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Braz. j. med. biol. res ; 34(9): 1185-1190, Sept. 2001. graf
Artigo em Inglês | LILACS | ID: lil-290395

RESUMO

Non-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed ligands binding to I-R/alpha2-AR such as guanabenz (40 nmol) and UK 14304 (20 nmol) inhibited water intake by 65 percent and up to 95 percent, respectively. The selective non-imidazoline alpha2-AR agonist, alpha-methylnoradrenaline, produced inhibition of water intake similar to that obtained with guanabenz, but at higher doses (80 nmol). The non-adrenergic I-R ligands histamine (160 nmol, mixed histaminergic and imidazoline ligand) and imidazole-4-acetic acid (80 nmol, imidazoline ligand) did not alter water intake. The results show that selective, non-imidazoline alpha2-AR activation suppresses water intake, and suggest that the action on imidazoline sites by non-adrenergic ligands is not sufficient to inhibit water intake


Assuntos
Animais , Masculino , Ratos , Ingestão de Líquidos/efeitos dos fármacos , Guanidinas/farmacologia , Imidazóis/farmacologia , Nordefrin/farmacologia , Quinoxalinas/farmacologia , Receptores Adrenérgicos alfa 2/fisiologia , Imidazóis/agonistas , Injeções Intraventriculares , Ligantes , Ratos Sprague-Dawley , Vasoconstritores/farmacologia , Privação de Água
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