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1.
An Bras Dermatol ; 95(2): 214-216, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32151408

RESUMO

Papillary intralymphatic angioendothelioma (Dabska tumor) is a rarely metastasizing lymphatic vascular neoplasm that usually affects children and young adults. The majority of these cases occur in soft tissues of extremities, and to date less than 40 cases have been described. Despite the generally indolent evolution, can be locally invasive with the potential to metastasize. We describe a case of a young woman presenting with a plantar lesion, for 9 months and histological diagnosis of Dabska tumor. This neoplasm should be considered in the differential diagnosis of vascular dermatoses, allowing early diagnosis and treatment. Long-term follow-up should be performed.


Assuntos
Doenças do Pé/patologia , Hemangioendotelioma/patologia , Tumores de Vasos Linfáticos/patologia , Adulto , Biópsia , Dermoscopia , Diagnóstico Diferencial , Feminino , Doenças do Pé/diagnóstico , Hemangioendotelioma/diagnóstico , Humanos , Tumores de Vasos Linfáticos/diagnóstico , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia
2.
HNO ; 62(1): 12-8, 2014 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-24434958

RESUMO

The therapy of vascular tumors and malformations should be interdisciplinary and performed according to available guidelines. Infantile hemangiomas (IH) are the most frequent vascular tumors of childhood and do not require treatment in most cases. If the IH is complicated by its location (e.g. facial or genital) or if the lesion threatens to cause loss of function, small localized IH should be treated by laser- or cryotherapy. If the IH is diffuse or rapidly growing it can be successfully treated using the ß blocker propranolol. The mechanism underlying the efficacy of this medication-based therapy is not completely understood and this still represents an experimental therapy. The results of molecular studies on vascular malformations have indicated new strategies for medical therapies. However, lymphatic malformations (LM) are still treated by surgery where possible, or sclerotherapy. Further investigations are necessary to determine whether new drugs such as the mTOR inhibitor rapamycin may be effective for treatment of diffuse LM. First case reports seem to be promising.


Assuntos
Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Hemangioma/tratamento farmacológico , Anormalidades Linfáticas/tratamento farmacológico , Tumores de Vasos Linfáticos/tratamento farmacológico , Propranolol/uso terapêutico , Sirolimo/uso terapêutico , Antibióticos Antineoplásicos/uso terapêutico , Feminino , Hemangioma/diagnóstico , Humanos , Lactente , Recém-Nascido , Masculino , Vasodilatadores/uso terapêutico
3.
HNO ; 62(1): 6-11, 2014 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-24343056

RESUMO

Lymphatic malformations are congenital abnormalities of the lymphatic system which occur predominantly in the head and neck region. According to their dominant clinical and morphological characteristics, these are classified into micro- and macrocystic forms. Established therapies for lymphatic malformations include conventional surgery, sclerotherapy and laser treatment. Despite the significant improvements in therapeutic options seen in recent years, treatment of extensive lymphatic malformations remains an interdisciplinary challenge. Close-knit interdisciplinary cooperation is necessary to provide optimized care for affected individuals.


Assuntos
Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/terapia , Anormalidades Linfáticas/diagnóstico , Anormalidades Linfáticas/terapia , Tumores de Vasos Linfáticos/diagnóstico , Tumores de Vasos Linfáticos/terapia , Soluções Esclerosantes/uso terapêutico , Diagnóstico por Imagem/métodos , Cabeça/diagnóstico por imagem , Cabeça/patologia , Humanos , Terapia a Laser/métodos , Pescoço/diagnóstico por imagem , Pescoço/patologia , Radiografia , Escleroterapia/métodos
5.
Urology ; 82(2): e11-2, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23896118

RESUMO

Renal lymphangiomatosis is a rare disease characterized by lymphatic vessel proliferation. We present a case of an adult patient with chronic flank pain, hypertension, and a right kidney mass. The magnetic resonance imaging findings were consistent with unilateral renal lymphangiomatosis. Technetium-99m dimercaptosuccinic acid renal scintilography revealed decreased ipsilateral renal function. From these findings, the patient underwent right nephrectomy, which resulted in complete remission of his hypertension and pain.


