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1.
An. bras. dermatol ; 94(6): 710-712, Nov.-Dec. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1054894

RESUMO

Abstract Although the association of multiple autoimmune diseases has already been widely described, no reports of the association between vitiligo, primary biliary cirrhosis and Sjogren's syndrome were retrieved in the SciELO and PubMed databases. The authors describe the case of a female patient who was diagnosed with primary biliary cirrhosis and Sjogren's syndrome at age 54. At age 58, she developed vitiligo restricted to the face, associated with significant impairment of self-esteem and quality of life. Antinuclear antibody was negative at the onset of the condition, but became positive after phototherapy initiation. In general, the occurrence of multiple autoimmune diseases in the same patient is known as a mosaic of autoimmunity. However, specific mechanisms appear to interconnect primary biliary cirrhosis and Sjogren's syndrome, such as PDC-E2-mediated generalized epithelitis.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Vitiligo/complicações , Síndrome de Sjogren/complicações , Cirrose Hepática Biliar/complicações , Vitiligo/patologia , Síndrome de Sjogren/patologia , Autoimunidade , Doença Crônica , Cirrose Hepática Biliar/patologia
4.
An. bras. dermatol ; 94(4): 434-441, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1038295

RESUMO

Abstract: Background: In-vitro studies showed that Leucine-rich glioma inactivated 3 (LGI3) is a keratinocyte-derived cytokine that stimulates melanin synthesis and is increased after ultra violet B (UVB) irradiation. So, we postulated that LGI3 may be involved in vitiligo aetiopathogenesis and may participate in narrow band ultra violet B (NB-UVB) induced pigmentation in vitiligo. Objectives: To assess this hypothesis, lesional LGI3 immunohistochemical expression of vitiligo patients before and after NB-UVB phototherapy was studied, and its correlation with repigmentation was evaluated. Methods: Forty vitiligo patients and 20 age, sex, and skin phenotype-matched controls were enrolled. Patients were treated with NB-UVB thrice weekly for 12 weeks. VASI score was evaluated before and after NB-UVB sessions. For vitiligo patients, baseline LGI3 immunohistochemical staining was estimated, and compared to that of controls and to its post-treatment data in those patients. Results: Baseline LGI3 immunohistochemical studied parameters (expression, intensity, percentage and H score) were significantly lower in vitiligo cases than controls (p=0.003, 0.013, 0.001 and 0.001 respectively). After 12 weeks of NB-UVB phototherapy, these LGI3 immunohistochemical parameters were up-regulated and became comparable to that of controls (p >0.05 for all). There was a significant positive correlation between the improvement of both VASI score and LGI3 H score mean values (r=-0.349 , p=0.027). Study limitations: Small number of investigated subjects. Conclusions: Decreased LGI3 protein may play an active role in vitiligo pathogenesis and its up-regulation after NB-UVB phototherapy, may actively participate in NB-UVB photo-induced melanogenesis.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Terapia Ultravioleta/métodos , Vitiligo/patologia , Vitiligo/radioterapia , Proteínas/análise , Citocinas/análise , Valores de Referência , Fatores de Tempo , Índice de Gravidade de Doença , Imuno-Histoquímica , Estudos de Casos e Controles , Queratinócitos/efeitos da radiação , Resultado do Tratamento , Estatísticas não Paramétricas , Melanócitos/efeitos da radiação
7.
An. bras. dermatol ; 93(6): 843-851, Nov.-Dec. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-973635

