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1.
Braz. oral res. (Online) ; 32: e25, 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-889489

RESUMO

Abstract The objective of this study was to evaluate the in vitro effects, including surface morphological characteristics and chemical elemental properties, of different mouthwash formulations on enamel and dental restorative materials, simulating up to 6 months of daily use. Human enamel samples, hydroxyapatite, composite resin, and ceramic surfaces were exposed to 3 different mouthwashes according to label directions — Listerine® Cool Mint®, Listerine® Total Care, and Listerine® Whitening — versus control (hydroalcohol solution) to simulate daily use for up to 6 months. The samples were analyzed using scanning electron microscopy (SEM), infrared spectrophotometry (µ-Fourier transform infrared microscopy), energy-dispersive X-ray (EDX) spectroscopy, and color analysis before and after exposure. No relevant changes were observed in the morphological characteristics of the surfaces using SEM techniques. The physical and chemical aspects of the enamel surfaces were evaluated using mid-infrared spectroscopy, and EDX fluorescence was used to evaluate the elemental aspects of each surface. There was no variation in the relative concentrations of calcium and phosphorus in enamel, silicon and barium in composite resin, and silicon and aluminum in the ceramic material before and after treatment. No relevant changes were detected in the biochemical and color properties of any specimen, except with Listerine® Whitening mouthwash, which demonstrated a whitening effect on enamel surfaces. Long-term exposure to low pH, alcohol-containing, and peroxide-containing mouthwash formulations caused no ultra-structural or chemical elemental changes in human enamel or dental restorative materials in vitro.


Assuntos
Humanos , Cerâmica , Resinas Compostas , Esmalte Dentário/efeitos dos fármacos , Durapatita , Etanol/química , Etanol/farmacologia , Antissépticos Bucais/química , Antissépticos Bucais/farmacologia , Salicilatos , Terpenos , Cor , Colorimetria , Combinação de Medicamentos , Peróxido de Hidrogênio/química , Imersão , Teste de Materiais , Microscopia Eletrônica de Varredura , Óleos Voláteis/química , Valores de Referência , Reprodutibilidade dos Testes , Espectrometria por Raios X , Espectroscopia de Infravermelho com Transformada de Fourier , Propriedades de Superfície/efeitos dos fármacos , Fatores de Tempo
2.
An. bras. dermatol ; 92(2): 212-216, Mar.-Apr. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-838068

RESUMO

Abstract: Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris. Superficial chemical peeling is a skin-wounding procedure which might cause some potentially undesirable adverse events. This study was conducted to review the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris. It is a structured review of an earlier seven articles meeting the inclusion and exclusion criteria. The clinical assessments were based on pretreatment and post-treatment comparisons and the role of superficial chemical peeling in reduction of papules, pustules and comedones in active acne vulgaris. This study showed that almost all patients tolerated well the chemical peeling procedures despite a mild discomfort, burning, irritation and erythema have been reported; also the incidence of major adverse events was very low and easily manageable. In conclusion, chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid


Assuntos
Humanos , Abrasão Química/métodos , Acne Vulgar/terapia , Ácido Salicílico/uso terapêutico , Glicolatos/uso terapêutico , Ceratolíticos/uso terapêutico , Abrasão Química/efeitos adversos , Salicilatos , Resultado do Tratamento , Eritema/etiologia
3.
Braz. J. Pharm. Sci. (Online) ; 53(1): e15239, 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-839464

RESUMO

Abstract Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C. albicans activity of thiosemicarbazide, 1,3,4-Thiadiazole, and 1,2,4-triazole-3(4H)-thione compounds (compounds 3-23) were investigated. The MIC values of thiadiazole and triazole derivatives 10-23 were in the range of 0.08-0.17 µmol mL-1, while that of fluconazole was 0.052 µmol mL-1. Compound 11 (5-(2-(4-chlorobenzyloxy)phenyl)-N-allyl-1,3,4-thiadiazol-2-amine) and compound 18 (5-(2-(4-chlorobenzyloxy)phenyl)-4-allyl-2H-1,2,4-triazole-3(4H)-thione) were found to be the most active compounds, with MIC values of 0.08 µmol mL-1. The newly synthesized thiadiazole and triazole compounds (compounds 10-23) showed promising anti-Candida activity. The allyl substituent-bearing compounds 11 and 18 exhibited significant anti-Candida albicans activity and showed a binding mode as well as the fluconazole x-ray structure.


Assuntos
Tiadiazóis/síntese química , Triazóis/síntese química , Candida albicans/isolamento & purificação , Salicilatos/farmacologia , Simulação de Acoplamento Molecular , Infecções Fúngicas Invasivas/prevenção & controle
4.
Salud(i)ciencia (Impresa) ; 22(3): 229-235, oct. 2016. graf., tab.
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1097194