Assuntos
Hipertensão/etiologia , Neoplasias Renais/complicações , Neoplasias Renais/diagnóstico , Tumores de Vasos Linfáticos/complicações , Tumores de Vasos Linfáticos/diagnóstico , Adulto , Humanos , Neoplasias Renais/cirurgia , Tumores de Vasos Linfáticos/cirurgia , Imagem por Ressonância Magnética , Masculino , Nefrectomia
6.
Clin Imaging ; 37(2): 211-8, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23465970

RESUMO

OBJECTIVE: The purpose of our article is to review the magnetic resonance imaging (MRI) features of nongynaecologic cystic lesions of the pelvis. CONCLUSION: The rising use of MRI for pelvic exploration will result in an increase in incidental detection of pelvic cystic cysts. Pelvic cysts of non gynecologic origin are less frequent than gynecologic cysts. However, they account for a wide range of abnormalities, and radiologists must be aware of their features and characteristics.


Assuntos
Cistos/diagnóstico , Imagem por Ressonância Magnética/métodos , Pelve , Cordoma/diagnóstico , Meios de Contraste , Humanos , Tumores de Vasos Linfáticos/diagnóstico , Linfocele/diagnóstico , Meningocele/diagnóstico , Neoplasias Embrionárias de Células Germinativas/diagnóstico , Doenças Peritoneais/diagnóstico
7.
J Craniomaxillofac Surg ; 41(5): 437-43, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23270683

RESUMO

OBJECTIVE: To determine the epidemiology, histological diagnosis and treatment outcome of oro-facial tumours and tumour-like lesions in Greek children and adolescents. MATERIAL AND METHODS: The medical records of patients with oro-facial lesions who presented at the Department of Oral and Maxillofacial Surgery at "A. & P. Kyriakou" Children's Hospital from 2000 to 2010 were reviewed. Data was analyzed in relation to age, gender, location, histology, treatment choice and outcome. RESULTS: Two hundred and eleven oro-facial lesions were identified. Age ranged from 14 days to 15 years (mean 8 years); the male-to-female ratio was 1.09: 1; 90.05% of the lesions were benign and 9.95% malignant. Vascular anomalies were the most common benign lesion (22.1%) and rhabdomyosarcoma was the most prevalent malignancy (28.57%). One hundred and ten lesions (52.1%) involved soft tissue, most commonly the tongue and 96 cases (45.5%), involved hard tissue, most frequently the mandible; 5 lesions (2.4%) involved both hard and soft tissue. Surgery was performed under general anaesthesia in 198 cases (93.84%). Some malignant lesions were treated with chemotherapy and/or radiotherapy. CONCLUSIONS: Oro-facial tumours and tumour-like lesions are not uncommon in the Greek paediatric population; although most frequently benign, these may cause considerable morbidity. As such early diagnosis and treatment are imperative.


Assuntos
Neoplasias Faciais/epidemiologia , Neoplasias Bucais/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Seguimentos , Grécia/epidemiologia , Humanos , Lactente , Recém-Nascido , Tumores de Vasos Linfáticos/epidemiologia , Masculino , Neoplasias Mandibulares/epidemiologia , Terapia Neoadjuvante/estatística & dados numéricos , Neoplasias de Tecido Vascular/epidemiologia , Tumores Odontogênicos/epidemiologia , Procedimentos Cirúrgicos Bucais/estatística & dados numéricos , Estudos Retrospectivos , Rabdomiossarcoma/epidemiologia , Neoplasias de Tecidos Moles/epidemiologia , Neoplasias da Língua/epidemiologia , Resultado do Tratamento
8.
Lymphat Res Biol ; 9(4): 205-12, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22196287

RESUMO

Lymphatic malformations and lymphatic-derived tumors commonly involve the head and neck, where they may be associated with bony abnormalities and other systemic symptoms. The reasons for the association between these disorders and local skeletal changes are largely unknown, but such changes may cause significant disease-related morbidity. Ongoing work in molecular and developmental biology is beginning to uncover potential reasons for the bony abnormalities found in head and neck lymphatic disease; this article summarizes current knowledge on possible mechanisms underlying this association.


Assuntos
Doenças Ósseas/diagnóstico , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/metabolismo , Tumores de Vasos Linfáticos/diagnóstico , Tumores de Vasos Linfáticos/metabolismo , Doenças Ósseas/complicações , Doenças Ósseas/diagnóstico por imagem , Osso e Ossos/metabolismo , Osso e Ossos/patologia , Células Endoteliais/metabolismo , Matriz Extracelular/metabolismo , Matriz Extracelular/patologia , Neoplasias de Cabeça e Pescoço/complicações , Humanos , Tumores de Vasos Linfáticos/complicações , Radiografia , Transdução de Sinais
9.
Cancer Lett ; 305(2): 144-9, 2011 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-21172728

RESUMO

Epstein-Barr virus (EBV) a ubiquitous gamma herpesvirus persists for life, generally without health consequences. However, it is associated with several well-recognized malignancies, such as Burkitt's lymphoma and nasopharyngeal carcinoma. A growing list of malignancies has been proposed to be EBV-associated: most of which are consistently EBV-positive whereas others show inconsistent results. The possible contribution of EBV to the development and/or progression of different "non-classical" tumors is discussed in terms of putative "non-traditional'' infection in EBV-related tumors.


Assuntos
Neoplasias da Mama/virologia , Neoplasias Hepáticas/virologia , Tumores de Vasos Linfáticos/virologia , Neoplasias da Mama/complicações , Carcinoma/complicações , Carcinoma/virologia , Progressão da Doença , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/virologia , Feminino , Herpesvirus Humano 4/imunologia , Humanos , Neoplasias Hepáticas/complicações , Tumores de Vasos Linfáticos/complicações , Modelos Biológicos , Neoplasias das Glândulas Salivares/complicações , Neoplasias das Glândulas Salivares/virologia , Neoplasias Gástricas/complicações , Neoplasias Gástricas/virologia , Neoplasias do Colo do Útero/complicações , Neoplasias do Colo do Útero/virologia
13.
Clin Cancer Res ; 15(8): 2637-46, 2009 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-19351758

RESUMO

PURPOSE: Unlike carcinomas, soft-tissue sarcoma (STS) rarely exhibit lymphatic spread. Consequently, we examined expression and function of vascular endothelial growth factor (VEGF)-C and STS-associated lymphatic vessel density (LVD) components of this process. EXPERIMENTAL DESIGN: VEGF-C and VEGF-A mRNA and VEGF-C protein expression were evaluated in STS, STS cell lines, and breast cancers (reverse transcription-PCR, quantitative reverse transcription-PCR, and ELISA). STS cell conditioned medium after VEGF-C knockdown was examined for endothelial cell proliferation and migration effects (MTS and migration assays). Paraffin-embedded human lymph node-negative and lymph node-positive STS and lymph node-negative and lymph node-positive breast cancers were examined for VEGF-C, D2-40, and CD31 expression (immunohistochemistry). LVD differences were analyzed by Wilcoxon rank-sum tests. RESULTS: STS and breast cancer VEGF-C expression was comparable and higher than normal tissue levels. STS cells secreted functional VEGF-C: STS conditioned medium induced lymphatic endothelial cell proliferation and migration, which was abrogated by STS cell VEGF-C knockdown. STS and breast cancer intratumoral LVD was similar. STS peritumoral LVD (PT-LVD) was reduced versus breast cancer PT-LVD (P < 0.001). Significantly higher PT-LVD was observed in lymph node-positive versus lymph node-negative STS; lymphatic spreading STS subtypes also had higher LVD. STS VEGF-C expression and PT-LVD lacked correlation, and many lymph node-negative STS had high PT-LVD, suggesting complexity in this metastatic process. CONCLUSIONS: Compared with breast cancers, STS exhibited lower PT-LVD independent of VEGF-C expression, which may underlie STS lymph node metastasis rarity. Moreover, lymphatic vessels appear necessary but not sufficient to sustain STS lymphatic spread. Examining STS "nonlymphatic" dissemination may help elucidate mechanisms of lymphatic spread, insights critically important to cancer metastasis control.


Assuntos
Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Sarcoma/patologia , Fator C de Crescimento do Endotélio Vascular/biossíntese , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Linhagem Celular Tumoral , Movimento Celular/fisiologia , Células Endoteliais/fisiologia , Técnicas de Silenciamento de Genes , Humanos , Metástase Linfática , Tumores de Vasos Linfáticos/metabolismo , RNA Interferente Pequeno/metabolismo , Sarcoma/metabolismo , Fator C de Crescimento do Endotélio Vascular/genética
14.
Ann Urol (Paris) ; 40(4): 211-9, 2006 Aug.
Artigo em Francês | MEDLINE | ID: mdl-16970064

RESUMO

Renal carcinoma, the third most common urological cancer, induces presence of metastases in 75% of cases. The most affected sites for metastasis are the lungs, the lymphatic system, bones, the liver, adrenal glands and the brain with sometimes a cancer free period of several years prior to evolutionary recurrence of the disease. The aim of this literature review is to report on secondary uncommon renal localizations by underlining their clinical significance, as well as main characteristics, in order to provide guidelines for effective patient diagnosis and therapeutic management.


Assuntos
Carcinoma de Células Renais/secundário , Neoplasias Renais/patologia , Neoplasias das Glândulas Suprarrenais/secundário , Neoplasias Ósseas/secundário , Neoplasias Encefálicas/secundário , Carcinoma de Células Renais/diagnóstico , Carcinoma de Células Renais/terapia , Humanos , Neoplasias Renais/diagnóstico , Neoplasias Renais/terapia , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/secundário , Tumores de Vasos Linfáticos/secundário , Prognóstico
15.
Clin Pediatr (Phila) ; 45(6): 544-9, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16893860

RESUMO

In this study, the clinical and laboratory features of children with lymphadenopathy were evaluated. Over a 3-year period, 126 patients were referred to the clinic for lymphadenopathy. Twenty-eight of cases have diseases mimicking lymphadenopathy; 98 (mean age: 86+/-55 months) have lymphadenopathy. Localized, limited, and generalized involvement was found in 52%, 30%, and 18% of patients. The most common localization was the head and neck region. The causes of lymphadenopathy were benign diseases in 75 patients. Sixty percent were reactive lymphadenopathy, 39% were lymphadenitis. Lymphadenitis was more frequently localized and bigger than 3 cm compared with reactive adenopathy (p=.02, p=.004). Twenty-three patients have malignant diseases whose mean age was higher than others (p=.002). The enlargement of supraclavicular nodes was more likely due to malignant disease (p=.001). The risk of malignant disease was higher in patients who had generalized lymphadenopathy, lymph nodes bigger than 3 cm, hepatosplenomegaly, and high lactate dehydrogenase levels. In conclusion, this study pointed out the important clues for the differential diagnosis, which were present in the history, physical, and laboratory findings.


Assuntos
Doenças Linfáticas/diagnóstico , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Linfonodos/patologia , Linfadenite/patologia , Doenças Linfáticas/patologia , Tumores de Vasos Linfáticos/diagnóstico , Tumores de Vasos Linfáticos/patologia , Linfoma/diagnóstico , Linfoma/patologia , Masculino
16.
Pediatr Dev Pathol ; 8(2): 181-9, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15719202

RESUMO

The distinction between lymphatic and other vascular vessels on microscopic sections is a challenging task. D2-40, a novel antibody, has been reported to be selective for lymphatic endothelium. We studied the specificity and sensitivity of D2-40 in pediatric vascular tumors and malformations. Fourteen lymphatic and 11 vascular lesions were randomly selected and stained with D2-40 and CD31 antibodies. The lymphatic lesions included 6 lymphatic malformations, 5 cystic hygromas (macrocystic lymphatic malformation), 2 lymphovenous malformations, and 1 lymphangioma, and the vascular lesions comprised 3 infantile hemangiomas, 3 Kaposiform hemangioendotheliomas, 2 tufted angiomas, 1 pyogenic granuloma, 1 arteriovenous, and 1 venulocapillary malformations. The staining patterns of the vascular channels were compared. In all lesions D2-40 labeled only the endothelium of thin-walled vascular channels morphologically consistent with lymphatic vessels (25 of 25). No staining of the vascular lesions (0 of 11) or of arteries and veins (0 of 25) was observed. All lymphatic lesions had D2-40-positive vessels; however, the percentage of vessels that stained varied. Five lymphatic lesions showed more than 75% D2-40-positive channels, 5 lesions had approximately 50%, and 4 cases showed fewer than 25% D2-40-positive channels. There was a tendency of more consistent D2-40 staining of small versus large lymphatic channels. CD31 constantly labeled arteries, veins, capillaries, and lymphatics in all lesions and all endothelial cells in the vascular lesions. D2-40 is a very specific antibody for lymphatic endothelium, with variable sensitivity. CD31 more reliably identifies lymphatic endothelium. Currently, D2-40 appears to be a good marker to identify lymphatic vessels in pediatric vascular tumors and malformations.


Assuntos
Anticorpos Monoclonais , Endotélio Linfático/patologia , Tumores de Vasos Linfáticos/patologia , Vasos Linfáticos/anormalidades , Neoplasias de Tecidos Moles/patologia , Adolescente , Anticorpos Monoclonais/imunologia , Biomarcadores/metabolismo , Criança , Pré-Escolar , Endotélio Linfático/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Lactente , Recém-Nascido , Tumores de Vasos Linfáticos/metabolismo , Vasos Linfáticos/metabolismo , Masculino , Sensibilidade e Especificidade , Neoplasias de Tecidos Moles/metabolismo
18.
J Pediatr Health Care ; 18(1): 3-7, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-14722499

RESUMO

Cervical lymphadenopathy is a common problem in children. The condition most commonly represents a transient response to a benign local or generalized infection, but occasionally it might herald the presence of a more serious disorder. Acute bilateral cervical lymphadenopathy usually is caused by a viral upper respiratory tract infection or streptococcal pharyngitis. Acute unilateral cervical lymphadenitis is caused by streptococcal or staphylococcal infection in 40% to 80% of cases. The most common causes of subacute or chronic lymphadenitis are cat scratch disease, mycobacterial infection, and toxoplasmosis. Supraclavicular or posterior cervical lymphadenopathy carries a much higher risk for malignancies than does anterior cervical lymphadenopathy. Generalized lymphadenopathy is often caused by a viral infection, and less frequently by malignancies, collagen vascular diseases, and medications. Laboratory tests are not necessary in the majority of children with cervical lymphadenopathy. Most cases of lymphadenopathy are self-limited and require no treatment. The treatment of acute bacterial cervical lymphadenitis without a known primary source should provide adequate coverage for both Staphylococcus aureus and group A beta hemolytic streptococci.


Assuntos
Doenças Linfáticas/diagnóstico , Adolescente , Criança , Pré-Escolar , Cistos/diagnóstico , Diagnóstico Diferencial , Humanos , Lactente , Recém-Nascido , Infecções/complicações , Doenças Linfáticas/etiologia , Doenças Linfáticas/fisiopatologia , Doenças Linfáticas/terapia , Tumores de Vasos Linfáticos/complicações , Tumores de Vasos Linfáticos/diagnóstico , Pescoço
19.
Lymphat Res Biol ; 2(4): 165-72, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15650386

RESUMO

The recent surge of interest in the lymphatic system can be attributed to two factors: the discovery of cytokines that induce the growth of new lymphatic capillaries and the identification of lymphatic endothelial-specific markers. In contrast to the above, there is a paucity of techniques for studying lymphatic function in vivo. This article reviews imaging and other techniques that allow the assessment of lymphatic function, particularly in the tumor microenvironment, and proposes novel solutions for probing the same in vivo.


Assuntos
Diagnóstico por Imagem , Tumores de Vasos Linfáticos , Neoplasias , Animais , Corantes , Humanos , Imagem por Ressonância Magnética , Neoplasias/patologia
20.
Cancer Sci ; 94(6): 508-14, 2003 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12824875

RESUMO

No studies have ever precisely investigated the mechanism of nodal metastasis based on the histological characteristics of tumor cells in lymph vessels and lymph nodes. The purpose of this study was to investigate whether the histological characteristics of tumor cells in lymph vessels and lymph nodes of 393 patients with invasive ductal carcinoma (IDC) were significantly associated with increased nodal metastasis compared with well known histological characteristics of their primary-invasive tumor cells. Multivariate analyses showed that having a single nodal metastasis was closely dependent on primary-invasive tumor size or distance of lymph vessel tumor emboli from the margin of the primary-invasive tumor (P < 0.05) and that having 2 or more nodal metastases was significantly associated with the histological characteristics of the nodal metastatic tumors independently of the size of the primary-invasive tumor, and the number of nodes with extra-nodal invasion (ENI) significantly increased the relative risk (RR) of 4 or more nodal metastases in IDCs 20 to 50 mm in size, number of lymph vessels invaded, severe fibrosis of the stroma of extra-nodal invasive tumors, and distance of ENI from the node significantly increased the RR of 10 or more nodal metastases in the multivariate analysis (P < 0.05). The results of this study strongly suggest that the histological characteristics of tumor cells in lymph nodes and lymph vessels play an important role in nodal metastasis in IDCs of the breast.


Assuntos
Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/secundário , Linfonodos/patologia , Tumores de Vasos Linfáticos/secundário , Adulto , Idoso , Neoplasias da Mama/terapia , Carcinoma Ductal de Mama/terapia , Progressão da Doença , Feminino , Humanos , Japão , Metástase Linfática , Vasos Linfáticos/patologia , Menopausa , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , Prognóstico
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