RESUMO

Abstract: Background: Vitiligo is characterized by a lack of pigmentation in the skin. To date, there are no studies that analyze the changes in gene expression in the skin of vitiligo patients in response to narrow-band ultraviolet B (nb-UVB) phototherapy treatment. Objective: Explore the usefulness of new generation RNA sequencing in the identification of gene expression changes in the skin of vitiligo patients treated with nb-UVB phototherapy. Methods: Four skin biopsies (4mm in diameter) were collected from 45 Mexican vitiligo vulgaris patients, 2 specimens before and 2 after treatment with nb-UVB phototherapy, obtained from pigmented and non-pigmented tissue. RNA extracted from the biopsies was analyzed using the Illumina TruSeq Targeted RNA Expression protocol to study the expression of genes that participate in pathways of skin homeostasis. The 2 groups were compared using Student's t-test and the Mann-Whitney U-test. Results: The expression analysis identified differences in 12 genes included in this study after comparing the samples obtained before and after treatment: 5 genes involved in skin pigmentation, 2 genes involved in apoptosis, 2 genes involved in cell survival, 2 genes involved in oxidative stress responses and 1 gene involved in signal transduction mechanisms (p<0.05). Study limitations: The small size of skin biopsies limits the amount of RNA obtained, the number of genes to be analyzed and the use of conventional techniques such as RT-qPCR. Conclusion: We demonstrated usefulness of new generation RNA sequencing in the identification of gene expression changes, in addition to identifying new targets in the study of vitiligo.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Terapia Ultravioleta , Vitiligo/genética , Vitiligo/radioterapia , Pigmentação da Pele/efeitos da radiação , Análise de Sequência de RNA , Biópsia , Pigmentação da Pele/genética , Resultado do Tratamento , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Transcriptoma
8.
An. bras. dermatol ; 93(4): 539-545, July-Aug. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-949933

RESUMO

Abstract: Background: To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy. Objective: To assess the clinical efficacy of ALA-PDT for treating vitiligo. Methods: ALA with different drug concentrations, drug application durations, irradiation durations and irradiation dosages were adopted to treat skin lesions caused by vitiligo to determine the effective drug concentration, drug application duration, irradiation duration and irradiation dosage for treating three vitiligo volunteers and observe the therapeutic results. Results: The clinical trial suggested that ALA at a drug concentration of 1.5%, drug application duration for 3 hours, irradiation dosage of 80mw/cm2 and irradiation duration for 20 min was effective in treating vitiligo. Under these parameters, ALA-PDT was effective to the three vitiligo volunteers, with mild pain and feeling of burning but no other adverse reaction during treatment. Study limitations: Due to the small sample size in this study for the effectiveness of PDT in treating vitiligo and the potential variations in the efficacy for treating the disease at different areas, further studies shall be conducted for confirmation. Conclusions: ALA with a drug concentration at 1.5%, drug application duration for 3 hours, irradiation dosage of 80 mw/cm2 and irradiation duration for 20 min is effective in treating vitiligo. Therefore, ALA-PDT is safe and effective in treating the disease, with minor adverse events, providing a new method for treating vitiligo in the future.


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adolescente , Adulto , Adulto Jovem , Fotoquimioterapia/métodos , Vitiligo/tratamento farmacológico , Fármacos Fotossensibilizantes/administração & dosagem , Ácidos Levulínicos/administração & dosagem , Projetos Piloto , Resultado do Tratamento
9.
Interface (Botucatu, Online) ; 22(65): 481-491, abr.-jun. 2018. tab
Artigo em Inglês | LILACS | ID: biblio-893494

RESUMO

This study aimed to show the comprehension that patients bearing vitiligo have over their condition, also assessing the association with their health and disease concepts. It is a qualitative research with descriptive and exploratory purposes, carried out from an epidemiological survey throughout the years of 2010-2013, with records from a dermatology outpatient care sector of a seminal hospital located in the city of Campina Grande - Paraíba, Brazil. It was identified that from the 832 existing records, 13 were of vitiligo patients and, from them, eight agreed to be part of this study, answering a semi-structured questionnaire. Data examination was made using the Thematic Content Analysis technique, identifying four categories. Results indicated that the process of being stricken with the disease is directly related to social practices that target the "stained" subject, over whom vitiligo has imprinted its patches.(AU)


O presente estudo teve por objetivo apresentar a compreensão de sujeitos portadores de vitiligo sobre sua afecção, avaliando também a associação com a concepção de saúde-doença. Trata-se de uma pesquisa qualitativa de caráter descritivo e exploratório, realizada a partir de um levantamento epidemiológico do período de 2010-2013, em prontuários do ambulatório de dermatologia de um hospital de referência localizado na cidade de Campina Grande - Paraíba, Brasil. Identificou-se que de 832 prontuários existentes, 13 pacientes possuíam vitiligo e, destes, apenas oito aceitaram participar do estudo, respondendo a um questionário semiestruturado. O tratamento dos dados ocorreu por meio da técnica de análise de conteúdo temática, identificando quatro categorias. Os resultados indicaram que o processo de adoecimento está diretamente ligado às práticas sociais que são direcionadas ao sujeito "manchado", sobre o qual o vitiligo imprimiu suas marcas.(AU)


