK pathways were analyzed using western blot analysis. The results suggested that CCAT1 was up-regulated in the FTC-133 cells. CCAT1 suppression decreased FTC-133 cell viability, proliferation, migration, invasion, and miR-143 expression, while it increased apoptosis and VEGF expression. CCAT1 might act as a competing endogenous RNA (ceRNA) for miR-143. Moreover, CCAT1 activated PI3K/AKT and MAPK signaling pathways through inhibition of miR-143. This study demonstrated that CCAT1 exhibited pro-proliferative and pro-metastasis functions on FTC-133 cells and activated PI3K/AKT and MAPK signaling pathways via down-regulation of miR-143. These findings will provide a possible target for clinical treatment of thyroid cancer.


Assuntos
Humanos , MicroRNAs/metabolismo , RNA Longo não Codificante/metabolismo , Neoplasias da Glândula Tireoide/patologia , Apoptose , Linhagem Celular Tumoral , Movimento Celular , Proliferação de Células , Sobrevivência Celular , Regulação para Baixo , Regulação Neoplásica da Expressão Gênica , MicroRNAs/genética , Invasividade Neoplásica/patologia , RNA Longo não Codificante/genética , Transfecção
7.
Braz. j. med. biol. res ; 51(4): e6867, 2018. graf
Artigo em Inglês | LILACS | ID: biblio-889068

RESUMO

Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wound healing assay were performed to determine cell proliferation, invasion and migration. Flow cytometry and TUNEL assay were used to measure cell apoptosis. Quantitative real-time PCR and western blotting assays were used to determine mRNA and protein expression levels. Xenograft experiment was performed to determine the in vivo anti-tumor effect of polydatin. Immunostaining was performed to analyze the expression of caspase-3 and Ki-67. Our results showed that polydatin inhibited cell proliferation in a concentration-dependent and time-dependent manner in the HCC cell lines. Polydatin also induced cell apoptosis in a concentration-dependent manner possibly via increasing the caspase-3 activity, and up-regulating the protein expression of caspase-3, caspase-9, Bax, and down-regulating the protein expression of Bcl-2. In addition, polydatin treatment had an inhibitory effect on cell proliferation, invasion and migration in HCC cell lines. Polydatin treatment also suppressed the Wnt/beta-catenin signaling activities in HCC cells. Polydatin treatment significantly reduced tumor growth in nude mice inoculated with HepG2 cells, suppressed the expression of Ki-67, and increased caspase-3 expression and TUNEL activity. Our data indicated the important role of polydatin for the suppression of HCC progression.


Assuntos
Animais , Masculino , Camundongos , Estilbenos/farmacologia , Movimento Celular/efeitos dos fármacos , Apoptose/efeitos dos fármacos , Carcinoma Hepatocelular/tratamento farmacológico , Proliferação de Células/efeitos dos fármacos , Glucosídeos/farmacologia , Neoplasias Hepáticas Experimentais/tratamento farmacológico , Medicamentos de Ervas Chinesas , Western Blotting , Carcinoma Hepatocelular/patologia , Linhagem Celular Tumoral , Reação em Cadeia da Polimerase em Tempo Real , Citometria de Fluxo , Neoplasias Hepáticas Experimentais/patologia , Camundongos Endogâmicos BALB C , Camundongos Nus , Invasividade Neoplásica
8.
Rev. argent. urol. (1990) ; 83(4): 138-144, 2018. graf
Artigo em Espanhol | LILACS | ID: biblio-987907

RESUMO

Introducción: El cáncer de pene tiene una alta incidencia en Latinoamérica, siendo el carcinoma epidermoide el tipo histológico más frecuente. También es sabido que el cáncer de pene suele presentar diseminación a los ganglios linfáticos inguinales, antes de la progresión a la enfermedad metastásica. Objetivo: Caracterizar a los pacientes tratados por cáncer de pene con invasión locorregional en el Servicio de Urología del Hospital Central del Instituto de Previsión Social (HCIPS) de Asunción del Paraguay. Materiales y métodos: Se realizó un estudio retrospectivo, de pacientes tratados con cáncer de pene con invasión locorregional entre los años 2014 y 2017. Se analizaron las siguientes variables: estadificación, tratamientos empleados según la clasificación y complicaciones. Resultados: Los 18 pacientes tratados por cáncer de pene con invasión locorregional fueron adultos mayores, con una edad media de 78,5 años. El tipo de intervención más frecuente fue la linfadenectomía inguinal bilateral (44%). Solo cuatro pacientes fueron sometidos simultáneamente a penectomía y linfadenectomía. Las complicaciones posoperatorias se presentaron en 8 casos (44%), siendo el linfedema la más frecuente. Conclusiones: Los factores pronósticos adversos más importantes son la presencia de adenopatías, el estadío clínico al diagnóstico y el grado de diferenciación celular. El tratamiento más eficaz del cáncer de pene es quirúrgico, reservando la quimioterapia y la radioterapia para adyuvancia o terapia de rescate, siendo las complicaciones más graves, mientras más radical sea la cirugía.(AU)


