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1.
World Neurosurg ; 137: 239-242, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32035213

RESUMO

BACKGROUND: Rosai-Dorfman disease (RDD) is a rare idiopathic benign proliferative disorder of histiocytes, predominantly affecting the lymph nodes. RDD can also present in extranodal tissues and is occasionally found within the central nervous system. CASE DESCRIPTION: We report the case of a 52-year-old man presenting with a short episode of dizziness. Imaging identified a right frontal, extraaxial, dural-based lesion, suspicious for a meningioma. The patient underwent a craniotomy for tumor resection and, although not entirely typical, the pathology was consistent with RDD. No other evidence of RDD was identified. CONCLUSIONS: RDD should be considered as a differential diagnosis of dural-based lesions, more commonly meningiomas.


Assuntos
Neoplasias Encefálicas/patologia , Histiocitose Sinusal/patologia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/cirurgia , Craniotomia , Diagnóstico Diferencial , Tontura/etiologia , Histiócitos/patologia , Histiocitose Sinusal/diagnóstico por imagem , Histiocitose Sinusal/cirurgia , Humanos , Linfonodos/patologia , Masculino , Meningioma/diagnóstico , Meningioma/diagnóstico por imagem , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos , Resultado do Tratamento
2.
Acta Cytol ; 64(4): 386-389, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31962314

RESUMO

INTRODUCTION: Kikuchi-Fujimoto disease (KFD) may have an autoimmune etiology and some cases have been associated with silicone breast implants. Cytomorphologic features of the disease have been well characterized by fine-needle aspiration of lymph nodes. They are so specific as to permit a precise cytologic diagnosis. Cytologic features have not been reported in fluid specimens. CASE: A 33-year-old female presented with a unilateral periprosthetic silicone breast seroma. The fluid was drained, and cytological analysis revealed numerous lymphocytes with no neutrophils, karyorrhectic nuclear debris, and peculiar histiocytes with eccentrically located nuclei showing a crescentic shape. Many of those histiocytes showed intracellular apoptotic debris. CONCLUSION: A Kikuchi disease-like inflammatory reaction is possible not only in axillary and cervical lymph nodes of patients with silicone breast implants but also in breast seromas. There is still not enough evidence to establish if there is an association between KFD and breast implants. A detailed cytologic examination of periprosthetic silicone breast seromas may help answer this question. In any case, pathologists must be aware of this possibility. Cytologic features are characteristic enough to permit differentiation from breast implant-associated anaplastic large-cell lymphoma.


Assuntos
Implantes de Mama/efeitos adversos , Linfadenite Histiocítica Necrosante/etiologia , Inflamação/etiologia , Silicones/efeitos adversos , Adulto , Axila/patologia , Biópsia por Agulha Fina/métodos , Citodiagnóstico/métodos , Feminino , Histiócitos/patologia , Linfadenite Histiocítica Necrosante/patologia , Humanos , Inflamação/patologia , Linfonodos/patologia , Seroma/patologia
3.
Clin Nucl Med ; 45(3): e174-e175, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31876835

RESUMO

T-cell/histiocyte-rich B-cell lymphoma accounts for approximately 1% to 3% of all cases of diffuse large B-cell lymphoma, and involvement of the kidneys comprises a mere 1% of the total primary extranodal lymphomas. We present a case of T-cell/histiocyte-rich B-cell lymphoma who had acute renal failure at initial presentation with bilateral lymphomatous infiltration depicted on FDG PET/CT scan. Four months after the treatment, a repeat FDG PET/CT scan revealed complete resolution of the renal lesions, indicative of the complete remission for kidneys.


