Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 516
Filtrar
Mais filtros










Filtros aplicados

Intervalo de ano de publicação
2.
Rev. Odontol. Araçatuba (Impr.) ; 40(2): 43-47, maio/ago. 2019. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1006564

RESUMO

O objetivo deste estudo é descrever o diagnóstico e conduta clínica no tratamento do Fibroma Traumático (FT). O FT é uma lesão proliferativa de natureza benigna que surge na cavidade bucal devido à traumas de repetição, que desencadeiam reações inflamatórias em tecido conjuntivo, causando uma hiperplasia tecidual, geralmente assintomática, podendo interferir na mastigação e na fala causando desconforto ao paciente. Sua prevalência é alta, geralmente em mucosa jugal, linha oclusal, mucosa labial, língua e gengiva. O tratamento consiste na excisão cirúrgica e a confirmação do diagnóstico é dado através de envio para exame histopatológico. Paciente do gênero masculino, 46 anos de idade, procurou atendimento por apresentar nódulo único, exofítico, unilateral de aproximadamente 3 cm em seu diâmetro, localizado na mucosa jugal do lado direito, com bordas regulares e indolor a palpação, apresentando há cerca de 12 meses. Foi submetido a remoção cirúrgica total da lesão e encaminhamento ao laboratório para análise histopatológica para confirmação diagnóstica, além de proservação do caso em 7, 30 e 60 dias. Desta forma, foi possível concluir que a excisão cirúrgica da lesão promove maior conforto, melhora na fala e mastigação, além de um bom reparo tecidual, devolvendo assim, condições de saúde a mucosa bucal e mínimas chances de recidiva(AU)


The objective of this study is to describe the diagnosis and clinical management in the treatment of Traumatic Fibroma (FT). FT is a proliferative lesion of benign nature that arises in the buccal cavity due to repetitive traumas, which trigger inflammatory reactions in connective tissue, causing a tissue hyperplasia, usually asymptomatic, that can interfere in chewing and speech causing discomfort to the patient. Its prevalence is high, usually in jugal mucosa, occlusal line, labial mucosa, tongue and gingiva. The treatment consists of surgical excision and confirmation of the diagnosis is given by sending for histopathological examination. A 46-year-old male patient sought care for having a single, exophytic, unilateral nodule of approximately 3 cm in diameter, located on the right side of the jugal mucosa, with regular borders and painless palpation, presenting about 12 months. He was submitted to total surgical removal of the lesion and sent to the laboratory for histopathological analysis for diagnostic confirmation, in addition to case proservation at 7, 30 and 60 days. In this way, it was possible to conclude that the surgical excision of the lesion promotes greater comfort, improvement in speech and chewing, besides a good tissue repair, thus returning health conditions to the oral mucosa and minimal chances of relapse(AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Fibroma/cirurgia , Cirurgia Bucal , Fibroma , Fibroma/diagnóstico , Fibroma/terapia , Hiperplasia , Mucosa Bucal/patologia
3.
Braz. j. oral sci ; 18: e191350, jan.-dez. 2019. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1087406

RESUMO

Non-neoplastic proliferative lesions (NNPLs) are alterations that affect oral mucosal tissues. The etiology of these lesions is associated with local irritant processes, principally inflammation, infections and mechanical irritants. NNPLs are classified into four groups: inflammatory fibrous hyperplasia, pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell lesion. Aim: This cross-sectional, quantitative, retrospective, analytical, informative and educational study aimed to evaluate the profiles of patients who were diagnosed with any non-neoplastic proliferative lesion in the Unimontes Stomatology Clinic, Brazil. Methods: From January 2001 to June 2012, 1505 patients were counted who underwent anatomopathological examination, in addition to evaluations for other conditions. Results: Of these 1505 patients, 223 were diagnosed with some type of non-neoplastic proliferative lesion, and statistical analysis showed that 76% were female and 24% male and that 23.3% were between 41 and 50 years of age. Inflammatory fibrous hyperplasia was the most common NNPL (86.5%). Conclusion: Due to the high frequency of these lesions in the dental clinic, this type of survey has significant relevance for informing health professionals about these proliferative processes. This information is necessary, since the dentist is intimately involved in both the etiology, treatment and prevention of these lesions


Assuntos
Humanos , Masculino , Feminino , Granuloma Piogênico , Hiperplasia Gengival , Hiperplasia
4.
Acta cir. bras ; 34(6): e201900607, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1019264

RESUMO

Abstract Purpose Coleus forskohlii Briq., a medicinal plant originally from India, has been indicated against heart disease, expiratory disorders, convulsions, and hepatic changes, among others. In view of the broad pharmacological potential of the plant and the scarce information about its effects, the objective of the present study was to investigate the effect of its use for pretreatment of partially hepatectomized rats. Methods The animals were divided into two experimental groups: Control (CG) receiving physiological saline for 10 days before partial hepatetctomy, and Treated (TG) receiving 40 mg Coleus forskohlii/kg/day for 10 days before partial hepatectomy. The treatments were performed by gastric gavage. After the surgical procedure, treatment was continued according to the following groups: CG 24 h, CG 48 h, TG 24 h, and TG 48 hs, and liver tissue and intracardiac blood samples were obtained for histological and biochemical analysis, respectively. Results No significant differences were observed in mitotic or apoptotic index or in the concentrations of the enzymes AST, ALT and alkaline phosphatase, and no areas of fibrosis were detected. Conclusion Treatment with Coleus forskohlii did not interfere with the course of hepatic hyperplasia.


