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1.
J Med Life ; 13(1): 87-93, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32341707

RESUMO

Nurses may be anxious due to critical and emergencies, and anxiety can affect their professional performance. Non-pharmacological interventions, as a safe method, can reduce anxiety. This study aimed to determine the effect of music therapy and aromatherapy with chamomile - lavender essential oil on the anxiety of clinical nurses. This was a randomized, double-blind clinical trial. One hundred twenty nurses from clinical wards of Besat Hospital in Sanandaj, Iran, were selected between 2018 and 2019 by purposeful sampling. The samples were randomly assigned to three groups with different interventions, namely music therapy, both aromatherapy with chamomile-lavender essential oil and music therapy, and aromatherapy with chamomile-lavender essential oil, along with a control group as well. The anxiety of nurses was measured based on the Beck Anxiety Inventory before the intervention and after three work shifts. The data were analyzed using the SPSS v.22 software. One-way ANOVA was used to test the hypotheses. The findings showed that the mean scores of the anxiety of nurses after the intervention in the three groups namely the group for which music therapy was applied, the group for which aromatherapy with chamomile-lavender essential oil was used and the group for which both music therapy and aromatherapy with chamomile-lavender essential oil were applied, were (39.28), (37.82) and (40.03), respectively. Therefore, the obtained mean score of each group was significantly lower than that of the control group (56.08) (p < 0.0001). The results showed that the interventions of music therapy and aromatherapy with chamomile-lavender essential oil could reduce the anxiety of nurses. Therefore, it is recommended to use music therapy and aromatherapy with chamomile-lavender essential oil to reduce the anxiety of nurses in the clinical setting.


Assuntos
Ansiedade/terapia , Aromaterapia , Camomila/química , Lavandula/química , Musicoterapia , Enfermeiras e Enfermeiros , Óleos Voláteis/uso terapêutico , Adulto , Estudos de Casos e Controles , Método Duplo-Cego , Feminino , Humanos , Irã (Geográfico) , Masculino , Óleos Vegetais/uso terapêutico
2.
Asian Pac J Cancer Prev ; 21(3): 771-775, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-32212806

RESUMO

INTRODUCTION: Bone marrow biopsy is a common procedure for the diagnosis and treatment of hematologic diseases and tumors, which are associated with anxiety. The purpose of this study was to examine the effect of lavender aroma on anxiety of patients having bone marrow biopsy. MATERIALS AND METHODS: This study was performed on 80 patients referred to Vali-e-Asr Hospital for bone marrow biopsy. Samples were selected by convenience method and were assigned into intervention and control groups using randomized blocks of 4. Random sequence was generated by RAS software. Several drops of distilled water on a cotton ball was used in the control group and same amount of lavender essential oil on a cotton ball was used in the intervention group. Then, participants in both groups were asked to smell the cotton ball for 15 minutes and then, their anxiety level was measured immediately. The results were analyzed by SPSS software version 25 using covariance analysis and rank regression. RESULTS: The results showed that, the mean scores of anxiety in the control and intervention groups were 6.3 ± 1.92 and 3.75 ± 1.05, respectively. There was a significant difference (p <0.05) between the two groups in terms of anxiety score.The results showed that there was a significant difference in anxiety score between two groups in terms of variables such as age, gender, physician experience, biopsy history and biopsy site (P <0.05). The results also showed no significant difference between the (p >0.05). CONCLUSION: The results of this study showed that bone marrow biopsy is associated with anxiety, and smelling of lavender aroma is effective in reducing anxiety in patients undergoing this procedure. This fragrance can be used by treatment team in hematology and oncology clinics to reduce anxiety caused by bone marrow biopsy.
.


Assuntos
Ansiedade/prevenção & controle , Biópsia , Medula Óssea , Lavandula/química , Óleos Voláteis/uso terapêutico , Óleos Vegetais/uso terapêutico , Adulto , Ansiedade/etiologia , Aromaterapia , Biópsia/efeitos adversos , Medula Óssea/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Odorantes
3.
Plant Mol Biol ; 102(4-5): 517-535, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31927660