Introduction: Penile cancer has a high incidence in Latin America, with squamous cell carcinoma being the most frequent histological type. It is also known that penile cancer has a spread to the inguinal lymph nodes, before the progression to metastatic disease. Objective: Characterize the patients treated for penile cancer with locoregional invasion in the Urology Service of the Hospital Central del Instituto de Previsión Social (HCIPS), Asunción of Paraguay. Materials and methods: A retrospective study was conducted of patients treated with penile cancer with locoregional invasion between 2014 and 2017. The following variables were analyzed: staging, treatments used according to the classification and complications. Results: The 18 patients treated for penile cancer with locoregional invasion were older adults, with an average age of 78.5 years. The most frequent type of intervention was the bilateral ilioinguinal (44%). Only four patients were subjected simultaneously to penectomy and lymphadenectomy. Postoperative complications occurred in 8 cases (44%), lymphedema being the most frequent. Conclusions: The most important adverse prognostic factors are the presence of adenopathies, the clinical stage at diagnosis and the degree of cell differentiation. The most effective treatment of penile cancer is surgical, reserving chemotherapy and radiotherapy for adjuvance or rescue therapy, being the complications more serious, the more radical the surgery is.(AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Neoplasias Penianas/cirurgia , Neoplasias Penianas/complicações , Neoplasias Penianas/diagnóstico , Neoplasias Penianas/epidemiologia , Excisão de Linfonodo , Linfonodos/cirurgia , Estudos Transversais , Estudos Retrospectivos , Estudo Observacional , Canal Inguinal , Linfonodos/patologia , Invasividade Neoplásica , Estadiamento de Neoplasias
9.
São Paulo; s.n; s.n; 2018. 105 p. ilus, tab, graf.
Tese em Inglês | LILACS | ID: biblio-909445

RESUMO

Chromatin remodeler proteins exert an important function in promoting dynamic modifications in the chromatin architecture, rendering the transcriptional machinery available to the condensed genomic DNA. Due to this central role in regulating gene transcription, deregulation of these molecular machines may lead to severe perturbations in the normal cell functions. Loss-of-function mutations in the CHD7 gene, a member of the chromodomain helicase DNA-binding (CHD) family, are the major cause of the CHARGE syndrome in humans. The disease is characterized by a variety of congenital anomalies, including malformations of the craniofacial structures, peripheral nervous system, ears, eyes and heart. In this context, several studies have already shown the importance of CHD7 for proper function of the neural stem cells (NSCs). Interestingly, we found that CHD7 mRNA levels are upregulated in gliomas, when compared to normal brain tissue, therefore, we hypothesized that CHD7 might have a role in the pathogenesis of these tumors. To investigate the possible oncogenic role of CHD7 in glioblastoma (GBM), we adopted gain- and loss-of-function approaches in adherent GBM cell lines. Using CRISPR_Cas9 genome editing, we found that CHD7 deletion suppresses anchorage-independent growth and reduces spheroid invasion in human LN-229 cells. Moreover, deletion of CHD7 delayed tumor growth and improved overall survival in an orthotopic xenograft glioma mouse model. Conversely, ectopic overexpression of CHD7 in LN-428 and A172 cells was found to increase cell motility and invasiveness in vitro and LN-428 tumor growth in vivo. RNAseq analysis showed that alterations of CHD7 expression levels promote changes in several molecular pathways and modulate critical genes associated with cell adhesion and locomotion. However, the mechanisms underlying the effects of CHD7 overexpression in glioma tissue are still not understood. Here, we also generated recombinant plasmid with functional CHD7 promoter activity reported by luciferase assay. This powerful tool should enable future studies to determine the direct targeting relationship between different signal transduction pathways and CHD7 geneexpression. In summary, our findings indicate that GBM cells expressing a high level of CHD7 may exist and contribute to tumor infiltration and recurrence. Further studies should warrant important clinical-translational implications of our findings for GBM treatment