Assuntos
Animais , Masculino , Ratos , Extratos Vegetais/administração & dosagem , Plectranthus/química , Hepatectomia/métodos , Fígado/patologia , Aspartato Aminotransferases/sangue , Biomarcadores/sangue , Hepatócitos/efeitos dos fármacos , Alanina Transaminase/sangue , Fosfatase Alcalina/sangue , Hiperplasia/tratamento farmacológico , Fígado/cirurgia , Fígado/efeitos dos fármacos
5.
Rev. cuba. endocrinol ; 29(3): 1-14, set.-dic. 2018. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-978391

RESUMO

Introducción: Existen discrepancias en relación con la composición corporal de los pacientes con hiperplasia adrenal congénita (HAC) y la influencia de factores clínicos, hormonales y relacionados con el tratamiento esteroideo. Objetivo: Describir variables clínicas, antropométricas y de composición corporal de pacientes con hiperplasia adrenal congénita y determinar si existe relación entre esta y las variables antes mencionadas. Método: Estudio descriptivo transversal que incluyó a todos los pacientes con hiperplasia adrenal congénita y tratamiento esteroideo sustitutivo, atendidos en endocrinología pediátrica del Instituto Nacional de Endocrinología desde el 2000-2015. Se estudiaron variables clínicas y hormonales. Para las variables cualitativas se calcularon frecuencias absolutas y porcentajes, media y desviación estándar para las variables cuantitativas. Se evaluaron asociaciones utilizando el coeficiente de correlación de Spearman y la prueba chi cuadrado para evaluar la significación estadística de la posible asociación. Resultados: Fueron estudiados 29 pacientes, de las cuales 24 (82,8 por ciento) mujeres. La edad promedio fue 10,9 ± 6,27 años, diagnóstico de 1,9 años ± 2,7 años y edad de inicio del tratamiento 2,03 ± 2,7 años. Predominó el color de la piel blanca: 19 (65,5 por ciento). En la mayoría de los pacientes predominaron altos porcentajes de masa magra y parámetros bioquímicos normales. El uso de mayores dosis de esteroides se correlacionó positivamente con mayor porcentaje de masa grasa, lo mismo sucedió desde el punto de vista clínico (no estadístico), con el mayor tiempo de tratamiento. Los niveles de testosterona plasmáticas no se relacionaron de manera significativa con las características de la composición corporal(AU)


Introduction: There is disagreement with respect to the body composition of patients with congenital adrenal hyperplasia (CAH) and the influence of clinical, hormonal and other factors involved in steroid therapy. Objective: Describe the clinical, anthropometric and body composition variables of patients with congenital adrenal hyperplasia and determine whether there is a relationship between this condition and the aforementioned variables. Method: A descriptive cross-sectional study was conducted of all congenital adrenal hyperplasia patients under replacement steroid therapy cared for at the pediatric endocrinology service of the National Institute of Endocrinology from 2000 to 2015. Clinical and hormonal variables were analyzed. Absolute frequencies and percentages were estimated for qualitative variables, whereas mean and standard deviation were used for quantitative variables. Associations were evaluated with Spearman's rank correlation coefficient, and the chi-square test was applied to evaluate the statistical significance of the possible association. Results: A total 29 patients were studied, of whom 24 (82.8 percent) were women. Mean age was 10.9 ± 6.27 years, diagnosis 1.9 ± 2.7 years and age at the start of therapy 2.03 ± 2.7 years. White skin color prevailed with 19 (65.5 percent). In most patients there was a predominance of high lean mass percentages and normal biochemical parameters. A positive correlation was found between the use of higher steroid doses and a higher lean mass percentage. The same occurred from a clinical (non-statistical) point of view with a longer therapy time. Plasma testosterone levels did not show a significant relationship to body composition characteristics(AU)


Assuntos
Humanos , Feminino , Criança , Testosterona/uso terapêutico , Composição Corporal , Análise Estatística , Hiperplasia/terapia , Epidemiologia Descritiva , Estudos Transversais
6.
Pesqui. vet. bras ; 38(8): 1638-1648, Aug. 2018. tab, graf
Artigo em Português | LILACS, VETINDEX | ID: biblio-976481

RESUMO

Apesar da prevalência da peritonite infecciosa felina (PIF) ser alta em praticamente o mundo todo, estudos anatomopatológicos recentes acerca dessa doença são escassos. Não obstante, as características microscópicas da medula óssea de gatos com PIF estão ausentes da literatura consultada. O objetivo deste artigo é descrever alterações medulares ósseas vistas em casos espontâneos de PIF. As medulas ósseas colhidas sistematicamente da região diafisária dos fêmures de 16 gatos necropsiados no Laboratório de Patologia Veterinária (LPV) da Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, entre janeiro de 2000 e junho de 2017, e que tiveram diagnóstico definitivo de PIF, foram avaliadas fenotípica (histopatologia - hematoxilina e eosina e histoquímica - reação de Perls) e imunofenotipicamente (utilizando marcadores mieloides (anti-MAC387) e de linfócitos (anti-CD79αcy e anti-CD3). Os resultados permitem afirmar que, independentemente da apresentação clinicopatológica da doença ocorrem as seguintes alterações: 1) hiperplasia mieloide; 2) hipoplasia eritroide, 3) displasia megacariocítica (dismegacariocitopoiese) e 4) plasmocitose medular. Exclusivamente nos casos de PIF seca há hemossiderose medular óssea e hepática. Essas alterações permitem estabelecer que gatos com PIF desenvolvem mielodisplasia, uma lesão mieloproliferativa muito semelhante àquela relatada em humanos infectados pelo HIV. Sugere-se que a partir dos achados aqui descritos, a mielodisplasia seja considerada a principal responsável pelas alterações hematológicas observadas na PIF, especialmente pela anemia e trombocitopenia arregenerativas frequentemente desenvolvidas pelos pacientes com essa doença.(AU)