El objetivo de este estudio fue presentar la comprensión de sujetos portadores de vitíligo sobre su afección, evaluando también la asociación con el concepto de salud-enfermedad. Se trata de una investigación cualitativa de carácter descriptivo y exploratorio, realizada a partir de un levantamiento epidemiológico del período de 2010-2013, en fichas del ambulatorio de dermatología de un hospital de referencia localizado en la ciudad de Campina Grande - estado de Paraíba, Brasil. Se identificó que, de las 832 fichas existentes, 13 pacientes sufrían de vitíligo y de ellos solamente ocho aceptaron participar en el estudio, respondiendo un cuestionario semi-estructurado. El tratamiento de los datos se realizó por medio de la técnica de análisis de contenido temático, identificando cuatro categorías. Los resultados indicaron que el proceso de enfermedad está directamente vinculado a las prácticas sociales que se dirigen al sujeto "manchado", sobre el cual el vitíligo imprimió sus marcas.(AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Dermatologia , Impacto Psicossocial , Vergonha , Vitiligo/psicologia
10.
An. bras. dermatol ; 93(2): 191-196, Mar.-Apr. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-887183

RESUMO

Abstract: Background: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. Objective: To determine the hypothesized role of migration inhibitory factor in vitiligo via estimation of serum migration inhibitory factor levels and migration inhibitory factor mRNA concentrations in patients with vitiligo compared with healthy controls. We also aimed to assess whether there is a relationship between the values of serum migration inhibitory factor and/or migration inhibitory factor mRNA with disease duration, clinical type and severity in vitiligo patients. Methods: Evaluation of migration inhibitory factor serum level and migration inhibitory factor mRNA expression by ELISA and real-time PCR, respectively, were performed for 50 patients with different degrees of vitiligo severity and compared to 15 age- and gender-matched healthy volunteers as controls. Results: There was a highly significant increase in serum migration inhibitory factor and migration inhibitory factor mRNA levels in vitiligo cases when compared to controls (p<0.001). There was a significant positive correlation between both serum migration inhibitory factor and migration inhibitory factor mRNA concentrations in vitiligo patients, and each of them with duration and severity of vitiligo. In addition, patients with generalized vitiligo have significantly elevated serum migration inhibitory factor and mRNA levels than control subjects. Study limitations: Small number of investigated subjects. Conclusions: Migration inhibitory factor may have an active role in the development of vitiligo, and it may also be a useful index of disease severity. Consequently, migration inhibitory factor may be a new treatment target for vitiligo patients.


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Vitiligo/etiologia , Vitiligo/sangue , RNA Mensageiro , Fatores Inibidores da Migração de Macrófagos/análise , Fatores Inibidores da Migração de Macrófagos/fisiologia , Valores de Referência , Fatores de Tempo , Vitiligo/patologia , Índice de Gravidade de Doença , Estudos de Casos e Controles , Expressão Gênica , Estatísticas não Paramétricas , ELISPOT , Reação em Cadeia da Polimerase em Tempo Real
11.
An. bras. dermatol ; 93(2): 302-303, Mar.-Apr. 2018. graf
Artigo em Inglês | LILACS | ID: biblio-1038265

RESUMO

Abstract: IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Transcript levels were determined by a reverse transcription quantitative real-time polymerase chain reaction. Aryl hydrocarbon receptor mRNA expression was drastically increased in patients with vitiligo compared to healthy controls (P = 0.000). Th22 cells may contribute to abnormal immune responses underlying vitiligo.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Vitiligo/genética , Regulação para Cima/genética , Receptores de Hidrocarboneto Arílico/genética , Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética , RNA Mensageiro/genética , Estudos de Casos e Controles , Expressão Gênica , Interleucinas/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa
12.
An. bras. dermatol ; 93(1): 54-58, Jan.-Feb. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-887145

RESUMO

Abstract: Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Egyptian patients with generalized vitiligo. Methods: This study included 122 vitiligo patients and 200 healthy controls that were age, and gender matched. Assessment of GSTM1/T1 gene polymorphisms was done using a multiplex polymerase chain reaction (PCR). Results: Increased odds of generalized vitiligo was observed with the null genotypes of GSTM1 and GSTT1 polymorphisms (P<0.05). Controls with GSTM1 null/GSTT1+ heterozygosis presented with a 2.97 odds protection from having generalized vitiligo (OR=2.97, 95%CI=1.1-7.7) (P=0.02) compared with patients. Study Limitations: Small sample size of patients. Conclusions: This study showed a significant trend towards an association with the combination of the GSTM1/GSTT1 double null polymorphism and generalized vitiligo. Individuals with GSTM1 null/GSTT1+ heterozygosis have a 2.97 odds protection from having generalized vitiligo compared with patients. It was is the first time, to our knowledge, that such an association has been reported.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Polimorfismo Genético/genética , Vitiligo/genética , Predisposição Genética para Doença/genética , Glutationa Transferase/genética , Estudos de Casos e Controles , Egito , Frequência do Gene , Genótipo
13.
Medicina (Bogotá) ; 40(1(120)): 126-127, Ene-Mar, 2018.
Artigo em Espanhol | LILACS | ID: biblio-910112

RESUMO

Introduccion y objetivo: El vitíligo es una hipomelanosis adquirida que se manifiesta clí-nicamente por la aparición progresiva de máculas acrómicas en la piel y cabello de áreas afectadas. La prevalencia mundial es de 0,5% a 2%. El objetivo, es dar a conocer la caracte-rización dermatológica clínica y terapéutica de los pacientes del Hospital Universitario de Santander. Métodos: Estudio observacional, descriptivo de corte transversal retrospectivo. La población estudio fueron pacientes con Vitíligo que ingresaron a un hospital universitario de Colombia entre el período comprendido entre los años 2012-2016 en pacientes mayores de 13 años que ingresen a la institución.


Assuntos
Vitiligo , Fotoquimioterapia
14.
Rev. cientif. cienc. med ; 21(1): 118-121, 2018. ilus
Artigo em Espanhol | LILACS | ID: biblio-959747

RESUMO

El vitíligo es el trastorno despigmentante adquirido más frecuente, con una prevalencia mundial del 0.5-2%. Su mayor incidencia se produce entre los 10 y 30 años. Se asocia a trastornos tiroideos autoinmunes con presencia de anticuerpos antitiroperoxidasa hasta en un 20%. Se presenta el caso de masculino de 15 años de edad, diagnosticado con vitíligo a los 10 años de edad con seguimiento por dermatología, actualmente en tratamiento. El paciente se encuentra en seguimiento médico por obesidad. Se ha descrito asociación positiva entre vitiligo y tiroiditis autoinmune, duplicando el riesgo a los cinco años de diagnóstico concomitante a patología autoinmune previa. Teniendo en cuenta que el vitiligo precede generalmente al inicio de la disfunción tiroidea, el seguimiento periódico de pacientes con vitiligo es de gran importancia.


Vitiligo is the most common acquired depigmentation disorder with a worldwide prevalence from 0.5 to 2%. It is highest incidence occurs between the ages of 10 to 30 years old. Frequently, it is associated with autoimmune thyroid disorders and related to the presence of anti-thyroid peroxidase antibodies in 20% of the times. We present the case of 15 years old male, diagnosed with vitiligo at 10 years old with currently dermatology follow up under treatment. The patient is in medical monitoring due to obesity. It has been described an association between Vitiligo and Thyroiditis, doubling the risk of presence in five years from the concomitant diagnose to a previous autoimmune pathology. Considering that vitiligo usually precedes the onset of thyroid dysfunction, periodic monitoring in patients with this disorder it is of great importance.


Assuntos
Humanos , Masculino , Adolescente , Vitiligo/diagnóstico , Doenças da Glândula Tireoide , Obesidade Abdominal
15.
Rev. cientif. cienc. med ; 21(2): 56-59, 2018. ilus
Artigo em Espanhol | LILACS | ID: biblio-1003800

RESUMO

El síndrome poliglandular autoinmune comprende un grupo de enfermedades autoinmunes de las glándulas endócrinas, y que afecta órganos no endócrinos, puede ser de tipo I, II y III. Paciente masculino de 26 años presenta palpitaciones, debilidad, y disnea de esfuerzos de 2 meses de evolución. Al examen físico, índice de masa corporal 29,6 kg/m², obesidad central, con acromía en cara, axilas y cuello. Los estudios muestran TSH 0,01 uUl/ml,T4 libre 3,67 ng/dl, antitiroperoxidasa 505,70 Ul/ml, insulina en ayunas 32,77 U/l, y a las 2 horas 77 U/l, glicemia en ayunas 101 mg/dl, curva tolerancia oral a la glucosa a las 2 horas de 140 mg/dl. La ecografía tiroidea revela bocio multinodular. Diagnósticos: tiroiditis autoinmune, vitíligo, prediabetes, sobrepeso. Manejo con metimazol 5 mg c/12 h, y metformina 850 mg en la noche. El paciente baja de peso y la glicemia mejora. El diagnóstico definitivo fue Tiroiditis autoinmune y vitíligo compatible con síndrome poliglandular tipo IIIC.


Autoimmune Polyglandular Syndrome comprises a group of autoimmune diseases of the endocrine glands, and affecting non-endocrine organs, there are type I, II and III. Male patient, aged 26 years old has palpitations, weakness, and exertional dyspnea for 2 months. The physical examination found body mass index 29,6 kg/m², central obesity, with acromia on face, armpits and neck. Studies show TSH 0,01 uUl/ml, freeT4 3,67 ng/dl, antithyroperoxidase 505,70 U/ml, fasting insulin 32,77 U/l, after 2 hours 77 U/l, fasting glycemia 101 mg/dl, glucose tolerance at 2 hours 140 mg/dl. Thyroid ultrasound reveals multinodular goiter. Diagnoses: autoimmune thyroiditis, vitiligo, prediabetes, overweight. It prescribed metimazole 5 mg every 12 hours, and metformin 850 mg at night. Patient with weight reduction and glucose improvement. Definitive diagnoses patient with autoimmune thyroiditis and vitiligo, compatible with polyglandular syndrome type IIIC.


Assuntos
Humanos , Masculino , Adulto , Poliendocrinopatias Autoimunes/diagnóstico , Vitiligo , Tireoidite Autoimune , Metimazol/administração & dosagem
16.
An. bras. dermatol ; 92(6): 888-890, Nov.-Dec. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-1038260

RESUMO

Abstract: Surgical management of vitiligo is considered an excellent terapeutic option for recalcitrant cases, provided the disease is stable and there is absence of Koebner phenomenom. Among surgical modalities, Suction Blister Epidermal Graft is a low cost and effective option (65 to 100% repigmentation can be achieved in up to 80% of patients). We describe how it can be optimized by using an alternative suction equipment, by customization of graft format and by application of an anesthetic technique that substantially reduces procedure time.


Assuntos
Humanos , Vitiligo/cirurgia , Transplante de Pele/instrumentação , Transplante de Pele/métodos , Epiderme/transplante , Reprodutibilidade dos Testes , Vesícula
17.
An. bras. dermatol ; 92(6): 811-815, Nov.-Dec. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-887118

RESUMO

Abstract: Background: The onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs. Objective: To compare the clinical profile of pre and postpubertal onset vitiligo. Methods: A cross-sectional observational study was conducted. The Vitiligo European Task Force questionnaire was completed for each patient. Results: A total of 375 patients were included; 199 had postpubertal vitiligo (>12 years), and 176 had prepubertal onset vitiligo (<12years). There were more females in the prepubertal group (49%) than in the postpubertal group (29%), p-value <0.001. The prepubertal group has had more involvement than the postpubertal group (45% vs 30%, p=0.004). Only 8 cases of segmental vitiligo were observed; five were observed in the prepubertal group of patients. Female gender (OR=2.3; 95% CI:1.5, 3.5), presence of halo nevus (OR=2.2; 95% CI:1.1, 4.4) and face involvement (OR=1.9; 95% CI:1.2, 2.9) were positively associated with prepubertal vitiligo. Stress, as an onset factor, was positively associated (OR=0.51; 95% CI:0.3, 0.8) with postpubertal onset vitiligo. Study limitations: A possible selection bias toward more severe vitiligo cases can be a limitation, because the study was conducted in a clinic specialized in vitiligo. Moreover, a likelihood of false recall bias cannot be excluded. Conclusions: Our data present clinical evidence that vitiligo behaves mostly the same way in the prepubertal group as in the postpubertal group. However, female over-representation, more face involvement and more halo nevi were observed in prepubertal vitiligo, while stress was more prevalent as an aggravating factor in postpubertal vitiligo patients.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Vitiligo/fisiopatologia , Puberdade/fisiologia , Estresse Psicológico/fisiopatologia , Índice de Gravidade de Doença , Modelos Logísticos , Fatores Sexuais , Estudos Transversais , Análise Multivariada , Inquéritos e Questionários , Idade de Início , Nevo com Halo/fisiopatologia
18.
Rev. Soc. Bras. Clín. Méd ; 15(4): 235-239, 20170000. tab
Artigo em Português | LILACS | ID: biblio-877079