As proteínas remodeladoras de cromatina exercem importante papel, promovendo modificações dinâmicas na arquitetura da cromatina e dando acesso à maquinaria transcricional ao DNA genômico condensado. Devido à esta função central na regulação da transcrição gênica, a desregulação dessas máquinas moleculares pode levar a perturbações graves na função normal das células. Assim, por exemplo, mutações do tipo perda de função no gene CHD7, um membro da família "chromodomain helicase DNA-binding" (CHD), são a principal causa da síndrome de CHARGE em humanos. A doença é caracterizada por uma variedade de anomalias congênitas, incluindo malformações das estruturas craniofaciais, sistema nervoso periférico, orelhas, olhos e coração. Neste contexto, vários estudos já mostraram a importância da proteína CHD7 para o funcionamento normal de células-tronco neurais (NSCs). Curiosamente, descobrimos que os níveis de mRNA de CHD7 estão mais fortemente expressos em gliomas, quando comparados ao tecido cerebral normal, portanto, nós hipotetizamos que CHD7 poderia ter um papel na patogênese desses tumores. Para investigar o possível papel oncogênico de CHD7 em glioblastoma (GBM), utilizamos enfoques de ganho e perda de função em linhagens celulares aderentes de GBM. Utilizando a técnica de CRISPR_Cas9 para edição do genoma, demonstramos que a deleção do gene CHD7 suprime o crescimento independente de ancoragem e reduz a invasão de esferóides em células LN-229 humanas de GBM. Além disso, a deleção de CHD7 reduziu o crescimento do tumor e melhorou a sobrevida em modelo de injeção ortotópica xenográfica em camundongo. Por outro lado, verificou-se que a super-expressão ectópica de CHD7 nas células LN-428 e A172 aumenta não só a motilidade celular e a capacidade de invasão in vitro, mas, também, o crescimento do tumor de LN-428 in vivo. A análise de RNA-seq mostrou que o nocauteamento da sequência codificadora de CHD7 e sua super-expressão promovem alterações em diversas vias moleculares, modulando genes críticosassociados à adesão e locomoção celular. No entanto, os mecanismos subjacentes aos efeitos da super-expressão de CHD7 em tecidos de glioma ainda não são compreendidos. Neste trabalho, geramos um plasmídeo recombinante contendo um fragmento da região promotora de CHD7, o qual se mostrou funcional em ensaios de luciferase. Esta ferramenta permitirá que estudos futuros possam identificar a relação direta entre as diferentes vias de transdução de sinal e a expressão do gene CHD7. Em resumo, nossos achados indicam que células de GBM expressando um alto nível de CHD7 podem existir e contribuir para a infiltração e recorrência do tumor. Estudos posteriores deverão avaliar as possíveis implicações dos resultados apresentados neste trabalho para a translação clínica no tratamento de pacientes com GBM


Assuntos
Montagem e Desmontagem da Cromatina , Glioblastoma/complicações , Movimento Celular/fisiologia , Invasividade Neoplásica
11.
Int. j. morphol ; 35(2): 733-739, June 2017. ilus
Artigo em Inglês | LILACS | ID: biblio-893047

RESUMO

Although, antineoplastic therapies have now been developed reduction of tumor progression,itis necessarytofind new therapeutic alternatives to suppress angiogenesis.Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor modelinduced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferationinaddition to increased apoptosis (P <0.0001). Cx reduces tumor progression in a concentration of 1000 ppm associated with PLGA, reducing cell proliferation, the presence of VEGF and promoting apoptosis of multiresistant TA3 tumor cells.


Si bien actualmente se han desarrollado terapias antineoplásicas que permiten reducir de cierta manera el avance tumoral, es necesario buscar nuevas alternativas terapéuticas que permitan suprimir la angiogénesis. Es así como el Celecoxib (Cx) ha sido utilizado por su acción antiangiogénica en combinación con algunos compuestos poliméricos, tal como el ácido poli (láctico co-glicólico) (PLGA), el cual ayudaría a mejorar la biodisponibilidad y evitaría efectos derivados de largas administraciones del fármaco. Para tal efecto se ha utilizado un modelo tumoral murino, inducido por células tumorales de adenocarcinoma mamario resistente a la quimioterapia (TA3-MTXR). Los resultados indican que CX/PLGA inhibe la microvascularización, expresión de VEGF y la proliferación celular además del aumento de la apoptosis (P<0,0001). El efecto antitumoral del Cx está bien reportado en la literatura; este sumado a la microencapsulación con PLGA, aportarían un sistema de administración útil, ya que nos otorga una administración sostenida en el tiempo, los cual podría ayudar a mantener los niveles de droga durante un período más prolongado, lo cual sería beneficioso en la terapia tumoral.