Although the prevalence of feline infectious peritonitis (FIP) is high worldwide, recent anatomopathological studies about this disease are scarce. Information on the microscopic characteristics of the bone marrow in FIP-affected cats are absent in the available literature. Based on this, the purpose of this article is to describe bone marrow lesions seen in spontaneous cases of FIP. The bone marrow collected systematically from the femoral diaphysis of 16 cats necropsied in the Laboratory of Veterinary Pathology (LPV) of the Federal University (UFSM) of Southern Brazil, between January 2000 and June 2017, with a definitive diagnosis of FIP, were evaluated phenotypically (histopathology - hematoxylin and eosin and histochemistry - Perls stain) and immunophenotypically (immunohistochemistry using myeloid - Anti-MAC387, and lymphocytic - Anti-CD79 αcy and Anti-CD3 markers). Regardless the following was observed the clinicopathological form of the disease ("dry" - noneffusive or "wet" - effusive): 1) myeloid hyperplasia; 2) erythroid hipoplasia; 3) megakaryocytic dysplasia (dismegakaryocytopoiesis); and 4) medullary plasmacytosis. Exclusively in cases of "dry FIP" was bone marrow and hepatic hemosiderosis. These lesions allowed establishing that cats with FIP develop myelodysplasia, a myeloproliferative lesion very similar to that reported in HIV-infected humans. It is suggested that, based on the findings described here, myelodysplasia is considered to be the main cause of hematological abnormalities observed in FIP, especially for non-regenerative anemia and thrombocytopenia, frequently developed by patients.(AU)


Assuntos
Animais , Gatos , Gatos/anormalidades , Peritonite Infecciosa Felina/diagnóstico , Hiperplasia/veterinária , Defeitos do Tubo Neural/diagnóstico
7.
Pesqui. vet. bras ; 38(6): 1030-1037, jun. 2018. graf
Artigo em Português | LILACS, VETINDEX | ID: biblio-955448

RESUMO

Bócio é o aumento não inflamatório e não neoplásico da glândula tireoide em animais adultos e recém-nascidos. Uma das principais causas envolvidas é a deficiência nutricional de iodo. Relata-se neste trabalho, a ocorrência de três surtos de bócio em bovinos. Na primeira propriedade (Propriedade A), 60 bezerros foram afetados, sendo que 20 morreram logo após o nascimento, 30 recuperaram-se e 10 permaneceram doentes e tiveram remissão dos sinais apenas após tratamento parenteral com iodo. Na segunda propriedade (Propriedade B) uma vaca e seu feto foram acometidos e na terceira (Propriedade C) dois bezerros foram afetados. Os principais sinais clínicos observados nos bezerros foram aumento de volume bilateral na região cervical ventral, emagrecimento, dificuldade respiratória, hipotricose e desenvolvimento corpóreo retardado. Na propriedade A foi relatada ainda a ocorrência de abortamentos. Macroscopicamente, os bezerros e o feto apresentavam tireoide aumentada, vermelho-escura, com vascularização evidente e edema subcutâneo cervical. No surto dois também foi observado, à necropsia, aumento de volume da glândula tireoide da vaca. Microscopicamente, a tiroide dos bezerros e do feto apresentava folículos tireoidianos hiperplásicos, heterogêneos, destituídos de coloide e com interstício acentuadamente vascularizado. A tireoide da vaca era semelhante à dos bezerros, no entanto, possuía quantidade maior de coloide. Em todos os casos a suplementação mineral era realizada por meio da mistura de sal mineral com sal branco. Na Propriedade A o sal branco era não iodado e misturado em partes iguais com o sal mineral. Na Propriedade B o sal também era misturado a um sal branco não iodado na proporção e 1:2, respectivamente. Na Propriedade C o sal mineral e o sal branco não iodado eram ofertados em cochos separados no campo e, segundo relato do proprietário, os animais priorizavam o consumo do sal branco. Em todas as propriedades acompanhadas foi recomendada a interrupção da adição de sal branco na mistura mineral e a administração de iodo aos bezerros acometidos. Após essas medidas não foram observados novos casos nas propriedades. Apesar de ser uma enfermidade bem conhecida, ainda são poucos os relatados de casos de bócios em bovinos no Brasil. Além disso, pouco se sabe sobre as reais deficiências minerais de cada região, e que simples orientações de manejo nutricional ainda são necessárias.(AU)


Goiter is a non-inflammatory and non-neoplastic enlargement of the thyroid gland in adults and neonates. One of the main causes involved is the nutritional deficiency of iodine. In this study three outbreaks of goiter in cattle are reported. In the first outbreak (Farm A) 60 calves were affected, of which 20 died soon after birth, 30 recovered and 10 remained sick. In the second outbreak (Farm B) a cow and its fetus were affected and in the third outbreak (Farm C) two calves were affected. The main clinical signs observed were bilaterally enlarged thyroid glands, weight loss, respiratory distress, hypotrichosis and myxedema. Additionally in the Farm A abortions were reported. Macroscopically the thyroid of the calves and fetus was enlarged, dark red with evident vascularization and cervical subcutaneous edema. In the Farm B the cow showed enlarged thyroid gland as well. Microscopically the calves and the fetus had hyperplastic and heterogeneous thyroid follicles with absence of colloid and vascularized interstitium. The thyroid of the cow was also hyperplastic, but had higher amount of colloid. In all outbreaks the mineral supplementation was performed by mixing non-iodized white salt with the mineral mixture. On the property A the white salt was non-iodized and mixed in equal parts with the mineral salt. At property B the salt was also mixed to a non-iodized white salt in ratio and 1:2, respectively. In the property C, mineral salt and non-iodized white salt were offered in separate troughs in the field, and according to the owner's report the animals prioritized the consumption of white salt. In all the monitored properties it was recommended to stop the addition of white salt in the mineral mixture and the administration of iodine to the affected calves. After these measurements no new cases were observed in the properties. Despite being a well-known disease, there are still few reported cases of goiter in cattle in Brazil. Moreover, little is known about the actual mineral deficiencies of each region, and that simple nutritional management guidelines are still needed.(AU)