Assuntos
Lesão Renal Aguda/diagnóstico por imagem , Linfoma Difuso de Grandes Células B/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Lesão Renal Aguda/etiologia , Adulto , Fluordesoxiglucose F18 , Histiócitos/patologia , Humanos , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/patologia , Masculino , Compostos Radiofarmacêuticos , Linfócitos T/patologia
4.
Diagn Cytopathol ; 48(1): 66-70, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31432610

RESUMO

Juvenile xanthogranuloma (JXG) is a rare type of non-Langerhan cell histiocytic disorder, which is mostly confined to skin of head and neck. It is a self-limiting benign condition, which does not require surgery. We present a case of 8-month-old girl child with multiple yellowish brown colored papules over scalp, face, and neck. A clinical diagnosis of cutaneous mastocytosis was made. Fine-needle aspiration cytology (FNAC) smears showed foamy macrophages along with mixed inflammatory infiltrate and few touton giant cells. A diagnosis of JXG was rendered which was confirmed on histopathology and immunohistochemistry.Juvenile xanthogranuloma can be diagnosed on FNAC based on its characteristic cytologic features; however, it requires a high index of suspicion by cytopathologist. Cytological diagnosis of JXG can save the patient from unnecessary surgical biopsy or excision.


Assuntos
Pele/patologia , Xantogranuloma Juvenil/diagnóstico , Xantogranuloma Juvenil/patologia , Biópsia por Agulha Fina , Feminino , Histiócitos/patologia , Humanos , Lactente , Pele/citologia
5.
J Neuropathol Exp Neurol ; 79(1): 102-112, 2020 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-31803918

RESUMO

Myopathies during chronic graft-versus-host disease (cGvHD) are syndromes for which tissue targets and mechanisms of muscle damage remain incompletely defined. This study reviewed, and pathologically analyzed, 14 cGvHD myopathies, comparing myopathology to other immune myopathies. Clinical features in cGvHD myopathy included symmetric, proximal weakness, associated skin, gastrointestinal and lung disorders, a high serum aldolase (77%), and a 38% 2-year survival. Muscle showed noninflammatory pathology involving all 3 tissue components. Perimysial connective tissue had damaged structure and histiocytic cells. Vessel pathology included capillary loss, and reduced α-l-fucosyl and chondroitin sulfate moieties on endothelial cells. Muscle fibers often had surface pathology. Posttranslational glycosylation moieties on α-dystroglycan had reduced staining and abnormal distribution in 86%. Chondroitin-SO4 was reduced in 50%, a subgroup with 3-fold longer times from transplant to myopathy, and more distal weakness. cGvHD myopathies have noninflammatory pathology involving all 3 tissue components in muscle, connective tissue, small vessels, and myofibers. Abnormal cell surface glycosylation moieties are common in cGvHD myopathies, distinguishing them from other immune myopathies. This is the first report of molecular classes that may be immune targets in cGvHD. Disordered cell surface glycosylation moieties could produce disease-related tissue and cell damage, and be biomarkers for cGvHD features and activity.


Assuntos
Defeitos Congênitos da Glicosilação/patologia , Doença Enxerto-Hospedeiro/patologia , Inflamação/patologia , Doenças Musculares/patologia , Adulto , Idoso , Biomarcadores/metabolismo , Capilares/patologia , Tecido Conjuntivo/patologia , Feminino , Doença Enxerto-Hospedeiro/complicações , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Histiócitos/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Debilidade Muscular/patologia , Músculo Esquelético/patologia , Análise de Sobrevida
6.
Tuberk Toraks ; 67(3): 225-230, 2019 Sep.
Artigo em Turco | MEDLINE | ID: mdl-31709955

RESUMO

Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis of unknown etiology, it is characterized by organ infiltration of foamy histiocytes. Diagnosis of ECD involves the analysis of histiocytes in tissue biopsies: these are typically CD68+ CD1a-. These characteristic histiocytes may be found in almost any tissue in cases of ECD. We present an interesting case of ECD that was presented by spontaneous pneumothorax and neurological involvement.


Assuntos
Doença de Erdheim-Chester/diagnóstico por imagem , Doença de Erdheim-Chester/patologia , Pneumotórax/diagnóstico por imagem , Pneumotórax/patologia , Biópsia , Doença de Erdheim-Chester/complicações , Histiócitos , Humanos , Pneumotórax/complicações , Doenças Raras
7.
BMJ Case Rep ; 12(11)2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31678921

RESUMO

Diffuse plane xanthomatosis is a normolipemic non-Langerhan cell histiocytosis. Clinically, patient presents as asymptomatic yellowish plaques involving eyelids, neck, upper trunk and flexures. Usually, there is an associated haematological or lymphoproliferative malignancy which may precede or follow dermatological manifestations by many years. Rarely inflammatory dermatosis like atopic eczema, photosensitive dermatosis, erythroderma, previous scars and lymphoedema have been found to be associated with these xanthomas. We are reporting a 46-year-old male patient who had a history of photosensitivity for the last 15 years and subsequently developed diffuse plane normolipemic xanthomas.


Assuntos
Dermatite Fototóxica/diagnóstico , Xantomatose/etiologia , Histiócitos/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Xantomatose/patologia
8.
Arch Pathol Lab Med ; 143(12): 1497-1503, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31765251

RESUMO

CONTEXT.­: Cellular spindled histiocytic pseudotumor (CSHPT) is an exuberant, dense histiocytic proliferation seen in the setting of mammary fat necrosis. CSHPT has a broad histologic differential diagnosis, including benign, malignant, and inflammatory etiologies. OBJECTIVES.­: To highlight the most important histologic and immunohistochemical findings of CSHPT and provide comparisons to entities within the broad differential diagnosis. DATA SOURCES.­: Recently published literature regarding CSHPT and other diagnostic considerations. CONCLUSIONS.­: CSHPT is a benign histiocytic proliferation with a broad differential diagnosis, for which comprehensive ancillary studies may be required to exclude malignant and infectious entities.


Assuntos
Doenças Mamárias/diagnóstico , Doenças Mamárias/patologia , Neoplasias da Mama/diagnóstico , Necrose Gordurosa/patologia , Histiócitos/patologia , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Humanos
9.
Ann Clin Lab Sci ; 49(5): 666-670, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31611212

RESUMO

Crystal Storing Histiocytosis (CSH) is a rare entity occurring in association with underlying lymphoproliferative disorders and plasma cell neoplasms. It denotes accumulation of immunoglobulin crystals in the histiocyte cytoplasm. In this study, we report a patient with plasma cell myeloma who presented with bilateral comminuted femur fractures. Histological examination of fracture tissue revealed hypercellular (~100%) marrow with extensive involvement by sheets of histiocytes with abundant eosinophilic cytoplasm admixed with scattered plasma cells. Intracytoplasmic diamond and rhomboid crystals within histiocytes were demonstrated by electron microscopy. Immunohistochemistry highlighted monotypic plasma cells with kappa restriction, representing 20-30% of marrow cellularity; however, non-polarizable cytoplasmic striations in histiocytes were negative for light chain expression. A diagnosis of crystal-storing histiocytosis associated with plasma cell myeloma was rendered. Further evaluation of these macrophages is positive for CD163 and COX2 and shows pSTAT3 with variable nuclear staining in some histiocytes. This case demonstrates that numerous M2 macrophages are present as crystal storing histiocytosis; and this knowledge might convey prognostic and therapeutic significance for the patients with crystal storing histiocytosis.


Assuntos
Histiocitose/patologia , Macrófagos/patologia , Mieloma Múltiplo/patologia , Plasmócitos/patologia , Idoso , Cristalização , Histiócitos/patologia , Histiócitos/ultraestrutura , Humanos , Masculino , Fenótipo
11.
PLoS One ; 14(9): e0222400, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31527903

RESUMO

Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activated BRAF is sufficient for the development of LCH, we engineered mice to express BRAF V600E under the control of the human Langerin promoter. These mice have shortened survivals, smaller lymphoid organs, absent Leydig cells, and fewer epidermal LCs than controls, but do not accumulate histiocytes. To test whether the absence of histiocyte proliferation could be due to oncogene-induced senescence, we engineered homozygous Pten loss in the same cells that expressed BRAF V600E. Like mice with intact Pten, these mice have shortened survivals, smaller thymi, and absent Leydig cells. However, loss of Pten also leads to the accumulation of CD207+ histiocytes in spleen, thymus, and some lymph nodes. While many CD207+ histiocytes in the thymus are CD8-, reminiscent of LCH cells, the CD207+ histiocytes in the spleen and lymph nodes are CD8+. These mice also accumulate large numbers of CD207- cells in the lamina propria (LP) of the small intestine. Both the lymphoid and LP phenotypes are likely due to human Langerin promoter-driven BRAF V600E expression in resident CD8+ dendritic cells in the former and LP dendritic cells in the latter and confirm that Pten loss is required to overcome inhibitory pathways induced by BRAF V600E expression. The complex phenotype of these mice is a consequence of the multiple murine cell types in which the human Langerin promoter is active.


Assuntos
Histiócitos/patologia , Histiocitose de Células de Langerhans/genética , Histiocitose de Células de Langerhans/patologia , PTEN Fosfo-Hidrolase/genética , Proteínas Proto-Oncogênicas B-raf/genética , Deleção de Sequência/genética , Animais , Antígenos de Superfície/genética , Linfócitos T CD8-Positivos/patologia , Proliferação de Células/genética , Células Dendríticas/patologia , Humanos , Intestino Delgado/patologia , Masculino , Camundongos , Fenótipo , Regiões Promotoras Genéticas/genética
12.
Ann Diagn Pathol ; 43: 151403, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31494491

RESUMO

Crystal-storing histiocytosis (CSH) is a rare manifestation of monoclonal gammopathy in which histiocytes containing monoclonal proteins in their cytoplasm are found in various organs of the body including the kidney. Within the kidney, these monoclonal crystal-laden histiocytes have been described to occur in the interstitium (most commonly) or in the glomerular mesangium. CSH within glomerular capillary loops has rarely been reported. We describe three cases of CSH primarily affecting the glomerular capillaries and review the literature of CSH in general. Twenty cases of CSH involving the kidney are present in the literature; three describe CSH in glomeruli, only one of which showed histiocytes predominantly in glomerular capillary loops, while 15 had predominantly or solely interstitial CSH. Most cases involve IgG kappa crystals with only one case involving lambda light chain. Patients with CSH predominantly involving the glomerular capillaries showed a trend toward lower serum creatinine and proteinuria at presentation, and several patients with CSH lacked a definitive diagnosis of a monoclonal gammopathy at the time of diagnosis, emphasizing the role that kidney biopsy and particularly electron microscopy play in diagnosis of this entity.


Assuntos
Mesângio Glomerular/patologia , Histiocitose/complicações , Rim/patologia , Adulto , Idoso , Biópsia , Creatinina/sangue , Feminino , Mesângio Glomerular/irrigação sanguínea , Mesângio Glomerular/metabolismo , Mesângio Glomerular/ultraestrutura , Glomerulonefrite Membranosa/metabolismo , Glomerulonefrite Membranosa/patologia , Histiócitos/metabolismo , Histiócitos/patologia , Humanos , Rim/metabolismo , Rim/ultraestrutura , Transtornos Linfoproliferativos/complicações , Transtornos Linfoproliferativos/metabolismo , Transtornos Linfoproliferativos/patologia , Masculino , Microscopia Eletrônica/métodos , Pessoa de Meia-Idade , Mieloma Múltiplo/complicações , Mieloma Múltiplo/metabolismo , Mieloma Múltiplo/patologia , Síndromes Mielodisplásicas/complicações , Síndromes Mielodisplásicas/metabolismo , Síndromes Mielodisplásicas/patologia , Proteínas do Mieloma/metabolismo , Paraproteinemias/patologia , Proteinúria/diagnóstico
13.
Am J Surg Pathol ; 43(12): 1644-1652, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31414989

RESUMO

Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferation that occurs in nodal and extranodal sites. Rare examples of the disease involving the digestive system have been described. To characterize the digestive tract manifestations of this disease, 12 specimens from 11 patients with extranodal RDD affecting the digestive organs were analyzed. Hematoxylin and eosin sections and available immunohistochemical stains were reviewed, and the clinical information was obtained from patients' electronic or submitted records. Eight patients were female and 3 male (median age, 65 y; range, 17 to 76 y). Abdominal pain was the most frequent symptom. Six patients had an associated immunologic or malignant disease. Nine lesions arose in the gastrointestinal tract (1 involving the appendix, 2 right colon, 6 left colon), 2 in the pancreas, and 1 in the liver. Two patients had the coexistent nodal disease, and 1 had bone and soft-tissue involvement. The lesions were generally composed of polygonal to spindle-shaped histiocytes with eosinophilic to clear cytoplasm admixed with lymphoplasmacytic cells. The inflammatory cells formed lymphoid aggregates in 7 cases and included focally scattered or small collections of neutrophils in 6 cases. Fibrosis was variable, and 4 cases had a storiform pattern. Vasculopathy in the form of a thickened capillary wall, medium-sized arterial wall infiltration by lesional and inflammatory cells and phlebitis was seen in 10, 5, and 2 cases, respectively. All cases were reactive for S100-protein. Of the 5 patients with follow-up, 1 developed immunoglobulin A nephropathy and died of renal failure.


Assuntos
Proliferação de Células , Doenças do Sistema Digestório/patologia , Sistema Digestório/irrigação sanguínea , Sistema Digestório/patologia , Histiócitos/patologia , Histiocitose Sinusal/patologia , Doenças Vasculares/patologia , Adolescente , Idoso , Bases de Dados Factuais , Diagnóstico Diferencial , Sistema Digestório/química , Doenças do Sistema Digestório/metabolismo , Feminino , Fibrose , Histiócitos/química , Histiocitose Sinusal/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Proteínas S100/análise , Doenças Vasculares/metabolismo
14.
PLoS One ; 14(8): e0221056, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31469844

RESUMO

OBJECTIVE: Aseptic loosening (AL) is the most frequent long-term reason for revision of total knee arthroplasty (TKA) affecting about 15-20% patients within 20 years after the surgery. Although there is a solid body of evidence about the crucial role of inflammation in the AL pathogenesis, scared information on inflammation signature and its time-axis in tissues around TKA exists. DESIGN: The inflammation protein signatures in pseudosynovial tissues collected at revision surgery from patients with AL (AL, n = 12) and those with no clinical/radiographic signs of AL (non-AL, n = 9) were investigated by Proximity Extension Assay (PEA)-Immunoassay and immunohistochemistry. RESULTS: AL tissues had elevated levels of TNF-family members sTNFR2, TNFSF14, sFasL, sBAFF, cytokines/chemokines IL8, CCL2, IL1RA/IL36, sIL6R, and growth factors sAREG, CSF1, comparing to non-AL. High interindividual variability in protein levels was evident particularly in non-AL. Levels of sTNFR2, sBAFF, IL8, sIL6R, and MPO discriminated between AL and non-AL and were associated with the time from index surgery, suggesting the cumulative character of inflammatory osteolytic response to prosthetic byproducts. The source of elevated inflammatory molecules was macrophages and multinucleated osteoclast-like cells in AL and histiocytes and osteoclast-like cells in non-AL tissues, respectively. All proteins were present in higher levels in osteoclast-like cells than in macrophages. CONCLUSIONS: Our study revealed a differential inflammation signature between AL and non-AL stages of TKA. It also highlighted the unique patient's response to TKA in non-AL stages. Further confirmation of our preliminary results on a larger cohort is needed. Analysis of the time-axis of processes ongoing around TKA implantation may help to understand the mechanisms driving periprosthetic bone resorption needed for diagnostic/preventative strategies.


Assuntos
Artroplastia do Joelho/efeitos adversos , Reabsorção Óssea/fisiopatologia , Citocinas/metabolismo , Inflamação/metabolismo , Falha de Prótese/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Reabsorção Óssea/complicações , Reabsorção Óssea/metabolismo , Reabsorção Óssea/cirurgia , Feminino , Histiócitos/metabolismo , Histiócitos/patologia , Humanos , Inflamação/complicações , Inflamação/fisiopatologia , Inflamação/cirurgia , Macrófagos/metabolismo , Macrófagos/patologia , Masculino , Pessoa de Meia-Idade , Osteoclastos/metabolismo , Osteoclastos/patologia , Reoperação
15.
J Cutan Pathol ; 46(12): 945-948, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31278769

RESUMO

Histiocytoses are a group of rare disorders characterized by a proliferation of monocytes/macrophages and dendritic cells. We present a case of a 3-year-old girl with a diffuse papular eruption without systemic symptoms demonstrating a proliferation of strongly CD1a+ histiocytes, but negative for S-100 and langerin on histopathology. Systemic work-up including bone marrow biopsy was unremarkable, and the patient received a diagnosis of CD1a+ S- 100-indeterminate cell histiocytosis.


Assuntos
Antígenos CD1/metabolismo , Histiocitose/metabolismo , Histiocitose/patologia , Pré-Escolar , Feminino , Histiócitos/metabolismo , Histiócitos/patologia , Histiocitose/diagnóstico , Humanos , Imuno-Histoquímica , Pele/patologia , Dermatopatias/imunologia , Dermatopatias/patologia
18.
J Comp Pathol ; 169: 1-4, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31159945

RESUMO

An 11-month-old female Japanese macaque (Macaca fuscata), born in captivity in a research institute, suddenly died without clinical signs. Necropsy examination revealed a nodular mass protruding from the left ventral aspect of the larynx, compressing the epiglottis anteriorly. Histopathologically, the laryngeal mass was comprised of medium- to large-sized atypical cells. Immunohistochemically, these were positive for CD20 and partially positive for CD79α. Among the atypical cells were CD3+ T cells and CD68+ histiocytes. Based on the findings, this case was diagnosed as T-cell/histiocyte-rich large B-cell lymphoma. Epstein-Barr virus (EBV)-encoded small RNAs were frequently detected in the atypical cells by in-situ hybridization, which was consistent with the finding that the macaque was seropositive for EBV antigen. This is the first report showing the potential association of simian lymphocryptovirus, the simian homologue of EBV, with lymphoma in a juvenile non-human primate.


Assuntos
Infecções por Herpesviridae/veterinária , Linfoma Difuso de Grandes Células B/veterinária , Doenças dos Primatas/patologia , Doenças dos Primatas/virologia , Infecções Tumorais por Vírus/veterinária , Animais , Feminino , Histiócitos/patologia , Lymphocryptovirus , Macaca fuscata , Linfócitos T/patologia
19.
Dermatol Ther ; 32(5): e13005, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31228316

RESUMO

Rosai-Dorfman disease (RDD) is a rare disease which characterized by proliferation and overproduction of histiocytes in the lymph nodes appearing as lymphadenopathy, however, it may also occur in extranodal sites. The occurrence of unusual manifestations of the disease such as the appearance of the mass in an unusual area may increase the probability of misdiagnosis. Herein, we describe a case of RDD in an old woman with an unusual appearance of RDD in the leg that was successfully treated by thalidomide.


Assuntos
Histiócitos/patologia , Histiocitose Sinusal/tratamento farmacológico , Pele/patologia , Talidomida/administração & dosagem , Biópsia , Diagnóstico Diferencial , Relação Dose-Resposta a Droga , Feminino , Histiocitose Sinusal/diagnóstico , Humanos , Imunossupressores/administração & dosagem , Perna (Membro) , Linfonodos/patologia , Pessoa de Meia-Idade , Resultado do Tratamento
20.
Am J Dermatopathol ; 41(7): 522-525, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31233405

RESUMO

Intralymphatic histiocytosis is a rare dermatologic disorder, commonly associated with inflammatory disorders and rarely malignancy. Carcinoma erysipeloides (CE) is a rare pseudoinflammatory cutaneous eruption that resembles soft -tissue infections as result of intralymphatic metastasis and subsequent lymphatic obstruction. Breast carcinoma represents most of the CE cases, but rarely other malignancies are involved. This report discusses a patient with a history of cutaneous squamous cell carcinoma (SCC) of the temple, who was initially diagnosed with intralymphatic histiocytosis located on his upper extremity, resistant to treatment. Further dermatologic and pathologic review later revealed metastatic SCC restricted to the dermal lymphatics, creating a CE reaction, initially obscured by intralymphatic histiocytes. This case highlights the difficulty in diagnosing metastatic carcinoma when the malignant cells are accompanied by a dense histiocytic infiltrate. The case demonstrates a rare presentation of CE due to metastatic cutaneous SCC and highlights the need for persistent investigation when confronted with nonconforming pathology.


Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias Parotídeas/patologia , Neoplasias Cutâneas/patologia , Idoso , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/secundário , Carcinoma de Células Escamosas/terapia , Erros de Diagnóstico , Evolução Fatal , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/terapia , Histiócitos/patologia , Histiocitose/diagnóstico , Humanos , Metástase Linfática , Vasos Linfáticos/patologia , Masculino , Invasividade Neoplásica , Recidiva Local de Neoplasia/radioterapia , Neoplasias Parotídeas/secundário , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/secundário
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