Assuntos
Animais , Feminino , Camundongos , Antineoplásicos/administração & dosagem , Celecoxib/administração & dosagem , Neovascularização Patológica/tratamento farmacológico , Apoptose/efeitos dos fármacos , Linhagem Celular Tumoral/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Sistemas de Liberação de Medicamentos , Imuno-Histoquímica , Ácido Láctico/administração & dosagem , Invasividade Neoplásica/prevenção & controle , Ácido Poliglicólico/administração & dosagem , Polímeros/administração & dosagem , Fator A de Crescimento do Endotélio Vascular/efeitos dos fármacos
12.
J. appl. oral sci ; 25(3): 318-323, May-June 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-893624

RESUMO

Abstract Objectives To evaluate the number of AgNORs per nucleus and the expression of Ki-67 at the tumor invasion front (TIF) in relation to clinical parameters (TNM), TIF classification and the prognosis of oral squamous cell carcinomas in an Uruguayan population. Material and Methods This study was conducted through a retrospective survey from 2000 to 2010 at the National Institute of Cancer Montevideo, Uruguay and included 40 patients. The samples were obtained from the resection of the tumor and the TIF was defined according with Bryne, et al.5 (1992). Expression of Ki-67 was assessed by the percentage of positive tumor cells and the AgNOR was recorded as the mean AgNOR (mAgNOR) and the percentage of AgNOR per nucleus (pAgNOR). All analyzes were performed by a blinded and calibrated observer. Results No statistically significant association was observed between immunostaining of Ki-67 and AgNOR with the different types of TIF, regional metastasis and patients prognosis, however it was observed an increase in Ki-67 expression associated with worse patient's clinical staging, although not statistically significant. Conclusions Our results suggest that proliferation markers as AgNOR and Ki-67 are not prognostic markers at the tumor invasive front of carcinoma of oral squamous cell.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Antígenos Nucleares/análise , Carcinoma de Células Escamosas/patologia , Neoplasias Bucais/patologia , Análise de Variância , Biomarcadores Tumorais , Proliferação de Células , Imuno-Histoquímica , Antígeno Ki-67/análise , Invasividade Neoplásica/patologia , Prognóstico , Valores de Referência , Reprodutibilidade dos Testes , Estudos Retrospectivos , Carga Tumoral , Uruguai
13.
Clinics ; 72(5): 258-264, May 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-840078

RESUMO

OBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with primary colorectal cancer selected for multivisceral resection were identified from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcomes were obtained from medical records. Estimated local recurrence and overall survival were compared using the log-rank method, and Cox regression analysis was used to determine the independence of the studied parameters. ClinicalTrials.gov: NCT02859155. RESULTS: The median age of the patients was 60 (range 23-86) years, 66.7% were female, 80% of tumors were located in the rectum, 11.4% had stage-IV disease, and 54.3% received neoadjuvant chemoradiotherapy. The organs most frequently resected were ovaries and annexes (37%). Additionally, 30.5% of patients received abdominoperineal resection. Invasion of other organs was confirmed histologically in 53.5% of patients, and R0 resection was obtained in 72% of patients. The overall morbidity rate of patients in this study was 37.1%. Ureter resection and intraoperative blood transfusion were independently associated with an increased number of complications. The 30-day postoperative mortality rate was 1.9%. After 27 (range 5-57) months of follow-up, the mortality and local recurrence rates were 23% and 15%, respectively. Positive margins were associated with a higher recurrence rate. Positive margins, lymph node involvement, stage III/IV disease, and stage IV disease alone were associated with lower overall survival rates. On multivariate analysis, the only factor associated with reduced survival was lymph node involvement. CONCLUSIONS: Multivisceral en bloc resection for primary colorectal cancer can be performed with acceptable rates of morbidity and mortality and may lead to favorable oncological outcomes.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Adulto Jovem , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/cirurgia , Neoplasias Colorretais/patologia , Complicações Intraoperatórias , Estimativa de Kaplan-Meier , Morbidade , Terapia Neoadjuvante , Invasividade Neoplásica , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Complicações Pós-Operatórias , Prognóstico , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo , Vísceras/patologia , Vísceras/cirurgia
14.
Oncol. (Guayaquil) ; 27(1): 21-31, 15 de abril 2017.
Artigo em Espanhol | LILACS | ID: biblio-997505

