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1.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 38(4): 431-437, 2020 Aug 01.
Artigo em Chinês | MEDLINE | ID: mdl-32865364

RESUMO

Oral cancer is the most common malignant tumor in the head and neck, and is one of the world's top ten malignancies. Microbial infection is an important risk factor of oral cancer. Candida albicans is the most popular opportunistic fungal pathogen. Epidemiological studies have shown that Candida albicans is closely tied to oral malignancy. Animal experimentation have also proven that infection of Candida albicans can promote the development of oral epithelial carcinogenesis. The current studies have revealed several mechanisms involved in this process, including destroying the epithelial barrier, producing carcinogenic substances (nitrosamines, acetaldehyde), inducing chronic inflammation, activating immune response, etc. However, current researches on mechanisms are still inadequate, and some hypotheses remain controversial. Here, we review the findings related to Candida albicans' effect on the malignant transformation of oral mucosa, hoping to provide reference for deep research and controlling oral cancer clinically.


Assuntos
Doenças da Boca , Neoplasias Bucais , Animais , Candida albicans , Carcinogênese , Mucosa Bucal
2.
Gerodontology ; 37(3): 307-311, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32809252

RESUMO

INTRODUCTION: Lymphomas are a heterogeneous group of malignant neoplasms of lymphocytes and their precursor cells. Lymphoma is seen 3.5% of all intraoral malignancies and is the second most common neoplasm after the squamous cell carcinoma in the head and neck region. Diffuse large B-cell lymphomas (DLBCL), which is a subtype of non-Hodgkin lymphoma, are seen mostly in the paraoral region. CASE PRESENTATION: An 82-year-old woman was referred with a localised swelling of the mandibular buccal mucosa for 3 months. Excisional biopsy revealed the diagnosis of DLBCL in the mandible and chemotherapy regimen started immediately. However, patient died during treatment. CONCLUSIONS: Non-Hodgkin's lymphomas would be late- or misdiagnosed in the perioral region that may result poor prognosis.


Assuntos
Linfoma Difuso de Grandes Células B , Linfoma não Hodgkin , Idoso de 80 Anos ou mais , Biópsia , Feminino , Humanos , Mandíbula , Mucosa Bucal
3.
Ned Tijdschr Tandheelkd ; 127(7-08): 434-440, 2020.
Artigo em Holandês | MEDLINE | ID: mdl-32840499

RESUMO

Many medications prescribed in the Netherlands have adverse effects on the oral mucosa. Adverse events often described are stomatitis, white lesions, abnormal pigmentation and sensibility disorders. Stomatitis is frequently observed in patients using medications for the treatment of malignancies or auto-immune diseases. Important causative classes of medicines are alkylating agents, anthracyclines, monoclonal antibodies, protein kinase inhibitors, purine derivatives, pyrimidine antagonists, taxanes and vinca alkaloids. White oral lesions often concern candidiasis and are frequently seen in patients using certain immunosuppressants and antibiotics. Abnormal pigmentation is frequently seen in patients using hydroxycarbamide, an antineoplastic agent. Sensibility disorders of the oral mucosa are described in several classes of medications, including protein kinase inhibitors. It is very important oral healthcare professionals can recognise possible adverse effects of medications on the oral mucosa. When it is probable an anomaly of the oral mucosa is caused by medication, the oral healthcare professional should contact the prescribing physician to discuss the possibility of adjusting or discontinuing the medication.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Úlceras Orais , Humanos , Mucosa Bucal , Países Baixos
4.
J Med Life ; 13(2): 164-169, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32742508