Assuntos
Animais , Bovinos , Bovinos/anormalidades , Bócio/diagnóstico , Hiperplasia/diagnóstico , Iodo/deficiência
8.
Rev. bras. cir. plást ; 32(4): 579-582, out.-dez. 2017. ilus, tab
Artigo em Inglês | LILACS | ID: biblio-878784

RESUMO

Introdução: Ginecomastia é a hipertrofia e hiperplasia benigna da mama masculina. Representa a condição benigna mais frequente da mama masculina. O objetivo é avaliar os resultados estéticos, e satisfação dos pacientes submetidos a uma nova abordagem para o tratamento da ginecomastia, com incisão periareolar em zigue-zague. Métodos: Apresentamos uma casuística de 13 casos de ginecomastia tratados com a técnica periareolar em zigue-zague. Resultados: Todos os pacientes ficaram satisfeitos com a cicatriz camuflada na transição, naturalmente irregular, da pele periareolar com o complexo aréolo mamilar. Não houve complicações na série descrita. Conclusão: A abordagem descrita é uma excelente alternativa para o tratamento das ginecomatias. Proporciona um resultado estético satisfatório, é de fácil execução e tem a vantagem de não deixar estigmas na mama masculina operada.


Introduction: Gynecomastia is a benign hypertrophy and hyperplasia of the male mammary gland, and is considered the most frequent benign condition of the male breast. The objective is to evaluate aesthetic results and satisfaction of patients undergoing a new approach using a periareolar zigzag incision for the treatment of gynecomastia. Methods: We present 13 cases of male gynecomastia treated with a periareolar zigzag incision technique. Results: All patients were satisfied with the scar hidden in the transitional, naturally irregular periareolar skin of the nipple-areolar complex. No complications were observed in this patient series. Conclusion: This approach is an excellent, easy-to-perform surgical alternative for the treatment of gynecomastia, providing a satisfactory cosmetic result without the presence of a stigmatizing scar.


Assuntos
Humanos , Masculino , História do Século XXI , Cicatriz , Procedimentos Cirúrgicos Reconstrutivos , Difusão de Inovações , Ginecomastia , Hiperplasia , Hipertrofia , Cicatriz/cirurgia , Cicatriz/terapia , Procedimentos Cirúrgicos Reconstrutivos/métodos , Procedimentos Cirúrgicos Reconstrutivos/normas , Ginecomastia/cirurgia , Hiperplasia/cirurgia , Hipertrofia/cirurgia
9.
Int. j. morphol ; 35(2): 479-487, June 2017. ilus
Artigo em Inglês | LILACS | ID: biblio-893008

RESUMO

When a vein segment is grafted into arterial circulation, biomechanical forces stimulate modification of its structure. This morphological adaptive response is progressive during a medium or long term and occludes the vessel lumen, leading to a graft failure. The objective of this study was to characterize the early morphological response of the vascular wall in a terminal-terminal vascular vein graft model in Wistar rats. A segment of the femoral vein was placed in the femoral circulation. An end to end microsurgical graft anastomosis technique was implemented and standardized in twenty rats. The samples were processed with histological technique to analyze the overall structure with hematoxylin and eosin, the composition of the vessel wall with Masson trichrome technique, the proliferating and smooth muscle cells were detected with immunohistochemistry (anti-PCNA, anti-actin and anti CD68) and the induction of apoptosis with TUNEL technique. The times periods studied were 1, 3 and 5 days postoperative. There is progressive increase of cell proliferation and intensity of the density detected by PCNA with its peak at postoperative day 3. Apoptosis was not evident in any of the postoperative days. Smooth muscle had no significant change in any of the time periods studied. Macrophage and leukocyte migration was evident since the first postoperative day with infiltration into the media by the 5th day. This study characterizes the morphological aspects in the early arterialization of the vascular wall in a vein graft process. These results contribute to a better understanding of the morphopathological mechanism involved in vein graft failure.


Cuando un segmento venoso es injertado dentro de la circulación arterial, se generan fuerzas biomecánicas que estimulan modificaciones en su estructura. Esta respuesta morfológica adaptativa es progresiva a mediano y largo plazo y termina por ocluir la luz del vaso, conduciendo a la falla del injerto. El objetivo de este estudio fue caracterizar la respuesta morfológica adaptativa temprana de la pared vascular en un modelo de injerto vascular venoso termino-terminal en ratas Wistar. Un segmento de la vena femoral se coloco en la circulación arterial femoral. Una anastomosis del injerto microquirúrgica termino-terminal fue implementada y estandarizada en veinte ratas. Las muestras se procesaron con la técnica histológica para analizar su estructura general con la tinción de hematoxilina y eosina, la composición de la pared vascular con la técnica de tricromico de Masson , la proliferación y las células de musculo liso fueron detectadas mediante técnicas inmunohistoquimicas (anti PCNA, anti-actina y anti CD68) y la inducción de la apoptosis mediante la técnica de TUNEL. Los tiempos de estudio fueron al día 1, 3 y 5 postoperatorios. Hay un incremento progresivo en la proliferación celular y la intensidad de la densidad detectado mediante PCNA con un pico en el día 3 postoperatorio. La apoptosis no fue evidente en ninguno de los días postoperatorios. Las células de musculo liso no tuvieron un cambio significativo en ninguno de tiempos de estudio. La migración de macrófagos y leucocitos fue evidente desde el primer día postoperatorio con infiltración a la túnica media al 5to día. Conclusiones. Este estudio caracteriza los aspectos morfológicos en el proceso de arterialización temprana de la pared vascular en un injerto venoso. Estos resultados contribuyen al mejor entendimiento de los mecanismos morfopatológicos envueltos en la falla del injerto venoso.