RESUMO

KEY MESSAGE: We reported the functional characterization of cDNAs encoding short-chain isoprenyl diphosphate synthases that control the partitioning of precursors for lavender terpenoids. Lavender essential oil is composed of regular and irregular monoterpenes, which are derived from linear precursors geranyl diphosphate (GPP) and lavandulyl diphosphate (LPP), respectively. Although this plant strongly expresses genes responsible for the biosynthesis of both monoterpene classes, it is unclear why regular monoterpenes dominate the oil. Here, we cloned and characterized Lavandula x intermedia cDNAs encoding geranyl diphosphate synthase (LiGPPS), geranylgeranyl diphosphate synthase (LiGGPPS) and farnesyl diphosphate synthase (LiFPPS). LiGPPS was heteromeric protein, consisting of a large subunit (LiGPPS.LSU) and a small subunit for which two different cDNAs (LiGPPS.SSU1 and LiGPPS.SSU2) were detected. Neither recombinant LiGPPS subunits was active by itself. However, when co-expressed in E. coli LiGPPS.LSU and LiGPPS.SSU1 formed an active heteromeric GPPS, while LiGPPS.LSU and LiGPPS.SSU2 did not form an active protein. Recombinant LiGGPPS, LiFPPS and LPP synthase (LPPS) proteins were active individually. Further, LiGPPS.SSU1 modified the activity of LiGGPPS (to produce GPP) in bacterial cells co-expressing both proteins. Given this, and previous evidence indicating that GPPS.SSU can modify the activity of GGPPS to GPPS in vitro and in plants, we hypothesized that LiGPPS.SSU1 modifies the activity of L. x intermedia LPP synthase (LiLPPS), thus accounting for the relatively low abundance of LPP-derived irregular monoterpenes in this plant. However, LiGPPS.SSU1 did not affect the activity of LiLPPS. These results, coupled to the observation that LiLPPS transcripts are more abundant than those of GPPS subunits in L. x intermedia flowers, suggest that regulatory mechanisms other than transcriptional control of LPPS regulate precursor partitioning in lavender flowers.


Assuntos
Alquil e Aril Transferases/metabolismo , Dimetilaliltranstransferase/metabolismo , Flores/enzimologia , Lavandula/enzimologia , Proteínas de Plantas/metabolismo , Alquil e Aril Transferases/genética , Catálise , Dimetilaliltranstransferase/genética , Difosfatos , Diterpenos , Escherichia coli/genética , Escherichia coli/metabolismo , Cromatografia Gasosa-Espectrometria de Massas , Regulação Enzimológica da Expressão Gênica , Regulação da Expressão Gênica de Plantas , Teste de Complementação Genética , Lavandula/genética , Monoterpenos/metabolismo , Fases de Leitura Aberta , Fenótipo , Filogenia , Proteínas de Plantas/genética , Plantas Geneticamente Modificadas , Terpenos/metabolismo , Tabaco/metabolismo
4.
Planta ; 251(2): 41, 2020 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-31907678

RESUMO

MAIN CONCLUSION: Using RNA-Seq, we identified genes involved in floral development in lavenders and functionally characterized the floral repressor LaSVP. The molecular aspects of flower initiation and development have not been adequately investigated in lavender (Lavandula). In order to identify genes that control these processes, we employed RNA-Seq to obtain sequence information for transcripts originating from the vegetative shoot apical meristem (SAM) and developing inflorescence tissues of Lavandula angustifolia and Lavandula × intermedia plants, and assemble a comprehensive transcriptome of 105,294 contigs. Homology-based annotation provided gene ontology terms for the majority of transcripts, including over 100 genes homologous to those that control flower initiation and organ identity in Arabidopsis thaliana. Expression analysis revealed that most of these genes are differentially expressed during flower development. For example, LaSVP, a homolog of the floral repressor SHORT VEGETATIVE PHASE (SVP), was strongly expressed in vegetative SAM compared to developing flowers, implicating its potential involvement in flowering repression in lavender. To investigate LaSVP further, we constitutively expressed the gene in transformed A. thaliana plants, evaluating its effects on flower initiation and morphology. Expression of the LaSVP in A. thaliana delayed flowering and affected flower organ identity in a dosage-dependent manner. Two of the highest expressing lines produced sepals instead of petals and were sterile as they failed to develop proper seed pods. This study provides the foundation for future investigations aimed at elucidating flower initiation and development in lavender.


Assuntos
Flores/metabolismo , Lavandula/metabolismo , Proteínas de Plantas/metabolismo , Arabidopsis/genética , Arabidopsis/metabolismo , Proteínas de Arabidopsis/genética , Proteínas de Arabidopsis/metabolismo , Flores/genética , Regulação da Expressão Gênica no Desenvolvimento , Regulação da Expressão Gênica de Plantas/genética , Regulação da Expressão Gênica de Plantas/fisiologia , Lavandula/genética , Meristema/genética , Meristema/metabolismo , Proteínas de Plantas/genética , Plantas Geneticamente Modificadas/genética , Plantas Geneticamente Modificadas/metabolismo
5.
Chem Biodivers ; 17(1): e1900496, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31909551

RESUMO

The genus Lavandula is known for its different uses in traditional medicine. This study is interested in the chemical composition of Lavandulapedunculata subsp.atlantica (Braun-Blanq.) Romo as well as evaluating its antibacterial potential against multi-resistant strains. The analysis of Lavandulaatlantica essential oil (LAEO) allows the identification of 47 components representing 93.6 % of all identified. The main constituent of LAEO was camphor (50.4 %), followed by fenchone (14.1 %) and camphene (5.6 %). The antibacterial assays revealed that LAEO was active against all the studied bacteria. A preliminary study of the relationship between certain terpenoids and antibacterial activity was also carried out in order to note the compound(s) that are responsible for LAEO's antibacterial activity. This study showed that the activity of the essential oil may be due to the presence of certain minor compounds such as carvone, considering the presence of the synergistic effect between the essential oil.