RESUMO

Introducción y objetivos: A pesar de que el estudio Antiplatelet Trialists' Collaboration demostró una reducción del 25% de los eventos mayores con el uso de aspirina en enfermos de alto riesgo, un porcentaje de pacientes presentan eventos isquémicos recurrentes. Esto ha llevado a la descripción de la "resistencia a la aspirina" con una tasa muy variable, de 0.4% a 83%. Este estudio evaluó la variabiliad en la función plaquetaria basal, la prevalencia de la resistencia a la aspirina, y la efectividad y reproducibilidad de los estudios de función plaquetaria. Materiales y métodos: Se llevó a cabo un estudio aleatorizado y cruzado de mediciones repetidas, con sujetos saludables de entre 18 y 60 años. Luego de firmar el consentimiento informado, los pacientes fueron distribuidos en forma aleatorizada a recibir aspirina en dosis de 75 mg o 300 mg; fueron evaluados al inicio y luego de cuatro períodos de tres semanas mediante diferentes técnicas: Optical Platelet Aggregation (OPA), PFA-100™, VerifyNow™, y los niveles séricos y urinarios de tromboxano B2 (TXB2). Se obtuvo la aprobación del comité de ética local. El análisis estadístico fue realizado con el programa SPSS17. Resultados: El índice global de resistencia a la aspirina fue variable, entre 2.4% y 63.5% en función de la técnica utilizada. Se demostró una variabilidad interindividual e intraindividual significativa al inicio y con la administración de placebo en las diferentes técnicas. La sensibilidad de los ensayos varió entre 24% (OPA ADP10) y 87.8% (tromboxano sérico), y la especificidad varió entre 81% (PFA-100™) y 97.4% (tromboxano). La selección de "valores de corte" alternativos provocó tasas de prevalencia diferentes de resistencia bioquímica a la aspirina, con un mecanismo de compensación entre la sensibilidad y la especificidad. Conclusiones: La respuesta a la aspirina mostró una marcada variabilidad interensayo, interindividual y temporal. Se requieren varias evaluaciones con diferentes técnicas para diagnosticar en forma confiable la resistencia a la aspirina. La selección de valores discriminativos alternativos debería considerarse al evaluar formalmente esta entidad


Introduction: Despite the 25% reduction in major events with aspirin in high-risk patients reported by the Antiplatelet Trialists' Collaboration, a proportion of patients develop recurrent ischaemic events. This has led to the emergence of 'aspirin resistance' with rates between 0.4% and 83% reported. This study assessed variability in baseline platelet function, prevalence of aspirin resistance, and the performance and reproducibility of platelet function testing methods. Materials and Methods: A repeated-measures randomised crossover study was performed in healthy individuals aged 18-60 years. After informed consent, patients were randomised to aspirin dose (75 mg or 300 mg) and treatment sequence with testing at baseline and after each four 3-week treatment period via Optical Platelet Aggregation (OPA), PFA-100™, VerifyNow™, and serum and urinary thromboxane (TXB2) levels. Local ethical approval was granted. Statistical analysis was performed using SPSS17. Results: The overall rate of aspirin resistance varied from 2.4% to 63.5% depending on the assay used. Significant inter- and intra-individual variability existed at baseline and on placebo testing between assays. Assay sensitivities ranged from 24.0% (OPA ADP10) to 87.8% (serum TXB2), and specificities from 81.0% (PFA-100™) to 97.4% (serum TXB2). Selection of alternative "cut-off" values resulted in differing prevalence rates of biochemical aspirin resistance with a trade-off between sensitivity and specificity. Conclusions: Response to aspirin shows marked inter-assay, inter-individual and temporal variability. Testing on multiple occasions using several assays is necessary to reliably diagnose aspirin resistance. Selection of alternative assay "cut-off" values should be considered when formally assessing aspirin response


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Testes de Função Plaquetária , Inibidores da Agregação de Plaquetas , Salicilatos , Aspirina
5.
Pesqui. bras. odontopediatria clín. integr ; 14(3): 191-198, jul. 2014. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-853659

RESUMO

Objective:To evaluate the antimicrobial and ant-adherent in vitro activity of tannins isolated from Anacardium occidentale Linn. (Cashew) on dental biofilm bacteria. Material and Methods:Streptococcus mutans ATCC 25175, Streptococcus mitis ATCC 903, Streptococcus sanguis ATCC 15300, Streptococcus oralis ATCC 10557, Streptococcus salivarius ATCC 7073 and Lactobacillus casei ATCC 9595 samples were used in this study. The tests were performed by the solid medium dilution method to determine the Minimum Inhibitory Concentration (MIC). The Minimum Inhibitory Concentration of Adherence (MICA) of bacteria to glass was determined in the presence of 5% sucrose. As a positive control, 0.12% chlorhexidine gluconate was used. The substances were tested at concentrations of 1:1 (pure solution) up to 1:512. Data were analyzed using descriptive statistics and the SPSS software,version 15.0. Results:Tannins isolated from Anacardium occidentale Linn. (cashew) formed inhibition halos ranging from 11 to 17 mm in diameter and were capable of inhibiting the growth of bacteria tested at concentrations of 1:4 (S mutans), 1:16 (S mitis), 1:8 (Ssanguis), 1:4 (S oralis), 1:8 (S salivarius) and 1:2 (L casei). The tannin solution was effective in inhibiting the adherence of microorganisms to glass, and its effect on Streptococcus sanguis (1:512) and Lactobacillus casei (1:512) stood out, showing ant-adherent effect at all concentrations tested. Conclusion:Tannin isolates produced in vitro antimicrobial and ant-adherent activity on dental biofilm-forming bacteria and can be considered as an alternative treatment in infectious processes in clinical dentistry


Assuntos
Anacardium , Antibacterianos , Fitoterapia , Placa Dentária/microbiologia , Salicilatos , Brasil , Análise Estatística , Técnicas In Vitro/métodos
6.
Braz. dent. j ; 26(4): 357-362, July-Aug. 2015. tab, ilus
Artigo em Inglês | LILACS | ID: lil-756388