Assuntos
Animais , Ratos , Veia Femoral , Microcirurgia/métodos , Modelos Anatômicos , Enxerto Vascular , Veias/cirurgia , Adaptação Fisiológica , Hiperplasia , Imuno-Histoquímica , Ratos Wistar
10.
Rev. bras. cir. plást ; 32(2): 295-298, 2017. ilus
Artigo em Inglês, Português | LILACS | ID: biblio-847450

RESUMO

A Hiperplasia Estromal Pseudoangiomatosa (PASH) é uma doença benigna caracterizada pela proliferação excessiva de fibroblastos e miofibroblastos, podendo levar a um crescimento mamário importante. A apresentação é rara, em especial ocasionando necessidade de mastectomia em pacientes jovens. O estudo apresentou o relato de caso raro de uma paciente de 11 anos de idade, com hipertrofia mamária de rápida progressão, com necessidade de mastectomia e posteriormente mamoplastia de aumento para completa reinserção social.


Pseudoangiomatous stromal hyperplasia is a benign disease characterized by excessive proliferation of fibroblasts and myofibroblasts, which can lead to significant breast growth. The presentation is rare, especially among young women and cases requiring mastectomy. This report describes a rare case of an 11-year-old female patient with rapidly progressing mammary hypertrophy, who needed mastectomy and then mammoplasty for complete social integration.


Assuntos
Humanos , Feminino , Criança , História do Século XXI , Mama , Criança , Mamoplastia , Miofibroblastos , Fibroblastos , Hiperplasia , Mastectomia , Mama/anormalidades , Mama/cirurgia , Mama/crescimento & desenvolvimento , Mamoplastia/efeitos adversos , Mamoplastia/métodos , Miofibroblastos/citologia , Fibroblastos/citologia , Hiperplasia/cirurgia , Hiperplasia/patologia , Mastectomia/efeitos adversos , Mastectomia/métodos
11.
Clinics ; 71(10): 600-605, Oct. 2016. tab
Artigo em Inglês | LILACS | ID: lil-796871

RESUMO

OBJECTIVES: To evaluate the safety and long-term efficacy of computed tomography-guided percutaneous ethanol ablation for benign primary and secondary hyperfunctioning adrenal disorders. METHOD: We retrospectively evaluated the long-term results of nine patients treated with computed tomography-guided percutaneous ethanol ablation: eight subjects who presented with primary adrenal disorders, such as pheochromocytoma, primary macronodular adrenal hyperplasia and aldosterone-producing adenoma, and one subject with Cushing disease refractory to conventional treatment. Eleven sessions were performed for the nine patients. The patient data were reviewed for the clinical outcome and procedure-related complications over ten years. RESULTS: Patients with aldosterone-producing adenoma had clinical improvement: symptoms recurred in one case 96 months after ethanol ablation, and the other patient was still in remission 110 months later. All patients with pheochromocytoma had clinical improvement but were eventually submitted to surgery for complete remission. No significant clinical improvement was seen in patients with hypercortisolism due to primary macronodular adrenal hyperplasia or Cushing disease. Major complications were seen in five of the eleven procedures and included cardiovascular instability and myocardial infarction. Minor complications attributed to sedation were seen in two patients. CONCLUSION: Computed tomography-guided ethanol ablation does not appear to be suitable for the long-term treatment of hyperfunctioning adrenal disorders and is not without risks.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Técnicas de Ablação/métodos , Hiperfunção Adrenocortical/cirurgia , Etanol/uso terapêutico , Tomografia Computadorizada por Raios X/métodos , Neoplasias do Córtex Suprarrenal/cirurgia , Neoplasias das Glândulas Suprarrenais/cirurgia , Adrenalectomia/métodos , Adenoma Adrenocortical/cirurgia , Aldosterona/biossíntese , Síndrome de Cushing/cirurgia , Hiperplasia/cirurgia , Feocromocitoma/cirurgia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Resultado do Tratamento
12.
J. appl. oral sci ; 24(4): 359-365, July-Aug. 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-792590

RESUMO

ABSTRACT Objective This study aimed to evaluate apoptosis by assessing cleaved caspase-3 immunoexpression in hyperplastic, potentially malignant disorder (PMD), and malignant tumors in intraoral and lower lip sites. Material and Methods A retrospective study using paraffin blocks with tissues from patients with inflammatory fibrous hyperplasia (IFH), actinic cheilitis, oral leukoplakia, lower lip and intraoral squamous cell carcinoma (SCC) was performed. The tissues were evaluated by immunohistochemical analysis with anti-cleaved caspase-3 antibody. Apoptotic area index was then correlated with lesion type. Results From 120 lesions assessed, 55 (46%) were cleaved caspase-3-positive. The SCC samples (n=40) had the highest apoptotic area indices (n=35; 87.5%). Significant differences were detected between SCCs and PMDs (p=0.0003), as well as SCCs and IFHs (p=0.001), regarding caspase-3 immunopositivity. Carcinomas of the lower lip had lower apoptotic area indices than intraoral cancer (p=0.0015). Conclusions Cleaved caspase-3 immunoexpression showed differences in oral SCCs and PMDs and demonstrated a distinct role of apoptosis in carcinogenesis of intraoral and lower lip cancer. In future, the expression of cleaved caspase-3 with other target molecules in oral cancer may be helpful in delineating the prognosis and treatment of these tumors.