Assuntos
Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos , Lavandula/química , Óleos Voláteis/farmacologia , Terpenos/farmacologia , Antibacterianos/análise , Relação Dose-Resposta a Droga , Testes de Sensibilidade Microbiana , Óleos Voláteis/análise , Relação Estrutura-Atividade , Terpenos/análise
6.
Braz J Biol ; 80(1): 87-96, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31017237

RESUMO

Asthma is an inflammatory disease of the lungs, and it causes oxidative stress. Lavandula dentata is an aromatic herb with anti-oxidative and anti-inflammatory activities. This study examined the activity of L. dentata extract on a guinea pig model of asthma. Adult males were divided into five groups: First group was control, second was asthma model induced by OVA, third was treated with L. dentata extract orally (300 mg/kg) for 21 days; the fourth was an asthma model with L. dentata extract (300 mg/kg) and fifth was treated with Tween 80 for 21 days. OVA treatment increased IgE, triglycerides, total cholesterol, glucose levels in serum, WBC count in blood and MDA in lungs. Also, OVA reduced SOD activity, GSH content in lungs, and GGT activity in serum (p<0.05). L. dentata extract treatment in asthma model reduced elevated IgE, triglycerides, total cholesterol, glucose levels in serum, and MDA in lungs (p<0.05), while it increased GSH content in lungs (p<0.05). These results suggest the possibility that L . dentata extract can exert suppressive effects on asthma, and may provide evidence that it is a useful agent for the treatment of allergic airway disease, it also limits oxidative stress induced by OVA. L. dentata extract appears to have hypolipidemic and hypoglycemic activities.


Assuntos
Asma , Lavandula , Animais , Líquido da Lavagem Broncoalveolar , Modelos Animais de Doenças , Cobaias , Masculino , Ovalbumina , Extratos Vegetais
7.
J Chromatogr A ; 1610: 460568, 2020 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-31586515

RESUMO

Polarimetric HPLC detector was used to acquire chromatograms for lavender/lavandin essentials oils (EOs) on different chiral stationary phases. Amylose tris-(3,5-dichloro-phenylcarbamate) immobilized on silica allowed the best separation of the numerous chiral phytomarkers and was thus used to obtain a chiroptical fingerprint for 158 samples of French lavender/lavandin EOs. Samples from different varieties (Abrial, Fine, Grosso, Maillette, Matherone, Sumian and Super) were collected over three crop years (2012, 2013 and 2014), from four different locations in France (``Alpes-de-Haute-Provence'', ``Ardèche'', ``Drôme'' and ``Vaucluse'') to take into account seasonal and geographic origin variations. The combination of the polarimetric fingerprints and chemometrics was tested for varietal discrimination. We assessed the ability to discriminate the EOs samples and their variety by partial least squares-discriminant analysis (PLS-DA). This case study showed that liquid chromatography with polarimetric detector in tandem with chemometric analysis was efficient to differentiate the varietal origins of French lavender/lavandin EOs.


Assuntos
Lavandula/química , Óleos Vegetais/análise , Cromatografia Líquida de Alta Pressão , Análise Discriminante , França , Análise dos Mínimos Quadrados , Óleos Voláteis/química , Óleos Vegetais/química , Análise de Componente Principal , Estereoisomerismo
8.
BMC Complement Altern Med ; 19(1): 306, 2019 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-31711477

RESUMO

BACKGROUNDS: The chemical composition of many essential oils indicates that they have sedative and hypnotic effects, but there is still a lack of systematic studies on the sedative and hypnotic effects of essential oils. In addition, aromatherapy does not seem to have the side effects of many traditional psychotropic substances, which is clearly worthwhile for further clinical and scientific research. The clinical application of essential oils in aromatherapy has received increasing attention, and detailed studies on the pharmacological activities of inhaled essential oils are increasingly needed. HYPOTHESIS/PURPOSE: As insomniacs are usually accompanied by symptoms of depression and anxiety of varying degrees, based on the theory of aromatherapy of Traditional Chinese Medicine, this experiment is to study a Compound Anshen essential oil that is compatible with Lavender essential oil, Sweet Orange essential oil, Sandalwood essential oil and other aromatic medicine essential oils with sedative and hypnotic effects, anti-anxiety and anti-depression effects. To study the sedative and hypnotic effects of Compound Anshen essential oil inhaled and the main chemical components of Compound Anshen essential oil, and to compare and analyze the pharmacodynamics of diazepam, a commonly used drug for insomnia. METHODS: The Open field test and Pentobarbital-induced sleep latency and sleep time experiments were used to analyze and compare the sedative and hypnotic effects of inhaling Compound Anshen essential oil and the administration of diazepam on mice. The changes of 5-HT and GABA in mouse brain were analyzed by Elisa. The main volatile constituents of Compound Anshen essential oil were analyzed by gas chromatography-mass spectrometry (GC-MS). RESULTS: Inhalation of Compound Anshen essential oil can significantly reduce the spontaneous activity of mice, reduce latency of sleeping time and prolong duration of sleeping time. The results of enzyme-linked immunosorbent assay showed that Compound Anshen essential oil can increase the content of 5-HT and GABA in mouse brain. The main volatile chemical constituents of the Compound Anshen essential oil are D-limonene (24.07%), Linalool (21.98%), Linalyl acetate (15.37%), α-Pinene (5.39%), and α-Santalol (4.8%). CONCLUSION: The study found that the inhalation of Compound Anshen essential oil has sedative and hypnotic effect. This study provides a theoretical basis for further research and development of the sedative and hypnotic effects of Compound Anshen essential oil based on the theory of aromatherapy.