RESUMO

Introducción: El reservorio ilealcon anastomosis reservorio-anal (RIARA) es un procedimiento de reconstrucción del tránsito intestinal que se realiza luego de una proctectomía y trata de simular la funcionalidad de la ampolla rectal para disminuir los episodios de incontinencia. El objetivo del presente estudio fue describir las complicaciones perioperatorias del procedimiento y los resultados funcionales a un año. Métodos:El presente estudio observacional es una revisión de expedientes de pacientes a quienes se realizó RIARA entre julio del 2014 y septiembre del 2016, en el servicio de cirugía de la Clínica Guayaquil. La muestra fue no probabilística por conveniencia. Se incluyeron todos los pacientes a los que se realizó una coloproctectomía. Se midieron las complicaciones tempranas mediante la escala de Clavien-Dindo. Los resultados funcionales al año de la cirugía se valoraron con el test de Öresland. Se utilizó estadística descriptiva. Resultados: Se incluyeron 45 casos (35 hombres y 10 mujeres, media de edad 55 años), que se realizaron coloproctectomía: 8 casos por Poliposis Adenomatosa Familiar (PAF), 3 por Colitis Ulcerosa (CU) y 34 por cáncer colorrectal. Las complicaciones se presentaron en 18 pacientes (40 %): 12 casos (26.7 %) con trastornos hidroelectrolíticos, 3 colecciones pélvicas (6.7 %), 1 que requirió reintervención y 1 con drenaje prolongado. Complicaciones de Nivel II 83.33 %. La media de evacuaciones fue de 5 en 24 horas a los tres primeros meses. Puntaje Öresland de 0 a 3 puntos, en 34 pacientes (80 %) al año. Conclusiones: En la presente serie se muestran buenos resultados funcionales al año del procedimiento de RIARA, morbilidad de nivel III aceptable y sin mortalidad en este reporte. Es necesario el seguimiento a largo plazo para identificar complicaciones tardías.


Introduction: The ilealreservoir with anal-reservoir anastomosis (IRARA) is a procedure of intestinal transit reconstruction that is performed after a proctectomy and tries to simulate the functionality of the rectal ampulla to reduce episodes of incontinence. The aim of the present study was to describe the perioperative complications of the procedure and the functional results at 1 year. Methods:The present observational study is a review of IRARA patient records, between July 2014 and September 2016, in the Surgery service of the "Clínica-Guayaquil". The sample was non-probabilistic for convenience. All patients underwent a coloproctectomy. Early complications were measured using the Clavien-Dindo scale. Functional results one year after surgery were assessed with the Öresland test. Descriptive statistics is used. Results: 45 cases were included (35 men and 10 women), average age was 55 years, who underwent coloproctectomy, 8 cases for Familial Adenomatose Polyposis, 3 for Ulcerative Colitis and 34 for colorectal cancer. Complications occurred in 18 patients (40%), 12 cases (26.7%) with Hydro-electrolyte disorders, 3 pelvic collections 1 requiring reoperation and 1 with prolonged drainage. Complications of Level II 83.33%. The average of evacuations was 5 in 24 hours in the first three months. Öresland score from 0 to 3 points, in 34 patients (80%) per year. Conclusions: The results of this series show good functional results at one year of the IRARA procedure, morbidity of level III acceptable and without mortality in this report. Long-term follow-up is necessary to identify late complications


Assuntos
Humanos , Invasividade Neoplásica
15.
Rev. Col. Bras. Cir ; 44(2): 163-170, Mar.-Apr. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-842661

RESUMO

ABSTRACT Objective: to analyze the relation of anatomopathological features and axillary involvement in cases of invasive ductal carcinoma. Methods: this is a cross-sectional study of 220 breast cancer patients submitted to radical mastectomy or quadrantectomy with axilar emptying, from the Mastology Service of the Assis Chateaubriand Maternity School, Ceará, Brazil. We submitted the tumors to histological processing and determined the histological (HG), tubular (TG) and nuclear (NG) grades, and the mitotic index (MI) by the classification of Scarff-Bloom-Richadson, verified the presence of angiolymphatic invasion (AI) and measured the largest tumor diameter (TD). We then correlated these variables with the presence of axillary metastases. Results: the mean patients'age was 56.81 years ± 13.28. Tumor size ranged from 0.13 to 22 cm, with an average of 2.23cm ± 2.79. HG3, TG3 and NG3 prevailed, respectively 107 (48.6%), 160 (72.7%) and 107 (48.6%). Mitotic indexes 1, 2 and 3 presented a homogeneous distribution, respectively 82 (37.2%), 68 (31%) and 70 (31.8%). We observed no relation between the HG, TG and NG with the occurrence of axillary metastases (p=0.07, p=0.22 and p=0.21, respectively). Mitotic indices 2 and 3 were related with the occurrence of axillary metastases (p=0.03). Tumors larger than 2cm and cases that presented angiolymphatic invasion had a higher index of axillary metastases (p=0.0003 and p<0.0001). Conclusion: elevated mitotic indexes, tumors with a diameter greater than 2cm and the presence of angiolymphatic invasion were individuallyassociatedwith the occurrence of axillary metastases.


RESUMO Objetivo: analisar a relação das características anatomopatológicas com o comprometimento axilar em casos de carcinoma ductal invasor. Métodos: estudo transversal de 220 pacientes com câncer de mama, submetidas à mastectomia radical ou quadrantectomia com esvaziamento axilar, oriundos do Serviço de Mastologia da Maternidade Escola Assis Chateaubriand, Ceará, Brasil. Os tumores foram submetidos a processamento histológico e, em seguida, foram determinados os graus histológico (GH), tubular (GT), nuclear (GN), índice mitótico (IM) pela classificação de Scarff-Bloom-Richadson, verificada a presença de invasão angiolinfática (IA) e mensurado o maior diâmetro do tumor (DT). Tais variáveis foram correlacionadas com a presença de metástases axilares. Resultados: a média de idade das pacientes foi 56,81 anos ± 13,28. O tamanho do tumor variou de 0,13 a 22 cm, com média de 2,23cm ± 2,79. Os GH3, GT3 e GN3 prevaleceram: n=107 (48,6%), n=160 (72,7%) e n=107 (48,6%), respectivamente. Os índices mitóticos 1, 2 e 3 apresentaram distribuição homogênea: n=82 (37,2%), n=68 (31%) e n=70 (31,8%), respectivamente. Não foi evidenciada relação do GH, GT e GN com a ocorrência de metástases axilares (p=0,07; p=0,22 e p=0,21). Índices mitóticos 2 e 3 apresentaram relação com a o ocorrência de metástases axilares (p=0,03). Tumores maiores do que 2cm e casos com invasão angiolinfática apresentaram maior índice de metástases axilares (p=0,0003 e p<0,0001). Conclusão: índices mitóticos elevados, tumores com diâmetro maior do que 2cm e presença de invasão angiolinfática apresentaram isoladamente relação com a ocorrência de metástases axilares.


Assuntos
Humanos , Feminino , Adulto , Idoso , Idoso de 80 Anos ou mais , Axila , Neoplasias da Mama/patologia , Carcinoma Ductal/patologia , Carcinoma Ductal/secundário , Estudos Transversais , Pessoa de Meia-Idade , Invasividade Neoplásica
16.
Oncol. (Guayaquil) ; 27(1): 55-65, 15 de abril 2017.
Artigo em Espanhol | LILACS | ID: biblio-998413

RESUMO

Introducción: La radioterapia externa con dosis altas, ha incrementado el efecto terapéutico en Gliomas Anaplásicos. El propósito de nuestro estudio fue demostrar la eficacia de la radioterapia conformada tridimensional con altas dosis en estos pacientes. Métodos: Estudio retrospectivo-prospectivo y descriptivo realizado en 45 pacientes adultos con diagnóstico de Glioma de alto grado supratentorial, índice de Karnofsky ≥ 70, sin previa quimioterapia o inmunoterapia; con exéresis quirúrgica y radioterapia postoperatoria estándar bidimensional óconformada tridimensional en el Instituto de Oncología de Cuba del 2004-2007. Se excluyeron los casos no operados. Se utilizó Kaplan Meier y regresión de Cox entre las variables. Resultados: La edad promedio fue 55 años, relación sexo hombre/mujer fue 27/18 y el Glioblastoma resultóla histología más frecuente. Predominóla exéresis subtotal del tumor y radioterapia postoperatoria con dosis entre 60-70 Gy. La supervivencia fue mayor en pacientes con mejor pronóstico, resección tumoral total y radioterapia con altas dosis. La supervivencia global fue de 13 meses y la media (Kaplan-Meier) fue significativamente mejor en los pacientes con dosis altas de radioterapia tridimensional (16 vs 9 meses) P<0.001. La supervivencia a 1 y 2 años, fue del 51 % y 28 % respectivamente en el grupo de altas dosis, asícomo del 28% y 16% respectivamente en el grupo de dosis estándar, sin evidenciarse un incremento en las toxicidades. Conclusiones: La intensificación de la radioterapia local con escalada de dosis es recomendable para los pacientes con Gliomas de alto grado y factores pronósticos favorables


Introduction: High-dose with external beam radiotherapy has been shown to enhance the radiation effect in anaplastic gliomas. The aim of this trial is to report on the efficacy of 3D conformal radiotherapy (3D-CRT) for patients with intracranial malignant gliomas. Methods: A retrospective-prospective and descriptive study was made from 45 patients with supratentorial high-grade gliomas,Karnofsky performance scale ≥ 70, no previous chemotherapy/ immunotherapy treatment, who received postoperative 2D standard or 3D-CRTat the Oncology Institute of Cuba from 2004-2007. Results: The median age of patients was 55 years, gender (M/F:27/18). Glioblastoma histology, subtotal resection, and postoperative radiotherapy (60-70Gy) were the most frequently. The survival time was much better in patients who were better prognosis, gross total resection and high-dose 3D-CRT postoperatively .The overall survival was 13 months and the estimated median survival (Kaplan-Meier) was better in high-dose group (16 vs 9 months), and the 1 and 2 yearssurvival rates were 51% & 28%, respectively for 3D-CRT group; and 28% & 16% for 2D-RT. No significant treatment toxicities were observed. Conclusions: Intensification of local radiotherapy with dose escalation is feasible for patients with high-grade gliomas and good prognostic factors.