Assuntos
Humanos , Apoptose , Carcinoma de Células Escamosas/patologia , Caspase 3/análise , Leucoplasia Oral/patologia , Neoplasias Labiais/patologia , Neoplasias Bucais/patologia , Carcinogênese/patologia , Carcinoma de Células Escamosas/enzimologia , Queilite/enzimologia , Queilite/patologia , Hiperplasia/enzimologia , Hiperplasia/patologia , Imuno-Histoquímica , Leucoplasia Oral/enzimologia , Neoplasias Labiais/enzimologia , Neoplasias Bucais/enzimologia , Inclusão em Parafina , Prognóstico , Estudos Retrospectivos , Estatísticas não Paramétricas
13.
Rev. Clín. Ortod. Dent. Press ; 15(3): 61-78, jun.-jul. 2016. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-856056

RESUMO

Introdução: a hiperplasia do côndilo (HC) mandibular tem sido descrita como o crescimento excessivo de um dos côndilos sobre o contralateral, causando um crescimento desequilibrado, que resulta em assimetria facial. A classificação e o diagnóstico da HC, a atividade de crescimento dos côndilos, e as formas de tratamento foram abordados no presente estudo. Material e Métodos: foram descritas as formas de tratamento de três pacientes apresentando HC. As soluções cirúrgicas são representadas por condilectomia, cirurgia ortognática, e uma combinação de ambos. Resultados: após a realização do procedimento cirúrgico específico indicado para cada caso, houve melhora significativa na simetria facial e na função mastigatória. Conclusões: o diagnóstico da HC se baseia em achados clínicos e radiológicos, e esses avaliam as consequências do crescimento desproporcional. A cintilografia óssea funciona como um indicador da rapidez da progressão dessa condição, sendo essencial no planejamento cirúrgico do tratamento


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Assimetria Facial/terapia , Côndilo Mandibular/cirurgia , Hiperplasia/diagnóstico , Hiperplasia/terapia , Hiperplasia/complicações , Cirurgia Ortognática
14.
Rev. gastroenterol. Perú ; 36(2): 123-128, abr.-jun.2016. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-790244

RESUMO

Existe un grupo de enteropatía conocidas como AVSN que pueden simular enfermedad celíaca. Objetivo: El objetivo de este estudio es describir los hallazgos histológicos y de inmunohistoquímica en pacientes con enfermedad celíaca y AVSN. Material y métodos: 15 biopsias de pacientes con enfermedad celíaca y 19 biopsias con AVSN fueron reexaminados. Se estudió características histológicas tales como atrofia severa, hiperplasia de criptas, número de células plasmáticas, número de eosinófilos y presencia de neutrófilos. Asimismo, a través de inmunohistoquímica se estudió la presencia de linfocitos CD4, CD8, CD3, CD56. Resultados: Se encontró diferencia significativa en la mayor presencia de hiperplasia de criptas (p=0,0348) y mayor número de células plasmáticas (p=0,0348) en las biopsias de enfermedad celíaca que en las catalogadas como AVSN. El número de linfocitos CD8, CD4, CD56 y su distribución fue similar en ambos grupos. El porcentaje de linfocitos intraepiteliales CD3 positivos (p=0,0144) fue mayor en pacientes con AVSN. Conclusión: Los hallazgos histológicos e inmunohistoquímicos muestran más similitudes que diferencias. La diferencia hallada en nuestro estudio sugiere mayor respuesta inmune humoral en pacientes con enfermedad celiaca que en AVSN...


There is a group of enteropathies recently known as seronegative villous atrophy (SNVA), which can simulate celiac disease. Objective: The aim of this study was to describe histological and immunohistochemical differences between a group of Celiac disease and SNVA patients. Material and methods: Microscopy reexamination and Immunohistochemistry study were performed for a group of 15 celiac patients and 19 SNVA patients. Histological features as severe atrophy, crypt hyperplasia, plasma cells number, eosinophils number, neutrophils presence were studied; CD4, CD8, CD3, and CD56 markers were studied through immunohistochemistry. Results: There was a significant difference between the frequency of observation of crypt hyperplasia (p=0.0348) and plasma cells (p=0.0348) in celiac disease patients than SNVA patients. In celiac disease was bigger. The number and distribution of CD 8, CD4 and CD56 lymphocytes was similar in both groups. The percentage of CD3 positive intraepithelial lymphocytes (p=0.0144) was higher in SNVA. Conclusion: Histological and immunohistochemical evaluation shows more similarities than differences. The differences found in this study suggest more humoral immune response in celiac disease than in SNVA...


Assuntos
Humanos , Doença Celíaca , Hiperplasia , Estudos Transversais , Estudos Retrospectivos
15.
Rev. Col. Bras. Cir ; 43(1): 28-34, Jan.-Feb. 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-779027

RESUMO

Objective: to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves. Methods : we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05. Results : there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty. Conclusion : there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.


Objetivo: determinar a diferença da média de hiperplasia miointimal pós-angioplastia na artéria ilíaca de coelhos tratados e não tratados com extrato das folhas de Moringa oleifera. Métodos: ensaio aleatório em animais de laboratório por cinco semanas de seguimento, desenvolvido no Biotério do Laboratório de Tecnologia Farmacêutica da Universidade Federal da Paraíba. Foram utilizadas coelhas da raça Nova Zelândia, submetidas à dieta hipercolesterolêmica e angioplastia da artéria ilíaca externa, randomizadas em dois grupos: Grupo M200 (n=10), coelhas tratadas com 200mg/kg/dia de extrato de folhas de Moringa oleifera, por via oral; Grupo SF (n=10), coelhas tratadas com soro fisiológico 0,9%, por via oral. Após cinco semanas, os animais foram eutanaziados e as artérias ilíacas preparadas para histologia. Os cortes histológicos foram analisados por morfometria digital. A análise estatística foi realizada com o teste t de Student. O nível de significância foi 0,05. Resultados: comparando as artérias ilíacas submetidas à angioplastia do grupo M200 com as do grupo SF, não houve diferença significativa da hiperplasia miointimal Conclusão: não houve diferença da hiperplasia miointimal nos grupos tratados com soro fisiológico e Moringa oleifera após angioplastia.