RESUMO

The purpose of this study was to evaluate the water sorption, solubility, pH and ability to diffuse into dentin of a glycerol salicylate-based, pulp-capping cement in comparison to a conventional calcium hydroxide-based pulp capping material (Hydcal). An experimental cement was developed containing 60% glycerol salicylate resin, 10% methyl salicylate, 25% calcium hydroxide and 5% Portland cement. Water sorption and solubility were determined based on mass changes in the samples before and after the immersion in distilled water for 7 days. Material discs were stored in distilled water for 24 h, 7 days and 28 days, and a digital pHmeter was used to measure the pH of water. The cement's ability to diffuse into bovine dentin was assessed by Raman spectroscopy. The glycerol salicylate-based cement presented higher water sorption and lower solubility than Hydcal. The pH of water used to store the samples increased for both cements, reaching 12.59±0.06 and 12.54±0.05 after 7 days, for Hydcal and glycerol salicylate-based cements, respectively. Both cements were able to turn alkaline the medium at 24 h and sustain its alkalinity after 28 days. Hydcal exhibited an intense diffusion into dentin up to 40 µm deep, and the glycerol salicylate-based cement penetrated 20 µm. The experimental glycerol salicylate-based cement presents good sorption, solubility, ability to alkalize the surrounding tissues and diffusion into dentin to be used as pulp capping material.

.

O objetivo deste estudo foi avaliar a sorção e solubilidade em água, pH e habilidade de difusão na dentina de um cimento para capeamento pulpar à base de glicerol salicilato e compará-lo a um cimento comercial para capeamento pulpar à base de hidróxido de cálcio (Hydcal). Um cimento experimental contendo 60% de resina de glicerol salicilato, 10% de salicilato de metila, 25% de hidróxido de cálcio e 5% de cimento Portland foi formulado. Sorção e solubilidade em água foram determinadas a partir da alteração na massa de espécimes antes e após a imersão em água destilada por 7 dias. Discos dos cimentos foram armazenados em água destilada por 24h, 7 dias e 28 dias e o pH da água foi aferido após cada período. A habilidade de difundir-se no interior de dentina bovina foi avaliada por espectroscopia Raman. O cimento à base de glicerol salicilato apresentou maior sorção e menor solubilidade em comparação com o Hydcal. O pH da água de armazenamento dos espécimes aumentou para ambos os cimentos, chegando a 12,59±0,06 e 12,54±0,05 após 7 dias, para o Hydcal e o cimento à base de glicerol salicilato, respectivamente. Os cimentos foram capazes de promover a alcalinização do meio após 24h e sustentaram a alcalinidade após 28 dias. Hydcal exibiu intensa difusão na dentina até 40 μm de profundidade e o cimento à base de glicerol salicilato penetrou 20 μm. O cimento experimental à base de glicerol salicilato apresentou adequada sorção, solubilidade, habilidade de alcalinizar o meio e difundir-se no interior da dentina para uso como um material para capeamento pulpar.

.


Assuntos
Capeamento da Polpa Dentária/instrumentação , Glicerol/química , Salicilatos/química
7.
Braz. oral res. (Online) ; 29(1): 1-7, 2015. tab, ilus
Artigo em Inglês | LILACS | ID: lil-777235

RESUMO

The objective of this study was to describe a new method for the quantitative analysis of a microleakage of endodontic filling materials. Forty extracted single-rooted teeth were randomly divided into three experimental groups. After root canal shaping, the experimental groups were filled using the lateral condensation technique with the Epiphany system (G1), with gutta-percha + Sealapex (G2), and with gutta-percha + AH Plus (G3). Each root was mounted on a modified leakage testing device, and caffeine solution was used as a tracer (2000 ng mL-1, pH 6.0), applied in the coronal direction towards the tooth apex, creating a hydrostatic pressure of 2.55 kPa. Presence of caffeine in the receiving solution was measured after 10, 30, and 60 days, using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). None of the groups presented microleakage at 10 days. At 30 days, G2 and G3 showed similar infiltration patterns (means: 16.0 and 13.9 ng mL-1, respectively), whereas G1 showed significantly higher values (mean: 105.2 ng mL-1). At 60 days, leakage values were 182.6 ng mL-1for G1, 139.0 ng mL-1 for G2, and 53.5 ng mL-1 for G3. AH Plus showed the best sealing ability and HPLC-MS/MS showed high sensitivity and specificity for tracer quantification.


Assuntos
Humanos , Infiltração Dentária/diagnóstico , Obturação do Canal Radicular/métodos , Preparo de Canal Radicular/métodos , Hidróxido de Cálcio , Cromatografia Líquida , Infiltração Dentária/prevenção & controle , Resinas Epóxi , Guta-Percha , Distribuição Aleatória , Materiais Restauradores do Canal Radicular , Obturação do Canal Radicular/instrumentação , Preparo de Canal Radicular/instrumentação , Salicilatos , Espectrometria de Massas em Tandem
8.
Braz. oral res. (Online) ; 29(1): 1-7, 2015. tab
Artigo em Inglês | LILACS | ID: lil-777211

RESUMO

This in vitro study aimed to determine the susceptibility of oral specimens and ATCC lineages of Candida albicans for five endodontic sealers, which were pure and associated with two antifungal drugs, and to analyze their effect on the physical properties. For this purpose, 30 lineages of C. albicans, collected from the oral cavity of patients assisted at the endodontics clinic of the Universidade Sagrado Coração, were analyzed. Yeasts susceptibility to the sealers was tested by diffusion on agar plates. Physical properties were evaluated according to the ADA specification no. 57. The pure versions of the Sealer 26, AH Plus, Endofill, Fillapex, and Sealapex demonstrated antifungal activity, with Endofill presenting the greatest inhibition zones. All cements, except for Endofill, had their antifungal actions enhanced by addition of ketoconazole and fluconazole (p < 0.05), and the AH Plus presented the best antifungal activity. The addition of antifungal drugs did not interfere with the setting time and flowability of the sealers. It was concluded that the addition of antifungals to endodontic sealers enhanced the antimicrobial action of most cements tested without altering their physical properties.


