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Acta cir. bras ; 33(2): 125-133, Feb. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-886259


Abstract Purpose: To investigate the biochemical, histopathologic, and spermatogenetic changes in the detorsionated testicle after experimental torsion and to study the antioxidant effects of pheniramine maleate and nebivolol. Methods: Twenty-four Sprague-Dawley male rats were divided into 4 groups: Group 1: Sham; Group 2: Torsion/Detorsion (T/D); Group 3: T/D + Pheniramine maleate (PM); Group 4: T/D + Nebivolol (NB) group. Paroxanase (PON), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stres index (OSI) were measured, and spermatogenetic and histopathologic evaluation was performed in tissue and blood samples. Results: The evaluation of tissue TAS indicated no statistically significant difference in Group 3 compared to Group 2. A statistically significant increase was detected in Group 4 compared to Group 2. Serum PON levels revealed a statistically significant increase in Groups 3 and 4 compared to Groups 1 and 2. The Johnsen testicular biopsy score decreased in Groups 3 and 4, but the decrease was not statistically significant. Conclusions: Pheniramine maleate and nebivolol have antioxidant effects against ischemia-reperfusion damage. They also support tissue recovery, which is more significantly observed by nebivolol.

Animais , Masculino , Ratos , Feniramina/farmacologia , Torção do Cordão Espermático/tratamento farmacológico , Testículo/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Nebivolol/farmacologia , Antioxidantes/farmacologia , Torção do Cordão Espermático/patologia , Espermatogênese/efeitos dos fármacos , Testículo/irrigação sanguínea , Testículo/patologia , Fatores de Tempo , Traumatismo por Reperfusão/tratamento farmacológico , Ratos Sprague-Dawley , Antagonistas Adrenérgicos beta/farmacologia , Arildialquilfosfatase/sangue , Antagonistas dos Receptores Histamínicos H1/farmacologia
Arq. neuropsiquiatr ; 54(1): 82-93, mar. 1996. tab, ilus
Artigo em Inglês | LILACS | ID: lil-164059


Study of 22 patients with the severe form of neurocysticercosis treated with albendazole (ABZ) administered in 6 different schedules ranging from 15 to 30 mg/kg/day for 21 to 60 days. Dextrochloropheniramine and ketoprofen were the adjuvant drugs. Multiple symptoms were observed in 90.9 per cent of patients. Intracranial hypertension was manifested in 90.9 per cent. Hydrocephaly occurred in 86.4 per cent. Evolution was satisfactory in 10 patients, 8 died and 4 had sequelae. Tomographic studies showed the appearance of an isolated IVth ventricle in 9 patients, after ventriculoperitoneal shunt, before ABZ treatment in 3 of them, during in 5 and after treatment in one. Median clinical follow-up duration was 10 months for the patients who died and 3-4 years for survivors. In 3 patients there was an increase in cyst size during the administration of the 15 mg/kg/day ABZ dose, which was not observed in any patient when the 30 mg/kg/day dose was used.

Humanos , Masculino , Feminino , História Antiga , Adolescente , Adulto , Pessoa de Meia-Idade , Albendazol/uso terapêutico , Cisticercose/tratamento farmacológico , Doenças do Sistema Nervoso Central/parasitologia , Cetoprofeno/uso terapêutico , Feniramina/uso terapêutico , Acetazolamida/uso terapêutico , Albendazol/administração & dosagem , Cisticercose/líquido cefalorraquidiano , Cisticercose/diagnóstico , Cisticercose/cirurgia , Doenças do Sistema Nervoso Central/diagnóstico , Doenças do Sistema Nervoso Central/tratamento farmacológico , Prognóstico , Tomografia Computadorizada por Raios X