Assuntos
Animais , Feminino , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Extratos Vegetais/uso terapêutico , Túnica Íntima/patologia , Angioplastia/efeitos adversos , Moringa oleifera , Artéria Ilíaca/patologia , Fitoterapia , Coelhos , Distribuição Aleatória , Hiperplasia/etiologia , Hiperplasia/prevenção & controle
16.
Repert. med. cir ; 25(2): 79-88, 2016. Cuadros,, tablas
Artigo em Espanhol | LILACS, COLNAL | ID: lil-795749

RESUMO

La hiperplasia adrenal congénita es un conjunto de anomalías con herencia autosómica recesiva por el déficit de una de las cinco enzimas necesarias para la síntesis de cortisol en la corteza adrenal. La causa más frecuente es la deficiencia de 21 hidroxilasa, que explica más del 95% de los casos. La presentación es heterogénea y depende de cuán afectada está la función enzimática y el sexo del paciente. Se clasifica en una variante no clásica y clásica, esta se subclasifica en una forma con pérdidas salinas y virilizante simple. El tratamiento se fundamenta en el uso de glucocorticoides y mineralocorticoides, con un seguimiento estricto para minimizar las reacciones adversas.Objetivo: Revisión descriptiva sobre el estado del arte de la hiperplasia adrenal congénita.Materiales y métodosRevisión no sistemática de la literatura mediante los buscadores Medline, PubMed, LILACS y la herramienta Clinical Key de publicaciones en los últimos diez años. Se usaron las palabas: hiperplasia adrenal congénita, déficit de 21 hidroxilasa y ambigüedad sexual.Discusión y conclusión: Como es una enfermedad de gran variabilidad en la presentación clínica y las características paraclínicas, es necesario que los profesionales de la salud tengan amplio conocimiento en cuanto a su forma de presentación, diagnóstico y manejo en situaciones especiales (crisis adrenal, dosis de estrés, embarazo), además de realizar seguimiento regular e intervenciones tempranas con el fin de mermar las consecuencias deletéreas, derivadas del tratamiento con corticoides en forma crónica...


Congenital adrenal hyperplasia is a group of autosomal recessive anomalies caused by a deficiency of one of the five enzymes required for the synthesis of cortisol in the adrenal cortex. The most common cause is 21-hydroxylase deficiency, which accounts for over 95% of cases. The presentation is heterogeneous and depends on how much the enzymatic function is affected, and sex of the patient. It is classified as a non-classical and classical variant, which is sub-classified into simple virilising and salt loss. The treatment is based on the use of mineralocorticoids and glucocorticoids, with close monitoring to minimise adverse reactions.Objective: To present a descriptive review of the state of art of congenital adrenal hyperplasia.Materials and methods: A non-systematic review of publications in the literature over the past ten years using the Medline, PubMed, LILACS and Clinical Key. The search words used were: congenital adrenal hyperplasia, 21-hydroxylase deficiency, and sexual ambiguity.Discussion and conclusion: Congenital adrenal hyperplasia is a disease of great variability in clinical presentation and para-clinical characteristics. Health professionals should have extensive knowledge in its presentation, diagnosis, and management in special situations (adrenal crisis, stress dose, pregnancy). It also requires regular monitoring and early interventions in order to reduce the deleterious consequences arising from continuous treatment with corticosteroids...


Assuntos
Humanos , Genitália/anormalidades , Hiperplasia , Triagem Neonatal , Terapêutica
17.
Neotrop. ichthyol ; 14(2): e150149, 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-785077

RESUMO

This study aimed to evaluate muscle organization in tambaqui in order to describe the muscle growth process. We analyzed the morphometric pattern of fibers from white muscle of young-adults (300 days) by smaller diameter. The organization of white muscle exhibited a typical morphological pattern found in other fish species. Heavier animals showed higher frequency of larger diameter fibers (>50 m ) and smaller animals had higher frequency of smaller diameter fibers ( 20 m ) (P =0.005). However, both animals showed the same frequency of intermediate diameter fibers (20-50 m ). Body weight showed a positive correlation with muscle diameter fiber (r=0.45), being 20-50 m the diameters that contributed the most to animal weight (P 0.0001). A weak correlation between fiber diameter and animal sex was observed (r=0.2). Females showed higher frequency of large fiber diameters (>50 m ) than males. However, there was no difference between body weight and sex (P =0.8). Our results suggest that muscle growth is by hypertrophy and hyperplasia due to a mosaic appearance from different diameters fibers, which is characteristic of large size fish species.


O objetivo deste trabalho foi avaliar a organização muscular em tambaqui, a fim de descrever o processo de crescimento muscular. Foi analisado o padrão morfométrico das fibras do músculo branco de animais com 300 dias de idade usando o método de diâmetro menor. O músculo branco apresentou uma organização morfológica padrão encontrado em peixes. Animais de maior peso apresentaram maior frequência de fibras de maior diâmetro (> 50 m ) e os animais de menor peso apresentaram maior frequência de fibras de menor diâmetro ( 20 m ) (P = 0,005). Entretanto, ambos os animais, com maior e menor peso, apresentaram frequências semelhantes de fibras de diâmetro intermediário (20-50 m ). O parâmetro peso corporal mostrou correlação positiva com o diâmetro da fibra muscular (r = 0,45), sendo as fibras de diâmetro intermediários (20-50 m ) que mais contribuíram para o peso do animal (P 0,0001). Fêmeas apresentaram maior frequência de fibras de maior diâmetro (>50 m ) que machos. Observou-se uma fraca correlação entre o diâmetro da fibra e o sexo dos animais (r = 0,2). Apesar de fraca, a correlação estimada é corroborada pela fibras de grandes diâmetros (> 50 m ) serem mais frequente nas fêmeas que nos machos. No entanto, não houve diferença entre o peso corporal dos animais aos 300 dias de idade e sexo (P = 0,8). Os resultados encontrados sugerem que o crescimento muscular ocorre por hipertrofia e hiperplasia, caracterizado pela aparência em mosaico de fibras de diferentes diâmetros, característico de peixes de grande tamanho.