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Neoplasias do Sistema Nervoso Central , Glioma , Segunda Neoplasia Primária , Invasividade Neoplásica
17.
Clinics ; 72(1): 30-35, Jan. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-840034

RESUMO

OBJECTIVES: To evaluate the postoperative pathological characteristics of hysterectomy specimens, preoperative cancer antigen (CA)-125 levels and imaging modalities in patients with endometrial cancer and to build a risk matrix model to identify and recruit patients for retroperitoneal lymphadenectomy. METHODS: A total of 405 patients undergoing surgical treatment for endometrial cancer were retrospectively reviewed and analyzed. Clinical (age and body mass index), laboratory (CA-125), radiological (lymph node evaluation), and pathological (tumour size, grade, lymphovascular space invasion, lymph node metastasis, and myometrial invasion) parameters were used to test the ability to predict lymph node metastasis. Four parameters were selected by logistic regression to create a risk matrix for nodal metastasis. RESULTS: Of the 405 patients, 236 (58.3%) underwent complete pelvic and para-aortic lymphadenectomy, 96 (23.7%) underwent nodal sampling, and 73 (18%) had no surgical lymph node assessment. The parameters predicting nodal involvement obtained through logistic regression were myometrial infiltration >50%, lymphovascular space involvement, pelvic lymph node involvement by imaging, and a CA-125 value >21.5 U/mL. According to our risk matrix, the absence of these four parameters implied a risk of lymph node metastasis of 2.7%, whereas in the presence of all four parameters the risk was 82.3%. CONCLUSION: Patients without deep myometrial invasion and lymphovascular space involvement on the final pathological examination and with normal CA-125 values and lymph node radiological examinations have a relatively low risk of lymph node involvement. This risk assessment matrix may be able to refer patients with high-risk parameters necessitating lymphadenectomy and to decide the risks and benefits of lymphadenectomy.


Assuntos
Humanos , Feminino , Adulto , Idoso , Antígeno Ca-125/sangue , Neoplasias do Endométrio/patologia , Metástase Linfática/diagnóstico , Neoplasias do Endométrio/cirurgia , Excisão de Linfonodo , Metástase Linfática/prevenção & controle , Invasividade Neoplásica , Valor Preditivo dos Testes , Estudos Retrospectivos , Fatores de Risco
18.
Braz. j. med. biol. res ; 50(7): e6011, 2017. graf
Artigo em Inglês | LILACS | ID: biblio-839318

RESUMO

Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological functions, such as muscle contraction, cell volume regulation, immune response and cell proliferation. In breast cancer, different types of ion channels have been associated with tumorigenesis. Recently, voltage-gated Na+ channels (VGSC) have been implicated in the processes that lead to increased tumor aggressiveness. To explain this relationship, different theories, associated with pH changes, gene expression and intracellular Ca2+, have been proposed in an attempt to better understand the role of these ion channels in breast cancer. However, these theories are having difficulty being accepted because most of the findings are contrary to the present scientific knowledge. Several studies have shown that VGSC are related to different types of cancer, making them a promising pharmacological target against this debilitating disease. Molecular biology and cell electrophysiology have been used to look for new forms of treatment aiming to reduce aggressiveness and the disease progress.


Assuntos
Humanos , Feminino , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Regulação Neoplásica da Expressão Gênica , Canais de Sódio Disparados por Voltagem/metabolismo , Invasividade Neoplásica , Metástase Neoplásica
19.
MedUNAB ; 20(1): 63-69, 2017. tab, graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-878015