Assuntos
Aromaterapia , Hipnóticos e Sedativos/administração & dosagem , Óleos Voláteis/administração & dosagem , Óleos Vegetais/administração & dosagem , Distúrbios do Início e da Manutenção do Sono/terapia , Administração por Inalação , Animais , Encéfalo/metabolismo , Citrus sinensis/química , Feminino , Humanos , Lavandula/química , Masculino , Camundongos , Camundongos Endogâmicos ICR , Óleos Voláteis/química , Óleos Vegetais/química , Santalum/química , Serotonina/metabolismo , Sono , Distúrbios do Início e da Manutenção do Sono/metabolismo , Distúrbios do Início e da Manutenção do Sono/fisiopatologia , Ácido gama-Aminobutírico/metabolismo
9.
Asian Nurs Res (Korean Soc Nurs Sci) ; 13(5): 295-305, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31743795

RESUMO

PURPOSE: Although lavender is purported to possess anxiolytic and sedative properties and is often recommended for relieving anxiety, the efficacy of lavender has not been well established. Thus, this review aimed to evaluate the anxiolytic effects of lavender aromatherapy. METHODS: Ten data bases were searched for studies published between 2000 and 2018. Randomized controlled trials investigating the anxiolytic effects of lavender aromatherapy with any type of application for persons with or without clinical anxiety were included. The outcome variables included self-rated anxiety, vital signs, and salivary cortisol and chromogranin A (CgA) levels. In the meta-analysis, standardized mean difference and 95% confidence interval were calculated as effect measures by applying the random effect model and inverse variance method. RESULTS: Twenty-two trials met our inclusion criteria. Lavender aromatherapy was found to have favorable effects in relieving anxiety (Hedges' g = -0.65; 95% CI, -0.84 to -0.46) and decreasing systolic blood pressure (g = -0.22; 95% CI, -0.43 to -0.02), heart rate (g = -0.53; 95% CI, -0.74 to -0.32), and salivary cortisol (g = -1.29; 95% CI, -2.23 to -0.35) and CgA (g = -2.29; 95% CI, -3.24 to -1.34) levels. However, the meta-analysis did not reveal any significant effects of lavender on diastolic blood pressure (effect size: -0.17; 95% CI, -0.37-0.04). CONCLUSION: Aromatherapy using lavender oil might have favorable effects on anxiety and its physiological manifestations. Future studies are recommended with an emphasis on methodological quality. In nursing practice, it is suggested that lavender aromatherapy be included in programs intended to manage anxiety in patients across diverse healthcare settings.


Assuntos
Ansiolíticos/uso terapêutico , Transtornos de Ansiedade/terapia , Aromaterapia/métodos , Lavandula , Óleos Voláteis/uso terapêutico , Óleos Vegetais/uso terapêutico , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
10.
Planta ; 251(1): 5, 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31776766

RESUMO

MAIN CONCLUSION: We cloned eight transcription factors that activate lavender monoterpene synthase promoters. In this study, we employed the Yeast One-Hybrid (Y1H) assay system to identify transcription factors that control promoters for two Lavandula × intermedia monoterpene synthase genes, linalool synthase (LiLINS) and 1,8-cineole synthase (LiCINS). The bait sequences used in the assay were either a 768-bp LiLINS, or a 1087-bp LiCINS promoter. The prey included proteins expressed in L. × intermedia floral tissue. The assay identified 96 sequences encoding proteins that interacted with one or both promoters. To explore the nature of this interaction, the LiLINS and LiCINS promoter fragments were each fused to the E. coli gusA (GUS) reporter gene. The constructs were separately transformed into tobacco (Nicotiana benthamiana) leaves co-expressing individually a subset of ten representative transcription factors (TFs) predicted to control these promoters. Six TFs induced expression from both promoters, two activated LiCINS promoter alone, and two did not induce expression from either promoter. The TFs identified in this study belong to various groups including those containing conserved domains typical of MYB, bZIP, NAC, GeBP and SBP-related proteins.


Assuntos
Lavandula/metabolismo , Fatores de Transcrição/metabolismo , Escherichia coli/genética , Escherichia coli/metabolismo , Regulação da Expressão Gênica de Plantas/genética , Regulação da Expressão Gênica de Plantas/fisiologia , Lavandula/enzimologia , Lavandula/genética , Regiões Promotoras Genéticas/genética , Tabaco/genética , Tabaco/metabolismo , Fatores de Transcrição/genética
11.
Complement Ther Med ; 47: 102208, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31780012

RESUMO

OBJECTIVE: Physiologically, blood melatonin levels decrease as a person ages and the older adult commonly presents with insomnia and other types of sleep disorders. Alternative therapies can be used to attenuate sleep disturbances. The aim of the present study was to analyze the effect of aromatherapy with lavender on serum melatonin levels in the noninstitutionalized older adult (OA). DESIGN AND SETTING: A pre-experimental, quantitative study with a pre-test - post-test design was conducted on 67 OAs that included both sexes. MAIN OUTCOME MEASURES: Serum melatonin levels were measured before and after eight sessions of aromatherapy with lavender that lasted 4 weeks. The results were expressed as mean ±â€¯standard deviation of melatonin levels (pg/ml). The differences were compared using the Student's t-test and statistical significance was set at a p ≤ 0.05. RESULTS: Blood melatonin levels significantly increased in the total population after the intervention with aromatherapy (pg/ml): 102.3 ±â€¯33.4 VS 132.5 ±â€¯42.3, p = 0.000004. There were significant differences in the pre-test and post-test phases in the women and men measured as separate groups (p = 0.00005 and p = 0.026), respectively. However, those differences were not observed when the measurements were compared between the two sexes, before (p = 0.64) or after (p = 0.31) the intervention. CONCLUSION: Aromatherapy with lavender essential oil similarly favors an increase in blood melatonin levels in both older adult men and women.


Assuntos
Aromaterapia/métodos , Lavandula , Melatonina/sangue , Óleos Voláteis/uso terapêutico , Óleos Vegetais/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
12.
Asian Pac J Cancer Prev ; 20(10): 2943-2949, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31653139

RESUMO

BACKGROUND: Breast cancer is the most common cause of deaths in women. The search for traditionally used medicinal plants which can serve as non-toxic and affordable anticancer drugs is the need of the hour. This study aimed to investigate the anticancer potential of extracts of L. coronopifolia against human breast carcinoma cell line (MDA-MB-321). METHODS: The MDA-MB-231 cells were plated in 96 well plates and exposed to 10-1,000 µg/ml of L. coronopifolia for 24 h. The cytotoxic response of different extracts was measured by MTT assay, neutral red uptake (NRU) assay and cellular morphological alterations under the microscope. RESULTS: A concentration-dependent decrease in the cell viability of MDA-MB-231 cells was observed after the exposure of petroleum ether, ethyl acetate, chloroform, and ethanol extracts of L. coronopifolia. The cell viability was found to be 82%, 89% and 98% at 1000, 500 and 250 µg/ml, respectively in petroleum ether, 37%, 75% and 88% at 1,000, 500 and 250 µg/ml, respectively in ethyl acetate extract, 30%, 35% and 64% at 1,000, 500 and 250 µg/ml, respectively in chloroform extract and 44%, 65% and 82% at 1000, 500 and 250 µg/ml, respectively in ethanolic extract of L. coronopifolia exposed MDA-MB-231 cells. The results also exhibited morphological alterations in MDA-MB-231 cells exposed to various extracts. The cells treated with 250- 1000 µg/ml lost their original morphology and cell linkage as compared to control cells. CONCLUSION: These preliminary results suggest the promising anticancer potential of petroleum ether, ethyl acetate, chloroform, and ethanol extracts of L. coronopifolia against MDA-MB-321 cells. Further studies are required to know the mechanism(s) involved in the cell death.


Assuntos
Acetatos/química , Alcanos/química , Neoplasias da Mama/patologia , Proliferação de Células/efeitos dos fármacos , Clorofórmio/química , Etanol/química , Lavandula/química , Extratos Vegetais/farmacologia , Antineoplásicos Fitogênicos/farmacologia , Neoplasias da Mama/tratamento farmacológico , Feminino , Humanos , Células Tumorais Cultivadas
13.
Phytomedicine ; 65: 153099, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31655395

RESUMO

BACKGROUND: Anxiety is one of the uprising psychiatric disorders of the last decades and lavender administration has been traditionally suggested as a possible treatment. The objective of this review is to assess the efficacy of lavender, in any form and way of administration, on anxiety and anxiety-related conditions. METHODS: The PRISMA guidelines were followed. Retrieved data were qualitatively and quantitatively synthesized. Randomized Controlled Trials (RCTs) and Non-Randomized Studies (NRSs) which investigated the efficacy of lavender, in any form and way of administration, on patients with anxiety, involved in anxiety-inducing settings or undergoing anxiety-inducing activities, compared to any type of control, without language restrictions, were identified through electronic database searches. Medline via PubMed, Scopus, Web of Science, Cochrane Library, EMBASE, and Google Scholar were systematically searched. All databases were screened up to November 2018. Risk of bias was assessed with the Cochrane risk-of-bias tool and the following domains were considered: randomization, allocation sequence concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases. RESULTS: 65 RCTs (7993 participants) and 25 NRSs (1200 participants) were included in the qualitative synthesis and 37 RCTs (3964 participants) were included in the quantitative synthesis. Overall, the qualitative synthesis indicated that 54 RCTs and 17 NRSs reported at least a significant result in favor of lavender use for anxiety. The quantitative synthesis showed that lavender inhalation can significantly reduce anxiety levels measured with any validated scale (Hedges' g = -0.73 [95% CI -1.00 to -0.46], p < 0.00001, 1682 participants), as well as state anxiety (Spielberger's state-trait anxiety inventory (STAI)-State mean difference = -5.99 [95% CI -9.39 to -2.59], p < 0.001, 901 participants) and trait anxiety (STAI-Trait mean difference = -8.14 [95% CI -14.44 to -1.84], p < 0.05, 196 participants). Lavender inhalation did not show a significant effect in reducing systolic blood pressure as a physiological parameter of anxiety. A significant effect in diminishing anxiety levels was also found in favor of the use of oral Silexan® 80 mg/die for at least 6 weeks (Hamilton Anxiety Scale mean difference = -2.90 [95% CI -4.86 to -0.95], p = 0.004, 1173 participants; Zung Self-rating Anxiety Scale mean difference = -2.62 [95% CI -4.84 to -0.39], p < 0.05, 451 participants) or of the administration of massage with lavender oil (Hedges' g = -0.66 [95% CI -0.97 to -0.35], p < 0.0001, 448 participants). DISCUSSION: The most important limitation of this review is the low average quality of available studies on the topic. The majority of included RCTs were characterized by a high overall risk of bias. Another limitation regards the heterogeneity of study designs, especially with regard to non-oral ways of administration. Overall, oral administration of lavender essential oil proves to be effective in the treatment of anxiety, whereas for inhalation there is only an indication of an effect of reasonable size, due to the heterogeneity of available studies. Lavender essential oil administered through massage appears effective, but available studies are not sufficient to determine whether the benefit is due to a specific effect of lavender. Further high-quality RCTs with more homogeneous study designs are needed to confirm these findings. Available information outlines a safe profile for lavender-based interventions, although more attention should be paid to the collection and reporting of safety data in future studies. Considering these findings, since treatments with lavender essential oil generally seem safe, and, in the case of inhalation, also simple and inexpensive, they are a therapeutic option which may be considered in some clinical contexts. OTHER: The present systematic review was not funded and was registered in PROSPERO under the following number: CRD42019130126.


Assuntos
Transtornos de Ansiedade/tratamento farmacológico , Lavandula/química , Óleos Voláteis/farmacologia , Óleos Vegetais/farmacologia , Administração por Inalação , Administração Oral , Ansiedade/tratamento farmacológico , Pressão Sanguínea/efeitos dos fármacos , Humanos , Óleos Voláteis/administração & dosagem , Óleos Vegetais/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como Assunto
14.
Molecules ; 24(18)2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31540149

RESUMO

Due to their numerous health benefits associated with various diseases and anti-oxidation properties, the phenolic compounds collectively referred to as phytochemicals have attracted a lot of interest, however, a single extraction method for polyphenols has not been developed yet. Supercritical fluid extraction, a green extraction method, provides the final product without organic solvent residues. In this work the extraction of lavender was performed using supercritical carbon dioxide. A statistical experimental design based on the Box-Behnken (B-B) method was planned, and the extraction yields and total phenolic contents were measured for three different variables: pressure, temperature and extraction time. The ranges were 200-300 bar, 40-60 °C and 15-45 min. The extracts yields from scCO2 extraction were in the range of 4.3-9.2 wt.%. The highest yield (9.2 wt.%) was achieved at a temperature of 60 °C under the pressure of 250 bar after 45 min. It also corresponded to the highest total phenolic content (10.17 mg GAE/g extract). Based on the study, the statistically generated optimal extraction conditions to obtain the highest total phenolic compounds concentration from flowers of Lavandula angustifolia were a temperature of 54.5 °C, pressure of 297.9 bar, and the time of 45 min. Based on the scavenging activity percentage (AA%) of scCO2 extracts, it is concluded that the increase of extraction pressure had a positive influence on the increase of AA% values.


Assuntos
Cromatografia com Fluido Supercrítico/métodos , Flores/química , Lavandula/química , Polifenóis/isolamento & purificação , Dióxido de Carbono/química , Manufaturas/economia , Fenóis/análise , Fenóis/isolamento & purificação , Extratos Vegetais/química , Polifenóis/análise , Pressão , Projetos de Pesquisa , Solventes/química , Temperatura , Tempo
15.
Molecules ; 24(18)2019 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-31500359

RESUMO

Lavender oil is one of the most valuable aromatherapy oils, its anti-bacterial and anti-fungal activities can be explained by main components such as linalool, linalyl acetate, lavandulol, geraniol, or eucalyptol. The aim of the study was to assess the anti-microbial effects of two different lavender oils on a mixed microbiota from facial skin. The commercial lavender oil and essential lavender oil from the Crimean Peninsula, whose chemical composition and activity are yet to be published, were used. Both oils were analysed by gas chromatography coupled to mass spectrometry. The composition and properties of studied oils were significantly different. The commercial ETJA lavender oil contained 10% more linalool and linalyl acetate than the Crimean lavender oil. Both oils also had different effects on the mixed facial skin microbiota. The Gram-positive bacilli were more sensitive to ETJA lavender oil, and Gram-negative bacilli were more sensitive to Crimean lavender oil. However, neither of the tested oils inhibited the growth of Gram-positive cocci. The tested lavender oils decreased the cell number of the mixed microbiota from facial skin, but ETJA oil showed higher efficiency, probably because it contains higher concentrations of monoterpenoids and monoterpenes than Crimean lavender oil does.


Assuntos
Antibacterianos/farmacologia , Monoterpenos/farmacologia , Óleos Voláteis/farmacologia , Óleos Vegetais/farmacologia , Pele/microbiologia , Monoterpenos Acíclicos/análise , Antibacterianos/química , Face , Cromatografia Gasosa-Espectrometria de Massas , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Humanos , Lavandula/química , Testes de Sensibilidade Microbiana , Monoterpenos/análise , Monoterpenos/química , Óleos Voláteis/química , Óleos Vegetais/química
16.
Eur J Oncol Nurs ; 42: 90-96, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31476706

RESUMO

PURPOSE: To examine the effects of the addition of lavender essential oil to the colostomy bag of the patients with permanent colostomy on the elimination of odor, quality of life, and ostomy adjustment. METHODS: As a parallel group, single-blinded randomized controlled trial with repeated measures, this study was conducted between November 2016 and February 2018. Patients with a permanent colostomy that had opened at least three months before the study were stratified according to age and sex and were randomized according to days of week. The study sample included 15 patients in the experimental group and 15 in the control group. Patients in the experimental group used lavender essential oil in the ostomy bag, and patients in the control group continued their routine practices about nutrition and stoma care for 1 month. RESULTS: There were no statistically significant differences in demographic characteristics between the experimental and control groups (p > 0.05). As compared with the control group patients, the experimental group patients who used lavender essential oil in the ostomy bag experienced statistically significant less odor, a higher quality of life, and better adjustment to ostomy (all p < 0.05). CONCLUSIONS: The use of lavender essential oil in the ostomy bag is a simple, low-cost, easy-to-use, and natural method that is effective for increasing both ostomy adjustment and quality of life levels and for eliminating odor in permanent colostomy patients.


Assuntos
Neoplasias Colorretais/terapia , Colostomia/psicologia , Ajustamento Emocional , Lavandula , Óleos Voláteis/uso terapêutico , Qualidade de Vida , Adulto , Idoso , Neoplasias Colorretais/psicologia , Colostomia/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Odorantes
17.
Molecules ; 24(16)2019 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-31405026

RESUMO

True lavender flowers (Lavandula angustifolia Mill.) is a critical source of essential oils and a flavouring agent used in numerous industries like foods, cosmetics and pharmaceuticals. Its main volatile constituents are linalool and linalyl acetate, which are commonly considered as main odour-active constituents (OACs). Nevertheless, the quality of true lavender flowers is highly dependent on its post-harvest treatment, mainly the preservation method. Recognising that drying is the most frequently used preservation method, the influence of various drying methods, including convective drying (CD) at 50, 60 and 70 °C, vacuum-microwave drying (VMD) with powers 240, 360 and 480 W and combined convective pre-drying at 60 °C followed by vacuum-microwave finish-drying with power 480 W (CPD-VMFD), on the quality of true lavender flowers was verified. The evaluation of influence was carried out by HS-SPME(HS, solid-phase microextraction), GC-MS, GC-MS-O (gas chromatography-mass spectrometry-olfactometry) techniques. Moreover, the sensory panel has assessed the sample odour quality. As a result, the optimal drying methods regarding the requirements for products were established. Overall, for total essential oil recovery, CD at 50 °C is the optimal drying method, while for odour quality concerning the sensory panel evaluation, VMD with power 360 W combined CPD-VMFD and CD at 50 °C is the optimal drying method.


Assuntos
Aromatizantes , Flores/química , Lavandula/química , Óleos Voláteis , Dessecação , Aromatizantes/análise , Aromatizantes/química , Aromatizantes/isolamento & purificação , Micro-Ondas , Óleos Voláteis/análise , Óleos Voláteis/química , Óleos Voláteis/isolamento & purificação , Extração em Fase Sólida
18.
Chem Biodivers ; 16(10): e1900371, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31464066

RESUMO

The essential oils of five Lavandula stoechas cultivars grown in Thailand were characterized for their volatile compounds using GC-FID and GC/MS methods as well as screened for antibacterial and antioxidant activities. Dried aerial parts, including flowers and stems from each cultivar, were subjected to hydrodistillation for 4 h. The essential oil yields were 0.18 %-0.82 % w/w. Of the 95 compounds detected and identified, 1,8-cineole, fenchone, and camphor were considered the major compounds. Essential oil from each cultivar demonstrated different patterns of antibacterial activity and a variety of antioxidant properties. The highest antibacterial activity, MIC=0.39 mg mL-1 , was observed from the essential oil of L. stoechas 'major' (against Klebsiella pneumoniae and Salmonella typhimurium) and the essential oil of L. stoechas 'white lavender' (against S. typhimurium). The essential oil of L. stoechas×viridis 'St. Brelade' possessed the highest antioxidant capacity, as determined by the DPPH and ABTS assays (IC50 of 67.65 and 89.26 mg mL-1 , respectively). The results indicated that some of these essential oils could be used as key ingredients in lavender oil products in Thailand to increase their therapeutic efficacy, depending on their intended application.


Assuntos
Antibacterianos/farmacologia , Antioxidantes/farmacologia , Klebsiella pneumoniae/efeitos dos fármacos , Lavandula/química , Óleos Voláteis/farmacologia , Salmonella typhimurium/efeitos dos fármacos , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antioxidantes/química , Antioxidantes/isolamento & purificação , Benzotiazóis/antagonistas & inibidores , Compostos de Bifenilo/antagonistas & inibidores , Flores/química , Lavandula/crescimento & desenvolvimento , Testes de Sensibilidade Microbiana , Óleos Voláteis/química , Óleos Voláteis/isolamento & purificação , Picratos/antagonistas & inibidores , Componentes Aéreos da Planta/química , Ácidos Sulfônicos/antagonistas & inibidores , Tailândia
19.
Molecules ; 24(15)2019 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-31387317

RESUMO

BACKGROUND: essential oils are well known for their pharmacological effectiveness as well as their repellent, insecticide, and herbicide activities. The emergence of resistant weeds, due to the overuse of synthetic herbicides, makes it necessary to find natural alternatives for weed control. The aim of this study was to evaluate the phytotoxic effects of Eucalyptus citriodora, Lavandula angustifolia, and Pinus sylvestris, three common commercial essential oils, on weeds (Portulaca oleracea, Lolium multiflorum, and Echinochloa crus-galli), food crops (tomato and cucumber), and the invasive species Nicotiana glauca. Methods: to determine herbicidal effects, essential oils were tested at different concentrations (0.125-1µL/mL). The index of germination and seedling length data were recorded over 14 days. RESULTS: the in vitro assays showed that L. angustifolia with linalool (38.7 ± 0.1%), 1,8-cineole (26.5 ± 0.1%), and camphor (14.2 ± 0.1%) as the main compounds showed the most phytotoxic effects affecting seed germination in weeds and tomato, and the aforementioned invasive species. L. multiflorum was the most sensitive weed, particularly to lavender essential oil, which decreased the growth of its hypocotyl and radicle by 87.8% and 76.7%, respectively, at a dose of 1 µL/mL. Cucumber was the most resistant food crop, with no significant reduction observed in seed germination and hypocotyl growth with E. citriodora and L. angustifolia essential oils. CONCLUSIONS: lavender essential oil represents a promising candidate for the development of effective and safe herbicides in the management of L. multiflorum affecting cucumber crops.


Assuntos
Eucalyptus/química , Lavandula/química , Óleos Voláteis/farmacologia , Pinus sylvestris/química , Produtos Agrícolas/efeitos dos fármacos , Cromatografia Gasosa-Espectrometria de Massas , Germinação/efeitos dos fármacos , Herbicidas/farmacologia , Espécies Introduzidas , Óleos Voláteis/química , Plantas Daninhas/efeitos dos fármacos , Plântula/efeitos dos fármacos , Controle de Plantas Daninhas
20.
Molecules ; 24(15)2019 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-31349556

RESUMO

Essential oils from Lavandula genus and the obtained hybrids are widely used for different purposes such as perfume production in the cosmetic field and for its biological properties. This is the first study on the liquid and vapour phase of Lavandula × intermedia "Grosso" essential oil grown in the Lazio Region, Italy, investigated using headspace coupled to gas chromatography and mass spectrometry (HS-GC/MS). The results showed the most abundant components were linalool and linalyl acetate, followed by 1,8-cineole and terpinen-4-ol, while lavandulyl acetate and borneol were identified as minor compounds, maintaining the same proportion in both the liquid and vapour phase. Furthermore, we tested lavandin liquid and vapour phase essential oil on gram-negative bacteria (Escherichia coli, Acinetobacter bohemicus, and Pseudomonas fluorescens) and gram-positive bacteria (Bacillus cereus and Kocuria marina).


Assuntos
Lavandula/química , Óleos Voláteis/química , Óleos Voláteis/farmacologia , Transição de Fase , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Cromatografia Gasosa-Espectrometria de Massas , Testes de Sensibilidade Microbiana , Compostos Fitoquímicos/química , Compostos Fitoquímicos/farmacologia
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