Assuntos
Animais , Masculino , Feminino , Caraciformes/anatomia & histologia , Caraciformes/crescimento & desenvolvimento , Caraciformes/fisiologia , Desenvolvimento Muscular/fisiologia , Hiperplasia/veterinária , Hipertrofia/veterinária
18.
Rev. obstet. ginecol. Venezuela ; 75(4): 280-283, dic. 2015.
Artigo em Espanhol | LILACS | ID: lil-783110

RESUMO

Presentamos el caso de una paciente de 35 años de edad, VII gestas, VI molas I aborto, portadora de la mutación en la proteína NLRP7, evaluada en el servicio de patología del primer trimestre del embarazo de la Maternidad “Concepción Palacios” entre los años 1998- 2010. Ambos padres tenían cariotipos normales y se detectó un antecedente familiar de embarazo molar. Este caso forma parte de un raro subconjunto de molas cuyo origen es biparental, generalmente recurrente y a menudo familiar y se asocia a imposibilidad de obtener un embarazo exitoso.


We report the case of a 35 years old patient, with 7 pregnancies, 6 molas, 1 abortion, carrier of a mutation in the protein NLRP7, evaluated in the pathology service of the Maternidad “Concepcion Palacios” between 1998-2010. Both parents had normal karyotypes and a family history of molar pregnancy was detected. This case is part of a rare subset of molas with biparental origin, usually recurrent and often family and associated with failure to obtain a successful pregnancy.


Assuntos
Humanos , Masculino , Feminino , Gravidez , Doença Trofoblástica Gestacional , Mola Hidatiforme , Hiperplasia , Incidência , Complicações na Gravidez , Genes , Fatores de Risco
19.
Braz. j. med. biol. res ; 48(11): 1039-1047, Nov. 2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-762910

RESUMO

We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia, squamous metaplasia, moderate dysplasia, adenomatous hyperplasia, severe dysplasia, squamous cell carcinoma and adenocarcinoma. Matched lung parenchyma tissue samples included 25 squamous cell carcinomas and 31 adenocarcinomas. Immunohistochemistry was performed to analyze for the distribution of hyaluronidase (Hyal)-1 and −3, and hyaluronan synthases (HAS)-1, −2, and −3. Hyal-1 showed significantly higher expression in basal cell hyperplasia than in moderate dysplasia (P=0.01), atypical adenomatous hyperplasia (P=0.0001), or severe dysplasia (P=0.03). Lower expression of Hyal-3 was found in atypical adenomatous hyperplasia than in basal cell hyperplasia (P=0.01) or moderate dysplasia (P=0.02). HAS-2 was significantly higher in severe dysplasia (P=0.002) and in squamous metaplasia (P=0.04) compared with basal cell hyperplasia. HAS-3 was significantly expressed in basal cell hyperplasia compared with atypical adenomatous hyperplasia (P=0.05) and severe dysplasia (P=0.02). Lower expression of HAS-3 was found in severe dysplasia compared with squamous metaplasia (P=0.01) and moderate dysplasia (P=0.01). Epithelial Hyal-1 and −3 and HAS-1, −2, and −3 expressions were significantly higher in pre-neoplastic lesions than in neoplastic lesions. Comparative Cox multivariate analysis controlled by N stage and histologic tumor type showed that patients with high HAS-3 expression in pre-neoplastic cells obtained by lung/bronchial biopsy presented a significantly higher risk of death (HR=1.19; P=0.04). We concluded that localization of Hyal and HAS in lung/bronchial pre-neoplastic and neoplastic lesions was inversely related to malignancy, which implied that visualizing these factors could be a useful diagnostic procedure for suspected lung cancer. Finalizing this conclusion will require a wider study in a randomized and prospective trial.


Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Brônquicas/enzimologia , Carcinoma de Células Escamosas/enzimologia , Glucuronosiltransferase/metabolismo , Hialuronoglucosaminidase/metabolismo , Neoplasias Pulmonares/enzimologia , Proteínas de Neoplasias/metabolismo , Lesões Pré-Cancerosas/enzimologia , Neoplasias Brônquicas/patologia , Carcinoma de Células Escamosas/patologia , Moléculas de Adesão Celular/análise , Hialuronoglucosaminidase/análise , Hiperplasia/enzimologia , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Neoplasias Pulmonares/patologia , Análise Multivariada , Metaplasia/enzimologia , Prognóstico , Lesões Pré-Cancerosas/patologia , Índice de Gravidade de Doença , Estatísticas não Paramétricas
20.
Arch. endocrinol. metab. (Online) ; 59(5): 466-469, Oct. 2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-764117

RESUMO

Hyperinsulinemia, diagnosed by laboratory tests, should be diagnosed and treated as soon as possible to prevent fatal complications such as neurological damage. Patients who are resistant to medical therapy should be treated surgically. Minimally invasive surgery, a newly developed approach, is a good choice among surgical procedures to avoid unnecessary extensive pancreatectomy. Here, a 12-year-old boy is presented with diagnosis of hyperinsulinemic hypoglycemia who had recurrent attacks of hypoglycemia and seizures from infancy. Because of his unresponsiveness to medical therapy and his family’s preference, he underwent laparoscopic pancreatectomy to reduce morbidity and hospital stay. Two years postsurgical follow-up revealed a normo-glycemic state.


Assuntos
Criança , Humanos , Masculino , Hiperinsulinismo Congênito/cirurgia , Pâncreas/patologia , Hiperinsulinismo Congênito/patologia , Hiperplasia/patologia , Laparoscopia/métodos , Sobrepeso , Pancreatectomia/métodos , Resultado do Tratamento
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA