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J Med Food ; 21(8): 823-831, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29565700


Tropaeolum majus L., popularly known as nasturtium, is a species widely used in the form of infusions and salads. In the last years, the antihypertensive, diuretic, and calcium and potassium sparing activities of T. majus preparations were shown. Moreover, no preclinical 90-day oral toxicity studies were conducted. Thus, this study evaluated the toxicity of the hydroethanolic extract obtained from T. majus (HETM) leaves in female and male mice, rats, and rabbits. Swiss mice and Wistar rats were treated with HETM (75, 375, and 750 mg/kg). The doses of rabbits (30, 150, and 300 mg/kg) were calculated by allometric extrapolation. The control groups received vehicle. The animals were orally treated, daily, for 90 days. At the end, the animals were anesthetized, and body weight gain, relative weight of liver, kidney, and spleen, and histopathological changes were evaluated. Serum hematological and biochemical parameters were also analyzed. No alterations were found in body and organ weights or in histopathological and biochemical evaluation. Hematological analyses revealed small changes in lymphocytes and neutrophil counts in rats after administration of 750 mg/kg of HETM. These results showed that 90-day use of T. majus is safe in rodents and lagomorphs.

Extratos Vegetais/toxicidade , Folhas de Planta/toxicidade , Tropaeolaceae , Administração Oral , Animais , Relação Dose-Resposta a Droga , Feminino , Masculino , Camundongos , Fitoterapia , Coelhos , Ratos , Ratos Wistar
J Ethnopharmacol ; 141(1): 418-23, 2012 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-22433534


ETHNOPHARMACOLOGICAL RELEVANCE: Tropaeolum majus L. (Tropaeolaceae) is a medicinal herb popularly used in Brazil for treatment of inflammatory and cardiovascular diseases. Despite some published data on its efficacy, there are still few toxicological data describing the safety of this plant. The aim of this study was to evaluate the (anti)estrogenic and (anti)androgenic activity of the hydroethanolic extract obtained from Tropaeolum majus L. (HETM), as well as its possible effects on uterine contractility. MATERIALS AND METHODS: Three experimental protocols were performed, (a) uterotrophic assay, (b) Hershberger assay and (c) an ex vivo test to investigate the effects of maternal administration of HETM on uterine contractility at the end of pregnancy. In all protocols three doses of the HETM were administered to Wistar rats: 3, 30 and 300mg/kg. RESULTS: In vivo tests for detection of (anti)androgenic and (anti)estrogenic activities did not show any significant alterations. Similarly, no alterations were observed on uterine contractility induced by oxytocin and arachidonic acid. CONCLUSIONS: HETM was unable to produce (anti)estrogenic or (anti)androgenic activities in the short-term in vivo screening assays performed. In addition, there was no evidence that HETM can affect uterine contractility following gestational exposure of rats.

Antagonistas de Androgênios/farmacologia , Androgênios/farmacologia , Moduladores de Receptor Estrogênico/farmacologia , Estrogênios/farmacologia , Extratos Vegetais/farmacologia , Tropaeolaceae , Contração Uterina/efeitos dos fármacos , Antagonistas de Androgênios/administração & dosagem , Antagonistas de Androgênios/isolamento & purificação , Androgênios/administração & dosagem , Androgênios/isolamento & purificação , Animais , Moduladores de Receptor Estrogênico/administração & dosagem , Moduladores de Receptor Estrogênico/isolamento & purificação , Estrogênios/administração & dosagem , Estrogênios/isolamento & purificação , Etanol/química , Feminino , Idade Gestacional , Masculino , Exposição Materna , Orquiectomia , Ocitócicos/farmacologia , Pênis/efeitos dos fármacos , Pênis/crescimento & desenvolvimento , Fitoterapia , Extratos Vegetais/administração & dosagem , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Gravidez , Próstata/efeitos dos fármacos , Próstata/crescimento & desenvolvimento , Ratos , Ratos Wistar , Glândulas Seminais/efeitos dos fármacos , Glândulas Seminais/crescimento & desenvolvimento , Solventes , Tropaeolaceae/química , Útero/efeitos dos fármacos , Útero/crescimento & desenvolvimento