Assuntos
Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Fluconazol/farmacologia , Cetoconazol/farmacologia , Materiais Restauradores do Canal Radicular/farmacologia , Antifúngicos/química , Bismuto/química , Bismuto/farmacologia , Hidróxido de Cálcio/química , Hidróxido de Cálcio/farmacologia , Candida albicans/isolamento & purificação , Resinas Epóxi/química , Resinas Epóxi/farmacologia , Fluconazol/química , Cetoconazol/química , Testes de Sensibilidade Microbiana , Reprodutibilidade dos Testes , Materiais Restauradores do Canal Radicular/química , Estatísticas não Paramétricas , Salicilatos/química , Salicilatos/farmacologia
9.
J. bras. med ; 102(4)julho - agosto 2014. graf, ilus, tab
Artigo em Português | LILACS | ID: lil-725929

RESUMO

Retocolite ulcerativa inespecífica (RCU) e doença de Crohn (DC) são consideradas as principais doenças inflamatórias intestinais idiopáticas (DIIs). De etiologia ainda desconhecida, evoluem, clinicamente, por surtos recorrentes, intercalando episódios de atividade inflamatória, acompanhados de manifestações digestivas e extradigestivas, com períodos de remissão, ambos imprevisíveis...


Nonspecific ulcerative recolitis (NUC) and Chron's Disease (CD) are considered the mainly idiopathic inflammatory bowel disease (IBD). Etiology unknown, the nonspecific ulcerative recolitis has a clinical proceed, by recurrent outbreaks, episodes of intercalated inflammatory activity, following by digestive and extra digestive symptoms, with period of remission, both of them are unpredictable...


Assuntos
Humanos , Masculino , Feminino , Doenças Inflamatórias Intestinais/diagnóstico , Doenças Inflamatórias Intestinais/epidemiologia , Doenças Inflamatórias Intestinais/terapia , Anemia/etiologia , Apendicectomia/efeitos adversos , Colite Ulcerativa/diagnóstico , Corticosteroides/uso terapêutico , Diagnóstico Diferencial , Diagnóstico por Imagem , Técnicas de Diagnóstico do Sistema Digestório , Surtos de Doenças , Doença de Crohn/diagnóstico , Fumar/efeitos adversos , Imunossupressores/uso terapêutico , Salicilatos/uso terapêutico , Técnicas de Laboratório Clínico
10.
J. appl. oral sci ; 21(3): 235-242, May/Jun/2013. graf
Artigo em Inglês | LILACS | ID: lil-679324

RESUMO

Some manufacturers have recently added specific components to improve the ease of handling and insertion material properties of MTA in order to create MTA-based sealers. Objective The aim of this study was to evaluate the healing of periapical lesions in canine teeth after a single session of endodontic treatment with MTA Fillapex® compared with Sealapex® or Endo-CPM-Sealer®. Material and Methods Sixty-two root canals were performed on two 1-year-old male dogs. After coronal access and pulp extirpation, the canals were exposed to the oral cavity for 6 months in order to induce periapical lesions. The root canals were prepared, irrigated with a solution of 2.5% sodium hypochlorite and filled with gutta-percha and different sealers, according to the following groups: 1) Sealapex®; 2) Endo-CPM-Sealer®; and 3) MTA Fillapex®. Some teeth with periapical lesions were left untreated for use as positive controls. Healthy teeth were used as negative controls. After 6 months, the animals were sacrificed and serial sections from the roots were prepared for histomorphologic analysis and stained with hematoxylin and eosin and the Brown and Brenn technique. The lesions were scored according to pre-established histomorphologic parameters and the scores statistically analyzed using the Kruskal-Wallis test. Results All 3 materials produced similar patterns of healing (p>0.05); in particular, persistent inflammation and absence of complete periapical tissue healing were consistently noted. Conclusions Preparation of the infected root canals followed by filling with the materials studied was insufficient to provide complete healing of the periapical tissues. .


Assuntos
Animais , Cães , Masculino , Compostos de Alumínio/uso terapêutico , Compostos de Cálcio/uso terapêutico , Hidróxido de Cálcio/uso terapêutico , Óxidos/uso terapêutico , Tecido Periapical/efeitos dos fármacos , Materiais Restauradores do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/métodos , Salicilatos/uso terapêutico , Silicatos/uso terapêutico , Cicatrização/efeitos dos fármacos , Anti-Infecciosos/uso terapêutico , Combinação de Medicamentos , Cavidade Pulpar/efeitos dos fármacos , Cavidade Pulpar/microbiologia , Teste de Materiais , Tecido Periapical/lesões , Tecido Periapical/patologia , Reprodutibilidade dos Testes , Irrigantes do Canal Radicular/uso terapêutico , Fatores de Tempo
11.
Braz. dent. j ; 24(2): 107-110, Mar-Apr/2013. graf
Artigo em Inglês | LILACS | ID: lil-675667

RESUMO

Despite the excellent properties of mineral trioxide aggregate (MTA), the condensation technique may have some influence in its sealing ability. The purpose of this study was to compare the sealing ability of sonic and ultrasonic setting of MTA. Thirty-four extracted human teeth had their canals prepared and filled with Sealapex sealer and gutta-percha using the active lateral condensation technique. The teeth were rendered waterproof and apicoectomy performed at 3 mm from the apex. Root-end cavities (3.0 mm deep and 1.4 mm diameter) were prepared with diamond ultrasonic tips. The root-end cavities were filled with Pro-Root MTA® with ultrasonic vibration, sonic vibration or no vibration. The positive control group did not receive any material while the negative control group was totally rendered waterproof. After material set, the specimens were immersed in Rodhamine B for 24 h, under vacuum in the first 15 min, then washed, dried and split longitudinally for evaluating the infiltration at the dentin/material interface. Data were analyzed using ANOVA and Tukey's tests at 5% significance level. Sonic vibration promoted the lowest infiltration values (p<0.05). It was concluded that sonic vibration could be considered an efficient aid to improve the sealing ability of MTA when used as root-end filling material.


Resumo O objetivo deste estudo foi avaliar in vitro, a influência da vibração sônica e ultrassônica no selamento marginal proporcionado pelo MTA. Trinta e quatro dentes humanos tiveram seus canais radiculares instrumentados e obturados com cimento Sealapex® pela técnica da condensação lateral ativa. Os dentes foram impermeabilizados e seccionados os 3 mm apicais. Retrocavidades (3 mm de profundidade e 1,4 mm de diâmetro) foram preparadas com pontas ultrassônicas diamantadas. As retrocavidades foram preenchidas com Pro-Root MTA® com auxílio da vibração ultrassônica, com auxílio da vibração sônica e sem vibração alguma. O grupo controle positivo não recebeu material retrobturador, enquanto que o negativo foi totalmente impermeabilizado. Após a presa do material, os espécimes foram mergulhados em Rodamina B por 15 min em vácuo, permanecendo nesta solução por mais 24 h. Em seguida, foram lavados, secados e clivados longitudinalmente para avaliação da infiltração do corante na interface dentina/material retrobturador. Os dados foram analisados utilizando a análise de variância e o teste de Tukey (p<0,05). Observou-se que apenas a vibração sônica foi diferente apresentando os menores índices de infiltração. Pode-se concluir que vibração sônica contribui com a melhora da capacidade de selamento marginal proporcionado pelo MTA quando empregado como material retrobturador. .


Assuntos
Humanos , Compostos de Alumínio/uso terapêutico , Compostos de Cálcio/uso terapêutico , Colagem Dentária , Óxidos/uso terapêutico , Obturação Retrógrada/métodos , Materiais Restauradores do Canal Radicular/uso terapêutico , Silicatos/uso terapêutico , Apicectomia/métodos , Hidróxido de Cálcio/uso terapêutico , Combinação de Medicamentos , Dentina/ultraestrutura , Diamante/química , Corantes Fluorescentes , Guta-Percha/uso terapêutico , Rodaminas , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Sonicação , Propriedades de Superfície , Salicilatos/uso terapêutico , Fatores de Tempo , Ultrassom/instrumentação , Vibração
12.
Arq. bras. cardiol ; 100(1): 29-36, jan. 2013. ilus, tab
Artigo em Português | LILACS | ID: lil-662392

RESUMO

FUNDAMENTO: A aspirina (Ácido Acetilsalicílico - AAS) é capaz de reduzir eventos adversos cardiovasculares em pacientes portadores de Doença Arterial Coronariana (DAC) através da inibição da atividade plaquetária. Alguns pacientes com DAC, apesar da terapia com AAS, apresentam Alta Reatividade Plaquetária (ARP), o que determina um maior risco para o desenvolvimento de eventos cardiovasculares. OBJETIVO: O objetivo deste estudo foi determinar a prevalência de ARP em pacientes tratados com AAS e encaminhados para cinecoronariografia, além de avaliar se existe uma possível correlação entre a gravidade da DAC e o desenvolvimento de ARP. MÉTODOS: Estudo de centro único onde foram incluídos 115 pacientes consecutivos, tratados com AAS e portadores de DAC estável. A reatividade plaquetária induzida pelo ADP e colágeno foram avaliadas através da Agregometria de Transmitância Luminosa (ATL). Pacientes com agregação plaquetária maior que 70%, induzida por ambos os reagentes, foram classificados como tendo ARP e, neste grupo, a adesão ao tratamento com AAS foi avaliada através da dosagem dos níveis séricos de salicilato. RESULTADOS: A média de idade foi de 60,9 anos e a dose média de AAS foi de 164,2 mg. Tabagismo e diabetes melito estavam presentes em 28,7% e 31,5% dos pacientes, respectivamente. Foi encontrada ARP em 14 pacientes (13%), entretanto, em sete indivíduos (50%) com ARP observaram-se baixos níveis séricos de salicilato (< 2,0 µg/mL), sugerindo não adesão à terapia medicamentosa. Em 6,5% dos pacientes com ARP identificou-se níveis detectáveis de salicilato sérico, sugerindo uma eficácia reduzida do AAS. A ARP se correlacionou com o número e a gravidade das estenoses coronárias (p = 0,04). CONCLUSÃO: Em uma população de pacientes tratados com AAS e encaminhados para angiografia coronária, a reatividade plaquetária elevada é prevalente (13%), sendo 50% destes pacientes não aderentes à terapia farmacológica e 50% apresentam redução da efetividade da droga.


BACKGROUND: Aspirin (ASA) reduces adverse events in coronary artery disease (CAD) patients by inhibiting platelets. Some CAD patients have high platelet reactivity (HPR) despite ASA therapy and these individuals have increased risk of adverse events. OBJECTIVE: The purpose of this study was to determine the prevalence of HPR in ASA-treated patients referred for coronary angiography and to assess whether the HPR correlates with the severity of CAD. METHODS: This single center investigation enrolled 115 consecutive ASA-treated patients with stable CAD. ADP- and collagen-induced platelet reactivity were evaluated by light transmittance aggregometry (LTA). Patients with greater than 70% ADP- and collagen-induced aggregation were determined to have HPR and, in this group, ASA compliance was assessed by examining blood salicylate levels. Mean age was 60.9 years and average ASA dose was 164.2 mg. RESULTS: Smoking and DM were present in 28.7% and 31.5% respectively. HPR was found in 14 patients (13%) however 7 of the 14 patients (50%) with HPR had low serum salicylate levels (< 2.0 µg/mL) suggesting medication noncompliance. Of the entire cohort, 6.5% of patients had HPR and detectable serum salicylate levels suggesting reduced ASA efficacy. HPR correlated with number and severity of coronary stenosis (p = 0.04). CONCLUSION: In a general population of ASA-treated patients referred for coronary angiography, elevated platelet reactivity is prevalent (13%) with 50% related to noncompliance and 50% related to reduced aspirin efficacy.


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Aspirina/administração & dosagem , Angiografia Coronária , Doença da Artéria Coronariana/tratamento farmacológico , Inibidores da Agregação de Plaquetas/administração & dosagem , Agregação Plaquetária/efeitos dos fármacos , Colágeno/sangue , Doença da Artéria Coronariana/complicações , Resistência a Medicamentos , Fatores de Risco , Salicilatos/sangue
13.
J. appl. oral sci ; 21(1): 43-47, 2013. tab, graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: lil-684994

RESUMO

Objectives: The aim of the present study was to investigate the effects of root canal sealers on the cytotoxicity of 3T3 fibroblasts during a period of 5 weeks. Material and Methods: Fibroblasts (3T3, 1×105 cells per well) were incubated with elutes of fresh specimens from eight root canal sealers (AH Plus, Epiphany, Endomethasone N, EndoREZ, MTA Fillapex, Pulp Canal Sealer EWT, RoekoSeal and Sealapex) and with elutes of the same specimens for 5 succeeding weeks after immersing in simulated body fluid. The cytotoxicity of all root canal sealers was determined using the MTT assay. Data were analyzed using ANOVA and Tukey's test. Results: RoekoSeal was the only sealer that did not show any cytotoxic effects (p<0.05). All the other tested sealers exhibited severe toxicity initially (week 0). MTA Fillapex remained moderately cytotoxic after the end of experimental period. Toxicity of the other tested sealers decreased gradually over time. The evaluated root canal sealers presented varying degrees of cytotoxicity, mainly in fresh mode.Conclusions: RoekoSeal had no cytotoxic effect both freshly mixed and in the other tested time points. MTA Fillapex was associated with significantly less cell viability when compared to the other tested root canal sealers.


Assuntos
Animais , Camundongos , /efeitos dos fármacos , Materiais Restauradores do Canal Radicular/toxicidade , Materiais Biocompatíveis/toxicidade , Hidróxido de Cálcio/toxicidade , Sobrevivência Celular/efeitos dos fármacos , Resinas Compostas/toxicidade , Combinação de Medicamentos , Cimentos Dentários/toxicidade , Dexametasona/toxicidade , Resinas Epóxi/toxicidade , Formaldeído/toxicidade , Hidrocortisona/toxicidade , Salicilatos/toxicidade , Fatores de Tempo , Timol/análogos & derivados , Timol/toxicidade
14.
Braz. oral res ; 26(5): 424-430, Sept.-Oct. 2012. graf, tab
Artigo em Inglês | LILACS | ID: lil-649362

RESUMO

The aim of this work was to evaluate the effects of different times of extraction on the cytotoxicity of six representatives of different root canal sealer groups-Real Seal SE, AH Plus, GuttaFlow, Sealapex, Roth 801, and ThermaSeal Plus-with human gingival fibroblasts. The materials were prepared according to manufacturers' specifications, and were incubated in culture medium (DMEM) at 37ºC for 1, 7, 14, 21, and 28 days, with daily washing, to simulate periodontal ligament clearance. Human fibroblasts were exposed to the final extracts at 24 hours, and cell viability was determined by MTT assay, with exposure to unconditioned DMEM as a negative control. Statistical analysis comparing cytotoxicities at each exposure time was performed by ANOVA with Scheffé adjustment for multiple comparisons at a 95% confidence level. Results indicated that GuttaFlow was significantly less cytotoxic than all other sealers (p < 0.05) at 1 day of extraction. After 7 days of extraction, cell viability for GuttaFlow was significantly increased as compared with that of all groups except sealer AH Plus. At day 14, cytotoxicity of Sealapex was significantly higher than that of all other sealers (p < 0.05). At days 21 and 28, there were no significant differences in cytotoxicity among sealer groups. All materials presented some level of cytotoxicity to fibroblasts, while GuttaFlow was the least cytotoxic sealer tested. However, the cytotoxicity of all materials seemed to decrease similarly in a time-dependent manner.


Assuntos
Humanos , Fibroblastos/efeitos dos fármacos , Materiais Restauradores do Canal Radicular/toxicidade , Análise de Variância , Sobrevivência Celular , Células Cultivadas , Hidróxido de Cálcio/toxicidade , Resinas Compostas/toxicidade , Combinação de Medicamentos , Dimetilpolisiloxanos/toxicidade , Resinas Epóxi/toxicidade , Guta-Percha/toxicidade , Teste de Materiais , Salicilatos/toxicidade , Fatores de Tempo
15.
J. appl. oral sci ; 20(4): 455-461, July-Aug. 2012. tab
Artigo em Inglês | LILACS | ID: lil-650623

RESUMO

OBJECTIVE: To assess the setting time (ST), flow (FL), radiopacity (RD), solubility (SB) and dimensional change following setting (DC) of different sealers (AH Plus®, Polifil, Apexit Plus®, Sealapex®, Endométhasone® and Endofill®) according to American National Standards Institute/American Dental Association (ANSI/ADA) Specification 57. MATERIAL AND METHODS: Five samples of each material were used for each test. For ST, cast rings were filled with sealers and tested with a Gilmore needle. For FL, the sealer was placed on a glass plate. After 180 s, another plate with 20 g and a load of 100 g were applied on the material, and the diameters of the discs formed were measured. In RD, circular molds were filled with the sealers, radiographed and analyzed using Digora software. For SB, circular molds were filled with the sealers, a nylon thread was placed inside the material and another glass plate was positioned on the set, pressed and stored at 37°C. Samples were weighed, placed in water, dried and reweighed. The water used for SB was analyzed by atomic absorption spectrometry. For DC, circular molds were filled with the sealers, covered by glass plates and stored at 37°C. Samples were measured and stored in water for 30 days. After this period, they were dryed and measured again. RESULTS: Regarding ST, AH Plus®, Apexit® and Endofil® sealers are in accordance with ANSI/ADA standards. Endométhasone's manufacturer did not mention the ST; Polifil is an experimental sealer and Sealapex® did not set. Considering RD, SB and DC, all sealers were in accordance with ANSI/ADA. The spectrometric analysis showed that a significant amount of K+ and Zn2+ ions was released from Apexit Plus® and Endofill®, respectively. CONCLUSION: Except for DC, all other physicochemical properties of the tested sealers conformed to ANSI/ADA requirements.


Assuntos
Humanos , Materiais Restauradores do Canal Radicular/química , American Dental Association , Análise de Variância , Hidróxido de Cálcio/química , Combinação de Medicamentos , Dexametasona/química , Resinas Epóxi/química , Formaldeído/química , Hidrocortisona/química , Teste de Materiais , Materiais Restauradores do Canal Radicular/normas , Solubilidade , Estatísticas não Paramétricas , Propriedades de Superfície , Salicilatos/química , Fatores de Tempo , Timol/análogos & derivados , Timol/química , Estados Unidos
16.
J. appl. oral sci ; 20(3): 347-351, May-June 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-643732

RESUMO

OBJECTIVES: The aim of this study was to evaluate the apical sealability of Fillapex®, endo-CPM-Sealer® and Sealapex®. Material and Methods: Ninety-four freshly extracted single-rooted teeth were selected and decoronated. All teeth were radiographed to confirm the existence of a single and straight root canal, which was prepared using Protaper Universal and 2.5% sodium hypochlorite. The teeth were randomly divided in groups of 10 specimens each according to the sealer, and the canals were filled using the single cone technique and one of the sealers. Four additional teeth were used as controls. The teeth were submitted to dye leakage with Rhodamine B for 24 h but using vacuum on the initial 15 min. Thereafter, they were cut longitudinally and the leakage was measured in a linear fashion from apex to crown. Data were analyzed by ANOVA and Tukey's tests at 5% significance level. Results: Fillapex® and Sealapex® showed significantly less dye leakage than endo-CPM-Sealer® (p<0.05). Conclusions: It was concluded that Fillapex® and Sealapex® were able to prevent apical dye leakage differently from endo-CPM-Sealer®.


Assuntos
Humanos , Compostos de Alumínio/química , Compostos de Cálcio/química , Hidróxido de Cálcio/química , Infiltração Dentária/prevenção & controle , Óxidos/química , Materiais Restauradores do Canal Radicular/química , Silicatos/química , Análise de Variância , Combinação de Medicamentos , Teste de Materiais , Obturação do Canal Radicular/métodos , Salicilatos/química , Fatores de Tempo , Ápice Dentário/química , Ápice Dentário/efeitos dos fármacos
17.
J. appl. oral sci ; 20(2): 260-267, Mar.-Apr. 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-626431

RESUMO

OBJECTIVE:To evaluate the discrepancy of root canal filling (RCF) measurements obtained from original root specimens and cone-beam computed tomography (CBCT) images. MATERIAL AND METHODS: Seventy-two human maxillary anterior teeth were prepared up to an ISO #50 K-File 1 mm short of the apical foramen. Thus, the teeth were randomly divided into 8 groups, according to the root canal filling material: Sealapex ®, Sealapex®+gutta-percha points, Sealer 26®, Sealer 26®+gutta-percha points, AH PlusTM, AH PlusTM+gutta-percha points, Grossman Sealer, and Grossman Sealer+gutta-percha points. After root canal preparation and RCF, CBCT scans were acquired and the specimens were sectioned in axial, sagittal and coronal planes. The RCF measurements were obtained in different planes and thicknesses to determine the discrepancy between the original root specimens (using a digital caliper) and the CBCT images (using the scanner’s proprietary software). One-way analysis of variance and Tukey tests were used for statistical analyses. The significance level was set at α=5%. RESULTS: Measurements of the different endodontic filling materials were 9% to 100% greater on the CBCT images than on the original root specimens. Greater RCF dimensions were found when only sealers were used, with statistically significant difference among the groups. CONCLUSIONS: RCF dimensions were greater on CBCT images than on the original root specimens, especially when only sealer was used.


Assuntos
Humanos , Tomografia Computadorizada de Feixe Cônico , Materiais Restauradores do Canal Radicular/química , Raiz Dentária , Análise de Variância , Bismuto/química , Hidróxido de Cálcio/química , Resinas Epóxi/química , Guta-Percha/química , Teste de Materiais , Distribuição Aleatória , Preparo de Canal Radicular , Salicilatos/química , Raiz Dentária/anatomia & histologia , Cimento de Óxido de Zinco e Eugenol/química
19.
J. appl. oral sci ; 19(4): 324-328, July-Aug. 2011. tab
Artigo em Inglês | LILACS | ID: lil-599755

RESUMO

OBJECTIVES: To evaluate the sealing ability of five root canal sealers, including two experimental cements (MBP and MTA-Obtura) using the fluid filtration method. MATERIAL AND METHODS: Teeth were divided into 5 study groups: G1-AH Plus; G2-Acroseal; G3Sealapex; G4-MBP; G5-MTA-Obtura; and two controls. Chemical-mechanical preparation was performed with ProFile rotary nickel-titanium instruments 1 mm short of the apical foramen. The sealing ability was evaluated by fluid filtration at 15, 30, and 60 days. RESULTS: The statistical analysis showed significant difference between the materials at different periods (p<0.05). AH Plus and MBP had similar leakage values at 15 and 60 days, alternating with significant reduction at 30 days, while the other materials showed progressive increase in leakage values. Acroseal and Sealapex presented the best results at 15 days and the worst at 60 days. CONCLUSIONS: All sealers evaluated presented fluid leakage, with AH Plus and MBP showing the best results at the end of the experimental period. Acroseal, Sealapex, and MTA-Obtura presented increase in leakage values at longer observation periods.


Assuntos
Humanos , Infiltração Dentária , Técnicas In Vitro , Materiais Restauradores do Canal Radicular/química , Obturação do Canal Radicular/métodos , Compostos de Alumínio/química , Compostos de Cálcio/química , Hidróxido de Cálcio/química , Combinação de Medicamentos , Guta-Percha/química , Teste de Materiais , Óxidos/química , Cimentos de Resina/química , Estatísticas não Paramétricas , Salicilatos/química , Silicatos/química , Fatores de Tempo
20.
J. appl. oral sci ; 19(4): 329-336, July-Aug. 2011. ilus, tab
Artigo em Inglês | LILACS | ID: lil-599758

RESUMO

OBJECTIVE: The aim of this study was to investigate the effects of mineral trioxide aggregate (MTA), Sealapex, and a combination of Sealapex and MTA (Sealapex Plus) on the reaction of subcutaneous connective tissue of rats, and on cell viability and cytokine production in mouse fibroblasts. MATERIAL AND METHODS: The tissue reaction was carried out with dentin tubes containing the materials implanted in the dorsal connective tissue of rats. The histological analysis was performed after 7 and 30 days. Millipore culture plate inserts with polyethylene tubes filled with materials were placed into 24-well cell culture plates with mouse fibroblasts to evaluate the cell viability by MTT assay. ELISA assays were also performed after 24 h of exposure of the mouse fibroblasts to set material disks. RESULTS: Histopathologic examination showed Von Kossa-positive granules that were birefringent to polarized light for all the studied materials at the tube openings. No material inhibited the cell viability in the in vitro test. It was detected IL-6 production in all root-end filling materials. MTA and Sealapex Plus induced a slight raise of mean levels of IL-1β. CONCLUSIONS: The results suggest that Sealapex Plus is biocompatible and stimulates the mineralization of the tissue.


Assuntos
Animais , Masculino , Ratos , Compostos de Alumínio/farmacologia , Compostos de Cálcio/farmacologia , Hidróxido de Cálcio/farmacologia , Tecido Conjuntivo/efeitos dos fármacos , Citocinas/efeitos dos fármacos , Fibroblastos/efeitos dos fármacos , Óxidos/farmacologia , Materiais Restauradores do Canal Radicular/farmacologia , Salicilatos/farmacologia , Silicatos/farmacologia , Materiais Biocompatíveis/farmacologia , Células Cultivadas , Sobrevivência Celular/efeitos dos fármacos , Combinação de Medicamentos , Dentina/efeitos dos fármacos , Ensaio de Imunoadsorção Enzimática , Teste de Materiais , Ratos Wistar , Fatores de Tempo
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