RESUMO

Behçet's disease is a systemic vasculitis. Mucocutaneous involvement is the most prominent finding, but triggering factors are not well-known. We decided to assess the beliefs of patients with Behçet's disease regarding the potential role of food, mucosal injury, menstruation, and stress in the appearance of symptoms. In this cross-sectional study, 60 patients with Behçet's disease who fulfilled the International Study Group criteria for Behçet's disease and referred to the outpatient Behçet's clinic of Motahari, affiliated to Shiraz University of Medical Sciences, were included. A questionnaire was designed by the research team consisting of the rheumatologist involved in the study, two dietitians, and a psychiatrist. The patients were interviewed face-to-face to fill in the questionnaire. The assessed variables were all food categories, menstruation, psychological stress, and oral mucosal injury as the potential triggers of symptoms onset. The most common foods reported as triggers for oral ulcers were eggplant (78.3%), melon (68.3%), walnut (68.2%), and cantaloupe (66.7%). Walnut was reported by three patients (5%) as the most common trigger for genital ulcers. Nervous tension (83%) and annoying arguments (45%) were the two most common psychological stress triggers for oral ulcers. Seven patients (11.7%) reported tooth brushing, as the trigger for oral ulcers. The irregular menstrual cycle was a trigger for oral ulcers in only two patients. Food items such as eggplant, walnut and melon were common self-reported triggers for mucocutaneous lesions in patients with Behçet's disease. Nervous tension and annoying arguments were also common psychological triggers for oral aphthous ulcers.


Assuntos
Síndrome de Behçet/psicologia , Cultura , Alimentos , Menstruação/psicologia , Mucosa Bucal/patologia , Estresse Psicológico/complicações , Adulto , Síndrome de Behçet/diagnóstico , Estudos Transversais , Feminino , Humanos , Masculino , Úlceras Orais/complicações , Úlceras Orais/psicologia , Dor/etiologia , Recidiva
5.
Int J Oral Sci ; 12(1): 23, 2020 08 21.
Artigo em Inglês | MEDLINE | ID: mdl-32826859

RESUMO

The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, ß1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.


Assuntos
Carcinoma de Células Escamosas/patologia , Transformação Celular Neoplásica/patologia , Neoplasias Bucais/patologia , Fibrose Oral Submucosa/patologia , Animais , Camundongos , Mucosa Bucal , Células-Tronco
6.
Mymensingh Med J ; 29(3): 516-522, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32844788

RESUMO

The surgical procedures of post traumatic posterior urethral stricture and distraction defects range from the extremely simple to the extremely radical. In oral Mucosal Graft Augmented Anastomotic Urethroplasty (OMG AAU) the stricture segment is excised followed by partially re-anastomosis of the dorsal or ventral urethral wall then the reconstruction is completed by placement of oral mucosal graft into the remaining urethral defect. The aim of this study is to determine the impact and assess the effectiveness of this technique, discuss the procedure and outcome and to refine them where found lacking. A prospectively collected review of records was done from September 2010 to April 2019. A total 100 patients with post traumatic urethral stricture and distraction defect were treated by dorsal onlay oral mucosal graft augmented anastomotic urethroplasty by same surgeon in a single centre. All were followed up every 3 and 6 monthly for 1-2 years with uroflowmetry. Retrograde urethrogram/Micturating cysto-urethrogram (RGU/MCU) and cystoscopy were reserved for those who had complained of obstructive symptoms and uroflowmetry evidence of outflow obstruction. The etiology of trauma was road traffic accident (RTA) (69%), falling astride (28%) and traumatic catheterization (3%). Mean excised stricture length was 1.5cm (Range 1.0-2.2). The mean length of dorsal onlay considering excised stricture length and 1cm spatulations was 4.25cm (range 2.0-6.5). The successful recovery was observed in 94% cases. On conclusion the technique of OMG AAU is very easy to do, reliable and has high success rates. This is also the procedure of choice for long segment obliterative strictures. For post traumatic obliterative strictures and distraction defects we strongly recommend the procedure for successful and patient satisfactory outcome.


Assuntos
Procedimentos Cirúrgicos Reconstrutivos , Estreitamento Uretral/cirurgia , Humanos , Masculino , Mucosa Bucal , Estudos Retrospectivos , Resultado do Tratamento , Uretra/cirurgia , Procedimentos Cirúrgicos Urológicos Masculinos
7.
Int J Mol Sci ; 21(17)2020 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-32825469

RESUMO

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and furin, which promote entry of the virus into the host cell, have been identified as determinants of SARS-CoV-2 infection. Dorsal tongue and gingiva, saliva, and tongue coating samples were examined to determine the presence of these molecules in the oral cavity. Immunohistochemical analyses showed that ACE2 was expressed in the stratified squamous epithelium of the dorsal tongue and gingiva. TMPRSS2 was strongly expressed in stratified squamous epithelium in the keratinized surface layer and detected in the saliva and tongue coating samples via Western blot. Furin was localized mainly in the lower layer of stratified squamous epithelium and detected in the saliva but not tongue coating. ACE2, TMPRSS2, and furin mRNA expression was observed in taste bud-derived cultured cells, which was similar to the immunofluorescence observations. These data showed that essential molecules for SARS-CoV-2 infection were abundant in the oral cavity. However, the database analysis showed that saliva also contains many protease inhibitors. Therefore, although the oral cavity may be the entry route for SARS-CoV-2, other factors including protease inhibitors in the saliva that inhibit viral entry should be considered.


Assuntos
Betacoronavirus/metabolismo , Furina/metabolismo , Mucosa Bucal/metabolismo , Peptidil Dipeptidase A/metabolismo , Serina Endopeptidases/metabolismo , Glicoproteína da Espícula de Coronavírus/metabolismo , Infecções por Coronavirus/metabolismo , Gengiva/metabolismo , Humanos , Pandemias , Pneumonia Viral/metabolismo , Saliva/metabolismo , Língua/metabolismo , Internalização do Vírus
8.
Wiad Lek ; 73(7): 1510-1515, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32759447

RESUMO

OBJECTIVE: The aim: of the study is to compare surgical and functional results as well as quality of life after use of skin flaps - platysma myocutaneus flap, supraclavicular artery flap and fascial flaps - temporoparietal fascial flap, buccal fat pad for plastic closure of the buccal and retromolar trigone mucous surgical defects in cancer patients. PATIENTS AND METHODS: Material and methods: A retrospective comparative analysis of the results of surgical treatment of buccal and retromolar trigone mucosal cancer in 56 patients operated from 2009 to 2014 was made. The patients were divided into two groups: the first included 26 patients, with reconstruction of fascial flaps, the second group included 30 patients, with reconstruction of postoperative defects with skin flaps. Surgical results: the average duration of surgery, the average duration of inpatient treatment and the presence of complications were compared in the both groups. Functional results in both groups were compared in 6 and 12 months after surgery with the Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), and quality of life was assessed by the University of Washington Quality of Life questionnaire, version 4. RESULTS: Results: Average duration of surgery, average time of inpatient treatment, and postoperative complications did not differ significantly in both groups (P> 0.05). Data of performance status and quality of life in patients with reconstruction of mucosal defects and retromolar trigone with skin flaps were significantly better (P> 0.05) in 6 and 12 months after surgery, compared with the group of patients who underwent defect reconstruction with fascial flaps. CONCLUSION: Conclusions: The method of choice in reconstruction of medium and large defects of the buccal and the retromolar trigone mucous is usage of skin flaps: the platysma myocutaneus flap and the flap of the supraclavicular artery.


Assuntos
Qualidade de Vida , Procedimentos Cirúrgicos Reconstrutivos , Humanos , Boca , Mucosa Bucal , Estudos Retrospectivos , Retalhos Cirúrgicos
9.
Environ Sci Pollut Res Int ; 27(30): 37920-37926, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32617811

RESUMO

The objective of this study was to analyze and compare the presence of argyrophilic nucleolar organizer regions (AgNORs) in exfoliated cells obtained from the buccal mucosa among crack and cocaine users and non-users by the AgNOR staining technique. Seventy-three males ≥ 18 years were categorized into two groups: 38 crack and/or cocaine users and 35 non-user volunteers. They were interviewed and responded a questionnaire regarding general health and drug addiction. Exfoliative cytology specimens were collected from the clinically intact buccal mucosa, and cytological preparations were fixed and stained by AgNOR technique. The mean number of AgNORs (p = 0.02) and the percentage of epithelial cells with more than 3 (p = 0.01) and 4 (p = 0.04) AgNORs/nucleus were significantly higher in the non-user group. In conclusion, the frequency and diversity of substances present in the drugs-cocaine, crack, and alcohol-consumed by the volunteers of this study may have influenced the number of AgNORs and the response to damage and consequent effect on protein synthesis.


Assuntos
Cocaína , Mucosa Bucal , Estudos Transversais , Humanos , Masculino , Região Organizadora do Nucléolo , Coloração pela Prata
10.
Int J Nanomedicine ; 15: 4001-4020, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32606661

RESUMO

Background: Simvastatin (SMV), a hypocholesterolemic agent, suffers from very low bioavailability due to its poor aqueous solubility and extensive first-pass metabolism. Methods: Two SMV carrier systems, namely, polymeric drug inclusion complex (IC) and mixed micelles (MM) nanoparticles, were developed and loaded into mucoadhesive buccal films to enhance SMV bioavailability. The two carrier systems were characterized and their permeation across human oral epithelial cells (OEC) was studied. The effect of IC to MM ratio (X1) and the mucoadhesive polymer concentration (X2) on the cumulative percent of drug released, elongation percent and the mucoadhesive strength, from the prepared mucoadhesive films, were optimized. Ex vivo permeation across bovine mucosal tissue was investigated. The permeation parameters for the in vitro and ex vivo release data were calculated. Results: Complexation of SMV with hydroxypropyl beta-cyclodextrin (HP ß-CD) was superior to all other polymers as revealed by the equilibrium saturation solubility, stability constant, complexation efficiency and thermodynamic potential. SMV-HP ß-CD IC was utilized to develop a saturated polymeric drug solution. Both carrier systems showed enhanced permeation across OEC when compared to pure drug. X1 and X2 were significantly affecting the characteristics of the prepared films. The optimized mucoadhesive buccal film formulation loaded with SMV IC and drug MM nanoparticles demonstrated superior ex vivo permeation when compared to the corresponding pure drug buccal film, and the calculated permeation parameters confirmed this finding. Conclusion: Mucoadhesive buccal films containing SMV IC and drug MM can be used to improve drug bioavailability; however, additional pharmacokinetic and pharmacodynamic studies are required.


Assuntos
Portadores de Fármacos/química , Liberação Controlada de Fármacos , Mucosa Bucal/efeitos dos fármacos , Muco/química , Sinvastatina/farmacologia , 2-Hidroxipropil-beta-Ciclodextrina/química , Adesividade , Animais , Varredura Diferencial de Calorimetria , Bovinos , Sistemas de Liberação de Medicamentos , Humanos , Nanopartículas/química , Nanopartículas/ultraestrutura , Permeabilidade , Solubilidade , Espectroscopia de Infravermelho com Transformada de Fourier , Difração de Raios X
11.
Braz Dent J ; 31(3): 344-348, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32667521

RESUMO

Caliber persistent labial artery (CPLA) consists in a dilated portion of the main branch of the labial artery without loss of size. The aim of this study is to report a case of a patient diagnosed with CPLA in the upper lip, emphasizing unusual histopathological and immunohistochemical findings. A 67-year-old female patient with complaint of a pulsating upper lip lesion without painful symptomatology. Under a clinical diagnosis of CPLA, and considering that the patient was edentulous and used a total prosthesis, an excisional biopsy of the lesion was performed to avoid future traumas in the region and consequently possible exuberant local bleeding. At anatomopathological examination structures suggestive of lymphoid follicles and germinal centers were visualized. Immunohistochemistry showed positivity for CD20, CD68, desmin and CD34 and negativity for CD4. The patient did not have a history of allergies, cardiovascular, rheumatic or systemic diseases that could justified the findings. The case presents unusual histopathological structures, evidencing the necessity of more studies about this pathology so scarce in the literature.


Assuntos
Doenças Labiais , Malformações Vasculares , Idoso , Artérias , Biópsia , Feminino , Humanos , Lábio , Mucosa Bucal
12.
Braz Dent J ; 31(3): 310-318, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32667525

RESUMO

Oral mucositis is a common inflammatory complication among patients with cancer. This study evaluated the histopathological, stereological, and antioxidant markers of 2% eucalyptus extract in induced oral mucositis in male golden hamsters. In this animal study, oral mucositis was induced in 30 male golden hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle once daily on days 3 and 4. On days 14-17, 2% eucalyptus hydroalcoholic extract gel and Calendula officinalis extract gel groups were treated and then compared with a non-treated control group. The histopathological and stereological scores and the pouch content of malondialdehyde, as well as the activities of glutathione and myeloperoxidase in the pouch tissue, were evaluated. Histopathologic scores of oral mucositis were lower in the eucalyptus gel group than those of the calendula and control groups (p<0.05). Also, a lower malondialdehyde level and higher myeloperoxidase and glutathione activities were detected in the eucalyptus group in comparison to the calendula and control groups (p<0.001). The thickness of the mucosa and submucosa increased in the eucalyptus group. The numerical density of the fibroblast and the volume density of the collagen significantly increased in the eucalyptus group. In conclusion, the use of eucalyptus hydroalcoholic extract may be associated with reduced intensity of oral mucositis, diminished concentration of malondialdehyde, increased activity of myeloperoxidase and glutathione, increased volume of mucosa and submucosa, increased fibroblast and collagen in the induced oral mucositis in golden hamsters undergoing 5-FU consumption.


Assuntos
Eucalyptus , Mucosite , Estomatite , Animais , Cricetinae , Fluoruracila , Masculino , Mesocricetus , Mucosa Bucal , Extratos Vegetais
13.
Quintessence Int ; 51(8): 630-638, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32613209

RESUMO

OBJECTIVES: The aim of the present study was to compare the clinical outcomes after using free gingival grafts (FGGs) and mucosal excision during exposure of submerged orthodontic implants. METHOD AND MATERIALS: Bilateral sites in 28 subjects were divided into two groups: In the FGG group, FGG augmentation was performed around the orthodontic implants, and in the mucosal excision group, a periosteal bed was made after mucosal excision to promote attached mucosa with no additional soft-tissue augmentation. Outcomes measured during the course of the study were the width of attached mucosa, soft tissue regrowth, degree of inflammation, oral debris, and shrinkage of the attached mucosa around the orthodontic implants over a period of 3 months. RESULTS: FGG was more effective in increasing the width of attached mucosa over simple excision of the mucosa alone (2.87 mm vs 1.5 mm; P = .001). In both the groups, there was minimal postoperative soft tissue regrowth over the orthodontic implants, with no statistical significance difference between them (P > .05). The AM in both the treatment modalities demonstrated significant shrinkage (44% in FGG group vs 68% in mucosal excision group; P = .001). However, sites receiving augmentation showed significantly less inflammation than sites treated with mucosal excision (0.63 vs 1.5; P = .001). There was no statistical difference in oral debri accumulation between both the treatment modalities (P = .43) at the end of study period. CONCLUSION: Over a simple mucosal excision, using a FGG results in an uninflamed and immobile band of attached mucosa around an orthodontic implant, which offers greater comfort and stability during its function.


Assuntos
Implantes Dentários , Implantação Dentária Endo-Óssea , Gengiva , Boca , Mucosa Bucal , Membrana Mucosa
14.
Stomatologiia (Mosk) ; 99(3): 18-21, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32608943

RESUMO

The article is devoted to the study of immunohistochemical parameters in patients with bullous lesions of the oral mucosa. The biopsy samples of the oral mucosa were studied in 57 patients, including patients with pemphigoid bullosa (38 people) and pemphigus vulgaris (19 people). The results of immunohistochemical studies indicate the cellular mechanisms of damage to the epithelium, in which IL-1, IL-6 and HPV16 are involved.


Assuntos
Penfigoide Bolhoso , Pênfigo , Vesícula , Humanos , Mucosa Bucal
15.
Stomatologiia (Mosk) ; 99(3): 37-40, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32608947

RESUMO

OBJECTIVE: To study changes in the parameters of endogenous intoxication using the level of substances of low and medium molecular weight in the oral fluid in patients with catarrhal stomatitis, which got developed after the acute drug poisoning. MATERIAL AND METHODS: To determine the degree of intoxication, we studied the concentrations of low and medium molecular weight substances (SLMMW) in the oral fluid of patients. We studied the saliva of 20 patients (13 men and 7 women, average age 39 years). The control was done against the oral fluid of 10 healthy individuals. The studies were conducted in a control group consisting of 10 healthy individuals with intact oral mucosa and two groups of patients (20 patients in total) with drug poisoning. The first of these two groups of patients included 8 individuals without pathological changes in the oral mucosa, while the second group consisted of 12 patients diagnosed with catarrhal stomatitis that developed after acute drug poisoning. RESULTS: It became known that endogenous intoxication develops in the oral fluid of patients with acute drug poisoning, which is manifested by a statistically significant increase in the content of SLMMW in comparison with practically healthy individuals (15.3%). And the total level of SLMMW in the oral fluid of patients with acute drug stomatitis and catarrhal stomatitis has increased by 42.3% relative to the data of practically healthy individuals. CONCLUSION: Studies have shown the need for monitoring the oral cavity in patients with acute drug poisoning, with the aim of timely detection of pathologies of the oral mucosa in them and the appointment of complex treatment.


Assuntos
Resfriado Comum , Estomatite , Transtornos Relacionados ao Uso de Substâncias , Adulto , Feminino , Humanos , Masculino , Mucosa Bucal , Saliva
16.
Arkh Patol ; 82(3): 55-60, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32593268

RESUMO

The article is devoted to the modern perspectives of the etiology, pathogenesis, diagnosis and prognostic factors in theoral squamous cell carcinoma. In the new edition of the WHO Classification of Head and Neck Tumors of 2017, the concept of potentially malignant diseases is introduced, which include erythroplakia, leukoplakia, oral submucous fibrosis, dyskeratosiscongenita, smokeless tobacco keratosis, palatallesions associated with reverse smoking, chronic candidiasis, lichen planus, discoid lupus erythematosus, syphilitic glossitis and actinic keratosis (liponly). A binary system for assessing oral epithelial dysplasia assessing is proposed. In Chapter 5, a separation of squamous cell carcinoma with a positive and negative reaction to human papillomavirus (HPV) is performed. It has been shown that patients with HPV positive squamous cell carcinoma have a better prognosis of the disease, which confirms the clinical distinction between oropharyngeal tumors and oral mucosa.


Assuntos
Carcinoma de Células Escamosas , Neoplasias Bucais , Humanos , Leucoplasia Oral , Mucosa Bucal , Papillomaviridae , Infecções por Papillomavirus
17.
Int J Infect Dis ; 97: 326-328, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32526392

RESUMO

Some oral manifestations have been observed in patients with coronavirus disease 2019 (COVID-19). However, there is still a question about whether these lesions are due to coronavirus infection or secondary manifestations resulting from the patient's systemic condition. Thus, this article aims to report an additional case of an oral condition in a patient diagnosed with COVID-19. Our patient, a sixty-seven-year-old Caucasian man, tested positive to coronavirus and presented oral manifestations such as recurrent herpes simplex, candidiasis, and geographic tongue. We support the argument that some oral conditions could be secondary to the deterioration of systemic health or due to treatments for COVID-19. The present case report highlights the importance of including dentists in the intensive care unit multi-professional team to improve oral health in critical patients, not only COVID-19 patients, but also, to contribute to evidence-based and decision-making in managing infectious diseases.


Assuntos
Infecções por Coronavirus/patologia , Mucosa Bucal/patologia , Pneumonia Viral/patologia , Idoso , Betacoronavirus , Humanos , Masculino , Mucosa Bucal/virologia , Pandemias
18.
Georgian Med News ; (301): 68-73, 2020 Apr.
Artigo em Russo | MEDLINE | ID: mdl-32535566

RESUMO

Aim of the study- improving the methods of prevention and hygiene of the oral mucosa of dental patients receiving high-dose toxic chemotherapy. 55 patients aged from 30 to 65 years of oncological profile with a combined dental pathology were taken for clinical observation. Patients were divided into 2 groups according to the applied methods of oral hygiene: in group 1, a standard hygienic technique was used; group 2 additionally used the hygiene and prophylactic agent "CITO-STOP", adapted for patients undergoing high-dose chemotherapy. Measurement and comparison of the amount of methotrexate in the oral fluid in both groups was carried out according to a single scheme. The measurement was carried out by high performance liquid chromatography immediately before the introduction of methotrexate, then after the start of infusion at the following time intervals: 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 16 hours, 24 hours, 48 hours, respectively. The study of Candidaalbicans on sensitivity to the author's hygiene and prophylactic agent "CITO-STOP" was carried out in both groups. Means "CITO-STOP" has a declaration of conformity of the Eurasian Economic Union and is approved for clinical use and sale on the territory of the Russian Federation (Patent for invention No. 2607931 dated January 11, 2017). Statistical processing of the results was carried out in both groups according to a single technique. In samples of oral fluid in patients using the optional "CITO-STOP" for oral hygiene, the amount of methotrexate is significantly reduced. The effect of the drug on the Candidaalbicans culture leads to damage to the exocular matrix and subsequent lysis of the Candidaalbicans culture. The developed and tested author's remedy "CITO-STOP" is an effective tool for the prevention and oral hygiene of dental cancer patients. This tool has analgesic, epithelizing and antifungal properties. The amount of methotrexate in the oral fluid after the use of high-dose chemotherapy with the use of the hygienic prophylactic "CITO-STOP" has been proven to decrease. "CYTO-STOP" has a pronounced fungicidal activity Patients of the second group who used the "CITO-STOP" foam for additional oral hygiene and the prevention of post-cytostatic stomatitis noted an improvement in the quality of life by reducing the pain symptom, eliminating bleeding of the mucous membrane and halitosis (halitosis).


Assuntos
Mucosa Bucal , Higiene Bucal , Adulto , Idoso , Humanos , Higiene , Pessoa de Meia-Idade , Qualidade de Vida , Federação Russa
20.
J Med Microbiol ; 69(6): 824-829, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32478655

RESUMO

Introduction. Candida auris is an emerging fungal pathogen. The organism can cause invasive infections associated with high mortality, has been implicated in outbreaks in healthcare settings and is frequently resistant to multiple antifungal agents, making it a significant challenge to infection prevention and patient treatment.Aim. To implement a real-time PCR assay for detection of C. auris in patient surveillance samples collected with the Copan Liquid Amies elution swab (ESwab) collection and transport system.Methodology. We optimized a real-time PCR testing procedure based on the sample collection device used in our institution.Results . ESwab transport medium was strongly inhibitory to the real-time PCR. Removing the medium with centrifugation, followed by suspending the pellet in PBS-BSA buffer (concentration 1 %), sufficiently eliminated the inhibition. The manual sample preparation method, freeze-thaw followed by mechanical disruption, allowed the detection of C. auris at the lowest cell concentration.Conclusion . The optimized procedure was used to test 1414 patient surveillance samples. The real-time PCR detected all culture-positive samples with 100 % sensitivity and 100 % specificity.


Assuntos
Axila/microbiologia , Candida/isolamento & purificação , Virilha/microbiologia , Mucosa Bucal/microbiologia , Reação em Cadeia da Polimerase em Tempo Real/métodos , Candida/genética , Humanos , Sensibilidade e Especificidade
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