RESUMO

Introduction: Malignant pericardial effusion is the accumulation of liquid in the pericardial space secondary to advanced stage neoplasia, becoming in an indicator of bad prognosis. Malignant tumors that are most often related to this entity are the ones from pulmonary, mammary, and hematolymphoid origin. Clinically, it may present imminent signs of cardiac tamponade and hemodynamic instability, so that it merits an early diagnosis and management with emerging decompression maneuvers. Objective: This article presents a malignant pericardial effusion case, since this clinical condition implies a diagnostic challenge. Case presentation and Conclusions: A case of a 63 year old male patient is presented. He has one month of clinical evolution characterized by cervical adenopathies, also in the past fifteen days has been presenting precocious satiety, nocturnal sweating, sensation of distended abdomen, and functional class deterioration to having dyspnea during small physical efforts. This was the reason why he went to the emergency room. During the medical observation, the patient quickly deteriorates to hemodynamic instability, refractory to treatment. Some imaging studies were performed, which show severe pericardial effusion so a decompressive pericardiocentesis and a multidisciplinary integral management were performed...(AU)


Introducción: El derrame pericárdico maligno es la acumulación de líquido en el espacio pericárdico secundario a neoplasias en estadios avanzados, siendo así, un indicador de mal pronóstico. Los tumores malignos que con mayor frecuencia se relacionan con esta entidad son los de origen pulmonar, mamario y hematolinfoides. Clínicamente puede cursar con signos inminentes de taponamiento cardiaco e inestabilidad hemodinámica, por lo que amerita un diagnóstico temprano y manejo urgente con maniobras de descompresión. Objetivo: Este articulo busca presentar un caso de derrame pericárdico maligno, debido a que esta condición clínica implica un reto diagnóstico. Presentación del caso y conclusiones: Presentamos el caso de un paciente masculino de 63 años de edad, con cuadro clínico de 1 mes de evolución, caracterizado por presencia de adenopatías cervicales, quien en los últimos 15 días presenta saciedad precoz, sudoración nocturna, sensación de distensión abdominal y deterioro de la clase funcional hasta disnea de pequeños esfuerzos, motivo por el cual consulta al servicio de urgencias. Durante la observación médica rápidamente progresa a inestabilidad hemodinámica, refractaria a manejo; se realizan estudios imagenológicos, en donde se evidencia derrame pericárdico severo, por lo que se procede a realizar pericardiocentesis descompresiva emergente y manejo integral multidisciplinario...(AU)


Introdução: o derrame pericárdico maligno é o acúmulo de líquido no espaço pericárdico secundário a neoplasias em estádios avançados, sendo, portanto, um indicador de mau prognóstico. Os tumores malignos, frequentemente associados a esta categoría, são aqueles de origem pulmonar, mamária e hematolinfóides. Clinicamente, podem apresentar sinais iminentes de tamponamento cardíaco e instabilidade hemodinâmica, o que justifica um diagnóstico precoce e tratamento urgente com manejo de descompressão. Objetivo: Este artigo tem como objetivo apresentar um caso de derrame pericárdico maligno, pois esta condição clínica implica um desafio diagnóstico. Apresentação e conclusões do caso: apresentamos o caso de um paciente do sexo masculino de 63 anos, com o quadro clínico de 1 mês de evolução, caracterizado pela presença de linfadenopatia cervical, que nos últimos 15 dias apresenta saciedade precoce, sudação noturna, distensão abdominal e deterioração da classe funcional até a dispnéia de pequenos esforços, motivo pelo qual consulta o serviço de emergência. Durante a observação médica, ele progride rapidamente para a instabilidade hemodinâmica, refratária ao manejo; Estudos de imagem são realizados, nos quais o derrame pericárdico grave é evidente, por isso é necessário realizar pericardiocentese descompressiva emergente e gerenciamento integral multidisciplinar...(AU)


Assuntos
Humanos , Derrame Pericárdico , Tamponamento Cardíaco , Neoplasias Pulmonares , Pericardiocentese , Invasividade Neoplásica
20.
An. bras. dermatol ; 91(1): 73-79, Jan.-Feb. 2016. graf
Artigo em Inglês | LILACS | ID: lil-776425

RESUMO

Abstract In Brazil, without considering the non-melanoma skin tumors, bladder cancer in men is the eighth most common, and the urothelial carcinoma or transitional cell carcinoma is the most common among these. Cutaneous metastases from urothelial neoplasms appear as single or multiple erythematous, infiltrated nodules or plaques, and like other cases of distant disease, it is indicative of poor prognosis. The invasive urothelial carcinoma is recognized for its ability to present divergent differentiation and morphological variants. The sarcomatoid urothelial carcinoma is a rare cancer that consists of two different components: one composed of epithelial tissue and the other with sarcomatoid features of mesenchymal origin. The authors describe a case of cutaneous metastasis of sarcomatoid urothelial carcinoma in a 63-year-old male patient.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma de Células de Transição/patologia , Carcinossarcoma/patologia , Neoplasias Cutâneas/patologia , Neoplasias da Bexiga Urinária/patologia , Evolução Fatal , Invasividade Neoplásica , Pele/patologia , Urotélio/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA