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1.
Psychol. neurosci. (Impr.) ; 5(1): 105-112, Jan.-June 2012. graf, tab
Artigo em Inglês | LILACS | ID: lil-654436

RESUMO

Grooming behavior has been reported to be a response to novelty and other stressors. However, studies that sought to identify anxiety-related measures in the elevated plus-maze have not found grooming as a reliable index. Grooming has been implied with dearousal after a stressful experience. In the present work, a detailed investigation of this behavior was performed in a test with a longer duration (i.e., 10 min) than the usual duration in the elevated plus-maze. The level of anxiety was manipulated prior to the test by confining male rats to environments known to differ in the degree of aversive stimulation, including a familiar cage, a closed arm of the elevated plus-maze, and an open arm (i.e., the most aversive arm) of the elevated plus-maze. Grooming behavior was classified into three constituent elements: rostral grooming, head grooming, and body grooming. The groups were compared with regard to conventional measures of the elevated plus-maze and grooming behavior. Prior confinement to an open arm led to a delayed effect of decreased open-arm exploration undetectable during the first half of the test compared with rats previously confined to a closed arm. Prior confinement to an open arm also increased the total duration of grooming during the second half of the test. These increases were found to be partially attributable to increases in the rostral element of grooming. The percentage of interrupted bouts was also found to discriminate the group previously confined to an open arm. These results indicate that prolongation of the session can reveal effects that are otherwise undetectable and that under such conditions some grooming measures can be useful in the evaluation of anxiety-like behavior.


Assuntos
Animais , Masculino , Ratos , Ansiedade , Comportamento Animal , Asseio Animal , Aprendizagem em Labirinto
2.
Arq. bras. med. vet. zootec ; 60(3): 749-754, jun. 2008. ilus, graf, tab
Artigo em Inglês | LILACS | ID: lil-487924

RESUMO

This study was carried out throughout a laying period to compare the behaviour and performance of two groups of commercial layers, 180 ISA Brown and 120 Hy line W98, housed at 17 weeks of age in furnished cages with a nest box, perches, dust-bath, and claw shortening device. Based on productive parameters, the model of furnished cages studied is suitable for both, Isa Brown and Hy line hens. The study suggested that strain has a significant effect on feather condition and on some behavioural displays, particularly those related to the use of a dust-bath.


Durante um ciclo completo de postura foram avaliados o comportamento e o desempenho de duas linhagens de poedeiras comerciais, 180 ISA Brown e 120 Hy line W98, alojadas com 17 semanas de idade em gaiolas enriquecidas com ninho, poleiros, banho de areia e dispositivos de desgaste de unhas. Em ambas as linhagens, Isa Brown e Hy line W98, o modelo de gaiola estudado foi apropriado em termos de desempenho produtivo. O estudo sugeriu que a linhagem teve efeito significativo sobre a condição da plumagem e sobre alguns aspectos comportamentais, particularmente, aqueles relacionados ao uso do banho de areia.


Assuntos
Animais , Comportamento Animal , Galinhas , Asseio Animal , Areia
3.
Braz. j. med. biol. res ; 41(2): 135-140, Feb. 2008. ilus
Artigo em Inglês | LILACS | ID: lil-474758

RESUMO

The goal of the present study was to investigate the role of thigmotaxis (the tendency to remain close to vertical surfaces) in rat exploratory behavior in an open-field. Thigmotaxis was investigated in a parametric way, using 24 experimentally adult naive male Wistar rats (210-230 g). Exploratory behavior was studied in an open-field (N = 12) in 5-min sessions and behavior was analyzed in terms of where it occurred: in areas surrounded by two, one, or no walls. Another group of rats (N = 12) was studied in an open-field with blocks placed near two of the corners so as to make these corner areas surrounded by three walls. The floor of the open-fields was divided into 20-cm squares in order to locate the exact place of occurrence of each behavior. The following behaviors were recorded: entries into the squares, rearings, and groomings. In both types of open-field the rats chose to remain longer in the squares surrounded by the largest possible number of walls. In one of the open-fields, the mean time (seconds) spent in squares surrounded by two walls was longer than the time spent in squares surrounded by one or no walls (37.2, 7.7, and 1.8 s, respectively). In the other open-field, the mean time spent in squares surrounded by three walls was longer than the time spent in squares surrounded by two, one or no walls (41.7, 20.4, 7.0, and 2.6 s, respectively). Other measures presented a similar profile. These results indicate that rats are sensitive to the number of walls in an environment and prefer to remain close to them.


Assuntos
Animais , Masculino , Ratos , Comportamento Animal/fisiologia , Comportamento Exploratório/fisiologia , Atividade Motora/fisiologia , Asseio Animal/fisiologia , Ratos Wistar , Fatores de Tempo
4.
Invest. clín ; 48(4): 495-508, dic. 2007. tab, graf
Artigo em Espanhol | LILACS | ID: lil-486586

RESUMO

Los modelos animales de aproximación-evitación son útiles para el estudio inicial de drogas con efecto sobre la ansiedad pero los componentes de la ansiedad valorados por estos modelos continúan pobremente definidos. Los modelos complejos de evaluación permiten inferencias más completas que aquellos que evalúan sólo una conducta. Estudios previos demuestran que el antidepresivo tricíclico desipramina ejerce un selectivo efecto anticonflicto sobre ratas adultas sometidas a un programa de privación proteica en edad perinatal, en parámetros de conducta espontánea (laberinto en cruz elevado) e ingesta condicionada (Geller-Seifter). Dichas ratas hiponutridas muestran alteraciones en la neurotransmisión noradrenérgica que se asemejan a la activación generalizada del sistema noradrenérgico que presentan los pacientes que sufren ataques de pánico. Se evaluó la actividad anticonflicto de la desipramina en una prueba de conflicto etológico: el test de bebida en campo abierto, sin descartar a priori ninguna conducta, bajo un enfoque multivariado. Este enfoque no ha sido considerado en estudios previos de campo abierto y drogas antipánico. Sobre cuatro variables seleccionadas por análisis factorial, la administración de desipramina a una dosis de 10mg/kg por sólo 7 días produjo una significativa interacción dieta × droga, consistente con estudios previos. La interacción fue independiente de los efectos de ambos tratamientos sobre el peso o la ingesta y se expresó, en las ratas hiponutridas, como un decremento en todas las conductas excepto en el tiempo de bebida con respecto a las ratas controles que mostraron, en general, un decremento en todas las conductas excepto en la frecuencia de acicalamiento.


Assuntos
Animais , Ratos , Antidepressivos , Ansiedade , Desipramina , Asseio Animal , Argentina , Medicina
5.
Genet. mol. res. (Online) ; 4(1): 105-114, Mar. 2005.
Artigo em Inglês | LILACS | ID: lil-417403

RESUMO

Most research on hygienic behavior has recorded the time taken by the colony to remove an experimental amount of dead brood, usually after one or two days. We evaluated the time that hygienic (H) and non-hygienic (NH) honey bees take to uncap and remove dead brood in observation hives after the brood was killed using the pin-killing assay. Four experimental colonies were selected as the extreme cases among 108 original colonies. Thirty brood cells were perforated with a pin in two H and two NH colonies and observations were made after 1, 2, 3, 4, 5, 6, and 24 h. Different stages of uncapping and removing were recorded. Differences in uncapping and removal between H and NH colonies were significant for all comparisons made at the different times after perforation. Using observation hives one obtains a better and faster discrimination between H and NH colonies than in full size colonies. It is possible to differentiate H and NH within a few hours after perforating the cells


Assuntos
Animais , Abelhas/fisiologia , Comportamento Social , Comportamento Apetitivo , Asseio Animal , Higiene , Odorantes , Fatores de Tempo
6.
Braz. j. med. biol. res ; 35(3): 391-394, Mar. 2002. ilus
Artigo em Inglês | LILACS | ID: lil-304666

RESUMO

The pregnancy-induced increase in self-licking observed in rats is important for mammary gland development and lactation. Reproductive experience has epidemiologial implications such as a decrease in the incidence of mammary gland cancer in women and it also influences various behavioral, neurochemical and endocrine parameters. The aim of the present study was to investigate the influence of reproductive experience on grooming behavior patterns during pregnancy in rats. Self-grooming behavior was measured in age-matched virgin, primi- and multigravid (days 7, 8, 9, 19, and 20 of pregnancy) rats. General grooming (head, forelimbs and shoulders) was not significantly different among virgin, primi- and multigravid rats during pregnancy. Confirming previous work, pregnant rats spent significantly more time in specific grooming (mammary glands, nipple lines, genital and pelvic regions) than did virgin animals. In addition, self- licking of mammary glands was significantly increased in multi- as compared to primigravid rats on days 8, 9, 19 and 20 of pregnancy. The increase in mammary gland grooming observed in multigravid rats appears to be a consequence of previous reproductive experience. These data show that reproductive experience modulates mammary gland grooming during pregnancy, possibly contributing to successful reproduction


Assuntos
Animais , Feminino , Gravidez , Ratos , Asseio Animal , Prenhez , Comportamento Sexual Animal , Análise de Variância , Mama , Lactação , Ratos Wistar
7.
Braz. j. med. biol. res ; 34(11): 1465-1470, Nov. 2001. ilus, tab
Artigo em Inglês | LILACS | ID: lil-303322

RESUMO

Dopamine receptors are involved in the expression of grooming behavior. The pregnancy-induced increase in self-licking observed in rats is important for mammary gland development and lactation. This study focuses on the role of dopamine receptor subtypes in grooming behavior of virgin and pregnant female rats. General and mammary gland grooming were measured in virgin rats treated with 0.25 mg/kg of the D1-like agonist SKF-81297 and antagonist SKF-83566 and the D2-like agonist lisuride and antagonist sulpiride. The effects of 0.01 and 0.25 mg/kg doses of the same agonists and antagonists were evaluated in pregnant rats as well. In virgin animals both SKF-83566 and sulpiride treatments significantly reduced the time spent in general grooming, while none of the dopamine agonists was able to significantly change any parameter of general grooming. Time spent in grooming directed at the mammary glands was not affected significantly by any of the drug treatments in virgin rats. All drugs tested significantly decreased the frequency of and the time spent with general grooming, while SKF-81297 treatment alone did not significantly reduce the duration of mammary gland grooming in pregnant rats. These data show that in female rats the behavioral effects of D1-like and D2-like dopamine receptor stimulation and blockade differ according to physiological state. The results suggest that dopamine receptors may play specific roles modulating grooming behavior in pregnant rats. Since grooming of the mammary gland during pregnancy may influence lactation, this aspect is relevant for studies regarding the perinatal use of dopamine-related drugs


Assuntos
Animais , Feminino , Gravidez , Ratos , Agonistas de Dopamina , Antagonistas de Dopamina , Asseio Animal , Benzazepinas , Lisurida , Glândulas Mamárias Animais , Ratos Wistar
8.
Säo Paulo; s.n; 1999. 153 p. tab, graf.
Tese em Português | LILACS | ID: lil-258749

RESUMO

Para descrever a distribuiçäo temporal diária das interaçöes de cataçäo e da autocataçäo do par reprodutor em sagüis-do-nordeste (Callithrix jacchus) ao longo do ciclo reprodutivo, dois grupos familiares foram observados no núcleo de primatologia da UFRN (Natal, RN 05§46'S 35§12'W), sob condiçöes de temperatura, iluminaçäo e umidade naturais através do método focal contínuo durante toda a fase ativa. As observaçöes comportamentais foram realizadas em dois grupos de animais. No primeiro durante duas gestaçöes e dois pós-partos näo consecutivos e no segundo ao longo do intervalo entre duas gestaçöes sucessivas, uma gestaçäo e pós-parto das fêmeas reprodutoras. A condiçäo reprodutiva das fêmeas reprodutoras e näo-reprodutoras de cada grupo foi caracterizada através da monitorizaçäo dos níveis fecais de progesterona, pelo método Elisa. Foram encontrados períodos de 24 e 8h na duraçäo da autocataçäo e das interaçöes de cataçäo social entre o par reprodutor e cada membro do grupo familiar (Cosinor, p menor ou igual 0,05). Entretanto, a periodicidade de 24h näo se apresentou estatisticamente significativa na autocataçäo e em algumas interaçöes, diante de mudanças da condiçäo reprodutiva da fêmea, associadas com a presença dos filhotes recém-nascidos após o parto e com o aumento do tamanho do grupo durante o estudo. O desaparecimento desta periodicidade após o parto pode estar relacionada a um efeito modulador do cuidado à prole recém-nascida. O par reprodutor mostrou interaçöes recorrentes com periodicidade circadiana com possíveis parceiros preferenciais, ou seja com o parceiro reprodutor e no caso do macho reprodutor, com outros filhotes machos presentes no grupo. Por outro lado, a fêmea reprodutora de um dos grupos näo mostrou esta periodicidade na cataçäo feita na fêmea adulta näo-reprodutora, quando esta passou a apresentar ciclos ovarianos. As acrofases para o período de 24h concentram-se durante a manhä, mostrando diferenças irregulares nos intervalos de confiança em algumas fases, näo permitindo identificar horários preferenciais para a interaçäo com animais específicos. Na duraçäo total diária da cataçäo feita, o par reprodutor teve preferência pelo parceiro reprodutivo, embora a fêmea apresentasse preferência pela autocataçäo ou por outros parceiros em algumas fases. A comparaçäo da autocataçäo e da cataçäo feita e recebida por cada animal em totais diários e por hora (teste Kruskall-Wallis, p menor ou igual 0,05) mostrou resultados...


Assuntos
Animais , Comportamento Animal , Callithrix , Ritmo Circadiano , Asseio Animal , Progesterona , Estatísticas não Paramétricas
9.
Parasitol. día ; 20(3/4): 147-9, jul.-dic. 1996.
Artigo em Português | LILACS | ID: lil-202478

RESUMO

De quarenta examplares de ectoparasitos colhidos de uma preguica (Bradypus variegatus) cativa na Fundacao Rio-Zoo, procedeu-se a identificacao do material. Os ectoparasitos semelhantes a pequena mariposa, removidos de entre a pelagem e crostas da pele, foram trabalhados entre dezembro/93 e outubro/94. Procedeu-se a investigacao bibliográfica com base na literatura do Museu Nacional do Rio de Janeiro e do Laboratório de Morfofisiologia e Patogenia de Carrapatos-Sanidade Animal (LMPC/SA) do Departamento de Parasitologia Animal do Instituto de Biologia da Universidade Federal Rural do Rio de Janeiro (DPA/IB/UFRRJ). Para a análise das característic desses lepidópteros foi necessário o processamento para a descamacao das asas, que permitisse a identificacao a nivel de genero e espécie. A metodologia utilizada para tanto foi desenvolvida especificamente para este Colecao Entomológica do Instituto Oswaldo Cruz sob o número PIR-001. Todo este estudo enquadra-se no projeto interinstitucional envolvendo a Fundacao Jardim Zoológico do Rio de Janeiro e a Universidade Federal Rural do Rio de Janeiro, representada pelo LMPC-SA/DPA/IB


Assuntos
Humanos , Psychodidae/anatomia & histologia , Bichos-Preguiça/parasitologia , Brasil , Ectoparasitoses/parasitologia , Asseio Animal/fisiologia , Larva/anatomia & histologia , Larva/parasitologia , Interações Hospedeiro-Parasita
10.
Braz. j. med. biol. res ; 29(6): 805-10, jun. 1996. ilus, tab
Artigo em Inglês | LILACS | ID: lil-181416

RESUMO

The effect of unilateral injection of peptides into the nucleus accumbens septi (NAS) on subcategories of grooming behavior was studied in male rats. The peptides used were: thyrotropin releasing hormone (TRH), luteinizing hormone releasing hormone (LHRH) and corticotropin releasing hormone (CRH). Male rats (Holtzman strain, 240-270 g body weight) injected with progressive doses of TRH (100, 200 and 400 ng) at 5-day intervals were compared with the control state (injection of artificial cerebrospinal fluid CSF). A selective increase in face grooming was observed with the 100 ng (49.78 + 6.11, N = 18) and 200 ng (50.29 + 7.72, N = 17) doses of TRH (P<0.05 vs CSF injection 26.94 + 3.64, N = 18). Face grooming increased further with the 400 ng dose (55.19 + 8.26, N = 16, P<0.01), but a dose-response curve could not be obtained at the dose range used. Flank scratching, head, body and genital grooming were not altered by the TRH injection, but the rearing behavior was inhibited (10.33 + 1.56; N = 18; 10.76 + 1.77, N = 17; 12 + 2.06, N = 16) (P<0.05 for all doses vs controls, 20.61 + 2.81, N = 18). The rats that received LHRH (75 ng, N = 16) and CRH (100 ng, N = 14) did not show behavioral changes when compared with their control states. The results show that injection on TRH into the NAS, but not the injection of LHRH or CRH, selectively increases face grooming without affecting other subcategories of grooming at the doses used, and appears to link this peptide with the neural substrate of stereotyped behavior.


Assuntos
Animais , Masculino , Ratos , Comportamento Animal/efeitos dos fármacos , Líquido Cefalorraquidiano , Hormônio Liberador de Gonadotropina/farmacologia , Asseio Animal/efeitos dos fármacos , Hormônio Liberador da Corticotropina/farmacologia , Núcleo Accumbens/metabolismo , Hormônio Liberador de Tireotropina/farmacologia , Relação Dose-Resposta a Droga , Face , Injeções , Ratos Sprague-Dawley
11.
Braz. j. med. biol. res ; 29(3): 375-9, Mar. 1996. graf
Artigo em Inglês | LILACS | ID: lil-163847

RESUMO

This paper reports the effects on grooming, related behaviors and levels of anxiety induced by the hypophysiotropic peptides corticotropin-releasing hormone (CRH, 1 mug, 0.2 nmol, icv), thyrotropin-releasing hormone (TRH, 100 mug, 275 nmol, icv) and luteinizing hormone-releasing hormone (LHRH, 1.5 mug, 1.3 nmol, icv) administered into the lateral ventricle of the brain (icv) of adult male rats of a Holtzman-derived colony (N = 15, each group). CRH induced an increase in total grooming scores, whereas LHRH, TRH and vehicle had no effect. CRH strongly increased face and head grooming and induced head shakes. The time spent in rearing and gnawing was significantly decreased. In the plus-maze, CRH reduced the time of exploration in the open arm. TRH increased face grooming and induced body shakes. LHRH had no effect on grooming or rearing behavior. No body or head shakes were observed after LHRH administration. Scoring of individual grooming elements demonstrated differences in action of the three peptides. Although both CRH and TRH increased face grooming, only CRH induced head grooming. Furthermore, CRH induced predominantly head shakes while TRH increased body shake activity. In contrast, CRH was anxiogenic and TRH appeared to induce stereotyped behavior. From the characterization of grooming elements and related responses, we conclude that each hypophysiotropic peptide induces a specific behavioral pattern.


Assuntos
Animais , Masculino , Ratos , Ansiedade/induzido quimicamente , Hormônio Liberador de Gonadotropina/farmacologia , Asseio Animal/efeitos dos fármacos , Hormônio Liberador da Corticotropina/farmacologia , Hormônio Liberador de Tireotropina/farmacologia , Hormônio Liberador de Gonadotropina/administração & dosagem , Hormônio Liberador da Corticotropina/administração & dosagem , Injeções Intraventriculares , Ratos Sprague-Dawley , Hormônio Liberador de Tireotropina/administração & dosagem
12.
Braz. j. med. biol. res ; 27(1): 61-5, jan. 1994. tab, ilus
Artigo em Inglês | LILACS | ID: lil-136493

RESUMO

Grooming is an important social activity among primates. In an investigation of its diurnal distribution, all grooming episodes (self-and allo-) were recorded in three families of captive common marmosets (Callithrix jacchus) kept under natural environmental conditions at hourly intervals for periods of 20 min from 05:00 to 18:00 h, for three consecutive days a week for four weeks. The three families were composed of a reproductive pair and their offspring, with 8, 8 and 7 individuals, respectively. No significant variations were detected within families in terms of days or weeks. However, one family did perform more grooming than the others. The frequency of grooming episodes per hour/per family was higher during the period from 08:00-12:00 h, with acrophases narrowly distributed near 10:00 h, (Family 1 = 10:32 ñ 00:33 h; Family 2 = 10:11 ñ 00:13 h; Family 3 = 09:45 ñ 00:14 h) and lower frequencies were observed at the beginning and end of the active period. The differences between families are probably related to the social dynamics of the individual groups and not to their size


Assuntos
Animais , Masculino , Feminino , Comportamento Animal , Callithrix/anatomia & histologia , Ritmo Circadiano , Asseio Animal , Especificidade da Espécie , Atividade Motora , Primatas/anatomia & histologia , Fatores de Tempo
13.
Braz. j. med. biol. res ; 24(5): 509-13, 1991. tab
Artigo em Inglês | LILACS | ID: lil-99483

RESUMO

The effect of massive lesions of the telencephalon on the repertoire of captive pigeons were investigated. The behavior of four birds with an intact telencephalon was compared to that of four birds submitted to ablation of telencephalic structures. Behavioral audio recording was done according to previously defined categories in three daily sessions for fifteen days. Experimental birds were followed up for month. Immediately after the lesion, operated birds showed decreases in the occurrence of different behaviors such as coording movements, feeding, interaction, preening, maintenance, exploration and vocalization and increases in locomotion and discrete movements of the body when compared to the control birds (P<0.05). Recovery of exploration (P<0.05), feeding and localization was during the follow-up period. These data are interpreted as suggestive of a functional role of the telencephalon in the organization of behavior and a long-term recovery of behavior after detelencephalation


Assuntos
Animais , Comportamento Animal/fisiologia , Columbidae/fisiologia , Telencéfalo/fisiologia , Comportamento Exploratório/fisiologia , Comportamento Alimentar/fisiologia , Asseio Animal/fisiologia , Locomoção/fisiologia , Movimento/fisiologia , Plasticidade Neuronal/fisiologia , Vocalização Animal/fisiologia
14.
Braz. j. med. biol. res ; 23(11): 1133-7, 1990. ilus
Artigo em Português | LILACS | ID: lil-91614

RESUMO

The behavioral effects of intravrnticular 1-micronl injections of adrenaline and noradrenaline (both in a concentration of 30 nmol/micronl) were wxamined in pigeons bearing cannule chronically implanted into the lateral ventricles. Injections of either catcholoamine evoked immediate and intense bouts of feeding behavior, followed by long-lasting incrases in sleep duration (50-90% higher than vehicle-treated subjects) in pigeons given free access to food during the observation period. Pigeons treated with adrenaline or vehicle only, and placed in a cage without the feeder set (food-deprived durngi the observation period), exhibited late increases in exploratory and preening behaviors, and less sleep than controls (vehicle-treated pigeons with free access to food). These data suggest that post-prandial sleep in this situation may represent a by-product of feeding-related processes evoked by both catecholamines


Assuntos
Animais , Masculino , Feminino , Comportamento Animal/efeitos dos fármacos , Epinefrina/fisiologia , Norepinefrina/fisiologia , Columbidae , Comportamento Exploratório , Comportamento Alimentar , Epinefrina/administração & dosagem , Asseio Animal/efeitos dos fármacos , Injeções Intraventriculares , Norepinefrina/administração & dosagem , Veículos Farmacêuticos/administração & dosagem , Sono/efeitos dos fármacos
15.
Bol. estud. méd. biol ; 37(1/2): 3-10, ene.-jul. 1989. tab
Artigo em Inglês | LILACS | ID: lil-88609

RESUMO

Se estudió el efecto provocado por la administración neonatal de tiroxina (1 ug/gr de peso corporal por vía intraperitoneal, en los días 1 al 3 postparto), sobre el desarrollo de seis componentes de la conducta de auto aseo en ratas Wistar macho entre los días 1 y 60 postparto. Los resultados mostraron que la administración neonatal de la hormona provocó una aceleración de 2 a 3 días en la aparición de componentes del aseo. Paralelamente no se modificó importantemente el desarrollo de quellos componentes dirigidos a partes limitadas del cuerpo como son el lamido de las manos, de la cara y de la cabeza. Por el contrario, se observó un incremento significativo de aquellos componentes dirigidos a porciones amplias del cuerpo, como el lamido de la piel y de la región anogenital, así como el rascado con las extremidades posteriores. Los hallazgos sugieren que el tratamiento hormonal temprano, pudiera interferir con el desarrollo de los circuitos neuronales que participan en la modulación de los movimientos del auto aseo dirigido a zonas más amplias del cuerpo


Assuntos
Recém-Nascido , Lactente , Ratos , Masculino , Comportamento Animal/efeitos dos fármacos , Asseio Animal/efeitos dos fármacos , Hormônios/administração & dosagem , Atividade Motora/efeitos dos fármacos , Neonatologia , Tiroxina/efeitos adversos
16.
Acta physiol. pharmacol. latinoam ; 39(1): 49-56, 1989. ilus, tab
Artigo em Inglês | LILACS | ID: lil-76852

RESUMO

Cuando alfa-MSH es inyectado en el área tegmental ventral (VTA) o intracerebroventricularmente (icv) induce comportamiento de aseo excesivo. La infusión icv del péptido tamién provoca el síndrome de estiramiento y bostezo (SEB). Estos efectos son suprimidos por la administración de atropina intraperitoneal, icv o en el ATV. Las evidencias experimentales presentadas sugerían que alfa-MSH actuaría específicamente sobre una aferencia colinérgica en el ATV. Los resultados indicarían que el péptido actuaría en un blanco neural distinto al sistema dopaminérgico , y originaría los cambios comportamentales recientemente mencionados


Assuntos
Ratos , Animais , Masculino , alfa-MSH/administração & dosagem , alfa-MSH/antagonistas & inibidores , alfa-MSH/farmacologia , Atropina/farmacologia , Encéfalo/patologia , Asseio Animal/efeitos dos fármacos , Injeções Intraventriculares , Mecamilamina/farmacologia , Atividade Motora/efeitos dos fármacos
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