RESUMO

Objetivo: Analisar a presença de autoanticorpos antitireoidianos (anti-TPO) no soro de pessoas acometidas por vitiligo. Métodos: Estudo do tipo caso-controle retrospectivo realizado em serviço de dermatologia de referência na Amazônia, com amostra constituída por dois grupos: Grupo Vitiligo (n=56), com diagnóstico clínico de vitiligo, e Grupo Controle (n=30), que se declarou sadio, não portador de vitiligo, de outra dermatose e/ou doença autoimune diagnosticada. O registro dos dados foi feito pelo preenchimento de protocolo específico usado em entrevista para ambos os grupos, além de coleta de sangue para dosagem de autoanticorpos anti-TPO para os dois grupos. O teste qui quadrado e a odds ratio (OR) foram utilizados para variáveis qualitativas; para as quantitativas, foi utilizado o teste t de Student, e o nível de significância foi de p≤5%. Resultados: A história pessoal de doença autoimune esteve presente em 7,14% dos portadores versus 0% dos controles. Não houve diferenças estatisticamente relevantes com relação aos antecedentes familiares entre os grupos (OR: 0,5704; p=0,4146). Quanto à positividade para os autoanticorpos anti-TPO (níveis superiores ao ponto de corte), não houve relevância estatística (qui quadrado 2,844; p=0,229). Entretanto, na comparação dos níveis séricos absolutos de autoanticorpos anti-TPO entre os grupos, foram obtidos 129,49±323,88 para o portador da doença e 35,85±13,16 para o controle, com t=2,1602 e p=0,0351. Conclusão: Embora não tenha sido relevante a diferença entre os Grupo Vitiligo e Controle quanto à positividade para o autoanticorpos anti-TPO, ao se considerar a comparação com os valores séricos absolutos do Grupo Vitiligo, estes foram maiores que os apresentados pelos controles, sendo esta diferença estatisticamente relevante.(AU)


Objective: To analyze the presence of antithyroid autoantibodies (anti-TPO) in the serum of people affected by vitiligo. Methods: This is a study of retrospective casecontrol, performed in a reference dermatological center in Amazonia, with a sample consisting of two groups: Vitiligo group (n=56), with clinical diagnosis of vitiligo, and the Control Group (n=30), who was self-declared as healthy, nonvitiligo carrier, with no other dermatosis and/or diagnosed autoimmune disease. The data recording was made with specific protocol completion in an interview for both groups, and blood collection for antithyroid autoantibodies dosage for both groups. Chi-square and odds ratio (OR) tests were used for qualitative variables; for the quantitative ones, t-Student test, and significance level of p≤5%. Results: The personal history of autoimmune disease was present in 7.14% of patients compared to 0% of controls. There were no statistically significant differences in relation to family history between the groups (odds ratio: 0.5704; p=0.4146). As for the positivity for antithyroid autoantibodies (levels above the cutoff point), there was no statistical significance (chi-square=2.844, p=0.229). However, when comparing the absolute serum levels of antithyroid autoantibodies between the groups, 129.49±323.88 was obtained for the carrier of the disease, and 35.85±13:16 to controls, with t=2.1602, and p=0.0351. Conclusion: Although the difference between vitiligo and control groups were not significant regarding positivity for antithyroid autoantibodies, when the comparison with the absolute serum levels of the group with vitiligo was considered, they were higher than those presented by the controls, with this difference being statistically significant.(AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Autoanticorpos/análise , Doenças Autoimunes/complicações , Glândula Tireoide , Vitiligo/fisiopatologia , Estudos de Casos e Controles
20.
An. bras. dermatol ; 92(3): 312-318, May-June 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-886974

RESUMO

Abstract Background: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. Objectives: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. Methods: Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months. Results: Of the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area. Study limitations: Some limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results. CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Vitiligo/cirurgia , Queratinócitos/transplante , Melanócitos/transplante , Transplante Autólogo , Resultado do Tratamento
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